Digital Commons Network^™

Limits Of Detection Of Mycotoxins By Laminar Flow Strips: A Review, Xinyi Zhao, Hugh Byrne, Christine M. O’Connor, James Curtin, Furong Tian

Articles

Mycotoxins are secondary metabolic products of fungi. They are poisonous, carcinogenic, and mutagenic in nature and pose a serious health threat to both humans and animals, causing severe illnesses and even death. Rapid, simple and low-cost methods of detection of mycotoxins are of immense importance and in great demand in the food and beverage industry, as well as in agriculture and environmental monitoring, and, for this purpose, lateral flow immunochromatographic strips (ICSTs) have been widely used in food safety and environmental monitoring. The literature to date describing the development of ICSTs for the detection of different types of mycotoxins using …

Pt Symmetry, Induced Mechanical Lasing, And Tunable Force Sensing In A Coupled-Mode Optically Levitated Nanoparticle, Sandeep Sharma, A. Kani, Mishkatul Bhattacharya

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We theoretically investigate PT symmetry, induced mechanical lasing, and force sensing in an optically levitated nanoparticle with coupled oscillation modes. The coupling in the levitated system is created by the modulation of an asymmetric optical potential in the plane transverse to the beam trapping the nanoparticle. We show that such a coupling can lead to PT -symmetric mechanical behavior for experimentally realistic parameters. Further, by examining the phonon dynamics and the second-order coherence of the nanoparticle modes, we determine that induced mechanical lasing is also possible. Finally, we demonstrate that tunable ultrasensitive force sensing (∼zN/ √H z) can be engineered …

Pt Symmetry, Induced Mechanical Lasing, And Tunable Force Sensing In A Coupled-Mode Optically Levitated Nanoparticle, Sandeep Sharma, A. Kani, Mishkat Bhattacharya

Articles

We theoretically investigate PT symmetry, induced mechanical lasing, and force sensing in an optically levitated nanoparticle with coupled oscillation modes. The coupling in the levitated system is created by the modulation of an asymmetric optical potential in the plane transverse to the beam trapping the nanoparticle. We show that such a coupling can lead to PT-symmetric mechanical behavior for experimentally realistic parameters. Further, by examining the phonon dynamics and the second-order coherence of the nanoparticle modes, we determine that induced mechanical lasing is also possible. Finally, we demonstrate that tunable ultrasensitive force sensing (∼zN/√Hz) can be engineered in the system. …

Ai Insurance: How Liability Insurance Can Drive The Responsible Adoption Of Artificial Intelligence In Health Care, Ariel Dora Stern, Avi Goldfarb, Timo Minssen, W. Nicholson Price Ii

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Despite enthusiasm about the potential to apply artificial intelligence (AI) to medicine and health care delivery, adoption remains tepid, even for the most compelling technologies. In this article, the authors focus on one set of challenges to AI adoption: those related to liability. Well-designed AI liability insurance can mitigate predictable liability risks and uncertainties in a way that is aligned with the interests of health care’s main stakeholders, including patients, physicians, and health care organization leadership. A market for AI insurance will encourage the use of high-quality AI, because insurers will be most keen to underwrite those products that are …

Big Data Analysis Of Vision Screening Standards Used To Evaluate Fitness To Drive, Michael Moore, John Butler, Daniel Ian Flitcroft, James Loughman

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Purpose: Visual acuity (VA) assessment is the most commonly performed vision screening method for drivers. The standards and repeat assessment intervals used, however, are arbitrary, lack an evidence base and are highly variable across different countries. This study utilizes the power of Big Data to provide evidence-based recommendations for standardized driver vision screening.

Methods: Anonymized electronic medical record data were gathered from 40 Irish optometry practices comprising 81,184 unique patients. A Kaplan-Meier Survival (KMS) analysis was used to determine the effect of increasing age and time since screening on the likelihood of passing the VA standard for driving. A logistic …

Essays On Good Practice In Academic Writing: A Comparison Across Business Disciplines, Rawayda Abdou, Kevin Paul Corbett, Elun Hack, Deirdre Mcquillan

