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Role Of Extracellular Adenosine Triphosphate (Eatp) On Immunomodulatory Function Of Human Periodontal Ligament Cells, Maythwe Kyawsoewin
Role Of Extracellular Adenosine Triphosphate (Eatp) On Immunomodulatory Function Of Human Periodontal Ligament Cells, Maythwe Kyawsoewin
Chulalongkorn University Theses and Dissertations (Chula ETD)
Background: Adenosine triphosphate, a nucleotide that acts as an important extracellular messenger, is released into the extracellular environment during various physiologic and pathological conditions. Human periodontal ligament cells (hPDLCs) can release adenosine triphosphate into the extracellular environment in response to mechanical stress. Extracellular adenosine triphosphate (eATP) plays role in both inflammation and osteogenic differentiation processes. eATP also participates in immunosuppressive action on immune cells. However, the role of eATP on the immunomodulatory function of hPDLCs is still unclear. This study aims to investigate the effects of eATP on the immunomodulatory function of hPDLCs and the participation of specific purinergic P2 …
Anti-Inflammatory And Regeneration Properties Of Iloprost On Inflamed Human Dental Pulp Cells Model: An In Vitro Study, Rahman Wahyudi
Anti-Inflammatory And Regeneration Properties Of Iloprost On Inflamed Human Dental Pulp Cells Model: An In Vitro Study, Rahman Wahyudi
Chulalongkorn University Theses and Dissertations (Chula ETD)
In the clinical situation, pulp exposure can happen during caries removal procedures. Inflammation can occur on the pulp of the exposed area because of infiltration of bacteria from caries or as a result of pulp reaction to caries removal drilling. When the pulp was exposed during the caries removal procedure, traditional methods to preserve the pulp such as pulp capping and pulpotomy were performed. The ideal treatment outcome of the pulp exposure is to regain the primary structure of tubular dentin as well as maintain the vitality and healthiness of the dental pulp Thus, good dental materials or drugs used …
Effect Of Shear Force On Immunosuppressive Property Of Human Periodontal Ligament Cells, Ravipha Suwittayarak
Effect Of Shear Force On Immunosuppressive Property Of Human Periodontal Ligament Cells, Ravipha Suwittayarak
Chulalongkorn University Theses and Dissertations (Chula ETD)
The immunomodulatory property is to regulate immune cell function. IDO and TGF-β1 inhibited T cell proliferation and induced regulatory T (Treg) cells differentiation. However, this property must be activated by inflammation. Recently, mechanical forces have also activated this property. Hence, this study investigated effect of shear stress on immunosuppressive property of hPDL cells. Cells were subjected to shear stress then expression of IDO, TGF-β1, IFN-gamma and COX2 mRNA and protein was examined by qRT-PCR, ELISA, and IDO activity. Conditioned media derived shear stress were treated with CD4+ T cells. The proliferative T cell effect was determined using resazurin. The FOXP3, …
Efficacy Of Cannabidiol (Cbd) For The Treatment Of Recurrent Aphthous Ulcers, Chalapinyo Umpreecha
Efficacy Of Cannabidiol (Cbd) For The Treatment Of Recurrent Aphthous Ulcers, Chalapinyo Umpreecha
Chulalongkorn University Theses and Dissertations (Chula ETD)
The objectives of this research were 1) To investigate the allergic reactions to cannabidiol (CBD) when used on human skin. 2) To assess local and systemic side effects of CBD when used on normal oral mucosa. 3) To compare the efficacy among 0.1% CBD, 0.1% triamcinolone acetonide (TA), and placebo (pure oral paste) in recurrent aphthous ulcer (RAU) treatment. This project was composed of 3 phases. Phase 1, a skin patch test was performed on 100 healthy subjects. Phase 2, CBD was applied to normal oral mucosa of 50 healthy subjects 3 times/day for 7 days. Oral examination, vital signs, …
