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Optimizing Energy Efficiency Projects In Bangkok Large Commercial Buildings, Angelica Arisa Morgan
Optimizing Energy Efficiency Projects In Bangkok Large Commercial Buildings, Angelica Arisa Morgan
Chulalongkorn University Theses and Dissertations (Chula ETD)
As a significant contributor to greenhouse gas emissions in the Asia Pacific region, Thailand has pledged to lower its GHG emissions by 555 million tCO2e by the year 2030. In Bangkok, energy efficiency projects in the large commercial buildings sector are an integral method by which to reduce emissions and to support a lower carbon future. Besides carbon dioxide emissions, energy efficiency projects also have the potential for other benefits including electricity and cost savings. This study develops a methodology to quantify the emissions reduction, electricity savings, and cost savings potential of various energy efficiency methods in this sector, and …
Forecasting Cane Sugar Production Under Climate Change And Human-Ecotoxicological Impact, Arisara Tachabunya
Forecasting Cane Sugar Production Under Climate Change And Human-Ecotoxicological Impact, Arisara Tachabunya
Chulalongkorn University Theses and Dissertations (Chula ETD)
This study forecasted sugar cane yield and cane sugar production using stepwise multiple linear regression (MLR) and autoregressive integrated moving average (ARIMA). Then, impacts on human health and ecosystems at the endpoint level were evaluated using openLCA software version 1.10.3 and the ReCiPe 2016 method. The functional units were the production of 1 kg raw sugar, 1 kg granulated sugar, and 1 kg refined sugar at Tamaka Sugar Industry Co., Ltd., Kanchanaburi province, Thailand. The result revealed that relative humidity at the Thong Pha Phum meteorological station, maximum temperature at the Kanchanaburi meteorological station, and oceanic Niño Index (ONI) were …
Influence Of Tidal Current On Microplastic Dynamics In Chao Phraya River Estuarine Ecosystem, Jiradet Tang-Siri
Influence Of Tidal Current On Microplastic Dynamics In Chao Phraya River Estuarine Ecosystem, Jiradet Tang-Siri
Chulalongkorn University Theses and Dissertations (Chula ETD)
Microplastics (MPs) can be found almost everywhere in marine ecosystems. That is one of the issues of concern around the world, including in Thailand. Estuary ecosystems are also among the most disturbed. By the estuary ecosystem affected by both rivers and oceans, such as the mouth of the Chao Phraya River in Thailand. Due to the change in tide, it is necessary to study the effects of tidal currents on the depth of MPs. Water samples were collected at approximately 60 water levels in 24 hours. Samples and three water quality indicators were collected at Pak Nam Chao Phraya. The …
Wastewater-Based Epidemiology And Quantitative Microbial Risk Assessment Associated With Wastewater Contact Of Norovirus In Bangkok, Thailand, Nonnarit Sriporatana
Wastewater-Based Epidemiology And Quantitative Microbial Risk Assessment Associated With Wastewater Contact Of Norovirus In Bangkok, Thailand, Nonnarit Sriporatana
Chulalongkorn University Theses and Dissertations (Chula ETD)
Norovirus is one of the leading causes of acute gastroenteritis worldwide. Wastewater surveillance offer significant benefits such as enhancing our understanding of the disease occurrence in the population, evaluating the effectiveness of pathogen reduction in the treatment process, and tracking the spread of pathogens in the environment which pose a health risk to humans. Hence, wastewater surveillance is crucial. In this study, the influent and effluent samples were collected bi-monthly from March 2020 to March 2021 from three distinct wastewater treatment plants in Bangkok. Wastewater samples were concentrated and subjected to quantitative polymerase chain reaction (qPCR) to assess norovirus concentrations. …
Southeast Asian Ministers Of Education Organization (Seameo) 'S Role In Digitalisation For Vocational Education Development : A Comparative Analysis Of Indonesia And Thailand, Anastasia Sylvia
Chulalongkorn University Theses and Dissertations (Chula ETD)