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This is a series of essays to support PhD students and early career researchers within the field of business. By delving into a cross disciplinary perspective on academic writing in the business domain, researchers will better understand differences for writing. Essay 1 highlights what is important for writing in economics. Essay 2 adopts a different approach by arguing for more pluralism and applied approaches when writing in Human Resource Management. The essay opens up new possibilities and opportunities for PhD students and early career researchers interested in more applied approaches. Essay 3 guides qualitative researchers writing in sports management where …

Advancing Ubiquitous Collaboration For Telehealth - A Framework To Evaluate Technology-Mediated Collaborative Workflow For Telehealth, Hypertension Exam Workflow Study, Christopher Bondy Ph.D., Linlin Chen Ph.D, Pamela Grover Md, Pengcheng Shi Ph.D

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Healthcare systems are under siege globally regarding technology adoption; the recent pandemic has only magnified the issues. Providers and patients alike look to new enabling technologies to establish real-time connectivity and capability for a growing range of remote telehealth solutions. The migration to new technology is not as seamless as clinicians and patients would like since the new workflows pose new responsibilities and barriers to adoption across the telehealth ecosystem. Technology-mediated workflows (integrated software and personal medical devices) are increasingly important in patient-centered healthcare; software-intense systems will become integral in prescribed treatment plans [1]. My research explored the path to …

Towards An Ethical Framework For The Design And Development Of Inclusive Home-Based Smart Technology For Smart Spaces For Older Adults And People With Disabilities, Emma Murphy, Julie Doyle, Ioannis Stavrakakis, Damian Gordon, Brian Keegan, Dympna O'Sullivan

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Unique ethical, privacy and safety implications arise for people who are reliant on home-based smart technology due to health conditions or disabilities. As a result we need to carefully reflect on our approaches to ethical issues over the life cycle of smart home technology design and the wider living context for end users and relevant stakeholders. In this position paper we highlight a need for a reflective, inclusive ethical framework for the design of inclusive smart spaces. We present key ethical considerations in the design, development and deployment of smart home-based technology for older adults and people with disabilities. We …

A Microfluidic Approach For Synthesis And Kinetic Profiling Of Branched Gold Nanostructures, Qi Cai, Valentina Castagnola, Luca Boselli, Alirio Moura, Hender Lopez, Wei Zhang, João M. De Araújo, Kenneth A. Dawson

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Automatized approaches for nanoparticle synthesis and characterization represent a great asset to their applicability in the biomedical field by improving reproducibility and standardization, which help to meet the selection criteria of regulatory authorities. The scaled-up production of nanoparticles with carefully defined characteristics, including intrinsic morphological features, and minimal intra-batch, batch-to-batch, and operator variability, is an urgent requirement to elevate nanotechnology towards more trustable biological and technological applications. In this work, microfluidic approaches were employed to achieve fast mixing and good reproducibility in synthesizing a variety of gold nanostructures. The microfluidic setup allowed exploiting spatial resolution to investigate the growth evolution …

Probability Models With Discrete And Continuous Parts, James E. Marengo, David L. Farnsworth

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In mathematical statistics courses, students learn that the quadratic function E ((X – x )-squared) is minimized when x is the mean of the random variable X, and that the graphs of this function for any two distributions of X are simply translates of each other. We focus on the problem of minimizing the function defined by y ( x) = E ( IX – xI-squared ) in the context of mixtures of probability distributions of the discrete, absolutely continuous, and singular continuous types. This problem is important, for example, in Bayesian statistics, when one attempts to compute the decision …

Using Phreeqc To Model Cement Hydration, Niall Holmes Dr., Mark Tyrer, Roger P. West Prof, Aaron Lowe, Denis Kelliher

Articles

This paper presents the steps involved in undertaking an analysis of hydrating cements with different levels of limestone powder using the PHREEQC geochemical software with the Notepad++ editor. The analysis begins with determining which solid phases are thermodynamically predicted to precipitate and form using the oxide compositions of commercial CEM I and CEM II/A-L cements. When the phases are known, PHREEQC is programmed to provide predictions of the phase dissolution and phase assemblage over time (here, 1000 days of hydration) as well as the pore solution chemistry. Thermodynamics has been successfully applied to the field of cement hydration to predict …

Contracts In The Age Of Smart Readers, Yonathan A. Arbel, Shmuel I. Becher

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What does it mean to have machines that can read, explain, and evaluate contracts? Recent advances in machine learning have led to a fundamental breakthrough in machine language models, portending a profound shift in the ability of machines to process text. Such a shift has far-reaching consequences for diverse areas of law, which are predicated on, and justified by, the existence of information barriers. Our object here is to provide a general framework for evaluating the legal and policy implications of employing language models as "smart readers"-tools that read, analyze, and assess contracts, disclosures, and privacy policies.

