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Neuroprotective Effects Of A Nicotinic Acetylcholine Receptor Agonist And Modulator In The Rodent Retina, Kazuhiro Iwamoto

Dissertations

The purpose of this dissertation is to assess the potential neuroprotective effect of an alpha7 nAChR agonist, PNU-282987, and modulator, PNU-120596, in an in vitro model of excitotoxicity and an in vivo model of acute glaucoma. In in vitro studies, retinas obtained from Long Evans rats were cultured using various concentrations of the PNU compounds to analyze neuroprotection against glutamate-induced excitotoxicity. After 3 days in culture, RGCs were identified using an antibody against Thy 1.1, visualized using a fluorescent dye and quantified. In culture, glutamate significantly decreased the number of RGCs. However, if either PNU compound was introduced before the …

Psychometric Properties Of Diagnostic Assessment Instrumentsfor Autism Spectrum Disorders In A Community Sample Aged 2 Through 17 Years, Sheryl Lozowski-Sullivan

Dissertations

Recent estimates of the incidence and prevalence of autism spectrum disorders (ASDs) indicate substantial increases over the past 20 years (Centers for Disease Control and Prevention, 2009; Fombonne, 2009; Matson & Kozlowski, 2011; Schreibman & Koegel, 2005; Wing & Porter, 2002), in part because of the availability of significantly improved diagnostic assessment instruments (Lord & Corsello, 2005; Schreibman, 2005). In highly structured research settings, some of these diagnostic instruments correlate well with each other; however, few studies have examined the relation between these diagnostic tools in traditional clinical practice (Mazefsky & Oswald, 2006; South et al, 2002). This study examined …

Dosed Versus Prolonged Exposures: A Direct Comparison Of One-Session Treatments For Animal Phobias, Richard William Seim

Dissertations

It is widely accepted that for exposure-based therapies to be effective feareliciting stimuli must be presented continuously until there is a marked decrease in the client's anxiety (e.g., Eysenck, 1979; Foa & Kozak, 1986). However, an emerging body of research (cf. Seim, Waller, & Spates, 2010) suggests that a massed series of very brief exposures (< 150 sec) may be effective in the extinction of fear responses. The present study was designed to compare the efficacy and acceptability of two one-session treatments for animal phobias: one that utilized continuous, uninterrupted periods of exposure to a feared animal (Prolonged Exposures) and the other that utilized a massed series of brief (5-120 sec) exposure trials (Dosed Exposures). 24 adults (7 males, 17 females) between the ages of 18 and 57 years (M = 23.6) participated in this study. Each individual met DSM-IV criteria for a diagnosis of snake phobia or spider phobia. Participants were randomly assigned to one of two the two interventions. Both treatments required participants to gradually enter a room, approach, and eventually hold a live ball python or tarantula. Results from mixed model (between x within subjects) analyses of variance showed that the Dosed Exposure treatment performed equally well to Prolonged Exposures at decreasing behavioral avoidance, feelings of anxiety, perceptions of threat, and phobiaspecific cognitions from pre-treatment to post-treatment, and these gains were maintained at one-week follow-up. Although participants receiving Prolonged Exposures reported lower ratings of within-session anxiety, participants in the Dosed Exposure group had lower rates of treatment dropout, better compliance with procedures, and fewer safety-seeking behaviors during the treatment. These findings suggest that, contrary to popular belief, brief exposure trials can be effective in the extinction of phobic responses under certain conditions.

Characterizing Potential Sustainable Energy Feedstocks, Jesse George Thompson

Dissertations

Trap grease offers a promising and less expensive alternative to food grade vegetable oils for biodiesel production, but its commercial marketability could be affected by its intense and offensive odor. Identification, quantitation and eventual elimination of the odorant compounds are vital challenges that need to be addressed before commercialization can be achieved. A rapid method using HS-SPME and GC/MS was developed in this study to identify and quantify the major volatile odorant compounds present in trap grease. The main odorant compounds were identified as short chain free fatty acids (SC-FFA) from C₄ - C₁₀.

Sensory evaluations by …

Glucosamine-Induced Insulin Resistance In Primary Rat Hepatocytes And The Role Of Selenium As An Insulin Mimetic, Sandhya N. Adiyodi Veetil

Dissertations

Type 2 diabetes is mediated by insulin resistance, the inability of insulin to elicit a normal biological response in insulin responsive tissues. Several cellular models have been utilized to determine the mechanism of induction of insulin resistance but questions remain unanswered. One model, implicates the products of the Hexosamine Biosynthetic Pathway (HBP) in the induction of insulin resistance under hyperglycemia. The major end product of HBP, UDP-GlcNAc, is the substrate for O-GlcNAc transferase, an enzyme that catalyzes the O-GlcNAcylation of numerous proteins. This modification may play a role in induction of insulin resistance and thus needs to be evaluated in …

Isolation And Characterization Of Compounds From Zanthoxylum Setulosum In The Development Of Novel Structures For Chemotherapeutic Drugs, Tameka M. Walker

Dissertations

No abstract provided.

