Digital Commons Network^™

Reconceptualizing Christian Nationalism, Robert Stevenson

Dissertations

This thesis sets out to critically engage with existing research on Christian nationalism. It argues that current research suffers from a methodological focus that is too broad, and theoretical grounding that is too imprecise, both of which prevent researchers from grasping the full scope and intent of Christian nationalism, as imagined by Christian nationalists themselves. Drawing on data collected from X accounts (formerly Twitter) of Christian nationalist users, Christian nationalist podcasts, and Christian nationalist books, it employs qualitative content analysis, mapped to Bourdieusian field theory to provide a structured approach for the understanding complex data involving multiple spheres of power, …

Refining Cross-Population Polygenic Risk Scores Across Diverse Populations, Mansi Patel

Dissertations

Large biobanks containing whole genome sequences connected to the deidentified electronic health records of hundreds of thousands of individuals are increasingly available to researchers. This has facilitated the development of polygenic risk scores (PRS), which use machine learning to predict risk of disease and other phenotypes from millions of genetic variants. Due to Eurocentricity of available genetic data, PRS have primarily been trained in populations of European descent. Differences in allele frequencies, effect sizes, and linkage disequilibrium patterns between populations can limit the transferability of PRS across different populations. Given that most data are from European genetic ancestry populations, we …

The Impact Of Lactobacillus Supplementation On Gut Microbiome Composition And Phage Induction In Mice, Kimia Boreiri

Dissertations

The mammalian gastrointestinal (GI) tract harbors a dense and dynamic community of microbes known as the gut microbiota, which plays vital roles in digestion, immunity, and overall health. Among these, probiotic bacteria such as Lactobacillus strains have garnered attention for their ability to influence microbial community structure and host physiology. This study investigated the effects of five Lactobacillus strains, Lactobacillus casei R1A482, Lactobacillus casei O3, Lactobacillus rhamnosus GG, Lactobacillus gasseri ATCC 33323, and Lactobacillus paragasseri UMB1065, on the gut microbiome of Swiss Webster mice over a six-week feeding period. To reduce stress, mice were fed Lactobacillus strains using gelatin pellets …

Decoding The Origins Of Infection: A Machine Learning Framework, Nirupama G. Shanbhag

Dissertations

Many infections can be attributed to a specific microorganism. For example, while there can be many causes of urinary tract infections (UTIs), such as the bacterial species Klebsiella pneumoniae or Enterococcus sp., the most widespread cause for UTIs is uropathogenic Escherichia coli. Generally, diseases or infections that are the result of a single pathogenic organism are more easily understood. Other diseases, such as irritable bowel disease (IBD), cannot be attributed to one member in the community; rather, it is a result of dysbiosis of the microbial community (microbiota) of the gastrointestinal tract, a combination of an overgrowth of problematic members …

Anti-Inflamatory Mechansim Of Bacillus Subtilis Derirved Exopolysaccharide, Adrian Taylor Ibarra

Dissertations

Exopolysaccharides (EPS) secreted by the commensal bacterium Bacillus subtilis exhibit potent anti-inflammatory properties, yet the underlying molecular mechanisms remain incompletely understood. We hypothesized that EPS reprograms antigen-presenting cells toward a tolerogenic state by modulating TLR4–MyD88 signaling. To test this, we began using a chemically defined, high-yield EPS production and purification protocol that largely eliminates protein and DNA contaminants, thus improving functional reproducibility across experiments using this new method. In vitro, EPS engaged TLR4 on murine dendritic cells (DC2.4) without inducing classical NF-κB activation, seen by LPS stimulation. Rather, EPS treatment upregulated inhibitory molecules, PD-L1 and PD-L2 while leaving activation markers, …

Investigating The Mechanism Of Resistance To Ido1 Enzyme Inhibitor Treatment In Human Glioblastoma, Kyla Shivakumar Hatton

Dissertations

Glioblastoma (GBM) is the most common and most aggressive form of adult cancer in the central nervous system, with GBM accounting for the majority of all malignant brain tumors. GBM is currently considered to be an incurable form of cancer, with over 14,000 patients diagnosed in the United States last year. Given the success of immunotherapy for treating other types of cancer, our group has investigated the possibility of therapeutically neutralizing immunosuppressive indoleamine 2,3 dioxygenase 1 (IDO1) in patients with GBM. Canonically, IDO1 is an immunosuppressive cytoplasmic enzyme that catalyzes the first step in metabolizing L-tryptophan into L-kynurenine (ie. ↓L-Trp→↑L-Kyn). …

