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Molecular Expression Of Neuroprotective And Neurodestructive Signaling Systems Following Axotomy-Induced Target Disconnection: Relevance To Als, Melissa Marie Haulcomb

Dissertations

Amyotrophic Lateral Sclerosis (ALS) is the most common adult motoneuron (MN) degenerative disease. Discovery of a portion of familial cases with a mutation in the gene superoxide dismutase 1 (SOD1) gene led to the development of a transgenic mouse model. Pre-symptomatic SOD1 mice show no symptoms well into adulthood, however once symptom onset has occurred they display pathological hallmarks of ALS. The initial pathological event is loss of neuromuscular junctions in the lower limbs and therefore the die-back theory of ALS, suggests disconnection from the target musculature leads to MN degeneration. Our lab utilizes a peripheral nerve injury model to …

Pax Ecclesia: Globalization And Catholic Literary Modernism, Christopher Wachal

Dissertations

The transnational turn in literary studies has brought new rubrics and critical vocabularies to the study of cultures experiencing the destabilizing effects of globalization. It gives special attention to the ways cultural forms, including literature, must be reformulated in the absence of the coherence of the nation-state. Often unremarked upon, however, is the role of religion in providing other channels of affinity around which to cohere. Many writers in the 20th century respond to the shocks of globalizing modernity by writing in light of particular faith traditions, especially the aesthetic strategies and thematic concerns that characterize the Catholic literary tradition. …

A Salutogenic Framework To Understand Disparity In Breast Cancer Screening Behavior In African American Women, Regina Conway-Phillips

Dissertations

African American women (AAW) have the highest breast cancer mortality rate than any other racial or ethnic group. Limited access to care reduces mammography screening for AAW. Despite barriers, some AAW engage in breast cancer screening (BCS) behaviors like mammography. The salutogenic theory of health focuses on positive health behaviors and offers a framework to understand personal factors which allow some AAW to overcome adversity and engage in BCS. Sense of coherence (SOC) is central to salutogenic theory. Individuals with greater SOC utilize available resources to attain optimal health. This study: 1) Evaluated the contribution of SOC, social support and …

Global Distributive Justice After Rawls: A Modified Poggean Argument For How We Harm The World's Poorest, Mark Chakoian

Dissertations

This work presents an analysis of Thomas Pogge's approach to the problem of world poverty as presented in World Poverty and Human Rights. It begins by situating the project of Pogge relative to the work of his predecessor John Rawls. It then moves on to compare Pogge's negative-duty approach to more common positive-duty approaches by discussing the relative merits and weaknesses of the approach of Peter Singer to the problem of poverty. The remaining chapters give an in-depth analysis of Pogge's argument itself. Although there are significant holes and inconsistencies in Pogge's approach, a reformulated argument that preserves his original …

Thinking Through The Phenomenon Of Trust: A Philosophical Investigation, Jeffrey M. Courtright

Dissertations

Jeffrey M. Courtright

THINKING THROUGH THE PHENOMENON OF TRUST: A PHILOSOPHICAL INVESTIGATION

The phenomenon of trust is historically underrepresented as a topic of serious investigation in Western philosophy. This dissertation investigates the integral role that trust plays in enabling and sustaining meaning and significance in human existence. This thesis is substantiated in the following ways.

First, I explicate various senses and ways of thinking about trust in the work of two historically important philosophers, Plato and Nietzsche. I show that Socrates, in Plato's dialogue Phaedo, articulates the feeling of being entrusted with life, a feeling that one experiences as a …

Images Of God, Imago Dei And God's Relationship With Humanity Through The Image Of Mary's Breast Milk: A Focus Upon Sor María Anna Águeda De San Ignacio (1695-1756), Neomi Dolores Deanda

Dissertations

This dissertation presents an original contribution to the academic field of Theology, specifically Constructive Theology, because it begins the retrieval work of a woman's voice from seventeenth and eighteenth century Mexico, an entire area of historical and theological thought which has been globally under-explored. Analysis of María Anna Águeda de San Ignacio's eighteenth century original publications give a glimpse into this woman's official authority during her time, which also presents a historical woman's voice who has held ecclesial authority.

