Digital Commons Network^™

Transitioning To Minimal Footwear: A Systematic Review Of Methods And Future Clinical Recommendations, Joe Warne, Allison H. Gruber

Articles

Recent interest in barefoot running has led to the development of minimalist running shoes that are popular in distance runners. A careful transition to these shoes has been suggested and examined in the literature. However, no guidelines based on systematic evidence have been presented.

A Six Stage Operational Framework For Individualising Injury Risk Management In Sport, Mark Roe, Shane Malone, Catherine Blake, Kieran Collins, Conor Gissane, Fionn Buttner, John C. Murphy, Eamonn Delahunt

Articles

Managing injury risk is important for maximising athlete availability and performance. Although athletes are inherently predisposed to musculoskeletal injuries by participating in sports, etiology models have illustrated how susceptibility is influenced by repeat interactions between the athlete (i.e. intrinsic factors) and environmental stimuli (i.e. extrinsic factors). Such models also reveal that the likelihood of an injury emerging across time is related to the interconnectedness of multiple factors cumulating in a pattern of either positive (i.e. increased fitness) or negative adaptation (i.e. injury).

Co-Colonisation With Aspergillus Fumigatus And Pseudomonas Aeruginosa Is Associated With Poorer Health In Cystic Fibrosis Patients: An Irish Registry Analysis, Emma Reece, Ricardo Segurado, Abaigeal Jackson, Siobhan Mcclean, Julie Renwick, Peter Greally

Articles

Pulmonary infection is the main cause of death in cystic fibrosis (CF). Aspergillus fumigatus (AF) and Pseudomonas aeruginosa (PA) are the most prevalent fungal and bacterial pathogens isolated from the CF airway, respectively. Our aim was to determine the effect of different colonisation profiles of AF and PA on the clinical status of patients with CF.

Macrophage Migration Inhibitory Factor Enhances Pseudomonas Aeruginosa Biofilm Formation, Potentially Contributing To Cystic Fibrosis Pathogenesis, Aisling Tynan, Leona Mawhinney, Michelle Armstrong, Ciaran O'Reilly, Sarah Kennedy

Articles

Macrophage migration inhibitory factor (MIF) is a key proinflammatory mediator that we have previously shown to be associated with an aggressive clinical phenotype in cystic fibrosis. It possesses unique tautomerase enzymatic activity. However, to date, no human-derived substrate has been identified that has the capacity to interact with this cytokine's unique tautomerase activity. This led us to hypothesize that MIF may have the capacity to interact with external substrates. We describe for the first time how Pseudomonas aeruginosa can utilize human recombinant MIF (rMIF) to significantly (P < 0.01) enhance its endogenous biofilm formation. Our in vivo studies demonstrate that utilizing a small-molecular-weight inhibitor targeting MIF's tautomerase activity (SCD-19) significantly reduces the inflammatory response in a murine pulmonary chronic P. aeruginosa model. In addition, we show that in in vitro experiments, pretreatment of P. aeruginosa with rMIF is associated with reduced bacterial killing by tobramycin. Our novel findings support the concept of an anti-MIF strategy that targets this enzymatic activity as a potential future antibacterial therapeutic approach.-Tynan, A., Mawhinney, L., Armstrong, M. E., O'Reilly, C., Kennedy, S., Caraher, E., Jülicher, K., O'Dwyer, D., Maher, L., Schaffer, K., Fabre, A., McKone, E. F., Leng, L., Bucala, R., Bernhagen, J., Cooke, G., Donnelly, S. C. Macrophage migration inhibitory factor enhances Pseudomonas aeruginosa biofilm formation, potentially contributing to cystic fibrosis pathogenesis.

Effect Of Game Design, Goal Type, And Player Numbers On The Physiological And Physical Demands Of Hurling-Specific Small-Sided Games, Shane Malone, Kieran Collins

Articles

The current study examined the effect that game design modification, goal type, and player numbers on the running performance and physiological demands of small-sided hurling games (SSG). Forty-eight hurling players (age, 25.5 ± 3.2 years; height, 178.9 ± 3.2 cm; body mass, 78.5 ± 4.5 kg) performed 4 types of SSG (possession [P], normal play [NP], regular goals [RG] and small goals [SG]) in 4-a-side, 5-a-side, and 6-a-side formats. Heart rate (Polar Electro Oy) and global positioning system technology (VX Sport, 4-Hz, Lower Hutt) were used to analyze the physical and physiological differences between SSG. Total distance (m), high-speed running …

