Open Access. Powered by Scholars. Published by Universities.®
- Discipline
-
- Law (1029)
- Life Sciences (592)
- Medicine and Health Sciences (529)
- Physical Sciences and Mathematics (382)
- Engineering (205)
-
- Food Science (198)
- Physics (159)
- Biochemistry, Biophysics, and Structural Biology (141)
- Chemistry (109)
- Environmental Law (106)
- Biology (89)
- Social and Behavioral Sciences (82)
- Intellectual Property Law (71)
- Biochemistry (70)
- Law and Society (69)
- Family Law (67)
- Food Chemistry (66)
- Science and Technology Law (61)
- Pharmacology, Toxicology and Environmental Health (60)
- Food Microbiology (58)
- Medical Specialties (56)
- Public Health (56)
- Medical Sciences (55)
- Education (54)
- Electrical and Computer Engineering (51)
- Law and Gender (51)
- Biological and Chemical Physics (48)
- Food Processing (48)
- Health Law and Policy (48)
- Environmental Sciences (43)
- Institution
-
- Technological University Dublin (1606)
- University of Chicago Law School (263)
- University of Michigan Law School (205)
- University of Miami Law School (158)
- Southern Illinois University Carbondale (150)
-
- University of Washington School of Law (138)
- Rochester Institute of Technology (128)
- University of Minnesota Law School (111)
- University of Alabama School of Law (95)
- UIdaho Law (71)
- Yeshiva University, Cardozo School of Law (69)
- Utah State University (26)
- Mercer University School of Law (25)
- CentraCare Health (14)
- National Law School of India University (7)
- World Maritime University (7)
- Corewell Health (6)
- Munster Technological University (4)
- UAlaska System (4)
- University of Baltimore Law (4)
- WellBeing International (4)
- Liberty University (3)
- North Carolina Agricultural and Technical State University (3)
- Southwestern Oklahoma State University (1)
- University of South Carolina (1)
- Keyword
-
- Raman spectroscopy (53)
- Children (44)
- Ireland (38)
- Cytotoxicity (28)
- Patent law (24)
-
- Cancer (22)
- Obesity (21)
- Ultrasound (21)
- Climate change (20)
- Parents (20)
- Regulation (18)
- Nutrition (17)
- COVID-19 (16)
- Conservation (16)
- Research and development (16)
- Women (16)
- Animals (15)
- Law reform (15)
- Nanoparticles (15)
- Resilience (15)
- Technology (15)
- Antioxidant (14)
- Marriage (14)
- Same-sex marriage (14)
- United States Supreme Court (14)
- Cold plasma (13)
- Escherichia coli (13)
- Machine learning (13)
- Mice (13)
- Pregnancy (13)
- Publication Year
- File Type
Articles 1441 - 1470 of 3103
Full-Text Articles in Entire DC Network
Film: Deaf Characters, Miriam Nathan Lerner, Edna Edith Sayers
Film: Deaf Characters, Miriam Nathan Lerner, Edna Edith Sayers
Articles
This entry focuses on films made by American and foreign filmmakers who have little or no special interest in or knowledge about deaf people or Deaf communities. Casting hearing actors to portray deaf characters is unfortunately common. Because neither the filmmakers, the expected audiences, nor the actors know anything about d/Deaf people, inauthenticities are widespread. These problems are only slightly improved by casting a Deaf actor: Deaf actors can portray authentic use of a sign language but are often limited by the script, the director, and the editing process. Therefore, while the signing community commends the casting of Deaf actors, …
Getting ‘In’ And ‘Out Of Alignment’: Some Insights Into The Cultural Imagery Of Fitness From The Perspective Of Experienced Gym Adherents, Ross D. Neville, Catherine Gorman
Getting ‘In’ And ‘Out Of Alignment’: Some Insights Into The Cultural Imagery Of Fitness From The Perspective Of Experienced Gym Adherents, Ross D. Neville, Catherine Gorman
Articles
While the identification of risks associated with sedentary lifestyles provided a strong foundation for what we understand by ‘fitness’ today, research across the social sciences and humanities has been rather more ambivalent about the term. One important cause for concern here is the cultural proximity of ‘fitness’ to consumer culture by means of the ‘fitness industry’. It has been shown, for example, that the pursuit of fitness has become increasingly, if not exclusively, a matter of attending to the body as a marker of social status: something to be consumed for; something to be consumed by others. In this paper, …
Iron Acquisition In The Cystic Fibrosis Lung And Potential For Novel Therapeutic Strategies, Jean Tyrrell, Máire Callaghan
Iron Acquisition In The Cystic Fibrosis Lung And Potential For Novel Therapeutic Strategies, Jean Tyrrell, Máire Callaghan
Articles
