Digital Commons Network^™

Enzymatic Extraction Of Fucoxanthin From Brown Seaweeds, Emer Shannon, Nissreen Abu-Ghannam

Articles

Brown seaweeds contain a number of bioactive compounds. The xanthophyll, fucoxanthin, has in vivo efficacy against disorders such as type 2 diabetes, obesity and cancer. Organic solvents are traditionally employed to extract fucoxanthin, but carry a toxic chemical and environmental burden. The aim of this study was to optimise a fucoxanthin extraction method using enzymes, water, low-temperature dehydration and mechanical blending, to produce yields comparable to those achieved with an organic solvent (acetone). Response surface methodology was applied, using Fucus vesiculosus as a model species. A fucoxanthin yield of 0.657 mg g^-1 (dry mass) was obtained from F. …

Holographic Beam-Shaping Diffractive Diffusers Fabricated By Using Controlled Laser Speckle, Kevin Murphy, Vincent Toal, Izabela Naydenova, Suzanne Martin

Articles

A method for fabricating diffractive holographic optical diffusers is reported, allowing a high degree of control of the resulting diffuser characteristics. The method consists of recording a laser speckle pattern using a single carrier beam, with controlled speckle size and shape, in an acrylamide-based volume photopolymer. The multiple interferences that create the speckle pattern form the hologram. Results are presented verifying the diffusers are volume holographic in nature and the speckle pattern is recorded accurately in the photopolymer. Diffusers recorded by this method are analysed to characterise the optical performance of the diffusers and to illustrate their beam-shaping capabilities, particularly …

Quantifying Partisan Gerrymandering: An Evaluation Of The Efficiency Gap Proposal, Benjamin Plener Cover

Articles

Electoral districting presents a risk of partisan gerrymandering: the manipulation of electoral boundaries to favor one political party over another. For three decades, the U.S. Supreme Court has failed to settle on a legal test for partisan gerrymandering, and such claims have uniformly failed. Until recently. Plaintiffs prevailed before a three-judge federal panel in Wisconsin by leveraging a new measure called the "efficiency gap," which quantifies partisan gerrymandering in terms of two parties' relative efficiency at translating votes for their party into seats in government. The case is now before the Court, which may embrace the efficiency gap approach and …

Studying The Effect Of Froude Number And Densimetric Froude Number On Local Scours Around Circular Bridge Piers, Md Abdullah Al Faruque

Articles

A very large percentage of bridge failures are attributed to scouring around bridge piers and this directly influences public safety. Experiments are carried out in a 12-m long rectangular open channel flume made of transparent tempered glass. A 300 mm thick bed made up of sand particles is leveled horizontally to create the test bed and a 50 mm hollow plastic cylinder is used as a model bridge pier. Tests are carried out with varying flow depths and velocities. Data points of various scour parameters such as scour depth, width, and length are collected based on different flow conditions and …

Toll-Like Receptor 3 L412f Polymorphism Promotes A Persistent Clinical Phenotype In Pulmonary Sarcoidosis, Gordon Cooke, Ijaz Kamal, Monika Strengert, Emily Hams, Leona Mawhinney, Aisling Tynan, Ciaran O’ Reilly, David N. O’ Dwyer, Steven L. Kunkel, Ulla G. Knaus, Denis C. Shields, David R. Moller, Andrew G. Bowie, Padraic G. Fallon, Cory M. Hogaboam, Michelle E. Armstrong, Seamas C. Donnelly

Articles

Background: Sarcoidosis is a multisystemic disorder of unknown etiology, characterised by the

presence of non-caseating granulomas in target organs. In ninety percent of cases, there is

thoracic involvement. Fifty to seventy percent of pulmonary sarcoidosis patients will experience

acute, self-limiting disease. For the subgroup of patients who develop persistent disease, no

targeted therapy is currently available.

Aim: To investigate the potential of the single nucleotide polymorphism (SNP), Toll-like

receptor 3 Leu412Phe (TLR3 L412F; rs3775291), as a causative factor in the development of,

and in disease persistence in pulmonary sarcoidosis. To investigate the functionality of TLR3

L412F in vitro in …

Limited Distribution Networks Stifle Competition In The Generic And Biosimilar Drug Industries, Laura Karas, Kenneth M. Shermock, Celia Proctor, Mariana Socal, Gerard F. Anderson

