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Articles 931 - 960 of 20026
Full-Text Articles in Entire DC Network
Automatic Classification Of 10 Blood Cell Subtypes Using Transfer Learning Via Pre-Trained Convolutional Neural Networks, Rabia Asghar, Sanjay Kumar, Paul Hynds
Automatic Classification Of 10 Blood Cell Subtypes Using Transfer Learning Via Pre-Trained Convolutional Neural Networks, Rabia Asghar, Sanjay Kumar, Paul Hynds
Articles
Human blood is primarily composed of plasma, red blood cells, white blood cells, and platelets. It plays a vital role in transporting oxygen and nutrients to all organs, and stores essential health-related data about the human body. Blood cells are utilized to defend the body against infections and disease. Hence, analysis of blood permits physicians to assess an individual's physiological condition. Blood cells are sub-classified into eight groups: Neutrophils, eosinophils, basophils, lymphocytes, monocytes, immature granulocytes (promyelocytes, myelocytes, and metamyelocytes), erythroblasts, and platelets (thrombocytes) on the basis of their nucleus, shape and cytoplasm. Traditionally, pathologists and hematologists have identified and examined …
Influence Of Seasonality And Public-Health Interventions On The Covid-19 Pandemic In Northern Europe, Gerry A. Quinn, Michael Connolly, Norman E. Fenton, Steven J. Hatfill, Paul Hynds, Coilín Óhaiseadha, Karol Sikora, Willie Soon, Ronan Connolly
Influence Of Seasonality And Public-Health Interventions On The Covid-19 Pandemic In Northern Europe, Gerry A. Quinn, Michael Connolly, Norman E. Fenton, Steven J. Hatfill, Paul Hynds, Coilín Óhaiseadha, Karol Sikora, Willie Soon, Ronan Connolly
Articles
Background: Most government efforts to control the COVID-19 pandemic revolved around non-pharmaceutical interventions (NPIs) and vaccination. However, many respiratory diseases show distinctive seasonal trends. In this manuscript, we examined the contribution of these three factors to the progression of the COVID-19 pandemic. Methods: Pearson correlation coefficients and time-lagged analysis were used to examine the relationship between NPIs, vaccinations and seasonality (using the average incidence of endemic human beta-coronaviruses in Sweden over a 10-year period as a proxy) and the progression of the COVID-19 pandemic as tracked by deaths; cases; hospitalisations; intensive care unit occupancy and testing positivity rates in six …
Development Of A “Big Data” Groundwater Microbial Contamination Index And Spatial Comparisons With Enteric Infection Rates In Southern Ontario, Ioan Petculescu, Paul Hynds, R. Stephen Brown, Martin Boudou, Kevin Mcdermott, Anna Majury
Development Of A “Big Data” Groundwater Microbial Contamination Index And Spatial Comparisons With Enteric Infection Rates In Southern Ontario, Ioan Petculescu, Paul Hynds, R. Stephen Brown, Martin Boudou, Kevin Mcdermott, Anna Majury
Articles
Big data have become increasingly important for policymakers and scientists but have yet to be employed for the development of spatially specific groundwater contamination indices or protecting human and environmental health. The current study sought to develop a series of indices via analyses of three variables: Non-E. coli coliform (NEC) concentration, E. coli concentration, and the calculated NEC:E. coli concentration ratio. A large microbial water quality dataset comprising 1,104,094 samples collected from 292,638 Ontarian wells between 2010 and 2021 was used. Getis-Ord Gi* (Gi*), Local Moran's I (LMI), and space-time scanning were employed for index development based on identified cluster …
The Use Of E. Coli Phylogrouping And Microbial Source Tracking (Non-Species Specific, Human-Specific, Bovine-Specific Bacteroidales Markers) To Elucidate Hydro(Geo)Logical Contamination Mechanisms In Southeastern Ontario, Canada, Madeleine Kelly, Paul Hynds, R. Stephen Brown, Kevin Mcdermott, Ioan Petculescu, Anna L. Majury
