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Accuracy Comparison Of Dental Implants Obtained By Dynamic Cais In All-On-4 Edentulous Area Among Different Types Of Bone Density: An In Vitro Study, Jutasinee Pornpolsarun
Accuracy Comparison Of Dental Implants Obtained By Dynamic Cais In All-On-4 Edentulous Area Among Different Types Of Bone Density: An In Vitro Study, Jutasinee Pornpolsarun
Chulalongkorn University Theses and Dissertations (Chula ETD)
Background: Determination of available bone is particularly important in implant placement quality of bone can affect the accuracy implant placement. Currently, Dynamic navigation system illustrated the improvement of implant accuracy, The accuracy of implant placement using computer-assisted implant placement system (CAIS) is unknown. As a result, the goal of this study was to see how bone density affected implant placement accuracy with Dynamic CAIS. Purpose: To determine the effect of different bone density in the accuracy of implant placement using dynamic navigation system Materials and Methods: The study's overall design includes a single doctor planning each implant using a CBCT …
A Comparison Of Implant Stability Between Two Implant Systems Using Guided Surgery In Inexperienced Surgeons, Pinmuk Supachaiyakit
A Comparison Of Implant Stability Between Two Implant Systems Using Guided Surgery In Inexperienced Surgeons, Pinmuk Supachaiyakit
Chulalongkorn University Theses and Dissertations (Chula ETD)
Aim: To investigate the implant stability in relation to two different implant designs, a cylindrical shaped single threaded design (CS/ST) and a tapered shaped double threaded design (TS/DT) using RFA over the first 8 weeks. Materials and Methods: 28 implants were randomly allocated into two groups and were placed as single tooth implant in the posterior arch. CBCT scan was used to determine the bone density and the implants were placed with guided surgical template by inexperienced surgeons which were prepared with the same implant planning software. The implant stability was measured using the RFA over the first 8 weeks …
Clinical Accuracy Between Planned And Placed Posterior Implant Position Of Two Static Implant Planning Software Programs In Inexperienced Operators, Wanwanat Singthong
Clinical Accuracy Between Planned And Placed Posterior Implant Position Of Two Static Implant Planning Software Programs In Inexperienced Operators, Wanwanat Singthong
Chulalongkorn University Theses and Dissertations (Chula ETD)
Objective: This study aimed to evaluate and examine the difference in posterior implant positioning between the planned and placed positions when inexperienced operators used two static implant planning software packages following a fully guided implant surgery protocol in the clinical field. Materials and methods: Twenty-four patients who needed single posterior implant placement were randomly divided into two groups based on the used implant planning software (group 1, coDiagnostiX, n=12; group 2, Implant Studio, n=12). The dataset of the placed implant position, generated from digitizing the implant impression, was superimposed on the planned implant position. The number of horizontal, angular, and …
Eu-Vietnam Fta: Implications For Thailand, Uthaipan Promkhatkaew
Eu-Vietnam Fta: Implications For Thailand, Uthaipan Promkhatkaew
Chulalongkorn University Theses and Dissertations (Chula ETD)
In 2007, the EU launched a region-to-region Free Trade Agreement (FTA) with the ASEAN; however, negotiations were suspended in 2009, and the EU subsequently decided to negotiate bilateral FTAs with individual ASEAN member states. Thailand, a parliamentary democratic country, launched the first round of trade negotiations with the EU in 2013, but they were put on hold due to the military coup in 2014. On the other hand, the EU still continued to negotiate and ultimately concluded the FTA with Vietnam in 2020 despite the fact that Vietnam is one of the world’s five remaining communist states. This has raised …
Diversification Benefits Of Commodity Indices Versus Islamic Stock Indices, Sita Khan
Diversification Benefits Of Commodity Indices Versus Islamic Stock Indices, Sita Khan