Are Small-Sided Games An Effective Training Methodology For Improving Fitness In Hurling Players? A Comparative Study Of Training Methodologies, Shane Malone, Brian Hughes, Kieran Collins

Articles

The current investigation compared the effects of specific small-sided games training versus generic continuous aerobic training on team sport related exercise performances. Forty-eight hurling players (age: 25 ± 6.4 years; height: 180.2 ± 20.4 cm; mass: 80.5 ± 3.2 kg; V·O2max" role="presentation" style="display: inline; line-height: normal; word-spacing: normal; overflow-wrap: normal; white-space: nowrap; float: none; direction: ltr; max-width: none; max-height: none; min-width: 0px; min-height: 0px; border: 0px; padding: 0px; margin: 0px; position: relative;">V⋅O2maxV·O2max: 58.78 ± 3.05 ml·kg·min⁻¹) completed either traditional continuous aerobic training (n = 24) or team sport-specific small-sided game training (n = 24), consisting …

The Running Performance Profile Of Elite Gaelic Football Match-Play, Shane Malone, Barry Solan, Kieran Collins

Articles

The current study examined (a) the match running performance of Gaelic football and (b) the decrement in match running performance with respect to position. Global positioning satellite system technologies (4-Hz; VX Sport) were used with 3 elite intercounty teams across 3 full seasons with 250 full game data sets collected. Game movements were classified according to game actions and distance covered across speed zone thresholds (total distance [TD], high-speed running distance [HSRD; ≥17 km·h], sprint distance [SD; ≥22 km·h]; accelerations [n]; peak speed [km·h]). The influence of running performance in each quarter on the subsequent quarter was analyzed across all …

The Influence Of Match Outcome On Running Performance In Elite Gaelic Football, Shane Mangan, Shane Malone, Martin Ryan, Jason Mcgahan, Cian O'Neill, Con Burns, Joe Warne, Denise Martin, Kieran Collins

Articles

Introduction: Match outcome has been linked to running performance in many sports; however, the association has not yet been examined in Gaelic football. Methods: GPS technologies (4-Hz, VX Sport, Lower Hutt, New Zealand) were used with 5 elite Gaelic football teams over a period of 5 years (2012–2016), amounting to 95 matches. In total, 780 full match data sets were collected. Game movements were divided into total distance and high-speed distance (≥17 km h−1). Match outcomes were divided into big losses (≥6 points), small losses (≤5points), draws, small wins (≤5 points) and big wins (≥6 points). Results: Team (P …

The Relationship Between Technical Performance Indicators And Running Performance In Elite Gaelic Football, Shane Mangan, Martin Ryan, Simon Devenney, Aidan Shovlin, Jason Mcgahan, Shane Malone, Cian O'Neill, Con Burns, Kieran Collins

Articles

The aim of the current study was to assess whether technical performance relates to positional running demands of elite Gaelic football players. Over a period of three years (2014–2016), four elite Gaelic football teams were monitored using GPS technologies. Four hundred and thirty-two individual player samples were collected from 52 competitive matches. Video analysis software was used to code technical performance indicators in all games. Pearson’s correlations were performed between all technical variables and total distance (m) and high-speed distance (≥17 km h−1). Total ball in play time had small to medium effects (r = .233 to .390, p …

A Contemporary Multi-Modal Mechanical Approach To Training Monitoring In Elite Professional Soccer, Adam Owen, Leo Djaoui, Matthew Newton, Shane Malone, Bruno Mendes

Articles

Objectives: Understanding movements and mechanical demands of elite soccer players during training and competitive stressors is important for the support provision of player performance. Continued appreciation to quantify and monitor training load (TL) is apparent, however reporting multi-modal approaches in-line with competitive match-play demands remain limited. The investigation aimed to highlight a multimodal training monitoring method and its relationship to match-play. Subjects: 29 elite European soccer players participated were assessed (26.7 ± 4.07 years, height 183.4 ± 5.87 cm, body mass 78.4 ± 8.03 kg, 57.55 ± 5.32 ml.kg⁻¹.min⁻¹ and body composition 54.12 ± 13.65 mm) with daily …

The Electrochemical Deposition Of Zn-Mn Coating From Choline Choloride-Urea Deep Eutectic Solvent, Mihael Bucko, David Culliton, Tony Betts, Jelena Bajat

