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Grey Areas: Songs Of Memory, Imagination, Intellect, And Death For Baritone Voice And Mixed Instrumental Octet, Scott Stephen Hansen
Grey Areas: Songs Of Memory, Imagination, Intellect, And Death For Baritone Voice And Mixed Instrumental Octet, Scott Stephen Hansen
Electronic Theses and Dissertations
The central element of this thesis is Grey Areas, a newly-composed dramatic piece in four movements for baritone and chamber ensemble. The work is highly personal in both its subject matter and its musical execution; it also contains a unique movement order that changes depending on the age of the baritone. Along with the written portion of this document and full score, I completed a studio recording of the entire composition as part of the project. Composers (by necessity) are more frequently functioning as their own recording and mixing engineers for their own works. I have been able to …
-Rhiza., Katherine E. Watts
-Rhiza., Katherine E. Watts
Electronic Theses and Dissertations
-rhiza is a collection of work that focuses on an immersive experience of local ecology and the dichotomous relationship of humanity and nature, presented through the artist's eyes, ecophilosophy, mycology, ecofeminism, and metaphor. An installation of experiential work, -rhiza consists of videography, printmaking, photography, musical elements, both found object and natural item sculptures, and poetry. This compendium of work addresses humanity's apathy towards the ecological imbalance and how this affects our fundamental interconnectedness with all life. Based on explorations of local waterways and the recognition of human consumerism's pressing issues, -rhiza attempts to present the urgent matter of rising …
Pde4 Inhibition: A Novel Therapeutic Strategy In Liver Fibrosis., Mohamed Elnagdy
Pde4 Inhibition: A Novel Therapeutic Strategy In Liver Fibrosis., Mohamed Elnagdy
Electronic Theses and Dissertations
Background: Liver fibrosis is accumulation of extracellular matrix (ECM) proteins due to chronic liver injury. Chronic hepatic damage can occur due to multiple causes including, alcohol, non-alcoholic steatohepatitis and chronic viral hepatitis. Liver fibrosis is a critical problem worldwide due to the extremely high incidence of alcohol associated liver damage and chronic viral hepatitis. Moreover, there is no FDA approved therapy for liver fibrosis. Activation and transdifferentiation of quiecent hepatic stellate cells (HSCs) to myofibroblasts (MFBs) is the main event contributing to liver fibrosis. This process involves two phases, the initiation and the perpetuation phases. Hepatocyte injury and inflammatory response …
Resonating Otherness: Rethinking The Body Through Octavia Butler's Dawn., Tristan Dewitt Carr
Resonating Otherness: Rethinking The Body Through Octavia Butler's Dawn., Tristan Dewitt Carr
Electronic Theses and Dissertations
This thesis focuses on the intersection between sound and bodies as a way of re-envision the concept of human, using Octavia Butler’s Dawn as a case study. Specifically, this study contends that Butler’s re-envisioning is sonic, imagining the concept of self as it is understood by Jean-Luc Nancy’s idea of the “resonant subject,” in that sound embroils us within our environment. This sonic, resonant body is revealed in Dawn through Butler’s adaption of Roland Barthes’ concept of “grain,” which is not merely embodied sound, but the result of artifice – a carefully crafted “slip” that allows for a way of …
Improvised Power: Finding An Authentic Acting Aesthetic In An Adaption Of Mowatt's Fashion., Alexander Louis Gordon
Improvised Power: Finding An Authentic Acting Aesthetic In An Adaption Of Mowatt's Fashion., Alexander Louis Gordon
Electronic Theses and Dissertations
This thesis elaborates on how my process, which I call Mindsets, was developed and utilized to play Count Jolimaitre in the Spring 2021 UofL Department of Theatre Arts online production of [Re]Fashion, an adaptation of Anna Cora Mowatt’s Fashion by Dr. J. Ariadne Calvano, Dr. Janna Segal, and Blair Potter. I used improvisatory acting techniques to develop this character from Mowatt’s mid-19th-century play, as crafted and produced during the COVID-19 pandemic. In this thesis, I explore how continuous physical exploration enabled me to navigate a new rehearsal process. I will explain how I attempted to create a character that was …
Heterocyclic Amines And Arylamine N-Acetyltransferase 2 Polymorphism In Pathogenesis Of Insulin Resistance., Kennedy M. Walls
Heterocyclic Amines And Arylamine N-Acetyltransferase 2 Polymorphism In Pathogenesis Of Insulin Resistance., Kennedy M. Walls
