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Parenting For Wellness: Positive Parenting Factors As Predictors Of College Student Physical Health, Mental Health, And Social Connectedness Through The Lens Of Self-Determination Theory, Mary E. Lamkin Aug 2025

Parenting For Wellness: Positive Parenting Factors As Predictors Of College Student Physical Health, Mental Health, And Social Connectedness Through The Lens Of Self-Determination Theory, Mary E. Lamkin

Dissertations

Research suggests that the transition to college can impact college student well-being across the domains of physical health, mental health, and social connectedness (Frech, 2012; Pittman & Richmond, 2008; Xiao et al., 2017). As parents are more heavily connected to their college-aged students when compared to years before cell phones and social media, they likely continue to play a significant role in their child’s well-being, even while they are in college (Wartman & Savage, 2008). Therefore, the aim of this dissertation was to investigate positive parenting behaviors as predictors of wellness in college-aged participants using Self Determination Theory (Ryan & …


A Brief Cognitive-Behavioral Intervention For Emotion Regulationand Aggression In Justice-Involved Adolescents: Preliminary Outcomes From A Non-Randomized Trial In Short-Term Juvenile Detention, Cassidy L. Tennity Aug 2025

A Brief Cognitive-Behavioral Intervention For Emotion Regulationand Aggression In Justice-Involved Adolescents: Preliminary Outcomes From A Non-Randomized Trial In Short-Term Juvenile Detention, Cassidy L. Tennity

Dissertations

Justice-involved youth are at risk for a variety of psychosocial difficulties, including anger, aggression, and emotion regulation challenges. Short-term juvenile detention settings offer a unique opportunity to provide psychological interventions to youth before they are returned to the community or sentenced to long-term placements. However, implementation barriers within these settings often hinder the delivery of evidence-based care. This study developed and tested a brief, two-session anger management intervention for adolescents detained in a short-term juvenile detention center in the Southeastern United States, drawing on evidence-based practices from prior work with justice-involved youth. The present study examined implementation outcomes (i.e., feasibility, …


Lesbian, Gay, Bisexual, Transgender, Gender Expansive, And Queer+ Client Experiences Discussing Consensual Nonmonogamy In Therapy: An Interpretive Phenomenological Analysis, Evan Wendell Engle-Newman Aug 2025

Lesbian, Gay, Bisexual, Transgender, Gender Expansive, And Queer+ Client Experiences Discussing Consensual Nonmonogamy In Therapy: An Interpretive Phenomenological Analysis, Evan Wendell Engle-Newman

Dissertations

This dissertation presents the findings from an Interpretive Phenomenological Analysis (IPA) study on how lesbian, gay, bisexual, transgender, gender expansive, and queer+ (LGBTGEQ+) clients experience discussing consensual nonmonogamy (CNM) in therapy. This study explored how five individuals made meaning of their experiences discussing CNM with current or prior therapists. The meaning they made of these experiences were situated in the context of social and cultural factors that influenced their discussions of CNM in therapy.

There were three research questions for this study including one primary question and two guiding sub-questions. The primary question was: what are the experiences of LGBTGEQ+ …


From Foster Care To College Graduation: A Qualitative Study Of The Experiences Of College Graduates Who Aged Out Of Foster Care, Antonia Irene Thomas Aug 2025

From Foster Care To College Graduation: A Qualitative Study Of The Experiences Of College Graduates Who Aged Out Of Foster Care, Antonia Irene Thomas

Dissertations

Students who have spent time in the foster care system encounter a myriad of barriers and challenges to academic success. Among these challenges is attending post-secondary school and completing a college degree. High school academic performance, knowledge of the college application process, and lack of financial support are some factors that act as barriers to post-secondary attendance. Lack of support and difficulty navigating the college experience can negatively impact the ability to complete college. Even in instances of desire and academic ability to attend college, many of these students never attend, or do not complete and obtain a degree. Between …


