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Defining A Role For Inducible Heat Shock Protein 70 (Hsp70i) In Mediating Autoimmune Vitiligo, Jeffrey Alan Mosenson

Dissertations

Vitiligo is an autoimmune disease characterized by destruction of melanocytes, leaving 0.5% of the population with progressive depigmentation. Current treatments offer limited efficacy. Observations that heat shock proteins (HSPs) can serve as adjuvants in antitumor vaccines first suggested to us a link between HSPs and stress-induced vitiligo. Such proteins are marvelously well conserved throughout evolution, which has placed them in the spotlight for helping to understand the intriguing relationship between infection and immunity. Intracellularly, inducible heat shock protein 70 (HSP70i) is upregulated by stress and helps protect cells from undergoing apoptosis. In times of stress, melanocytes will secrete antigen bound …

The Religion Of Consumption And Christian Neighbor Love, Christopher Porter

Dissertations

Loyola University Chicago

THE RELIGION OF CONSUMPTION AND CHRISTIAN NEIGHBOR LOVE

Consumerism is a word frequently used in various disciplines to express the variety of attitudes, motivations, and practices found among the middle and upper classes. It drives the global economy and influences individuals' socio-psychological perceptions. Some have gone so far as to call consumerism a religion, yet they have not substantiated this claim. This dissertation offers a framework that accounts for consumerism as a religion both as a person's ultimate concern and as a structuralized belief system. As such, it prescribes moral values that shape how people respond to …

The Rebel Leader: A Sequential Explanatory Mixed Methods Analysis Of Rebel Superintendents In Suburban Public Schools, Christopher Leigh Finch

Dissertations

The term rebel is virtually nonexistent in academic literature within the field of educational leadership and maintains a generally negative connotation. This research is intended to cast the term in a new light and allow for conceptualization of the word as a positive descriptor for educational leaders. This study explored the impact and efficacy of rebel superintendents within suburban K-12 public school districts. Following a sequential explanatory mixed method design, participant selection was conducted using the Kirton Adaption-Innovation Inventory (KAI) as a quantitative participant selection tool. Nine superintendents were identified using the KAI and interviewed. Three superintendents were identified as …

An Investigation Of Chinese Graduate Student Understanding Of Academic Integrity In U'S Higher Education, James E. Hammerschmidt

Dissertations

Recent studies suggest that plagiarism in U.S. higher education may be more of an issue among Chinese graduate students. When Chinese graduate students are accused of plagiarizing an implicit assumption often exists that poor language skills or lack of integrity may be the cause. The failure to consider cross-cultural issues in learning may have led to these views. An examination of previous learning experiences in the Chinese graduate student's home country was needed in order to obtain a deeper understanding of how culture enters into their understanding of academic dishonesty. This study seeks to a.) explore the understanding and meaning …

Identity Negotiation Of Young Arab Muslim Women Attending College In The United States And France, Danielle Dunand Zimmerman

Dissertations

The purpose of this phenomenological study was to explore how young Arab Muslim women attending college, in the United States and France, negotiate their identity vis-à-vis multiple contexts of citizenship in secular state, gender, religion, culture, and race. Sixteen interviews were conducted, eight in Paris and eight in Chicago. Using the theoretical frameworks of social identity, cultural studies, and critical race feminism, this study approached identity negotiation in terms of integration and differentiation from others; influence of dominant culture and attempt to redefine identity; gender and specificity of the experience of women of color as well as interrelation of multiple …

Examining Predictive Validity And Rates Of Growth In Curriculum-Based Measurement With English Language Learners In The Intermediate Grades, Ella Farmer

Dissertations

In the current educational climate, school districts and states are being held accountable for the progress of all students. Students who speak another language at home and have limited English proficiency, known as English Language Learners (ELLs), continue to underperform when compared to English proficient peers. The purpose of the study was to determine whether a brief, standardized reading fluency probe (R-CBM) is an effective tool for measuring growth over time and identifying students at risk of failure of a state standards test, considering ELL status. Archival data was used with a sample of 1,056 students in fourth through sixth …

Novel Role Of Erbb-2 In Inhibition Of Jagged-1-Mediated Trans-Activation Of Notch In Breast Cancer, Kinnari Pandya

Dissertations

The ErbB-2 gene is amplified and the resulting protein product overexpressed in 15-30% of breast tumors, and associated with aggressive behavior and poor overall survival. Currently, there are two FDA approved therapies targeting ErbB-2 for the treatment of ErbB-2 positive breast cancer: trastuzumab, a humanized monoclonal antibody is directed against the extracellular domain of ErbB-2 and lapatinib, a dual EGFR/ErbB-2 tyrosine kinase inhibitor. Unfortunately, anti-ErbB-2 therapy resistance remains a major problem in metastatic breast cancer. Our data suggested that gene amplification or overexpression of ErbB-2 inhibits Notch-1 transcriptional activity and trastuzumab or lapatinib increased