Chulalongkorn University Theses and Dissertations (Chula ETD)
The objective of this study is to investigate conditional correlations between the Dow Jones Emerging Market index and commodity indices (i.e., agriculture, energy, industrial metals, livestock, precious metals) and Islamic stock indices (i.e., JKII, KLFTEMSI, MSCI Bahrain, MSCI Kuwait, and MSCI Qatar). Additionally, this paper classifies the properties of assets whether it is a diversifier, a hedger, or a safe-haven assets to the Dow Jones Emerging Market index. The estimation method is the dynamic conditional correlation generalized autoregressive conditional heteroskedasticity (DCC-GARCH) model to estimate the conditional correlations during the period of 2007-2021 which covers the Global financial crisis (GFC) and …
Investigation Of Statistical Seismology In Thailand-Laos-Myanmar Borders, Manunchaya Neanudorn
Investigation Of Statistical Seismology In Thailand-Laos-Myanmar Borders, Manunchaya Neanudorn
Chulalongkorn University Theses and Dissertations (Chula ETD)
The purpose of this research is to understand more about the statistical seismology of the Thailand-Laos-Myanmar border in order to monitor earthquake activity and locate potentially dangerous area. The seismicity data was collected from the Thailand Meteorological Department. Following that, the catalog's homogeneity and completeness were improved. The first step is to identify the earthquake activity by using the adaptive frequency-magnitude distribution. The results are that Nan province, Thailand, and south Luang Prabang, Laos are the highest activity areas which can generate a maximum magnitude of 5.1 ML, 5.6 ML, 6.3 ML, and 6.7 ML in 5, 10, 30, 50 …
The Effectiveness Of Asiaticoside On Osteogenic Differentiation Ability In Aging Human Periodontal Ligament Cells In Vitro, Adisa Suthirathikul
The Effectiveness Of Asiaticoside On Osteogenic Differentiation Ability In Aging Human Periodontal Ligament Cells In Vitro, Adisa Suthirathikul
Chulalongkorn University Theses and Dissertations (Chula ETD)
Retaining teeth is essential for the quality of life of the aging population. However, aging has biological effects in periodontal ligament cells with significant changes in their proliferative rate and regenerative function. Asiaticoside, extracted from Centella asiatica, was found to have potential in osteogenic differentiation and mineralization in human periodontal ligament cells (HPDLCs). The aim of this study is to investigate the effect of asiaticoside on the aging HPDLCs osteogenic differentiation and mineralization. Aging HPDLCs, retrieved from patients age 60 and above, were confirmed aging status using Senescence-Associated ß -Galactosidase assay. The cells were incubated with various concentrations of asiaticoside …
Utilization Of Rain Tree (Samanea Saman) Residue As Modified Adsorbent To Treat Oil And Grease In Canteen Wastewater, Elga Riesta Puteri
Utilization Of Rain Tree (Samanea Saman) Residue As Modified Adsorbent To Treat Oil And Grease In Canteen Wastewater, Elga Riesta Puteri
Chulalongkorn University Theses and Dissertations (Chula ETD)
The utilization of waste materials as adsorbent precursors is gaining intention to treat fats, oils, and greases (FOG), especially in wastewater treatment. Tree residue, an abundant waste, provides a potential feedstock to be converted into valuable materials. This research aimed to develop modified adsorbent prepared from rain tree (Samanea saman) residue for FOG treatment. The synthesis process of modified adsorbent was conducted by chemical pretreatment using different chemical agents (i.e., NaOH, ZnCl2, and H3PO4). The pre-treated twigs and leaves (1:4 ratio) were continued by pyrolysis process at different temperatures (i.e., 350, 550, and 750oC) using a heating rate of 10oC …
Surface Activation Of Rice Husk-Derived Hydrochar As An Adsorbent For Atrazine And Ammonium, Kim Anh Phan
Surface Activation Of Rice Husk-Derived Hydrochar As An Adsorbent For Atrazine And Ammonium, Kim Anh Phan
Chulalongkorn University Theses and Dissertations (Chula ETD)