Beliefs Of California And Colorado Parents, School Professionals, And School Administrators Around Providing Comprehensive Sexuality Education To School-Aged Youth With Intellectual And Developmental Disabilities, Michelle Aleen Kalos Aug 2025

Beliefs Of California And Colorado Parents, School Professionals, And School Administrators Around Providing Comprehensive Sexuality Education To School-Aged Youth With Intellectual And Developmental Disabilities, Michelle Aleen Kalos

Dissertations

People with intellectual and developmental disabilities (IDD) are victims of sexual assault at a rate seven times higher than people without IDD (Shapiro, 2018a). “One of the best ways to stop sexual assault is to give people with intellectual disabilities the ability to identify abuse and to know how to develop the healthy relationships they want” (Shapiro, 2018b, p. 1). Comprehensive sexuality education (CSE) could be a scientifically accurate, evidence-based, age-appropriate, culturally relevant, and inclusive educational experience for youth with IDD (Koch et al., 2024). However, only around 16% of students with IDD were likely to receive sex education in …


Students’ Ability To Transfer Organic Chemistry Concepts To Metabolic Reactions, Timothy Jones Aug 2025

Students’ Ability To Transfer Organic Chemistry Concepts To Metabolic Reactions, Timothy Jones

Dissertations

Bridging foundational knowledge learned in prerequisite courses like organic chemistry to higher-level courses like biochemistry represents a significant challenge in science education, often hindering deeper student understanding and future knowledge application. The purpose of this dissertation was to investigate students’ ability to transfer and apply their understanding of organic chemistry when reasoning through metabolic reaction problems often seen in biochemistry courses. The research questions guiding the project were two-fold:

Q1 What are the organic chemistry reaction concepts deemed foundational to understanding metabolism by experts in the field?

Q2 What is the student’s ability to transfer knowledge of organic chemistry reactions …


Teacher Leadership In Social Studies: The Search For Meaning And Identity, Zachary F. Lawson Aug 2025

Teacher Leadership In Social Studies: The Search For Meaning And Identity, Zachary F. Lawson

Dissertations

This qualitative research study brings together social studies education and teacher leadership. Social studies lacks study in the teacher leader literature. This study aimed to understand whether the disciplinary nature of social studies education influenced the enactment of teacher leadership. This study sought an answer to the central research question: What does it mean to be a social studies teacher leader? Using a hermeneutic phenomenology research design, data were collected through semi-structured interviews across two groups of participants. Seven social studies teacher leaders made up one group, and five social studies teachers without leadership roles comprised the other. Findings indicated …


Cultivating Belonging: Empowering Hispanic Parents In The U.S. Education System, Kalpana Galagali Jul 2025

Cultivating Belonging: Empowering Hispanic Parents In The U.S. Education System, Kalpana Galagali

Dissertations

This qualitative study explores the experiences of Hispanic families at Bay Area Middle School and the strategies I employed to create a sense of belonging and support for both students and their families. Key strategies included fostering effective communication through Spanish interpreters, celebrating cultural traditions, and organizing inclusive events like the annual cultural fair. Parents expressed gratitude for the personal attention their children received and noted how these initiatives positively impacted their sense of belonging. The findings highlight that cultural integration and community-building efforts significantly enhanced family engagement, transforming perceptions of the school environment from feelings of disconnection to appreciation …


Implementation Of Quantitative Blood Loss To Detect Postpartum Hemorrhage After Vaginal Birth, Raven S. Simpson Jul 2025

Implementation Of Quantitative Blood Loss To Detect Postpartum Hemorrhage After Vaginal Birth, Raven S. Simpson

Dissertations

Problem: In the U.S., postpartum hemorrhage (PPH) is attributed to maternal morbidity and mortality, resulting in long-lasting effects of extended recoveries, surgical interventions, birth-related trauma, interruptions in mother-infant bonding, or death. Performing estimated blood loss (EBL) measurement methods postpartum is subjective and often associated with over- and underestimations of blood volume. The delay in recognition interferes with timely, efficient, and appropriate interventions, yielding a PPH (≥1000ml).

