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Computational Design Of Levansucrase For Production Of Tailor-Made Length Levan-Type Fructo-Oligosaccharides, Pongsakorn Kanjanatanin
Computational Design Of Levansucrase For Production Of Tailor-Made Length Levan-Type Fructo-Oligosaccharides, Pongsakorn Kanjanatanin
Chulalongkorn University Theses and Dissertations (Chula ETD)
Levansucrase (LS) is an exocellular fructosyltransferase catalyzing the hydrolysis of sucrose and polymerization of levan and levan-type fructo-oligosaccharides (LFOs) that have various potentials in pharmaceutical and biological applications such as prebiotics and anticancer agents. LFOs with the chain length of 5 (LFO5 or GF4) showed inhibition activity against the SW480 colorectal cell lines up to about 83%. Although LFO5 has beneficial properties, the ability to produce LFO5 in large quantity is still limited. This study aimed to explore conformational diversity and elucidate the structural and molecular properties of LFO5, LFO10 and LFO15 as well as to redesign the active site …
Evaluation Of Photosynthesis Process Under Drought-Stress Condition Of Chromosome Segment Substitution Line Populations With ‘Khao Dawk Mali 105’ Rice Genetic Background For Drought-Responsive Gene Identification And Characterization, Kansinee Hungsaprug
Chulalongkorn University Theses and Dissertations (Chula ETD)
This research aims to evaluate the photosynthesis-related parameters in chromosome segment substitution lines (CSSL), containing drought tolerant region from DH212 in a ‘KDML105’ genetic background. Screening at seedling stage indicated that CSSL4 was more tolerant to drought stress than ‘KDML105’ with the higher maximum quantum yield of Photosystem II (Fv/Fm). At vegetative stage, CSSL4 tended to have the higher level of light-saturated net photosynthetic rate (PNmax), stomatal conductance (gs), electron transport rate (ETR) and effective quantum yield of photosystem II photochemistry (FPSII), when compared to the ‘KDML105’ after 9 days of water withholding. Moreover, the flag leaves of CSSL4 and …
ฤทธิ์ของน้ำคะน้าจีนในการยับยั้งการเจริญของเซลล์ และเหนี่ยวนำการตายแบบอะพอพโทซิสในเซลล์มะเร็งเม็ดเลือดขาวเพาะเลี้ยงผ่านการเพิ่มการแสดงออกโปรตีนแคสเปส 3, ศิริพร พึ่งพวก
Chulalongkorn University Theses and Dissertations (Chula ETD)
ผักคะน้าจีนถูกนิยมนำมาใช้เป็นส่วนผสมในอาหารเอเชียตะวันออก ผักชนิดนี้จัดอยู่ในตระกูลกะหล่ำ ซึ่งผักในตระกูลนี้มีองค์ประกอบของสารต่อต้านอนุมูลอิสระสูง โดยเฉพาะอย่างยิ่งสารกลุ่มกลูโคซิโนเลตและไอโซไธโอซัยยาเนตซึ่งเป็นสารที่พบเฉพาะในผักตระกูลกะหล่ำ การศึกษาจำนวนมากแสดงให้เห็นว่าสารสกัดจากพืชตระกูลกะหล่ำมีฤทธิ์ต้านมะเร็ง อย่างไรก็ตามผู้คนส่วนใหญ่นิยมรับประทานผักคะน้าจีนด้วยการปรุงสุก โดยในงานวิจัยนี้มีวัตถุประสงค์เพื่อประเมินฤทธิ์ของน้ำผักคะน้าจีนต่ออัตราการมีชีวิตรอดและการเพิ่มจำนวนของเซลล์เม็ดเลือดขาว เซลล์ U937 ถูกเลี้ยงด้วยน้ำผักคะน้าแบบจีนแบบสดและที่ผ่านความร้อน ซึ่งถูกเตรียมโดยวิธีการนึ่ง (0.625, 1.25, 2.5 และ 5 %v/v) เพื่อเปรียบเทียบฤทธิ์ในการต้านมะเร็ง อัตราการมีชีวิตรอดมีชีวิตและการเพิ่มจำนวนของเซลล์ถูกทดสอบด้วยการใช้สีย้อมและวิธี XTT ที่ 24, 48 และ 72 ชั่วโมง ผลการวิจัยพบว่าที่ 72 ชม. การบ่มด้วยน้ำผักคะน้าจีนสด 5 %v/v ลดอัตราการมีชีวิตรอดของเซลล์ถึง 13 ± 11.9 % ในขณะที่การรักษาด้วยน้ำผักคะน้าจีนที่ผ่านความร้อน 5 %v/v ลดอัตราการมีชีวิตรอดของเซลล์ได้ 49 ± 8.3 % จำนวนเซลล์และการทดสอบ XTT แสดงให้เห็นว่าน้ำผักคะน้าจีนทั้งแบบสดและที่ผ่านความร้อนสามารถลดการเพิ่มจำนวนเซลล์ได้ตามระดับความเข้มข้นและเวลา วัฏจักรของเซลล์และการตายของเซลล์ที่เลี้ยงร่วมกับน้ำผักคะน้าจีนถูกวิเคราะห์โดยโฟลซัยโตมิตรี พบว่ามีประชากรของเซลล์เพิ่มขึ้นที่ระยะ sub G1 และเซลล์มีการตายแบบ apoptosis เพิ่มขึ้น โดยเฉพาะอย่างยิ่งที่ความเข้มข้นสูงและระยะเวลาที่มากขึ้น เมื่อเปรียบเทียบกับตัวควบคุม นอกจากนี้การวิเคราะห์ด้วยวิธี Western blot แสดงให้เห็นว่าการเกิดอะพอพโตซิสที่ถูกเหนี่ยวนำโดยน้ำผักคะน้าจีนนั้นเกี่ยวข้องกับการเพิ่มขึ้นของโปรตีน caspase 3 โดยรวมแล้วผลการวิจัยพบว่าน้ำผักคะน้าจีนสดมีประสิทธิภาพมากกว่าน้ำผักคะน้าจีนที่ผ่านความร้อนในการต้านมะเร็งเม็ดเลือดขาว อย่างไรก็ตามผักคะน้าจีนทั้งสองรูปแบบถูกใช้เป็นอาหารเสริมที่มีฤทธิ์ต้านมะเร็งเม็ดเลือดขาวได้