The Use Of E. Coli Phylogrouping And Microbial Source Tracking (Non-Species Specific, Human-Specific, Bovine-Specific Bacteroidales Markers) To Elucidate Hydro(Geo)Logical Contamination Mechanisms In Southeastern Ontario, Canada, Madeleine Kelly, Paul Hynds, R. Stephen Brown, Kevin Mcdermott, Ioan Petculescu, Anna L. Majury
Articles
In Ontario, monitoring, maintenance, and treatment of private drinking systems (e.g. wells) are the responsibility of the well owner. Fecal contamination of drinking water threatens public health, particularly in rural communities which are often fully reliant on unregulated private groundwater as a primary drinking water source. Private well users face a higher risk of acute gastrointestinal illness compared to those served by municipally operated systems (Murphy et al., 2016). Accordingly, the current study sought to characterize the fecal indicator, E. coli, isolated from southeastern Ontario private groundwater wells, including phylogroups and host source. Results were examined in the context of …
A Rapid On-Site Loop-Mediated Isothermal Amplification Technology As An Early Warning System For The Detection Of Shiga Toxin-Producing Escherichia Coli In Water, Zina Alfahl, Sean Biggins, Owen Higgins, Alexandra Chueiri, Terry J. Smith, Dearbháile Morris, Jean O'Dwyer, Paul D. Hynds, Liam P. Burke, Louise O'Connor
A Rapid On-Site Loop-Mediated Isothermal Amplification Technology As An Early Warning System For The Detection Of Shiga Toxin-Producing Escherichia Coli In Water, Zina Alfahl, Sean Biggins, Owen Higgins, Alexandra Chueiri, Terry J. Smith, Dearbháile Morris, Jean O'Dwyer, Paul D. Hynds, Liam P. Burke, Louise O'Connor
Articles
Shiga toxin-producing Escherichia coli (STEC) is an important waterborne pathogen capable of causing serious gastrointestinal infections with potentially fatal complications, including haemolytic–uremic syndrome. All STEC serogroups harbour genes that encode at least one Shiga toxin (stx1 and/or stx2), which constitute the primary virulence factors of STEC. Loop-mediated isothermal amplification (LAMP) enables rapid real-time pathogen detection with a high degree of specificity and sensitivity. The aim of this study was to develop and validate an on-site portable diagnostics workstation employing LAMP technology to permit rapid real-time STEC detection in environmental water samples. Water samples (n=28) were collected from groundwater wells (n=13), …
Dynamic Life Cycle Assessment Of Commercial And Household Food Waste: A Critical Global Review Of Emerging Techniques, Majid Bahramian, Paul Dylan Hynds, Anushree Priyadarshini
Dynamic Life Cycle Assessment Of Commercial And Household Food Waste: A Critical Global Review Of Emerging Techniques, Majid Bahramian, Paul Dylan Hynds, Anushree Priyadarshini
Articles
DLCA has been applied to several food waste streams, however, to date no critical assessment of its strengths, weaknesses, opportunities, and threats (SWOT) is available in the scientific literature. Accordingly, the present review aims to provide a comprehensive overview of the available literature on DLCA and its application to Household and Commercial Food Waste (HCFW) by providing critical assessment and perspectives for future research. The Population, Intervention, Comparison, and Outcome (PICO) framework for literature review was employed, with just 12 relevant studies identified between 1999 and 2022, highlighting a dearth of research on DLCA of food waste and the need …
Evaluating The Health Implications Of Kombucha Fermented With Gardenia Jasminoides Teas: A Comprehensive Analysis Of Antioxidant, Antimicrobial, And Cytotoxic Properties, Gayathree Thenuwara, Xu Cui, Zhen Yao, Bilal Javed, Azza Silotry Naik, Furong Tian
Evaluating The Health Implications Of Kombucha Fermented With Gardenia Jasminoides Teas: A Comprehensive Analysis Of Antioxidant, Antimicrobial, And Cytotoxic Properties, Gayathree Thenuwara, Xu Cui, Zhen Yao, Bilal Javed, Azza Silotry Naik, Furong Tian
Articles
No abstract provided.