Due to the agricultural intensity, studies of sustainable solutions for atrazine and nitrogen contamination have attracted more attention. This study is aimed to develop rice husk hydrochar as an adsorbent for atrazine and ammonium adsorption. Effects of microwave-assisted hydrothermal carbonization (MHTC) conditions including temperature (150 – 200°C), residence time (20 – 60 min), and liquid to solid ratio (5:1 – 15:1 mL/g) on the atrazine and ammonium adsorption capacity were investigated. Surface activation of rice husk hydrochar samples was synthesized using potassium hydroxide (KOH) and hydrogen peroxide (H2O2) with various concentrations. The results showed that higher MHTC temperature with higher …
Changes In Surface Water And Sediment Quality At A Complex Tidal-Influenced River: A Case Study Of Ganh Hao River, Mekong Delta, Vietnam, Muoi Le Van
Chulalongkorn University Theses and Dissertations (Chula ETD)
The research was carried out to determine the extent of surface water and sediment pollution using the physicochemical parameters and heavy metal concentrations. The surface water and sediment samples were obtained from 25 sites along the river on March 22 and September 5, 2019 at the main river influenced by the complex tidal regime and aquaculture practices in Ca Mau peninsular in the Vietnamese Mekong Delta. The water quality was compared with international and national standards, while the sediment quality was compared with Vietnamese standards and pollution indices (geo-accumulation index, contamination factor, and pollution load index). Principal component analysis (PCA) …
Health Risk Assessment Of Toxic Metals In Commonly Consumed Salad Leafy Vegetables In Bangkok, Zin Htoo Hlyan
Health Risk Assessment Of Toxic Metals In Commonly Consumed Salad Leafy Vegetables In Bangkok, Zin Htoo Hlyan
Chulalongkorn University Theses and Dissertations (Chula ETD)
The objectives of this study were 1) to investigate concentrations of toxic metals including As, Cd, and Pb in the commonly consumed salad leafy vegetables which were sold in Bangkok, and 2) to assess potential human health risks of As, Cd, and Pb exposure via salad leafy vegetables consumption. A total of 120 samples were randomly collected from local fresh markets in Bangkok. The total concentrations of toxic metals were determined by an inductively coupled plasma mass spectroscopy (ICP-MS). Total concentrations of As, Cd and Pb in coral lettuce (CL), red coral (RC) and green oak (GO) for soil cultivation …
The Application Of Machine Learning In Clustering Borderline Mild Cognitive Impairment Among Aging Thai People Living With Hiv, Akarin Hiransuthikul
The Application Of Machine Learning In Clustering Borderline Mild Cognitive Impairment Among Aging Thai People Living With Hiv, Akarin Hiransuthikul
Chulalongkorn University Theses and Dissertations (Chula ETD)
Many people living with HIV (PLWH) have cognitive impairment. Details of cognitive impairment subtypes are lacking. Unsupervised machine learning (ML) can reveal hidden subgroups within heterogeneous data. The study aimed to determine clusters of aging Thai PLWH with borderline cognitive impairment using unsupervised ML. HIV-NAT 207 study enrolled Thai PLWH aged ≥50 years. Cognitive performance was evaluated by the Thai-validated Montreal Cognitive Assessment (MoCA). This study included participants who scored between 23 and 27. The score of each cognitive domain served as cluster variables for the K-means algorithm. Among 340 PLWH, 177 (52.1%) scored between 23 and 27. Median age …
Effective Traffic Signal Timing For Intersections In Bangkok, Kasidech Tantipanichaphan
Effective Traffic Signal Timing For Intersections In Bangkok, Kasidech Tantipanichaphan
Chulalongkorn University Theses and Dissertations (Chula ETD)
The increasing number of on-road vehicles in Bangkok, as well as the traffic flow conditions, are causing many problems for the citizens. To alleviate the problem, effective traffic signal management by optimizing traffic signal timing can be used. As a result, the goal of this research is to improve Bangkok's traffic signal system and management by establishing an effective green light time at intersections in order to increase the vehicle flow rate. The mathematical model is designed to maximize the number of vehicles leaving intersections. Six Bangkok intersections are selected for the experiments. According to the experimental results, the optimization …