Effects Of Local Versus Systemic Administration Of Cxcr4 Inhibitor Amd3100 On Orthodontic Tooth Movement In Rats, Narubhorn Ongprakobkul
Effects Of Local Versus Systemic Administration Of Cxcr4 Inhibitor Amd3100 On Orthodontic Tooth Movement In Rats, Narubhorn Ongprakobkul
Chulalongkorn University Theses and Dissertations (Chula ETD)
Chemokines play pivotal roles in orthodontic tooth movement (OTM) through osteoclast-mediated bone resorption, but the underlying mechanism remains unclear. We aimed to elucidate the effects of serial local vs systemic administration of the chemokine receptor CXCR4 antagonist AMD3100 on OTM. The maxillary right first molar (M1) of rats was moved mesially using a 10 g of force nickel-titanium coil spring. The injections were performed every other day with phosphate-buffered saline as a control, whereas local and systemic animals were injected with AMD3100 at the buccal palatal mucosa adjacent to M1 and subcutaneously, respectively. OTM distance and alveolar bone were examined …
Differences Of Sound And Morphology In Skeletal Class Iii Patients, Natthaporn Pravitharangul
Differences Of Sound And Morphology In Skeletal Class Iii Patients, Natthaporn Pravitharangul
Chulalongkorn University Theses and Dissertations (Chula ETD)
[Background] This study aimed to explore differences in vowel production using acoustic analysis in skeletal Class III and Class I Japanese participants, and to investigate the correlation between vowel sounds and cephalometric variables in skeletal Class III subjects. [Materials and Methods] Japanese males with skeletal Class III (ANB<0°) and Class I skeletal relationships (0.62°
The Designs Of Miniscrew-Assisted Transpalatal Arch Affect Molar Intrusion, Ornnicha Pooktuantong
The Designs Of Miniscrew-Assisted Transpalatal Arch Affect Molar Intrusion, Ornnicha Pooktuantong
Chulalongkorn University Theses and Dissertations (Chula ETD)
Abstract: An anterior open bite is one of the most difficult malocclusions in orthodontic treatment. For such malocclusion, orthodontic miniscrews insertion into both buccal and palatal alveolar regions has been indicated for molar intrusion, but it involves a risk of tooth root injury. To solve the problem, midpalatal miniscrew-attached extension arm (MMEA) is adopted. However, this method causes palatal tipping of the molar because intrusive loads were applied only from palatal side. Currently, transpalatal arch is added to avoid tipping movement, but it induces patient's discomfort. Hence, the objective of this study was to evaluate the loading conditions for maxillary …
Effects Of Intrauterine Intermittent Hypoxia On Skeletal Muscle In Offspring Rats, Wirongrong Wongkitikamjorn
Effects Of Intrauterine Intermittent Hypoxia On Skeletal Muscle In Offspring Rats, Wirongrong Wongkitikamjorn
Chulalongkorn University Theses and Dissertations (Chula ETD)
Gestational intermittent hypoxia (IH), a hallmark of OSA, alters the offspring's respiratory neural control and diaphragm contractile function. Thus, we aimed to investigate the effects of gestational IH on the muscle development and metabolism of geniohyoid (GH), which is innervated by the respiratory-related hypoglossal nerve and plays a role in tongue traction and suckling, in male offspring rats compared with masseter (MAS), the largest masticatory muscle. Pregnant Sprague-Dawley rats were exposed to IH (3-min periods of 4–21% O2) compared to Normoxia for 8 hours/day during gestational days 7–20. GH and MAS from 35-day-old male offspring (n = 6 /group) were …
Cellular Responses Of Stem Cells Isolated From Human Exfoliated Deciduous Teeth Towards Different Concentration Of Calcium Ion, Thanika Phlinyos
