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Heat Shock Factor 1 Signaling: A Novel Pathway Implicated In Rett Syndrome Pathophysiology, Sonia Gonzalez

Dissertations

Rett syndrome (RTT) is a severe neurodevelopmental disorder that is associated with loss-of-function mutations in the methyl-CPG binding protein 2 (MECP2) gene. There are limited therapeutic options to address the wide range of social, cognitive, motor, and respiratory symptoms that patients experience throughout their lifetime. To identify novel therapeutic targets, we leveraged a rare form of RTT known as MeCP2-mutation-negative or atypical RTT. Traditionally, RTT is first diagnosed clinically and then confirmed through the identification of mutations in the MECP2 gene. However, ~5% of RTT patients are found to be MeCP2-mutation-negative (atypical), despite sharing overlapping symptomology with typical RTT. We …

Mllt1 Is Required To Maintain B-Lymphopoiesis, Janani Prakash

Dissertations

MLLT1 (also named ENL) is an epigenetic reader protein that binds to crotonylated or acetylated lysine residues of histone 3 through its N-terminal YEATS domain. Positive and negative regulatory complexes compete for binding to C-terminal MLLT1, and promote transcription elongation (SEC, Super elongation complex; DOT1L) or transcriptional repression (PRC1, Polycomb repressive complex 1). MLLT1 was initially identified as a chromosomal translocation partner to MLL(KMT2A) in a subset of MLL-rearranged leukemias. MLL-ENL fusion protein causes both lymphoid (predominantly B-ALL) and mixed lineage leukemias. MLLT1 has been implicated in leukemic stem cell survival in MLL-rearranged cell lines but its role in normal …

Underlying Mechanisms In The Relationship Between Ptsd And Irritable Bowel Syndrome, Jillian B. Heymann

Dissertations

Current bodies of knowledge support the relationships between posttraumatic stress disorder (PTSD) and irritable bowel syndrome (IBS), pain catastrophizing and PTSD, and pain catastrophizing and IBS. However, much less is known regarding how pain catastrophizing influences the relationship between PTSD and IBS. Additionally, while correlations between some demographic and trauma-related symptomatology have been elucidated in the relationship between PTSD and IBS, their impact as potential moderators on the relationship between PTSD and IBS has yet to be fully examined. Examining a student sample from a large midwestern university, the present study aimed to investigate the potential mediating and moderating roles …

Elementary Students' Science Attitudes And Teachers' Implementation Of The Ngss Science Practices: A Mixed Methods Study, Michelle Laborn

Dissertations

It has been recorded in the literature that student science interest drops as students enter and transition to middle and high school. This dissertation takes up the areas of student science interest and the teaching of the science practices in the context of elementary education. This study seeks to understand student science interest in elementary students in the years before entering middle school where a drop of interest is frequently reported. It is hypothesized that an increased use or implementation of the NGSS science practices by classroom teachers would generate higher science interest in elementary students. In a framework of …

Pedagogical Possibilities Toward Positive Embodiment: Applying The Developmental Theory Of Embodiment To Educational Contexts, Elena Buis

Dissertations

Young adolescents, particularly girls, often experience uncomfortable and negative relationships with their bodies, contributing to negative physical, mental, and emotional outcomes. Although educators have implemented interventions to address this issue, those grounded in positive embodiment remain underexplored. Specifically, the Developmental Theory of Embodiment (DTE), a prominent framework in eating disorder and body image research, has not been integrated into educational research or practice. This dissertation explores the integration of DTE into educational theory, practice, and pedagogy across three complementary articles and examines the teaching and learning of Be Body Positive (BBP), a positive embodiment intervention, with a fifth grade Girl …

From Stranger To Self: The Role Of Familiarity In Modulating The N170 And N250 Erp Components, Tabish Gul

Dissertations

This study investigated how varying levels of face familiarity modulate the N170 and N250 event-related potential (ERP) components, two neural markers of face perception and recognition. While the N250 is widely considered familiarity-sensitive, the N170 has traditionally been linked to the structural encoding stage of face perception. However, recent research suggests that face familiarity may also influence N170 amplitude and latency. While most previous studies have compared up to three familiarity levels, the present study examined five levels of familiarity: own face, friend’s face, famous face, experimentally familiar face, and unfamiliar face. Twenty-six participants viewed face images while completing a …

