Digital Commons Network^™

C-Metalated Nitriles: Diastereoselective Alkylations And Arylations, Robert John Mycka

Electronic Theses and Dissertations

Development of an sp³ hybridized halogen-magnesium exchange route to Grignard reagents, chelation-controlled asymmetric induction of γ- and δ-hydroxynitriles as well as a diastereoselective arylation procedure for C-zincated nitriles have been explored. Sequential addition of i-PrMgCl and n-BuLi to 3- and 4-carbon iodoalcohols triggers a facile halogen-metal exchange to generate cyclic magnesium alkoxides capable of intercepting electrophiles to produce a diverse range of substituted alcohols. This work advances progress toward the synthesis of highly desirable chiral Grignard reagents.

Double deprotonation of γ- and δ-acyclic hydroxynitriles with i-PrMgCl effects highly diastereoselective alkylations via a singly-chelated magnesiated nitriles. …

A Study Of Chloride Levels In Pine Creek, Allegheny County, Pa, Selina Prettner

Electronic Theses and Dissertations

Pine Creek is a 22.8-mile long tributary to the Allegheny River draining over 67 square miles of northern Allegheny County, PA. The main stem runs along Route 8 and receives extensive runoff from road salt from deicing. A site near Etna, PA sampled biweekly in 2013 consistently showed elevated conductivity that correlated with increased chloride levels. Winter road deicing runoff produced acute chloride concentrations up to 678 mg/L. Chloride fluctuated in the summer and autumn months but did not exceed the USEPA Secondary Drinking Water Standard (250 mg/L) or the aquatic life criterion for chronic concentrations (230 mg/L). Sampling throughout …

A Case Study Of An Online Teacher Study Group As A Digital Professional Development Tool, Jessica Martin

Electronic Theses and Dissertations

In recent years, there appears to have been a shift in professional development approaches for teachers from short-term workshops to teacher communities of professional practice, which extend over a while and focus on the expert knowledge teachers need to use in their setting (Goya, 2014). A supportive approach to teacher learning communities is a teacher study group. An even more promising and flexible approach to teacher learning communities in a global aspect is an online teacher study group. An online teacher study group provided a universal and flexible venue to engage in collaborative discussion between general education and special education …

Mission As Virtuous Practice: A Theology Of Mission Through The Lens Of Virtue Ethics, Michael Niebauer

Electronic Theses and Dissertations

This work uses theological virtue ethics as a guide both for critiquing various models of Christian mission and for constructing a model of mission that adequately addresses these criticisms. The first section of the dissertation (chapters one, two, and three) is devoted to an assessment of three major models of mission, which I have labeled mission as the missio Dei, mission as growth, and mission as dialogue. This assessment generates three recurring issues within the field of missiology that have remained largely unresolved: the problems of distinction, agency, and persuasion. The second half of the dissertation (chapters four, five, …

A Theological Appraisal Of Marriage In Tiv Culture, Emmanuel Ahua

Electronic Theses and Dissertations

Marriage is humanity’s essential characteristic. It is the essential union between male and female geared towards raising and sustaining rational family life in society. This is what makes people human and differentiate them from other animals. Marriage is a natural institution and a socio-cultural reality in which each group of people should determine, according to their own context. In other words, every institution, society, and culture have a right to choose what type of marriage arrangement that best explains and works for it.

Nevertheless, the Western European understanding of marriage, as adopted by the Catholic Church’s Magisterium in her teaching, …

A Darker Side Of Venus: An Empirical-Phenomenological Study Of Women's Negative Experiences Encountering Pornographic Imagery, Rebecca Gimeno

Electronic Theses and Dissertations

This empirical-phenomenological study explores the psychological dimensions of negatively encountering a pornographic image. The study includes four participants, all adult women who have had an adverse encounter with a pornographic image within the past five years at the time of the data collection. The recollected experiences of the participants were collected through written narratives as well as semi-structured interviews.

The written narratives and recorded audio interviews were transcribed and subsequently analyzed using an empirical-phenomenological analysis, a process that yielded situated structures. From this analysis, thematic elements of each structure were brought to light. Some of the thematic elements that were …

"Frontline In Mental Healthcare": A Discourse Analytic Clinical Ethnography Of Crisis Intervention Team Trainings For Corrections, Daniel Gruner

Electronic Theses and Dissertations

Throughout the criminal justice system operates a discourse of corrections-reform. This responds to prisoner trauma and resistance by converting them into reforms that strengthen prisons and the larger carceral system while discounting issues of race and class that might undermine institutional legitimacy. The recent adoption of Crisis Intervention Team (CIT) Trainings in corrections is exemplary of corrections-reform discourse. ‘Crisis’ comes from the Greek krinein, meaning ‘to decide.’ The crisis in mental health in prisons involves deciding when to implement what “services” or “programming” for whom.