Iron acquisition is vital to microbial survival and is implicated in the virulence of many of the pathogens that reside in the cystic fibrosis (CF) lung. The multifaceted nature of iron acquisition by both bacterial and fungal pathogens encompasses a range of conserved and species-specific mechanisms, including secretion of iron-binding siderophores, utilization of siderophores from other species, release of iron from host iron-binding proteins and haemoproteins, and ferrous iron uptake. Pathogens adapt and deploy specific systems depending on iron availability, bioavailability of the iron pool, stage of infection and presence of competing pathogens. Understanding the dynamics of pathogen iron acquisition …
Yo-Yo Intermittent Recovery Test Performance In Subelite Gaelic Football Players From Under Thirteen To Senior Age Groups, Mark Roe, Shane Malone
Yo-Yo Intermittent Recovery Test Performance In Subelite Gaelic Football Players From Under Thirteen To Senior Age Groups, Mark Roe, Shane Malone
Articles
Gaelic football is indigenous to Ireland and has similar locomotion profiles to soccer and Australian Football. Given the increasing attention on long-term player development, investigations into age-related variation in Yo-YoIR1 performance may provide useful information in talent identification, programme design, and player monitoring. Therefore, the aim of this study was to evaluate Yo-YoIR1 performance across Gaelic football age groups. Male participants (n = 355) were recruited from division one, Gaelic football teams. Participants were allocated to one of seven groups according to respective age groups from under 13 (U13), under 14, under 15 (U15), under 16 (U16), minor, under 21 …
Prospects For Subunit Vaccines: Technology Advances Resulting In Efficacious Antigens Requires Matching Advances In Early Clinical Trial Investment, Siobhan Mcclean
Prospects For Subunit Vaccines: Technology Advances Resulting In Efficacious Antigens Requires Matching Advances In Early Clinical Trial Investment, Siobhan Mcclean
Articles
With the continued march of antimicrobial resistance, a renewed impetus for better vaccines has been heralded. Identification of potent subunit vaccines has been greatly facilitated by recent developments in reverse vaccinology and proteomics strategies. There are a range of antimicrobial resistant bacterial pathogens that could be targeted by potent vaccine antigens identified within the coming years. However, cost is a significant hurdle in progressing lead antigen candidates to clinical trials. In order for novel vaccine technologies to realize their clinical potential, there is a requirement to improve investment and incentives to expedite the development of vaccines that are apparently efficacious …
Molecular Gastronomy, Roisin Burke, Herve This, Alan Kelly
Molecular Gastronomy, Roisin Burke, Herve This, Alan Kelly
Articles
Molecular gastronomy may be defined as the scientific discipline that explores the phenomena occurring during culinary transformations. In contrast with traditional approaches of food science and technology, which considered mostly the chemistry, physics, or biology of food ingredients and industrial transformations, the focus is on phenomena occurring during the preparation of dishes. Applications building on the principles of molecular gastronomy, such as ‘Molecular Cooking’ and ‘Note-by-Note cooking’ have emerged in recent years. Food scientists, culinary scientists, food engineers, and chefs are increasingly collaborating within these areas, whether in the kitchen or in industry. This article gives an overview of the …
Biofilm Growth Kinetics And Nutrient (N/P) Adsorption In An Urban Lake Using Reclaimed Water: A Quantitative Baseline For Ecological Health Assessment, Tianzhi Wang, Zhenci Wu, Yunkai Li, Mingchao Liang, Zhenhua Wang, Paul Hynds
Biofilm Growth Kinetics And Nutrient (N/P) Adsorption In An Urban Lake Using Reclaimed Water: A Quantitative Baseline For Ecological Health Assessment, Tianzhi Wang, Zhenci Wu, Yunkai Li, Mingchao Liang, Zhenhua Wang, Paul Hynds
Articles
Reclaimed wastewater reuse represents an effective method for partial resolution of increasing urban water shortages; however, reclaimed water may be characterized by significant contaminant loading, potentially affecting receiving ecosystem (and potentially human) health. The current study examined biofilm growth and nutrient adsorption in Olympic Lake (Beijing), the largest artificial urban lake in the world supplied exclusively by reclaimed wastewater. Findings indicate that solid particulate, extracellular polymeric substance (EPS) and metal oxide (Al, Fe, Mn) constituent masses adhere to a bacterial growth curve during biofilm formation and growth. Peak values were observed after ≈30 days, arrived at dynamic stability after ≈50days …
The Sin Of Turning Away From Reality: An Interview With Father Krzysztof Charamsa, David Paternotte, Mary Anne Case, Sarah Bracke
The Sin Of Turning Away From Reality: An Interview With Father Krzysztof Charamsa, David Paternotte, Mary Anne Case, Sarah Bracke
Articles
No abstract provided.
