Digital Commons Network^™

Targeting Strategies To Optimize The Therapeutic Potential Of Gold Compounds Against Her2-Positive Breast Cancers, Afruja Ahad

Dissertations, Theses, and Capstone Projects

The overexpression of HER2 accounts for 20-30% of breast cancer tumors and not only serves as a marker for poor predictive clinical outcomes but also as a target for treatment. Antibody-drug conjugates (ADCs) combine the selectivity of monoclonal antibodies (mAbs) with the efficacy of chemotherapeutic drugs to provide targeted treatment without toxicity to normal tissue. Most of the ADCs currently in the clinic for cancer chemotherapy are based on complex organic molecules. In contrast, the conjugation of metallodrugs to mAbs has been overlooked when there is enormous potential in this area with the resurgence of metal-based drugs as prospective cancer …

Methamphetamine-Induced Dna Double-Stranded Breaks: The Impact Of The Dopamine Transporter And Insights Into The Mechanisms Of Dna Damage In Mouse Neuro 2a Cells, Lizette Couto

Dissertations, Theses, and Capstone Projects

Methamphetamine (METH) abuse remains a global health concern, with emerging evidence highlighting its genotoxic potential. In the central nervous system METH enters dopaminergic cells primarily through the dopamine transporter (DAT), which controls the dynamics of dopamine (DA) neurotransmission by driving the reuptake of extracellular DA into the presynaptic neuronal cell. Additional effects of METH on the storage of DA in synaptic vesicles lead to the dysregulated cytosolic accumulation of DA. Previous studies have shown that after METH disrupts intracellular vesicular stores of DA, the excess DA in the cytosol is rapidly oxidized. This generates an abundance of reactive oxygen species …

Values In Evidence-Based Policy: Bridging Socio-Political, Moral, And Epistemic Domains, Karyna Pryiomka

Dissertations, Theses, and Capstone Projects

Values constitute an inescapable constant of any policymaking or evidence-production process. In this dissertation I explore ways in which socio-political, moral, and epistemic values inform evidence production and use in public higher education policy. In “Chapter One: Introduction and Literature Review”, I provide a brief overview of evidence-based policy as a practice. I then discuss three major categories of values, focusing on higher education examples whenever possible. Finally, I present the central study of this dissertation. The central question of my dissertation is In what ways do epistemic, socio-political, and moral values frame the production and deployment of evidence in …

The Divided Self: Internal Conflict In Literature, Philosophy, Psychology, And Neuroscience, Yulia Greyman

Dissertations, Theses, and Capstone Projects

This thematic project examines the notion of self-division, particularly in terms of the conflict between cognition and metacognition, across the fields of philosophy, psychology, and, most recently, the cognitive and neurosciences. The project offers a historic overview of models of self-division, as well as analyses of the various problems presented in theoretical models to date. This work explores how self-division has been depicted in the literary works of Edgar Allan Poe, Don DeLillo, and Mary Shelley. It examines the ways in which artistic renderings alternately assimilate, resist, and/or critique dominant philosophical, psychological, and scientific discourses about the self and its …

A Candidate Needs Approach To Job Advertisements, Yuliya M. Cheban-Gore

Dissertations, Theses, and Capstone Projects

Organizations currently lack research-based best practice guidance on what information is most helpful for job seekers when deciding which jobs and organizations to apply to. This lack of guidance is a detriment because, typically, recruitment strategies are designed from the perspective of the organization’s needs –which is effective when the job market is organization, rather than candidate-driven. When the market is candidate-driven, it would benefit organizations to view the recruitment process through the lens of job seekers. The current studies focus on understanding one of the beginning stages of recruitment through the lens of job seekers: job advertisements. Through a …

The Role Of Glutamate In The Medial Prefrontal Cortex In The Acquistion And Expression Of Conditioned Approach, Rudolf Nisanov

Dissertations, Theses, and Capstone Projects

A series of experiments were conducted to assess the role of glutamatergic stimulation in the dorsal and ventral regions of the medial prefrontal cortex (mPFC) in both the acquisition and expression of reward-related learning using a Pavlovian conditioning paradigm, the conditioned-approach paradigm. Rats with surgically implanted cannulas were exposed to Pavlovian conditioning sessions that occurred on three alternative days (acquisition) or seven consecutive days (expression). These 60-min conditioning sessions consisted of 30 pairings of light (CS) and food pellets (US) presented under a random time schedule. After a two-day break, rats underwent a session with no CS or US and …