In Situ Tuning And Investigating The Growth Process Of Size Controllable Gold Nanoparticles And Statistical Size Prediction Analysis, Vinayak Sharma, Bilal Javed, Giovani Estrada, Hugh J. Byrne, Furong Tian
In Situ Tuning And Investigating The Growth Process Of Size Controllable Gold Nanoparticles And Statistical Size Prediction Analysis, Vinayak Sharma, Bilal Javed, Giovani Estrada, Hugh J. Byrne, Furong Tian
Articles
A critical understanding of the formation and growth process of gold nanoparticles (GNPs) is crucial, in order to synthesize monodisperse gold nanocrystals of controllable size and shape in a predictable way. GNPs of different shapes and sizes can be produced by altering different physicochemical reaction conditions, such as pH, temperature, and the ratio of reactants. The significant variations in the morphological features of GNPs can be monitored in situ in a time-dependent manner by using UV–visible spectroscopy. In this study, we have synthesized seedless GNPs by reduction of HAuCl4 by using various molar ratios of HEPES and Na2HPO4. The shape …
Mycotoxin Detection Through Colorimetric Immunoprobing With Gold Nanoparticle Antibody Conjugates, Vinayak Sharma, Bilal Javed, Hugh J. Byrne, Furong Tian
Mycotoxin Detection Through Colorimetric Immunoprobing With Gold Nanoparticle Antibody Conjugates, Vinayak Sharma, Bilal Javed, Hugh J. Byrne, Furong Tian
Articles
Driven by their exceptional optical characteristics, robust chemical stability, and facile bioconjugation, gold nanoparticles (AuNPs) have emerged as a preferred material for detection and biosensing applications in scientific research. This study involves the development of a simple, rapid, and cost-effective colorimetric immuno-sensing probe to detect aflatoxin B1 and zearalenone using AuNP antibody (AuNP-mAb) conjugates. Anti-toxin antibodies were attached to the AuNPs by using the physical adsorption method. The colorimetric immunosensor developed operates on the principle that the optical properties of the AuNP are very sensitive to aggregation, which can be induced by a critical high salt concentration. Although the presence …
Sex- And Gender-Specific Considerations In Mycotoxin Screening: Assessing Differential Exposure, Health Impacts, And Mitigation Strategies, Gayathree Thenuwara, Bilal Javed, Singh Baljit, Hugh J. Byrne, Furong Tian
Sex- And Gender-Specific Considerations In Mycotoxin Screening: Assessing Differential Exposure, Health Impacts, And Mitigation Strategies, Gayathree Thenuwara, Bilal Javed, Singh Baljit, Hugh J. Byrne, Furong Tian
Articles
Mycotoxins, toxic secondary metabolites produced by fungi, present significant health risks through contaminated food and feed. Despite broad documentation of their general impacts, emerging research highlights the requirement of addressing both sex- and gender-specific differences in the risk of exposure, susceptibility, and health outcomes in mycotoxin screening and mitigation strategies. Distinct biological (sex-based) and sociocultural (gender-based) factors can influence the risk of mycotoxin exposure and subsequent health impacts; women may for example exhibit specific exposures to certain mycotoxins due to physiological and hormonal differences, with increased risks during critical life stages such as pregnancy and lactation. Conversely, men may demonstrate …
Biosensor-Enhanced Organ-On-A-Chip Models For Investigating Glioblastoma Tumor Microenvironment Dynamics, Gayathree Thenuwara, Bilal Javed, Baljit Singh, Furong Tian
Biosensor-Enhanced Organ-On-A-Chip Models For Investigating Glioblastoma Tumor Microenvironment Dynamics, Gayathree Thenuwara, Bilal Javed, Baljit Singh, Furong Tian
Articles