Articles

Electrochemical and microscopic techniques were used for characterization of Zn˗Mn coatings electrodeposited from choline chloride˗urea deep eutectic solvent. Cyclic voltammograms show that there was no discernible Mn reduction peak when only Mn2+ was present in DES solution. The distinct Mn peak developed only upon addition of Zn2+ to the solution, probably due to previous Zn nucleation on the steel substrate. It was found that 22-27 wt.% Mn, was deposited at current densities of 3-8 mA cm-2, amounts significantly higher than in aqueous electrolytes. Since higher deposition current densities resulted in the formation of a porous surface consisting of clusters of …

Enhancement Of Dielectric Properties With The Addition Of Bromine And Dopamine Modified Barium Titanate Particles To Silicone Rubber, Liang Jiang, David Kennedy, Stephen Jerrams, Tony Betts

Articles

Dual-coated barium titanate (BT) particles were prepared using dopamine (DP) in conjunction with bromine (Br) in order to enhance the dielectric constant of silicone rubber (SR) composites containing evenly distributed BT particles. The results showed that both DP and Br were deposited on the BT particles. The dielectric constant of the SR/BT composite was significantly increased from 3.6 to 4.7 at 1 kHz with the addition of BT modified with dopamine (DP–BT). Moreover, the dielectric constant further rose to 4.9 at 1 kHz when the DP–BT particle was grafted with bromine (Br–DP–BT).

The National Planning Framework 2040: Aspects On What It Takes To Sustain A Viable Rural Community, Brian Hughes

Articles

No abstract provided.

Doxorubicin Kinetics And Effects On Lung Cancer Cell Lines Using In-Vitro Raman Micro-Spectroscopy: Binding Signatures, Drug Resistance And Dna Repair, Hugh Byrne, Franck Bonnier, Alan Casey, Orla L. Howe, Zeineb Farhane

Articles

Raman micro-spectroscopy is a non-invasive analytical tool, whose potential in cellular analysis and monitoring drug mechanisms of action has already been demonstrated, and which can potentially be used in pre-clinical and clinical applications for the prediction of chemotherapeutic efficacy. To further investigate such potential clinical application, it is important to demonstrate its capability to differentiate drug mechanisms of action and cellular resistances. Using the example of Doxorubicin (DOX), in this study, it was used to probe the cellular uptake, signatures of chemical binding and subsequent cellular responses, of the chemotherapeutic drug in two lung cancer cell lines, A549 and Calu-1. …

Vibrational Spectroscopy As A Tool For Studying Drug-Cell Interaction: Could High Throughput Vibrational Spectroscopic Screening Improve Drug Development, Lauren E. Jamieson, Hugh Byrne

Articles

Vibrational spectroscopy is currently widely explored as a tool in biomedical applications. An area at the forefront of this field is the use of vibrational spectroscopy for disease diagnosis, ultimately aiming towards spectral pathology. However, while this field shows promising results, moving this technique into the clinic faces the challenges of widespread clinical trials and legislative approval. While spectral pathology has received a lot of attention, there are many other biomedical applications of vibrational spectroscopy, which could potentially be translated to applications with greater ease. A particularly promising application is the use of vibrational spectroscopic techniques to study the interaction …

Prediction Of Viral Loads For Diagnosis Of Hepatitis C Infection In Human Plasma Samples Using Raman Spectroscopy Coupled With Partial Least Squares Regression Analysis, Hugh Byrne, Franck Bonnier, H. Nawaz, N. Rashid, M. Saleem

Articles

Raman spectroscopy has been used to identify the biochemical changes associated with the presence of the Hepatitis C virus (HCV) in infected human blood plasma samples as compared with healthy samples, as control. The aim of the study was to establish the Raman spectral markers of hepatitis infection, which could be used for diagnostic purposes. Moreover, multivariate data analysis techniques, including Principal Component Analysis (PCA), coupled with Linear Discriminant Analysis (LDA), and Partial Least Square Regression (PLSR) are employed to further demonstrate the diagnostic capability of the technique. The PLSR model is developed to predict the viral loads of the …

Linking Atr-Ftir And Raman Features To Phenolic Extractability And Other Attributes In Grape Skin, Hugh Byrne, Abigail Rooney, Julio Nogales-Bueno, Jose Miguel Hernandez-Hierro, Francisco Jose Heredia

Articles

The importance of wine phenolics on the sensory characteristic of red wines is well-known. Therefore, it is necessary to control the extractability of phenolic compounds from grape skins, which depends significantly on grape ripeness and hence, on cell wall degradation.

