Digital Commons Network^™

Limits Of Detection Of Mycotoxins By Laminar Flow Strips: A Review, Xinyi Zhao, Hugh Byrne, Christine M. O’Connor, James Curtin, Furong Tian

Articles

Mycotoxins are secondary metabolic products of fungi. They are poisonous, carcinogenic, and mutagenic in nature and pose a serious health threat to both humans and animals, causing severe illnesses and even death. Rapid, simple and low-cost methods of detection of mycotoxins are of immense importance and in great demand in the food and beverage industry, as well as in agriculture and environmental monitoring, and, for this purpose, lateral flow immunochromatographic strips (ICSTs) have been widely used in food safety and environmental monitoring. The literature to date describing the development of ICSTs for the detection of different types of mycotoxins using …

Pt Symmetry, Induced Mechanical Lasing, And Tunable Force Sensing In A Coupled-Mode Optically Levitated Nanoparticle, Sandeep Sharma, A. Kani, Mishkatul Bhattacharya

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We theoretically investigate PT symmetry, induced mechanical lasing, and force sensing in an optically levitated nanoparticle with coupled oscillation modes. The coupling in the levitated system is created by the modulation of an asymmetric optical potential in the plane transverse to the beam trapping the nanoparticle. We show that such a coupling can lead to PT -symmetric mechanical behavior for experimentally realistic parameters. Further, by examining the phonon dynamics and the second-order coherence of the nanoparticle modes, we determine that induced mechanical lasing is also possible. Finally, we demonstrate that tunable ultrasensitive force sensing (∼zN/ √H z) can be engineered …

Pt Symmetry, Induced Mechanical Lasing, And Tunable Force Sensing In A Coupled-Mode Optically Levitated Nanoparticle, Sandeep Sharma, A. Kani, Mishkat Bhattacharya

Articles

We theoretically investigate PT symmetry, induced mechanical lasing, and force sensing in an optically levitated nanoparticle with coupled oscillation modes. The coupling in the levitated system is created by the modulation of an asymmetric optical potential in the plane transverse to the beam trapping the nanoparticle. We show that such a coupling can lead to PT-symmetric mechanical behavior for experimentally realistic parameters. Further, by examining the phonon dynamics and the second-order coherence of the nanoparticle modes, we determine that induced mechanical lasing is also possible. Finally, we demonstrate that tunable ultrasensitive force sensing (∼zN/√Hz) can be engineered in the system. …

Autonomous Vehicle Regulation & Trust: The Impact Of Failures To Comply With Standards, William H. Widen, Phillip Koopman

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The autonomous vehicle (AV) industry works very hard to create public trust in both AV technology and its developers. Building trust is part of a strategy to permit the industry itself to manage the testing and deployment of AV technology without regulatory interference. This article explains how industry actions to promote trust (both individually and collectively) have created concerns rather than comfort with this emerging technology. The article suggests how the industry might change its current approach to law and regulation from an adversarial posture to a more cooperative one in which a space is created for government regulation consistent …

A New Framework For Digital Taxation, Reuven Avi-Yonah, Young Ran (Christine) Kim, Karen Sam

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The international tax regime has wide implications for business, trade, and the international political economy. Under current law, multinational enterprises do not pay their fair share of taxes to market countries where profits are generated because market countries are only allowed to tax companies with a physical presence there. Digital companies, like Google and Amazon, can operate entirely online, thereby avoiding market country taxes. Multinationals can also exploit existing tax rules by shifting their profits to low-tax jurisdictions, thereby avoiding taxes in the residence country where their headquarters are located.

Recently, a global tax deal was reached to tackle these …

The Deep Architecture Of American Covid-19 Tort Reform 2020-21, Anthony J. Sebok

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The rapid emergence of the COVID-19 pandemic produced massive state actions to protect in public health through the exercise of the police powers by local, state and national governments. In the United States there were calls early in the crisis to exercise the state’s power over tort law: As early as April 2020, the American Tort Reform Association published a White Paper, Responding to the Coming Lawsuit Surge that called for “reasonable constraints on . . . lawsuits that pose an obstacle to the coronavirus response effort, place businesses in jeopardy, and further damage the economy.”