Secondary Teachers’ Perceptions On The Wida Framework To Support Academic Literacy In Multilingual Learners, Laura G. Faris

Dissertations

The purpose of this study was to determine teachers’ perceptions of benefits and barriers to using the WIDA Framework to support academic literacy in multilingual learners (MLs).  Content-area teachers of MLs who continue to learn English are teaching academic literacy through complex linguistic structures for students to both comprehend and produce informative textual structures which occur in secondary textual reading and written assessments in the literature and historical content areas. Qualitative methods including reflective journal entries, semi-structured teacher interviews, and classroom observations were used to collect data on teachers’ perceptions of the effectiveness of using the WIDA Framework to better …

From Structure To Support: An Integrative Model Of Leadership, Emotional Exhaustion, Role Clarity, And Daoist Moderation, Aradhna Mohan

Dissertations

Rooted in the understanding that effective leadership significantly influences organizational outcomes, this study examines process-oriented relationships between leader initiating structure and subordinate outcomes. Specifically, it extends the leadership literature by focusing on the cognitive resources underlying initiating structure behaviors, such as role-related clarity, that may enhance positive subordinate outcomes and mitigate negative ones. The study also incorporates an underexamined Eastern leadership style, Daoist Water-Like Leadership, and explores its associations with leader initiating structure and consideration. Guided by the Job Demands-Resources (JD-R) model, this research assesses the effects of initiating structure and Daoist leadership on emotional exhaustion, examines the relationship between …

The Effects Of Fluency Building On Undergraduate Student Performance, Lauren B. Shibley

Dissertations

Online learning has become integral to higher education, with enrollment steadily increasing over the past decade and accelerating during the COVID-19 pandemic. Research highlights the importance of flexibility, learner autonomy, and self-regulated learning skills in this environment, with studies demonstrating that strategies such as mastery-based, self-paced instruction, fluency training, and timely feedback support student engagement and academic success. Early work adapting personalized instruction for online use (Pear & Crone-Todd, 1999) and subsequent studies on fluency practice (Quigley et al., 2018; Urbina et al., 2019) emphasize how these supports can improve concept retention. Despite these advances, more quantitative research is needed …

Generations At Work: Examining Differences In The Nonprofit Sector, Cory J. Bergeron

Dissertations

This non-experimental quantitative dissertation examined generational differences among non-management employees in the United States nonprofit sector, where multiple generational cohorts work side by side. The problem addressed is that nonprofit leaders’ limited understanding of how distinct generational experiences shape employees’ work-related attitudes and preferences can contribute to conflict, reduced engagement, and costly turnover in already resource-constrained organizations. Grounded in Mannheim’s generational theory and Becker’s human capital theory, the study conceptualized generational cohorts as groups whose shared formative experiences influence what they value in their work context and how those values translate into human capital that affects organizational outcomes.

Using a …

Lyapunov-Krasovskii Based Approach To Time-Delay Systems: Computational Efficiency And Feedback Control, Huan Phan

Dissertations

Time-delay systems arise naturally in many engineering applications due to sensing,actuation, communication, and computation delays. The presence of delays has a significant influence on system performance both positively and negatively. Although Lyapunov--Krasovskii functional (LKF) methods provide a systematic framework for stability analysis and controller synthesis, their implementation often suffers from high computational complexity, particularly for large-scale systems and systems involving multiple feedback channels. This dissertation addresses both computational efficiency and feedback control for linear time-delay systems.The first part of this dissertation develops a decomposition-based approach to reduce the computationalburden of stability analysis. By exploiting structured invariant subspaces associated with the …

Intelligent Surveillance For Weapon Threat Detection: Transformer-Based Detection And Segmentation Using Thermal And Rgb Imagery, Akhila Kambhatla

Dissertations

Proactive public-safety surveillance requires deep learning systems that can detect and segment weapons reliably under real-world conditions. This research develops and evaluates a progressive, multi-phase pipeline that moves (i) from RGB object detection to pixel-level semantic segmentation and (ii) from visible-spectrum cameras to thermal imagery to improve robustness under low-light, clutter, and occlusion. Early phases establish strong detection baselines using one-stage and two-stage detectors (YOLOv5 and Faster R-CNN) for multi-class weapon localization, followed by practical optimization through pruning and ensembling to reduce false positives and computational overhead while maintaining real-time feasibility. Building on the limitations of bounding-box localization, the methodology …