Health Consciousness And The Theory Of Planned Behavior: The Role Of Health Consciousness With The On-Campus Use Of Reusable Water Bottle Among Chulalongkorn Freshmen, Aruch Patumtaewapibal
Health Consciousness And The Theory Of Planned Behavior: The Role Of Health Consciousness With The On-Campus Use Of Reusable Water Bottle Among Chulalongkorn Freshmen, Aruch Patumtaewapibal
Chulalongkorn University Theses and Dissertations (Chula ETD)
Use of reusable water container on Chulalongkorn University campus, though is pro-environmental, is currently limited among the students. The present study investigated antecedents of such behavior, using the theory of planned behavior (TPB) with health consciousness as an addition to the model. One-hundred and twenty Chulalongkorn freshmen filled out a TPB-based questionnaire with a health consciousness scale. Data analyses using LISREL reveal an excellent fit for the TPB model. Specifically, attitude, perceived norms, and perceived behavioral control significantly and positively predicted intention and the behavior. Health consciousness indirectly influence intention and behavior via attitude, perceived norms, and perceived behavioral control. …
“Krue Seumangat; Kehamilan Sehat Tanpa Anemia” Booklet Effect To Anemia Among Pregnant Women At Kota Langsa Indonesia : A Quasi Experimental Study, Putri Nahrisah
Chulalongkorn University Theses and Dissertations (Chula ETD)
Purpose : To assess the effect of education interventional program by previously developing ane education material (booklet of anemia and supplement reminder) upgrade dietary and iron-folic acid te intake of anemic pregnant women in province Aceh. Patients and methods: It was quasi experimental study using a pre- and posttest design, purposively applied at two municipalities having more than 40% anemic pregnancy. The intervention group (n=70) received two home visits for individual counseling session and was given the paper-based reminder, the control group (n=70) followed the usual antenatal care. The knowledge regard anemia and nutritional anemia score, average daily iron intake …
Determination Of Sugar In Non-Alcoholic Beverages Using Near Infrared Spectroscopy Combined With Chemometrics, Sureerat Makmuang
Determination Of Sugar In Non-Alcoholic Beverages Using Near Infrared Spectroscopy Combined With Chemometrics, Sureerat Makmuang
Chulalongkorn University Theses and Dissertations (Chula ETD)
The measurement of Near infrared (NIR) spectroscopy, combined with chemometric techniques, has been widely employed for quality control in food products. This study presents a methodology to optimize the calibration models, called "universal model" of NIR spectra of primary condition (glucose solutions) and maintain the accurate prediction of secondary conditions. For instance, the models were designed for determination of glucose concentration in non-alcoholic drinks. Three stages of methodology including pre-processing, feature selection and main component extraction were applied to spectral data in order to obtain the universal calibration model. The simulated NIR spectra with different noise levels were used to …
การพัฒนาอุปกรณ์วิเคราะห์ฐานกระดาษสำหรับหาปริมาณสารเพรดนิโซโลนและเดกซาเมทาโซนที่ปลอมปนในผลิตภัณฑ์สมุนไพรด้วยวิธีเคมีไฟฟ้า, วิศรุต พริ้มพราย
การพัฒนาอุปกรณ์วิเคราะห์ฐานกระดาษสำหรับหาปริมาณสารเพรดนิโซโลนและเดกซาเมทาโซนที่ปลอมปนในผลิตภัณฑ์สมุนไพรด้วยวิธีเคมีไฟฟ้า, วิศรุต พริ้มพราย
Chulalongkorn University Theses and Dissertations (Chula ETD)