This article, prepared for …

Vacuum Uv (Vuv) Photo-Oxidation Of Polyethersulfone (Pes), Sarah Oakes, Ryan Keeley, Hunter Heineman, Tom Allston, Joel Shertok, Michael Mehan, Gregory K. Thompson, Gerald A. Takacs

Articles

International need for water quality is placing a high demand on separation technology to develop advanced oxidative processes for polyethersulfone (PES) membranes to help improve water purification. Therefore, VUV photo-oxidation with a low pressure Ar plasma was studied to improve the hydrophilicity of PES by flowing oxygen over the surface during treatment. X-ray photoelectron spectroscopy (XPS) detected a decrease in the C at% (4.4 ± 1.7 at%), increase in O at% (3.7 ± 1.0 at%), and a constant S at% (5.4 ± 0.2 at%). Curve fitting of the XPS spectra showed a decrease in sp2 C-C aromatic group bonding, and …

Big Data Analysis Of Vision Screening Standards Used To Evaluate Fitness To Drive, Michael Moore, John Butler, Daniel Ian Flitcroft, James Loughman

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Purpose: Visual acuity (VA) assessment is the most commonly performed vision screening method for drivers. The standards and repeat assessment intervals used, however, are arbitrary, lack an evidence base and are highly variable across different countries. This study utilizes the power of Big Data to provide evidence-based recommendations for standardized driver vision screening.

Methods: Anonymized electronic medical record data were gathered from 40 Irish optometry practices comprising 81,184 unique patients. A Kaplan-Meier Survival (KMS) analysis was used to determine the effect of increasing age and time since screening on the likelihood of passing the VA standard for driving. A logistic …

Detecting Iot Attacks Using An Ensemble Machine Learning Model, Vikas Tomar, Sachin Sharma

Articles

Malicious attacks are becoming more prevalent due to the growing use of Internet of Things (IoT) devices in homes, offices, transportation, healthcare, and other locations. By incorporating fog computing into IoT, attacks can be detected in a short amount of time, as the distance between IoT devices and fog devices is smaller than the distance between IoT devices and the cloud. Machine learning is frequently used for the detection of attacks due to the huge amount of data available from IoT devices. However, the problem is that fog devices may not have enough resources, such as processing power and memory, …

Essays On Good Practice In Academic Writing: A Comparison Across Business Disciplines, Rawayda Abdou, Kevin Paul Corbett, Elun Hack, Deirdre Mcquillan

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This is a series of essays to support PhD students and early career researchers within the field of business. By delving into a cross disciplinary perspective on academic writing in the business domain, researchers will better understand differences for writing. Essay 1 highlights what is important for writing in economics. Essay 2 adopts a different approach by arguing for more pluralism and applied approaches when writing in Human Resource Management. The essay opens up new possibilities and opportunities for PhD students and early career researchers interested in more applied approaches. Essay 3 guides qualitative researchers writing in sports management where …

Adapting To 4 Degrees C World, Karrigan Bork, Karen Bradshaw, Cinnamon P. Carlarne, Robin Kundis Craig, Sarah Fox, Josh Galperin, Keith Hirokawa, Shi-Ling Hsu, Katrina Kuh, Kevin Lynch, Michele Okoh, Jessica Owley, Melissa Powers, Shannon Roesler, J.B. Ruhl, James Salzman, David Takacs, Clifford J. Villa

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The Paris Agreement's goal to hold warming to 1.50-2 0 C above pre-industrial levels now appears unrealistic. Profs. Robin Kundis Craig and J.B. Ruhl have recently argued that because a 40 C world may be likely, we must recognize the disruptive consequences of such a world and respond by reimagining governance structures to meet the challenges of adapting to it. In this latest in a biannual series of essays, they and other members of the Environmental Law Collaborative explore what 40 C might mean for a variety of current legal doctrines, planning policies, governance structures, and institutions.

Advancing Ubiquitous Collaboration For Telehealth - A Framework To Evaluate Technology-Mediated Collaborative Workflow For Telehealth, Hypertension Exam Workflow Study, Christopher Bondy Ph.D., Linlin Chen Ph.D, Pamela Grover Md, Pengcheng Shi Ph.D

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Healthcare systems are under siege globally regarding technology adoption; the recent pandemic has only magnified the issues. Providers and patients alike look to new enabling technologies to establish real-time connectivity and capability for a growing range of remote telehealth solutions. The migration to new technology is not as seamless as clinicians and patients would like since the new workflows pose new responsibilities and barriers to adoption across the telehealth ecosystem. Technology-mediated workflows (integrated software and personal medical devices) are increasingly important in patient-centered healthcare; software-intense systems will become integral in prescribed treatment plans [1]. My research explored the path to …

Childminding Professionalism And Professionalisation In Ireland: A Different Story, Miriam O'Regan, Ann Marie Halpenny, Noirin Hayes