This project engages María Anna Águeda de San Ignacio's work to draw theological insights and further expand understandings about notions of …

Globalizing Kenyan Culture: Jua Kali & The Transformation Of Contemporary Kenyan Art: 1960-2010, Margaretta H. Swigert

Dissertations

In an age of globalization, when as a result of enhanced telecommunication and global media, the world's population is more interconnected than ever, the public at large still tends to associate Africa with poverty, disease and political instability. Yet keen observers of the social landscape have observed that despite Africa's legacy of woes, cultural productivity in the region is on the rise, leading scholars to refer to the phenomenon as an African Renaissance. This is particularly the case in Kenya where a contemporary art movement is flourishing through both local and global art networks. But the question remains: how in …

Introducing The Common Good Index And A Common Good Immigration Ethic, Ana Bedard

Dissertations

The U.S. and Mexican bishops, in their influential pastoral letter Strangers No Longer, frame immigration ethics through the lens of solidarity with the immigrant. This frame leads them to erroneously interpret the preferential option for the poor and ignore potential harm to poor U.S. citizens caused by recent undocumented immigration from Mexico and other countries. A better framework to immigration ethics is a specified common good approach, which is created in this dissertation. This approach uses the definition of the common good found in Catholic social thought and concretizes it through using a theological anthropology based in Martha Nussbaum's human …

The Impact Of Treating Major Depression During Pregnancy On The Postpartum Phase, Jamie Kent

Dissertations

Major depression during pregnancy is a risk factor for postpartum depression (PPD). Medically acceptable treatments for depression during pregnancy and postpartum are limited and many women are turning to complementary and alternative treatments. The current project examined whether treatment of major depression during pregnancy reduced the risk for PPD and explored predictors of PPD in this high-risk sample. One hundred twenty women were clinically assessed using the Hamilton Rating Scale for Depression (HRSD17), the Beck Depression Inventory (BDI-II), and the Structured Clinical Interview for DSM-IV (SCID) at ten weeks, six months, and nine months postpartum following random assignment to one …

Professional And Personal Lives Of Psychologists: Spillover, Family Functioning, And Life Satsiafction, Pedja Stevanovic

Dissertations

Two-wave, longitudinal data from a national, web-based survey of doctoral psychologists was used to examine work life, spillover, family, and personal lives. A measure of spillover, Stressors and Enhancers for Psychologists, was also evaluated. Confirmatory factor analysis indicated two negatively correlated dimensions of work spillover: positive spillover termed family enhancers and negative spillover termed family stressors. This measure was significantly related to a widely used, more general measure of positive and negative spillover and demonstrated high temporal stability. Respondents reported a significantly higher incidence of family enhancers than family stressors at both data collection points. Consistent with previous research, the …

Moving To The Level Of Representation To Explain Variations In Family Child Care Provider Sensitivity And The Effectiveness Of Child-Related Training, Diana Davidson Schaack

Dissertations

Many young children in the United States spend a substantial amount of time in the care of family child care providers. Previous research has found that when providers are sensitive and responsive to children's needs, children are more likely to develop secure attachment relationships with their providers, which, in turn, have been linked to many developmental benefits for young children. Unfortunately, it appears that many children do not experience the levels of caregiving sensitivity that are necessary to develop secure attachment relationships with their providers and that increased child-related training is not always effective at improving provider caregiving behaviors.

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Neighborhood Sum Parameters On Graphs, Frank Allen O'Neal

Dissertations

No abstract provided.

Bit Error Rate Locked Loops Using Log-Likelihood Error Correction Decoders, Eric Rives

Dissertations

No abstract provided.

Thermal Diffusivity Determination In Sn-Based Lead-Free Solder Alloys, Manijeh Mohammad Alipour

Dissertations

No abstract provided.

The Catalytic Mechanism Of Archaeal Inorganic Pyrophosphatase Revealed By X-Ray And Neutron Crystallography, Ronny C. Hughes

Dissertations

No abstract provided.

A Proposed New Model To Understand Lean Implementation Using Employee Perception, Sushil Kumar Shetty

Dissertations

No abstract provided.

