Digital Commons Network^™

A Comity Of Errors: The Rise, Fall, And Return Of International Comity In Transnational Discovery, Diego Zambrano

Articles

No abstract provided.

Antibody Regeneration On Degenerate Si Electrodes For Calibration And Reuse Of Impedance Biosensors, Ian Suni

Articles

Mild denaturing agents were studied for antibody regeneration atop degenerate (highly doped) Si and Au electrodes using comparable 11-carbon chain linker reagents onto which the mouse monoclonal antibody to peanut protein Ara h 1 is covalently immobilized. Of the reagents studied, only 200 mM KSCN is effective for antibody regeneration and detection of Ara h 1 atop Au electrodes, allowing 15 days of sensor usage after daily antibody unfolding and refolding, while 200 mM KSCN +10 mM HF is effective atop degenerate Si electrodes, allowing 30 days of sensor usage. The addition of HF is required for antibody regeneration atop …

Cyclicity Versus Movement: English Nominalization And Syntactic Approaches To Morpho-Phonological Regularity, Jeffrey Punske

Articles

In this paper, I show that Embick’s (2010) cyclic head approach to regular morphology alone cannot account for the freely available variations in the realization of nominalizers in English nominalizations involving overt verbalizers. Instead, I offer an account of the regularity effects using the technology of Local Dislocation (Embick and Noyer 2001, Embick and Marantz 2008, Embick 2007a, 2007b). Using this analysis, I derive both the variable nominalization patterns and the restrictions on particles and results in derived nominals from Sichel (2010). By treating regularity as the by-product of extant morphosyntatic operations, we can better explain the distribution of regular …

Clca2 Interactor Eva1 Is Required For Mammary Epithelial Cell Differentiation., Grace Ramena, Yufang Yin, Yang Yu, Vijay Walia, Randolph C Elble

Articles

CLCA2 is a p53-, p63-inducible transmembrane protein that is frequently downregulated in breast cancer. It is induced during differentiation of human mammary epithelial cells, and its knockdown causes epithelial-to-mesenchymal transition (EMT). To determine how CLCA2 promotes epithelial differentiation, we searched for interactors using membrane dihybrid screening. We discovered a strong interaction with the cell junctional protein EVA1 (Epithelial V-like Antigen 1) and confirmed it by co-immunoprecipitation. Like CLCA2, EVA1 is a type I transmembrane protein that is regulated by p53 and p63. It is thought to mediate homophilic cell-cell adhesion in diverse epithelial tissues. We found that EVA1 is frequently …

Sec Investigations And Securities Class Actions: An Empirical Comparison, Stephen J. Choi, Adam C. Pritchard

Articles

Using actions with both an SEC investigation and a class action as our baseline, we compare the targeting of SEC-only investigations with class-action-only lawsuits. Looking at measures of information asymmetry, we find that investors in the market perceive greater information asymmetry following the public announcement of the underlying violation for class-action-only lawsuits compared with SEC-only investigations. Turning to sanctions, we find that the incidence of top officer resignation is greater for class-action-only lawsuits relative to SEC-only investigations. Our findings are consistent with the private enforcement targeting disclosure violations at least as precisely as (if not more so than) SEC enforcement.

Trade Credit And Taxes, Mihir A. Desai, C. Fritz Foley, James R. Hines Jr.

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This paper analyzes the extent to which tax differences affect the use of trade credit. U.S.-owned affiliates in low-tax countries use trade credit to lend, whereas those in high-tax countries use trade credit to borrow: 10% lower local tax rates are associated with net trade credit positions that are 1.4% higher as a fraction of sales. The use of trade credit to get capital out of low-tax, low-return environments is also illustrated by the temporary repatriation tax holiday in 2005, which was used most intensively by affiliates with positive net trade credit positions.