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This research focussed on documenting the praxis and paedagogy of paid, professional childminding (family childcare/day care) in Ireland. It explored professionalism and professionalisation among childminders in the context of the evolving understanding of professionalism in Early Childhood Education and Care (ECEC) nationally and internationally. The research was conducted within the framework of Ecocultural Theory (ECT) on the eve of mandatory regulation of childminding against the backdrop of Irish ECEC policy. A mixed method approach was adopted, using the Ecocultural Family Interview for Childminders (EFICh), including participants’ photographs, case study surveys, researcher field notes and holistic ratings. We present findings related …

Towards An Ethical Framework For The Design And Development Of Inclusive Home-Based Smart Technology For Smart Spaces For Older Adults And People With Disabilities, Emma Murphy, Julie Doyle, Ioannis Stavrakakis, Damian Gordon, Brian Keegan, Dympna O'Sullivan

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Unique ethical, privacy and safety implications arise for people who are reliant on home-based smart technology due to health conditions or disabilities. As a result we need to carefully reflect on our approaches to ethical issues over the life cycle of smart home technology design and the wider living context for end users and relevant stakeholders. In this position paper we highlight a need for a reflective, inclusive ethical framework for the design of inclusive smart spaces. We present key ethical considerations in the design, development and deployment of smart home-based technology for older adults and people with disabilities. We …

Age Specific Models To Capture The Change In Risk Factor Contribution By Age To Short Term Primary Ischemic Stroke Risk, Elizabeth Hunter, John D. Kelleher

Articles

Age is one of the most important risk factors when it comes to stroke risk prediction. However, including age as a risk factor in a stroke prediction model can give rise to a number of difficulties. Age often dominates the risk score, and also not all risk factors contribute proportionally to stroke risk by age. In this study we investigate a number of common stroke risk factors, using Framingham heart study data from the NHLBI Biologic Specimen and Data Repository Information Coordinating Center to determine if they appear to contribute proportionally by age to a stroke risk score. As we …

Using Phreeqc To Model Cement Hydration, Niall Holmes Dr., Mark Tyrer, Roger P. West Prof, Aaron Lowe, Denis Kelliher

Articles

This paper presents the steps involved in undertaking an analysis of hydrating cements with different levels of limestone powder using the PHREEQC geochemical software with the Notepad++ editor. The analysis begins with determining which solid phases are thermodynamically predicted to precipitate and form using the oxide compositions of commercial CEM I and CEM II/A-L cements. When the phases are known, PHREEQC is programmed to provide predictions of the phase dissolution and phase assemblage over time (here, 1000 days of hydration) as well as the pore solution chemistry. Thermodynamics has been successfully applied to the field of cement hydration to predict …

Extracellular Secretion Of A Cutinase With Polyester-Degrading Potential By E. Coli Using A Novel Signal Peptide From Amycolatopsis Mediterranei, Yeqi Tan, Gemma K. Kinsella, Gary T. Henehan, Barry J. Ryan

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Recent studies in this laboratory showed that an extracellular cutinase from A. mediterranei (AmCut) was able to degrade the plastics polycaprolactone and polybutylene succinate. Such plastics can be slow to degrade in soils due to a lack of efficient polyester degrading organisms. AmCut also showed potential for the biocatalytic synthesis of esters by reverse hydrolysis.

The gene for AmCut has an upstream leader sequence whose transcript is not present in the purified enzyme. In this study, we show using predictive modelling, that this sequence codes for an N-terminal signal peptide that directs transmembrane expression via the Sec secretion pathway.

E. …

Detecting Patches On Road Pavement Images Acquired With 3d Laser Sensors Using Object Detection And Deep Learning, Syed Ibrahim Hassan, Dympna O'Sullivan, Susan Mckeever, Kieran Feighan, David Power, Ray Mcgowan

Articles

Regular pavement inspections are key to good road maintenance and road defect corrections. Advanced pavement inspection systems such as LCMS (Laser Crack Measurement System) can automatically detect the presence of different defects using 3D lasers. However, such systems still require manual involvement to complete the detection of pavement defects. This paper proposes an automatic patch detection system using object detection technique. To our knowledge, this is the first time state-of-the-art object detection models Faster RCNN, and SSD MobileNet-V2 have been used to detect patches inside images acquired by LCMS. Results show that the object detection model can successfully detect patches …

Contracts In The Age Of Smart Readers, Yonathan A. Arbel, Shmuel I. Becher

Articles

What does it mean to have machines that can read, explain, and evaluate contracts? Recent advances in machine learning have led to a fundamental breakthrough in machine language models, portending a profound shift in the ability of machines to process text. Such a shift has far-reaching consequences for diverse areas of law, which are predicated on, and justified by, the existence of information barriers. Our object here is to provide a general framework for evaluating the legal and policy implications of employing language models as "smart readers"-tools that read, analyze, and assess contracts, disclosures, and privacy policies.