This thesis focuses on the role of the SEAMEO (Southeast Asian Ministers of Education Organization) role in vocational education development in Industry 4.0. Nowadays, there is a demand for the education sector to align with Industry 4.0, known as Education 4.0. In 2018, the SEAMEO, in collaboration with the GIZ, launched a Regional In-Service Training Modules project to support vocational education for Education 4.0. This study compares the impact of the Regional In-Service Training Modules project in two countries with a medium level of education performance in Southeast Asia: Indonesia and Thailand. This study employs a qualitative method with a …
Climate Imaginaries And Human Mobility: Complicating Climate Mobility As Adaptation In Thailand, Clare Steiner
Climate Imaginaries And Human Mobility: Complicating Climate Mobility As Adaptation In Thailand, Clare Steiner
Chulalongkorn University Theses and Dissertations (Chula ETD)
For centuries, agricultural households in Thailand have engaged in mobility to adapt to environmental change and climate shocks. However, current framings of “climate migration as adaptation” obscure how these adaptation pathways are constructed by existing power relations, leaving institutions liable to re-enforce inequality. This thesis uses the concept of “imaginaries” to de-construct how certain knowledge and values advance over others in the process of negotiating and acting towards a preferable future. It employs a dual methodological approach with a case study of Baan Non Daeng in Ubon Ratchathani, Thailand to analyze dominant imaginaries in Thailand and their function and limitations …
Unpacking Gender Inequality For Inclusive Development: A Case Study Of Myanmar Female Migrant Workers In Samut Sakhon Province, Thailand, Hsan Thawdar Htun
Unpacking Gender Inequality For Inclusive Development: A Case Study Of Myanmar Female Migrant Workers In Samut Sakhon Province, Thailand, Hsan Thawdar Htun
Chulalongkorn University Theses and Dissertations (Chula ETD)
The study aims to address the issue of gender inequality in Thailand's seafood industry, with a specific focus on Myanmar female migrant workers in Mahachai (Samut Sakhon province). Although women migrant workers play a significant role in Thailand's economy, they have been facing various challenges in low-wage industries. Gender inequality remains a prominent concern in these low-skilled labor-intensive workplaces like seafood industry. While there have been studies on migration that include both men and women or focus solely on women, gender has not received sufficient emphasis in understanding the experiences of female migrant workers, particularly in the seafood industry. This …
Migrant Trainees And Social Inclusion : A Study Of Construction And Electronics Company In Japan, Kazuhiro Watanabe
Migrant Trainees And Social Inclusion : A Study Of Construction And Electronics Company In Japan, Kazuhiro Watanabe
Chulalongkorn University Theses and Dissertations (Chula ETD)
This research analyzed the Technical Intern Training Program (TITP) by using the concept of social inclusion and discussed the factors that inhibit the social inclusion of trainees. Not much previous research on has been done on this because trainees are allowed to stay in Japan temporarily and they must go back to their home countries after the training is over. However, trainees contribute economic growth in Japan and play an important role for solving issues of the labor force. Realizing social inclusion of trainees is thus a significant issue for Japan. Factors that inhibit the social inclusion of trainees includes …
Intersectionality And Livelihoods Of Conflict-Induced Displaced Myanmar Women In Mae Sot, Thailand, Su Myat Thwe
Intersectionality And Livelihoods Of Conflict-Induced Displaced Myanmar Women In Mae Sot, Thailand, Su Myat Thwe
Chulalongkorn University Theses and Dissertations (Chula ETD)
The Sustainable Development Goals Report (2022) highlighted the global displacement crisis as 24.5 million population impacted by conflict by mid-2021; 311 out of every 100,000 people worldwide seeking refuge outside their country of origin[1]. The cycle of migration to Thailand from Myanmar has a special history with many intersecting factors of forced migration and a new trend emerges following 1st February 2021: only 1,527 cases in 9 shelters[2]; 986,670 regularized as migrant workers in 2021[3]; tens of thousands of unrecorded. The role of Myanmar’s unsung heroines cannot go forgotten. From a sociocultural conservative country with a constitution drafted by a …