Notch-1 transcriptional activity. Furthermore, Notch-1 is …

Cheerleaders And Performers: Mental Health Courts In A Midwestern State, Monte Staton

Dissertations

"Cheerleaders and Performers: Mental Health Courts in a Midwestern State" by Monte D. Staton

This dissertation presents a statewide study focusing on a recently developed technique for dealing with persons with mental illness in the criminal justice system: mental health court (MHC). This study of nine MHC programs utilized surveys, interviews, and ethnographic observations to examine the work activities and understandings of the criminal justice and mental health professionals who administer and operate the programs in a Midwestern state. Data were analyzed by combining Goffman's dramaturgical analysis with Dorothy E. Smith's institutional ethnography. Findings reveal that MHC professionals engage in …

The Costumed Catholic: Catholics, Whiteness, And The Movies, 1928 - 1973, Albert William Vogt Iii

Dissertations

Abstract

This dissertation examines the impact movies had on the place of Catholics of European descent in mainstream white America. Most scholars who study the history of Catholic populations in this country assume that they attained whiteness at some point. Whether with the Irish in the late nineteenth century, or more generally when urban parishes began the move to the suburbs post-World War II, the historiography claims that Catholics earned white status. However, an analysis of twentieth century American film complicates the historiography of Catholicism. A set of negative stereotypes, instead, have colored the presentation of the religion in cinema …

Understanding The Posttranslational Regulation Of The Response Regulator Rcsb And Acetyl Phosphate As An Acetyl Group Donor In E. Coli, Linda Hu

Dissertations

The observation that Nepsilon-lysine acetylation occurs on a hundreds of proteins in bacteria is a recent discovery. To study the mechanisms that regulate acetylation and to determine if acetylation affects physiology, I studied the Escherichia coli response regulator and transcription factor RcsB, which was reported to be acetylated in vitro. To monitor RcsB activity, I measured transcription from the rprA promoter, which requires RcsB. I confirmed that RcsB is activated by phosphorylation through the Rcs phosphorelay and acetyl phosphate and showed that acetyl phosphate could phosphorylate RcsB. However, a mutant that accumulates acetyl phosphate (ackA) exhibited reduced rprA transcription instead …

Religious Pluralism And The Catholic Church: Lonergan's Method And The Jacques Dupuis Controversy, Andrea J. Stapleton Berger

Dissertations

This project applies Lonergan's method to the controversy that resulted from the censure of Jacques Dupuis by the Congregation for the Doctrine of the Faith over his book, Toward a Christian Theology of Religious Pluralism. The application of Lonergan's method reveals the potential for the resolution of the issues presented by Dupuis in the area of developing a Catholic theology of pluralism as well as the tension between the Catholic Magisterium and the work of Catholic theologians.

Particulates Initiate Immune Response Via Inducing Oxidative Stress-Mediated Nlrp3 Inflammasome Activation, Zhenyu Zhong

Dissertations

Liposomes are lipid particles formed by self-aggregated phospholipids. They are clinically used both as delivery vectors and immune adjuvants to treat many human infectious and cancerous diseases. However, how liposomes interact with host immune system remains poorly understood. Particularly, little is known about whether an innate immune receptor exists to sense liposomes. I hypothesize that liposomes activate NLRP3 inflammasome in macrophages, which results in the release of interleukin 1β (IL-1β), a proinflammatory cytokine that plays a key role in innate and adaptive immune responses.

To test my hypothesis, I determined the ability of inducing IL-1β secretion from macrophages by differentially …

Family Science: An Ethnographic Case Study Of The Ordinary Science And Literacy Experiences Of One Family, Glenda Margaret Mccarty

Dissertations

Despite the copious research available on science learning, little is known about ways in which the public engages in free-choice science learning and even fewer studies have focused on how families engage in science to learn about the world around them. The same was true about studies of literacy development in the home until the 1980s when researchers (e.g. Bissex, 1980; Heath, 1983; Taylor, 1983) began documenting the literacy happenings and practices of young children in natural settings. Findings from intensive emergent literacy research studies have challenged traditional approaches to the teaching and learning of literacy, especially drawing attention to …

Identification And Management Of Vertebral Column Fractures In Primary Care, Christopher Richard Hemmer

Dissertations

The purpose of this project is to perform a program evaluation of current treatment patterns of primary care providers for osteoporotic vertebral compression fractures (VCF). VCF’s result in significant morbidity and long term sequelae following a VCF is not uncommon. Additionally, there is controversy regarding the diagnosis and management of this disorder, especially as these relate to the clinical practice guidelines. This practice evaluation project included a pre and post-test survey and a continuing education offering. Thirty-nine physicians and nurse practitioners completed the survey instruments and attended the continuing education sessions. The educational session resulted in improvement of the provider’s …