Cellular Responses Of Stem Cells Isolated From Human Exfoliated Deciduous Teeth Towards Different Concentration Of Calcium Ion, Thanika Phlinyos
Chulalongkorn University Theses and Dissertations (Chula ETD)
Objectives: The purpose of this study was to investigate the effect of Ca2+ on proliferation, osteogenic differentiation, and migration of stem cells from human exfoliated teeth (SHEDs) in vitro Materials and methods: SHEDs were seeded in culture media and osteogenic induction media containing 1.8-16.2 mM of Ca2+. SHEDs proliferation was determined using MTT assay and colony forming unit assay. Osteogenic differentiation was evaluated using mineralization assay and osteogenic marker gene expression and cell migration was evaluated using wound healing assay. Values were expressed as mean + S.D. Statistical analysis of MTT assay and wound healing assay were performed using two-way …
Expression Of Vascular Endothelial Growth Factor Protein In Mrna-Transfected Human Periodontal Ligament Cells, Mana Naratippakorn
Expression Of Vascular Endothelial Growth Factor Protein In Mrna-Transfected Human Periodontal Ligament Cells, Mana Naratippakorn
Chulalongkorn University Theses and Dissertations (Chula ETD)
The complete regeneration of periodontal tissues following current periodontal therapy remain challenging and unpredictable. Nucleoside-modified messenger RNA (mRNA) technology can be a promising novel platform in regenerative medicine. The aims of this study were to evaluate whether pseudouridine modified mRNA encoding vascular endothelial growth factor (VEGF) could induce VEGF production in human periodontal ligament cells (PDLCs) and this translated protein function by promoting in vivo blood vessel formation using chorioallantoic membrane (CAM) assay. Isolated PDLCs from healthy periodontal tissue were transfected with modified mRNA encoding VEGF (VEGF mRNA) complexed with a transfecting agent, Lipofectamine 2000 (L2000) and L2000 alone (control). …
Clinical Efficacy Of Silk Sericin Dressing With Collagen For Split-Thickness Skin Graft Donor Site Treatment, Apirujee Punjataewakupt
Clinical Efficacy Of Silk Sericin Dressing With Collagen For Split-Thickness Skin Graft Donor Site Treatment, Apirujee Punjataewakupt
Chulalongkorn University Theses and Dissertations (Chula ETD)
Sericin dressing containing collagen hydrolysate (SDC) was evaluated in this study, consisting of two phases of clinical trials. The clinical safety of SDC was determined using a patch test in 103 healthy volunteers (phase I). Most of the results (around 90%) in the SDC group were interpreted as negative and doubtful reactions, and the remaining results (around 10%) were weak reactions. After that, the clinical efficacy and safety of SDC were investigated in 21 patients with 30 split-thickness skin graft (STSG) donor sites (phase II). Each donor site was divided into two equal sites. SDC or the commercial dressing (Bactigras®) …
Production Optimization Of Porcine Reproductive And Respiratory Syndrome (Prrs) Virus Nucleocapsid Protein In Nicotiana Benthamiana, Boonyasit Porngarm
Production Optimization Of Porcine Reproductive And Respiratory Syndrome (Prrs) Virus Nucleocapsid Protein In Nicotiana Benthamiana, Boonyasit Porngarm
Chulalongkorn University Theses and Dissertations (Chula ETD)
Porcine Reproductive and Respiratory Syndrome virus (PRRSV) is a considerable pathogen to occur disease in pigs and effect to economic on the swine industry around the world including Thailand. Routine observation, rapid diagnosis of PRRSV infection is essential for effective monitoring and disease control. The serological assays using highly conserved viral nucleocapsid (N) protein are widely used for the detection of antibodies to the PRRSV. Accordingly, this study was aimed to produce the N-protein of the PRRSV in the plant system by using Nicotiana benthamiana. The N-protein gene was designed into four constructs that contained with and without the plant …