Antibacterial Properties Of F-Doped Zno Visible Light Photocatalyst, Joanna Podporska-Carroll, Adam Myles, Brid Quilty, Declan Mccormack, Rachel Fagan, Steven Hinder, Dionysios Dionysiou, Suresh Pillai
Antibacterial Properties Of F-Doped Zno Visible Light Photocatalyst, Joanna Podporska-Carroll, Adam Myles, Brid Quilty, Declan Mccormack, Rachel Fagan, Steven Hinder, Dionysios Dionysiou, Suresh Pillai
Articles
Nanocrystalline ZnO photocatalysts were prepared by a sol–gel method and modified with fluorine to improve their photocatalytic anti-bacterial activity in visible light. Pathogenic bacteria such as Escherichia coli (Gram-negative) and Staphylococcus aureus (Gram-positive) were employed to evaluate the antimicrobial properties of synthesized materials. The interaction with biological systems was assessed by analysis of the antibacterial properties of bacteria suspended in 2% (w/w) powder solutions. The F-doping was found to be effective against S. aureus (99.99% antibacterial activity) and E. coli (99.87% antibacterial activity) when irradiated with visible light. Production of reactive oxygen species is one of the major factors that …
Utilising A Loop Structure To Allow A Microfiber Coupler With Larger Taper Diameters To Be Used For Sensing, Fangfang Wei, Gerald Farrell, Qiang Wu, Yuliya Semenova
Utilising A Loop Structure To Allow A Microfiber Coupler With Larger Taper Diameters To Be Used For Sensing, Fangfang Wei, Gerald Farrell, Qiang Wu, Yuliya Semenova
Articles
This paper examines a technique that utilizes a Sagnac loop with a microfiber coupler (MFC) as a coupler which allows the MFC to operate effectively as a sensor but with larger than normal tapered fiber diameters. The proposed structure is found to be suitable for temperature and refractive index (RI) sensing. It is shown that a variation in the surrounding of the MFC RI results in a shift of the output spectrum, while a temperature variation leads to changes in the intensity of the interference dips. A decrease in the waist diameter of the MFC results in an increase in …
Predicting Asthma Exacerbations Employing Remotely Monitored Adherence, Isabelle Killane, Imran Sulaiman, Elaine Mac Hale, Aoife Breathnach, Terrence Taylor, Martin Holmes, Richard B Reilly, Richard W Costello
Predicting Asthma Exacerbations Employing Remotely Monitored Adherence, Isabelle Killane, Imran Sulaiman, Elaine Mac Hale, Aoife Breathnach, Terrence Taylor, Martin Holmes, Richard B Reilly, Richard W Costello
Articles
This Letter investigated the efficacy of a decision-support system, designed for respiratory medicine, at predicting asthma exacerbations in a multi-site longitudinal randomised control trial. Adherence to inhaler medication was acquired over 3 months from patients with asthma employing a dose counter and a remote monitoring adherence device which recorded participant's inhaler use: n = 184 (23,656 audio files), 61% women, age (mean ± sd) 49.3 ± 16.4. Data on occurrence of exacerbations was collected at three clinical visits, 1 month apart. The relative risk of an asthma exacerbation for those with good and poor adherence was examined employing a univariate …
Biofilm Microbial Community Structure In An Urban Lake Utilizing Reclaimed Water, Tianzhi Wang, Yunkai Li, Tingwu Xu, Naiyang Wu, Mingchao Liang, Paul Hynds
Biofilm Microbial Community Structure In An Urban Lake Utilizing Reclaimed Water, Tianzhi Wang, Yunkai Li, Tingwu Xu, Naiyang Wu, Mingchao Liang, Paul Hynds
Articles
Analyses of biofilm community structure may potentially be employed for aquatic ecosystem health assessment, however, to date, biofilm diversity within urban lakes using reclaimed water has not been examined. Accordingly, the microbial community diversity and structure of biofilms from the surface of multiple matrices with varying roughness (0.1, 1.0 and 10.0 μm) were characterized using a suite of molecular techniques including scanning electron microscopy, genetic fingerprinting and phospholipid-derived fatty acid analyses. Samples were largely comprised of inorganic particles, algae and numerous bacterial species; 12 phospholipid-derived fatty acid (PLFA) types were identified, significantly less than typically associated with sewage. Both growth …
