Digital Commons Network^™

Comparison Of Semi-Automated And Manual Measurements Of Carotid Intima-Media Thickening, Oscar Mac Ananey, G Mellotte, V Maher

Articles

Carotid intima-media thickening (CIMT) is a marker of both arteriosclerotic and atherosclerotic risks. Technological advances have semiautomated CIMT image acquisition and quantification. Studies comparing manual and automated methods have yielded conflicting results possibly due to plaque inclusion in measurements. Low atherosclerotic risk subjects (n = 126) were recruited to minimise the effect of focal atherosclerotic lesions on CIMT variability. CIMT was assessed by high-resolution B-mode ultrasound (Philips HDX7E, Phillips, UK) images of the common carotid artery using both manual and semiautomated methods (QLAB, Phillips, UK). Intraclass correlation coefficient (ICC) and the mean differences of paired measurements (Bland-Altman method) were used …

Proteomic Profiling Of Burkholderia Cenocepacia Clonal Isolates With Different Virulence Potential Retrieved From A Cystic Fibrosis Patient During Chronic Lung Infection., Siobhan Mcclean, Máire Callaghan, Jean Tyrrell, Isabelle Sa Correia

Articles

Respiratory infections with Burkholderia cepacia complex (Bcc) bacteria in cystic fibrosis (CF) are associated with a worse prognosis and increased risk of death. In this work, we assessed the virulence potential of three B. cenocepacia clonal isolates obtained from a CF patient between the onset of infection (isolate IST439) and before death with cepacia syndrome 3.5 years later (isolate IST4113 followed by IST4134), based on their ability to invade epithelial cells and compromise epithelial monolayer integrity. The two clonal isolates retrieved during late-stage disease were significantly more virulent than IST439. Proteomic profiling by 2-D DIGE of the last isolate recovered …

Benefits Of Video Presentations In Product Design, Alex Lobos

Articles

Product Design uses a human-centered process to develop solutions that solve unmet user needs. Because of the sequential nature of this activity, final designs are often presented in printed process books or digital slideshows, which visually communicate the development of the solution from start to finish rather than focusing just on the final result. Storytelling is a key element to consider when creating these process books in order to communicate the design solution as well as where it came from. An alternative to these presentations is the use of short videos, which offer the advantage of communicating the design process …

Understanding The Attitude-Behavior Gap For Renewable Energy Systems Using Behavioral Reasoning Theory, Marius Claudy, Mark Peterson, Aidan O'Driscoll

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Consumer adoption of renewable energies is an important step towards less carbon-intensive and more sustainable energy systems. But despite growing ecological awareness and articulated preferences for green products, renewable energies face slow rates of diffusion in consumer markets. This has been hard to explain given consumers’ favorability to the concept of products that lower one’s impact on the natural environment. This study uses data from 254 homeowners in Ireland to investigate the psychological process of adopting a renewable energy system – solar energy panels. Applying Behavioral Reasoning Theory (BRT), this research examines a proposed model in which reasons both for …

Resilience To Stress And Disturbance, And Resistance To Bromus Tectorum L. Invasion In Cold Desert Shrublands Of Western North America, Jeanne C. Chambers, Bethany A. Bradley, Cynthia S. Brown, Carla D'Antonio, Matthew J. Germino, James B. Grace, Stuart P. Hardegree, Richard F. Miller, David A. Pyke

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Alien grass invasions in arid and semi-arid ecosystems are resulting in grass–fire cycles and ecosystem-level transformations that severely diminish ecosystem services. Our capacity to address the rapid and complex changes occurring in these ecosystems can be enhanced by developing an understanding of the environmental factors and ecosystem attributes that determine resilience of native ecosystems to stress and disturbance, and resistance to invasion. Cold desert shrublands occur over strong environmental gradients and exhibit significant differences in resilience and resistance. They provide an excellent opportunity to increase our understanding of these concepts. Herein, we examine a series of linked questions about (a) …

The Legacy Of Broken Faith, Eamon Maher

Articles

One of the advantages of a crisis within any human institution is that it generates fracture, encourages re-evaluation, self-criticism, and, occasionally, anger. In April2011, a conference was organised in Milltown Institute around the theme of Broken Faith: &-visioning the Church in Ireland.

