Digital Commons Network^™

Free Energies And Minimal States For Scalar Linear Viscoelasticity, Giovambattista Amendola, Mauro Fabrizio, John Murrough Golden

Articles

The concept of a minimal state was introduced in recent decades, based on earlier work by Noll. The property that a given quantity is a functional of the minimal state is of central interest in the present work. Using a standard representation of a free energy associated with a linear memory constitutive relation, a new condition, involving linear functionals, is derived which, if satisfied, ensures that the free energy is a functional of the minimal state. Using this result and recent work on constructing free energy functionals, it is shown that if the kernel of the rate of dissipation functional …

Evidence That The Dna Mismatch Repair System Removes 1-Nucleotide Okazaki Fragment Flaps., Lyudmila Y Kadyrova, Basanta K Dahal, Farid A Kadyrov

Articles

The DNA mismatch repair (MMR) system plays a major role in promoting genome stability and suppressing carcinogenesis. In this work, we investigated whether the MMR system is involved in Okazaki fragment maturation. We found that in the yeast Saccharomyces cerevisiae, the MMR system and the flap endonuclease Rad27 act in overlapping pathways that protect the nuclear genome from 1-bp insertions. In addition, we determined that purified yeast and human MutSα proteins recognize 1-nucleotide DNA and RNA flaps. In reconstituted human systems, MutSα, proliferating cell nuclear antigen, and replication factor C activate MutLα endonuclease to remove the flaps. ATPase and endonuclease …

Regulatory Textualism, Jennifer Nou

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No abstract provided.

Transnational Class Actions In The Shadow Of Preclusion, Zachary D. Clopton

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No abstract provided.

Contemporary Practice Of The United States Relating To International Law, July 2015, Kristina Daugirdas, Julian Davis Mortenson

Articles

In this section: • Agreement on Iran Nuclear Program Goes into Effect • United States and China Reach Agreement Regarding Economic Espionage and International Cybersecurity Norms • United States Ratifies the International Convention for the Suppression of Acts of Nuclear Terrorism • United States Reaches Agreement with Turkey on Use of Incirlik Air Base for Strikes on ISIL; “Safe Zone” Not Part of the Deal

Balancing Effects Across Markets, Daniel A. Crane

Articles

In Philadelphia National Bank (PNB), the Supreme Court held that it is improper to weigh a merger's procompetitive effects in one market against the merger's anticompetitive effects in another. The merger in question, which ostensibly reduced retail competition in the Philadelphia area, could not be justified on the grounds that it increased competition against New York banks and hence perhaps enhanced competition in business banking in the mid-Atlantic region. I will refer to the Supreme Court's prohibition on balancing effects across markets as a "market-specificity" rule. Under this rule, efficiencies that may counterbalance anticompetitive aspects must be specific to …

New Theory Proven Of Disease And New Ideas And New Methods For Medical Science For Vaccinations, Cures And Treatments Of Diseases, Stephen Smith

Articles

Abstract This research paper for medical science is applying new original further science aimed at curing the Ebola virus and adding to research for the vaccination, curing and treatment of diseases. This research approach achieves the construction of own research from accumulating answers to set goals finding answers to analysis of information of factors associated to disease research and this research adds to medical development needs as observed by actions reported from sources in the news media and from sources in general medical science literature. New theories are presented that apply to medical science involving disease function, new case types, …

The Discovery Sombrero And Other Metaphors For Litigation, William Hubbard

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No abstract provided.

Cold Plasma Inactivation Of Bacterial Biofilms And Reduction Of Quorum Sensing Regulated Virulence Factors, Dana Ziuzina, Daniela Boehm, Sonal Patil, Patrick J. Cullen, Paula Bourke

Articles

The main objectives of this work were to investigate the effect of atmospheric cold plasma (ACP) against a range of microbial biofilms commonly implicated in foodborne and health- care associated human infections and against P. aeruginosa quorum sensing (QS)-regu- lated virulence factors, such as pyocyanin, elastase (Las B) and biofilm formation capacity post-ACP treatment. The effect of processing factors, namely treatment time and mode of plasma exposure on antimicrobial activity of ACP were also examined. Antibiofilm activity was assessed for E. coli, L. monocytogenes and S. aureus in terms of reduction of cultur- ability and retention of metabolic activity using …

Don't Ask, Must Tell—And Other Combinations, Adam M. Samaha, Lior Strahilevitz

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No abstract provided.