Water Law Reform In The Face Of Climate Change: Learning From Drought In Australia And The Western United States, Barbara Cosens
Water Law Reform In The Face Of Climate Change: Learning From Drought In Australia And The Western United States, Barbara Cosens
Articles
Western societies have developed three approaches to governance of common pool resources such as water: 1) The division of the resource into private property; (2) government regulation; and 3) local self-organization. This article asserts that all three are needed in varying combinations to rise to the challenge presented by the impact of climate change on water supply and demand. Drought presents a preview of potential future climate scenarios and Australia and the western United States are both responding to its harshness through innovation in water governance. These experiments present an opportunity to compare the approaches of Australia and the western …
Adaptive Governance Of Water Resources Shared With Indigenous Peoples: The Role Of Law, Barbara Cosens
Adaptive Governance Of Water Resources Shared With Indigenous Peoples: The Role Of Law, Barbara Cosens
Articles
Adaptive governance is an emergent phenomenon resulting from the interaction of locally driven collaborative efforts with a hierarchy of governmental regulation and management and is thought to be capable of navigating social-ecological change as society responds to the effects of climate change. The assertion of Native American water rights on highly developed water systems in North America has triggered governance innovations that resemble certain aspects of adaptive governance, and have emerged to accommodate the need for Indigenous water development and restoration of cultural and ecological resources. Similar innovations are observed in the assertion of Indigenous voices in Australia. This presents …
Avoiding Decline: Fostering Resilience And Sustainability In Midsize Cities, Barbara Cosens
Avoiding Decline: Fostering Resilience And Sustainability In Midsize Cities, Barbara Cosens
Articles
Eighty-five percent of United States citizens live in urban areas. However, research surrounding the resilience and sustainability of complex urban systems focuses largely on coastal megacities (>1 million people). Midsize cities differ from their larger counterparts due to tight urban-rural feedbacks with their immediate natural environments that result from heavy reliance and close management of local ecosystem services. They also may be less path-dependent than larger cities due to shorter average connection length among system components, contributing to higher responsiveness among social, infrastructural, and ecological feedbacks. These distinct midsize city features call for a framework that organizes information and …
Towards 3d In Vitro Models For The Study Of Cardiovascular Tissues And Disease, Claire M. Brougham, Alan J. Ryan, Carolina D. Garciarena, Steve W. Kerrigan, Fergal J. O'Brien
Towards 3d In Vitro Models For The Study Of Cardiovascular Tissues And Disease, Claire M. Brougham, Alan J. Ryan, Carolina D. Garciarena, Steve W. Kerrigan, Fergal J. O'Brien
Articles
The field of tissue engineering is developing biomimetic biomaterial scaffolds which are showing increasing therapeutic potential for the repair of cardiovascular tissues. However, a major opportunity exists to use them as 3D in vitro models for the study of cardiovascular tissues and disease in addition to drug development and testing. These in vitro models can span the gap between 2D culture and in vivo testing thus reducing cost, time and the ethical burden of current approaches. This review outlines the progress to date and requirements for the development of ideal in vitro 3D models for blood vessels, heart valves and …
Enhancing Conservation Options: An Argument For Statutory Recognition Of Options To Purchase Conservation Easements (Opces), Federico Cheever, Jessica Owley
Enhancing Conservation Options: An Argument For Statutory Recognition Of Options To Purchase Conservation Easements (Opces), Federico Cheever, Jessica Owley
Articles
