Digital Commons Network^™

In Vitro Label Free Screening Of Chemotherapeutic Drugs Using Raman Micro-Spectroscopy: Towards A New Paradigm Of Spectralomics., Zeineb Farhane, Haq Nawaz, Franck Bonnier, Hugh Byrne

Articles

This overview groups some of the recent studies highlighting the potential application of Raman micro-spectroscopy as an analytical technique in preclinical development to predict drug mechanism of action and in clinical application as a companion diagnostic and in personalised therapy due to its capacity to predict cellular resistance and therefore to optimise chemotherapeutic treatment efficacy.

Notably, the anthracyclines, Doxorubicin and Actinomycin D, elicit similar spectroscopic signatures of subcellular interaction characteristic of the mode of action of intercalation. Although Cisplatin and Vincristine show markedly different signatures, at low exposure doses, their signatures at higher doses show marked similarities to those elicited …

Using Intellectual Property Law To Promote Human Flourishing For Market Women, J. Janewa Osei-Tutu

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No abstract provided.

Liberal Constitutionalism And Economic Inequality, Rosalind Dixon, Julie Suk

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Economic inequality is rising in democracies across the world and poses a clear threat to both the stability and legitimacy of liberal constitutional models. Can liberal constitutionalism respond to this threat? Or are there inherent limits to the liberal model that prevent an effective response? This Essay explores these questions by surveying the range of possible structural and rights-based constitutional responses to economic inequality, as well as possible obstacles to these responsesincluding problems of definition, leveling up versus down, unintended or counterproductive consequences, and institutional path dependence.

The Law Hasn't Yet Achieved Parity, Leah Litman

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Parity between men and women in the legal profession is an aspiration. It’s not reality, at least not yet. I wish I’d have understood that in law school because hearing that there’s parity when there’s none can be maddening. I also wish I would have known about the resources available to people who want to do something about the lack of parity in our profession.

Are Medicaid Work Requirements Legal?, Nicholas Bagley

Articles

On January 12, 2018, the Centers for Medicare & Medicaid Services (CMS) approved a waiver allowing Kentucky to impose a work requirement on some nondisabled Medicaid beneficiaries. Similar waivers are sure to follow. Supporters see work requirements as a spur to force the idle poor to work; opponents see the requirements as a covert means of withholding medical care from vulnerable people. Setting the policy debate aside, however, are work requirements legal?

Confocal Raman Spectroscopic Imaging For In Vitro Monitoring Of Active Ingredient Penetration And Distribution In Reconstructed Human Epidermis Model, Lynda Miloudi, Franck Bonnier, Ali Tfayli, Florent Yvergnaux, Hugh Byrne, Igor Chourpa, Emilie Munnier

Articles

Topically applied Active Cosmetic Ingredients (ACI) or Active Pharmaceutical Ingredients (API) efficacy is directly related to their efficiency of penetration in the skin. In vitro Reconstructed Human Epidermis (RHE) surrogate models offer in vivo like skin samples for transdermal studies. Using Delipidol®, an ACI currently used in the cosmetics industry, the capabilities to deliver accurate distribution maps and penetration profiles of this molecule by means of Confocal Raman spectroscopic Imaging have been demonstrated. Using a NCLS (Non negative constrained least squares) approach, contribution of specific molecules can be estimated at each point of spectral maps in order to deliver semi-quantitative …

Liminal Entrepreneuring: The Creative Practices Of Nascent Necessity Entrepreneurs, Lucia Garcia-Lorenzo, Paul Donnelly, Lucia Sell-Trujillo, J. Miguel Imas

Articles

This paper contributes to creative entrepreneurship studies through exploring ‘liminal entrepreneuring’, i.e., the organization-creation entrepreneurial practices and narratives of individuals living in precarious conditions. Drawing on a processual approach to entrepreneurship and Turner’s liminality concept, we study the transition from un(der)employment to entrepreneurship of 50 nascent necessity entrepreneurs (NNEs) in Spain, the United Kingdom, and Ireland. The paper asks how these agents develop creative entrepreneuring practices in their efforts to overcome their condition of ‘necessity’. The analysis shows how, in their everyday liminal entrepreneuring, NNEs disassemble their identities and social positions, experiment with new relationships and alternative visions of themselves, …

Two Deans Answer The Law School Wellness Questions They Hear The Most, Janet Stearns, David B. Jaffe

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No abstract provided.