Glioblastoma, an aggressive primary brain tumor, poses a significant challenge owing to its dynamic and intricate tumor microenvironment. This review investigates the innovative integration of biosensor-enhanced organ-on-a-chip (OOC) models as a novel strategy for an in-depth exploration of glioblastoma tumor microenvironment dynamics. In recent years, the transformative approach of incorporating biosensors into OOC platforms has enabled real-time monitoring and analysis of cellular behaviors within a controlled microenvironment. Conventional in vitro and in vivo models exhibit inherent limitations in accurately replicating the complex nature of glioblastoma progression. This review addresses the existing research gap by pioneering the integration of biosensor-enhanced OOC …
Characterization Of Spent Grain From Irish Whiskey Distilleries For Biorefinery Feedstock Potential To Produce High-Value Chemicals And Biopolymers, Rasaq S. Abolore, Dileswar Pradhan, Swarna Jaiswal, Amit K. Jaiswal
Characterization Of Spent Grain From Irish Whiskey Distilleries For Biorefinery Feedstock Potential To Produce High-Value Chemicals And Biopolymers, Rasaq S. Abolore, Dileswar Pradhan, Swarna Jaiswal, Amit K. Jaiswal
Articles
Distiller's spent grain (DSG) is a byproduct generated in large quantities during the mashing process, particularly in the production of alcoholic beverages such as whiskey. This study aimed to characterize DSG from nine different distilleries as a potential biorefinery feedstock for the synthesis of high-value bioproducts. Key components, including protein (12.38–26.32%), cellulose (11.75–32.75%), hemicellulose (6.97–19.47%), lignin (8.44–15.71%), and total phenolics (1.42 to 3.97 mg GAE/g), were analyzed to evaluate their variability and suitability for industrial applications. The results reveal that DSG composition varies significantly across distilleries due to differences in processing techniques, even though the starting grain composition had minimal …
A Comprehensive Review Of Food Safety Culture In The Food Industry: Leadership, Organizational Commitment, And Multicultural Dynamics, Ashwini Sadashiv Pai, Swarna Jaiswal, Amit K. Jaiswal
A Comprehensive Review Of Food Safety Culture In The Food Industry: Leadership, Organizational Commitment, And Multicultural Dynamics, Ashwini Sadashiv Pai, Swarna Jaiswal, Amit K. Jaiswal
Articles
Food safety culture (FSC) has transitioned from a narrow compliance-based concept to a comprehensive organisational value that is essential for ensuring food safety. This review explores the pivotal roles of leadership, organisational commitment, and cultural diversity in shaping an effective FSC. It highlights how leadership style, particularly transformational leadership, can enhance employee engagement and foster a proactive safety culture. Additionally, the impact of national and organisational cultures on FSC is analysed, emphasising the challenges posed by a multicultural workforce in standardising food safety practices. This article also provides a comparative analysis of FSC across various sectors, such as meat and …
Green And Sustainable Pretreatment Methods For Cellulose Extraction From Lignocellulosic Biomass And Its Applications: A Review, Rasaq S. Abolore, Swarna Jaiswal, Amit K. Jaiswal
Green And Sustainable Pretreatment Methods For Cellulose Extraction From Lignocellulosic Biomass And Its Applications: A Review, Rasaq S. Abolore, Swarna Jaiswal, Amit K. Jaiswal
Articles
Lignocellulose biomass (LCB) is a plant biomass mainly composed of cellulose, hemicellulose, and lignin. Cellulose is the most abundant biodegradable polymer on Earth and is very useful for various applications. However, the complex structure of lignocellulosic biomass, in which cellulose is tightly bound to hemicellulose and lignin, poses significant challenges in the isolation of cellulose from LCB components. This necessitates efficient pretreatment techniques to enable cellulose separation. Conventional pretreatment methods are not sustainable because they involve the use of harsh chemicals, elevated temperatures, high energy consumption, low productivity, and the formation of fermentation inhibitors which can increase the cost of …