Land conservation transactions have been the most active component of the conservation movement in the United States for the past three decades. Conservation organizations have acquired property rights-mostly conservation easements-to protect roughly 40 million acres of land nationwide. However, climate change threatens this vast edifice. Climate change means that the resources that land conservation transactions were intended to protect may not persist on the land protected. Options to purchase conservation easements ("OPCEs") have long played a modest but important role in conservation law practice. In the world climate change is creating, with its substantial uncertainties and shifting windows of opportunity, …
The Grass Is Not Always Greener: Congressional Dysfunction, Executive Action, And Climate Change In Comparative Perspective, Hari Osofsky, Jacqueline Peel
The Grass Is Not Always Greener: Congressional Dysfunction, Executive Action, And Climate Change In Comparative Perspective, Hari Osofsky, Jacqueline Peel
Articles
Partisan climate change politics, paired with a legislative branch that is often deeply divided between two parties, has led to congressional gridlock in the United States. Numerous efforts at passing comprehensive climate change legislation have failed, and little prospect exists for such legislation in the foreseeable future. As a result, executive action under existing federal environmental statutes--often in interaction with litigation--has become the primary mechanism for national-level regulation of greenhouse gas emissions from motor vehicles and power plants. Although many observers critique this state of affairs and wish for a legislature more able to act. this essay argues that more …
Arctic Energy Cooperation, Hari M. Osofsky, Jessica Shadian, Sara L. Fechtelkotter
Arctic Energy Cooperation, Hari M. Osofsky, Jessica Shadian, Sara L. Fechtelkotter
Articles
The Arctic – with almost a third of the world’s remaining natural gas and thirteen percent of its oil – is one of the globe’s last frontiers for competition over unexplored natural resources. The rapid pace of Arctic melting due to climate change has created opportunities to extract the region’s previously inaccessible offshore oil and gas. The 2015 controversy over the Obama Administration’s approval of Shell Oil’s drilling in the Chukchi Sea followed by the company’s decision to pull out highlighted the need for clear and effective regulation of Arctic drilling. Offshore oil spills are difficult to prevent and clean …
Energy Partisanship, Hari M. Osofsky, Jacqueline Peel
Energy Partisanship, Hari M. Osofsky, Jacqueline Peel
Articles
Whether the topic is the Paris Agreement on climate change, greenhouse gas emissions from power plants, the Keystone XL pipeline, hydraulic fracturing, offshore drilling, or renewable energy, much of the U.S. policy dialogue about energy and climate change is deeply partisan. Republicans and Democrats debate individual issues in vitriolic sound bites that indicate minimal common ground. For example, officials favoring robust action on climate change are charged with engaging in a “War on Coal.” Those opposed are labeled “members of the Flat Earth Society.” Set against these dysfunctional climate and energy politics, how can progress be made? For people who …
Self-Powered Microfluidic Device For Rapid Assay Of Antiplatelet Drugs, Bincy Jose, Peter Mccluskey, Niamh Gilmartin, Martin Somers, Dermot Kenny, Antonio J. Ricco, Nigel Kent, Lourdes Basabe-Desmonts
Self-Powered Microfluidic Device For Rapid Assay Of Antiplatelet Drugs, Bincy Jose, Peter Mccluskey, Niamh Gilmartin, Martin Somers, Dermot Kenny, Antonio J. Ricco, Nigel Kent, Lourdes Basabe-Desmonts
Articles
We report the development of a microfluidic device for the rapid assay in whole blood of platelet-protein interactions indicative of the efficacy of antiplatelet drugs—e.g., aspirin and Plavix, two of the world’s most widely used drugs—in cardiovascular patients. Because platelet adhesion to surface-confined protein matrices is modulated by fluid shear rates at the blood/protein interface, and because such binding is a better indicator of platelet function than platelet self-aggregation, we designed, fabricated, and characterized the performance of a family of disposable, self-powered microfluidic chips with well-defined flow and interfacial shear rates suitable for small blood volumes (≤ 200 µL). We …