In this discourse analytic clinical ethnographic study, I focus on the trans-disciplinary corrections …

Bureaucratic Modernity And The Erosion Of Practical Reason: A Rhetorical Education As An Antidote, David Impellizzeri

Electronic Theses and Dissertations

To what extent and in what ways does modernity reveal itself through the bureaucratic? This project aims at an interpretive understanding of bureaucratic modernity. The rationalization of society and action in the (late) modern world requires that an increasing number of human activities and domains be explained in allegedly neutral, ‘rational’ terms and without reference to morally substantive ends. Ultimately, this entails a form of epistemic reductionism that elevates instrumental rationality to the exclusion of practical reason and probabilistic ways of knowing. Bureaucratic modernity signifies a decrease in choices that can be legitimized in public on some basis other …

Charismatic Renewal And Pentecostalism: The Renewal Of The Nigerian Catholic Church, Isidore Nkwocha

Electronic Theses and Dissertations

This project is using Charismatic and Pentecostal theology and praxes to argue for the renewal of the Nigerian Catholic church. It avers that the praxis-oriented and experiential theology of the Charismatics and Pentecostals, which characterize them as Spirit-filled groups and churches are enabling the Nigerian Catholic church to realize the potentials of a Spirit-driven church through the renewal of her pneumatological, ecclesiological, and liturgical doctrines and practices

Nanomedicine-Driven Neuropathic Pain Relief In Rat Model Is Associated With Macrophage Polarity And Mast Cell Activation, Muzamil Saleem

Electronic Theses and Dissertations

We explored the immune neuropathology underlying multi-day relief from neuropathic pain in a rat model initiated at the sciatic nerve by using a nanoemulsion-based nanomedicine as a biological probe. The nanomedicine is theranostic: both therapeutic (containing celecoxib drug) and diagnostic (containing near-infrared fluorescent (NIRF) dye) and is small enough to be phagocytosed by circulating monocytes. A model of neuropathic pain is initiated by tying four 1mm spaced knots around the sciatic nerve with chromic gut suture, which results in neuroinflammation, and a resultant pain-like behavior manifests. We show that pain-like behavior reaches a plateau of maximum hypersensitivity 8 days post-surgery, …

Characterization Of The Effect Of Exercise Dose And Integrative Nonpharmacological Therapies In The Treatment Of Chronic Pain, Anna M. Polaski

Electronic Theses and Dissertations

Chronic pain includes debilitating conditions affecting large populations of people throughout the world. These diseases are further complicated by comorbid psychological disorders which make chronic pain conditions difficult to treat. Nonpharmacological treatment options have more recently become an important mainstay of effective therapies and are currently being used to supplement or replace traditional pharmacological treatment methods. Exercise-based therapies in particular are of interest due to their demonstrated success in reducing pain symptoms as well as improving psychological outcomes. Dose is an important factor in being able to effectively prescribe treatments in the context of specific exercise interventions and specific pain …

Natural Law, The Object Of The Act, And Double Effect: Moral Methodology For Catholic Health Care Ethics, Travis Stephens

Electronic Theses and Dissertations

Pope John Paul II’s Encyclical Veritatis Splendor is the first and only magisterial document that systematically articulates a moral methodology for Catholic moral theology. This dissertation makes explicit the methodological connection between Vatican teaching and the United States Bishops’ Ethical and Religious Directives for Catholic Health Care Services. The thesis of the dissertation explains the systematic connection between Natural Law, the Moral Object of the Act, and the Principle of Double Effect and by extension the ethical Principle of Cooperation. Second, the thesis applies this complex moral method of official teaching to health care ethics.

Following the introduction, chapter …

Females In Stem: Self-Efficacy Within Women Who Pursue Stem Majors, Lori Grata

Electronic Theses and Dissertations

While many efforts have been made within the United States, women are still underrepresented within STEM. Research within this document shows that women and men score similarly on STEM-related standardized tests. The question remains, why are there still large quantities of men outnumbering women in college majors and career fields of STEM? Looking at female STEM self-efficacy and gender role in culture could provide insight to the problem at hand. A survey was given to investigate self-efficacy and students’ STEM backgrounds of undergraduate female students who are currently in a 4-year STEM-related major within one university.