Antioxidant Activity Of Thunbergia Laurifolia Lindl. Ethanolic Extract In Keratinocytes, Buakotchaphan Jirabanjerdsiri
Antioxidant Activity Of Thunbergia Laurifolia Lindl. Ethanolic Extract In Keratinocytes, Buakotchaphan Jirabanjerdsiri
Chulalongkorn University Theses and Dissertations (Chula ETD)
Fine particulate matter (PM2.5) can cause skin damage through the induction of oxidative stress in epidermis. Antioxidants help counteract with cellular oxidant species and maintain cell homeostasis. This study aims to examine the protective effect of Thunbergia laurifolia lindl. ethanolic extract on PM2.5-mediated oxidative stress in epidermal keratinocytes. High-performance liquid chromatography with diode array detection was conducted for quantitative analysis of rosmarinic acid content in the extract. Cell viability was detected by the 3-(4,5-Dimethylthiazol-2-yl)-2,5-Diphenyltetrazolium Bromide assay. Intracellular ROS was monitored using 2’,7’-Dichlorodihydrofluorescein diacetate. Proteins related to p62-Keap1-Nrf2 signaling pathway were examined by western blot analysis. Expressions of Nrf2 and p62 …
Antioxidant With Antimelanogenic Activities Of Sericin Hydrolysates Optimized By Response Surface Methodology In Human Melanin-Generating Mnt-1 Cells, Keerati Joyjamras
Antioxidant With Antimelanogenic Activities Of Sericin Hydrolysates Optimized By Response Surface Methodology In Human Melanin-Generating Mnt-1 Cells, Keerati Joyjamras
Chulalongkorn University Theses and Dissertations (Chula ETD)
Sericin, a protein presenting in the wastewater from silk industry, causes water pollution and ecological problem. To increase economic value to this waste product, the optimum enzymatic condition that could create sericin hydrolysates with high antioxidant and antimelanogenic capacities was generated through response surface methodology (RSM). Response surface plots demonstrate the major role of temperature on scavenging capacity of sericin hydrolysates assessed via DPPH, FRAP and ORAC assays. Alcalase®-hydrolyzed sericin consisted of sericin-related peptides in differing amounts and smaller sizes compared with unhydrolyzed sericin, as respectively demonstrated by peptidomic and SDS-PAGE analysis. Pre-incubation with 20 mg/mL sericin hydrolysates digested by …
Development Of Plant-Produced Subunit Vaccine And Therapeutic Protein For Covid-19, Konlavat Siriwattananon
Development Of Plant-Produced Subunit Vaccine And Therapeutic Protein For Covid-19, Konlavat Siriwattananon
Chulalongkorn University Theses and Dissertations (Chula ETD)
Due to the rapid transmission of the Coronavirus Disease 2019 (COVID-19) causing serious public health problems and economic burden, the development of effective therapeutic interventions is urgently needed for controlling the ongoing pandemic disease. In this study, we have transiently produced recombinant SARS-CoV-2 RBD and human ACE2 fused with the Fc region of human IgG1 in Nicotiana benthamianain in order to use as a preventive subunit vaccine and therapeutic against SARS-CoV-2. The recombinant SARS-CoV-2 RBD-Fc subunit vaccine was formulated with different commercially available adjuvants including aluminium hydroxide gel (Alum), AddaVaxTM (MF59), monophosphoryl lipid A from Salmonella Minnesota R595 (mPLA-SM), and …
Taxonomy And Biological Activities Of A Novel Saccharothrix Species From Soil Of Sichang Island, Md Abul Kalam Azad
Taxonomy And Biological Activities Of A Novel Saccharothrix Species From Soil Of Sichang Island, Md Abul Kalam Azad
Chulalongkorn University Theses and Dissertations (Chula ETD)