The Phylogenetic And Biogeographic History Of Cranes (Gruidae), Phillip Conrad Williams

Dissertations

Cranes (Gruidae) are a globally distributed clade of large, wetland-associated birds. Prior phylogenetic analyses have shown there to be two major subfamilies, Balearicinae and Gruinae, and five consistently recovered clades within Gruinae. However, the relationships among those five clades has remained contentious. In addition, little has been done to reconstruct the biogeographic history of cranes. To that end, I first inferred phylogeny using a large, nuclear dataset sampled from all 15 extant crane species and two outgroup species. The phylogeny mostly agreed with previous analysis using whole mitochondrial genomes but differed in that the Anthropoides species group formed a sister …

A Phenomenological Study Of Teachers Who Use Oral Reading To Foster Student Reading Fluency And Engagement, Donyetta Grimes

Dissertations

The National Reading Panel (2000) recommends oral reading instruction as a means to improve overall reading fluency and reading comprehension. Oral reading fluency is a necessary foundational skill, and students who have not mastered it by the end of third grade, when students transition from learning to read to reading to learn, become struggling adolescent readers (Ming, 2018). Furthermore, there is a lack of research on reading fluency past the primary grades (Makebo et al., 2022). Additionally, research gaps exist when considering teachers’ actual practices during reading instruction (O’Sullivan et al., 2009). This gap is particularly concerning considering that teachers …

Science For All: Utilizing Native And Everyday Language To Increase Academic Performance And Student Engagement For High School English Language Learners, Lashanda K. Whitworth

Dissertations

In public high schools across the U.S. high stakes assessments are seen as a lever to facilitate high-quality education and to gauge student learning. English Language Learners are mainstreamed into content classes and despite having low English proficiency scores are expected to perform as well as English first students and are required to take district and state mandated biology assessments. At the research site, ELLs comprise 25% of students and consistently score below the other subgroups in biology. This quasi-experimental study tested whether using disaggregate instructional strategies—incorporating ELLs’ native and everyday language—increases learning gains, academic growth, and engagement in a …

Federated Neuromorphic Intelligence: Advancing Robustness, Efficiency, And Continual Adaptation In Edge Environments, Manh V. Nguyen

Dissertations

This dissertation investigates how spiking neural networks (SNNs) can improve federated edge intelligence by advancing three interconnected goals: communication efficiency, adversarial robustness, and continual adaptation. As edge computing deployments expand across Internet of Things (IoT), sensing, and privacy-sensitive applications, conventional federated learning approaches built around artificial neural networks (ANNs) face growing limitations in power consumption, bandwidth demand, and resilience to real-world uncertainty. SNNs offer an alternative computational paradigm based on event-driven, sparse, and temporally structured processing that is naturally suited to constrained edge environments. However, their behavior in practical federated settings remains insufficiently understood.

To address this gap, this dissertation …

First-Year Seminar’S Influence On Thriving In First-Year Students, Chelsea Miller

Dissertations

First-year students struggle with attrition. Prevention of attrition has various interventions on such first-year seminars. Typically, these interventions use academic outcomes to measure effectiveness. Prior research supports that students enrolled in first-year seminar benefit academically from the intervention. However, these outcomes do not fully capture all the possible benefits of this intervention. This leaves room for research on other possible outcomes. Thriving as a construct incorporates both academic and social elements. Thriving is a possible outcome that could capture the benefits of first-year seminars. This study examined how much of the variance in thriving was explained by participation in first-year …

The Paradox Of Twice-Exceptional Teacher Experience: A Narrative And Visual Inquiry, Michael Danielle Bell

Dissertations

Twice-exceptional (2e) individuals, those with high cognitive ability and concurrent disabilities, have been the primary focus in K-12 research, yet they largely disappeared from research as adults. This narrative inquiry examined the lived experiences of three 2e educators navigating the public school system. Grounded in the Neurodiversity Paradigm and the Social Model of Disability, the study utilized semi-structured interviews and photo elicitation to externalize the sensory and cognitive realities of 2e educators through an affirmative, strengths-based lens. Narrative analysis revealed a central synthesis of the paradox of 2e educator experiences that highlighted participants’ neurodivergent traits as simultaneously their greatest professional …

Exploring Predictors Of First-Time National Council Licensure Exam For Registered Nurses Next Generation Success In Bachelor Of Science In Nursing Program To Determine The Need For Remediation, Ashton Clarkson