Reconceptualizing The Eighth Amendment: Slaves, Prisoners, And Cruel And Unusual Punishment, Alexander A. Reinert

Articles

The meaning of the Eighth Amendment’s Cruel and Unusual Punishment Clause has long been hotly contested. For scholars and jurists who look to original meaning or intent, there is little direct contemporaneous evidence on which to rest any conclusion. For those who adopt a dynamic interpretive framework, the Supreme Court’s “evolving standards of decency” paradigm has surface appeal, but deep conflicts have arisen in application. This Article offers a contextual account of the Eighth Amendment’s meaning that addresses both of these interpretive frames by situating the Amendment in eighteenth and nineteenth-century legal standards governing relationships of subordination.

In particular, I …

Recent Advances In Optical Diagnosis Of Oral Cancers: Review And Future Perspectives, Ola Ibrahim, Hugh Byrne, Fiona Lyng, Surya Singh, Jopi Mikkonen, Arto Koistinen, Arja Kullaa

Articles

Optical diagnosis techniques offer several advantages over traditional approaches, including objectivity, speed and cost, and these label-free, non-invasive methods have the potential to change the future work-flow of cancer management. The oral cavity is particularly accessible and thus such methods may serve as alternate/adjunct tools to traditional methods. Recently, in vivo human clinical studies have been initiated with a view to clinical translation of such technologies. A comprehensive review of optical methods in oral cancer diagnosis is presented. Following an introduction to the epidemiology and aetiological factors associated with oral cancers currently employed diagnostic methods and their limitations are presented. …

Manufacturing Barriers To Biologics Competition And Innovation, W. Nicholson Price Ii., Arti K. Rai

Articles

As finding breakthrough small-molecule drugs becomes more difficult, drug companies are increasingly turning to "large molecule" biologics. Although biologics represent many of the most promising new therapies for previously intractable diseases, they are extremely expensive. Moreover, the pathway for generic-type competition set up by Congress in 2010 is unlikely to yield significant cost savings. This Article provides a fresh diagnosis of and prescription for this major public policy problem. It argues that the key cause is pervasive trade secrecy in the complex area of biologics manufacturing. Under the current regime, this trade secrecy, combined with certain features of Food and …

A Liberal Dilemma: Respecting Autonomy While Also Protecting Inchoate Children From Prenatal Substance Abuse., Andrew J. Weisberg, Frank E. Vandervort

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Substance abuse is a significant social problem in America. It is estimated that some eighteen million Americans have an alcohol abuse problem and that almost five million have a drug abuse problem. According to the National Institute on Drug Abuse, substance abuse costs some $700 billion per year Substance abuse is a major contributor to child maltreatment. It is estimated that between one- and two-thirds of cases in which children enter foster care are linked to parental substance abuse. Unfortunately, this may be an underestimate as recent research suggests that many cases, particularly cases in which children have been exposed …

Economic Crisis And The Integration Of Law And Finance: The Impact Of Volatility Spikes, Edward G. Fox, Merritt B. Fox, Ronald J. Gilson

Articles

The 2008 financial crisis raised puzzles important for understanding how the capital market prices common stocks and in turn, for the intersection between law and finance. During the crisis, there was a dramatic five-fold spike, across all industries, in “idiosyncratic risk”—the volatility of individual-firm share prices after adjustment for movements in the market as a whole.

This phenomenon is not limited to the most recent financial crisis. This Article uses an empirical review to show that a dramatic spike in idiosyncratic risk has occurred with every major downturn from the 1920s through the recent financial crisis. It canvasses three possible …

Editorial: Glial Cells: Managers Of Neuro-Immunity, Carlos Barcia, Gilles Guillemin, James Curtin, Jeffrey Zirger

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No abstract provided.