Actinobacteria are the sources of bioactive natural products. Rare actinobacteria are the less frequently isolated genera of actinobacteria. During an investigation of diversity of rare actinobacteria, actinobacteria isolate SC076T was isolated from a soil sample collected from Sichang Island, Chonburi Province, Thailand. The strain showed the highest 16S rRNA gene similarity to Saccharothrix australiensis DSM 43800T (98.58%) and Saccharothrix espanaensis DSM 44229T (98.58%). The zigzag morphology of the spore chain was observed on the aerial mycelia. meso-diaminopimelic acid was detected in the peptidoglycan. Whole-cell sugars contained rhamnose, ribose, mannose glucose and galactose. Polar lipids are phosphatidylethanolamine, hydroxyphosphatidylethanolamine, diphosphatidylglycerol, phosphatidylglycerol, phosphatidylinositol …
Effect Of Hydroquinone 5-O-Cinnamoyl Ester Of Renieramycin M On The Suppression Of Lung Cancer Stem Cells, Nattamon Hongwiangchan
Effect Of Hydroquinone 5-O-Cinnamoyl Ester Of Renieramycin M On The Suppression Of Lung Cancer Stem Cells, Nattamon Hongwiangchan
Chulalongkorn University Theses and Dissertations (Chula ETD)
Cancer stem cells (CSCs) are distinct cancer populations with tumorigenic and self-renewal abilities. CSCs are drivers of cancer initiation, progression, therapeutic failure, and disease recurrence. Thereby, novel compounds targeting CSCs offer a promising way to control cancer. In this study, the hydroquinone 5-O-cinnamoyl ester of renieramycin M (CIN-RM) was demonstrated to suppress lung cancer CSCs. CIN-RM was toxic to lung cancer cells with a half-maximal inhibitory concentration around 15 µM. CIN-RM suppressed CSCs by inhibiting colony and tumor spheroid formation. In addition, the CSC population was isolated and treated and the CSCs were dispatched in response to CIN-RM within 24 …
Α-Glucosidase Inhibitors From Dendrobium Delacourii, Dendrobium Gibsonii And Aerides Multiflora, May Thazin Thant
Α-Glucosidase Inhibitors From Dendrobium Delacourii, Dendrobium Gibsonii And Aerides Multiflora, May Thazin Thant
Chulalongkorn University Theses and Dissertations (Chula ETD)
In this study, three plants from the Orchidaceae family, i.e., Dendrobium delacourii, Dendrobium gibsonii, and Aerides multiflora, were investigated for their chemical constituents and α-glucosidase inhibitory activities. A total of thirty compounds were isolated and structurally characterized. Eleven known compounds were identified from Dendrobium delacourii, including hircinol, ephemeranthoquinone, densiflorol B, moscatin, 4,9-dimethoxy-2,5-phenanthrenediol, gigantol, batatasin III, lusianthridin, 4,4',7,7'-tetrahydroxy-2,2'-dimethoxy-9,9',10,10'-tetrahydro-1,1'-biphenanthrene, phoyunnanin E, and phoyunnanin C. Two new compounds, i.e., dihydrodengibsinin and dendrogibsol, were isolated from Dendrobium gibsonii, along with seven known compounds including ephemeranthol A, dengibsinin, nobilone, aloifol I, lusianthridin, denchrysan A, and 4-methoxy-9H-fluorene-2,5,9-triol. Four new compounds, i.e., aerimultins A-C and dihydrosinapyl dihydroferulate, …
Lipase Inhibitors From Dendrobium Senile, Myat Pann Phyu
Lipase Inhibitors From Dendrobium Senile, Myat Pann Phyu
Chulalongkorn University Theses and Dissertations (Chula ETD)
Obesity is characterized as an abnormal lipid metabolism due the imbalance between the energy intake and output. Pancreatic lipase is secreted by the pancreas and plays an important role in the digestion and absorption of lipids in the small intestine. Inhibition of pancreatic lipase enzyme can reduce dietary fat absorption which will lead to loss of weight and finally result in hypocholesterolemia and hypoglycemia. From the whole plant of Dendrobium senile, a new phenanthrene derivative was isolated, together with seven known compounds, including 2,5,7-trihydroxy-4-methoxyphenanthrene (1), moscatin (2), 2,5-dihydroxy-4,9-dimethoxyphenanthrene (3), moscatilin (4), aloifol I (5), 4,4ʹ,8,8ʹ-tetramethoxy[1,1ʹ-biphenanthrene]-2,2ʹ,7,7ʹ-tetrol (6), 2,2ʹ,7,7ʹ-tetrahydroxy-4,4ʹ-dimethoxy-1,1ʹ-biphenanthrene (7) and bleformin …