Assessing The Contribution Of Thailand’S Poultry Agribusiness Towardsmitigating Climate Change, Tita Phairaksa
Assessing The Contribution Of Thailand’S Poultry Agribusiness Towardsmitigating Climate Change, Tita Phairaksa
Chulalongkorn University Theses and Dissertations (Chula ETD)
This research provides an overview of the Thailand agreement on greenhouse gas emissions, specifically focusing on the meat industry, and examines the roles of the government, private companies, and civil society in Thailand. Research indicates that the meat industry has significant environmental impacts, including greenhouse gas emissions, deforestation, and biodiversity loss. Livestock for meat consumption has been a major contributor to environmental issues such as climate change, water pollution, and deforestation. Livestock alone contributes a substantial percentage to global climate change. This issue has become a critical transboundary concern affecting not only one specific country or region. In response to …
A Study On Government Lottery Buying Behavior : The Cases Of Thai Consumers In Bangkok And Korean Consumers In Seoul Using Online Questionnaire, Korakoj Tongboriboon
A Study On Government Lottery Buying Behavior : The Cases Of Thai Consumers In Bangkok And Korean Consumers In Seoul Using Online Questionnaire, Korakoj Tongboriboon
Chulalongkorn University Theses and Dissertations (Chula ETD)
The research investigates the important factors influencing the government’s lottery buying behavior. The objectives of this research are to study the behavior of the lottery consumers between Thai and Korean consumers. The number of participants of Thai and Korean consumers should be separated. Among the total of 864 consumers, 445 consumers are Thai and the other 419 are Korean. This research employs a quantitative research design, and the data is collected by a questionnaire as a research tool. The data is statistically analyzed by percentage, means, standard deviation, Chi-square and Logistic Regression.The results show that the differences between Thai and …
The Influence Of K-Pop Thai Fan Loyalty On The Image Of Korean Male Idol: A Case Study Of Lim Youngmin, Nattanon Wongsantimeth
The Influence Of K-Pop Thai Fan Loyalty On The Image Of Korean Male Idol: A Case Study Of Lim Youngmin, Nattanon Wongsantimeth
Chulalongkorn University Theses and Dissertations (Chula ETD)
K-pop boyband artist AB6IX from South Korea, Lim Youngmin, has won the hearts of Thai fans that have developed into loyalness to him. However, Lim Youngmin has faced situations that affected the artist's idol image, and this resulted in the inability of performing as an artist in the meantime, from an incident in 2020, after being arrested for DUI - driving under the influence of alcohol. He had his driving license revoked in the same year which might force him to decide to enlist himself in the military, which is a requirement for all male citizens of South Korea without …
Household Characteristics Of Indebted Households With Members Working In The Public And Private Sector, Kawita Niwatananun
Household Characteristics Of Indebted Households With Members Working In The Public And Private Sector, Kawita Niwatananun
Chulalongkorn University Theses and Dissertations (Chula ETD)
The research analyzed the influence of different household characteristics on household debt, including mortgage debt. Using data from Thailand’s Household Socio-Economic Survey in 2019 and 2021, the study implemented a logit model to identify household characteristics with significant impact on household debt. By analyzing data from two different periods that varied in social and economic contexts, the study highlighted critical factors that influenced household debt demand. The datasets were divided into three categories according to household work status. The categories include households with at least one public sector worker, households with no public sector workers but at least one private …
Exploring Roles Of Mir-885-5p In Hepatocellular Carcinoma, Archittapon Nokkeaw