Patent Invalidity Versus Noninfringement, Roger Ford

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No abstract provided.

Is It Time To Abolish The Federal Circuit's Exclusive Jurisdiction In Patent Cases?, Diane P. Wood

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No abstract provided.

A Comparative Cytotoxic Evaluation Of Acrylamide And Diacetone Acrylamide To Investigate Their Suitability For Holographic Photopolymer Formulations, Dervil Cody, Alan Casey, Izabela Naydenova, Emilia Mihaylova

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The comparative cytotoxic evaluation of two monomers Diacetone Acrylamide (DA) and Acrylamide (AA), used in holographic photopolymer formulations, is reported. Two normal cell lines were used: BEAS-2B and HaCaT. Cellular viability was assessed using the MTT assay for three different exposure times. A difference of two orders of magnitude is observed in the Lethal Dose (LD50) concentrations of the two monomers. Diacetone Acrylamide exhibits a significantly lower toxicity profile in comparison to Acrylamide at all exposure times. This result justifies the replacement of Acrylamide with Diacetone Acrylamide in the photopolymer formulation, with the view to reducing occupational hazard risks for …

Maximising Value Of Electrical Networks For Wave Energy Converter Arrays, Fergus Sharkey, Elva Bannon, Michael Conlon, Kevin Gaughan

Articles

Currently there are the beginnings of a commercial wave energy industry and the ultimate ambition will be to deploy Wave Energy Converters (WECs) in arrays, or wave farms, in a similar fashion to offshore wind. These arrays will require electrical networks to collect and export the generated electrical power to shore and onto the electrical grid. For large scale wind farms the inter-array and export electrical networks can represent more than 20% of the project’s capital expenditure. Submarine power cables account for a large proportion of this cost. The same is expected to be the same for WEC arrays.

This …

Single-Mode Tunable Laser Emission In The Single-Exciton Regime From Colloidal Nanocrystals, Christos Grivas, Chunyong Li, Peristera Andreakou, Pengfei Wang, Ming Ding, Gilberto Brambilla, Liberato Manna, Pavlos Lagoudakis

Articles

Whispering-gallery-mode resonators have been extensively used in conjunction with different materials for the development of a variety of photonic devices. Among the latter, hybrid structures, consisting of dielectric microspheres and colloidal core/shell semiconductor nanocrystals as gain media, have attracted interest for the development of microlasers and studies of cavity quantum electrodynamic effects. Here we demonstrate single-exciton, single-mode, spectrally tuned lasing from ensembles of optical antenna-designed, colloidal core/shell CdSe/CdS quantum rods deposited on silica microspheres. We obtain singleexciton emission by capitalizing on the band structure of the specific core/shell architecture that strongly localizes holes in the core, and the two-dimensional quantum …

Mock Trials And Real Justices And Judges, Richard A. Posner

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No abstract provided.

The Mink Framework: Towards Measuring Individual Knowledge, Mohamed Ragab, Amr Arisha

Articles

Knowledge is the currency of the current economy and a vital resource for sustaining organisational performance in today’s knowledge-based intensively competitive business environment. To avoid the detrimental consequences of knowledge loss, managers are urged to identify where knowledge stocks exist and how knowledge flows within their organisations by identifying knowledge holders among their employees. Although some studies have attempted to use different methods to measure knowledge at the organisational level, very few have addressed the individual knowledge holder. Moving from a critical literature review of the existing knowledge measurement approaches, this paper proposes a novel framework that enables organisations to …

Mutational Analysis Of Sse1 (Hsp110) Suggests An Integral Role For This Chaperone In Yeast Prion Propagation In Vivo, Ciara Moran, Gemma Kinsella, Zai-Rong Zhang, Sarah Perrett, Gary Jones

Articles

ABSTRACT The yeast Hsp110 chaperone Sse1 is a conserved protein that is a noncanonical member of the Hsp70 protein superfamily. Sse1 influences the cellular response to heat stress and has also been implicated in playing a role in the propagation of prions in yeast. Sse1 can seemingly exert its effects in vivo through direct or indirect actions by influencing the nucleotide exchange activity of canonical cytosolic Hsp70s. Using a genetic screen based on the inability to propagate the yeast [PSI+] prion, we have identified 13 new Sse1 mutants that are predicted to alter chaperone function through a variety of different …