Augmenting K-Means Clustering With Qualitative Data To Discover The Engagement Patterns Of Older Adults With Multimorbidity When Using Digital Health Technologies: Proof-Of-Concept Trial, Yiyang Sheng, Raymond Bond, Rajesh Jaiswal, John Dinsmore, Julie Doyle
Augmenting K-Means Clustering With Qualitative Data To Discover The Engagement Patterns Of Older Adults With Multimorbidity When Using Digital Health Technologies: Proof-Of-Concept Trial, Yiyang Sheng, Raymond Bond, Rajesh Jaiswal, John Dinsmore, Julie Doyle
Articles
Background: Multiple chronic conditions (multimorbidity) are becoming more prevalent among aging populations. Digital health technologies have the potential to assist in the self-management of multimorbidity, improving the awareness and monitoring of health and well-being, supporting a better understanding of the disease, and encouraging behavior change. Objective: The aim of this study was to analyze how 60 older adults (mean age 74, SD 6.4; range 65-92 years) with multimorbidity engaged with digital symptom and well-being monitoring when using a digital health platform over a period of approximately 12 months. Methods: Principal component analysis and clustering analysis were used to group participants …
Optical Response Of Pdms Surface Diffraction Gratings Under Exposure To Volatile Organic Compounds, Aleksandra Hernik, Faolan Radford Mcgovern, Izabela Naydenova
Optical Response Of Pdms Surface Diffraction Gratings Under Exposure To Volatile Organic Compounds, Aleksandra Hernik, Faolan Radford Mcgovern, Izabela Naydenova
Articles
Monitoring volatile organic compounds (VOCs) in indoor air is significantly gaining importance due to their adverse effects on human health. Among the diverse detection methods is optical sensing, which employs materials sensitive to the presence of gases in the environment. In this work, we investigate polydimethylsiloxane (PDMS), one of the materials utilized for gas sensing, in a novel transducer: a surface relief diffraction grating. Upon adsorption of the volatile analyte, the PDMS grating swells, and its refractive index changes; both effects lead to increased diffraction efficiency in the first diffraction order. Hence, the possibility of VOC detection emerges from the …
Esg, The Sec Climate Rule, And The Limits Of Securities Regulation, Kenneth M. Rosen
Esg, The Sec Climate Rule, And The Limits Of Securities Regulation, Kenneth M. Rosen
Articles
No abstract provided.
Tax Incentives For Investment Crowdfunding: A Comparative Analysis, Mirit Eyal-Cohen
Tax Incentives For Investment Crowdfunding: A Comparative Analysis, Mirit Eyal-Cohen
Articles
No abstract provided.
The Detailed Analysis Of The Microbiome And Resistome Of Artisanal Blue-Veined Cheeses Provides Evidence On Sources And Patterns Of Succession Linked With Quality And Safety Traits, Elena Alexandra Alexa, Jose Francisco Cobo-Diaz, Erica Renes, Tom F. O'Callaghan, Kieran Kilcawley, David Mannion, Iwona Skibinska, Lorena Ruiz, Abelardo Margolles, Paula Fernandez-Gomez, Adrian Alvarez-Molina, Paula Puente-Gomez, Fiona Crispie, Mercedes Lopez, Miguel Prieto Maradona, Paul D. Cotter, Avelino Alvarez-Ordonez
The Detailed Analysis Of The Microbiome And Resistome Of Artisanal Blue-Veined Cheeses Provides Evidence On Sources And Patterns Of Succession Linked With Quality And Safety Traits, Elena Alexandra Alexa, Jose Francisco Cobo-Diaz, Erica Renes, Tom F. O'Callaghan, Kieran Kilcawley, David Mannion, Iwona Skibinska, Lorena Ruiz, Abelardo Margolles, Paula Fernandez-Gomez, Adrian Alvarez-Molina, Paula Puente-Gomez, Fiona Crispie, Mercedes Lopez, Miguel Prieto Maradona, Paul D. Cotter, Avelino Alvarez-Ordonez
Articles
BackgroundArtisanal cheeses usually contain a highly diverse microbial community which can significantly impact their quality and safety. Here, we describe a detailed longitudinal study assessing the impact of ripening in three natural caves on the microbiome and resistome succession across three different producers of Cabrales blue-veined cheese.ResultsBoth the producer and cave in which cheeses were ripened significantly influenced the cheese microbiome. Lactococcus and the former Lactobacillus genus, among other taxa, showed high abundance in cheeses at initial stages of ripening, either coming from the raw material, starter culture used, and/or the environment of processing plants. Along cheese ripening in caves, …