Methods: A quality improvement (QI) project was initiated with a descriptive, pre-implementation/post-implementation focus on a high-risk Labor and Delivery unit to explore the effects of Quantitative Blood Loss (QBL) measurements on the identification of …


Bowel Regimen Protocol Implementation For Pediatric Patients Following Cardiac Surgery, Eryn Watson Jul 2025

Bowel Regimen Protocol Implementation For Pediatric Patients Following Cardiac Surgery, Eryn Watson

Dissertations

Problem: Pediatric patients with congenital heart disease (CHD) are at an increased risk of constipation following cardiac surgery, which contributes to complications and delays in recovery. Standardized protocols are effective tools for prophylactic management of constipation. However, there is no current standardized protocol in place for postoperative bowel management in a pediatric cardiac intensive care unit (CICU).

Method: This quality improvement project (QI) used a descriptive design with pre- and post-implementation data collection to evaluate the effects of a postoperative bowel regimen protocol on constipation rates and compliance with ordering prophylactic bowel regimens. Convenience sampling was used to identify patients …


Race-Neutral Pft: Implementing Patient Activation Measure Following Race- Neutral Pulmonary Function Testing, Ann M. Way Jul 2025

Race-Neutral Pft: Implementing Patient Activation Measure Following Race- Neutral Pulmonary Function Testing, Ann M. Way

Dissertations

Abstract

Background

The introduction of a race-neutral equation to predict normal values on pulmonary function testing (PFT) has led to changes in the diagnosis of pulmonary diseases previously diagnosed using a race specific equation. Minority patients appear to be most likely impacted by this change, potentially impacting how they self-manage their pulmonary health. Patient self-management can be measured and assessed by using the Patient Activation Measure (PAM) tool.

Purpose

The purpose of this project is to assess patient activation levels amongst minority patients with a new or changed pulmonary diagnosis to identify a possible need for interventions to improve patient …


Depression Screening In The Adult Inpatient Oncology Population, Erica Bizub Jul 2025

Depression Screening In The Adult Inpatient Oncology Population, Erica Bizub

Dissertations

Routinely screening oncology patients for depression is recommended due to the higher rates of depression in this population as well as the negative impact of untreated depression. The goal of this QI project is to implement a standard depression screening protocol for patients admitted to this hospital, where there is currently no standard screening protocol. There were 110 patients included in this study, and 67 (60.91%) of patients received a PHQ-9 screening. Of the patients who completed the PHQ-9, 21 (19.09%) had a positive screening, which was a score of seven or higher. While there were high rates of provider …


A Program Evaluation: Insomnia In Adults With Major Depression Disorder With Cognitive Behavioral Therapy For Insomnia (Cbt-I), Taylor E. Wilson Jul 2025

A Program Evaluation: Insomnia In Adults With Major Depression Disorder With Cognitive Behavioral Therapy For Insomnia (Cbt-I), Taylor E. Wilson

Dissertations

Abstract

Problem: In 2023, Compass Health Network (CHN) data analysts found that 91% of CHN patients in the United States who have died by suicide reported problems with sleep, which was the highest risk factor for suicide. The objective of this program evaluation project is to evaluate CHN CBT-I effectiveness on patients ‘suicidality by improving their insomnia.

Methods: CHN quality improvement (QI) project used a quantitative method pre/post score design. Quantitative aggregate data was collected on the participants who met the inclusion criteria via retrospective and prospective chart review prior to CHN implementing the intervention. CBT-I clinicians collected PHQ-9, Columbia-Suicide …


Nanoporous Gold Nanoparticles And Model Membrane Systems Applied To The Study Of Lipopolysaccharide (Lps), Dhanbir Lingden Jul 2025

Nanoporous Gold Nanoparticles And Model Membrane Systems Applied To The Study Of Lipopolysaccharide (Lps), Dhanbir Lingden

Dissertations

Lipopolysaccharide (LPS), a key structural component of Gram-negative bacteria, is a major trigger of sepsis and septic shock, the systemic inflammatory conditions responsible for millions of deaths annually. Even at concentrations as low as 1 ng/mL, LPS can activate the immune system and initiate inflammatory cascades. According to the Global Burden of Disease Study 2017, sepsis accounted for 48.9 million cases globally, with 11 million deaths, emphasizing the urgent need for improved diagnostic and therapeutic strategies.