Modeling, Comparison And Analysis Of Multi Body Parafoil Models With Varying Degrees Of Freedom, Chrystine M. Gorman

Dissertations

No abstract provided.

Sprite Generation Using Sprite Fusion, Yi Chen

Dissertations

No abstract provided.

A Case Study Of How Students Enrolled In Cte Programs And Faculty Understand And Assess The Implications Of Globalization On Career Preparation, Mohammad A. Moradi

Dissertations

Globalization reflects a shift in the workforce development paradigm. This descriptive qualitative case study was conducted at a Midwestern university with 12 student participants and three faculty members from three engineering programs. The purpose of this body of work was to explore the participants‘ perceptions of globalization, and to understand the implications of globalization on career and technical education (CTE) programs, program selection, and career choices, the training of the students enrolled in CTE programs, and the role of teaching faculty and the college in this process.

How CTE programs aligned many diverse programs to meet a growing demand for …

Natural Product Inhibitors Of Rhodesain : The Major Cysteine Protease Of Trypanosoma Brucei, Ifedayo Victor Ogungbe

Dissertations

No abstract provided.

Dynamic Generation Of Reduced Ontologies To Support Resource Constraints Of Mobile Devices, Dan Schrimpsher

Dissertations

No abstract provided.

Fragment Based Lead Discovery Of Inhibitors Of Urokinase Type Plasminogen Activator, Li Qiu

Dissertations

No abstract provided.

An Analog Experiment Comparing Goal-Free Evaluation And Goal Achievement Evaluation Utility, Brandon W. Youker

Dissertations

Goal-free evaluation (GFE) is the process of determining the merit of an evaluand independent of the stated or implied goals and objectives, whereas goal achievement evaluation (GAE), as the most rudimentary form of goal-based evaluation, determines merit according to the evaluand’s level of accomplishment with regard to its goals. This study examines the utility of GAE and GFE from the perspective of the evaluation’s intended users. In the study, two evaluation teams, goal achievement and goal-free, independently and simultaneously evaluate the same human service program. Each team produced a final evaluation report, which was read by the evaluation’s users, who …

Alternations In The Splenic Marginal Zone With Age, Shirin Z. Birjandi

Dissertations

Splenic marginal zones are architecturally organized to generate a rapid response against blood- borne antigens entering the spleen. The marginal zone is a distinct anatomical micro-environment whose main components include the marginal zone macrophages, the marginal zone B cells, the marginal zone sinus, and the metallophilic macrophages. Marginal zone macrophages, in partnership with marginal zone B cells, are particularly important in host defense against T-independent pathogens and are crucial for the prevention of diseases such as Streptococcus pneumonia. It has been widely reported that with the advancement of age there is a higher rate of mortality as a result of …

The Seduction Of Feminist Theory, Erin Amann Holliday-Karre

Dissertations

My dissertation, "The Seduction of Feminist Theory," comes out of my research on South African fiction and the Truth and Reconciliation Commission, and focuses broadly on feminist theory and the question of female power. Traditionally feminist theory has sought to empower women by insisting on their equality to men and by allowing their voices to be heard. But in trying to understand why women did not speak about their personal victimization at the TRC hearings, and why so many women characters in South African fiction are unable or unwilling to speak, I have come to see that women do not …

The Role Of Nogo-A In Memory And Neuronal Plasticity In The Aged Rodent Brain, Rebecca Lynn Gillani

Dissertations

The long-term effects of stroke often include cognitive impairments, but other than cognitive rehabilitation, which is often not fully successful, there is no intervention to treat cognitive impairments in stroke survivors. Our laboratory has previously shown that immunotherapy directed against the Nogo-A protein, which is enriched on oligodendrocytes, improves recovery of skilled forelimb sensorimotor function in adult and aged rats after an ischemic stroke lesion to the sensorimotor cortex. Furthermore, this recovery was correlated with axonal sprouting from intact pathways to denervated areas, as well as dendritic sprouting and increased dendritic spine density in the contralateral sensorimotor cortex. In the …

Effects Of Neuronal Nogo-A On Properties Of Excitatory Synapses Of The Sensorimotor Cortex, Alicia Marie Case