Electronic Theses and Dissertations
Heterocyclic amines (HCAs) are formed when cooking meats at high temperatures or for long periods of time, and their major metabolic pathway includes hepatic N‑hydroxylation by CYP1A2 followed by O-acetylation by N-acetyltransferase 2 (NAT2). NAT2 is a highly polymorphic gene involved in metabolism of drugs and xenobiotics, and its single nucleotide polymorphisms (SNPs) produce phenotypes characterized as slow, intermediate, or rapid acetylator. Recent studies have documented associations between HCAs and insulin resistance and between certain NAT2 phenotypes and insulin resistance. In this study, we demonstrated that NAT2 activity and exposure to certain HCAs may alter cellular glucose …
Habitation And Interaction In The Lower Illinois River Valley: A Case Study On Household Structure And Ceramics At The German Site (11c377)., Catherine Zoe Doubles
Habitation And Interaction In The Lower Illinois River Valley: A Case Study On Household Structure And Ceramics At The German Site (11c377)., Catherine Zoe Doubles
Electronic Theses and Dissertations
The purpose of this project is to investigate the less understood narrative of the Late Woodland peoples at the German site within the Lower Illinois River Valley. In order to determine the extent of Mississippian cultural interaction with the Jersey Bluff Phase, Late Woodland, peoples, I will examine the houses and artifacts found during the 2019 field season by the Centre for American Archeology. Data from the geophysical surveys, notes from the site excavations, and ceramic analysis will be used to place the German site within the theoretical framework and archaeological context of the region. In the end, the objective …
Prageru As A Parasite Public., Ryan A Corso-Gonzales
Prageru As A Parasite Public., Ryan A Corso-Gonzales
Electronic Theses and Dissertations
This thesis examines the media corporation PragerU as a parasite public, using the framework provided by Larson and McHendry (2019). Parasitic publics are “reactionary discursive spaces formed residual and institutionalized affectively through the invention, circulation and uptake of demagogic rhetorics” (Larson & McHendry, 2019, p. 517). The purpose of this thesis is to identify and analyze the argumentative tactics used by PragerU in the public sphere. I argue that PragerU utilizes its extensive network to resist counterpublicity and influence the dominant public sphere. This thesis demonstrates the ways in which this PragerU utilizes its unique position in the public sphere …
Presence Of Severe Acute Respiratory Syndrome Coronavirus 2 In Urban Streams Receiving Sewer Overflow, Louisville, Kentucky, Usa., Cullen Hunter
Presence Of Severe Acute Respiratory Syndrome Coronavirus 2 In Urban Streams Receiving Sewer Overflow, Louisville, Kentucky, Usa., Cullen Hunter
Electronic Theses and Dissertations
Pathogens may enter surface waters as they are shed in human feces and potentially delivered to surface waters via sewer overflows, particularly in the eastern United States. This study examined of the presence of fecal indicators in two forks of Beargrass Creek in Louisville, Kentucky. Surface water grab samples (N=30), sediment samples, water quality, and a paired wastewater surveillance study were analyzed. SARS-CoV-2 was detected in a single stream sample despite ubiquitous presence of the virus within the area in wastewater and consistent evidence of a human fecal indicator. These findings demonstrate the need for more green and gray infrastructure …
Saving Butterflies In The City: Gardens As Conservation Spaces In Urban Landscapes., Lindsay D. Nason
Saving Butterflies In The City: Gardens As Conservation Spaces In Urban Landscapes., Lindsay D. Nason
Electronic Theses and Dissertations
Butterfly populations are declining, and habitat degradation due to urbanization is a major contributing factor. Gardens represent a large proportion of land area in many cities, and thus may be important for conserving butterflies in urban environments. In this dissertation, I examine how garden features (ex: size, level of urbanization, plant diversity) affect adult butterfly diversity/abundance, behavior, and the predation risk faced by caterpillars. My study sites were native plant gardens in Jefferson, Bullitt, and Hardin Cos.,KY. In Chapter One, I used clay caterpillars to assess differences in predation pressure in gardens along a gradient of percent impervious surface (%IS). …
Harmful Algal Blooms In The Ohio River: Spatial And Temporal Differences., Bevin Hardy
Harmful Algal Blooms In The Ohio River: Spatial And Temporal Differences., Bevin Hardy