The Fortification Of Inequality: Constitutional Doctrine And The Political Economy, Kate Andrias

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As Parts I and II of this Essay elaborate, the examination yields three observations of relevance to constitutional law more generally: First, judge-made constitutional doctrine, though by no means the primary cause of rising inequality, has played an important role in reinforcing and exacerbating it. Judges have acquiesced to legislatively structured economic inequality, while also restricting the ability of legislatures to remedy it. Second, while economic inequality has become a cause célèbre only in the last few years, much of the constitutional doctrine that has contributed to its flourishing is longstanding. Moreover, for several decades, even the Court’s more liberal …

Numerical Evaluation Of Microwave Thermal Ablation To Treat Small Adrenocortical Masses, G. Ruvio, J. Eaton-Evans, A. Shahzad, M. O’Halloran

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In this paper microwave thermal ablation is numerically evaluated in the context of a treatment for Conn’s Syndrome. This condition is caused by a benign shallow tumour in the cortex of adrenal gland. The modelling and design of microwave applicator to deliver thermal ablation to the adrenal gland requires accurate tissue characterisation. Measuring the dielectric properties of the constituent tissues in the adrenal gland, i.e. cortex and medulla, enables more accurate numerical modelling for electromagnetic and thermal simulations. This study presents an anatomically and dielectrically realistic numerical model of the adrenal gland, and investigates the feasibility of applying controlled heating …

Studies Of Geometrical Profiling In Fabricated Tapered Optical Fbers Using Whispering Gallery Modes Spectroscopy, Vishnu Kavungal, Gerald Farrell, Qiang Wu, Arun Kumar Mallik, Yuliya Semenova

Articles

This paper experimentally demonstrates a method for geometrical profiling of asymmetries in fabricated thin microfiber tapers with waist diameters ranging from ∼10 to ∼50µm with submicron accuracy. The method is based on the analysis of whispering gallery mode resonances excited in cylindrical fiber resonators as a result of evanescent coupling of light propagating through the fiber taper. The submicron accuracy of the proposed method has been verified by SEM studies. The method can be applied as a quality control tool in fabrication of microfiber based devices and sensors or for fine-tuning of microfiber fabrication set-ups.

John Mcgahern : Priceless Insights Into His Art, Eamon Maher

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John McGahern has been the subject of a number of monographs in recent years, but this is the first essay collection dedicated to his work since the three volumes of NUI Galway’s The John McGahern Yearbook, edited by John Kenny, and the critical essays assembled by Mullen, Bargroff and Mullen in a Peter Lang publication from 2013.

Judicial Mistakes In Discovery, Diego Zambrano

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No abstract provided.

High‐Frequency Trading And The New Stock Market: Sense And Nonsense, Merritt B. Fox, Lawrence R. Glosten, Gabriel V. Rauterberg

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The stock market has been transformed during the last 25 years. Human suppliers of liquidity like the NASDAQ dealers and NYSE specialists have been replaced by algorithmic market making; stocks that once traded on a single venue now trade across twelve exchanges and a multitude of alternative trading systems. New venues like dark pools, and new participants like high‐frequency traders, have emerged to take on prominent roles. This new market has had more than its share of controversy and regulatory scrutiny, particularly in the wake of Michael Lewis’s bestseller Flash Boys. In this article, the authors analyze five of the …

Is Qualified Immunity Unlawful?, William Baude

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No abstract provided.

Socialising Economic Development In Ireland: Social Enterprise An Untapped Resource, Gerard Joseph Doyle

Articles

The chapter provides a comprehensive explanatory framework outlining why social enterprises have been underutilised by policy-makers in Ireland. The Irish State has afforded social enterprise a narrow role in realising the State’s social and economic objectives. It is incumbent upon community organisations to demand that the State has a change of policy direction towards social enterprise, where its current residual role is replaced by a more central role in economic development. The chapter provides an analysis of the factors which led to the growth of the credit union movement in Ireland. Lessons from the development of Ireland’s credit union movement …

Cleaner Fuels For Ships Provide Public Health Benefits With Climate Tradeoffs, Mikhail Sofiev, James J. Winebrake, Lasse Johansson, Edward W. Carr, Marje Prank, Joana Soares, Julius Vira, Jukka-Pekka Jalkanen, James J. Corbett

Articles

We evaluate public health and climate impacts of low-sulphur fuels in global shipping. Using high-resolution emissions inventories, integrated atmospheric models, and health risk functions, we assess ship-related PM 2.5 pollution impacts in 2020 with and without the use of low-sulphur fuels. Cleaner marine fuels will reduce ship-related premature mortality and morbidity by 34 and 54%, respectively, representing a ~ 2.6% global reduction in PM 2.5 cardiovascular and lung cancer deaths and a ~3.6% global reduction in childhood asthma. Despite these reductions, low-sulphur marine fuels will still account for ~250k deaths and ~6.4 M childhood asthma cases annually, and more stringent …

A Fully Integrated Rssi And An Ultra-Low Power Sar Adc For 5.8 Ghz Dsrc Etc Transceiver, Meijuan Zhang, Ruifeng Liu, Yuanzhi Zhang, Wenshen Wang, Huimin Liu, Chao Lu

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This study presents a monolithic received signal strength indicator (RSSI) and an ultra-low power SAR ADC for 5.8 GHz DSRC transceiver in China electronic toll collection systems. In order to meet the stringent requirement of wide input range for the transceiver, two RSSIs collaborate with auxiliary ADC circuits to provide the digitalized received signal strength to the digital baseband of a transceiver. The RSSI design achieves fast transient response and low power consumption with a small die area by using internal active low-pass filters instead of external passive ones. The proposed design has been fabricated using a 0.13 μm 2P6M …

Partitioning Of Adipose Lipid Metabolism By Altered Expression And Function Of Ppar Isoforms After Bariatric Surgery, C Jahansouz, H Xu, A V. Hertzel, Kristin Ewing

Articles

BACKGROUND:

Bariatric surgery remains the most effective treatment for reducing adiposity and eliminating type 2 diabetes; however, the mechanism(s) responsible have remained elusive. Peroxisome proliferator-activated receptors (PPAR) encompass a family of nuclear hormone receptors that upon activation exert control of lipid metabolism, glucose regulation and inflammation. Their role in adipose tissue following bariatric surgery remains undefined.