Development Of Socially Responsive Competency Frameworks For Ophthalmic Technicians And Optometrists In Mozambique, Kajal Shah, Kevin Naidoo, James Loughman

Articles

There is an extreme paucity of eye care personnel and training facilities in developing countries. This study was designed to develop a comprehensive framework of competency standards for ophthalmic technicians and optometrists, in Mozambique. This could then inform the evolution of socially responsive curricula for both cadres. Methods A modified Delphi technique was used with a ten member expert panel consisting of optometrists, ophthalmic technicians and ophthalmologists, all with experience of working in a developing country context. The competencies were derived from literature, primary research data and observations from a competency development workshop. The first round involved scoring the relevance …

Mobilaudio – A Multimodal Content Delivery Platform For Geo-Services, James Carswell, Keith Gardiner, Charlie Cullen

Articles

Delivering high-quality context-relevant information in a timely manner is a priority for location-based services (LBS) where applications require an immediate response based on spatial interaction. Previous work in this area typically focused on ever more accurately determining this interaction and informing the user in the customary graphical way using the visual modality. This paper describes the research area of multimodal LBS and focuses on audio as the key delivery mechanism. This new research extends familiar graphical information delivery by introducing a geoservices platform for delivering multimodal content and navigation services. It incorporates a novel auditory user interface (AUI) that enables …

Solving The Moro Problem: Legalizing The Bangsamoro Peace Process, Gene Carolan

Articles

The purpose of this paper is to highlight the structural features that are proving central to the stability of the 2014 Comprehensive Agreement on the Bangsamoro between the Government of the Philippines and the Moro Islamic Liberation Front, and those features that were detrimental to its predecessors.

This paper finds that a more highly legalized approach to peace-making has resulted in greater agreement stability in the Philippines. More precise in detail and inclusive in scope, the legal nature of the 2014 Comprehensive Agreement has made it more responsive to the root causes of the conflict, and resilient to incidents that …

Spectral Pre And Post Processing For Infrared And Raman Spectroscopy Of Biological Tissues And Cells, Hugh Byrne, Peter Knief, Mark Keating, Franck Bonnier

Articles

Vibrational Spectroscopy, both infrared absorption and Raman spectroscopy, have attracted increasing attention for biomedical applications, from in vivo and ex vivo disease diagnostics and screening, to in vitro screening of therapeutics. There remain, however, many challenges related to the accuracy of analysis of physically and chemically inhomogeneous samples, across heterogeneous sample sets. Data preprocessing is required to deal with variations in instrumental responses and intrinsic spectral backgrounds and distortions in order to extract reliable spectral data. Data postprocessing is required to extract the most reliable information from the sample sets, based on often very subtle changes in spectra associated with …

Amorphous Silicon Solar Vivaldi Antenna, Oisin O'Conchubhair, Kansheng Yang, Patrick Mcevoy, Max Ammann

Articles

An ultra-wideband solar Vivaldi antenna is proposed. Cut from amorphous silicon cells, it maintains a peak power at 4.25 V which overcomes a need for lossy power management components. The wireless communications device can yield solar energy or function as a rectenna for dual-source energy harvesting. The solar Vivaldi performs with 0.5 - 2.8 dBi gain from 0.95 - 2.45 GHz and in rectenna mode, it covers three bands for wireless energy scavenging.

Pesticide Degradation In Water Using Atmospheric Air Coldplasma, Chaitanya Sarangapani, Paula Bourke, N. Misra, Vladimir Milosavljevic, Finbarr O'Regan, Patrick J. Cullen

Articles

A high voltage dielectric barrier discharge plasma reactor using atmospheric air as the inducer gas was studied for the degradation of pesticides (dichlorvos, malathion, endosulfan) in water. The degradation kinetics of the pesticides were studied using GC–MS as a function of plasma control parameters. Electrical characterisation of the plasma revealed that the plasma discharge consisted of filamentary streamers. Excited nitrogen, reactive oxygen species and OH radicals generated in the dielectric barrier discharge (DBD) plasma reactor were identified using optical emission spectroscopy. Ozone, used as an indicator for metastable oxygen species, was quantified within the reactor at concentrations of 1600, 2200, …

Monitoring Hiv And Aids Related Policy Reforms: A Road Map To Strengthen Policy Monitoring And Implementation In Pepfar Partner Countries, Jeffrey Lane, Andre Verani, Mai Hijazi, Erin Hurley, Amy Hagopian, Nicole Judice, Ron Macinnis, Sallie Sanford, Sarah Zelek, Aaron Katz