Dissertations

Passing the National Council Licensure Exam for Registered Nurses (NCLEX-RN) on the first attempt is crucial not only for nursing students but also for nursing programs and employers. Nursing programs’ reputations rest on their first-time NCLEX pass rates for incoming students and for national accreditation (Accreditation Commission for Education in Nursing, 2023; Commission on Collegiate Nursing Education, 2024; Commission for Nursing Education Accreditation, 2021). Also, the United States is experiencing a nursing shortage that could be alleviated by more nurses passing the NCLEX-RN on the first try. This quantitative study aimed to determine whether there is predictive ability between the …

Reframing Health: A Phenomenological Inquiry Into The Lived Experiences Of Weight- Inclusive Healthcare Providers, Hannah Brass

Dissertations

The purpose of this phenomenological study was to understand the unique lived experiences of healthcare professionals who practiced from a weight-inclusive lens. This study was guided by the following research questions:

Q1 What is the unique lived experience of a healthcare provider practicing from a weight-inclusive lens?

Q2 What are the significant experiences that have influenced the development of weight-inclusive providers’ attitudes (i.e., thoughts, feelings, and behaviors)?

Data from these findings were analyzed using Giorgi’s (2009) descriptive phenomenological method to discover rich descriptions and themes of weight-inclusive healthcare practitioners' experiences. The study explored the significant experiences and supports that influenced …

Establishment Of A Hek293t Cell Model System To Investigate Direct Intracellular Interactions Between Amyloid-Β (Aβ) And The Nlrp3 Inflammasome, Cristina Sinobas Pereira

Dissertations

Alzheimer’s disease (AD) is a progressive neurodegenerative disorder and the leading cause of dementia worldwide. While Amyloid-β (Aβ) aggregation is a defining pathological feature, increasing evidence highlights chronic neuroinflammation as a critical contributor to disease progression. Soluble Aβ assemblies can act as damage associated molecular patterns (DAMPs) including activation of the NLRP3 inflammasome, which links amyloid pathology to sustained inflammatory responses in the brain (Heneka et al., 2015; Nakanishi et al., 2018). However, the molecular mechanisms by which specific Aβ conformations influence inflammasome assembly remain incompletely understood.This study aimed to investigate whether distinct aggregation states of amyloid β42 (Aβ42) are …

Journey Of Becoming: Risk And Self-Determination In The Story Of Self For Adults With Intellectual, Developmental, And Learning Disabilities A Phenomenological Case Study Employing Narrative Inquiry And Thematic Analysis, Christopher R. J. Worth

Dissertations

This phenomenological case study, employing narrative inquiry and thematic analysis, captured the first-person voice of emerging adults (ages 20–28) with intellectual, developmental, and learning disabilities to explore how experiences of risk and self-determination shaped their personal narratives, or story of self. Guided by Critical Disability Theory, Foucault’s concept of relational power, and Shogren’s Causal Agency Theory, the study challenged the systemic bubble-wrapping that denies this population the "dignity of risk" (Perske, 1972). Data were collected from six participants through semi-structured interviews, adapted photovoice submissions, and participant selfreflections. The findings revealed that the phenomenon of becoming, catalyzed by intellectual adaptive risk-taking, …

Teachers' Perceived Impact Of Teacher-Led Committees On Agency And Morale, Sherry Wibben

Dissertations

The action research study examined how participation in teacher-led committees influenced teachers’ perceptions of agency and morale within an urban Midwestern high school. Grounded in theories of shared and distributed leadership, the study addressed a problem of practice centered on limited teacher voice, fragmented communication, and inconsistent collaborative structures. A convergent mixed-methods design was employed to evaluate changes in teacher morale and professional agency following implementation of teacher-led committees.

Quantitative data were collected using Wong’s (1991) Staff Morale Questionnaire (SMQ), measuring leadership synergy, cohesive pride, and personal challenge. Surveys were administered at baseline (N = 30) and endline ( …

Cripping The Border – Acompañamiento As Access: An Ethnographic Case Study Of Transborder Youth With Disabilities, Marco O. Amaral

Dissertations

The U.S.-Mexico border is a historical, geopolitical site of intense militarization where colonial logics of "othering" converge to marginalize disabled transborder youth. While transborder studies have expanded, students with disabilities remain relegated to the "void" and contained by educational systems that prioritize surveillance over access. Grounded in Sepúlveda’s (2011) acompañamiento and Transborder DisCrit, this ethnographic case study examines the lived experiences of both students and their families who cross the border daily to attend school in the U.S. It frames these journeys not as mere commutes, but as acts of defiance within the broader disability rights movement.