Spray Dried Asiatic Acid-Palm Oil Nanoemulsion With Improved Characteristics And Antihypertensive Effect Study In Rat Model Of Hypertension, Aditya Trias Pradana
Spray Dried Asiatic Acid-Palm Oil Nanoemulsion With Improved Characteristics And Antihypertensive Effect Study In Rat Model Of Hypertension, Aditya Trias Pradana
Chulalongkorn University Theses and Dissertations (Chula ETD)
Hypertension is a risk factor for premature death worldwide.It is characterized by an increase in blood pressure, so it needs therapy to regulate it and keep the value normal. Asiatic acid (AA) and palm oil (PO) were alternative antihypertensive agents that were promising to be developed. Both were natural compounds obtained from the Centella asiatica and Elaesis guineensis plants. However, low solubility, low absorption, rapid metabolism, low bioavailability and high oxidation were the limitation for both of them as an active compounds. Thus, a combination of nanoemulsion formulation and drying with a spray dryer was necessary to improve the physicochemical …
Assessments Of Chromium Pollution In Surface Sediment Of The Inner Gulf Of Thailand, Patcha Leelakun
Assessments Of Chromium Pollution In Surface Sediment Of The Inner Gulf Of Thailand, Patcha Leelakun
Chulalongkorn University Theses and Dissertations (Chula ETD)
The inner Gulf of Thailand is an important marine resource for economic and social developments of Thailand. Moreover, the inner Gulf of Thailand is a diverse of biological coastal ecosystem, which is make an equilibrium marine environment. On the other hand, this area is due mainly to a variety of pollutant sources from the surface runoff, particularly major large rivers including the Mae Klong, the Tha Chin, the Chao Phraya and the Bangpakong Rivers. As a result, chromium contamination can occur in the inner Gulf of Thailand and ultimately become a serious environmental issue in Thailand. Therefore, the surface sediments …
Evaluation Of Cadmium Bioaccumulations In Pak Choi Grown By Hydroponics System, Piyachet Jinsart
Evaluation Of Cadmium Bioaccumulations In Pak Choi Grown By Hydroponics System, Piyachet Jinsart
Chulalongkorn University Theses and Dissertations (Chula ETD)
Cadmium is one of the most harmful heavy metals reported to contaminate the food chain and pose a high risk for health, including non-carcinogenic and carcinogenic effects. High levels of cadmium contamination due to industrial effluent discharge have been reported to affect plant growth and productivity, which could be used as a bio-indicator for cadmium bioaccumulation in plants. The utilization of cadmium-contaminated water for vegetable production has been known to increase the health risk for human consumption. Moreover, pH level was known as a factor affecting cadmium solubility and cadmium uptake by plants. However, there is still unknown about critical …
Influence Of Seasonal Variations On Contamination Level And Ecological Risk Of Heavy Metals In The Surface Sediments Of The Inner Gulf Of Thailand, Phuttiphat Lapat-Atiwat
Influence Of Seasonal Variations On Contamination Level And Ecological Risk Of Heavy Metals In The Surface Sediments Of The Inner Gulf Of Thailand, Phuttiphat Lapat-Atiwat
Chulalongkorn University Theses and Dissertations (Chula ETD)
The Inner Gulf of Thailand is a marine resource that provides ecological and economic value. Meanwhile, its can be acted like pollutions sink, especially heavy metals. After that, the extensions of industrialization, agriculturalization, and urbanization can degenerate to the inner Gulf environment quality. Therefore, this thesis was aimed to study the spatial distribution and seasonal variation of heavy metal concentration (Cd, Pb, Cu, Co, Ni, Mn and Zn) in surface sediment including the Mae Klong, the Tha Chin, the Chao Phraya and the Bangpakong River estuaries. Moreover, the contamination status and ecological risk were also evaluated. The results shown the …