Physical And Oxidative Stability Of Functional Olive Oil-In-Water Emulsions Formulated Using Olive Mill Wastewater And Whey Proteins, Nicola Caporaso, Alessandro Genovese, Roisin Burke, Catherine Barry-Ryan, Raffaele Sacchi
Physical And Oxidative Stability Of Functional Olive Oil-In-Water Emulsions Formulated Using Olive Mill Wastewater And Whey Proteins, Nicola Caporaso, Alessandro Genovese, Roisin Burke, Catherine Barry-Ryan, Raffaele Sacchi
Articles
The present paper reports on the use of phenolic extracts from olive mill wastewater (OMW) in model olive oil-in-water (O/W) emulsions to study their effect on their physical and chemical stability. Spray-dried OMW polyphenols were added to a model 20% olive O/W emulsion stabilized with whey protein isolate (WPI) and xanthan gum, in phosphate buffer solution at pH 7. The emulsions were characterised under accelerated storage conditions (40 °C) up to 30 days. Physical stability was evaluated by analysing the creaming rate, mean particle size distribution and mean droplet size, viscosity and rheological properties, while chemical stability was assessed through …
Regional Energy Governance And U.S. Carbon Emissions, Hari Osofsky, Hannah Jacobs Wiseman
Regional Energy Governance And U.S. Carbon Emissions, Hari Osofsky, Hannah Jacobs Wiseman
Articles
The U.S. Environmental Protection Agency’s final rule that limits carbon dioxide emissions from existing power plants — the Clean Power Plan — is an environmental regulation that powerfully influences energy law and forms a key part of the U.S. plan to meet its voluntary international commitments under the December 2015 Paris Agreement on climate change. Even if portions of the Plan are ultimately struck down, almost any viable pathway to lower carbon emissions will require greater integration of these two areas of law to address the large percentage of U.S. emissions from the energy sector. This integration produces both challenges …
Nonmarriage, June Carbone, Naomi Cahn
Nonmarriage, June Carbone, Naomi Cahn
Articles
Now that the Supreme Court has reshaped the laws of marriage, attention is shifting to nonmarriage. The law no longer treats intimate couples who do not marry as either deviant or deprived. Yet, rather than regulate nonmarriage in a systematic way, the law applies two inconsistent doctrines to govern these relationships. This Article is the first to explore the fundamental contradiction in the legal approach to unmarried partners. While the laws governing financial obligations between unmarried couples are moving toward a deregulatory model that radically differs from the status-based regulation of marriage, the laws of custody and support insist on …
Technology, Gender And Fashion, Jeanne L. Schroeder
Consideration Of Genetic Connections In Child Custody Disputes Between Same-Sex Parents: Fair Or Foul?, Jessica Feinberg
Consideration Of Genetic Connections In Child Custody Disputes Between Same-Sex Parents: Fair Or Foul?, Jessica Feinberg
Articles
Historically, in child custody disputes involving same-sex couples who conceived their children through assisted reproductive technology, the law only recognized the relationship between the child and the member of the same-sex couple who was the child’s genetic parent. Consequently, non-genetic parents in these situations were frequently denied standing to seek custody or visitation following the dissolution of their relationship with the child’s genetic parent. Due to recent legal advancements, however, it is becoming far more common for both members of a same-sex couple to be legally recognized as the parents of a child conceived through assisted reproductive technology. Unfortunately, despite …
Gradual Marriage, Jessica Feinberg
Gradual Marriage, Jessica Feinberg
Articles