RESULTS:

Within 7 days, bariatric surgery acutely drives a change in the activity and expression of PPARγ and PPARδ in subcutaneous adipose tissue thereby attenuating lipid storage, increasing lipolysis and potentiating lipid oxidation. This unique metabolic alteration leads to changes in downstream PPARγ/δ targets …

How To Lose A Constitutional Democracy, Aziz Huq, Tom Ginsburg

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No abstract provided.

Secrecy And Randomness: Encoding Cloud Data Locally Using A One-Time Pad, Paul Tobin, Lee Edward Tobin, Mick Mckeever, Jonathan Blackledge

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There is no secrecy without randomness, and we address poor cloud security using an analogue chaotic onetime pad encryption system to achieve perfect secrecy. Local encoding returns control to the client and makes stored cloud data unreadable to an adversary. Most cloud service providers encode client data using public encryption algorithms, but ultimately businesses and organisations are responsible for encoding data locally before uploading to the Cloud. As recommended by the Cloud Security Alliance, companies employing authentication and local encryption will reduce or eliminate, EU fines for late data breach discoveries when the EU implements the new general data protection …

Innovative Contracting For Pharmaceuticals And Medicaid’S Best-Price Rule, Nicholas Bagley

Articles

In recent years, drug manufacturers and private payers have expressed interest in novel pricing models that more closely link a drug’s price to its value. Indication-based pricing, outcome-based pricing, drug licenses, and drug mortgages have all been discussed as alternatives to paying strictly for volume. Manufacturers and payers have complained, however, that Medicaid’s “best-price rule” inhibits their ability to enter into these newpricing arrangements. This article examines the best-price rule and assesses to what extent, if any, it might frustrate the goal of paying for value. We conclude that the best-price rule is not as serious a problem as it …

Towards A Digital Earth: Using Archetypes To Enable Knowledge Interoperability Within Geo-Observational Sensor Systems Design, Paul Stacey, Damon Berry

Articles

Earth System Science (ESS) observational data are often inadequately semantically enriched by geo-observational information systems in order to capture the true meaning of the associated data sets. Data models underpinning these information systems are often too rigid in their data representation to allow for the ever-changing and evolving nature of ESS domain concepts. This impoverished approach to observational data representation reduces the ability of multi-disciplinary practitioners to share information in a computable way.

Object oriented techniques typically employed to model data in a complex domain (with evolving domain concepts) can unnecessarily exclude domain specialists from the design process, invariably leading …

Forfeiture Policy In The United States: Is There Hope For Reform, David Pimentel

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No abstract provided.

Partisan Balance With Bite, Daniel Hemel, Brian D. Feinstein

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No abstract provided.

Semi-Confidential Settlements In Civil, Criminal, And Sexual Assault Cases, Saul Levmore, Frank Fagan

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No abstract provided.

Economic Analysis In Labor Regulation, Hiba Hafiz

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No abstract provided.

Institutional Loyalties In Constitutional Law, Aziz Huq, David Fontana

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No abstract provided.

Investigation Of Temperature Response Of Photopolymer Material Used For Holographic Sensor, Muhammad Irfan Dr, Tatsiana Mikulchyk Dr, Suzanne Martin Dr, Izabela Naydenova Prof

Articles

Recently, functionalised photopolymer has emerged as a versatile recording material in the field of optical holography due to its novel characteristics and potential use in the development of holographic based sensors, and optical elements. This work describes the temperature response of a newly developed photopolymer, containing of a monomer Nisopropylacrylamide (NIPA) which under photopolymerisation forms a temperature sensitive polymer - Poly(Nisopropylacrylamide) (PNIPA). The photonic sensor was developed by holographic recording of volume phase transmission gratings in a self-processing NIPA-based polymer with a 532 nm laser beam. A 633 nm probe beam was used to monitor real time diffraction efficiency (DE) …

Gender Representation In Children’S Books: Case Of An Early Childhood Setting, Katarina Filipovic

Articles

The purpose of this small-scale case study was to identify and analyze key patterns in terms of gender representation in children’s books in one early childhood setting. Furthermore, this case study sought to understand the perspectives of early childhood educators on gender representation in children’s books. The researcher employed multiple methods of data collection, including content analysis of 15 children’s books, as well as reflective journal writing and professional conversation between eight educators from one early childhood center in Dublin, Ireland. Content analysis of children’s books revealed distinct gender patterns that include underrepresentation of female characters and instances of gender …