Electronic Theses and Dissertations
The frequency of harmful algal blooms (HABs) has been increasing across the globe, especially in river ecosystems. Although more common in lakes, more HABs have been reported in rivers in the past decade, particularly in the Ohio River. In 2019, a HAB stretched 200 to 300 miles throughout the Ohio River from September to October. Samples were collected for the duration of the 2019 bloom (August-October) in the McAlpine Pool in Louisville, KY to compare microcystis toxin (microcystin) concentrations on a temporal and spatial scale. Different habitats (bay, creek, river) were sampled throughout the bloom, and two additional sampling days, …
The Peacock In The Room: Confronting The Hidden Curriculum Of Androcentrism And Gender Bias In Undergraduate Biology Education., Sarah Hamilton Spaulding
The Peacock In The Room: Confronting The Hidden Curriculum Of Androcentrism And Gender Bias In Undergraduate Biology Education., Sarah Hamilton Spaulding
Electronic Theses and Dissertations
This dissertation exposes one manifestation of the hidden curriculum of gender bias in the biological academe and explores the impacts of implicit essentialist perspectives on biology curricula and student understanding of an important evolutionary concept. Chapter one introduces the concept of gender essentialism and its relationship to the hidden curriculum of gender bias. I conclude the introductory chapter by reviewing tenets from queer curriculum theory and suggesting that applications of the theory may provide educators with the pedagogical tools required to counter implicit essentialist perspectives. Chapter two describes a textbook image analysis informed by previous textbook analyses to examine the …
Determination Of The Biological Functions Of Undefined Domains Of Veev Nsp2., Andrew Michael Skidmore
Determination Of The Biological Functions Of Undefined Domains Of Veev Nsp2., Andrew Michael Skidmore
Electronic Theses and Dissertations
Alphaviruses are positive sense, single strand, RNA viruses. These viruses occur on every populated continent. Alphaviruses are divided into two clades, the New-World and Old-World viruses. The New-World viruses include Eastern (EEEV), Western (WEEV), and Venezuelan equine encephalitis viruses (VEEV), and cause neuroinvasive disease. The Old-World viruses include Chikungunya (CHIKV) and Ross River viruses (RRV), and typically cause multijoint arthralgia. There are currently no approved antiviral therapeutics or vaccines for any alphavirus, making them a high priority for antiviral drug design and discovery. A benzamidine inhibitor (ML336) of VEEV was characterized, and determined to inhibit replication of VEEV RNA during …
Genetic And Functional Analysis Of Rat Mammary Cancer Susceptibility., Emily L Duderstadt
Genetic And Functional Analysis Of Rat Mammary Cancer Susceptibility., Emily L Duderstadt
Electronic Theses and Dissertations
Breast cancer genetic susceptibility is modulated by high to low penetrance risk alleles. Population frequencies of high and moderate penetrant predisposing mutations are rare and responsible for a small percentage of population cases. Most genetic variation in breast cancer susceptibility is low penetrance common variants where causal genes and risk-associated mechanisms are largely unknown. Comparative genetics uses animal models to isolate and mechanistically evaluate genetic susceptibility to human disease. Rat strains have different susceptibility phenotypes to chemical-induced carcinogenesis. Selective breeding and genetic linkage analysis using a 7,12-dimethylbenz(a)anthracene (DMBA) rat mammary carcinogenesis model have identified Mammary carcinoma susceptibilityquantitative trait loci …
Shifting Sands., Rachid Tagoulla
Shifting Sands., Rachid Tagoulla
Electronic Theses and Dissertations
Shifting Sands is a re-exploration of the presentation of North Africans in colonial postcards, an examination of identity, and a critique of the modern Western museum. Since the inception of photography, colonizers used this medium- especially in the form of postcards- to categorize and exoticize Eastern peoples in order to more easily subjugate them. Shifting Sands is a series of reconstructed colonial postcards which challenges colonial-era stereotypes of North African peoples. The colonial gaze, represented by the camera lens, is subverted through a lensless image-making process in which sand is used to remove the subject from the colonial gaze and …
Isomotive Dielectrophoresis For Enhanced Analyses Of Cell Subpopulations., Mohamed Zakarya Rashed
