Digital Commons Network^™

Structural Basis Of Signal Transduction Within Environmental Sensing Pas Regulated Ser/Thr Kinases, Roksana Azad

Dissertations, Theses, and Capstone Projects

To sense environmental cues, nature has evolved molecular switches that are widely used across life. This process often relies on environmentally controlled PPIs (Protein-Protein Interactions) within a sensory domain that senses various stimuli and alters the functional activities of downstream effectors. This study focused on the superfamily of PAS (Per-ARNT-Sim) environmental sensory domains and their roles in regulating two Ser/Thr Kinases (STKs). PAS domains achieve their regulatory control by internally binding small molecule ligands/cofactors (e.g., O₂ binding to heme …

The Effects Of Isolated Affordances On Preschool Counting Improvement When Using A Digital Coloring App, Katherine Papazian

Dissertations, Theses, and Capstone Projects

Counting is an important preschool math skill that is necessary for building a strong foundation in mathematics. Previous research has demonstrated that guided counting activities can improve counting ability in preschoolers and that drawing on paper while learning can deepen processing, but research has not included digital drawing as a potential means of deepening processing while children count. This study developed a novel touch-screen app, which used a guided coloring activity to encourage effective counting skills and serve as a home numeracy tool that could be employed by all parents, including those with math anxiety. To evaluate the benefits of …

Somos Boricuas Y Estamos Despertando: Decolonial Education, Collective Identity, And The Struggle For Puerto Rican Studies, Ricardo Gabriel

Dissertations, Theses, and Capstone Projects

Student movements have been and continue to be major catalysts for social change. The Puerto Rican student movement at The City University of New York (CUNY) during the late 1960s and early 1970s played a central role in desegregating CUNY—the largest urban university system in the United States—and establishing Black and Puerto Rican studies departments throughout the CUNY system. Student-activists also agitated for participatory democracy and community control of university institutions. Despite the movement’s intellectual contributions and its impact on higher education, it has received little scholarly attention. This study helps fill that gap by exploring the movement’s origins and …

Hypo-Cathexis And Impotence In The Facilitating Environment Of The Anthropocene: Towards Digital Humanities, Brian W. Millen

Dissertations, Theses, and Capstone Projects

This thesis is an attempt to understand why there does not seem to be enough will to take proper action in light of the information we have about the destructive effects of the Anthropocene, in particular: climate change and the destruction of biodiversity. It is an attempt to follow the injunctions of French philosopher Bernard Stiegler to re-examine and re-evaluate knowledge in terms of the primary role of technics in human experience, and to preliminarily situate the digital humanities within such a project. In this paper, I investigate Sigmund Freud's concepts of cathexis, decathexis, and hyper-cathexis as psychic mechanisms whereby …

Development Of Chemical Probes For Two Pro-Metastatic Enzymes: Cysteine Cathepsins And Nek2 Kinase, Ashif I. Bhuiyan

Dissertations, Theses, and Capstone Projects

Proteases, specifically cysteine proteases, are crucial for the survival and growth of living organisms. They hydrolyze proteins and use different mechanisms to function. Cysteine proteases are classified into three types: papain, caspase, and picornaviridae. The papain class, with 11 cysteine cathepsins, regulates essential physiological functions, and abnormal expression is linked to various diseases. Our research aims to develop small molecules that inhibit cathepsins B and L to develop probes for functional proteomics.

The centrosome is critical for proper cell division and is regulated by multiple kinases, including Nek2. Nek2 is highly concentrated at the centrosome in vertebrates and plays a …

Improving Collagen-Mimetic Fibrils To Study Fibrillogenesis And Effects Of Disease-Causing Mutations On Fibrillogenesis, Faizunnahar Dewan

Dissertations, Theses, and Capstone Projects

Collagen, the most abundant protein in the human body, serves as the scaffold of connective tissue and has biomaterial applications to promote wound healing. The need to study collagen further stems from a disease perspective, as mutations in collagen lead to numerous connective tissue diseases. While collagen has been explored extensively at the triple helix level, much remains undiscovered regarding its function at the fibril level due to the lack of an effective collagen model system. Using tandemly repeating “sequence units” that contain sequences from native collagen, our lab has previously developed fibril-forming collagen-mimetic peptides (FCMPs), which provide tools to …