Optical Monitoring Of Surface Anchoring Changes For Nematic Liquid Crystal Based Chemical And Biological Sensors, Yang Zou

Dissertations

No abstract provided.

Designing A Middle School Gifted Education Program Of Excellence Using Current Gifted Programming Models, Samantha Ann Miller

Dissertations

In 2004, the National Association for Gifted Children and the National Middle School Association collaborated to create a joint position statement supporting the educational needs of all middle school students, including those of high potential and ability. Since the creation of this position statement, research demonstrates that little has been done to further the understanding and development of middle school gifted adolescents and corresponding educational programming that meets the gifted adolescents’ needs. This study sought to provide clarity concerning the organization of middle school gifted programming and the components that contribute to the excellence of programs according to the perceptions …

The Relationship Between Caring School Community Program Implementation And Elementary Student Achievement, Michelle R. Wilkerson

Dissertations

This program evaluation of Caring School Community was conducted by two educators who studied the implementation of this character education program in an elementary school. In an effort to foster a culture of respect and kindness, where students, staff, and parents are treated as valued, contributing members of the school community, an elementary school implemented a character education program called Caring School Community. The purpose of this study was to evaluate the success of the implementation of Caring School Community and its possible impact on student achievement. The evaluation of this program involved observing classroom instruction to track student engagement, …

Daily Practices Elementary Principals Utilize To Increase Student Readingachievement: A Case Study Of Successful Michigan Elementary Schools, Susan L. Johnson

Dissertations

This case study examined three K-5 schools, one 3-5 school, and two K-2 Analysis of the data provided six dominant themes related to the research questions: Behavior/Positive Behavior Support, Visibility, Professional Development, Team/Distributed Leadership, Data, and Deliberate/Focused. The dominant themes were cross tabbed with the theoretical frameworks from Marzano et al. (2005) and Fullan (2008a). Connections were made to both Marzano et al.'s Seven Responsibilities of the School Leader for Second-order Change and 21 Responsibilities of the School Leader as well as to four of Fullan's Six Secrets of Change. This study supports previous research and adds to the literature …

Spiritual Capital: The Relationship With Civic Engagement Among Faith-Based Leaders, Sylvia W. Burgess

Dissertations

The current status of America in relationship to civic engagement is one of steady decline. The available research examines the decline from the viewpoint of the role religion plays in engagement, the role of volunteerism, and voting, social networking, and memberships. The purpose of this study was to explore the relationship between spiritual capital, civic participation, and civic engagement. An in depth analysis of relationship between spiritual capital and types and levels of civic engagement was investigated. The research sample included faith-based leaders from five churches in North Carolina and Virginia who were identified by the senior pastors as leaders …

Using Expectation Methods To Estimate A Discrete Choice Model When Individual Choices Are Not Observable: Methodology And Applications To Tillage Choice, Tara R. Wade

Dissertations

This study presents an alternative method of empirical estimation of a logit model that uses the full information on the attributes of agents and only aggregate measures of agents' choices in an application to the estimation of the costs of the adoption of conservation tillage by Iowa farmers. The methodology treats the aggregated data as an expected value-the group average of individual probabilities of choosing conservation tillage subject to measurement error. The study then adapts the new methodology to the distinctive case where the researcher not only has the group expected value but also knows the magnitude of the within …

Development Of Energy Absorbing Laminated Fiberglass Composites Using Electrospun Glass Nanofibers, Evan Kimbro

Dissertations

The ability to predict failure of composite laminates due to delaminations is critical because of its subsurface nature. Traditional strengthening methods such as stitching and Z-pinning, while improving interlaminar properties in woven composites, lead to a reduction of the in-plane properties. Electrospun non-woven sheets of nanofibrous mat applied at interfacial regions offer an option to traditional treatments. Applications where protrusion energy must be dissipated completely would benefit the most from the use of the electrospinning treatment. Examples are bullet proof vests and vehicle armor. Penetration of a projectile through a composite material may be avoided by creating more energy absorbent …

Examination Of The Transformational Life Experiences Of Malcolm X And Their Impact On His Leadership, Beliefs, And Leadership Practices, Brenda Dobbins Barber