Accurate and rapid detection of LPS is vital for early intervention and improved clinical outcomes. While traditional detection methods are still widely used, modern …


Screen Foundations: How Pediatric Nurse Practitioners Can Implement ‘Family Media Use Plans’ In Primary Care To Reduce Pediatric Behavior Concerns, Katie Anderson Jul 2025

Screen Foundations: How Pediatric Nurse Practitioners Can Implement ‘Family Media Use Plans’ In Primary Care To Reduce Pediatric Behavior Concerns, Katie Anderson

Dissertations

Abstract for:

Screen Foundations: How Pediatric Nurse Practitioners Can Implement ‘Family Media Use Plans’ in Primary Care to Reduce Pediatric Behavior Concerns

Problem: Parents of children 2-5 years-old increasingly reach out to PCPs for escalating behavior concerns, including when the child doesn’t listen well, is inattentive, having tantrums, meltdowns, hitting, yelling, etc. Referrals to psychiatry and/or play therapy result in long waits, or referrals not accepted. Coincidingly, toddler and preschool aged children continue to exceed daily screen time recommendations. This results in a gap of care for families with young children and externalizing behavior.

Methods: This quality improvement project addressed …


District Impact On State-Wide Charter School Policy: Has Normandy Schools Collaborative Punctuated The Equilibrium? Charter School Policy Analysis Of The Missouri Department Of Elementary And Secondary Education, Tracey L. Cannon Jul 2025

District Impact On State-Wide Charter School Policy: Has Normandy Schools Collaborative Punctuated The Equilibrium? Charter School Policy Analysis Of The Missouri Department Of Elementary And Secondary Education, Tracey L. Cannon

Dissertations

Abstract

Punctuated Equilibrium Theory, as applied by Niles Eldredge and Stephen Jay Gould (1941-2002) to the study of species evolution, examined the infrequency of morphological change or stasis discontinuity.1 While groundbreaking in the field of Paleontology and the study of fossil change, the theory has been well-fitting to the decision sciences as introduced by Baumgartner and Jones2, in their 1993 and 2010 publications. Recognizing typical, incremental policy change, its use in this research looks at how stasis, stagnant policy can be punctuated by changes in political or societal views. This study examines the impact of heightened problem discussion for agenda …


Illuminating Trauma & Resilience In Educational Spaces: Expanding Narratives To Promote Historical And Critical Civic Empathy At Little Rock Central High School National Historic Site, Chakakuan Johnson, Linda Nance, Byron Witherspoon Jul 2025

Illuminating Trauma & Resilience In Educational Spaces: Expanding Narratives To Promote Historical And Critical Civic Empathy At Little Rock Central High School National Historic Site, Chakakuan Johnson, Linda Nance, Byron Witherspoon

Dissertations

Abstract

The 1957 desegregation crisis at Little Rock Central High School marked a defining moment in the Civil Rights Movement and continues to symbolize the broader struggle for racial equality. This dissertation examines equity in educational spaces through a four-truth lens that was first articulated by the South African Truth and Reconciliation Commission and explores forensic, personal, social, and healing truth. Using Little Rock Central High School National Historic Site (CHSC) and park interpretation as the focal point, our qualitative research study used reflexive thematic analysis to examine oral interviews, onsite observations, and various documents and artifacts, and to illuminate …


The Roots Of Our Food: Relationships Are The Seeds Of Care-Based Food Heritage, Nicole E. Post, Raena D. Parsons, Adrian Boone Jun 2025

The Roots Of Our Food: Relationships Are The Seeds Of Care-Based Food Heritage, Nicole E. Post, Raena D. Parsons, Adrian Boone

Dissertations

The purpose of this co-authored, general qualitative research

study was to examine food relationships between individuals,

communities, and Earth. We explored the concept of relational food

systems pertaining to engagement ideas at EarthDance Organic Farm

School and Hawai’i Institute of Pacific Agriculture. Our research

furthers understanding about how to engage people, individually and

collectively, with the land to inspire action. We argue that care-based

relationships can inspire action, helping individuals reconnect with

their food heritage by engaging with land, community, and self.