Articles

Achieving an AIDS-free generation will require the adoption and implementation of critical health policy reforms. However, countries with high HIV burden often have low policy development, advocacy, and monitoring capacity. This lack of capacity may be a significant barrier to achieving the AIDS-free generation goals. This manuscript describes the increased focus on policy development and implementation by the United States President’s Emergency Plan for AIDS Relief (PEPFAR). It evaluates the curriculum and learning modalities used for two regional policy capacity building workshops organized around the PEPFAR Partnership Framework agreements and the Road Map for Monitoring and Implementing Policy Reforms. …

The Acceptability And Visual Impact Of 0.01% Atropine In A Caucasian Population, James Loughman, Daniel Ian Flitcroft

Articles

Myopia is a condition of enormous public health concern, affecting up to 2.5 billion people worldwide. The most effective treatment to prevent myopia progression is atropine but at the cost of accommodative paresis and mydriasis, necessitating the use of bifocal glasses. Low-dose atropine (0.01%) has been found to be almost as effective with significantly reduced side effects. Since there are well-recognised differences in the effect of atropine between heavily pigmented Asian eyes and Caucasian eyes, this study aimed to determine the acceptability and tolerability of 0.01% atropine (by measuring visual performance and quality of life) as a treatment for myopia …

Homeostatic Signaling By Cell-Cell Junctions And Its Dysregulation During Cancer Progression., Yang Yu, Randolph C Elble

Articles

The transition of sessile epithelial cells to a migratory, mesenchymal phenotype is essential for metazoan development and tissue repair, but this program is exploited by tumor cells in order to escape the confines of the primary organ site, evade immunosurveillance, and resist chemo-radiation. In addition, epithelial-to-mesenchymal transition (EMT) confers stem-like properties that increase efficiency of colonization of distant organs. This review evaluates the role of cell-cell junctions in suppressing EMT and maintaining a quiescent epithelium. We discuss the conflicting data on junctional signaling in cancer and recent developments that resolve some of these conflicts. We focus on evidence from breast …

Ultrasound Assisted Extraction Of Phenolic Compounds From Peaches And Pumpkins, Ammar Altemimi, Dennis G. Watson, Ruplal Choudhary, Malika R. Dasari, David A. Lightfoot

Articles

The ultrasound-assisted extraction (UAE) method was used to optimize the extraction of phenolic compounds from pumpkins and peaches. The response surface methodology (RSM) was used to study the effects of three independent variables each with three treatments. They included extraction temperatures (30, 40 and 50 ̊C), ultrasonic power levels (30, 50 and 70 %) and extraction times (10, 20 and 30 min). The optimal conditions for extractions of total phenolics from pumpkins were inferred to be a temperature of 41.45 ̊C, a power of 44.60 % and a time of 25.67 min. However, an extraction temperature of 40.99 ̊C, power …

Constructing Modular And Universal Single Molecule Tension Sensor Using Protein G To Study Mechano-Sensitive Receptors, Xuefeng Wang, Zainab Rahil, Isaac T. S. Li, Farhan Chowdhury, Deborah E. Leckband, Yann R. Chemla, Taekjip Ha

Articles

Recently a variety of molecular force sensors have been developed to study cellular forces acting through single mechano-sensitive receptors. A common strategy adopted is to attach ligand molecules on a surface through engineered molecular tethers which report cell-exerted tension on receptor-ligand bonds. This approach generally requires chemical conjugation of the ligand to the force reporting tether which can be time-consuming and labor-intensive. Moreover, ligand-tether conjugation can severely reduce the activity of protein ligands. To address this problem, we developed a Protein G (ProG)-based force sensor in which force-reporting tethers are conjugated to ProG instead of ligands. A recombinant ligand fused …

Beps - A Primer On Where It Came From And Where It’S Going, Jeffrey M. Kadet

Articles

Governments throughout the world have been losing many billions of dollars of tax revenues from “legal” tax avoidance conducted by many multinational groups (MNEs) through aggressive structuring of operations and transactions that often lack economic reality so as to earn profits that are subjected to zero or low-taxation. The success of this “legal” tax avoidance motivated the G-20 and the OECD to initiate the two-year Base Erosion and Profit Shifting (BEPS) project, which took place from 2013 to 2015.