Interracial Instagram: Depictions Of Interracial Couples On Instagram, Christie Sillo

Dissertations, Theses, and Capstone Projects

This dissertation examines depictions of interracial romantic relationships on Instagram, a popular photo- and video-sharing social networking site. Social networking sites like Instagram, whereby users connect with each other by creating, sharing, and consuming content, are prime sites for sociological study because ideas are constantly being (re)made on them. On Instagram, meaning-making is mainly done through the construction of a profile and the posting of images and/or videos. Using a mixed-methods research design of hashtag analysis, digital ethnography, discourse and image analysis, I critically analyze Instagram profiles that depict interracial romantic relationships. In doing so, I develop a contemporary, social …

Racial-Sexual Normativity In/As Narratives Of “The Human”, Jeri Brand

Dissertations, Theses, and Capstone Projects

This thesis synthesizes Sylvia Wynter’s and Judith Butler’s models of identity-formation to analyze discourses of racialization and sex/gender difference in normative scientific theories of “the human.” I argue that eugenicist white supremacism and sex/gender normativity form a single conceptual framework – what I call “the racial-sexual matrix” – throughout these scientific narratives. I then trace an epistemological consistency across 18^th- through 21^st-century scientific literature as evidence for the ongoing legacies of coloniality, white supremacy, and eugenics in current hegemonic sex/gender ontologies. Finally, I contend that the racial-sexual matrix functions as an index of proper humanness not …

Cancer In Pajamas: Radio, Podcasts, And The Politics Of Free Time In The Digital Age, Daniel Grjonko

Dissertations, Theses, and Capstone Projects

The podcast, an extremely potent fermentation of the radio which was so central to many of the Frankfurt School thinkers, is an important political subject to consider in light of rekindled social discussions concerning a society straddling the line between fascism and socialism. Especially the political podcast, which has become a pulse of intellectual discussion and historical analysis, promises itself simultaneously as a medium of entertainment, pedagogy, and translation into real-world organizing for a different world, true for both the left and the right. The truth, I propose, is a sinister other experience, one which maintains the status quo …

Galina Ustvolskaya's Writing For Violin And Piano, 1952–1964, Patrick Doane

Dissertations, Theses, and Capstone Projects

Galina Ustvolskaya, Russian composer born in 1919 in Petrograd, navigated a life amidst the tumultuous changes in Soviet-era music and the upheavals of her home city. This dissertation explores Ustvolskaya’s compositions for violin and piano, to deepen the understanding of her musical language and style.

Despite the constraints and challenges imposed by the era’s political landscape, Ustvolskaya boldly crafted a distinct musical identity, writing social-realist compositions while privately cultivating a highly complex, individual style.

Few scholars have undertaken a comprehensive look at her music. This dissertation contributes to a growing body of recent scholarship by employing Russian music theorist Valentina …

Hagia Sophia: Politics Of Space And Hauntology, Hazal Demir

Dissertations, Theses, and Capstone Projects

Hagia Sophia is one of the most celebrated cultural heritages, considered sacred for thousands of years. However, Hagia Sophia’s political dimension is often overshadowed by its religious-sacred meanings. This thesis aims to analyze Hagia Sophia’s political character through four pivotal historical events: its foundation by Justinian the Great, its conversion into the imperial mosque of the Ottoman Empire, its secularization under the Turkish Republic, and its subsequent reconsecration into a mosque in 2020. Focusing on these four historical milestones, this thesis illuminates a political pattern embedded in Hagia Sophia, emphasizing its role as a space of political legitimacy and ideological …

"My First Best Love": Women's Writing On College Friendships 1880–1905, Alyssa J. Kayser-Hirsh