Analysis Of Physicochemical And Phytonutrients Properties Of Bastard Oleaster Fruits And Its Mass Prediction Using Artificial Neural Network Model, Raju Sasikumar, Kambhampati Vivek, Govindasamy Kadirvel, Amit K. Jaiswal
Analysis Of Physicochemical And Phytonutrients Properties Of Bastard Oleaster Fruits And Its Mass Prediction Using Artificial Neural Network Model, Raju Sasikumar, Kambhampati Vivek, Govindasamy Kadirvel, Amit K. Jaiswal
Articles
Bastard oleaster (Elaeagnus latifolia) is highly nutritious, rich in various vitamins (A, C, E) and minerals (P, K, Ca, Mg, Na), yet remains underutilized despite its immense potential. This study focused on the physicochemical and thermal properties of the fruit, and also aimed at accurately predicting its mass. A four-layered back-propagation artificial neural network (ANN) algorithm demonstrated excellent predictive capabilities, achieving the highest R2 values in training (0.9789) and testing (0.9901), with minimal error using the Log/Tan/Tan activation function trained with Trainlm. Additionally, the research assessed antinutritional properties and employed UPLC to identify and quantify phenolic compounds in E. latifolia. …
Hydrothermal Liquefaction Of Wet Microalgal Biomass For Biofuels And Platform Chemicals: Advances And Future Prospects, Charu Deepika, Mrinal, Cheryl Bernice Pohrmen, Km Smriti Jaiswal, B. Sangmesh, Krishna Kumar Jaiswal, Arun Prasath Ramasamy, Amit K. Jaiswal
Hydrothermal Liquefaction Of Wet Microalgal Biomass For Biofuels And Platform Chemicals: Advances And Future Prospects, Charu Deepika, Mrinal, Cheryl Bernice Pohrmen, Km Smriti Jaiswal, B. Sangmesh, Krishna Kumar Jaiswal, Arun Prasath Ramasamy, Amit K. Jaiswal
Articles
Recent advances in hydrothermal liquefaction (HTL) have established this biomass conversion technology as a potent tool for the effective valorization and energy densification of varied feedstocks, ranging from lignocelluloses to microalgae and organic wastes. Emphasizing its application across biomass types, this exploration delves into the evolving landscape of HTL. Microalgae, recognized as a promising feedstock, offer a rich source of biomolecules, including lipids, carbohydrates, and proteins, making them particularly attractive for biofuel production. The comprehensive review explores the biofuel products and platform chemicals obtained through HTL of microalgae, delving into biodiesel production, bio-oil composition, characteristics, and to produce high-valued by-products. …
Agro-Food Waste Valorization For Sustainable Bio-Based Packaging, Luana De S.C. Carnaval, Amit K. Jaiswal, Swarna Jaiswal
Agro-Food Waste Valorization For Sustainable Bio-Based Packaging, Luana De S.C. Carnaval, Amit K. Jaiswal, Swarna Jaiswal
Articles
In recent years, the increase in the generation of agro-food processing waste, coupled with uncontrolled disposal and inefficient recovery methods, has raised concerns among society, industries, and the research community. This issue is compounded by the accumulation of conventional synthetic packaging. Owing to their significant environmental and economic impacts, the development of sustainable, biocompatible, and biodegradable materials has become an urgent target. In this context, research efforts have been directed toward developing new packaging materials based on renewable sources, such as agro-food waste, contributing to the circular economy concept. However, despite significant advances, novel agro-food-waste-based packaging solutions still largely remain …
The Potential Of Edible Insects As A Safe, Palatable, And Sustainable Food Source In The European Union, Ann D. Conway, Swarna Jaiswal, Amit K. Jaiswal