Identification, Antifungal And Plant Growth Promoting Activities Of Endophytic Actinomycetes From Orchids, Nisachon Tedsree
Identification, Antifungal And Plant Growth Promoting Activities Of Endophytic Actinomycetes From Orchids, Nisachon Tedsree
Chulalongkorn University Theses and Dissertations (Chula ETD)
Sixty-two endophytic actinomycetes were isolated from 15 Thai orchids. They were identified as Streptomyces (34 isolates), Micromonospora (21 isolate), Streptosporangium (2 isolates), Actinomadura (1 isolates), Amycolatopsis (3 isolates) and Pseudonocardia (1 isolates) based on their phenotypic, chemotaxonomic and genotypic characteristics. The antimicrobial activity screening revealed that Streptomyces (18 isolates), Micromonospora (12 isolates) and Streptosporangium (1 isolate) exhibited antimicrobial activity against Bacillus subtilis ATCC 6633, Kocuria rhizophila ATCC 9341, Staphylococcus aureus ATCC 25923, Escherichia coli ATCC 25922, Pseudomonas aeruginosa ATCC 27853 and Candida albicans ATCC 10231. Strain DR2-2 could inhibit all tested pathogens. Based on 16S rRNA gene sequencing, strain DR6-1 …
Extraction Of Cannabinoids Using Vegetable Oils And Its Uva-Photoprotective Effect On Human Skin Keratinocytes, Nur Alfan Muhammad Zen
Extraction Of Cannabinoids Using Vegetable Oils And Its Uva-Photoprotective Effect On Human Skin Keratinocytes, Nur Alfan Muhammad Zen
Chulalongkorn University Theses and Dissertations (Chula ETD)
Nowadays, vegetable oil has attracted attention in its role as an alternative solvent. Its ability to dissolve various active compounds from plants has been proven by several previous studies. Moreover, other benefits of the use of vegetable oil as a solvent are affordable, non-toxic, and eco-friendly. The extraction process is one of the crucial factors that affect the quality of cannabis. Ethanol is still consistently the best solvent for cannabis extraction in terms of yield production compared to other organic solvents used in this study including oil whose yield cannot be calculated since vegetable oil cannot be evaporated. HPTLC fingerprint …
Production And Characterization Of Escherichia Coli Outer Membrane Vesicles Displaying Anti-Muc1 Single-Chain Variable Fragment Via Spytag/Spycatcher System, Sedthawut Laotee
Production And Characterization Of Escherichia Coli Outer Membrane Vesicles Displaying Anti-Muc1 Single-Chain Variable Fragment Via Spytag/Spycatcher System, Sedthawut Laotee
Chulalongkorn University Theses and Dissertations (Chula ETD)
Outer membrane vesicles (OMVs) secreted from Gram-negative bacteria have been discovered for a decade. Special features like high stability, ease of production, and intrinsic adjuvanticity highlight the use of OMVs in diverse applications such as vaccination, bioimaging, and multifunctional delivery systems. Synthetic biological approaches can functionalize OMVs to present heterologous proteins by expressing genetic fusion of target protein to outer membrane proteins. However, complex proteins cannot be incorporated into the OMVs due to lack of some post-translational modifications in bacteria. Herein, we demonstrated a convenient method for presentation of versatile proteins in OMVs with the implementation of the bio-ligation system …
3,4-Dihydroxy-5,4’-Dimethoxybibenzyl Sensitizes Non-Small Cell Lung Cancer Cells To Cisplatin-Induced Apoptosis Via P53 Upregulation, Hardyanti Eka Putri
3,4-Dihydroxy-5,4’-Dimethoxybibenzyl Sensitizes Non-Small Cell Lung Cancer Cells To Cisplatin-Induced Apoptosis Via P53 Upregulation, Hardyanti Eka Putri
Chulalongkorn University Theses and Dissertations (Chula ETD)