Investigation Of Copper And Zinc Contaminations In Bioponic Systems Using Chicken Manure Fertilizer, Satja Aksorn
Investigation Of Copper And Zinc Contaminations In Bioponic Systems Using Chicken Manure Fertilizer, Satja Aksorn
Chulalongkorn University Theses and Dissertations (Chula ETD)
The bioponic system is a system that utilizes biological waste as a nutrient-rich source such as chicken manure fertilizer for plant growth integrated with aquaponic. At present, chicken manure fertilizer is contaminated with Cu and Zn may have the potential health effects through vegetable consumption. The objective of this study was to evaluate nitrogen transformation, nitrogen recovery, and plant growth in chicken manure-based bioponics at Cu (50–150 mg/kg) and Zn (200–600 mg/kg) supplementation and investigate the effects of Cu and Zn supplementations on plant bioaccumulation, root microbial community, and dietary health risk. Cu and Zn concentrations were analyzed using inductively …
Ecological Risk Assessment Of Microplastics And Heavy Metals In Central Industrial Wastewater Treatment Plant, Thamonwan Phuprasert
Ecological Risk Assessment Of Microplastics And Heavy Metals In Central Industrial Wastewater Treatment Plant, Thamonwan Phuprasert
Chulalongkorn University Theses and Dissertations (Chula ETD)
Microplastics become a big concern in environment. Their small particle size can absorb a variety of pollutants from the nearby environment when discharged into the environment, especially heavy metals. Central industrial wastewater treatment plant (WWTP) is an important source of microplastics in the environment. In this study, wastewater and sludge were collected from two industrial estates in Thailand. Wastewater was collected from 4 points i.e., influent, post grit chamber, post aeration tank, and post sedimentation tank while sludge was collected from sludge storage. Concentration of microplastics, heavy metals and heavy metals on microplastics were examined to evaluate ecological risk assessment. …
A Study Of Sustainability In The Energy Sector In Myanmar Between 2011 And 2020, Clara Mang Sui Tang
A Study Of Sustainability In The Energy Sector In Myanmar Between 2011 And 2020, Clara Mang Sui Tang
Chulalongkorn University Theses and Dissertations (Chula ETD)
In modern society, energy becomes a life supporting mechanism, as it is not only entangled with the environment pillar of sustainable development, but also inseparably related to the economic and social pillars of society. Taking advantage of a qualitative research method, this study critically examines the level of sustainability of Myanmar’s energy sector between 2011 and 2020, using 2011 as a baseline, by observing three critical components: energy security, environmental considerations in energy production and securing financial health for the sector. Energy security, possessing uninterrupted availability of energy sources at an affordable price, is studied from available macro secondary data …
Queering The Migrant Experience: Gay Filipino Workers’ Performance Of Gender And Sexual Identities In Bangkok, Hans Kevin Madanguit
Queering The Migrant Experience: Gay Filipino Workers’ Performance Of Gender And Sexual Identities In Bangkok, Hans Kevin Madanguit
Chulalongkorn University Theses and Dissertations (Chula ETD)
The Philippine migration scholarship heavily focuses on heteronormative issues that depict the migrant workers as heterosexuals. Due to this trend, there is a scarcity of studies on overseas Filipino workers who identify as part of the Lesbian, Gay, Bisexual, Transgender, and Queer (LGBTQ+) Community. Hence, this qualitative research focuses on eleven documented Filipino workers in Thailand who are males assigned at birth and identify as gay homosexuals. Individual informal interviews were employed to investigate how they practice their non-normative gender and sexuality, given their multiple yet intersectional social identities in a country with vibrant queer cultures. It also probes the …
A Study Of Covid-19 Crisis Communication In Myanmar (January 2020-January 2021) : Divergences Between Ministry Of Health And Sports And State Counsellor, Aye Pa Pa Moe