Kinetics Of Tomato Peroxidase Inactivation By Atmospheric Pressure Cold Plasma Based On Dielectric Barrier Discharge, Patrick J. Cullen, Shashi Pankaj, N. Misra

Articles

Atmospheric pressure cold plasma technology is an emerging nonthermal food technology for microbiological decontamination of food and bio-materials. This study demonstrates the applicability of in-package cold plasma technology as a novel means to inactivation of enzymes. The kinetics of inactivation of tomato peroxidase as a model enzyme was studied at 30, 40 and 50kV, for up to 5’ of atmospheric air dielectric barrier discharge plasma treatments. The enzyme activity was found to decrease with both treatment time and voltage, the former variable exhibiting a more pronounced effect. Kinetic models viz. first-order, Weibull and logistic models were fitted to the experimentally …

Silver Linings: Reimagining The Role Of Adr Education In The Wake Of The Great Recession, Lela P. Love, Brian Farkas

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No abstract provided.

Rethinking The Digital Media Library For Rit's The Wallace Center, April Younglove

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In 2012, the Digital Preservation Team at Rochester Institute of Technology's The Wallace Center undertook an assessment of its Institutional Repository, the Digital Media Library. The Digital Preservation Team looked at the repository's current performance and requirements for ensuring its future success, and then examined four different philosophical approaches to configuring an IR that are in use by research institutions today: All-in-one, Archival, Researcher-centric and Subject. The team also compared open source vs. in-house repository providers and services including DSpace, Digital Commons, IR+, and Discovery Garden. A decision was made to move from the open source software DSpace to the …

Towards Engaged Scholarship, Jessica Owley, John R. Nolon, Keith Hirokawa, Sean Nolon

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No abstract provided.

Using A Human Rights Approach In Immigration Advocacy: An Introduction, Rebecca Sharpless, Robert Pauw, Judith L. Wood

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No abstract provided.

Indoor Positioning For Smartphones Using Asynchronous Ultrasound Trilateration, Viacheslav Filonenko, Charlie Cullen, James Carswell

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Modern smartphones are a great platform for Location Based Services (LBS). While outdoor LBS for smartphones has proven to be very successful, indoor LBS for smartphones has not yet fully developed due to the lack of an accurate positioning technology. In this paper we present an accurate indoor positioning approach for commercial off-the-shelf (COTS) smartphones that uses the innate ability of mobile phones to produce ultrasound, combined with Time-Difference-of-Arrival (TDOA) asynchronous trilateration. We evaluate our indoor positioning approach by describing its strengths and weaknesses, and determine its absolute accuracy. This is accomplished through a range of experiments that involve variables …

Towards A Structured Approach To Reading Historic Cookbooks, Máirtín Mac Con Iomaire

Articles

This article discusses the methodology Barbara Ketchum Wheaton uses in her Reading historic Cookbook Seminars in Harvard and elsewhere and discusses from a participants perspective the strenghts of using this methodology to unlock hidden secrets of historic cookbooks.

Dual Orientation Of The Outer Membrane Lipoprotein P6 Of Nontypeable Haemophilus Influenzae, Lea V. Michel, Joy Snyder, Rachel Schmidt, Jennnifer Milillo, Kyle Grimaldi, Breanna Kalmeta, M. Nadeem Khan, Sharad Sharma, Leslie Kate Wright, Michael E. Pichichero

Articles

The majority of outer membrane (OM) lipoproteins in Gram-negative bacteria are tethered to the membrane via an attached lipid moiety and oriented facing in toward the periplasmic space; a few lipoproteins have been shown to be surface exposed. The outer membrane lipoprotein P6 from the Gram-negative pathogenic bacterium nontypeable Haemophilus influenzae (NTHi) is surface exposed and a leading vaccine candidate for prevention of NTHi infections. However, we recently found that P6 is not a transmembrane protein as previously thought (L. V. Michel, B. Kalmeta, M. McCreary, J. Snyder, P. Craig, M. E. Pichichero, Vaccine 29:1624–1627, 2011). Here we pursued studies …

Developing A Collaborative Virtual Learning Environment Between Students In Cross Disciplines In The Built Environment., Fiacra Mcdonnell, Ruairi Hayden

Articles

Integrated Project Delivery is a rapidly developing approach to Design and Construction.This approach uses business structures, new technologies, and newly developing practices to collaboratively utilise the talents and contributions of all participants in the Design and Construction process.This project replicated this approach by creating a collaborative project between the School of Construction and the School of Real Estate and Construction Economics. The term “collaborative learning” refers to a method of delivery in which students at various performance levels work together in small groups towards a common goal. The students were responsible for one another’s learning as well as their own. …

We The People, They The People, And The Puzzle Of Democratic Constitutionalism, David A. Strauss

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No abstract provided.