Heritage site leaders in food systems who center interconnectedness

create places where relationships between people, land, and food …


Enzymatic Characterization Of Bacterial Enzymes And Inhibitors As Potential Antibiotics With New Mechanisms Of Action, Emma Helene Kelley Jun 2025

Enzymatic Characterization Of Bacterial Enzymes And Inhibitors As Potential Antibiotics With New Mechanisms Of Action, Emma Helene Kelley

Dissertations

Bacteria have become increasingly resistant to antibiotics, therefore there is an urgent need for new drug classes of antibiotics to help fight antibiotic infections. To this end, our research is focused on inhibitors of dizinc metalloenzymes N-succinyl-L,L-diaminopimelic acid desuccinylase (DapE), an enzyme in the lysine biosynthesis pathway, N-acetyl-L-ornithine deacetylase enzyme (ArgE), an enzyme in the arginine biosynthesis pathway, and sodium-dependent NADH: ubiquinone oxidoreductase (Na+-NQR) enzyme, a respiratory complex enzyme as promising drug targets. DapE, ArgE, and Na+-NQR and are only present in bacteria, including ESKAPE pathogens that can cause potentially deadly infections, thus inhibitors of DapE, ArgE, and Na+-NQR offer …


Development Of Novel Force Fields For Metal Ions, Madelyn Smith Jun 2025

Development Of Novel Force Fields For Metal Ions, Madelyn Smith

Dissertations

Many biological proteins require the presence of a metal ion in order to properly function. However, metal ions’ complex nature charge poses several challenges to accurately and efficiently simulate computationally. For example, metal ions can exhibit multiple oxidation states, electronic state degeneracy, flexible coordination numbers, and significant polarization effects. To address these problems, this dissertation aims to enhance force fields for modeling metal ions in molecular dynamics simulations. First, a comprehensive set of van der Waals radii for metal ions is derived, demonstrating the importance of using physically meaningful parameters in force fields. Second, a comprehensive set of atomic and …


Modernism’S Mythic Mothers: Queering Motherhood Through Classical Matrilineage, Samantha Marie Lepak Jun 2025

Modernism’S Mythic Mothers: Queering Motherhood Through Classical Matrilineage, Samantha Marie Lepak

Dissertations

I position this dissertation at the intersection of modern/contemporary literature, queer/feminist theory, and ancient Greek classics in the hopes of better understanding the spaces in which they meet, engaging with writers from the late modernist era to the present in order to highlight the connections between theories, themes, and practices of queerness from the modernists forward. Using the work of H.D. and writers following in her footsteps, I argue that exploring adaptations of Greek classics written primarily by female and gender-variant authors from the modernist era forward illuminates the extent to which the classics enables writers to “think queerly,” considering …


Maternal Access For Depression In Rural Environments, Simone Parlier Jun 2025

Maternal Access For Depression In Rural Environments, Simone Parlier

Dissertations

Significance –As many as 25% of birthing persons experience postpartum depression (PPD) within the first year after childbirth making this one of the most common postpartum disorders. PPD is prevalent, incapacitating, and treatable. The first step is identifying those at risk. Rural birthing persons are understudied, and may have unique predisposing characteristics as well as geographic challenges for optimal detection and treatment of PPD. Purpose -The long-term goal is to improve the health of rural families. Using The Theory of Unpleasant Symptoms, the purpose of this descriptive, cross-sectional research was to describe the prevalence of PPD in rural birthing persons …