Dissertations, Theses, and Capstone Projects

In the late nineteenth and early twentieth century, American society encouraged strong bonds between women. As separate sphere ideology took hold, highly-structured female relationships were created and maintained through shared rituals, language, and expectations. The resulting friendships enabled women to build a range of emotional ties with one another. At the same time, an expanding array of gender segregated educational institutions further promoted homosocial networks. Women’s college students built community through their shared experience inhabiting a collective space, forging social circles as well as one-on-one intimate relationships. This thesis examines women’s experiences of friendship within the college setting between 1880 …

Trees In Urban Environments: How Soil Quality Impacts Tree Performance, Saidan Qi

Dissertations, Theses, and Capstone Projects

Cities around the world are increasingly investing in reforestation and afforestation efforts to mitigate impacts from climate change and population growth. However, urban soil conditions can be unfavorable for tree growth. Street trees are widely known to suffer from poor soil quality, but there has been no comprehensive review of this topic so far. Clean soils can be transported from nonurban areas to support cities’ green projects, but this approach is not sustainable. Artificial (constructed) soils can be created from various materials and have been proposed as an alternative medium for urban tree growth, but no research has been done …

Epistemic Theatres: The Dramaturgy Of Knowledge In Twenty-First Century Theatre, Amir Farjoun

Dissertations, Theses, and Capstone Projects

In this dissertation, I draw upon theatre and performance literature, science and technology studies, and art theory to attend the distinctive dramaturgical features of lecture-performance and other contemporary examples of epistemic theatres. After theorizing their roots, their causes, and their objectives, I build on the intrinsic and mutual links these performances develop between theatre and knowledge to justify and develop novel academic modes of response that consider theatre as a method, and not merely an object, of humanistic study. I propose that a theatricalization of knowledge—or rather, a more explicit acknowledgement of knowledge’s engrained theatricality—helps in developing intellectual-academic responses not …

Comparative Animal Mucomics, Antonio R. Cerullo

Dissertations, Theses, and Capstone Projects

Mucus is one of Nature’s most abundant and versatile biomaterials. These secretions are present in all animals, from the lowly garden snail to the great blue whale, and fulfill a multitude of functions, acting as antimicrobial barriers, moisturizers, adhesive glues, surface lubricants, and mineralizing agents. Despite their importance, very little is known about mucus compositions or properties. The largest challenge precluding the greater understanding of mucus function is its complexity; a single mucus contains complex mixtures of proteins, glycans, and ions that all have important roles in function. Therefore, understanding mucus function necessitates analysis that compares different mucus from one …

A Pearl Ravaged: The Paradox Of Haiti And Its Socioeconomic Origins, Isabel Ishibe Exel

Dissertations, Theses, and Capstone Projects

Saint-Domingue was once the most profitable colony of the Caribbean, the so-called pearl of the Antilles. Nowadays, Haiti is known for being the poorest country in the Western Hemisphere, a dramatic shift that raises the question of the factors contributing to Haiti's current state, marked by persistent violence, natural disasters, and political instability. Various discourses have framed Haiti as a country doomed for failure. However, relying on binary concepts such as success and failure is counterproductive to a refined analysis. How, then, should we structure this conversation? My ultimate goal for this work is to provide a nuanced analysis of …

Interviews And Perspectives Among Community Members Working With Undocumented Female Border Crossers In The States Along The United States-Mexico Border, Melissa M. Frasco

Dissertations, Theses, and Capstone Projects

In order to discuss immigration in the context of the United States, we must dispel the myth that immigration is monolithic. Therefore, when we discuss national identity, gender equality, policy, employment rates, and countless other ordinary topics, we are discussing immigration, as it is embedded in our history and our future. The goal of my research is to delineate the experiences of violence that female border crossers undergo in the process of crossing into the United States via the southernmost border. The data collection process involved four semi-structured interviews to collect oral histories from workers at community-based organizations. These organizations …

The Black Map Project: A Black People’S Epistemology Of Healing, Britton Williams

Dissertations, Theses, and Capstone Projects

This work is a love letter to Mary Turner and her descendants, by which I mean all Black people, that lifts recipes and roadmaps of Black creative healing and liberatory praxes. It is a freedom dream (Kelley, 2002) that dares to (re)imagine mental health care by holding Black healing and liberation centrally in mind. I do not seek to prove through this work but rather to provoke [thought|action|repair]. In this work, I unsettle prescribed notions of therapy that have long dismissed/erased/ignored the needs and [therapeutic] practices of Black people. The Black MAP Project resists epistemologies of ignorance (Mills, 2022)—born in …