Acus - And Administrative Law - Then And Now, Michael Herz

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The Administrative Conference of the United States (ACUS) both shapes and reflects the intellectual, policy, and practical concerns of the field of administrative law. Its recommendations are therefore a useful lens through which to view that field. Also, because of an unfortunate hiatus, ACUS has gotten underway not once but twice. Those two beginnings provide a kind of natural experiment, and they make a revealing contrast. This article traces the transformations of American administrative law, as well as the field’s perpetual concerns, by comparing the initial recommendations of ACUS 1.0 (1968 to 1970) with the initial recommendations of ACUS 2.0 …

Eaf1p Is Required For Recruitment Of Nua4 In Targeting Tfiid To The Promoters Of The Ribosomal Protein Genes For Transcriptional Initiation In Vivo., Bhawana Uprety, Rwik Sen, Sukesh R. Bhaumik

Articles

NuA4 (nucleosome acetyltransferase of H4) promotes transcriptional initiation of TFIID (a complex of TBP and TBP-associated factors [TAFs])-dependent ribosomal protein genes involved in ribosome biogenesis. However, it is not clearly understood how NuA4 regulates the transcription of ribosomal protein genes. Here, we show that NuA4 is recruited to the promoters of ribosomal protein genes, such as RPS5, RPL2B, and RPS11B, for TFIID recruitment to initiate transcription, and the recruitment of NuA4 to these promoters is impaired in the absence of its Eaf1p component. Intriguingly, impaired NuA4 recruitment in a Δeaf1 strain depletes recruitment of TFIID (a TAF-dependent form of TBP) …

Rit Scholar Works User Guide, Frances Andreu

Articles

A procedural overview for accessing and submitting works in RIT Scholar Works. Latest update: October 2015

‘Ireland On A Plate’: Curating The 2011 State Banquet For Queen Elizabeth Ii, Elaine Mahon

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State dining has been shown to define the social, cultural and political position of a nation’s leaders (Albala, 2011; Baughman, 1959; Strong, 2003) and has been used by rulers for centuries to display wealth, cement alliances and impress foreign visitors (Albala, 2007; De Vooght and Scholliers, 2011; Young, 2002). This paper will show how the state banquet for Queen Elizabeth II was carefully curated to represent Ireland’s diplomatic, cultural and culinary identity. As the first visit by a reigning British monarch since Ireland had gained independence from Britain in 1922, the state visit of Queen Elizabeth II to Ireland in …

Peer Victimization And Drd4 Genotype Influence Problem Behaviors In Young Children, Lisabeth Fisher Dilalla, Kyle Bersted, Sufna Gheyara John

Articles

Decades of research supports the presence of significant genetic influences on children’s internalizing (emotional), externalizing (acting out), and social difficulties, including victimization. Additionally, being victimized has been shown to relate to further behavioral problems. The current study assessed the nature of the gene-environment relationships between the DRD4 gene, peer victimization, and externalizing and internalizing difficulties in 6- to 10-year- old children. 174 children (56% girls; 88.6% Caucasian, 3.4% African American, 8% mixed race or Mayan) and their parents were administered victimization and problem behavior questionnaires, and DRD4 was genotyped for the children. An interaction between genes (DRD4) and environment (victimization) …

15 Years On Sirna Delivery: Beyond The State-Of-The-Art On Inorganic Nanoparticles For Rnai Therapeutics, Joao Conde, Furong Tian, Alfredo Ambrosone, Yulán Hernandez, Mark Mccully, Catherine C. .Berry, Pedro Baptista, Claudia Tortiglione, Jesus M. De La Fuented

Articles

RNAi has always captivated scientists due to its tremendous power to modulate the phenotype of living organisms. This natural and powerful biological mechanism can now be harnessed to downregulate specific gene expression in diseased cells, opening up endless opportunities. Since most of the conventional siRNA delivery methods are limited by a narrow therapeutic index and significant side and off-target effects, we are now in the dawn of a new age in gene therapy driven by nanotechnology vehicles for RNAi therapeutics. Here, we outlook the “do's and dont's” of the inorganic RNAi nanomaterials developed in the last 15 years and the …

Protective Properties Of Functionalised Tetrazine On An Aerospace Aluminium Alloy (Aa 2024-T3), Swarna Jaiswal, P.C. Rajath Varma, Brendan Duffy, Felicia Mutuma, Patrick Mchale

Articles

Environmental health concerns over conventional chromium based surface treatments on aluminium substrates are well known. Current research efforts have concentrated on developing protective technologies for multiple applications. Such properties would enable manufacturers to address both corrosion and bacterial threats in areas such as fuel tanks and delivery systems.

The present study explores the anticorrosion properties of 1,2-dihydro 1, 2, 4, 5 tetrazine-3, 6-dicarboxylic acid (H₂DCTZ) on a copper rich aerospace aluminium alloy (AA 2024-T3). Furthermore the antimicrobial activity of the tetrazine is evaluated against Gram-positive and Gram-negative bacteria, both capable of inducing corrosion. The protective action of the …

Computational Analysis And Monte Carlo Simulation Of Wave Propagation, Jun Qin

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No abstract provided.