การปลอมปนของสารสเตียรอยด์ชนิดเดกซาเมทาโซนและเพรดนิโซโลนในผลิตภัณฑ์สมุนไพรเป็นปัญหาสำคัญที่ก่อผลเสียร้ายแรงต่อสุขภาพของผู้ใช้ ในหลาย ๆ ประเทศทั่วโลก โดยเฉพาะอย่างยิ่งในประเทศกำลังพัฒนา งานวิจัยนี้ ประสบความสำเร็จในการพัฒนาอุปกรณ์สำหรับแยกและตรวจวัดปริมาณการปลอมปนของสารสเตียรอยด์ดังกล่าว โดยใช้อุปกรณ์ตรวจวิเคราะห์ฐานกระดาษและใช้หลักการทางเคมีไฟฟ้า (electrochemical paper-based analytical device หรือ ePAD) ซึ่งประกอบด้วยกระดาษ Whatman SG81 ตลับพลาสติกจากการพิมพ์สามมิติ และขั้วไฟฟ้าชนิด screen printed electrode โดยกระดาษ Whatman SG81 ใช้สำหรับแยกสารสเตียรอยด์ชนิดเดกซาเมทาโซนและเพรดนิโซโลน โดยใช้วัฏภาคเคลื่อนที่เป็นสารละลาย 60% ethyl acetate ใน cyclohexane ซึ่งผลการศึกษาพบว่าสามารถแยกสารสเตียรอยด์ดังกล่าวออกจากสิ่งเจือปนต่าง ๆ ได้ภายใน 7 นาที สารสเตียรอยด์ที่แยกออกจากกันบนกระดาษ นำมาวัดปริมาณด้วยเทคนิคเคมีไฟฟ้าชนิด differential pulse voltammetry โดยใช้ตลับพลาสติกจากการพิมพ์สามมิติที่ถูกออกแบบทำให้สารละลายอิเล็กโทรไลต์ถูกขังอยู่บนกระดาษ ทำให้สามารถตรวจวัดสัญญาณทางเคมีไฟฟ้าได้คงที่ ซึ่งอุปกรณ์ที่พัฒนาขึ้นสามารถตรวจวัดปริมาณปลอมปนของสารสเตียรอยด์ทั้งชนิดเดกซาเมทาโซนและ เพรดนิโซโลนได้ในช่วงความเข้มข้นระหว่าง 10 ถึง 500 µg/mL โดยมีค่าสัมประสิทธิ์สหสัมพันธ์เท่ากับ 0.988 และ 0.994 ตามลำดับ มีขีดจำกัดในการตรวจวิเคราะห์เชิงคุณภาพเท่ากับ 3.59 µg/mL และ 6.00 µg/mL ตามลำดับ และขีดจำกัดในการตรวจวิเคราะห์เชิงปริมาณมีค่าเท่ากับ 11.98 µg/mL และ 20.02 µg/mL ตามลำดับ การตรวจวัดปริมาณปลอมปนของสารสเตียรอยด์ทั้งสองชนิดในสิ่งตัวอย่างผลิตภัณฑ์สมุนไพรจริงด้วยวิธีที่พัฒนาขึ้นมีค่าสอดคล้องกับผลที่ตรวจด้วยวิธี HPLC และเป็นวิธีที่ใช้งานง่าย มีต้นทุนต่ำ รวดเร็ว และมีศักยภาพนำไปใช้ตรวจหาสิ่งตัวอย่างผลิตภัณฑ์สมุนไพรที่สงสัยว่ามีการปลอมปนของสารสเตียรอยด์ ในระดับภาคสนาม
Gene Expression And Lipid Accumulation In Green Microalga Chlamydomonas Reinhardtii (137c) Under Salt Stress Condition, Thanapa Atikij
Gene Expression And Lipid Accumulation In Green Microalga Chlamydomonas Reinhardtii (137c) Under Salt Stress Condition, Thanapa Atikij
Chulalongkorn University Theses and Dissertations (Chula ETD)
Biodiesel is an important alternative energy that can reduce CO2 emission, the main cause of Global warming. Algal biomass has been considered to be the third generation biofuels. One of the important strategies that enhance lipid accumulation; precursor of biodiesel production, is stress cultivation. High salt concentration is one of a potential approach to enhance lipid accumulation in microalgae. Here, we investigated the impacts of salt on lipid accumulation in green microalga Chlamydomonas reinhardtii (137c). The results revealed that higher concentrations of NaCl, KCl, and LiCl led to increasing of saturated fatty acid contents for 1.8, 1.2, and 1.1 folds …
Development Of In Situ Gel Containing Asiaticoside-Cyclodextrin Complex For Periodontal Tissue Regeneration, Hay Man Saung Hnin Soe
Development Of In Situ Gel Containing Asiaticoside-Cyclodextrin Complex For Periodontal Tissue Regeneration, Hay Man Saung Hnin Soe
Chulalongkorn University Theses and Dissertations (Chula ETD)
Asiaticoside (AS) is active herbal compound isolated from Centella asiatica. It has the potential benefit in promoting type I collagen (COL I) synthesis and osteogenic differentiation in human periodontal ligament cells. However, it has low aqueous solubility which may hamper the bioavailability. Thus, the main objective of this study was to develop the thermoresponsive in situ gels containing AS by using cyclodextrin (CD). To determine the solubility enhancement of AS, phase-solubility profiles were investigated and revealed that CDs enhanced the aqueous solubility of AS. Hydroxypropyl-beta-CD (HPβCD) and sulfobutyl-ether-beta-CD (SBEβCD) were selected due to highly solubilization enhancement of AS. The mucoadhesive …
Promoting Physical Activity And Healthy Eating Behaviorby Nurse Coaching Through Line Application Among Overweight Women In Community, Phayathai District, Bangkok Thailand:A Randomized Controlled Trial, Yuphaporn Hongchuvech
Promoting Physical Activity And Healthy Eating Behaviorby Nurse Coaching Through Line Application Among Overweight Women In Community, Phayathai District, Bangkok Thailand:A Randomized Controlled Trial, Yuphaporn Hongchuvech
Chulalongkorn University Theses and Dissertations (Chula ETD)
The prevalence of overweight and obesity is increased rapidly and becoming a public health problem in many countries of the world including Thailand. Overweight increases the risk of several NCDs. The prevalence of overweight was higher in female than male. The imbalance between energy intake and energy expenditure were the common cause of overweight. The aim of this study was to evaluate the effect of health promotion program by nurse coaching through LINE application to improve knowledge, perception, and practice of physical activity and healthy eating behavior, body composition, blood pressure, and blood glucose among overweight women. A randomized controlled …