Nature Relatedness: Investigating Differences Among Rural, Suburban, And Urban Populations In Connection To Nature Scores, Elizabeth K. Skinner

Electronic Theses and Dissertations

The study examined the Nature Relatedness scores of people from rural, suburban, and urban populations to investigate differences among these populations. Survey participants also reported on whether or not they were currently raising children under the age of 18 in their home, how many outdoor activities they participated in as children and currently as adults, and their hours of screen time per day. These variables were examined to measure their impact on Nature Relatedness scores. Results showed significant differences in the Nature Relatedness scores of people from rural and urban, and urban and suburban populations. This study found that people …

Influence Of Biosolids Upon The Uptake Of Mn And Cd By Radish (Raphanus Sativus L.), Oluwadamilola O. Fateru

Electronic Theses and Dissertations

The influence of biosolids upon the uptake of Mn and Cd by radish (Raphanus sativus L.) was investigated through the characterization of biosolids, sequential extraction of the biosolids, and the determination of the metal content in the root, shoot and leaves of radish (Raphanus sativus L.).The biosolid samples from Nacogdoches Wastewater Sludge (NWWS), Lufkin Wastewater Sludge (LWWS), Soil Therapy Compost (STC) had pHs between 5.33 – 6.74. The elemental compositions of the biosolid samples were determined using inductively coupled plasma optical emission spectroscopy (ICP-OES) and SEM/EDX. Major elements (K, Mg, Mn, P) needed for plant growth …

Long-Term Study Of Prescribed Fire Effects On Stand Dynamics And Oak Regeneration Potentials In Degraded Upland Oak-Hickory Stands In Northwestern Arkansas, Mason C. Danheim, Kathryn R. Kidd Dr, Hal O. Liechty Dr, Brian P. Oswald Dr

Electronic Theses and Dissertations

Upland oak-hickory forests in the Ozark Mountains of northwestern Arkansas and south central Missouri were impacted by oak decline during the early 2000s. This decline event was caused by predisposing (e.g., mature, dense stand conditions), inciting (i.e., drought), and contributing (e.g., red oak borer, E. rufulus H., outbreak) factors. Immediately following onset of the decline, substantial crown dieback and tree mortality, particularly for two red oak species (northern red oak, Quercus rubra Michx. and black oak, Q. velutina Lam.), were observed. In addition, densities of advanced oak regeneration were inadequate at this time, resulting in poor regeneration potentials for …

Coordination Of Airway Protective Behaviors And Swallow: Effects Of Afferent Feedback And Sex., Alyssa D. Huff

Electronic Theses and Dissertations

This dissertation represents a series of studies describing mechanisms related to breathing, upper airway behaviors and their coordination in man and animal. Chapter two transformed the cough swallow aspiration protocol from the cat (previous work) to the human introducing a new strategy, volume targeting, in swallow breathing coordination. Chapter three evaluated swallow breathing coordination at increasing altitudes. As respiratory drive altered due to hypoxia and hypocapnia, swallow breathing coordination shifted toward inspiration occurring during the transition from inspiration and expiration. The collection of the two previous studies led to development of an animal model to evaluate volume targeting and …

Involuntary Memories After Stressor Exposure: Contribution Of Hormonal Status And Rumination In Women., Samantha C. Patton

Electronic Theses and Dissertations

Women experience fewer traumatic stressors over their lifespan than men, but demonstrate a higher prevalence of major depression and stressor-related disorders as a result of trauma exposure (Breslau & Anthony, 2007; Kessler et al., 2005). Differences in prevalence of stressor-related disorders may partially be due to sex-linked vulnerabilities related to emotional memory. Emotion assists in modulation of memory through neurological processes. This modulation enhances memory for emotional stimuli and can lead to a greater frequency of involuntary recall after stressor exposure. This involuntary memory is also a hallmark symptom of Posttraumatic Stress Disorder (PTSD). Sex-linked vulnerabilities, specifically hormonal status and …

Electrospun Fibers And Nanoparticles For The Prevention Of Sexually Transmitted Infections., Kevin Michael Tyo