In the present study, attenuated total reflectance Fourier transform infrared (ATR-FTIR) and Raman spectra of grape skin have been recorded. Then, these spectral matrices have been studied and the main spectral features have been linked to extractabilities of phenolic compounds (anthocyanins, flavanols and total phenols). Moreover, spectral differences between external and internal grape skin surfaces also have been studied.

It …

Determination Of Spectral Markers Of Cytotoxicity And Genotoxicity Using In Vitro Raman Microspectroscopy: Cellular Responses To Polyamidoamine Dendrimer Exposure, Esen Efeoglu, Alan Casey, Hugh Byrne

Articles

Although consumer exposure to nanomaterials is ever increasing, with potential increased applications in areas such as drug and/or gene delivery, contrast agents and diagnosis, determination of cyto- and geno- toxic effect of nanomaterials on human health and the environment still remains challenging. Although many techniques have been established and adapted to determine the cytotoxicity and genotoxicity of nano-sized materials, these techniques remain limited by the number of assays required, total cost, use of labels and they struggle to explain the underlying interaction mechanisms. In this study, Raman microspectroscopy is employed as an in vitro label free high content screening technique …

A Natural, Calcium-Rich Marine Multi-Material Complex Preserves Bone Structure, Composition And Strength In An Ovariectomized Rat Model Of Osteoporosis, Orlaith Brennan, Joseph Sweeney, Brian O'Meara, Amro Widaa, Franck Bonnier, Hugh Byrne, Denis O'Gorman, Fergal O'Brien

Articles

Calcium supplements are used as an aid in the prevention of osteopenia and osteoporosis and also for the treatment of patients when used along with medication. Many of these supplements are calcium carbonate based. This study compared a calcium-rich, marine multi-mineral complex (Aquamin) to calcium carbonate in an ovariectomised rat model of osteoporosis in order to assess Aquamin’s efficacy in preventing the onset of bone loss. Animals were randomly assigned to either non-ovariectomy control (Control), ovariectomy (OVX) plus calcium carbonate, ovariectomy plus Aquamin or ovariectomy plus Aquamin delay where Aquamin treatment started 8 weeks post OVX. At the end of …

Strengthening The Development Of The Short-Rotation Plantations Bioenergy Sector: Policy Insights From Six European Countries, Carlos Parra-Lopez, Martin Holley, Kevin Lindegaard, Samir Sayadi, Gonzalo Esteban-Lopez, Victor Duran-Zuazo, Christoph Knauer, Hans-Georg Von Engelbrechten, Ralf Winterber, Annika Henriksson, Annette Lamley, Anders Nylander, Susanne Paulrud, Pauline Leonard, Patrick Daly, Lukasz Drzewaszewski, Wojciech Rzewuski

Articles

This paper, based on a participatory methodological framework involving expert stakeholders and researchers from six European countries (Germany, Ireland, Poland, Spain, Sweden and UK), analyses the priority issues for the development of short-rotation plantations (SRP), and proposes a series of policy strategies to strengthen this development. The results indicate that there is a lack of awareness of the multifaceted benefits of SRP at the level of farmers, policy makers and public authorities. More research is required to put a value on the multifunctionality of SRP and justify its public support. Small-scale projects using established technologies are also required with energy …

The Question Of Fiction – Nonexistent Objects, A Possible World Response From Paul Ricoeur, Noel Fitzpatrick

Articles

The question of fiction is omnipresent within the work of Paul Ricoeur throughout his prolific career. However, Ricoeur raises the questions of fiction in relation to other issues such the symbol, metaphor and narrative. This article sets out to foreground a traditional problem of fiction and logic, which is termed the existence of non-existent objects, in relation to the Paul Ricoeur’s work on narrative. Ricoeur’s understanding of fiction takes place within his overall philosophical anthropology where the fictions and histories make up the very nature of identity both personal and collective. The existence of non-existent objects demonstrates a dichotomy between …

Directional Modulation For Compact Devices, Adam Narbudowicz, Max Ammann, Dirk Heberling

Articles

A new directional modulation system which uses radiation pattern data for modulation encoding is proposed. The approach allows compact multiport antennas (e.g. MIMO capable antennas) to be used for directional modulation, replacing extensive arrays. The modulation weighting coefficients are calculated with a fixed, antenna specific equation, thus reducing computational complexity. The solution is intended to enhance privacy in small, battery-operated wireless devices, required for “Internet of Things” applications.