Narrative Identities Of American Muslim Women In A Midwestern City, Emily Anastasia Hager

Dissertations

In the years since September 11, 2001, increased racial profiling changed what it means to be an Arab, and/or Muslim in the United States. While a small but growing number of studies have focused on Arab-American adolescents and identity development (Chadhury, 2008; Sarroub, 2002), few have studied those who were “emerging adults” (Arnett, 2000) at the time of the attacks, or analyzed how they construct their current lifespan narratives (McAdams, 2006) in light of the national discourse linking terrorism and Islam. To fill this gap in the literature, my study explored the links between community discourse and narrative identity development …

Marine Fungi Of U.S. Gulf Of Mexico Barrier Island Beaches: Biodiversity And Sampling Strategy, Allison Kathleen Walker

Dissertations

Marine fungi are an important but often overlooked component of marine ecosystems. Primarily saprotrophic, they are vital to coastal nutrient cycling processes and food webs. However, basic marine fungal distribution data are lacking in many parts of the world, as is knowledge of the sampling intensity required to characterize the biodiversity of these communities. The roles of substrate, season and latitude in shaping intertidal ascomycete community structure were examined for the U.S. Gulf of Mexico, and the role of sampling frequency on species richness estimates was also addressed. Best sampling practices were developed and 750 collections of beach detritus, sand …

The Impact Of Competition In Forensics On Future Careers, Jace Thomas Lux

Dissertations

Each year, thousands of college students participate in forensics (competitive speech and debate). Despite previous studies that identify numerous benefits to forensics participation, the activity is often eliminated from college campuses due to financial constraints. Although previous literature identifies the benefits of forensics participation to competitors, these studies do not address the lasting impact of college forensics participation on the careers of former competitors.

This exploratory study sought to identify the forensics outcomes that former competitors felt are used most frequently in their current careers, as well as the amount of emphasis forensics programs are placing on teaching these particular …

Religious Leaders In Crisis: An Analysis Of Image Restoration Strategies And Content Variables, Melody Teracita Fisher

Dissertations

The following study employs content analysis to examine the crisis communication responses and audience reception of religious leaders involved in scandal. Benoit’s Image Repair Strategies and the Contingency Theory are used to determine the strategies, stances and contingent variables of mega-church leaders: Jim Bakker, Ted Haggard, Eddie Long, Henry Lyons and Jimmy Swaggart; and the Boston Diocese of the Roman Catholic Church. News framing theory determined media and audience reception of the religious leaders’ crisis communication responses.

The study concludes that there is little difference in mega-church leaders and the Boston Diocese’s crisis communication responses. Religious leaders’ dominant strategies were …

"If It Ain't Broke, Break It": How Corporate Journalism Killed The "Arkansas Gazette", Donna Lampkin Stephens

Dissertations

Ownership is an increasingly critical issue for newspapers as they face the latest threats to the industry’s survival. Local, engaged, enlightened ownership is preferable to that of a distant corporation, but economic realities have decreed that corporate ownership has become the norm. The Arkansas Gazette was one of the most honored newspapers of twentieth-century American journalism under independent local family ownership, having provided brave leadership during the Little Rock Central Crisis, but its wounds from one of the country’s final fierce newspaper wars — against another local owner, Walter Hussman and his Arkansas Democrat — in the 1980s, combined with …

Financial Communication In Romantic Relationships, Joy Nichole Smithson

Dissertations

Previous research indicates that financial disagreements are common among romantic couples. However, little theoretical development has been offered to explain such disagreements. This study integrates several areas of research pertinent to financial conflict, and proposes two typologies to explain couples’ recurrent arguments over finances. The first typology concerns financial attitudes that work together to create a financial style. The second typology concerns financial power in the relationship, which is comprised of contribution to household funds, dominance in financial decision-making, and keeping money separate from one’s partner.

Dyadic data was collected from 80 couples to test the typologies. Analyses revealed that …

Employee Racial Discrimination Complaints: Exploring Power Through Co-Cultural Theory, Leslie Yvette Rodriguez

Dissertations

The primary purpose of this case study was to examine the influence of power on an employee’s decision to file a formal racial discrimination complaint against their employer with the Equal Employment Opportunity Commission (EEOC). Additionally, this case study explored the communicative strategies that lead up to and follow the filing of such a complaint. This study used both Orbe’s (1998) co-cultural theory and French and Raven’s theory on power bases (1968) as both theoretical foundations and lenses to analyze this occurrence.