Articles

A limited distribution network (LDN) restricts the distribution channel for a pharmaceutical drug to 1 or a very small number of distributors. This strategy may allow for more effective allocation of drugs in shortage and is purported to help ensure the safe distribution of high-risk drugs to small patient populations. However, in recent years, some drug companies, including Turing Pharmaceuticals, have used LDNs to prevent generic and biosimilar companies from accessing samples of drug products necessary to perform testing required by the FDA for generic and biosimilar drug applications. LDNs also hamper provider access to pharmaceuticals and facilitate price gouging. …

The Influence Of Government Defenders On Affirmative Civil Rights Enforcement, Alexander A. Reinert

Articles

The federal government — in particular the Department of Justice — can be one of the most efficient and powerful vindicators of civil rights, while simultaneously one of the most effective advocates for imposing barriers to affirmative civil rights enforcement. At the same time that the DOJ’s Civil Rights Division (CRD) is entering federal court to vindicate important rights, attorneys in the Civil Division (either from Main Justice or in any number of U.S. Attorney’s offices) are appearing in court to prevent the same. No doubt a similar pattern can be observed in certain state governments that have active affirmative …

The Politics Of Access: Examining Concerted State/Private Enforcement Solutions To Class Action Bans, Myriam E. Gilles

Articles

Procedural and substantive constraints on the ability of ordinary people to access the civil justice system have become all too commonplace. The “justice gap” owes much to cuts in funding for legal aid and court administration, heightened pleading standards, ever-rising costs of discovery, increasingly restrictive views on standing to sue, and the co-opting of small claims court by businesses seeking to collect debts, among other obstacles in the path to the courthouse. But the most consequential impediment, surely, is the enforcement of mandatory arbitration clauses with class action bans, which bar consumers and employees from bringing or being represented in …

Section 2 After Section 5: Voting Rights And The Race To The Bottom, Ellen D. Katz

Articles

Five years ago, Shelby County v. Holder released nine states and fifty-five smaller jurisdictions from the preclearance obligation set forth in section 5 of the Voting Rights Act (VRA). This obligation mandated that places with a history of discrimination in voting obtain federal approval—known as preclearance—before changing any electoral rule or procedure. Within hours of the Shelby County decision, jurisdictions began moving to reenact measures section 5 had specifically blocked. Others pressed forward with new rules that the VRA would have barred prior to Shelby County.

The Jus Ad Bellum's Regulatory Form, Monica Hakimi

Articles

This article argues that a form of legal regulation is embodied in decisions at the UN Security Council that condone but do not formally authorize specific military operations. Such decisions sometimes inflect or go beyond what the jus ad bellum permits through its general standards—that is, under the prohibition of cross-border force and small handful of exceptions. Recognizing that this form of regulation is both part of the law and different in kind from regulation through the general standards should change how we think about the jus ad bellum.

Toxicological Assessment Of Nanomaterials: The Role Of In Vitro Raman Microspectroscopic Analysis, Esen Efeoglu, Marcus Maher, Alan Casey, Hugh Byrne

Articles

The acceleration of nanomaterials research has brought about increased demands for rapid analysis of their bioactivity, in a multi-parametric fashion, to minimise the gap between potential applications and knowledge of their toxicological properties. The potential of Raman microspectroscopy for the analysis of biological systems with the aid of multivariate analysis techniques has been demonstrated. In this study, an overview of recent efforts towards establishing a ‘label-free high content nanotoxicological assessment technique’ using Raman microspectroscopy is presented. The current state of the art for cellular toxicity assessment and the potential of Raman microspectroscopy are discussed, and the spectral markers of the …

Dueling Denominators And The Demise Of Lucas, Stewart E. Sterk

Articles

In Murr v. Wisconsin, the Supreme Court outlined a process for ascertaining the denominator in takings cases – an issue that arises both with respect to Penn Central takings claims and Lucas takings claims. The underpinnings of Penn Central claims and Lucas claims are not identical; Penn Central’s primary concern is assuring fairness to landowners, while the focus of Lucas is on restricting government efforts to bypass the condemnation process. Although this difference in focus might suggest a difference in appropriate denominator, the Court’s multi-factor balancing approach apparently applies to all takings claims. Although the Court’s approach is consistent with …

Dispute System Design Can Help: To Bring About The Future Envisioned By Gpc Participants, We Need To Change The Structure Of What We Do, Lela P. Love, Lisa Blomgren Amsler, Mansi Karol

Articles

No abstract provided.