The Potential Of Edible Insects As A Safe, Palatable, And Sustainable Food Source In The European Union, Ann D. Conway, Swarna Jaiswal, Amit K. Jaiswal
Articles
Entomophagy describes the practice of eating insects. Insects are considered extremely nutritious in many countries worldwide. However, there is a lethargic uptake of this practice in Europe where consuming insects and insect-based foodstuffs is often regarded with disgust. Such perceptions and concerns are often due to a lack of exposure to and availability of food-grade insects as a food source and are often driven by neophobia and cultural norms. In recent years, due to accelerating climate change, an urgency to develop alternate safe and sustainable food-sources has emerged. There are currently over 2000 species of insects approved by the World …
Microbial And Enzymatic Biodegradation Of Plastic Waste For A Circular Economy, Muhammad Aitzaz Akram, Rangasamy Savitha, Gemma K. Kinsella, Kieran Nolan, Barry J. Ryan, Gary T. Henehan
Microbial And Enzymatic Biodegradation Of Plastic Waste For A Circular Economy, Muhammad Aitzaz Akram, Rangasamy Savitha, Gemma K. Kinsella, Kieran Nolan, Barry J. Ryan, Gary T. Henehan
Articles
Plastics play a crucial role in modern life, but their accumulation poses a serious threat to both the environment and human health. Due to their effects on the terrestrial and aquatic environment, it is essential to develop sustainable approaches to dispose of waste plastics. Traditional methods of plastic disposal, such as burning and landfilling, are problematic since they produce hazardous byproducts. Biodegradation is a potentially effective, eco-friendly approach which uses microbial consortia or isolated enzymes to break down plastic waste. Enzymes interact with plastic surfaces and hydrolyse the large polymer chains into smaller units. These byproducts can then be utilised …
Chemical Modification Of Bacterial Exopolysaccharides: Antioxidant Properties And Health Potentials, Irshad Ahmad Shah, Digambar Kavitake, Swati Tiwari, Palanisamy Bruntha Devi, G. Bhanuprakash Reddy, Krishna Kumar Jaiswal, Amit K. Jaiswal, Prathapkumar Halady Shetty
Chemical Modification Of Bacterial Exopolysaccharides: Antioxidant Properties And Health Potentials, Irshad Ahmad Shah, Digambar Kavitake, Swati Tiwari, Palanisamy Bruntha Devi, G. Bhanuprakash Reddy, Krishna Kumar Jaiswal, Amit K. Jaiswal, Prathapkumar Halady Shetty
Articles
In recent years, there has been a burgeoning interest in the utilization of microbial exopolysaccharides (EPS) because of the added advantage of their renewable, biocompatible, and biodegradable nature in addition to intended applications. The endowed properties of bacterial EPS make them valuable candidates for a wide array of industrial applications. Modification of native EPS is known to enhance various physico-chemical and functional properties. Various modifications such as physical, chemical, biological, and enzymatic modifications were practiced improving the bioactivity of EPS. This paper comprehensively aims to review the most recent chemical modification techniques employed to modify the physico-chemical and functional changes …
The American Antimonopoly Tradition: Origins, Contradictions, Transformations, Daniel A. Crane
The American Antimonopoly Tradition: Origins, Contradictions, Transformations, Daniel A. Crane
Articles
Proponents of antitrust reform argue for the rediscovery of an American antimonopoly tradition that predated the Sherman Act by centuries and suggests the reimagination of a more robust contemporary policy against concentrated economic power. But historically there have been a number of distinct and often contradictory strands of American antimonopoly. The American colanists inherited a weak, recent, and largely invented antimonopoly common law tradition focused on exclusive grants of privilege from the crown. In the nineteenth century, antimonopoly became a generative and ubiquitous concept in state legislatures and courts, but one with multiple, inconsistent meanings that evolved in the decades …