Chulalongkorn University Theses and Dissertations (Chula ETD)
Effective crisis communication is critical in a country like Myanmar, which has a vulnerable population and a newly democratically elected government. During the COVID-19 pandemic, Myanmar's government established multi communication channels to interact directly with its citizens and other actors, including government agencies, allowing for active stakeholder participation in crisis management. The purpose of this research is to identify the Myanmar government's crisis communication strategy in managing the COVID issue at the national level from January 2020 to January 2021. The study will take a three-stage approach to crisis management, with pre-crisis, crisis, and post-crisis stages. It also explored Myanmar's …
The Motherhood Wage Penalty In The Public And Private Sectors In Thailand, 2017, Qiuge Chen
The Motherhood Wage Penalty In The Public And Private Sectors In Thailand, 2017, Qiuge Chen
Chulalongkorn University Theses and Dissertations (Chula ETD)
Prior research has shown that the Motherhood Wage Penalty on mothers has led to mothers earning a lower monthly income than women without children in Thailand. This paper uses the Social Economic Survey (SES) of 2017 to study how the motherhood penalty affects women from different sectors. Using data of 9522 women from age 15 to 65 in the SES 2017, I find that the average motherhood wage penalty stood at 7.6 percent. The average penalty was 1.6 percent higher in the public sector versus the penalty in the private sector. Human Capital Theory explains the wage gap between mothers …
Gis Mapping Evaluation Of Stroke Service Areas In Bangkok Using Emergency Medical Services, Kiatirat Sreemongkol
Gis Mapping Evaluation Of Stroke Service Areas In Bangkok Using Emergency Medical Services, Kiatirat Sreemongkol
Chulalongkorn University Theses and Dissertations (Chula ETD)
Nowadays, stroke is the leading cause of death in Thailand. Patients must be treated within 4.5 hours from symptom onset to increase recovery rate. Time is therefore a critical factor of the success or failure of the treatments. The objective of this research is to investigate the service coverage of various healthcare centers through current Emergency Medical Services (EMS) in Bangkok. To get service coverages for Stroke in Bangkok, the updated speed of the traffic and the amount of time it takes for each mode of transport for the pre-hospital stroke process are collected and examined using GIS mapping. The …
The Healthcare Information For Patient Referral, Veerawan Aumpanseang
The Healthcare Information For Patient Referral, Veerawan Aumpanseang
Chulalongkorn University Theses and Dissertations (Chula ETD)
Despite the cooperative sharing of Health Information Exchange (HIE), various distinct limitations and barriers are found, i.e., substantial time and resources are being used to achieve health information. This paper aims to investigate the limits of healthcare information sharing policy implementation and assorts the critical and shareable set of relevant healthcare information to patient referral systems in Thailand. Mixed-methods research methodology, both quantitative and qualitative mechanisms are conducted. The study results present the correlation between the current healthcare information exchange among the hospitals in patient referral systems and the limitations of implementing the HIE policy composed of technical, economic, political, …
Effectiveness Of The New Ambulance Air Exhaust System In Reducing Aerosol Particle Concentration, Vasutorn Petrangsan
Effectiveness Of The New Ambulance Air Exhaust System In Reducing Aerosol Particle Concentration, Vasutorn Petrangsan
Chulalongkorn University Theses and Dissertations (Chula ETD)
The objective of this work is to assess the effectiveness in reducing airborne particles of the Camfil® CC410-concealed air exhaust system, that is installed in the ER-1 ambulance (a King Chulalongkorn Memorial Hospital ambulance). This is done by diffusing aerosols into the cabin at the patient’s face position for an injection period (IP) of 1 minute and measuring the aerosol concentration inside the cabin over time. The experiment is conducted for 2 ventilation conditions, when the exhaust system is off (Minimal Ventilation: MV) and at maximum speed (High Ventilation: HV). Density of the aerosol is interpreted in terms of its …