Exploring Roles Of Mir-885-5p In Hepatocellular Carcinoma, Archittapon Nokkeaw
Chulalongkorn University Theses and Dissertations (Chula ETD)
Hepatocellular carcinoma (HCC), the most prevalent form of liver cancer, exerts a significant burden on Southeast Asian countries and stands as the third leading cause of cancer-related mortality worldwide. Despite this alarming impact, effective treatments for HCC are lacking, resulting in low survival rates and high recurrence rates. Therefore, a comprehensive understanding of the disease's underlying mechanisms is crucial for the development of novel and potent therapies. Recently, it has been recognized that microRNAs (miRNAs) play a vital role in tumorigenesis, including HCC. Our bioinformatic analysis has highlighted hsa-miR-885-5p as a potential candidate miRNA due to its downregulation in HCC …
Exploring Roles Of Mir-372-3p In Proliferation Of Hepatocellular Carcinoma Cells, Pannathon Thamjamrassri
Exploring Roles Of Mir-372-3p In Proliferation Of Hepatocellular Carcinoma Cells, Pannathon Thamjamrassri
Chulalongkorn University Theses and Dissertations (Chula ETD)
Hepatocellular carcinoma (HCC) is the most common type of primary liver cancer. HCC has a replicative immortality and sustained proliferation rate. In addition, cell cycle-related protein regulating proliferation in cancer are often found dysregulated, allowing cancer cells to proceed their proliferation uncontrollably. Recently, a small non-coding RNA, microRNA (miRNA), was found to play an important role in numerous biological functions. Specific miRNA may ameliorate or promote cancer progression through different target mRNA. MiR-372-3p has been explored in various cancers such as colon cancer, colorectal cancer, and glioma. However, its functions have been rarely studied in HCC, especially in the aspect …
Classification Of Bacteria And Fungi In Peritoneal Dialysis Fluids Of Patients With Chronic Kidney Disease Based On Metagenomic Analysis, Suthida Visedthorn
Classification Of Bacteria And Fungi In Peritoneal Dialysis Fluids Of Patients With Chronic Kidney Disease Based On Metagenomic Analysis, Suthida Visedthorn
Chulalongkorn University Theses and Dissertations (Chula ETD)
Chronic kidney disease (CKD) is a long-term condition where sustained damage of the renal parenchyma leads to the chronic deterioration of renal function that may gradually progress to end-stage kidney disease (ESKD). Peritoneal dialysis (PD) is a type of ESKD treatment that is beneficial to improve a patient's quality of life. However, PD-associated peritonitis is a major complication that contributes cause of death, and the detection of the pathogen provided a high culture-negative rate. This study aims to apply metagenomic approaches for identifying the bacteria and fungi in peritoneal dialysis effluent (PDE) of CKD patients based on the full-length 16S …
Effects Of Chitosan Oligosaccharide And Probiotics On Chronic Kidney Disease Rats, Weerapat Anegkamol
Effects Of Chitosan Oligosaccharide And Probiotics On Chronic Kidney Disease Rats, Weerapat Anegkamol
Chulalongkorn University Theses and Dissertations (Chula ETD)
Chronic kidney disease (CKD) patients suffer from the accumulation of toxic substances in their blood due to the loss of kidney function, which results in hyperphosphatemia. This condition contributes to hyperparathyroidism, leading to the development of chronic kidney disease-related mineral bone disorder (CKD-MBD). Additionally, CKD patients experience changes in their gut microbiota, disrupting epithelial tight junctions and allowing excessive absorption of dietary phosphate. In this study, we aimed to investigate the effects of various oligosaccharides and probiotics on the gut microbiota, intestinal barrier, hyperphosphatemia, and hyperparathyroidism in CKD rats. We isolated Lactobacillus and Bifidobacterium strains from healthy participants and tested …
Effects Of Different Serum Supplements On Piggybac Cd19 Chimeric Antigen Receptor T Cells, Mulita Sanyanusin
Effects Of Different Serum Supplements On Piggybac Cd19 Chimeric Antigen Receptor T Cells, Mulita Sanyanusin
Chulalongkorn University Theses and Dissertations (Chula ETD)