Memory, Violence, And Detours: Strategies Of Resistance To Epidermal Invisibility Within The French Republic, Claudine E. David

Dissertations, Theses, and Capstone Projects

The subjection of black citizens in France and their invisibility in the (post)colonial space has been marked by segregation in peripheral urban zones, with a hardening of policing methods and controls based on racial appearanc. I argue that monumental representation in public space is not neutral but participates in the promotion of a specific ideology. I show thé ellipses in French patrimonial monumental glorification, including the appropriation of the memory of revolutionary heroes such as Louis Delgrès and Toussaint Louverture, concomitant with the occultation of many other black figures. I argue that representation matters, that France must repair this asymmetrical …

Investigating Epistemic Violence In Schools Using Machine Learning (Ai) To Explore The Effects Of Culturally Inclusive Curricula On High School Students’ Racial-Ethnic And Civic Identities, Leylah M. Bighach

Dissertations, Theses, and Capstone Projects

This study investigated the impact of culturally sustaining/inclusive curricula (CSP/CIC) and experiences of racism in school on racial-ethnic identity, racial self-worth, civic efficacy, and activism for African American/Black, Latino(a)(x), Asian, and Indigenous youth. The effect of CIC/CSP on developmental psychological self-concepts and the impact of the public health crises occurring in 2020 on curricula and activism was explored. The effect of CIC/CSP on non-White youth from New York City was captured using an interactive web-based survey (n=155) and quantified using a branch of artificial intelligence called machine learning. Consensus narratives and focus groups (n=20) were used to follow up on …

Settling Into Inequality: Resettled Afghans In The Washington Dc Metro Area, Harry Frey

Dissertations, Theses, and Capstone Projects

Since the Taliban returned to power in Afghanistan in August of 2021, nearly 90,000 Afghans who had fled their country have been resettled in the United States, constituting one of the largest groups of refugee arrivals in the U.S. in recent history. Working from a database I created from the administrative records of a non-profit refugee aid group, I use data and spatial analysis to examine the demographics of Afghans resettled in the DC metro area, the characteristics of the census tracts and counties in which they have been resettled, and their access to public transportation. I find that the …

Redrawing The Contours Of Care: Ethical Commitments And Gendered Politics In The Work Of Government Psychological Counsellors In Sri Lanka, Nadia Augustyniak

Dissertations, Theses, and Capstone Projects

Over the last three decades, Sri Lanka has seen a growing popular interest in psychology as a field of professional practice as well as a steady expansion of mental health services. Historically, this shift has been linked to the impacts of political violence (1971, 1987-1989), civil war (1983-2009) as well as the 2004 Indian Ocean Tsunami, with local and international trauma and humanitarian interventions shaping recovery and the country’s mental health and psychosocial care infrastructure. More recently, however, psychology and mental health have been increasingly decoupled from the discourse of trauma, entering into everyday life and popular culture through the …

Between Two Messiahs: An Ethnography Of Settler-Colonizers In The West Bank, Amir Reicher

Dissertations, Theses, and Capstone Projects

This dissertation is a study of settler-colonialism. Based on fieldwork among Jewish settlers in the West Bank, it analyzes from an anthropological perspective how a settler-colonial process takes place. Officially, since the signing of the Oslo Accords, with few exceptions, Israel ceased to build new settlements in the West Bank. But, on the ground, from the 1990s onwards, the West Bank hinterland was scattered with over 150 illegal outposts, strategically constructed to appropriate as much land as possible. Often established on remote hilltops, the illegal outposts are the central tool today in appropriating Palestinian land, and the “outpost people” who …

The Relationship Between “Black Lives Matter” Movement Protests And Police Arrests In New York City, Chicago, And Los Angeles: An Empirical Analysis, Lukas Louwagie

Dissertations, Theses, and Capstone Projects

The summer of 2020 marked a boiling point of protest and frustration at long-criticized police behavior in the United States. The events that summer revealed the “Black Lives Matter” (BLM) movement as something that could not be ignored and was capable of drawing national support and attention across many dividing lines (Mitchell 2020). Today, it seems evident that the BLM movement has had a substantial impact on modern political discourse—yet its impact on police behavior and reform, the primary target of the movement, is murky. Police departments across the nation are pushing back against calls to defund and reform their …