Development Of Novel Point-Of-Care-Testing For Oxalate Detection In Urine Based On Oxalate-Binding Ligands, Naruerat Joybumrung
Development Of Novel Point-Of-Care-Testing For Oxalate Detection In Urine Based On Oxalate-Binding Ligands, Naruerat Joybumrung
Chulalongkorn University Theses and Dissertations (Chula ETD)
Kidney stone disease is the third most common urinary tract disease worldwide that is more prevalent in the tropics. In Thailand, the highest stone prevalence up to 17% is reported in the Northeast. The disease is highly recurrent with a recurrence rate of about 50% within 5-10 years. The most common type of kidney stones is calcium oxalate (CaOx), and an increased urinary oxalate excretion is an important risk factor. Most of kidney stone patients have a hyperoxaluria condition (urinary oxalate >40 mg/day or >0.46 mmol/day). Therefore, urinary oxalate measurement has been widely used for estimating the risk of CaOx …
Epigenetic Regulation Of Reactive Oxygen Species-Induced Tumor Progression In Hepatocellular Carcinoma, Suchittra Phoyen
Epigenetic Regulation Of Reactive Oxygen Species-Induced Tumor Progression In Hepatocellular Carcinoma, Suchittra Phoyen
Chulalongkorn University Theses and Dissertations (Chula ETD)
Oxidative stress is a consequence of an imbalance of antioxidants and reactive species. The most common form of reactive species is derived from oxygen, called reactive oxygen species (ROS). ROS involve in pathogenesis of several diseases including cancers. Cancer genesis and progression are contributed through both genetic and epigenetic mechanisms. Histone modification, a post-translational modification at histone tails, is one of the epigenetic mechanisms known to participate in carcinogenesis and tumor progression. Although the ROS-induced histone modification alteration has been demonstrated in some cancers, the change in histone methylation and gene expression by ROS in hepatocellular carcinoma (HCC) is scarcely …
Integrative Transcriptomic Analysis And Validation Of Non-Coding Rna In Liver Cancers, Varunya Virushkul
Integrative Transcriptomic Analysis And Validation Of Non-Coding Rna In Liver Cancers, Varunya Virushkul
Chulalongkorn University Theses and Dissertations (Chula ETD)
Hepatocellular carcinoma (HCC) and intrahepatic cholangiocarcinoma (iCCA) are the most common and cause cancer-related deaths. Due to the lack of sensitivity and specificity of conventional markers, such as AFP, CA19-9 and CEA. Thus, this study aimed to identify miRNAs as a diagnostic biomarker for HCC and iCCA. First, in discovery set, RNA sequencing and small RNA sequencing data of 992 HCC and adjacent tissues and 116 iCCA and adjacent tissues were downloaded from the GEO database. After that, the lncRNA-miRNA-mRNA network was constructed and analyzed for the differential expression of lncRNA (DElncRNA), miRNA (DEmiRNA), and mRNA (DEmRNA). Then, the significant …
Development Of A Human Viable Heavy Chain Antibody Against The Alpha Folate Receptor As A Molecule For Targeted Application By Phage Display Technology, Nattihda Parakasikron
Development Of A Human Viable Heavy Chain Antibody Against The Alpha Folate Receptor As A Molecule For Targeted Application By Phage Display Technology, Nattihda Parakasikron
Chulalongkorn University Theses and Dissertations (Chula ETD)
Alpha folate receptor (FRα) is currently under investigation as a target for the treatment of patients with non-small-cell lung cancer (NSCLC), since it is highly expressed in tumor cells but is largely absent in normal tissue. In this study, a novel human variable domain of a heavy-chain (VH) antibody fragment specific to FRα was enriched and selected by phage bio-planning. The positive phage clone (3A102 VH) is specifically bound to FRα and also cross-reacted with FRβ, as tested by ELISA. Clone 3A102 VH was then successfully expressed as a soluble protein in an E. coli shuffle strain. The obtained soluble …