Pardoning Immigrants, Peter L. Markowitz, Lindsay Nash

Articles

In the waning days of the Obama Administration, with Trump’s promised immigration crackdown looming, over one hundred advocacy organizations joined forces to urge President Obama to permanently protect hundreds of thousands of immigrants from deportation by pardoning their breaches of civil immigration law. That pardon never materialized and, as expected, the Trump enforcement regime is sowing terror and devastation in immigrant communities nationwide. While it seems unfathomable that the current president would use his pardon power to mitigate even the most extreme applications of our nation’s immigration laws, there is unfortunately no indication that the harshest aspects of the immigration …

Cold Atmospheric Plasma Induces Atp-Dependent Endocytosis Of Nanoparticles And Synergistic U373mg Cancer Cell Death, Zhonglei He, Kangze Liu, Eline Manaloto, Alan Casey, George P. Cribaro, Hugh Byrne, Furong Tian, Carlos Barcia, Gillian Conway, Patrick J. Cullen, James Curtin

Articles

Gold nanoparticles (AuNP) have potential as both diagnostic and therapeutic vehicles. However, selective targeting and uptake in cancer cells remains challenging. Cold atmospheric plasma (CAP) can be combined with AuNP to achieve synergistic anti-cancer cytotoxicity. To explore synergistic mechanisms, we demonstrate both rate of AuNP uptake and total amount accumulated in U373MG Glioblastoma multiforme (GBM) cells are signifcantly increased when exposed to 75kV CAP generated by dielectric barrier discharge. No signifcant changes in the physical parameters of AuNP were caused by CAP but active transport mechanisms were stimulated in cells. Unlike many other biological efects of CAP, long-lived reactive species …

Angular Lens, Rishabh Sahu, Swati Chaudhary, Kedar Khare, Mishkatul Bhattacharya, Harshawardhan Wanare, Anand K. Jha

Articles

We propose a single phase-only optical element that transforms different orbital angular momentum (OAM) modes into localized spots at separated angular positions on a transverse plane. We refer to this element as an angular lens since it separates out OAM modes in a manner analogous to how a converging lens separates out transverse wave-vector modes at the focal plane. We also simulate the proposed angular lens using a spatial light modulator and experimentally demonstrate its working. Our work can have important implications for OAM-based classical and quantum communication applications.

Why Wikipedia Often Overlooks Stories Of Women In History, Lara Nicosia, Tamar Carroll

Articles

Wikipedia's reliance on a volunteer editing base has resulted in a gender bias both in the quantity and quality of content around women. With less than 20% of Wikipedia's editors identifying as women, only 30% of biographical entries have been written about women and entries on women tend to be shorter and more focused on relationships and family roles than entries on men. This article explores the causes of Wikipedia's gender bias and offers ways that both individuals and institutions can help improve Wikipedia's content around women.

Preparation And Physical Properties Of Functional Barium Carbonate Nanostructures By A Facile Composite-Hydroxide-Mediated Route, Tauseef Shahid, Muhammad Arfan, Aurang Zeb, Tayyaba Bibi, Taj Muhammad Khan

Articles

In recent years, nanotechnology has given birth to numerous nanomaterials due to their increased use in various sectors of research and development. To produce these nanomaterials, nanotechnology further has opened several rooms for the potential novel methods. Composite-hydroxide-mediated (CHM) method is one of the recent chemical synthesis routes that have gained considerable importance in research due to their effortlessness and versatile nature, covering a broad range of nanomaterials to prepare.

Interdisciplinary Teaching And Learning Within Molecular Gastronomy Education: Does It Benefit Students?, Roisin Burke, Pauline Danaher

Articles

Since the creation of Molecular Gastronomy (MG) as a scientific discipline in 1988 a variety of higher education modules and programmes in that discipline have developed around the world. At the Technological University Dublin, MG has been taught using an interdisciplinary approach since the academic year 2012/2013. A Culinary Science lecturer and a Culinary Arts lecturer work in synergy and teach an interdisciplinary group of Food Science (FS) and Culinary Arts (CA) students. The students’ work is assessed, in each academic year, using summative methods i.e. written exam and a project assignment. In the academic year 2016/2017 the assignment reports …

The Living Anti-Injunction Act, Daniel Hemel

Articles

No abstract provided.