Novel Dielectric Loaded Plasmonic Waveguide For Tight-Confined Hybrid Plasmon Mode, Youqiao Ma, Gerald Farrell, Yuliya Semenova, Hauping Chan, Hongzhou Zhang, Qiang Wu

Articles

In this paper a novel metal-dielectric waveguide structure is proposed to support hybrid long range surface plasmon polaritons (LRSPPs) with a highly confined mode field. The simulation results showed that our proposed structure has better mode confinement and propagation length compared to that of conventional dielectric-loaded surface plasmon polaritons (DLSPPs) waveguides. This structure offers greater flexibility for the design of SPPs waveguides by altering the trade-off between mode confinement and propagation length. The proposed structure has significant potential for application in highly integrated photonic circuits.

Isolation And Partial Characterization Of Bioactive Fucoxanthin From Himanthalia Elongata Brown Seaweed: A Tlc-Based Approach, Gaurav Rajauria, Nissreen Abu-Ghannam

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Seaweeds are important sources of carotenoids, and numerous studies have shown the beneficial effects of these pigments on human health. In the present study, Himanthalia elongata brown seaweed was extracted with a mixture of low polarity solvents, and the crude extract was separated using analytical thin-layer chromatography (TLC).The separated compounds were tested for their potential antioxidant capacity and antimicrobial activity against Listeria monocytogenes bacteria using TLC bioautography approach. For bio-autography, the coloured band on TLC chromatogram was visualized after spraying with DPPH and triphenyltetrazolium chloride reagents which screen antioxidant and antimicrobial compounds, respectively, and only one active compound was screened …

Using Pcr To Target Misconceptions About Gene Expression, Leslie Kate Wright, Dina L. Newman

Articles

We present a PCR-based laboratory exercise that can be used with first- or second-year biology students to help overcome common misconceptions about gene expression. Biology students typically do not have a clear understanding of the difference between genes (DNA) and gene expression (mRNA/protein) and often believe that genes exist in an organism or cell only when they are expressed. This laboratory exercise allows students to carry out a PCR-based experiment designed to challenge their misunderstanding of the difference between genes and gene expression. Students first transform E. coli with an inducible GFP gene containing plasmid and observe induced and un-induced …

Using Pcr To Target Misconceptions About Gene Expression, Leslie Kate Wright, Dina L. Newman

Articles

We present a PCR-based laboratory exercise that can be used with first- or second-year biology students to help overcome common misconceptions about gene expression. Biology students typically do not have a clear understanding of the difference between genes (DNA) and gene expression (mRNA/protein) and often believe that genes exist in an organism or cell only when they are expressed. This laboratory exercise allows students to carry out a PCR-based experiment designed to challenge their misunderstanding of the difference between genes and gene expression. Students first transform E. coli with an inducible GFP gene containing plasmid and observe induced and un-induced …

Rationalizing Creativity—Rationalizing Public Service: Is Scheduling Management Fit For The Digital Era?, Ann-Marie Murray

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In public broadcast organizations across Europe, scheduling has been transformed from a marginal, administrative activity to a highly strategic management tool (Hellman, 1999; Hujanen, 2002; Meier, 2003;Ytreberg, 2000) Ellis (2000)described it as “the locus of power in television,” organizing production and managing budgets (p. 26). The role of scheduling in public broadcast organizations today reflects the demands of increasing competition and political pressure for efficiency and accountability. However, new challenges have emerged in the transition from public service broadcasting to public service media (PSM). PSM providers must redefine their mission for the digital era and find …

Toward A Positive Theory Of Privacy Law, Lior Strahilevitz

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No abstract provided.