Evaluating The Reliability And Accuracy Of Alchemical Binding Free Energy Methods And Calculations, Fnu Sheenam

Dissertations, Theses, and Capstone Projects

Molecular recognition plays a crucial role in various biological processes, such as enzymatic reactions, signal transduction, and genetic information processing. Investigating how proteins selectively bind to their partners is an active research area, but there is a lack of experimental details on protein structures and interactions in molecular complexes. Computational techniques based on macromolecular structures offer a way to predict protein-ligand interactions and explore their recognition mechanisms. Estimating binding affinities, particularly through alchemical binding free energy calculations, has become valuable in supporting drug discovery. This work introduces new methodologies, utilizing the Alchemical Transfer Method, to address issues like poor convergence …

Essays In Macroeconomics And Finance, Archil Dvalishvili

Dissertations, Theses, and Capstone Projects

Chapter 1: (A Quantitative Analysis of Interest on Reserves and Reserve Requirements) - I construct a medium scale DSGE model with financial frictions both on the demand (entrepreneurs) and supply (banks) sides of credit to study the costs and benefits of fixed/time-varying minimum reserve requirements and interest paid by the Fed on reserves.The results can be summarized as follows: (1) An optimal time-varying minimum reserve requirement generates substantial welfare gain when compared with a fixed minimum reserve requirement when no interest is paid on reserves. (2) Paying interest on reserves is substantially welfare inferior to a policy with no interest …

Rational Design Of Peptide-Based Materials Informed By Multiscale Molecular Dynamics Simulations, Dhwanit Rahul Dave

Dissertations, Theses, and Capstone Projects

The challenge of establishing a sustainable and circular economy for materials in medicine and technology necessitates bioinspired design. Nature's intricate machinery, forged through evolution, relies on a finite set of biomolecular building blocks with through-bond and through-space interactions. Repurposing these molecular building blocks requires a seamless integration of computational modeling, design, and experimental validation. The tools and concepts developed in this thesis pioneer new directions in peptide-materials design, grounded in fundamental principles of physical chemistry. We present a synergistic approach that integrates experimental designs and computational methods, specifically molecular dynamics simulations, to gain in-depth molecular insights crucial for advancing the …

Without Us There Is No Britain: Black British Photography And Film Networks, 1950-1989, Maria T. Quinata

Dissertations, Theses, and Capstone Projects

This dissertation tracks three moments from 1950 to 1989, when images were put to work by Black photographers and filmmakers to stake individual and communal claims to Britain and Britishness: first, through the emergence of photographic portraiture taken in domestic living spaces during the 1950s to 1970s; second, through the Black Panther Movement and their use of photography in the late 1960s to mid 1970s, and last, with the efflorescence of Black film and video collectives in the 1980s. At each of these moments, I attend to the simultaneous production, negotiation, and co-mingling of new social identities that were diasporic, …

Algorithmic Love: Twenty-First Century Organizations Of The Romantic, Sandra Moyano Ariza

Dissertations, Theses, and Capstone Projects

This dissertation investigates the highly computed and accelerated experiences of digital love as well as their cultural and artistic representations in order to shed light on the human and more-than-human entanglements producing the algorithmic love experience. The recent turn to love in critical theory and cultural studies examines how love circulates in neoliberal societies and in the subjective processes of the users, foregrounding the control of populations and the very much lamented “end of love” (Illouz 2019). My study of love supplements the neoliberalist critique of algorithmic love with a posthuman and media theory approach that attends to the material …

In-Work Recovery Among Hybrid Employees: Examining The Relationships Between Stressors, Recovery Experiences, And Strains, Stefanie Larsen

Dissertations, Theses, and Capstone Projects

There has been a drastic increase in the number of hybrid employees (i.e., employees who work remotely for part of a workweek) since the COVID-19 pandemic. While previous research has highlighted some of the benefits and costs of remote work, research on hybrid work is still in its early stages. One area that remains unclear is how hybrid work relates to stressor experiences and in-work recovery from work. The present study examined how levels of specific stressors (i.e., workload, availability pressure) vary depending on whether employees work remotely or in the office, and how the variations of these stressors across …