This discussion of the BEPS project is intended to give the reader an understanding of the project’s origin, its objectives, and …

Reply To Five Critics Of Why Tolerate Religion?, Brian Leiter

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No abstract provided.

Acellular Reactivity Of Polymeric Dendrimer Nanoparticles As An Indicator Of Oxidative Stress In Vitro, Marcus Maher, Humza Khalid, Hugh Byrne

Articles

The need for rapid and cost effective pre-screening protocols of the toxicological response of the vast array of emerging nanoparticle types is apparent and the emerging consensus on the paradigm of oxidative stress by generation of intracellular reactive oxygen species as a primary source of the toxic response suggests the development of acellular assays to screen for nanoparticle surface reactivity. This study explores the potential of the monoamine oxidase A (MAO-A) enzyme based assay with polymeric dendrimers as cofactors and serotonin as substrate, which generates H₂O₂, quantified by the conversion of the Carboxy-H₂DCFDA dye …

Second Order Approximation For Heat Conduction: Dissipation Principle And Free Energies, Giovambattista Amendola, Mauro Fabrizio, John Murrough Golden, Barbara Lazzari

Articles

In the context of new models of heat conduction, the second-order approximation of Tzou’s theory, derived by Quintanilla and Racke, has been studied recently by two of the present authors, where it was proved equivalent to a fading memory material. The importance of determining free energy functionals for such materials, and indeed for any material with memory, is emphasized. Because the kernel does not satisfy certain convexity restrictions that allow us to obtain various traditional free energies for materials with fading memory, it is necessary to restrict the study to the minimum and related free energies, which do not require …

Non-Thermal Atmospheric Plasma Induces Ros-Independent Cell Death In U373mg Glioma Cells And Augments The Cytotoxicity Of Temozolomide, Gillian Conway, Alan Casey, Vladimir Milosavljevic, Yupeng Liu, Orla L. Howe, Patrick J. Cullen, James Curtin

Articles

Non-thermal atmospheric plasma (NTAP) is an ionised gas produced under high voltage that can generate short-lived chemically active species and induce a cytotoxic insult in cancer cells. Cell-specific resistance to NTAP-mediated cytotoxicity has been reported in the literature. The aim of this study was to determine whether resistance against NTAP could be overcome using the human glioma cell line U373MG.

Methods:

Non-thermal atmospheric plasma was generated using a Dielectric Barrier Device (DBD) system with a maximum voltage output of 120 kV at 50 Hz. The viability of U373MG GBM cells and HeLa cervical carcinoma cells was determined using morphology, flow …

Structural Dependence Of The In Vitro Cytotoxicity, Oxidative Stress And Uptake Mechanisms Of Poly(Propylene Imine) Dendritic Nanoparticles, Humza Khalid, Sourav Prasanna Mukherjee, Luke O'Neill, Hugh Byrne

Articles

The in vitro cytotoxic and intracellular oxidative stress responses to exposure to poly (propylene imine) (PPI) dendritic nanoparticles of increasing generation (number of repeated branching cycles) (G0-G4) were assessed in an immortal non-cancerous human keratinocyte cell-line (HaCaT). Confocal fluorescence microscopy with organelle staining was used to explore the uptake and intracellular trafficking mechanisms. A generation and dose dependent cytotoxic response was observed, increasing according to generation and therefore number of surface amino groups. A comparison of the cytotoxic response of G4 PPI and the related G4 Poly (amido amine) dendrimer indicates that the PPI with the same number of surface …

Charging On The Margin, Paul Crane

Articles

No abstract provided.