Comparison Of The Ocular Microbiome On Ocular Surface Between Chronic Stevens-Johnson Syndrome Patients And Healthy Subjects, Thanachaporn Kittipibul
Comparison Of The Ocular Microbiome On Ocular Surface Between Chronic Stevens-Johnson Syndrome Patients And Healthy Subjects, Thanachaporn Kittipibul
Chulalongkorn University Theses and Dissertations (Chula ETD)
Background: Stevens-Johnson syndrome (SJS) usually causes ocular surface disease. 35% of these patients develop chronic ocular sequelae including symblepharon, limbal stem cell deficiency, etc. The sequelae from SJS may also affect the alteration of ocular microbiome. Subjects: 20 chronic SJS patients and 20 healthy subjects were enrolled for specimen collection from inferior conjunctiva for microbiome analysis by using conventional culture and next-generation sequencing(NGS) methods Methods: Prospective, age and sex matched analytical study Results: A significant higher proportion of culture-positive specimen was demonstrated in SJS group (SJS group 60%, healthy 10%, p-value=0.001). In SJS group, we found significantly higher severity score …
Numerical Simulation And Optimization Of Commercial Sterilization Of Liquid Enteral Nutrition Using Batch Microwave Heating, Tanathep Leungtongkum
Numerical Simulation And Optimization Of Commercial Sterilization Of Liquid Enteral Nutrition Using Batch Microwave Heating, Tanathep Leungtongkum
Chulalongkorn University Theses and Dissertations (Chula ETD)
This thesis contains 3 parts. The first part was to investigate the effect of ingredients on product’s stability and to find optimized oral-feeding enteral nutrition formulas. Since oral-feeding enteral nutrition is high in caloric density, it contains a high amount of calorie sources. Thus, it is likely to have either too high viscosity and/or unstable emulsion. Consequently, 9 factors which are caloric content, oil type, lecithin concentration, fructose syrup to acid ratio, percentage of hydrolyzed whey protein to total protein, percentage of calorie from fat and from fructose syrup to total calorie, complex whey protein concentration, and percentage of whey …
Identification Of Genes And Metabolites Involved In Durian Durio Zibethinus Fruit Ripening, Pinnapat Pinsorn
Identification Of Genes And Metabolites Involved In Durian Durio Zibethinus Fruit Ripening, Pinnapat Pinsorn
Chulalongkorn University Theses and Dissertations (Chula ETD)
Durian (Durio zibethinus M.), a major economic fruit, actively produces infamous sulfur-containing compounds during ripening. However, sulfur metabolism which is important in this fruit is rarely investigated. In this study, the integration of metabolomics using CE-TOF/MS and transcriptomics using de novo RNA-seq assembly was performed to reveal metabolic changes involved in sulfur metabolism and chemical composition related to fruit quality. During ripening, the expression level of genes involved in sulfur metabolism is concurred with the reduced sulfate ion content in placenta and the up-accumulation of sulfur metabolism-related metabolites in pulps. It is noteworthy that durian pulps highly accumulate γ-glutamylcysteine (γ-EC) …
Determination Of Organic Acid Preservatives In Shrimp Paste By Headspace Solid-Phase Microextraction Combined With Gas Chromatography, Nuttanee Tungkijanansin
Determination Of Organic Acid Preservatives In Shrimp Paste By Headspace Solid-Phase Microextraction Combined With Gas Chromatography, Nuttanee Tungkijanansin
Chulalongkorn University Theses and Dissertations (Chula ETD)