The time has come to reform the law governing marriage. In determining the rights and obligations between spouses arising from marriage, current law does not adequately account for the way in which spousal behaviors and expectations change over the course of a marriage. With regard to intact marriages, under the existing legal framework, the spousal rights and obligations enjoyed by couples in intact marriages arise all at once—at the moment a couple is granted a marriage license—and do not change as the years of marriage pass or as children are born to the marriage. In terms of dissolving marriages, with …
Enhanced Cognition And Hypoglutamatergic Signaling In A Growth Hormone Receptor Knockout Mouse Model Of Successful Aging., Kevin N Hascup, Mary K Lynn, Patrick J Fitzgerald, Shari Randall, John J Kopchick, Heather A Boger, Andrzej Bartke, Erin R Hascup
Enhanced Cognition And Hypoglutamatergic Signaling In A Growth Hormone Receptor Knockout Mouse Model Of Successful Aging., Kevin N Hascup, Mary K Lynn, Patrick J Fitzgerald, Shari Randall, John J Kopchick, Heather A Boger, Andrzej Bartke, Erin R Hascup
Articles
Growth hormone receptor knockout (GHR-KO) mice are long lived with improved health span, making this an excellent model system for understanding biochemical mechanisms important to cognitive reserve. The purpose of the present study was to elucidate differences in cognition and glutamatergic dynamics between aged (20- to 24-month-old) GHR-KO and littermate controls. Glutamate plays a critical role in hippocampal learning and memory and is implicated in several neurodegenerative disorders, including Alzheimer's disease. Spatial learning and memory were assessed using the Morris water maze (MWM), whereas independent dentate gyrus (DG), CA3, and CA1 basal glutamate, release, and uptake measurements were conducted in …
Linocin And Ompw Are Involved In Attachment Of The Cystic Fibrosis-Associated Pathogen Burkholderia Cepacia Complex To Lung Epithelial Cells And Protect Mice Against Infection, Siobhan Mcclean, Marc Healy, Cassandra Collins, Stephen Carberry, Luke O'Shaughnessy, Ruth Dennehy, Aine Adams Aine Adams, Helen Kennelly, Jennifer Corbett, Fiona Carty, Laura Ann Cahill, Máire Callaghan, Karen English, Bernard P. Mahon, Sean Doyle, Minu Shinoy
Linocin And Ompw Are Involved In Attachment Of The Cystic Fibrosis-Associated Pathogen Burkholderia Cepacia Complex To Lung Epithelial Cells And Protect Mice Against Infection, Siobhan Mcclean, Marc Healy, Cassandra Collins, Stephen Carberry, Luke O'Shaughnessy, Ruth Dennehy, Aine Adams Aine Adams, Helen Kennelly, Jennifer Corbett, Fiona Carty, Laura Ann Cahill, Máire Callaghan, Karen English, Bernard P. Mahon, Sean Doyle, Minu Shinoy
Articles
Burkholderia cepacia complex (Bcc) causes chronic opportunistic lung infections in people with cystic fibrosis (CF) resulting in a gradual lung function decline and, ultimately, patient death. Bcc is a complex of eighteen species and is rarely eradicated once a patient is colonised, therefore vaccination may represent a better therapeutic option. We developed a new proteomics approach to identify bacterial proteins that are involved in attachment of Bcc to lung epithelial cells. Fourteen proteins were reproducibly identified by 2-DE from four Bcc strains, representative of two Bcc species: B. cenocepacia, the most virulent and B. multivorans, the most frequently acquired. Seven …
Resolving The Policy Paradox: The Case Of Biofuel Production In Ireland, Alan Gilmer, Mark J. Mcgarrity, Vivienne Byers
Resolving The Policy Paradox: The Case Of Biofuel Production In Ireland, Alan Gilmer, Mark J. Mcgarrity, Vivienne Byers
Articles
Purpose – The purpose of this paper is to determine the status of policy design and policy implementation in the biofuel sector in Ireland. The focus of the work addresses the overarching operational context of the biofuel sector in Ireland and the role of different actors in shaping and resolving inconsistencies in policy outlook and practice. Design/methodology/approach – This study used a qualitative research approach involving a series of semi-structured interviews with members of the relevant sub-groups concerned. This study sought to address two questions – whether current or proposed policy is likely to affect consumption of indigenous biofuel feedstocks …