Dissertations

Recovery after central nervous system (CNS) injury has long been a challenge for clinical investigators. Blockade of the oligodendrocyte-associated inhibitor Nogo-A has shown great promise in promoting neuronal regeneration, sprouting, and plasticity, as well as functional recovery in rodent and primate models of CNS injury. The high expression of Nogo-A in neurons of the postnatal CNS led us to look for potential roles of this protein in this stage of development. We hypothesized that postnatal, neuronal NogoA influences the density and morphology of dendritic spines in the developing CNS, in part, by regulating the maturation and stability of glutamatergic synaptic …

Effects Of Electrical Stimulation And Testosterone In Translational Models Of Facial Nerve Injury, Nijee Sharma

Dissertations

Among the various peripheral nervous system injuries seen clinically, facial nerve lesions are prevalent and have significant functional and emotional impact on patients. As injuries can occur in different segments of the facial nerve and lead to different pathophysiological outcomes, animal models that mimic the common sites of injury need to be developed so that potential therapies can be appropriately investigated. The extratemporal facial nerve axotomy model, in which the nerve is crushed at its exit from the skull, has been well established in the past and used to study the regeneration program of motoneurons. The present study uses this …

Restoring The Balance: Setting Aside Naturalism In Favor Of Personhood In Extreme Cases, Brian Joseph Buckley

Dissertations

This dissertation addresses a simple question: Is an anencephalic child a person? These children are born with only a brain stem, and, as such, cannot experience any type of consciousness. If personhood is understood as an articulable moral category, particularly distinct from DNA membership, reasonable evidence would be required to attribute any such moral category in these cases. That is, to claim that children who may never think or feel are persons carries a philosophical burden that extends beyond mere Homo Sapiens membership. This dissertation accepts that burden and answers that anencephalic children are persons. To do this, I first …

Expression And Regulation Of Osteopontin In The Diabetic Heart, Abigail Goodman

Dissertations

Diabetes leads to several alterations in cardiac structure, one of which is fibrosis of the ventricular myocardium. Myocardial fibrosis is a common underlying factor in most cardiac pathologies. Osteopontin (OPN) is a small phospho-protein that has been implicated in fibrotic tissue remodeling. In the heart, the expression of OPN protein is increased after acute and chronic pathologies. Upregulation of OPN coincides with a transition to heart failure and a direct role for OPN in the progression of diabetic cardiomyopathy to heart failure has been reported.

The overall objective of this project is to determine if OPN is upregulated in the …

Religion, Science, And The Conscious Self: Bio-Psychological Explanation And The Debate Between Dualism And Naturalism, Paul J. Voelker

Dissertations

This dissertation approaches metaphysical and metaethical questions concerning the nature of the human person, the existence and nature of God, and the nature of moral judgment through contemporary neuroscience, cognitive science, scientific moral psychology, and analytic philosophy of mind. Contrary to proposals that seek a harmonious integration of "religion and science" this dissertation argues that contemporary bio-psychological sciences give one ample reason to be skeptical of many of the metaphysical and metaethical claims embedded in religious traditions like Christianity and Buddhism. The first three chapters of the dissertation focus on the metaphysical issue of mind-body dualism while the fourth chapter …

A Systematic Review And Meta-Analysis Of The Effectiveness Of Child-Parent Interventions For Children And Adolescents With Anxiety Disorders, Kristen Brendel

Dissertations

Anxiety disorders are the most prevalent psychiatric disorders in childhood (Walkup & Ginsburg, 2002; Hirshfeld-Becker & Biederman, 2002), occuring in approximately twenty percent of the population (APA, 2000; Langley Lindsey, Bergaman & Piacentini, 2002). Children and adolescents with anxiety disorders often experience many detrimental effects such as low-self esteem, issues with social and family relationships, and a decrease in overall functioning, including academic performance. In addition, if left untreated or unrecognized, anxiety disorders in childhood often lead to more severe symptoms in adulthood including depression, substance abuse, suicidal ideation, and other comorbid anxiety disorders. Evidence suggests that anxiety disorders are …

The Synthesis And Host-Guest Applications Of Synthetic Receptor Molecules, Zachary Richard Osner

Dissertations

Host-guest chemistry involves the complimentary binding between two molecules. Host molecules have been synthesized to bind negative, positive, and neutral molecules such as proteins and enzymes, and have been used as optical sensors, electrochemical sensors, supramolecular catalysts, and in the pharmaceutical industry as anti-cancer agents.1 The field of nanoscience has exploited guest-host interactions to create optical sensors with colloidal gold and Dip-Pen nanolithography technologies. Gold nanoparticles, have been functionalized with DNA, and have been developed as a selective colorimetric detection system, that upon binding turns the solution from a red to blue in color.2