Chimeric Antigen Receptor (CAR) T cell is a novel therapy for relapse and refractory hematologic malignancy. Characteristics of CAR T cells is associated with clinical efficacy and toxicity. Type of serum supplements used during cultivation affect the immunophenotype and function of viral-based CAR T cells. This study explores the effect of serum supplements on non-viral piggyBac transposon CAR T cell production. PiggyBac CD19 CAR T cells were expanded in cultured conditions containing either fetal bovine serum, human AB serum, human platelet lysate or xeno-free serum replacement. Then, the effect of different serum supplements on cell expansion, transfection efficiency, immunophenotypes and …
The Effect Of Histone Methylation In Trained Innate Immunity Of Cord Blood Monocytes In Newborn Infants Of Chronic Hbv-Infected Mothers, Pennapa Plypongsa
The Effect Of Histone Methylation In Trained Innate Immunity Of Cord Blood Monocytes In Newborn Infants Of Chronic Hbv-Infected Mothers, Pennapa Plypongsa
Chulalongkorn University Theses and Dissertations (Chula ETD)
Newborns contract Hepatitis B virus (HBV) through exposure in utero from mothers who are infected with HBV. In newborn infant from chronic HBV-infected mothers, the immune system displays innate immune cell maturation and enhances immune response upon restimulation with unrelated pathogens such as bacteria. This pattern is called “trained immunity” or “innate immune memory”. Trained immunity is regulated by epigenetic programming, especially histone modification. To date, there is not report on the epigenetics to regulate trained immunity in HBV. Therefore, this study investigated the cytokines levels and expression levels of histone modification enzyme genes in HBV-exposed cord blood monocytes. Moreover, …
Study Of Thermodynamic Binding Between Ader And Ades In Two-Component Antibiotic Sensor Of Antibiotic Resistant Strains Of Acinetobacter Baumannii, Konrawee Thananon
Study Of Thermodynamic Binding Between Ader And Ades In Two-Component Antibiotic Sensor Of Antibiotic Resistant Strains Of Acinetobacter Baumannii, Konrawee Thananon
Chulalongkorn University Theses and Dissertations (Chula ETD)
The proteins AdeR (response regulator) and AdeS (histidine kinase sensor) play a crucial role in regulating the efflux pump, which is responsible for removing antibiotics from bacterial cells. This regulation occurs through a two-component regulatory system (TCS) involving autophosphorylation. Upon receiving external signals, AdeS undergoes autophosphorylation, leading to the activation of AdeR, which in turn initiates the expression of target genes related to the efflux pump. In this study, both enzymes from the reference strain of Acinetobacter baumannii (ATCC19606) and antibiotic resistant strains (H1074 and G560) were cloned and expressed in E. coli. The enzymes were purified using an immobilized …
Macrophage Depletion Enhances Gut Dysbiosis And Severity In Sepsis Mouse Model, Pratsanee Hiengrach
Macrophage Depletion Enhances Gut Dysbiosis And Severity In Sepsis Mouse Model, Pratsanee Hiengrach
Chulalongkorn University Theses and Dissertations (Chula ETD)
Macrophage is vital players in the responsiveness of the innate immune system against injury or infection. Although macrophage depletion is well-known for some emerging therapies, such as osteoporosis, osteopenia, and decreasing tumor-associated macrophages in melanoma, dysfunction of macrophages leads to an inability of an appropriate immune response and implicated in various disease processes, especially intestinal macrophages that play a key role in the gut immune system and the regulation of gastrointestinal physiology. To obtain an understanding of the role of sepsis-associated macrophages, clodronate was used for the dysfunction of mouse macrophages with and without cecal ligation and puncture (CLP) sepsis. …
Epigenetic Regulation In Trained And Tolerized Macrophages, Salisa Benjaskulluecha
Epigenetic Regulation In Trained And Tolerized Macrophages, Salisa Benjaskulluecha
Chulalongkorn University Theses and Dissertations (Chula ETD)