Protein-Protein Interactions In Cell Cycle Proteins: An In Silico Investigation Of Two Important Players, Andriele Eichner

Dissertations, Theses, and Capstone Projects

The examination of the cell cycle carries significant implications for the biology, health, and overall existence of all living things. These implications span from the development and growth of these organisms to the aging process and cancer, as well as the potential of stem cell therapies to repair diseases and injuries. Numerous proteins of the cell cycle are essential for cellular division and proliferation and are widely conserved over the course of evolution. In this work, we aimed to investigate the molecular processes of protein-protein interactions in cell cycle proteins, centering on two key players: Cdc6 in budding yeast and …

Dancing In The Heart Of The Empire, Talisa Feliciano

Dissertations, Theses, and Capstone Projects

Dancing in the Heart of the Empire is an urban ethnography of public transit space in New York City. The work is based on five years of research on the trains of the Metropolitan Transit Authority’s (MTA) subway system. This work primarily focuses on Black and brown youth dancers who perform on the subways. Combining participant observation, archival research, digital social media research, and interviews, the dissertation identifies dancing as a form of resistance to the racialized structure of the train space and New York City. Public transportation is the heartbeat of the city. It is a contested site of …

Turf War: Interstate Banking And Industry Consolidation, 1965–1998, Erin Cully

Dissertations, Theses, and Capstone Projects

This dissertation examines the advent of interstate banking in America during the second half of the twentieth century. To become the giants they are today, US financial institutions had to overcome, in fits and starts, the political limits on their geographical expansion across municipal, county, state, and national borders—and not always in that order. Faced with new competitors and harsh economic conditions, some bankers set their sights on expanding their markets to stay afloat. Many policymakers and regulators were responsive to this demand, hopeful that it could serve as a catalyst for economic growth. Challenging restrictions on interstate banking meant …

No Ela Without Ella: Understanding The Naming And Crafting Of Gendered Subjectivities In Puerto Rico, Carmín Quijano Seda

Dissertations, Theses, and Capstone Projects

At the beginning of the 20th century, the official metadiscourses about gendered job titles sedimented the idea that names or indexes pointing to women should be interpreted as unskilled, cheap, or even free labor in Puerto Rico (Azize, 1985; Muñiz Mas, 1998; Baerga-Santini, 1999). For this reason, Puerto Rican women organized and fought for equality in work settings. Furthermore, they became more active in politics and the government. Nevertheless, the Estado Libre Asociado (ELA) and local media discourses and interpretations about women’s labor discouraged them from participating in more senior positions (Acevedo Gaud, 2012).

However, this interpretation seemed to have …

Migrant Children And Legislation: Integrating Knowledge About Trauma Into Policy, Yolennys E. Albornoz

Dissertations, Theses, and Capstone Projects

This study seeks to integrate some knowledge about trauma into migration policies in the U.S. regarding children. Migration is not a novel concept; it is a dynamic phenomenon that experiences continuous changes and constantly increases in numbers. Globally, the United States has been the primary destination for foreign migrants for a long time, and most of them are Latinos who cross the U.S. and Mexico border. Here, I explore how children face trauma in their home country, which forces them to migrate. Also, while they migrate and after they have migrated, exposing the three stages of trauma for migrant children. …

Seeing Safety In Red: Expressions Of Interpersonal Gratitude Affects Conservatives’ Political Attitudes In The United States, Kyle M. Anderson

Dissertations, Theses, and Capstone Projects

The current research focuses on how the expression of interpersonal gratitude might affect conservative attitudes, behaviors, and policy support in the United States. This was investigated either through expressions of gratitude or receiving gratitude to an interpersonally close other, as in Studies 1 and 2, or expressing gratitude to an authority figure or equal in one’s life, as in Study 3. Study 1 showed that expressing gratitude, relative to receiving gratitude, reduced support for general conservative ideology. Using serial mediation analyses, Study 2 demonstrated that expressions of gratitude, relative to receiving gratitude, directly reduced perceptions of relational uncertainty, which increased …