Institutional Determinants Of Environmental Corporate Social Responsibility: Are Multinational Entities Taking Advantage Of Weak Environmental Enforcement In Lower-Income Nations?, Stephen R. Luxmore, Clyde Eiríkur Hull, Zhi Tang

Articles

Multinational enterprises (MNEs) are often accused of taking advantage of lax environmental regulations in developing countries. However, no quantitative analysis of the impact of doing business in nations of different income levels on environmental corporate social responsibility (ECSR) has been done prior to this study. Incorporating institutional factors in our approach, we argue that endoisomorphic and exoisomorphic pressures relating to ECSR impact MNEs differently according to the MNEs’ level of activity in low-, lower-middle-, upper-middle-, and high-income nations. We predict and, using data from 113 companies, find that selling in poorer nations is positively associated with increased levels of ECSR. …

Institutional Determinants Of Environmental Corporatesocial Responsibility: Are Multinational Entities Taking Advantage Of Weak Environmental Enforcement In Lower-Income Nations?, Stephen R. Luxmore, Clyde Eiríkur Hull, Zhi Tang

Articles

Multinational enterprises (MNEs) are often accused of taking advantage of lax environmental regulations in developing countries. However, no quantitative analysis of the impact of doing business in nations of different income levels on environmental corporate social responsibility (ECSR) has been done prior to this study. Incorporating institutional factors in our approach, we argue that endoisomorphic and exoisomorphic pressures relating to ECSR impact MNEs differently according to the MNEs' level of activity in low‐, lower‐middle‐, upper‐middle‐, and high‐income nations. We predict and, using data from 113 companies, find that selling in poorer nations is positively associated with increased levels of ECSR. …

Investigating Secondary Students Beliefs About Mathematical Problem-Solving, Mark Prendergast, Cormac Breen, Aibhin Bray, Fiona Faulkner, Brian Carroll, Dominic Quinn

Articles

Many studies over the past thirty years have highlighted the important role of students’ beliefs for successful problem solving in mathematics. Given the recent emphasis afforded to problem solving on the reformed Irish secondary school mathematics curriculum, the main aim of this study was to identify Irish students’ (n = 975) beliefs about the field. A quantitative measure of these beliefs was attained through the use of the Indiana Mathematical Belief Scale, an existing thirty item (five scale) self-report questionnaire. A statistical analysis of the data revealed that students who were further through their secondary education had a stronger belief …

Discriminating Gasoline Fuel Contamination In Engine Oil By Terahertz Time-Domain Spectroscopy, Ali Mazin Abdul-Munaim, Mario Mendez Aller, Sascha Preu, Dennis G. Watson

Articles

Gasoline engine oil (SAE 5W20) was contaminated with four levels (0%, 4%, 8% and 12%) of gasoline fuel and submitted to terahertz time-domain spectroscopy (THz-TDS). Three sampling methods were used to compare measurement variations. For all sampling methods, refractive index decreased with increased fuel contamination and absorption coefficient increased with increased fuel contamination. Absorption coefficients were significantly different for each fuel contamination level for each sampling method across the entire 0.5–2.5 THz range. The frequency of 0.5 THz produced the best model of absorption coefficient predicting fuel contamination with a rootmean- square error of 0.21% points. THz-TDS demonstrated high potential …

Impact Of Supplemental Oxygen On Obstructive Sleep Apnea Of Infants, Piyush Das, R Kashyap, S Kotagal

Articles

Abstract: Treatment options may be limited for infants with obstructive sleep apnea when there is no surgically correctable upper airway lesion. We therefore evaluated, retrospectively, the efficacy of low-flow oxygen as a therapeutic option for infant obstructive sleep apnea. We reviewed the medical charts of 23 infants who had undergone a therapeutic trial of low-flow oxygen during polysomnography. Split-night polysomnography was used in 21/23 subjects while 2/23 had undergone two separate, full-night polysomnography sleep architecture and respiratory findings on the baseline polysomnogram segment that was obtained in room air were compared with the segment on low-flow oxygen (0.25–1 L/min). Wilcoxon …

Dermot Healy's Endless Quest For The Absolute, Eamon Maher

Articles

No abstract provided.

Accountability Claims In Constitutional Law, Nicholas Stephanopoulos

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No abstract provided.

The Coming Demise Of Liberal Constitutionalism?, Aziz Huq, Tom Ginsburg, Mila Versteeg

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No abstract provided.

Reframing The Mediation Debate In Irish All-Issues Divorce Disputes: From Mediation Vs. Litigation To Mediation And Litigation, Deirdre Mcgowan

Articles

Mediation currently plays a minor role in the Irish family justice system, yet a policy consensus exists that more couples should be encouraged to mediate and that increased rates of mediation will reduce the numbers seeking redress through the courts. The recently published Mediation Act 2017 adopts this position, assuming that the provision of information on mediation will increase uptake and that mediation offers an alternative to litigation for most civil disputes. This article reviews attempts in Ireland, England and Wales to encourage family disputants to mediate, identifying weaknesses in the information strategy. It also examines the legal framework governing …

Courts’ Limited Ability To Protect Constitutional Rights, Adam S. Chilton, Mila Versteeg

Articles

No abstract provided.