Innate immune memory is the phenomenon that can either enhance (trained) or suppress (tolerized) immune response by innate immune cells during the second encounter of the stimuli such as pathogens. Previous studies reported that epigenetic regulations critically regulate both types of innate immune memory. However, a complete understanding of the underlying mechanisms is still lacking. In this study, we performed a screening of an epigenetics compound library to identify inhibitors that affect ß-glucan (BG)-trained or LPS-tolerized macrophages. Among 181 compounds tested, various inhibitors targeting Aurora kinase, histone methyltransferase PRMT and EZH2, histone demethylase LSD1 and JMJD2, histone deacetylase 6 and …
In Vivo Dosimetry Of 3d Gynecological Brachytherapy Using The Glass Dosimeter: A Phantom Study, Itsaraporn Konlak
In Vivo Dosimetry Of 3d Gynecological Brachytherapy Using The Glass Dosimeter: A Phantom Study, Itsaraporn Konlak
Chulalongkorn University Theses and Dissertations (Chula ETD)
Brachytherapy can deliver high doses to the target while sparing healthy tissues due to its steep dose gradient property. However, treatment was only performed according to the dose calculated by a treatment planning system without verification of the dose due to the characteristics. Therefore, the aim of this study was to design the in-house phantom to evaluate the dosimetric differences of gynecological brachytherapy under clinical conditions between calculation by the treatment planning system and measurement by the RPLGDs. An in-house phantom consisting of the glass dosimeter holder and the holder of the applicator was created. This holder was designed to …
Effect Of Inter-Observer Delineation Variability On Radiomics Features In Nasopharyngeal Cancer, Pongpitch Panyura
Effect Of Inter-Observer Delineation Variability On Radiomics Features In Nasopharyngeal Cancer, Pongpitch Panyura
Chulalongkorn University Theses and Dissertations (Chula ETD)
Nasopharyngeal cancer (NPC) is a type of head and neck cancer that is prevalent in China and Southeast Asia. The standard treatment for NPC is radiation therapy (RT), which requires accurate target volume delineation (TVD) to ensure an effective radiation dose while minimizing damage to surrounding healthy tissues. However, TVD is subject to intra- and inter-observer variability, which can affect the accuracy of RT and lead to unstable results in radiomics analysis. Radiomics is a technique that extracts quantitative data from medical images, but it is currently limited by the manual process of tumor delineation. This study aims to investigate …
Dosimetric Differences Between Scheduled And Adapted Plans Generated From Ethos Adaptive Radiotherapy For Patients With Prostate Cancer, Sarita Suvira
Dosimetric Differences Between Scheduled And Adapted Plans Generated From Ethos Adaptive Radiotherapy For Patients With Prostate Cancer, Sarita Suvira
Chulalongkorn University Theses and Dissertations (Chula ETD)
Prostate is one of the organs that can easily move or change during the treatment fractions. Adaptive radiotherapy can help to reduce the uncertainty of interfraction and decrease the side effects produced from the radiation given to the patients. The objective of this study was to provide evidence of the efficiency of adaptive radiotherapy for prostate cancer patients by investigating the dosimetric differences between the scheduled and adapted plans generated from Ethos. The treatment data of 100 fractions of prostate cancer patients who had previously been treated on Ethos daily adaptive radiotherapy were collected. The treatment data in each fraction …
Accuracy In Classification Of Liver Lesion Ultrasound Using Artificial Intelligence, Sutthirak Tangruangkiat
Accuracy In Classification Of Liver Lesion Ultrasound Using Artificial Intelligence, Sutthirak Tangruangkiat
Chulalongkorn University Theses and Dissertations (Chula ETD)
B-mode ultrasound imaging is the standard method for hepatocellular carcinoma (HCC) screening. If a lesion has a unique appearance, a conventional detector can be applied. However, if the lesion shares its appearance with other lesion, a large training dataset is required, which may be unavailable. Therefore, a two-stage method is proposed. In the first stage, lesions are detected but not differentiated into any particular class. The detected lesions are then classified in the second stage using a conventional convolutional neural network (CNN). The aims of the dissertation are to design an artificial intelligent system model and to investigate the most …