Organic acids, which are benzoic acid, sorbic acid and propionic acid, are the most common preservatives used in foods and have been regulated the usage. Shrimp paste, called Kapi in Thai, is a fermented food that used in many Thai dishes. Owing to a complex matrix in shrimp paste, sample preparation is required to determine the amount of organic acid preservatives in shrimp paste. In this work, headspace solid-phase microextraction (HS-SPME) was developed for extraction of organic acid preservatives in shrimp pastes and analyzed by gas chromatography with flame ionization detector (GC-FID). The 85 µm polyacrylate coated fiber was used …
Development Of Simple Devices For Point-Of-Care Screening Of Bacterial Infection And Inflammatory Markers, Julaluk Noiphung
Development Of Simple Devices For Point-Of-Care Screening Of Bacterial Infection And Inflammatory Markers, Julaluk Noiphung
Chulalongkorn University Theses and Dissertations (Chula ETD)
A paper-based analytical devices (PADs) provides a great benefit in medical diagnostics, especially in the developing world. The first part of this dissertation describes the effect of sample viscosity on PADs for the measurement of pH and nitrite concentration in human saliva. Preliminary study found that viscosity had a significant effect on the calibration curve of nitrite and a consistent curve could be generated after added washing buffer. Nitrite measurement in artificial saliva with viscosity 1.87-5.10 mPa-s was tested on the proposed device and also showed a good correlation with the standard spectrophotometry method (p=0.8484, paired sample t-test, n=20). Moreover, …
Production And Purification Of Mannan Oligosaccharide And Its Role In Tight Junction Assembly In Epithelial Cells, Chatchai Nopvichai
Production And Purification Of Mannan Oligosaccharide And Its Role In Tight Junction Assembly In Epithelial Cells, Chatchai Nopvichai
Chulalongkorn University Theses and Dissertations (Chula ETD)
Mannan Oligosaccharide (MOS) is well-known as prebiotic supplement that help increasing life quality of livestocks and animals. Many reports revealed that MOS supplement can help improve intestinal morphology, enhancing growth performance, raising body weight, and increasing metabolic and stress response. MOS feeding also affected several biological processes in peripheral blood mononuclear cells in pigs and modulates expression of many immune-related genes that helps to prevent and reduce the severity of viral infection. However, the mechanism of action of MOS is remained unclear and the production, purification, identification of bioactive MOS molecular type is needed. In this study, we developed a …
Effect Of Feedback-Resistant Arog Overexpression On L-Phenylalanine Production In Escherichia Coli, Maria Ulfah
Effect Of Feedback-Resistant Arog Overexpression On L-Phenylalanine Production In Escherichia Coli, Maria Ulfah
Chulalongkorn University Theses and Dissertations (Chula ETD)
L-Phenylalanine (L-Phe) is one of the most important amino acids in food and pharmaceutical industries. It is widely used as a nutritional supplement and a precursor for the synthesis of food additives. The market of L-Phe has been stimulated by increasing demand for the low-calorie sweetener, aspartame. In Escherichia coli, the key enzyme which catalyzes the first committed step of aromatic amino acid biosynthesis pathway is 3-deoxy-D-arabino-heptulosonate-7- phosphate synthase (DAHP-synthase). The enzyme has 3 isoforms, AroG, AroF and AroH, which are feedback inhibited by L-Phe, L-Tyr and L-Trp, respectively. AroG, encoded by aroG, is the major isoform contributed about 80% …
L-Pipecolic Acid Production In Thra Knockout Escherichia Coli, Suttilak Khuanwilai
L-Pipecolic Acid Production In Thra Knockout Escherichia Coli, Suttilak Khuanwilai
Chulalongkorn University Theses and Dissertations (Chula ETD)
L-pipecolic acid (L-PA) is a non-proteinogenic amino acid, however, it is an important precursor and a key ingredient of many pharmaceutically compound syntheses such as immunosuppressants and anesthetics. The production of amino acids via fermentation of microorganisms are getting attention, one of the widely used is an engineered E. coli. L-PA production in the engineered E. coli uses L-lysine in its cell as a substrate. This research aimed to increase L-PA production by thrA knockout. The thrA encodes homoserine dehydrogenase I, the enzyme which draws the intermediate in L-lysine biosynthesis pathway to synthesize L-threonine. The group II intron insertion was …