Cyclotriveratrylene (CTV) 1 is a common …

Response To Violent Prone Female Adolescents: The Chicago Public School Approach, Marian E. Dozier

Dissertations

School violence has become increasingly more prevalent among adolescent females over the last ten years. As administrators, teachers, parents, and law enforcement officials try to control and decrease the number of violent incidents that occur in our schools, adolescent females continue to exhibit inappropriate and violent behavior at an alarming rate within our school communities. Adolescent females who behave badly have historically been overlooked or ignored, as girls have often been perceived as being incapable of demonstrating hostile conduct in an academic setting.

The purpose of this study was to investigate, describe, and analyze the frequency and nature of violent …

The Relationship Between Transformational Leadership And The Emotional And Social Competence Of The School Leader, David Saxe

Dissertations

Sustainable school reform efforts are needed to move schools closer toward the ideals of equity, justice and success for every student. The success or failure of a school and its students often hinges on the effectiveness of leadership. Research reveals that transformational school leaders become effective change agents by developing a shared vision for the school, building consensus around key priorities, holding high expectations, providing support, modeling appropriate values and building collaborative cultures and shared leadership. The purpose of this study is to examine the predictive relationship between the emotional and social competence and transformational leadership behaviors of school principals. …

Comics And Conflict: War And Patriotically Themed Comics In American Cultural History From World War Ii Through The Iraq War, Cord A. Scott

Dissertations

Illustration has been an integral part of human history. Particularly before the advent of media such as photography, film, television, and now the Internet, illustrations in all their variety have been the primary visual way to convey history. The comic book, which emerged in its modern form in the 1930s, was another form of visual entertainment that gave readers, especially children, a form of escape.

As World War II began, however, comic books became an integral part of war propaganda as well providing information and education for both children and adults. This dissertation looks at how specific comic books of …

Abstention To Consumption: The Development Of American Vegetarianism, 1817-1917, Adam Daniel Shprintzen

Dissertations

The history of vegetarianism in the United States has long been shrouded in myth, assumption and obfuscation. Vegetarianism as a vital ideological and political movement has often been presented--even by its proponents--as a product of twentieth century modernism, reflecting a rise in ethical consumer awareness. The historical record of the nineteenth century, however, tells a very different story. The notion that dietary choices could be connected with larger social and political goals was formulated during, and changed dramatically in the nineteenth century. This dissertation charts the rise and evolution of vegetarianism in the United States from 1817 until 1917.

This …

Beyond The American Dream : Tales Of Hispanic Mutimillionaires Who Rose Above Poverty After Immigrating To The United States, Ricardo Norton

Dissertations

Problem. A review of the literature on Hispanics reveals the absence of academic studies on the conditions and life experiences that helped poor Hispanic immigrants become multimillionaires after arriving to the U.S. at 18 years of age and older and without conversational English. Most Hispanic immigrants live in poverty right after arriving to the U.S. and only a few become multimillionaires. A study on how they rose above poverty has the potential to uncovering useful information for other poor immigrants who are still looking who seek financial success. Such study will also add to the larger body of literature information …

Biblical Sources In The Development Of The Concept Of The Soul In The Writings Of The Fathers Of The Early Christian Church, 100-325 C.E., Thomas W. Toews

Dissertations

The topic of the human soul has seen renewed interest in recent years. Studies have been produced that have looked at the soul in light of modern science and medicine along with a continued focus on the thoughts of the ancients on this topic. The early Church Fathers played an important role in mediating the thoughts of the ancients to more recent times. Because of this role, it is important to understand what function the Scriptures had as a source of authority in this process.

In light of this, the following study researches and analyzes the usage of the two …

A Comparative Analysis Of The Origin And Divine Causation Of Death In Ancient Near Eastern Literature And In The Old Testament, Lazarus Castang

Dissertations

The present dissertation attempts a comparative analysis of both the origin of death in the creation accounts and the divine causation of death in the main flood accounts in the ancient Near Eastern (ANE) literature and the Hebrew Old Testament (OT). Both literatures are examined for their implicit or explicit conceptions of the origin and divine causation of death. The origin of death in the ANE literature is located in the Egyptian Osirian myth and the Mesopotamian Enki-Ninmah myth, Enûma Elish, Epic of Gilgamesh, and the Adapa legend. The divine causation of death is studied in the Eridu Genesis, Atra-Hasis …