Isomotive Dielectrophoresis For Enhanced Analyses Of Cell Subpopulations., Mohamed Zakarya Rashed
Electronic Theses and Dissertations
As the relentless dream of creating a true lab-on-a-chip device is closer to realization than ever before, which will be enabled through efficient and reliable sample characterization systems. Dielectrophoresis (DEP) is a term used to describe the motion of dielectric particles/ cells, by means of a non-uniform electric field (AC or DC). Cells of different dielectric properties (i.e., size, interior properties, and membrane properties) will act differently under the influence of dielectrophoretic force. Therefore, DEP can be used as a powerful, robust, and flexible tool for cellular manipulation, separation, characterization, and patterning. However, most recent DEP applications focus on …
Distribution And Ecological Effects Of Azteca Chartifex/Trigona In The Barro Colorado Nature Monument., Rachel Leann Wells
Distribution And Ecological Effects Of Azteca Chartifex/Trigona In The Barro Colorado Nature Monument., Rachel Leann Wells
Electronic Theses and Dissertations
This dissertation explores the behavior and ecology of a conspicuous and behaviorally dominant ant species in the tropical rainforest of Panama. Competition with aggressive species is an important factor that shapes local community structure. Eavesdropping on the chemical communication systems of such behaviorally dominant species can help heterospecific species to avoid negative interactions. I review the chemical communication system and known ecological effects of the Neotropical canopy ant, Azteca chartifex/trigona (Chapter 1). There are over 40 known compounds produced by Azteca workers, yet how these compounds impact heterospecific species is unclear in many circumstances. I assessed if heterospecific …
In Bloom: Nurturing The Liberation Process Of Performer And Character As Rose In August Wilson's Fences., Paula O. Lockhart
In Bloom: Nurturing The Liberation Process Of Performer And Character As Rose In August Wilson's Fences., Paula O. Lockhart
Electronic Theses and Dissertations
Rose Maxson is the 43-year-old matriarch of the Maxson household in August Wilson’s Pulitzer Prize-winning play, Fences. She is a character with an inviolable spirit. The unwavering force she possesses rattles the pages as she relives past loves, loss, experiences heartbreak. Imagine, how I, a then 24-year old devoid of the immense life experience that Rose encompasses found my way into her. The answer is through nurture. To nurture is a process of feeding, protecting, or rearing someone or something. It is a journey with or without a destination. Rose is in a constant state of nurturing her family, …
Development And Applications Of In-Vitro And In-Silico Models Of The Cardiovascular System To Study The Effects Of Mechanical Circulatory Support., Moustafa Meki
Electronic Theses and Dissertations
Cardiovascular diseases (CVDs) are the leading cause of mortality globally. With ongoing interest in CVDs treatment, preclinical models for drug/therapeutic development that allow for fast iterative research are needed. Owing to the inherent complexity of the cardiovascular system, current in-vitro models of the cardiovascular system fail to replicate many of the physiological aspects of the cardiovascular system. In this dissertation, the main concern is with heart failure (HF). In advanced HF, patients may receive Left Ventricular Assist Devices (LVADs) as a bridge to transplant or destination therapy. However, LVADs have many limitations, including inability to adapt to varying tissue demand …
Assessing The Role Of Chronic Arsenite Exposure In Disrupting The Egfr Signaling Axis., Christine Kim
Assessing The Role Of Chronic Arsenite Exposure In Disrupting The Egfr Signaling Axis., Christine Kim
Electronic Theses and Dissertations
Chronic arsenic exposure is a risk factor for the development of pulmonary diseases, including lung cancer, but the exact mechanism is not yet fully understood. Many previous studies have relied on acute arsenic exposure (i.e. 1-10 uM arsenic for 24 hours) to study arsenic toxicological effects. However, acute exposure does not reflect the levels or duration of arsenic associated with environmental exposure, or drinking of contaminated well water. This dissertation differentiates the effects of acute versus chronic arsenic exposures on the EGFR signaling axis and suggests possible mechanisms for chronic arsenic-induced pulmonary diseases. The EGFR is a receptor tyrosine kinase …
Mapping Three Dimensional Interactions Between Biomolecules And Electric Fields., Joseph Patrick Brian P.E.