Synthesizing state-of-the-art developments, …

Assessing Feature Representations For Instance-Based Cross-Domain Anomaly Detection In Cloud Services Univariate Time Series Data, Rahul Agrahari, Matthew Nicholson, Clare Conran, Haytham Assem, John D. Kelleher

Articles

In this paper, we compare and assess the efficacy of a number of time-series instance feature representations for anomaly detection. To assess whether there are statistically significant differences between different feature representations for anomaly detection in a time series, we calculate and compare confidence intervals on the average performance of different feature sets across a number of different model types and cross-domain time-series datasets. Our results indicate that the catch22 time-series feature set augmented with features based on rolling mean and variance performs best on average, and that the difference in performance between this feature set and the next best …

Assessing Feature Representations For Instance-Based Cross-Domain Anomaly Detection In Cloud Services Univariate Time Series Data, Rahul Agrahari, Matthew Nicholson, Clare Conran, Haythem Assem, John D. Kelleher

Articles

In this paper, we compare and assess the efficacy of a number of time-series instance feature representations for anomaly detection. To assess whether there are statistically significant differences between different feature representations for anomaly detection in a time series, we calculate and compare confidence intervals on the average performance of different feature sets across a number of different model types and cross-domain time-series datasets. Our results indicate that the catch22 time-series feature set augmented with features based on rolling mean and variance performs best on average, and that the difference in performance between this feature set and the next best …

Ultrasound 96 Probe Device Protocol For Cancer Cell Treatment, Aisling Field, Brijesh K. Tiwari, James F. Curtin, Julie R M Mondala, Janith Wanigasekara

Articles

Ultrasound is a sound wave with frequencies ranging between 20 kHz and 20 MHz. Ultrasound is able to temporarily and repeatedly open the BBB safely and enhance chemotherapeutic delivery without adverse effects. This novel technique in drug delivery benefits from the powerful ability of ultrasound to produce cavitation activity. Cavitation is the generation and activity of gas-filled bubbles in a medium exposed to ultrasound. As the pressure wave passes through the media, gas bubbles expand at low pressure and contract at high pressure. This leads to oscillation which produces a circulating fluid flow known as microstreaming around the bubble with …

Refactoring For Reuse: An Empirical Study, Eman Abdullah Alomar, Tianjia Wang, Vaibhavi Raut, Mohamed Wiem Mkaouer, Christian D. Newman, Ali Ouni

Articles

Refactoring is the de-facto practice to optimize software health. While several studies propose refactoring strategies to optimize software design through applying design patterns and removing design defects, little is known about how developers actually refactor their code to improve its reuse. Therefore, we extract, from 1,828 open source projects, a set of refactorings that were intended to improve the software reusability. We analyze the impact of reusability refactorings on the state-of-the-art reusability metrics, and we compare the distribution of reusability refactoring types, with the distribution of the remaining mainstream refactorings. Overall, we found that the distribution of refactoring types, applied …

Plasma Induced Reactive Oxygen Species-Dependent Cytotoxicity In Glioblastoma 3d Tumourspheres, Janith Wanigasekara, Carlos Barcia, Patrick J. Cullen, Brijesh Tiwari, James F. Curtin

Articles

The aim of this study was to determine the effects of a pin‐to‐plate cold atmospheric plasma (CAP) on U‐251 MG three‐dimensional (3D) glioblastoma spheroids under different conditions. 3D tumorspheres showed higher resistance to the CAP treatment compared to 2D monolayer cells. A single CAP treatment was able to induce cytotoxicity, while multiple CAP treatments augmented this effect. CAP was also able to induce cytotoxicity throughout the tumoursphere, and we identified that reactive oxygen species(ROS) plays a major role, while H2O2plays a partial role in CAP‐induced cytotoxicity in tumour-spheres. We conclude that ROS‐dependent cytotoxicity is induced uniformly throughout glioblastoma and epidermoid …