Developing Chemically Defined Serum-Free Medium For Leukemic Blast And Stem Cell Expansion, Carmen Eva Finley

Dissertations

The relapse and chemotherapy resistance are the major challenges of acute myeloid leukemia (AML) treatment, driven by a rare population of leukemia stem cells (LSCs). LSCs are unique types of cells which evade standard chemotherapies and can regenerate AML post-treatment. Targeting LSC therapy remains limited, in part due to the lack of reliable in vitro AML culture systems to grow LSCs for drug discovery. This study aimed to engineer a chemically defined, serum-free 2D in vitro culture condition that supports either the expansion of leukemic blasts (LBs) or primary human LSCs by optimizing current protocols for hematopoietic stem cells (HSCs) …

Investigating Whether Txnrd2 Is A Therapeutic Target Against Triple Negative Breast Cancer Using African American-Derived Models, Keacha Chang

Dissertations

Despite similar breast cancer incidence rates, African American (AA) women experience a 40% higher mortality rate compared to Caucasian American (CA) women. This disparity is multifactorial and particularly pronounced in the Chicago area. AA women are twice as likely to be diagnosed with triple-negative breast cancer (TNBC), often at a younger age and with more aggressive disease. TNBC is a heterogeneous subtype lacking targeted therapies and is associated with the poorest prognosis among breast cancer types. Therefore, there is an urgent need for novel therapeutic strategies for TNBC, especially those tailored to AA patients. The thioredoxin pathway is essential for …

Capturing Diverse Adolescents’ Social Contexts: The Development Of An Ethnic-Racial Microaffirmations Scale For Peer Interactions, Maria Radulescu

Dissertations

The development of a strong and positive sense of ethnic-racial identity (ERI) has been identified as an asset for ethnically and racially marginalized adolescents. Peer interactions during the adolescent years can support ERI development. In particular, a subtle micro-level form of peer support—microaffirmations—may be protective for ERI processes. However, the field of microaffirmations is very small, and there is no scale that captures adolescents’ experiences of ethnic-racial microaffirmations from their peers. The current study developed an ethnic-racial peer microaffirmations scale based on extant literature and feedback from 4 focus groups with 22 sophomore high school students. Findings indicated that 5 …

The Bacterial Sensing Nuclear-Oligomerization Domain 2 Receptor In The Brain: Location And Potential Function, Julia Smyth

Dissertations

Nucleotide-binding oligomerization domain-2 (NOD2) is a cytosolic receptor, activated by bacterial peptides that initiates innate immune responses through nuclear factor-κB (NF-κB), mitogen-activated protein kinase (MAPK), and Caspase-1 pathways. While the role of NOD2 in inflammation outside the central nervous system (CNS) is well-established, especially in the gastrointestinal system, its expression and function in the brain remain poorly defined. Previous genetic studies suggest a link between NOD2 and neurological and psychiatric conditions, including stroke, Parkinson’s disease, and schizophrenia. However, information regarding NOD2 expression, localization, and function in the CNS is limited. In this work, we investigated NOD2 expression, localization, and regulation …

"I'M Not Having Fun Anymore": A Qualitative Analysis Of Gender And Harassment In Bars And Clubs, Phoebe Marie Jackson

Dissertations

Sexual harassment, while often spoken about in hushed tones or ignored altogether, happens frequently and often loudly. 66 percent of women who have experienced sexual harassment report that the harassment took place in a public space, such as work, school, or on the street (Kearl, 2018). Harassment is not discreet, but rather normalized, and those who experience it are expected to brush it off or take it in their stride. However, such harassment and subsequent dehumanization has a deteriorating effect on the mental well-being of those affected (Graham et. al., 2016). This study aims to hone in on the effect …

Systematic Review Examining How Black Youth In The United States Cope With Stressful And Traumatic Experiences, Marcus Aaron Flax

Dissertations

Coping is an important behavioral skillset that youth use to emotionally regulate after experiencing stress or trauma. Research has repeatedly highlighted the stressors that Black youth experience, often finding that Black youth face higher levels of stress and trauma than their White peers. However, there has been a lack of research in understanding how Black youth cope with these higher levels of stress. This systematic review includes 72 studies (N = 16,205 participants) examining the frequency and effectiveness of coping strategies used by Black youth in response to a trauma or stressor, along with the associations between utilized coping strategies …