Recursive Functional Learning In Nonfluent Aphasia, Gerald C. Imaezue

Dissertations, Theses, and Capstone Projects

People with nonfluent aphasia (PWNA) require feedback from an external agent as well self-feedback to facilitate performance of language production tasks. The extent to which PWNA can use self-feedback alone to improve their task performance is unknown. In addition, it is argued that self-feedback may reinforce or minimize performance errors over time. To test whether either is the case, we introduce an original learning mechanism, recursive functional learning, which uses self-feedback loops to optimize recursively multiple subsystems (cognitive and linguistic subsystems) that PWNA engage during task performance. We used this mechanism to underpin a novel automated procedure we developed, recursive …

Learning To Fly While Staying Grounded: How Forcibly Displaced Individuals Develop A Sense Of Belonging In Disempowered Cities, Janina L. Selzer

Dissertations, Theses, and Capstone Projects

Despite a growing interest in belonging, immigration and urban scholarship has yet to develop an empirically grounded, spatially sensitive, and complex theorization of the concept itself. Drawing on a comparative case study of two disempowered cities – Bielefeld, Germany, and Detroit, US, – this dissertation analyzes how and to what extent forcibly displaced Yazidi and Chaldean Iraqis develop a sense of belonging. By triangulating data from semi-structured interviews, ethnographic observations, as well as a discourse analysis of policy documents, the following pages trace how politics of belonging are continuously produced, reproduced, and challenged through a spatially mediated and often contradictory …

Population Genomics, Ecology And Conservation Of Asterias Sea Stars In The North Atlantic, Melenia I. Giakoumis

Dissertations, Theses, and Capstone Projects

Uncovering how species respond to environmental change is a central question in biology (Ehrlén & Morris 2015; Habibullah et al. 2022). It is the key to elucidating the past, understanding the present and predicting the future of species’ population dynamics. This dissertation investigates the influence of environmental change on intertidal species’ distributions and genomics at several timescales, with implications for conservation.

Environmental changes have occurred throughout history, on a geological scale, and have shaped the global patterns of species’ distributions and population sizes. Biologists have long studied how geological history has shaped species distributions (Sanmartín 2012) in both terrestrial (Liu …

Burnout And Depression In Teachers And Members Of Other Occupational Groups: A Systematic Review And Meta-Analyses On Potentially Overlapping Conditions, Gail Swingler

Dissertations, Theses, and Capstone Projects

Burnout has long been recognized as a workplace issue among teachers, and other occupational groups. Burnout has potentially been increasing during the Covid-19 pandemic. Researchers tend to regard burnout as a distinct syndrome comprising emotional exhaustion (EE), depersonalization (DP), and reduced personal accomplishment (rPA). Recent evidence suggests that burnout (as a tripartite syndrome) lacks discriminant validity vis-à-vis depression. The overlap between burnout and depression was examined through two meta-analytic studies.

The first study (K = 13) examined the relationship between burnout and depression in teachers with burnout assessed using the MBI. The findings indicated that exhaustion (EE), and depression …

Birthing, Nursing, And Grieving: An Anthropological Archaeology Of Healing Shrines In North Lebanon, Sarah Mady

Dissertations, Theses, and Capstone Projects

This archaeological study of healing shrines in North Lebanon begins with the story of why scholars have neglected these shrines. It is not essential to identify a gap in the scholarship without understanding why this gap existed in the first place. Healing shrines were often associated with popular religion and women’s superstitions, and to understand their position in the historical landscape of North Lebanon, I begin by laying out the history of archeology in Lebanon. It is imperative for the reader of this study to understand how the discipline of archaeology was founded and practiced and its implications on the …

Artists, Activists, And Therapists Making Meaning Of Collective Violence In Lebanon: A Community-Engaged Participatory Research Study, Nawal Muradwij

Dissertations, Theses, and Capstone Projects

This study collaborated with community-engaged artists, activists, and mental health workers living in Lebanon to explore the community narratives that exist around collective violence in Lebanon. With the support of a community advisory board, in-depth interviews, and focus groups were utilized to understand the associations that participants had with the construct of collective violence as it pertains to communities in Lebanon and their understanding of its impact on collective mental health. The sample of artists, activists, and mental health workers framed collective violence in Lebanon as intergenerational, perpetual, and institutionally and politically entrenched. Cultural concepts that described the impact of …