St. Louis, Missouri’S Gayborhood And Washington, Dc’S Black Lives Matter Plaza: Revealing The Healing Potential Of Resistance Stories That Are Grounded In Place, Ryan R. Lindsay, Lotte I. Lent, Ackesha J. Patrick Jun 2025

St. Louis, Missouri’S Gayborhood And Washington, Dc’S Black Lives Matter Plaza: Revealing The Healing Potential Of Resistance Stories That Are Grounded In Place, Ryan R. Lindsay, Lotte I. Lent, Ackesha J. Patrick

Dissertations

Oppressed people resist, even when facing severe consequences for doing so. At the core of systemic oppression—genocide, slavery, racism, and sexism—is a drive to control and dehumanize. Resistance, however, can serve as a powerful act of rehumanization. From enslaved individuals fleeing plantations to LGBTQ+ individuals risking arrest to gather in mid-20th-century bars, resistance reclaims power and autonomy under oppressive regimes. This study applies South Africa’s Truth and Reconciliation Commission (TRC) “four truths” framework—comprising forensic, personal, social, and healing truths—to the interpretation of contested heritage sites. We argue that sites commemorating resistance hold transformative potential for individual and community healing. Using …


Toward Culturally Responsive Interpretation: Native American Histories, Lifeways, And Ways Of Knowing At The High Desert Museum, Carol Fitzsimmons, Ajena Cason Rogers Jun 2025

Toward Culturally Responsive Interpretation: Native American Histories, Lifeways, And Ways Of Knowing At The High Desert Museum, Carol Fitzsimmons, Ajena Cason Rogers

Dissertations

Many public museums and historic institutions reflect settler colonial culture and are primarily non-Native led. Although these institutions are trusted, many have perpetuated cultural harm through the theft of belongings, the misrepresentation of stories and histories, and the inaccurate portrayals of cultural content. When interpreting Native American experiences, many non-Native institutions struggle to co-create culturally responsive interpretation. The purpose of this basic qualitative study was to apply the four-truth framework, developed by the South African Truth and Reconciliation Commission, to better understand how the High Desert Museum approached the interpretation of Native American content and stories and to explore how …


Investigating The Consequences Of Conjugated And Secreted Isg15 On Coronavirus Pathogenesis, Mudassir Syed Ali Jun 2025

Investigating The Consequences Of Conjugated And Secreted Isg15 On Coronavirus Pathogenesis, Mudassir Syed Ali

Dissertations

Coronaviruses have evolved a breadth of mechanisms to antagonize host innate immune responses. One widely studied mechanism is the ability to deconjugate ISG15 from target proteins in a process called deISGylation, which is catalyzed by the papain-like protease (PLP) domain of viral non-structural protein (nsp) 3. Since PLP activity is required for viral replication, it has been challenging to generate an infectious virus with a PLP that maintains protease activity but has lost deISGylase activity. In this study, we generated a chimeric MHV-A59 with its PLP2 domain replaced with that of the human coronavirus HKU1, which has been documented to …


Pyruvate Dehydrogenase Kinase 4 Mediates Sex Specific Outcomes In Sepsis Induced Cardiomyopathy, John Yap Jun 2025

Pyruvate Dehydrogenase Kinase 4 Mediates Sex Specific Outcomes In Sepsis Induced Cardiomyopathy, John Yap

Dissertations

During sepsis, males often experience worse cardiac outcomes than females. Here, we identified pyruvate dehydrogenase kinase 4 (PDK4) as a key contributor to this disparity. PDK4 is a mitochondrial protein that regulates glucose utilization by inhibiting pyruvate dehydrogenase (PDH). Using a mouse model of endotoxemia, we induced acute inflammation with a sublethal dose of lipopolysaccharide (LPS), which caused cardiac dysfunction and significantly increased myocardial PDK4 expression in males but not females. Cardiac-specific PDK4 overexpression promoted LPS-induced cardiac dysfunction in both sexes, whereas cardiac-specific PDK4 knockout provided protection. In wild-type males, LPS disrupted cardiac metabolism by decreasing PDH activity and fatty …