Lung cancer is a leading fatal malignancy with the highest number of cancer deaths. Targeting a specific protein regulating cancer progression and metastasis has been attracting much attention for the development of cancer therapy. Thus, this study was aimed to investigate the effect of 3,4-dihydroxy-5,4′-dimethoxybibenzyl (DS-1) in targeting MDM2-attenuating p53 function and inhibition EMT in lung cancer cells. The efficacy of DS-1 or combined with cisplatin in lung cancer cells was determined by MTT, nuclear staining, and Annexin V/PI assays. The expression of apoptosis- and EMT-related proteins was determined by western blot analysis. Metastatic behaviors were evaluated by cell shape …
Cross-Cultural Adaptation And Psychometric Properties Of The Thai Version Of The Neurophysiology Of Pain Questionnaire, Pichet Pasangkayo
Cross-Cultural Adaptation And Psychometric Properties Of The Thai Version Of The Neurophysiology Of Pain Questionnaire, Pichet Pasangkayo
Chulalongkorn University Theses and Dissertations (Chula ETD)
Background: Pain neurophysiology knowledge is hypothesized to influence pain beliefs and physical performance in individuals with chronic low back pain (LBP). Valid and reliable measures of such knowledge is important to evaluate the pain treatment on this domain as well as to understand its role in both physical and psychological functions of individuals with chronic pain. This study aimed to culturally adapt the revised Neurophysiology of Pain Questionnaire into Thai (T-rNPQ), using the Functional Assessment of Chronic Illness Therapy (FACIT) methodology, and to evaluate its reliability and validity. Two hundred sixty-three individuals with chronic LBP completed the T-rNPQ and seven …
Effect Of Pongol Methyl Ether On Cancer Stem Cell Phenotypes In Human Non-Small Cell Lung Cancer Cells, Arnon Silapech
Effect Of Pongol Methyl Ether On Cancer Stem Cell Phenotypes In Human Non-Small Cell Lung Cancer Cells, Arnon Silapech
Chulalongkorn University Theses and Dissertations (Chula ETD)
Cancer stem cells (CSCs) are an important therapeutic target. The therapeutic agents targeting CSCs should lead to improved clinical outcomes. This study demonstrated the CSC suppressing activity of pongol methyl ether (PME), a pure compound from Millettia erythrocalyx Gagnep. CSC-suppressing effects were evaluated by colony formation assay, anchorage independent growth assay, spheroid formation assay and detection of CSC markers. The related CSC cell signals were evaluated by Western blot, immunofluorescence and molecular docking analysis. Proteins affected by PME treatment were subjected to bioinformatic analysis. Protein–protein interaction (PPI) networks were constructed by the Search Tool for Interactions of Chemicals (STITCH). The …
The Effect Of Population Structure On Economic Development: Thailand's Provincial Panel Data, Satayu Pattarakijkusol
The Effect Of Population Structure On Economic Development: Thailand's Provincial Panel Data, Satayu Pattarakijkusol
Chulalongkorn University Theses and Dissertations (Chula ETD)
This research investigates the effects of demographic change, the change of labor supply, and human capital on Thailand’s economic development. This will help shed light on the relationship between population (quantitatively and qualitatively) and economic development. The demographic dividends, the neoclassical growth Solow-Swan model, and human capital are adopted as the conceptual framework for this research. The secondary panel data at the provincial level from government officials will be used for statistical analysis. Fixed effect or random effect with lagged dependent variable is introduced into the estimated model. The finding suggests that the labor productivity, employment level, share of the …