Electronic Theses and Dissertations

Human immunodeficiency virus-1 (HIV-1) and herpes simplex virus 2 (HSV-2) affect hundreds of millions of people worldwide, with women disproportionately impacted by these infections. Currently, only oral pre-exposure prophylaxis (PrEP) is approved specifically for the prevention of HIV-1, but is challenged with adverse side effects associated with long-term use. Topical delivery platforms, such as gels and films, deliver agents directly to the female reproductive tract, but are limited in providing transient-release. The technology of polymeric electrospun fibers may serve as alternative topical delivery platform to the female reproductive tract. In these studies, we fabricated electrospun fibers comprised of different polymers …

Characterizing The Roles Of Neutral Ceramidase In Cisplatin-Induced Kidney Injury., Sophia M. Sears

Electronic Theses and Dissertations

Cisplatin is a commonly used chemotherapeutic agent with a dose-limiting nephrotoxicity. 30% of patients given cisplatin develop acute kidney injury (AKI). AKI increases risk of chronic kidney disease (CKD) development and mortality. Patients that don’t develop clinical AKI are still at risk for long term declines in renal function. Currently, there are no FDA approved agents to treat or prevent cisplatin-induced kidney injury (CDDP-KI). In this study, we demonstrated that neutral ceramidase (nCDase) knockout provides protection from AKI in the high-dose model of CDDP-KI. However, in the repeated low dose cisplatin (RLDC) model of injury and we found nCDase knockout …

Reaching Zero Waste: Determining The Student Perspective On Campus Food Waste., Cassie Anne Parkins

Electronic Theses and Dissertations

Food waste is an ongoing problem in the complex global food system. College campuses are in a unique position to address food waste through reducing it in their own food systems and by encouraging students to develop behaviors to reduce and divert waste from landfills. In this thesis project I seek to understand how students consider food waste and their attitudes and ideas about reducing it. To this end, I observed student behaviors and waste in University of Louisville’s all-you-care-to-eat dining hall and weighed plate waste there. I conducted informational interviews with University and Aramark employees, along with semi-structured interviews …

Charting A Course Through Confusion: Mapping Pathological Cranial Lesions In An Archaic Population From Kentucky., Austin Warren

Electronic Theses and Dissertations

Osteological observations interpreted as evidence for anemia (porotic hyperostosis and cribra orbitalia) have been used to interpret health and diet of past populations. These observations have contributed significantly to arguments that a deterioration of human health over time can be attributed to the adoption of agricultural subsistence practices and increased settlement aggregation. This study utilized a sample (n=110) from the Ward site (15Mcl11), a pre-agricultural, fisher-hunter-gatherer cemetery site dated to the Archaic Period in Kentucky, a part of the Shell Midden Archaic cultural complex. The impact of porotic alteration on differential mortality was assessed using Kaplan-Meier survival analysis. The Ward …

The Sound Of Adventure: Two Original Compositions That Combine Music, Sound Design, And Post-Production, Inspired By Outdoor Experiences, Jason K. Gibson

Electronic Theses and Dissertations

Composers have been inspired by nature for centuries, but writing music about nature is becoming more popular in our day. Now, under titles like “Landscape Music” and “Environmental Music,” many composers seek to embody the feeling of nature in music. What has yet to be fully developed is how electronic music and landscape music can overlap in the chamber music world. This project culminates in two original compositions, Natural Opposition (ca. six min), and Giants at Night (ca. 15 min), that seek to satisfy the requirements of both realms by combining naturally inspired music with electronic influences. The compositions themselves …

The Manipulation Of Host Transcription By The Ankh Effector Of Legionella., Juanita E. Von Dwingelo

Electronic Theses and Dissertations

Legionella pneumophila is a Gram-negative facultative intracellular bacterium that can be found dispersed throughout freshwater environments, where it primarily parasitizes amoebae and other protozoan species. Humans are an accidental host for L. pneumophila, and infection occurs upon inhalation of aerosolized water droplets that contain the bacteria. L. pneumophila is the causative agent of Legionnaires’ Disease, which is the result of intracellular proliferation within alveolar macrophages. Pathogenesis of L. pneumophila is dependent on the Dot/Icm type 4 secretion system (T4SS) apparatus, which is comprised of 27 proteins and is responsible for translocating over 330 effector proteins into the host cell. Many …

Non-Invasive Detection And Assessment Of Coronary Stenosis From Blood Mean Residence Times., Javad Hashemi