Consent Searches As Police Violence, David B. Owens
Consent Searches As Police Violence, David B. Owens
Articles
Henderson and Krishnamurthi’s new paper—A Wolf in Sheep’s Attire: How Consent Enfeebles Our Fourth Amendment (hereinafter Sheep’s Attire)— powerfully advocates for reform to the consent doctrine. The paper is thoughtful, well-intentioned, and useful for challenging core assumptions about the law to help us evaluate how it should work. The piece is also fun to read as the authors breathe real-world insight into old doctrine. In the end, though the article flirts with a categorical rule about consent searches, and while the authors “think it categorically unreasonable for police to ask individuals to forgo their rights” in the context …
Founder Worship, Effective Altruism, And Corporate Governance, Jennifer S. Fan, Xuan-Thao Nguyen
Founder Worship, Effective Altruism, And Corporate Governance, Jennifer S. Fan, Xuan-Thao Nguyen
Articles
Founders are the heart of any startup. Oftentimes, they are given considerable latitude in managing a company, particularly if they are hailed as a visionary founder in a pathbreaking new industry. Additionally, it is assumed that underpinning their actions is the desire to do good. Unfortunately, sometimes this leads to what we term founder worship where the promise of the founder and the innovation may lead to perverse outcomes because too much control is ceded to the founder and there is a lack (or sometimes complete absence of) corporate governance. When unlimited control is coupled with "do gooderism," which in …
Synthesis Of Cationic Liposome Nanoparticles Using A Thin Film Dispersed Hydration And Extrusion Method, Alessandro Cazzolla, Julie Rose Mae Mondala, Janith Wanigasekara, Joanna Carroll, Noah Daly, Brijesh Tiwari, Alan Casey, James F. Curtin
Synthesis Of Cationic Liposome Nanoparticles Using A Thin Film Dispersed Hydration And Extrusion Method, Alessandro Cazzolla, Julie Rose Mae Mondala, Janith Wanigasekara, Joanna Carroll, Noah Daly, Brijesh Tiwari, Alan Casey, James F. Curtin
Articles
Liposome nanoparticles can carry a wide range of therapeutic molecules including small molecules and nucleic acid-based therapeutics. Potential benefits include translocation across physiological barriers, reduced systemic toxicity, and enhanced pharmacokinetic parameters such as absorption, distribution, selective release and optimal elimination kinetics. Liposome nanoparticles can be generated with a wide range of natural and synthetic lipid-based molecules that confer desirable properties depending on the desired therapeutic application Nel et al (2023), Large (2021), Elkhoury (2020). This protocol article seeks to detail the procedures involved in the production of cationic liposomes using thin-film dispersed hydration method with an estimated uniform size of …
Synergistic Cytotoxicity Effect Of Ultrasound And Plasma Microbubble In Glioblastoma 3d Tumor Sphere Model, Janith Wanigasekara, Patrick J. Cullen, Brijesh Tiwari, James F. Curtin
Synergistic Cytotoxicity Effect Of Ultrasound And Plasma Microbubble In Glioblastoma 3d Tumor Sphere Model, Janith Wanigasekara, Patrick J. Cullen, Brijesh Tiwari, James F. Curtin
Articles
The combined application of ultrasound (US) and plasma microbubble (PMB) is a promising technology against glioblastoma (GBM). Here, we determined the effects of US and PMB (alone and combined) on U-251 MG GBM and A431 epidermoid carcinoma spheroids under different conditions. The synergistic treatment of US- and PMB-induced tumor sphere cell death in a time-, dose-, treatment frequency-, and reactive oxygen species dependent manner, while multiple treatments augmented this effect. Synergistic treatments significantly reduced three-dimensional GBM spheroid regrowth and cell proliferation while inducing cytotoxicity, spheroid shrinkage, and damage to the tumor microenvironment. PMB-induced cytotoxicity throughout the tumor sphere, likely via …