Sonorous Movement: Cellistic Corporealities In Works By Helmut Lachenmann, Simon Steen-Andersen, And Johan Svensson, John Popham

Dissertations, Theses, and Capstone Projects

In Sonorous Movement: Cellistic Corporealities in Works by Lachenmann, Steen-Andersen, and Svensson, I analyze three compositions that foreground the cellist-body, its physical gestures, and instrumental interactions: Helmut Lachemann’s Pression für einen Cellisten (1969/2010), Simon Steen-Andersen’s Study for String Instrument #3 (2011), and Johan Svensson’s marionette for string instrument, electro-mechanical devices and lights (2018). These works center sound production and the performing body as sites of ontological and creative exploration. Their physical gestures serve multiple sensorial functions, heightening the visual and kinesthetic dimensions of a traditionally aurally oriented practice. For each work, I develop a corresponding analytical method based on …

Examinations Of The Close Relationship Processes And Health Framework Among Adult And Adolescent Sexual Minority Men, Trey Victor Dellucci

Dissertations, Theses, and Capstone Projects

Despite advancements in biomedical preventions for HIV, sexual minority males continue to be disproportionately affected by HIV. Previous research has estimated that up to two thirds of HIV incidence among sexual minority male adults occur between main partners. In the past decade, a growing number of studies and intervention trials have focused on main relationships as a context for HIV. Much of this work has focused on adult relationships and has been grounded in interdependence theory and highlighted the importance of relationship functioning in facilitating the decisions couples make around condom use. Fewer studies, however, have examined the association between …

Colonial Investments: The Global Coordinates Of The English Political Imaginary, 1628–1668, Nathan D. Nikolic

Dissertations, Theses, and Capstone Projects

The main question my dissertation attempts to address is: what role did the expansion of English colonial trades play in the transformation of English society and government between the Petition of Right and the early years of the Restoration (1628-1668)? My thesis is that during this period, colonial expansion rose to the level of a general national interest and that many early seventeenth-century texts index the complexities and tensions of this development. As a small but very organized group of merchants, peers, and MPs mobilized the military and financial technologies of colonization to support Parliament’s war against Charles I, their …

Representaciones Ideológicas Del Lenguaje Entre La Población Mexicana En Nueva York, Maria Del Rocio Carranza Brito

Dissertations, Theses, and Capstone Projects

The purpose of this dissertation is to explore the linguistic ideologies that Mexican migrants bring when migrating and reproduce in their daily interactions with other Spanish and English speakers, as well as the representations of the language presented in their linguistic behaviors. This work presents an intersectional analysis where the factors of gender, migratory status, education, and work are determining factors in the adoption, maintenance, and reproduction of language ideologies, which affect the linguistic decisions of the speakers in their use of Spanish, learning of English and the support of bilingualism. Based on the stereotypical idea of Spanish as the …

Flamboyant Abundance: Performing Queer Maximalism, 1960–1990, Jack Owen Crawford

Dissertations, Theses, and Capstone Projects

This dissertation theorizes “queer maximalism” as an aesthetic of unmitigated flamboyance and voracious drag that appears in a constellation of performance-based artistic practices in the postwar United States. Queer maximalism brings together a historically grounded group of performers primarily based in New York City who have been variously described as theatrical, baroque, and Ridiculous and repositions them within an art-historical frame. Identifying drag and pastiche as central to queer maximalism, I show how artists salvage, assemble, and re-signify pop-cultural imagery, inflecting it with camp in order to fashion intimate community and openly flout societal norms of gender, race, and sexuality. …

Drug Repurposing Using Gene Expression Data Mining, Yue Qiu

Dissertations, Theses, and Capstone Projects

The conventional drug discovery process that employs the "one disease, one target, one drug'' paradigm is expensive, time-consuming, and has a high rate of failure for multi-genic complex diseases. An alternative approach to drug discovery is to repurpose an existing drug that has been used to treat some medical conditions. Drug repurposing is considered a promising method due to its accelerated the process of drug discovery and lower overall cost and risk.