Voices Of Chinese American Emerging Adults: Complex Racial Identities, Family Dynamics, And Mental Health Experiences, Maxwell Lou Xu

Dissertations

Although Asian Americans are the fastest growing racial minority group in the United States, they remain significantly underrepresented in mental health research. Furthermore, research on Asian American mental health often aggregates the experiences of different Asian ethnic groups, creating a limited understanding of how distinct ethnic groups may differ in their mental health experiences. This interview study with Chinese American emerging adults ages 18–25 from varied family contexts (single-race, multiracial, and adoptive households) examines how members of this population make sense of the relationships between their identity, family, and mental health. This thesis posits that Chinese Americans' nuanced experiences—particularly around …

The Forced Sterilization Of Quechua-Speaking Women In Peru: The Role Of Epistemic Injustice In The Perpetration Of Genocide, Geraldine Diaz

Dissertations

The forced sterilization of Quechua-speaking women in Peru from 1996 to 2000 represents a case of genocide in which the state as an epistemic agent has a fundamental role. Although the systematic sterilization was carried out under the guise of a family planning program, the targeting of these women provides strong circumstantial evidence of genocidal intent. According to the testimonies of these women, medical staff, acting on behalf of the government, performed tubal ligation procedures through coercion, threats, lies, bribery, manipulation, and other tactics where the state intentionally withheld information, misinformed women, and failed to obtain proper consent. This research …

In-Person Versus Peer-Coordinated Virtual Health Coaching For Metabolic And Behavioral Outcomes In Women In Sober Living Facilities, Craig R. Witt

Dissertations

Background: Women in early recovery from substance use disorder often face metabolic health vulnerabilities, yet physical health behaviors are frequently under-emphasized in sober living settings. Feasible and accessible wellness strategies are needed to support both behavioral and metabolic health in this population.

Purpose: To compare the effects of professionally delivered in-person health coaching versus peer-coordinated virtual health coaching on metabolic outcomes and health-promoting behaviors among women in sober living facilities.

Methods: In this quasi-experimental study, 32 women enrolled in a 12-week group-based health coaching program focused on nutrition, physical activity, and stress management; 18 completed post-intervention assessments (in-person: n = …

Protein Ingestion And High-Intensity Resistance Training Decrease Respiratory Exchange Ratio Following Exercise In Females Across Various Body Compositions., Lynnsey Bowling

Dissertations

Metabolic dysfunction is associated with excess adipose tissue and interventions to elicit improvements to body composition could combat these health consequences. Acute nutritional and exercise strategies have the potential to shift metabolic processes toward those favoring fat oxidation. The purpose of this study was to investigate the effects of high-intensity resistance training (HIRT) and pre-exercise protein (PRO) ingestion on post-exercise respiratory exchange ratio (RER) in lean (LN) and overweight (OW) females. Twenty recreationally-active females (LN: n =10; OW: n = 10) completed two experimental sessions, consisting of HIRT and two acute nutritional interventions: PRO and placebo (PLA). RER was analyzed …

Astaxanthin Supplementation Does Not Significantly Alter Cognitive Performance Following Mental Fatigue In Females, Gavin A. Barker

Dissertations

Mental fatigue (MF) is a psychobiological state caused by prolonged periods of demanding cognitive activity, often characterized by impairments to cognitive performance. Astaxanthin (AX) is a naturally occurring antioxidant that can cross the blood-brain barrier and may preserve cognition when presented with a MF challenge. As yet, no studies have yet been conducted in an all-female cohort. This is the first study to investigate 4-weeks of AX supplementation on markers of cognitive performance (reaction time (RT), speed, and responses correct per second (RCS), visual analog scale of mental exertion (VAS-E)) following acute MF. Twenty-five recreationally active female subjects (AX: n …

The Impact Of University Engagement On Psychosocial Factors Among Division I Female Student-Athletes, Ashley A. Cook

Dissertations

Background: Female student-athletes navigate unique psychosocial challenges balancing academics and athletics, yet limited research has explored the impact of university engagement on their social and emotional well-being. This study examines the impact of university engagement on sense of social fit (SSF), nonspecific psychological distress (NPD), and loneliness among Division I female student-athletes.