Four minority women from Central Texas participated in this qualitative case study. Specifically, in depth interviews were conducted …

Quantifying Vulnerability After The Storm: Hurricane Katrina Case Study, Jennifer Lori Bonin

Dissertations

We can predict social and physical vulnerability with relatively accurate modeling. There are, however, very few consistent models to predict economic vulnerability outside of loss estimation models designed by economists. The index in this dissertation predicts which areas are most economically vulnerable in terms of job loss. Communities rely on their ability to work and contribute to the tax base. Without that base, a community will take longer to recover after a disaster. Which industries, professions, and environmental factors most influence a community’s economic vulnerability in the wake of a disaster? This dissertation presents an index for measuring economic vulnerability …

Million Dollar Plus Donors Within Intercollegiate Athletics: A Qualitative Analysis Of Donor Motivations, Nancy Carol Hixson

Dissertations

No abstract provided.

An Investigation Of Preservice Teachers' Perceptions Of Locus Of Control, Self-Regulation, And Motivation In Online Learning, Sung-Ho Min

Dissertations

No abstract provided.

Theater Percussion: Developing A Twenty-First-Century Genre Through The Connection Of Visual, Dramatic, And Percussive Arts, Julie J. Strom

Dissertations

Theater percussion, as it shall be referred to for the purpose of this dissertation, is an existing, yet unnamed, genre characterized by a systematic approach of combining percussion with extra-musical components that tap into senses or aspects of sentiment - visually, aurally, and emotionally, and are made possible with the use of compositional additives - acting, movement, text, and multimedia avenues such as audio and video. To complete the process, these extra-musical elements are combined with the main musical influence - a composition for percussion ensemble or soloist. Several pieces in this style have and continue to be performed by …

Health And Relationship Variables Impacting Psychological And Social Well-Being Among Predominantly White Middle Class Adults 65 And Older Who Receive Assistance With Their Care From Family Members, Alyssa C. Ford

Dissertations

The majority of care to persons 65 and older in the United States is provided by family members. Previous research among older adults who receive assistance with their care from family or friends, while sparse, has identified variables that appear to impact the well-being of such persons. These variables include reciprocity, dignity, self-perceived burden, mental health status, and physical health or disability status. However, these variables have not been studied together. The purpose of this dissertation research was to examine these variables individually and collectively as they relate to well-being.

A sample of 71 adults, ages 68 to 97, who …

Personality And Religiosity: The Influence Of Normative Personality On Black Sunni Muslims' Religious Attitudes And Practices, Halim Khidher Naeem

Dissertations

There is a dearth of literature on Black Sunni Muslims in the field of psychology. More so, there is no literature specifically analyzing the influences upon Black religiosity. The literature has established that personality has significant influence upon religiosity. The literature also says that females are more religious than their male counterparts. The present study analyzed the influence of personality, gender and social class upon religiosity for Black Sunni Muslims. The following hypothesis was investigated: Personality, gender, and social class will affect religious attitudes and practices.

A canonical regression analysis using SPSS revealed that personality, gender and social class had …

Attitudes Toward Science And Stem Cell Research Based On Religious Worldview: Comparing The Views Of Theists, Naturalists, Skeptics, And Dualists Toward Science As An Institution, Method, And Application Of Knowledge, Jon Van Wieren

Dissertations

This dissertation is a study of attitudes toward science and stem cell research based on religious worldview. This study examines the relationship through General Social Survey data (2006).

Religious worldview is measured here through some of the most common measures of religiosity. This study differs from many other sociological studies of religiosity in that it includes the view of naturalism alongside other religious worldviews, including theism, dualism, and skepticism. Science is understood and measured here as multidimensional. Comparisons are made between attitudes toward science as a social institution, a research method, and as an application of knowledge - where attitudes …

Real Women? Gender And Race In Prime Time Police Shows, Rondrek Juwayne Cowans

Dissertations

For the past 25 years, reality shows, in particular, police reality shows has figured prominently in American culture as a true representation of police/criminal interactions. This dissertation is a case study that examined the portrayal of African Americans as criminals on the police reality show entitled The Police Women of Cincinnati, Memphis, Dallas, Maricopa County (Phoenix, AZ) and Broward County (Ft. Lauderdale, FL). The cities were chosen because they represent the entire five seasons that the series has been on television. This particular police reality show was also chosen due to its mirror image of local and national television newscasts. …

Equine-Assisted Psychotherapy: A Descriptive Study, Erica Jex Gergely

Dissertations

The current study seeks to examine the program operations and treatment practices of individuals and organizations providing equine-assisted therapy services nationwide. Currently, there are several hundred programs across the United States that utilize equine-assisted therapy to treat common mental health problems in children, adolescents, and adults. Not all equine therapy programs function under the same theoretical model and therefore do not deliver treatment services using equivalent principles or techniques. In addition, program policies, procedures, and ethical guidelines of each provider vary. To date, there exists a paucity of research regarding equine-assisted therapy including both qualitative and quantitative data.

The present …