Accuracy Of Small-Field High Energy Photon Using Plastic Scintillation Detector In Heterogenous Media Compared With Model-Based Algorithm Calculation, Thanat Kaewsuksri
Accuracy Of Small-Field High Energy Photon Using Plastic Scintillation Detector In Heterogenous Media Compared With Model-Based Algorithm Calculation, Thanat Kaewsuksri
Chulalongkorn University Theses and Dissertations (Chula ETD)
Some radiotherapy techniques such as stereotactic body radiotherapy (SBRT) has the challenges in small field dosimetry in heterogenous media. This study aims at evaluating the accuracy of W2 plastic scintillation detector (PSD) compared with the calculation from algorithms for small-field high energy photon in heterogenous media. The characteristics of W2-PSD were studied. The percentage depth dose (PDD) of 6 FFF and 10 FFF with various field sizes ranging from 1x1 to 4x4 cm2 were measured in solid water phantom with low-density inhomogeneities slabs of air (Styrofoam) and lung (cork) and high-density inhomogeneity slab of aluminum. The characteristics of W2 plastic …
Regulatory T Cell In Drug-Induced Severe Cutaneous Adverse Reactions (Scars) During Acute And Recovery Phase, Suparada Khanaruksombat
Regulatory T Cell In Drug-Induced Severe Cutaneous Adverse Reactions (Scars) During Acute And Recovery Phase, Suparada Khanaruksombat
Chulalongkorn University Theses and Dissertations (Chula ETD)
Drug reaction with eosinophilia and systemic symptoms (DRESS) is a type of SCARs induced by various drugs. The autoimmune consequences were observed throughout the recovery phase ranging between 10 – 20 % of DRESS patients. The dynamics of regulatory T cells (Tregs) are thought to be responsible for the many symptoms of DRESS. They may be a key player in developing autoimmune sequelae in this syndrome. This study concentrated on the number and function of CD4+CD25+CD127-FoxP3+ Tregs in autoimmune development in DRESS patients. CD4+CD25+CD127-FoxP3+ Tregs and their immunophenotyping were characterized using peripheral blood mononuclear cells (PBMCs) from patients by Flow …
Analysis Of Vocs From Exhaled Breath For The Diagnosis Of Hepatocellular Carcinoma, Thanikarn Suk-Aram
Analysis Of Vocs From Exhaled Breath For The Diagnosis Of Hepatocellular Carcinoma, Thanikarn Suk-Aram
Chulalongkorn University Theses and Dissertations (Chula ETD)
Background: Volatile organic compounds (VOCs) were shown as promising biomarkers for hepatocellular carcinoma (HCC) diagnosis. We aimed to investigate the performance of VOCs for diagnosing early-stage HCC in patients at-risk for HCC. Methods: VOCs were identified in exhaled breath samples collected from 90 early-stage HCC patients, 90 cirrhotic patients, 91 HBV-infected patients, and 95 healthy volunteers using thermal desorption-gas chromatography/field-asymmetric ion mobility spectrometry. The VOC levels were compared between the four groups. An association between VOCs and HCC was determined using logistic regression analysis. Diagnostic performance of VOCs was estimated using the AUROC and compared to serum alpha-fetoprotein (AFP). Results: …
The Association Of Genetic Variations In Pnpla3, Tm6sf2 And Hsd17b13 Genes In Non-Alcoholic Fatty Liver Disease Patients With And Without Hiv Infection., Varis Ruamviboonsuk
The Association Of Genetic Variations In Pnpla3, Tm6sf2 And Hsd17b13 Genes In Non-Alcoholic Fatty Liver Disease Patients With And Without Hiv Infection., Varis Ruamviboonsuk
Chulalongkorn University Theses and Dissertations (Chula ETD)
Non-alcoholic liver disease (NAFLD) has multiple risk factors, including genetic risk factors. Patients with certain genetic variants are more susceptible to the disease. People living with HIV (PLWH) have higher prevalence of NAFLD compared to those without HIV infection. But, the evidence on genetic factors in PLWH with NAFLD is limited. We aim to investigate whether carriers of PNPLA3 rs738409, TM6SF2 rs58542926, and HSD17B13 rs6834314 had association with the risk of NAFLD, and whether PLWH with NAFLD also had similar genetic risk factors as those with NAFLD alone. These SNPs were determined by using allelic discrimination in blood samples of …