Method: A cross-sectional survey was conducted among female student-athletes (n = 111) from eight sports at a mid-sized NCAA Division I university in the Southern U.S. Participants completed validated measures using the SSF scale, UCLA Loneliness scale, and Kessler-6 Psychological Distress scale. An exploratory factor analysis was performed …

Comparison Of Post-Exercise Lipid Oxidation Rates Between Lower And 1 Upper-Body Resistance Training In Well-Trained Females, Alyssa L. Parten

Dissertations

INTRODUCTION: Lipid oxidation (LOx) is a relevant physiological process linked to metabolic health. Despite growing interest in resistance training (RT) as a means to influence substrate utilization LOx responses in females remain poorly characterized, with no study examining whether lower- and upper body RT elicits different LOx patterns during the recovery period following exercise. This distinction may  be relevant because lower-body exercises involves greater fat-free mass (FFM) and energy expenditure,  whereas upper-body exercises recruit less FFM, potentially influencing metabolic effects.

PURPOSE: To  determine if LOx rates after exercise differ between lower- and upper-body RT in well-trained females.

METHODS: Twenty-two females …

Menstrual Cycle Phase Exerts No Influence On Running Economy Parameters In Recreational Female Runners, Savanna K. Knight

Dissertations

Hormonal fluctuations that occur throughout the menstrual cycle (MC) have been shown to affect substrate utilization and oxygen uptake when running. These MC induced changes could manifest as altered running economy (RE) when expressed as energy cost (Ec) and oxygen cost (O2c). Therefore, the current study aimed to determine if RE differs between MC phases, the early follicular phase (E-FP) and the mid-luteal phase (M-LP). Twelve eumenorrheic female recreational runners (ages 25 ± 4y; VO2peak 40.9±4.6 ml/kg/min) completed submaximal RE bouts (60%, 70%, 80% of VO2peak) during the E-FP and M-LP. During each bout, oxygen consumption (VO2), respiratory exchange ratio …

Self-Awareness And Self-Efficacy In The Novice Professional Phase Of Marriage And Family Therapists After Person Of The Therapist Training, A Comparative Survey, Rubio Betsabé

Dissertations

The study focuses on examining the influence of person-of-the-therapist or self-of-the-therapist training on therapists’ self-reports of self-awareness (as a conscious awareness of one’s internal states and interactions with others) and self-efficacy (perceived beliefs in personal capabilities to perform in ways that give control over events that affect their lives) at the novice professional stage of their career. The study will examine the experiences reported by mental health providers actively providing clinical care by utilizing a survey design focusing on person of the therapist connecting through alumni lists and online solicitation. This research adds to the current literature by using a …

What Works In Telehealth Play Therapy? An Appreciative Heuristic Inquiry, Veronica Ann Ball

Dissertations

With the onset of coronavirus disease 2019 (COVID-19) in the United States in March 2020 (World Health Organization, 2020), professional counselors providing traditional in-person play therapy found themselves in a quandary regarding the delivery of services during a global pandemic (Evans, 2022; Mitchell, 2020; Whaibeh et al., 2020). Online counseling proffered a means to prevent the disruption of services, respond to the need for emerging counseling services, and comply with social restrictions (Evans, 2022). Prior to the pandemic, telehealth play therapy was used sparingly (Haslam & Harris, 2011; Smith et al., 2021), and many child-serving mental health professionals lacked training …

What About The Children? An Exploration Of Family Counselors' Play Therapy Training And Preparedness To Integrate Children Into Family Counseling, Patricia J. Walker Monical

Dissertations

Children are an important part of families, yet family counselor education programs often do not incorporate training for including children in family counseling. At some point in their careers, family counselors and therapists will encounter clients who have children 3–12 years old. The problem is that since these professionals often receive little to no training in play therapy and thus do not typically include young children in family therapy, these younger family members are often overlooked. Research has confirmed that, due to a lack of sufficient training and supervision in play therapy, many family therapists report feeling unprepared to work …

Becoming A Leader “On The Job”: An Exploratory Study Examining How Internal Interim Leaders Build Their Leadership Capacity While Nonprofit Executive Directors Are On Sabbatical, Michelle Schneider

Dissertations

Nonprofit organizations have long underinvested in leadership development, potentially hindering their ability to fulfill their missions effectively. This study examined the use of nonprofit organization sabbaticals that give executive directors time away while building the leadership capabilities of the interim leader. This research explored the on-the-job leadership development of six individuals who served as interim leaders in southern California nonprofit organizations during their executive directors' participation in a 3-month, foundation-funded sabbatical program.