The Role Of Cytokine Response Signatures In The Pathogenesis Of Leptospirosis Associated Acute Kidney Injury, Nattachai Srisawat
The Role Of Cytokine Response Signatures In The Pathogenesis Of Leptospirosis Associated Acute Kidney Injury, Nattachai Srisawat
Chulalongkorn University Theses and Dissertations (Chula ETD)
Background: Acute Kidney Injury (AKI) is one of the most serious complications of leptospirosis, an important zoonosis in the tropics. Host pathogen interaction is one of the potential key factor in development of leptospirosis associated AKI. In this multicenter study, we aimed to study the association of cytokines, leptospiral burden, and anti-leptospira antibody and AKI in leptospirosis. Method: In the first cohort, patients who presented with clinical suspiciousness of leptospirosis were prospectively enrolled in 9 centers from August 2012 to November 2014. In the second cohort, we prospectively recruited patients from 15 centers from February 2016 to July 2017. The …
Optimization Of Protein Hydrolysate Preparation And Their Angiotensin I-Converting Enzyme Inhibitory Activity From Shiitake Mushrooms Lentinula Sp., Supawee Paisansak
Optimization Of Protein Hydrolysate Preparation And Their Angiotensin I-Converting Enzyme Inhibitory Activity From Shiitake Mushrooms Lentinula Sp., Supawee Paisansak
Chulalongkorn University Theses and Dissertations (Chula ETD)
Angiotensin-I converting enzyme (ACE) is a key enzyme involved in regulating blood pressure. ACE converts angiotensin-I into angiotensin-II, which results in raised blood pressure. Inhibition of ACE leads to a decreased concentration of angiotensin-II and lowering of blood pressure. Food protein-derived ACE inhibitory peptides are considered to be a safer alternative to antihypertensive drugs. Shiitake mushrooms, one of the most consumed mushrooms in Thailand, are recognized as a nutritive food with health-stimulating properties. The aim of this study was to optimize the preparation of a shiitake-protein hydrolysate and investigate the ACE inhibitory activity of the hydrosylate. Shiitake mushrooms were hydrolyzed …
Reforming Regulation Of Multi-Level Marketing In Myanmar, Zeyar Nyunt Oo
Reforming Regulation Of Multi-Level Marketing In Myanmar, Zeyar Nyunt Oo
Chulalongkorn University Theses and Dissertations (Chula ETD)
The business of multi-level marketing is prohibited in Myanmar under the Notification no 46/2018. There are not only three paragraphs but also lack of the definition of MLM in this Notification. If distributors sell any product through MLM in Myanmar, they will be punished with imprisonment for a term exceeding three years under section 5 of the Myanmar Essential Goods and Services Law 2012. The study of the provisions on the business of MLM in selected ASEAN countries, Indonesia, Malaysia, Thailand, and Singapore indicates that the definition of multi-level marketing and pyramid scheme is not the same. Moreover, businessman and …
Development Of Suture Pad From Silk-Reinforced Polydimethylsiloxane Composite, Radhitya Banuaji Prastowo
Development Of Suture Pad From Silk-Reinforced Polydimethylsiloxane Composite, Radhitya Banuaji Prastowo
Chulalongkorn University Theses and Dissertations (Chula ETD)
The aim of this research is to investigate the mechanical properties of polydimethylsiloxane reinforced with short silk fibers for suture pad application. The effect of aspect ratio and fibers content of the polydimethylsiloxane reinforced with silk fibers on the properties was evaluated. From the results, tensile modulus and tensile strength of polydimethylsiloxane reinforced with different aspect ratio were increased with increasing aspect ratio and fibers content. The composite with the addition of silk fiber produces higher tear resistance with suture thread compared with pure polydimethylsiloxane. Furthermore, the hardness of polydimethylsiloxane reinforced with short silk fibers was improved with the addition …