Dissertations

The purpose of this research was to examine the life experiences of Malcolm X that led to his beliefs, practices, and transformation as a leader. This study utilized qualitative historical social science research methods that included document analysis, article review, and analysis of materials obtained from web sites. Archival data analyzed included electronic documents, web sites, books, letters, as well as first hand quotes from Malcolm's own writings, lectures, speeches, and first hand reports from wife Betty Shabazz, his children, Alex Haley, and other sources related to Malcolm's life history. The study’s objective was to identify and examine life changing …

Role Of Notch Signaling In T Cell Polarization, Shilpa Keerthivasan

Dissertations

The differentiation of CD4+ T cells to different effector lineages in response to pathogenic stimuli is the core of the adaptive immune system. One of the effector subsets recently discovered is Thelper 17 (Th17) and it plays a predominant role in autoimmune diseases and inflammatory disorders.

In my thesis, I aimed to study the role of Notch cell surface receptors in Th17 differentiation. Using in vitro Th17 differentiation assays of human naïve CD4+ T cells, I have shown that Notch signaling, particularly Notch1, plays a crucial role in Th17 polarization. By using pharmacological inhibitors and specific knockdown of Notch1, I …

The Impact Of Using Formative Assessment Attributes In Daily Instruction On Student Affect, Joshua William Ruland

Dissertations

The main focus of the research was to determine if the systematic use of formative assessment attributes had an impact on two affective variables--Academic Efficacy and Eagerness to Learn. Both the control and experimental students' affect was measured using a pre and post test administration of the Student Affect Inventory created by Popham and Stiggins (2008) in conjunction with the CCSSO. The post administration results of the experimental and control group were compared to determine if the systematic use of formative assessment attributes had a statistically significant impact on student affect. In addition, the pre and post test data of …

Understanding The Career Paths And Experiences Of Division I-A Athletic Directors: A Phenomenological Study, Harold Thomas Swift

Dissertations

The focus of this study was to understand the career paths and experiences of Division I-A Athletic Directors. There are only 120 of these coveted positions in the country. The limited research on how to obtain this position led to this investigation.

This research examined the career paths of 10 Division I-A ADs male (five African American and five White) and their experiences reaching their position. A qualitative phenomenological approach was used as the methodology. One-on-one phone interviews were conducted using open-ended interview questions that elicited information from each participant. The Social Cognitive Career Theory and Critical Race Theory were …

Emergent Technology And The Millennial Generation: Examining The Perceptions Of Students And Implications For Instruction In Higher Education, Karen Martin-Jones

Dissertations

The objective of this research was to determine students' perception of technology in higher education. The study participants were recruited from two institutions of higher learning: a small private women's historically black college (School A) consisting of about 740 students and a large public historically black university (School B) consisting of about 10,000 students, both located in a single mid-sized metropolitan area in the southeastern United States. . The analysis of the data revealed that there was a significant difference in the personal [t(384) = 6.952, p = 0] and educational [t(326) = 7.470, p = 0] use of technology …

Integration Of Cognitive And Physical Factors To Model Human Performance In Fluid Power Systems, Khaliah K. Hughes

Dissertations

Fluid power technology is constantly evolving as a result of the interaction between the human and the system. Systems such as the hydraulic excavator utilize this technology in order to deliver safe, efficient, and effective performance. However, traditional research has placed much emphasis on technical performance rather than on human components. Imbalances of this nature demonstrate inadequate understanding, lack of knowledge, and limited research on the factors affecting performance. This research aims to address these shortcomings by using an integrated approach to better model human performance in fluid power systems. Through the development of an integrative framework considering cognitive and …

Mentoring As A Professional Development Tool In Preparing The Next Generation Of Leaders In The North Carolina Community College System, Manuel C. Dudley

Dissertations

The North Carolina community college is approaching 50 years of existence in 2013. It is a community college system that is respected both nationally and internationally. The economic downturn of the United States has created a period of record enrollment in the community college, as individuals seek upgrades in training, work skills, and educational attainment. This period of record enrollment is not without challenges. Budgetary constraints, a consumer demand for easier access to classes through online and distance learning, and an increase in the racial, ethnic, and cultural diversity of the student population has created a proverbial perfect storm. Many …