Targeting Eya1 Phosphatase Activity In Mll-Rearranged Leukemia, Lola Badmus Jun 2025

Targeting Eya1 Phosphatase Activity In Mll-Rearranged Leukemia, Lola Badmus

Dissertations

MLL-rearranged (MLL-r) leukemia is an aggressive subset of acute leukemia, accounting for up to 10% of adult and 70% of infant AML and ALL cases. These leukemias are driven by MLL fusion proteins, which recruit epigenetic cofactors to dysregulate gene expression, leading to poor prognosis and resistance to conventional chemotherapy. Previous lab work identified EYA1’s role in leukemogenesis, establishing it as a therapeutic target in MLL-r leukemia. EYA1, is a transcriptional coactivator and protein tyrosine phosphatase (PTP). Originally a gout medication, benzbromarone (BBR), was identified in an NCI Diversity Set screen as an EYA1-specific PTP inhibitor. BBR provides a tool …


Developing Full Performance Interpreters: Cultivating Interdisciplinary Mindsets And Skillsets To Engage Audiences In Climate Change, Women's History, And Other Contested Heritage Topics, Delia A. Lister Jun 2025

Developing Full Performance Interpreters: Cultivating Interdisciplinary Mindsets And Skillsets To Engage Audiences In Climate Change, Women's History, And Other Contested Heritage Topics, Delia A. Lister

Dissertations

Heritage sites immerse visitors in places where the impacts of climate change are readily apparent. They are also powerful places to elevate untold stories of women and girls. Heritage site interpreters interact daily with audiences who bring diverse lived experiences, different levels of subject matter knowledge, and multiple perspectives on climate change and the role of women in history. Every visitor interaction has a set of meanings, values, and narratives that visitors knowingly or unknowingly espouse. To interpret contested heritage topics, such as climate change and women’s history, interpreters must cultivate interdisciplinary mindsets and skillsets. The purpose of this basic …


Comparative Genotoxicological Analysis Of Occupational Pesticide Exposures: An Experimental Approach And Systematic Review, Moustafa Samy Sherif Jun 2025

Comparative Genotoxicological Analysis Of Occupational Pesticide Exposures: An Experimental Approach And Systematic Review, Moustafa Samy Sherif

Dissertations

This dissertation investigates the genotoxic and cytotoxic effects of pesticide exposure through three complementary research components: a systematic review of occupational pesticide exposure in Arab countries (AraSys), a systematic review on encapsulated versus conventional pesticide formulations (Encap-Sys), and experimental toxicological assessments of various pesticide formulations in human cell lines (Pyr-Ex). This experimental component includes cytotoxicity assays using propidium iodide and DNA damage assessments via alkaline comet assays in HL60 and HepG2 cell lines exposed to pyrethroid insecticides and glyphosate-based formulations.

The AraSys systematic review revealed a critical positive association between occupational pesticide exposure and DNA damage in agricultural workers in …


Design And Development Of Hip Implants For Longevity Through Integrating Advanced Groove Structures And Additive Manufacturing, Asarudheen Abdudeen Jun 2025

Design And Development Of Hip Implants For Longevity Through Integrating Advanced Groove Structures And Additive Manufacturing, Asarudheen Abdudeen

Dissertations

This doctoral research concerns the design and optimization of hip implants (HIs) to enhance performance, durability, and improve patient outcomes by addressing the key issues of wear, deformation, and stress distribution. Innovative surface groove designs have been introduced to both a solid and a hollow femoral head with the aim of reducing friction and wear. The addition of grooves, with both a hemispherical and rectangular cross-section, onto the femoral head reduced friction, as debris produced by the inner liner was trapped within the grooves, significantly reducing adhesive wear. A numerical simulation study compared the effects of surface modifications both grooves …