Active Packaging Film Based On Poly Lactide-Poly (Butylene Adipate-Co-Terephthalate) Blends Incorporated With Tannic Acid And Gallic Acid For The Prolonged Shelf Life Of Cherry Tomato, Shubham Sharma, Kalpani Perera, Dileswar Pradhan, Brendan Duffy, Amit Jaiswal, Swarna Jaiswal

Articles

The antimicrobial property is the key feature of active packaging. Biological macromolecules such as tannic and gallic acids are naturally found in plants such as tea, fruits, berries, and grapes. The incorporation of tannic acid (TA) and gallic acid (GA) in the biodegradable polymer blend Poly Lactide-Poly (Butylene Adipate-Co-Terephthalate) (PLA-PBAT) was used in this study to assess the potential of active packaging. TA and GA (10 wt%) composite films showed a 65%–66% increase in the UV barrier property. The tensile strength value increased after the incorporation of TA and GA (10 wt%), respectively. Overall, 1.67 and 2.2 log reductions in …

Analysis Of Human Gait Cycle With Body Equilibrium Based On Leg Orientation, Muhammad Asif, Muhammad Abdullah Tayyab, Muhammad Hammad Shahid, Usama Arif, Mohsin Islam Tiwana, Umar Shahbaz Khan, Waqar Shahid Qureshi

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Gait analysis identifies the posture during movement in order to provide the correct actions for a normal gait. A person's gait may differ from others and can be recognized by specific patterns. Healthy individuals exhibit normal gait patterns, while lower limb amputees exhibit abnormal gait patterns. To better understand the pitfalls of gait, it is imperative to develop systems capable of capturing the gait patterns of healthy individuals. The main objective of this research was to introduce a new concept in gait analysis by computing the static and dynamic equilibrium in a real-world environment. A relationship was also presented among …

Human Gait Recognition Subject To Different Covariate Factors In A Multi-View Environment, Asif Asif, Mohsin I. Tiwana, Umar S. Khan, Muhammad W. Ahmad, Waqar Shahid Qureshi, Javaid Iqbal Javaid Iqbal

Articles

Human gait recognition system identifies individuals based on their biometric traits. A human’s biometric features can be grouped into physiologic or behavioral traits. Biometric traits, such as the face [1], ears [2], iris [3], finger prints, passwords, and tokens, require highly accurate recognition and a well-controlled human interaction to be effective. In contrast, behavioral traits such as voice, signature, and gait do not require any human interaction and can be collected in a hidden and non-invasive mode with a camera system at a low resolution. In comparison with other physiological traits, one of the main advantages of gait analysis is …

Gender Equality In Higher Education And Research, Rodrigo Rosa, Sara Clavero

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No abstract provided.

Design And Development Of Magnetic Iron Core Gold Nanoparticle-Based Fluorescent Multiplex Assay To Detect Salmonella, Xinyi Zhao

Articles

Salmonella is a bacterial pathogen which is one of the leading causes of severe illnesses in humans. The current study involved the design and development of two methods, respectively using iron oxide nanoparticle (IONP) and iron core gold nanoparticle (ICGNP), conjugated with the Salmonella antibody and the fluorophore, 4-Methylumbelliferyl Caprylate (4-MUCAP), used as an indicator, for its selective and sensitive detection in contaminated food products. Twenty double-blind beverage samples, spiked with Salmonella enteritidis, Staphylococcus aureus, and Escherichia coli, were prepared in sterile Eppendorf® tubes at room temperature. The gold layer and spikes of ICGNPs increased the surface areas. The ratio …

Formulation, Characterisation And Evaluation Of The Antihypertensive Peptides, Isoleucine-Proline-Proline And Leucine-Lysine-Proline In Chitosan Nanoparticles Coated With Zein For Oral Drug Delivery, Minna Khalid Danish, John P. Gleeson, David J. Brayden, Hugh Byrne, Jesus Maria Frias, Sinead Ryan

Articles

Isoleucine-Proline-Proline (IPP) and Leucine-Lysine-Proline (LKP) are food-derived tripeptides whose antihypertensive functions have been demonstrated in hypertensive rat models. However, peptides display low oral bioavailability due to poor intestinal epithelial permeability and instability. IPP and LKP were formulated into nanoparticles (NP) using chitosan (CL113) via ionotropic gelation and then coated with zein. Following addition of zein, a high encapsulation efficiency (EE) (>80%) was obtained for the NP. In simulated gastric fluid (SGF), 20% cumulative release of the peptides was achieved after 2 h, whereas in simulated intestinal fluid (SIF), ~90% cumulative release was observed after 6 h. Higher colloidal stability …