Drug-perturbed gene expression profiles are powerful phenotype readouts of biological systems, and they have been widely used in drug repurposing studies. However, the existing drug-perturbed gene expression datasets …

Broadcasting La Presencia Latina: Tracing Identities Across Fields Of Interaction In Rural Minnesota, Anthony J. Harb

Dissertations, Theses, and Capstone Projects

This dissertation project traces the concerted efforts of an emergent Latinx immigrant community in Westplain, Minnesota to construct and assert their individual and collective identities within the public sphere through a range of multimodal and face-to-face communicative resources. I address enduring questions within the fields of linguistic anthropology, language education, and Latinx (media) studies through a multi-sited ethnography centered around three focal field sites: (1) a Spanish-language community radio program I call La Gran Comunidad Latina (LGCL); (2) a college-level civic engagement Spanish conversation course titled Noticias Comunitarias (NC) designed and taught in partnership with LGCL; and (3) an antiracist …

Illness Intrusiveness And Psychosocial Adjustment Among Older Adults With Multimorbidity, Irina Mindlis

Dissertations, Theses, and Capstone Projects

Given the high prevalence of multimorbidity (MM) among older adults and the exponential growth of the older adult U.S. population, identifying factors that can lessen depressive symptoms and improve quality of life (QOL) in this population is timely and important. While it is well established that MM is associated with greater depressive symptoms and poorer QOL (Li et al., 2016; Makovski et al., 2019; Marengoni et al., 2011; Read et al., 2017), the mechanisms underlying these relationships remain understudied. The illness intrusiveness model (Devins et al., 1984) proposes that stressors posed by diseases (disease-related factors) and their treatments (treatment-related factors) …

Abuse Victimization And Impulsivity In Incarcerated Males: Examining The Roles Of Affective Instability And Trauma Symptoms, Jacqueline K. Douglas

Dissertations, Theses, and Capstone Projects

Incarcerated individuals with a history of physical and/or sexual abuse have been found to exhibit increased levels of impulsivity compared to those with no abuse history (Carli et al., 2014; Davis et al., 2017; Sergentanis et al., 2014). Given that impulsivity is a risk factor for criminal delinquency (Carroll et al., 2006; Kamaluddin et al., 2015; Zimmerman, 2010), it is important to gain a thorough understanding of psychological factors that may contribute to higher levels of impulsivity in incarcerated populations. The present study examined the mechanisms underlying the relationship of physical and/or sexual abuse history to impulsivity in a sample …

The Role Of Intersectional Stigma And Social Anxiety In Black, Latino, And Multiracial Young Sexual Minority Men, Jorge L. Cienfuegos Szalay

Dissertations, Theses, and Capstone Projects

Black, Latino, and Multiracial YSMM are at disproportionate risk of acquiring HIV despite engaging in similar or less HIV risk behaviors when compared to their White YSMM counterparts. While over two decades of research have highlighted minority stress theory as a potential explanation as to why this disparity exists, increased efforts are being made to infuse this body of work with an intersectional framework. Intersectionality posits that individuals with multiple, interlocking social identities that are continuously affected and impacted by various forms of marginalization and stigmatization are at an increased risk of negative psychological and physical health outcomes. Current data …

Variations In Family Child Care: Providers' Experiences Crafting Spaces In-Between School And Home, Eleanor Luken

Dissertations, Theses, and Capstone Projects

Family child care, which takes place in the caregiver’s own home, is one of the most common arrangements for American working parents, yet it remains low paid and undervalued in the ecosystem of early childhood care and education (Uttal and Tuominen, 1999). Little is known about how family child care providers organize space within their homes and the repercussions the location of care has on their daily practices with children, relationships with family members, and design of their homes. Even less is known about the strategies used by providers operating in dense, urban neighborhoods with high housing costs. This investigation …

Singlet Oxygen-Mediated Conformational Flexibility, Antioxidant, And Isomerization Studies In Chemistry And Biochemistry, Oliver Turque

Dissertations, Theses, and Capstone Projects

Three chapters are included in this dissertation, each of which describes non-oxidative reactions, with peroxy intermediates formed between singlet oxygen (¹O₂) and substrate. (1) Novel discoveries related to the intermediate formed by ¹O₂ and dimethyl disulfane are explored. (2) A new mechanism is proposed, wherein the dihedral angle CS–SC (θ) determines the pro- or antioxidant activity of an organic disulfide. (3) A review of ¹O₂'s ability to facilitate the geometric isomerization of alkenes and polyenes is presented in Chapter 3.

Chapter 1 investigates the role of singlet oxygen potentially …