Fluorescent Sensors From Salicylaldimine Derivatives For Metal Ions, Phoom Sangsuwan
Fluorescent Sensors From Salicylaldimine Derivatives For Metal Ions, Phoom Sangsuwan
Chulalongkorn University Theses and Dissertations (Chula ETD)
An in-situ forming and sensing was developed as a high-throughput screening of fluorescent chemosensors for metal ions. The 45 salicylaldimines, formed in-situ from the condensation between 5 salicylaldehydes and 9 amines, in 96 well-plates were photographed under black light along with the 5 salicylaldehydes in the absence and presence of 18 metal ions. The library of fluorescence response images of these 50 chemosensors were processed into RGB values. The PCA of theΔRGB, the differences between those of images with and without the metal ions, showed 9 sensors with normalized loading value over 70%. The sensor array constructed from these 9 …
The Effect Of Nac And Carnosine On AlzheimerS Disease-Related In Vitro Model Through Rage-Age Signaling Pathway, Suphasarang Sirirattanakul
The Effect Of Nac And Carnosine On AlzheimerS Disease-Related In Vitro Model Through Rage-Age Signaling Pathway, Suphasarang Sirirattanakul
Chulalongkorn University Theses and Dissertations (Chula ETD)
Alzheimer’s disease (AD) is the most common dementia which found increasing with age. It involves neurodegeneration which leads to various abnormalities especially memory loss, inability to learn new things, lack of creativity, lack of decision making ability, lack of critical thinking, calculation inability, inability to live normal daily life, inability to recognize person, time and place, emotional disturbance, and difficulty to use language. Since AD has severe impact in various aspects on both the patients and their families, so we are interested to study the neurodegenerative mechanism when neuronal cells are under oxidative stress which will induce neuroinflammation through the …
Neurodevelopmental And Neurobehavioral Outcomes In Early Antiretroviral Treated Young Children With Perinatally-Acquired Hiv Infection (Phiv) Compared To Age-Matched Perinatally Hiv-Exposed Uninfected Children (Pheu), Watsamon Jantarabenjakul
Neurodevelopmental And Neurobehavioral Outcomes In Early Antiretroviral Treated Young Children With Perinatally-Acquired Hiv Infection (Phiv) Compared To Age-Matched Perinatally Hiv-Exposed Uninfected Children (Pheu), Watsamon Jantarabenjakul
Chulalongkorn University Theses and Dissertations (Chula ETD)
Introduction: Although early initiation of antiretroviral therapy (ART) in perinatally HIV infected (PHIV) infants significantly reduces morbidity and mortality, neurodevelopmental and neurobehavioral problems are still issues of concern. Objectives: This study aims primarily to compare neurodevelopmental outcomes and neurobehavioral outcomes between PHIV children who initiated ART within 12 months of life and perinatally HIV-exposed uninfected (PHEU) children. The secondary aims are to assess the outcomes by timing of ART initiation and to delineate factors and predictors associated with neurodevelopmental and neurobehavioral outcomes. Methods: This study was a prospective observational study which enrolled PHIV and PHEU children aged 12-56 months. Neurodevelopmental …
Direct And Indirect Impacts Of Education On Subjective Well-Being Of Older Persons In Vietnam : Gender Differences, Truc Ngoc Hoang Dang
Direct And Indirect Impacts Of Education On Subjective Well-Being Of Older Persons In Vietnam : Gender Differences, Truc Ngoc Hoang Dang
Chulalongkorn University Theses and Dissertations (Chula ETD)
Vietnam, like many developing countries, is undergoing a rapid pace of population ageing but within a resource limited context. Therefore, understanding the factors that are important to later life well-being has become a key policy issue. Using data from the 2011 Vietnam National Aging Survey, this thesis aims to investigate gender differences in the direct and indirect impacts of education on subjective well-being of older Vietnamese based on four domains: happiness, life satisfaction, loneliness, and depression (N=2,789, including 1,683 females and 1,106 males). The results from path analysis show that those with higher level of education are happier and more …