As a teacher-activist, …

Organizing To Engage: A Framework For Conflict Strategy, Paul Mason Carpenter

Dissertations

Conflict strategy can be exceedingly complex. While many of the basics are simple, even the simple can be highly complicated to execute. The Schlieffen Plan in World War I appeared straight forward, but execution was a great deal more complex. It failed and the result was years of trench warfare.  In addition, leaders entering conflict may not fully appreciate the full context, its effect, and the need for a long term result--a better state of peace.

Strategy and tactics may be challenging to transform as an engagement evolves. In addition, strategists must often commit to courses of action within very …

Exploring The Impact Of Mental Health On Academic Performance And Engagement: An Interpretative Phenomenological Study Of Title I High School Upperclassmen In Northeast Alabama, Nataysia A. Holloway

Dissertations

This dissertation explores the intersection of student mental health and academic success within a Title I school context, particularly the lived experiences of students navigating mental health challenges while facing psychological, social, and educational barriers. Drawing on qualitative data, the study explores how mental health challenges influence student academic performance, engagement, and overall educational outcomes. Chapter one introduces mental health as a prevalent concern for adolescence, and chapter two examines existing research and details the methodological approach and supporting frameworks for this study. Subsequent chapters are devoted to the lived experiences of students and their perception of support and resources …

The Intersection Of Social Desirability And Cultural Competence In Counselors: Broaching Sexual Topics With Sexually Minoritized (Lgb) Clients, Jareb Kinney

Dissertations

Mental health counselors increasingly work with sexually minoritized clients, yet limited understanding exists regarding how social desirability shapes counselors' perceived cultural competence and their willingness to broach sensitive sexual topics in therapeutic settings. This gap can obscure the subtle ways personal conditioning and professional performance pressures influence clinical practice. This qualitative phenomenological study aimed to explore how social desirability influences mental health counselors' experiences and perceived cultural competence when discussing sex-related topics with sexually minoritized clients. Guided by symbolic interactionism, the study employed a purposive and snowball sampling strategy to recruit ten mental health counselors with direct clinical experience serving …

“I Should’Ve Listened!”: Lived Experiences Of Postsecondary Transitions Among Students With Emotional And Behavioral Disorders From Non-Traditional High Schools, Kristen De Rose

Dissertations

This phenomenological study explored the lived experiences of former students with EBD who attended a non-traditional high school. Eight semi-structured individual interviews were conducted to understand how students experienced emotional and academic supports during high school and throughout the transition into adulthood. Results revealed that participants appreciated attending a non-traditional school for its school connectedness, emotional and instructional supports, and school-based counseling. Additionally, findings suggest the school did not prepare them for the transition to post-secondary life. These findings suggest that emotional and academic support for students with EBD in non-traditional high school settings positively affected students’ sense of success …

The Ballot Question: Citizen Initiatives, Institutions, And The Policy Process, Ty Rhoads

Dissertations

State-level policymaking remains undertheorized relative to its federal counterpart, particularly in states where institutionalized direct democracy creates a parallel channel for policy change outside the legislature. This dissertation develops a novel theoretical framework for the state policy process by adapting punctuated equilibrium theory to American state politics, integrating it with party cartel theory and the concept of legislative policy monopolies. The central argument is that citizen initiatives and legislative referrals are structurally distinct policy venues whose ideological profiles, policy magnitudes, and electoral dynamics are systematically shaped by the partisan context of the legislature. Using Missouri as a case study spanning …

Optical Fiber Sensors Using Vernier Effect In Cascaded Fiber Interferometers, Zhouchen Wang

Dissertations

The optical Vernier effect has emerged as a powerful tool to enhance the sensitivity of optical fiber interferometer-based sensors, opening new opportunities for developing highly sensitive fiber sensing systems. Optical fiber interferometric sensors based on the Vernier effect are widely used for various applications due to their ultra-compact size, high sensitivity, immunity to electromagnetic interference, electrical isolation, resistance to harsh environments, flexibility, multiplexing capability, and remote operation. The aim of this doctoral thesis was to gain a deeper fundamental understanding of the Vernier effect in optical fiber structures and to develop and investigate a series of novel Vernier effect optical …