Design Of A Compact, Fully-Autonomous 433 Mhz Tunable Antenna For Wearable Wireless Sensor Applications, John Buckley, Kevin Mccarthy, Domenico Gaetano, Loizos Loizou, Brendan O'Flynn, Cian O'Mathuna

Articles

The authors present the design of a tunable 433 MHz antenna that is tailored for wearable wireless sensor applications. This study first presents a detailed analysis of the measured impedance characteristics of a chosen antenna under test (AUT) in varying proximity to a human test subject. Instead of limiting the analysis to the head and hand only, this analysis measures the AUT impedance at varying distances from 11 different body positions. A novel antenna equivalent circuit model is then developed that enables both the free-space and total on-body AUT impedance variation to be rapidly computed using a circuit simulator instead …

Investigating Industry Expert Discourses On Aspirational Csr Communication, Lisa Koep

Articles

Purpose – The purpose of this paper is to investigate industry expert discourses on aspirational corporate social responsibility (CSR) communication. Analysing CSR managers’ and communication consultants’ talk about aspirational talk as constitutive of aspirational CSR communication, the data provide valuable insights into the dominant discourses, and draw attention to the manifold elements in the process of aspirational CSR communication. Design/methodology/approach – Data gathered during 11 in-depth, qualitative interviews with food industry experts in CSR and CSR communication roles in Ireland, the UK and the USA are studied. Findings – The analysis of industry expert discourses suggests that communicating CSR, and …

Justice Scalia, The Establishment Clause, And Christian Privilege, Caroline Mala Corbin

Articles

No abstract provided.

Who Really Said What? Mobile Historical Situated Documentary As Liminal Learning Space, Owen Gottlieb

Articles

This article explores the complexities and affordances of historical representation that arose in the process of designing a mobile augmented reality video game for teaching history. The process suggests opportunities to push the historical documentary form in new ways. Specifically, the article addresses the shifting liminal space between historical fiction narrative, and historical interactive documentary narrative. What happens when primary sources, available for examination are placed inside of a historically inspired narrative, one that hews closely to the events, but creates drama through dialogues between player and historical figure? In this relatively new field of interactive historical situated documentary, how …

Mode-Sum Prescription For The Vacuum Polarization In Odd Dimensions, Peter Taylor, Cormac Breen

Articles

We present a new mode-sum regularization prescription for computing the vacuum polarization of a scalar field in static spherically-symmetric black hole spacetimes in odd dimensions. This is the first general and systematic approach to regularized vacuum polarization in higher dimensions. Remarkably, the regularization parameters can be computed in closed form in arbitrary dimensions and for arbitrary metric function $f(r)$. In fact, we show that in spite of the increasing severity and number of the divergences to be regularized, the method presented is mostly agnostic to the number of dimensions. Finally, as an explicit example of our method, we show plots …

Regulating Secrecy, W. Nicholson Price Ii

Articles

Inventors face a stark choice between two intellectual property systems of protecting innovative ideas: patents and trade secrecy. But accounts of this choice underexplore the role of the regulators that dominate some areas of innovation. Regulation interacts with intellectual property exclusivity in socially problematic ways by encouraging secrecy at the expense of innovation, efficiency, and competition. This Article theorizes how regulation empowers intellectual property generally, explains why this strengthening is problematic for trade secrecy but not for patents, and offers the solution of regulator-enforced disclosure. When a regulator defines a product or a process, it becomes much harder to successfully …

Auditory Fatigue Model Applications To Predict Noise Induced Hearing Loss In Human And Chinchilla, Pengfei Sun, Daniel Fox, Kathleen Campbell, Jun Qin

Articles

Noise induced hearing loss (NIHL) remains a severe health problem worldwide. Current noise metrics and models have assessment limitations on gradually developing NIHL (GDNIHL). In this study, we apply a complex velocity level (CVL) auditory fatigue model to quantitatively assess the impact of basilar membrane (BM) movement on GDNIHL. The transfer functions of chinchilla and human auditory systems, including the triple-path nonlinear (TRNL) filters to simulate the inner ear responses, are applied to obtain BM velocity distribution. Chinchilla and human experimental hearing loss data are used to validate the proposed CVL model’s effectiveness. The results reveal that the developed CVL …

A French Take On Irish History : Histoire De L'Irlande : De 1912 Á Nos Jours' Review, Eamon Maher

Articles

No abstract provided.