Mapping Three Dimensional Interactions Between Biomolecules And Electric Fields., Joseph Patrick Brian P.E.
Electronic Theses and Dissertations
Electroporation is a technique that induces the formation of open pores in cell membranes by the application of an electric field. Electroporation is widely practiced in research and clinical work for transfection of genetic sequences and drug molecule transport through the membrane barrier. However, a full theoretical explanation of the molecular mechanisms and thermodynamics responsible for pore formation, structure, and longevity does not yet exist. Advances in molecular dynamics simulations have enabled theoretical studies of electroporation with previously unobtainable fidelity spanning biologically relevant timescales. All-atom simulations utilizing the recently developed method of computational electrophysiology demonstrate that pore size correlates to …
Simulation Of Fracture Strength Improvements Of A Human Proximal Femur Using Finite Element Analysis., Waleed Ebraheem Alim
Simulation Of Fracture Strength Improvements Of A Human Proximal Femur Using Finite Element Analysis., Waleed Ebraheem Alim
Electronic Theses and Dissertations
The most common hip fracture in the elderly occurs as a result of a fall to the side with impact over the greater trochanter resulting in a fracture of the proximal femur. The fracture usually involves the femoral neck or the intertrochanteric region. It has recently been determined that the fracture crack of a hip fracture typically initiates on the superior-lateral cortex of the femoral neck and then propagates across the femoral neck, resulting in a complete fracture. The strength of the superior-lateral cortex of the femoral neck is likely determined by the combined properties of the generally thin cortex …
The Importance Of Noncapped Viral Genomic Rna To Alphaviral Infection And Pathogenesis., Autumn Lapointe
The Importance Of Noncapped Viral Genomic Rna To Alphaviral Infection And Pathogenesis., Autumn Lapointe
Electronic Theses and Dissertations
Alphaviruses are mosquito-borne arboviruses that have a positive sense, single-stranded RNA genome, which are capable of causing severe disease and thus pose a significant burden to public health. During alphaviral replication, significant quantities of viral genomic RNAs that lack the canonical alphaviral 5’ cap structure are produced and packaged into viral particles, despite the fact that these noncapped genomes cannot be translated and are essentially noninfectious. The production and packaging of the noncapped genomes has been found to be true for infections across multiple vertebrate and invertebrate cell lines and alphavirus species, although the proportion of ncgRNA produced differs. Despite …
Role Of Kvβ2 Subunits In Regulation Of Resistance Arterial Tone., Sean M Raph
Role Of Kvβ2 Subunits In Regulation Of Resistance Arterial Tone., Sean M Raph
Electronic Theses and Dissertations
Voltage-gated potassium (Kv) channels control vascular resistance and facilitate the augmentation of myocardial blood flow in response to increases in cardiac workload (i.e., metabolic hyperemia). Native sarcolemmal Kv1 channels in arterial myocytes associate with a heteromeric auxiliary complex consisting of intracellular Kvβ1 and Kvβ2 proteins. The Kvβ proteins differentially regulate the function of heterologously expressed Kv channels, as well as native Kv1 channels in excitable cells of the cardiovascular and nervous systems. The physiological importance of vascular Kvβ proteins in mediating vasodilation remains unknown. In this study, I tested the hypothesis that Kvβ proteins functionally regulate vascular tone in response …
Preclinincal Development Of Avaren-Fc: A Novel Lectin-Fc Fusion Protein Targeting Cancer-Associated High-Mannose Glycans., Matthew William Dent
Preclinincal Development Of Avaren-Fc: A Novel Lectin-Fc Fusion Protein Targeting Cancer-Associated High-Mannose Glycans., Matthew William Dent
Electronic Theses and Dissertations
This dissertation explores the anticancer activity of Avaren-Fc (AvFc), a novel lectin-Fc fusion protein or “lectibody” targeting cancer and virus-associated high-mannose glycans. Previously, we have shown that AvFc recognizes a broad selection of established cancer cell lines from a wide array of tissue types, can potently induce antibody-dependent cell-mediated cytotoxicity (ADCC) against them, and exhibits anti-cancer activity in vivo. However, the exact mechanism of action remains elusive. We hypothesized that the primary mechanism of action is through Fc-mediated effector functions, and the purpose of this dissertation is to explore this question through the use of Fc variants that either …