Impact Of Migration And Remittances On Children's Human Capital In Cambodia, Vatana Chea
Impact Of Migration And Remittances On Children's Human Capital In Cambodia, Vatana Chea
Chulalongkorn University Theses and Dissertations (Chula ETD)
This dissertation investigates the impacts of migration and remittances on human capital development of left-behind children in Cambodia. It contributes new evidence to a controversial debate in the literature on long-term impacts of migration and of remittances on the children. This is from the perspective of education, health, and consumption in remittance-recipient households compared with those in non-recipient ones. It relies on pooled data from Cambodia Socio-Economic Survey of 2009 and 2014, each of which comprises around 12,000 households in both rural and urban areas across all 25 provinces there. To evaluate the impact on household educational investment, the study …
Determinants Of Labor Force Participation Among Older Persons In Myanmar, Zaw Min Latt
Determinants Of Labor Force Participation Among Older Persons In Myanmar, Zaw Min Latt
Chulalongkorn University Theses and Dissertations (Chula ETD)
Population ageing is occurring in many parts of the world. Likewise, in Myanmar, population is ageing with a fast acceleration. The government is trying to find ways to improve wellbeing of older persons, and labour force participation is one of the important factors to reduce financial insecurity during old age. This study aims to investigate the situation of labour force participation and to identify the demographic and economic factors that influence the decision making of older people to join the labour force in Myanmar. This study uses dataset from the 2012 Survey of Older Persons in Myanmar which is nationally …
Quality Enhancement Of Shrimp Paste And Packaging Improvement For A Local Manufacturer, Pongsakorn Sornbunjong
Quality Enhancement Of Shrimp Paste And Packaging Improvement For A Local Manufacturer, Pongsakorn Sornbunjong
Chulalongkorn University Theses and Dissertations (Chula ETD)
The present research focuses on the quality of the shrimp paste manufacturing company by emphasizing product quality improvement as well as packaging improvement for the shrimp paste, which is the main product of the Case Study Company. Presently, the product uses paraffin to cover the shrimp paste for food preservation, which is prohibited by Food and Agricultural Organisation of the United Nations ( FAO) / World Health Organisation (WHO) and Thailand's Food and Drug Administration (FDA).
The research procedure may be divided into 3 phases. The first phase consists of improvement to the physical and chemical properties of the shrimp …
Policy Guideline On Disaster Risk Reduction For Climate Change Adaptation : A Case Of Klong Yan Watershed Resourse Conservation And Rehabilitation Network, Suratthani, Siwaporn Promdaen
Policy Guideline On Disaster Risk Reduction For Climate Change Adaptation : A Case Of Klong Yan Watershed Resourse Conservation And Rehabilitation Network, Suratthani, Siwaporn Promdaen
Chulalongkorn University Theses and Dissertations (Chula ETD)
Thailand is one of South-east Asian countries that have been suffered from extreme events resulting from the impacts of climate change. One consequence of changes is the severity and frequency of extreme events leading to disasters in all regions of Thailand. These effects provided losses and damages at all levels. To solve such problems, water resource management under climate change adaptation has been set up under policy guidelines to reducing the disaster risk from the climate change. The objective of this study is to study the policy guidelines on disaster risk reduction for climate change adaptation on water resource management …