Numerical Analysis Of Bubble Dynamics In Electrohydraulic And Electromagnetic Shock Wave Lithotripsy, Jun Qin

Articles

This study numerically investigated the bubble dynamics in electrohydraulic (EH) and electromagnetic (EM) shock wave lithotripsy (SWL). The acoustic pressure generated by a typical EH (i.e., Dornier HM-3) and EM (i.e., Siemens Modularis) lithotripters has been measured. The dynamics of cavitation bubbles in SWL has been numerically simulated using the Gilemore formulation coupled with zero-order gas diffusion. The pressure measurement results showed that both the peak positive and negative pressure of the Modularis at E4.0 are slightly higher than the corresponding values of the HM-3 at 20 kV. However, the pressure waveforms generated by an EH lithotripter is different from …

Answering Halliburton Ii's Unanswered Question: Burdens Of Production And Persuasion On Price Impact At Class Certification, Wendy Gerwick Couture

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No abstract provided.

Planning Past Pensions, Julie Roin

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No abstract provided.

Co-Location, Co-Location, Co-Location: Land Use And Housing Priorities Reimagined, Lee Anne Fennell

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No abstract provided.

Constitutional Law, Moral Judgment, And The Supreme Court As Super-Legislature, Brian Leiter

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No abstract provided.

Occupy Judaism: Religion, Digital Media, And The Public Sphere, Ayala Fader, Owen Gottlieb

Articles

This article provides an analysis of Occupy Judaism, an explicitly religious expression of Jewish protest, which occurred simultaneously with Occupy Wall Street, the direct-democracy movement of 2011. Occupy Judaism, like Occupy Wall Street, took place both in physical spaces of protest in New York City and digitally, through mobilizing and circulating debate. The article focuses on the words and actions of Daniel Sieradski, the public face and one of the key founders of Occupy Judaism, supplemented by the experiences of others in Occupy Judaism, Occupy Wall Street, and Occupy Faith (a Protestant clergy-led initiative). We investigate what qualified as religion …

Bioresponsive Antisense Dna Gold Nanobeacons As A Hybrid In Vivo Theranostics Platform For The Inhibition Of Cancer Cells And Metastasis, Chenchen Bao, Joao Conde, James Curtin, Daxiang Cui, Furong Tian, Natalie Artzi

Articles

Gold nanobeacons can be used as a powerful tool for cancer theranostics. Here, we proposed a nanomaterial platform based on gold nanobeacons to detect, target and inhibit the expression of a mutant Kras gene in an in vivo murine gastric cancer model. The conjugation of fluorescently-labeled antisense DNA hairpin oligonucleotides to the surface of gold nanoparticles enables using their localized surface plasmon resonance properties to directly track the delivery to the primary gastric tumor and to lung metastatic sites. The fluorescently labeled nanobeacons reports on the interaction with the target as the fluorescent Cy3 signal is quenched by the gold …

Why Such An Interest In Priests?, Eamon Maher

Articles

Before dealing with any more representations of the priest in modern literature, I thought it might be useful to share some personal experiences which give a context to the origin and inspiration of this series.

Syllable Circles For Pronunciation Learning And Teaching, Charlie Cullen, Keith Gardiner, John B. Whipple

Articles

Syllable Circles is an interactive visualization representing prominence as a feature in short phrases or multi-syllable words. They were designed for Computer Aided Pronunciation Teaching as a part of English Language Teaching. This study explores the question of if and how interactive visualizations can affect English Language Learners’ awareness of prominence, or stress, in English pronunciation. The study followed seven learners and three teachers. Think-aloud protocols, notes from direct observation and interviews of two groups allowed for six streams of data. It was found that interactive visualizations of syllable circles facilitate noticing prominence. Learners and teachers believed interactive visualizations were …

Optimal Choice Of Sample Substrate And Laser Wavelength For Raman Spectroscopic Analysis Of Biological Specimen, Hugh Byrne, Laura Kerr, Bryan M. Hennelly

Articles

Raman spectroscopy is an optical technique based on the inelastic scattering of monochromatic light that can be used to identify

the biomolecular composition of biological cells and tissues. It can be used as both an aid for understanding the etiology

of disease and for accurate clinical diagnostics when combined with multivariate statistical algorithms. This method is nondestructive,potentially non-invasive and can be applied in vitro or in vivo directly or via a fiber optic probe. However, there exists a high degree of variability across experimental protocols, some of which result in large background signals that can often overpower the weak Raman …

Yes, It's Equality, But It's Not What It Used To Be, Edward Brennan

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No abstract provided.

The Realities Of Electoral Reform, Nicholas Stephanopoulos, Eric Mcghee, Steven Rogers

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No abstract provided.