In this study, data were collected through in-depth interviews with interim leaders. A formative influences timeline technique was employed to center the participant's voice rather than the interviewer's …

Learning Paradigms For Rhythm Detection And Generation Using Mathematical Models, Biophysical And Artificial Neural Networks, Prianka Bose

Dissertations

Humans possess an inherent ability to recognize evenly-spaced rhythms, known as isochronous rhythms, owing to the brain's predisposition to entrain to external auditory stimuli with regular temporal intervals. The central focus of this research is to understand how the brain learns and retains rhythmic time intervals in the context of music. This dissertation studies rhythm detection and generation through mathematical models, biophysical networks, and artificial neural networks, addressing both isochronous and non-isochronous patterns.

A primary focus of the thesis is on isochronous rhythms. In particular, given a perturbation to an isochronous rhythm such as a tempo change or phase shift …

Machine Learning Methods For Pattern Recognition Analysis Of Genomic And Molecular Data, Kuang Du

Dissertations

While immune therapies achieve remarkable success in treating various cancers, only a subset of patients achieves a durable clinical response, and many exhibit innate or acquired resistance. Precision medicine aims to tailor treatments to individual patients based on specific biological markers, ensuring that each patient receives the therapy most likely to be effective. Predictive biomarkers and gene signatures offer potential for more personalized treatment strategies by identifying patients likely to benefit. Recent studies suggest that gene signatures, comprising sets of genes, hold predictive value for certain clinical variables. Typically derived from biological expert knowledge, these signatures demonstrate substantial predictive potential, …

Interactive Visualization Workflows For Mitigating Analytical Uncertainty, Kaustav Bhattacharjee

Dissertations

This dissertation takes a process-centric and stakeholder-first perspective for handling analytical uncertainty: the form of uncertainty that confronts data analysts' insight-generation processes in high-consequence decision-making scenarios. The cost of an incorrect decision when data is used for movie recommendations as opposed to when personal data is used to drive insights or when data-driven modeling is used to drive real-time decisions for maintaining the health of a grid are vastly different in terms of consequences. This dissertation looks at analytical uncertainty in two real-world scenarios: i) how sensitive information leakage can be prevented during the open data release process with data …

Representation Of Alaskan Native People In Nonprofit Leadership, Vanessa Smith

Dissertations

The nonprofit sector faces a significant issue: the underrepresentation of the communities it aims to serve, including Alaska Native communities. This research investigates the likely causes of this underrepresentation and explores potential solutions. It includes nine qualitative interviews with a majority of Alaskan Native leaders and consultations with other non-Native nonprofit leaders who have extensive experience in Alaska's nonprofit organizations.

This study arose from firsthand experience in an Anchorage, Alaska nonprofit, where the lack of Alaska Native representation in leadership roles within an organization meant to serve the Alaska Native community was evident. The research aimed to understand how well …

Rethinking Safe Nurse Staffing In The Post-Covid Icu: A Comparative Analysis Of The Nurse-To-Patient Ratio And Mixed Model Approach For State Policies, Emilie A. Maxie

Dissertations

The coronavirus pandemic (COVID-19) led to an unprecedented surge in ICU admission, increasing the nurse-to-patient ratios and intensifying stress on ICU nurses. This prompted many nurses to leave bedside care, exacerbating the ongoing nursing shortage and creating unsafe working conditions. Fourteen states have enacted safe nurse staffing policies. California implemented a mandated nurse-to-patient ratio, while Massachusetts adopted a mixed model for ICUs that involves a ratio, nurse committees, and workload tools. In post-COVID, this raises the question of which state policy approach is more effective in retaining ICU nursing staff. Literature suggests a mixed policy may be more effective.

A Phenomenological Study To Determine How Expert Avid Teachers Use Collaboration To Strengthen Student Metacognition And Student Self-Efficacy And Determine When It Occurs, Megan Hernandez

Dissertations

Purpose: The purpose of this phenomenological study was to determine how expert AVID teachers from the California Central Valley describe the use of collaboration to strengthen student metacognition and self-efficacy and how they describe the evidence that indicates metacognition and self-efficacy are occurring.

Methodology: Five Central California school districts were chosen to conduct the phenomenological study on expert AVID teachers. One to two AVID teachers from each of the five school districts were chosen in the study for eight participants. The expert AVID teachers were chosen for having at least five years of experience teaching AVID and being up to …