The Efficacy Of Universal Ceramic Polishing Kit On The Surface Roughness Of Various Ceramic Types, Ekaluck Poosanthanasarn
The Efficacy Of Universal Ceramic Polishing Kit On The Surface Roughness Of Various Ceramic Types, Ekaluck Poosanthanasarn
Chulalongkorn University Theses and Dissertations (Chula ETD)
The objective of this vitro study was to determine the effect of polishing performance of a universal ceramic polishing kit on the surface roughness of various ceramics. The ceramic specimen size 5 x 7 x 4 mm of lithium disilicate glass ceramic (IPS e.max CAD, Ivoclar Vivadent, Liechtenstein), translucent zirconia (VITA YZ XT, VITA Zahnfabrik, Germany) and zirconia-reinforced lithium silicate (Celtra Duo, Dentsply Sirona, United States) (n=8) were fixed with clear resin in PVC block, 14 mm in diameter. The specimens were ground with fine diamond bur for 15 seconds to simulate clinical gross contouring.The two-step polishing process started with …
The Effects Of The Oral Exercises On The Oral Function Of People With Dementia, Kwanrutai Somsak
The Effects Of The Oral Exercises On The Oral Function Of People With Dementia, Kwanrutai Somsak
Chulalongkorn University Theses and Dissertations (Chula ETD)
The objective of this study was to examine the effects of the home-based oral exercises on the oral function in people with mild to moderate dementia. The patients with mild to moderate dementia at King Chulalongkorn Memorial Hospital, who were randomly allocated to an experimental group (n = 11), were asked to perform 3 home-based oral exercises for 3 months while those in a control group (n = 11) did not do any oral exercises. The oral function including maximum tongue pressure (MTP), oral diadochokinesis (ODK) rates of /ta/, /ka/, /pa/, swallowing function (modified water swallowing test: MWST), and oral …
Antifungal, Physical, And Mechanical Properties Of Tissue Conditioner Incorporated With Zinc Oxide Nanoparticles, Woraporn Homsiang
Antifungal, Physical, And Mechanical Properties Of Tissue Conditioner Incorporated With Zinc Oxide Nanoparticles, Woraporn Homsiang
Chulalongkorn University Theses and Dissertations (Chula ETD)
This study evaluated the antifungal, physical, and mechanical properties of tissue conditioner incorporated with different amounts of zinc oxide nanoparticles (ZnOnps) at different storage times (0, 7, and 14 days). Specimens of 0, 5, 10, 15 wt% ZnOnps, or 15 wt% nystatin incorporated into tissue conditioner were fabricated. The direct contact test (n=6) was performed to evaluate the antifungal effect against C. albicans suspension. Scanning electron microscopy and energy dispersive X-ray spectroscopy (n=6) were used to observe the amount and distribution of superficial zinc element. The penetration depth (n=6) and tensile bond strength (n=8) were evaluated following ISO 13139. The …
Investment Model Of Commitment To Parasocial Interaction And Purchase Intention Among Beauty Youtuber Followers, Parima Kosakarn
Investment Model Of Commitment To Parasocial Interaction And Purchase Intention Among Beauty Youtuber Followers, Parima Kosakarn
Chulalongkorn University Theses and Dissertations (Chula ETD)
Internet celebrities, such as Youtuber, have become an important figure in influencing purchase intention among viewers. This effect was linked to the parasocial interaction, which is prominently studied in communication and marketing fields. This research aimed to broaden this link by using a social psychological theory. Thus, the purpose of this research was to examine the effect of commitment (according to the Investment Model of Commitment Processes) and parasocial interaction on purchase intention of endorsed beauty products. Data were collected using internet-based survey from 181 participants, who were (1) Youtube users i.e., having Youtube accounts, (2) subscribing to a channel …