Electronic Theses and Dissertations

Coronary artery stenosis is an abnormal narrowing of a coronary artery caused by an atherosclerotic lesion that reduces lumen space. Fractional flow reserve (FFR) is the gold standard method to determine the severity of coronary stenosis based on the determination of rest and hyperemic pressure fields, but requires an invasive medical procedure. Normal FFR is 1.0 and FFR RT, to account for varying volume and flow rate of individual segments. Blood_RT was computed in 100 patients who had undergone the pressure-wire FFR procedure, and a threshold for Blood_RT was determined to assess the physiological significance of a stenosis, …

The Effects Of Nicotine And Cigarette Smoking On Cardiac Electrophysiology., Affan B. Irfan

Electronic Theses and Dissertations

Cigarette smoking is a leading cause of preventable disease and premature death worldwide. The adverse effects of cigarette smoking, including proarrhythmia, are related to the mixture of chemicals, including nicotine (which sustains tobacco addiction). However, it remains unclear which individual tobacco smoke constituents and biological pathways mediate this increased risk. The purpose of this research was to explore the chronic effects of cigarette smoking, as well as compare the acute effects of nicotine and cigarette smoking, and the possible role of β-adrenoreceptors, on human cardiac electrophysiology. Chapter 1 is a comprehensive literature review of (a) the ex vivo and in …

Therapeutic Potential Of Withaferin A Against Non-Small Cell Lung Cancer., Al Hassan Kyakulaga

Electronic Theses and Dissertations

Lung cancer is the leading cause of cancer-related deaths worldwide and in the United States. Despite recent advancements in treatment approaches, chemoresistance and metastasis remain a major therapeutic challenge. Withaferin A (WFA), a plant-derived compound has recently emerged as a promising antitumor agent. In the present study, we explored the therapeutic potential of WFA against advanced NSCLC. Briefly, WFA was evaluated for its efficacy, toxicity and pharmacokinetic properties against advanced NSCLC using in vitro and in vivo models. Two human NSCLC cell lines, H1299 and A549 were used in cell culture to determine the anticancer properties of WFA. Repeat dose …

A Recombinant Cholera Toxin B Subunit Variant (Ctb-Kdel) Exhibits Unique Colon Mucosal Healing Effects That Have Therapeutic Implications For Inflammatory Bowel Disease., Joshua Mark Royal

Electronic Theses and Dissertations

This dissertation uncovers the mechanism and explores the utility of a recombinant cholera toxin B subunit (CTB) variant containing a KDEL endoplasmic reticulum (ER) retention motif (CTB-KDEL) as a drug candidate for the treatment of inflammatory bowel disease (IBD). CTB is a mucosal immunomodulatory protein that induces robust mucosal and systemic antibody responses. This well-known biological activity has been exploited in cholera prevention (as a component of Dukoral® vaccine) and vaccine development for decades. On the other hand, several studies have investigated CTB’s immunotherapeutic potential in the treatment of inflammatory diseases such as Crohn’s disease and asthma. Here, we reveal …

Campus Recreation Inclusion For People With Disabilities: A Qualitative Investigation Of Current Inclusive Practices., Tyler C. Spencer

Electronic Theses and Dissertations

This study investigated the current practices of campus recreation professionals to create inclusive campus recreation programs, services, and facilities. The researcher identified twelve campus recreation programs known by their peers and the industry to be at the forefront of providing inclusion efforts to people with disabilities. Through in-depth discussions with campus recreation practitioners at the twelve identified institutions, the investigation elicited a variety of interesting results. Utilizing the frameworks of Critical Disability Theory and Universal Design, this investigation identified how campus recreation practitioners perceive the inclusiveness of their campus recreation departments and how the campus recreation practitioners developed their inclusive …

Gc×Gc-Ms And Parallel 2dlc-Ms Based Untargeted Metabolomics., Md Aminul Islam Prodhan

Electronic Theses and Dissertations

Untargeted metabolomics aims to analyze as many metabolites as possible in a biological system. Due to the vast complexity of the metabolome, bioanalytical platforms have been developed for untargeted metabolomics. While comprehensive two-dimensional gas chromatography mass spectrometry (GC×GC-MS) has been used in different scientific fields, its use in untargeted metabolomics is limited due to several challenges, such as complicated data analysis and limited accuracy of metabolite identification. Two-dimensional liquid chromatography mass spectrometry (2DLC-MS) has also been employed in untargeted metabolomics, but with limited metabolite coverage. This dissertation describes the efforts in developing new data analysis algorithms to improve the accuracy …