Becoming Culturally Responsive: A Guide For Music Educators., Bailey Haynes
Becoming Culturally Responsive: A Guide For Music Educators., Bailey Haynes
Electronic Theses and Dissertations
As America sees an increase in minority groups, providing an education that is beneficial and responsive to all cultures is a growing focus in the education system. One of the many roles of a music educator is to expose students to allmusic and music that is most meaningful to the students. Music educators are charged with providing students with musical instruction that is well rounded, and that will aid in the personal and educational growth of learners. Through culturally responsive teaching, defined as “a research-based approach towards teaching that connects students’ cultures, languages, and life experiences with that they …
Harnessing The Power Of Trained Immunity In The Setting Of Pancreatic Cancer: A Novel Mechanism Of Immune Trafficking And Tumor Control., Anne Elena Geller
Harnessing The Power Of Trained Immunity In The Setting Of Pancreatic Cancer: A Novel Mechanism Of Immune Trafficking And Tumor Control., Anne Elena Geller
Electronic Theses and Dissertations
Despite the success of immunotherapy in many types of cancer, pancreatic adenocarcinoma (PDAC) has yet to benefit. Innate immune cells are critical to antitumor immunosurveillance and recent studies have revealed that these populations possess a form of memory, termed trained innate immunity, which occurs through transcriptomic, epigenetic, and metabolic reprograming. Though trained innate immunity has mostly been investigated in the context of infection, the induction of trained innate immunity could also protect against tumors, and specifically pancreatic tumors. Here, we demonstrate that yeast-derived particulate β-glucan, a known inducer of trained immunity, traffics to the pancreas following IP administration. This causes …
Ecological, Evolutionary, And Molecular Mechanisms Driving Pyocin Diversity In Pseudomonas Aeruginosa., Aubrey A. Mojesky
Ecological, Evolutionary, And Molecular Mechanisms Driving Pyocin Diversity In Pseudomonas Aeruginosa., Aubrey A. Mojesky
Electronic Theses and Dissertations
Bacteriocins are narrow-spectrum antibiotics produced in nearly all lineages of bacteria, meaning that these antimicrobials target closely related individuals. The bacteriocins of Pseudomonas aeruginosa, called pyocins, are highly prevalent and diverse in populations of this species. Laboratory studies have shown that pyocins can function to mediate the outcome of interactions, often allowing for the coexistence of multiple strains, as no one pyocin genotype is competitively superior. Although this has been demonstrated under laboratory conditions, the function of pyocins in natural settings and the ecological, evolutionary, and genetic mechanisms underlying pyocin diversity remains unclear. As such, for my dissertation, I …
Identifying The Cardiovascular Effects Of Multiple Pollutants., Katlyn Elizabeth Mcgraw
Identifying The Cardiovascular Effects Of Multiple Pollutants., Katlyn Elizabeth Mcgraw
Electronic Theses and Dissertations
Cardiovascular disease (CVD) is the leading cause of death from environmental exposures. Although exposure to PM2.5 is an established risk factor for CVD, the contribution of other hazardous pollutant exposure to CVD is less clear. Overall, this work aimed to examine the effect of pollutants with lesser documented effects on cardiovascular disease using a multi-pronged approach to exposure assessment. The three aims were to examine the relationship between county-level toxic chemical releases and CVD mortality in the contiguous United States between 2002 and 2012, to assess the relationship between individual-level VOC metabolites and vascular function, and to build multipollutant …
A Home For Friendless Women With Critical Essay "But What Was She Wearing?", Kelly E. Hill
A Home For Friendless Women With Critical Essay "But What Was She Wearing?", Kelly E. Hill
Electronic Theses and Dissertations
This dissertation is a historical novel accompanied by a critical lyric essay. Through a combination of scholarly research and creative activity, the novel reimagines the lives of the women who lived as inmates and administrators in the Home for Friendless Women, a charity home that operated in Louisville in the late nineteenth century. The critical essay draws from my interdisciplinary background to combine personal experiences, archival and scholarly research, and literary analysis to connect the U.S. dress reform movement in the 1850s, and its failure to change public perception about what was acceptable attire for middle and upper class women, …