Synthesizing state-of-the-art developments, …

In Vitro Toxicological Evaluation Of Mesoporous Silica Microparticles Functionalised 1 With Carvacrol And Thymol, Cristina Fuentes, Ana Fuentes, Hugh Byrne, José Barat, María José Ruiz

Articles

The cytotoxicity of carvacrol- and thymol- functionalised mesoporous silica microparticles (MCM-41) was assessed in the human hepatocarcinoma cell line (HepG2). Cell viability, lactate dehydrogenase (LDH) activity, reactive oxygen species (ROS) production, mitochondrial membrane potential (ΔΨm), lipid peroxidation (LPO) and apoptosis/necrosis analysis were used as endpoints. Results showed that both materials induced cytotoxicity in a time and concentration-dependent manner, being more cytotoxic than free essential oil components and bare MCM-41. This effect was caused by the cell-particle interactions and not from degradation products released to the culture media, as demonstrated in the extract dilution assays. LDH release was seen to be …

Detecting Patches On Road Pavement Images Acquired With 3d Laser Sensors Using Object Detection And Deep Learning, Syed Ibrahim Hassan, Dympna O'Sullivan, Susan Mckeever, Kieran Feighan, David Power, Ray Mcgowan

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Regular pavement inspections are key to good road maintenance and road defect corrections. Advanced pavement inspection systems such as LCMS (Laser Crack Measurement System) can automatically detect the presence of different defects using 3D lasers. However, such systems still require manual involvement to complete the detection of pavement defects. This paper proposes an automatic patch detection system using object detection technique. To our knowledge, this is the first time state-of-the-art object detection models Faster RCNN, and SSD MobileNet-V2 have been used to detect patches inside images acquired by LCMS. Results show that the object detection model can successfully detect patches …

Assessing Feature Representations For Instance-Based Cross-Domain Anomaly Detection In Cloud Services Univariate Time Series Data, Rahul Agrahari, Matthew Nicholson, Clare Conran, Haytham Assem, John D. Kelleher

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In this paper, we compare and assess the efficacy of a number of time-series instance feature representations for anomaly detection. To assess whether there are statistically significant differences between different feature representations for anomaly detection in a time series, we calculate and compare confidence intervals on the average performance of different feature sets across a number of different model types and cross-domain time-series datasets. Our results indicate that the catch22 time-series feature set augmented with features based on rolling mean and variance performs best on average, and that the difference in performance between this feature set and the next best …

Assessing Feature Representations For Instance-Based Cross-Domain Anomaly Detection In Cloud Services Univariate Time Series Data, Rahul Agrahari, Matthew Nicholson, Clare Conran, Haythem Assem, John D. Kelleher

Articles

In this paper, we compare and assess the efficacy of a number of time-series instance feature representations for anomaly detection. To assess whether there are statistically significant differences between different feature representations for anomaly detection in a time series, we calculate and compare confidence intervals on the average performance of different feature sets across a number of different model types and cross-domain time-series datasets. Our results indicate that the catch22 time-series feature set augmented with features based on rolling mean and variance performs best on average, and that the difference in performance between this feature set and the next best …

Analysis Of Human Gait Cycle With Body Equilibrium Based On Leg Orientation, Muhammad Asif, Muhammad Abdullah Tayyab, Muhammad Hammad Shahid, Usama Arif, Mohsin Islam Tiwana, Umar Shahbaz Khan, Waqar Shahid Qureshi

Articles

Gait analysis identifies the posture during movement in order to provide the correct actions for a normal gait. A person's gait may differ from others and can be recognized by specific patterns. Healthy individuals exhibit normal gait patterns, while lower limb amputees exhibit abnormal gait patterns. To better understand the pitfalls of gait, it is imperative to develop systems capable of capturing the gait patterns of healthy individuals. The main objective of this research was to introduce a new concept in gait analysis by computing the static and dynamic equilibrium in a real-world environment. A relationship was also presented among …

Recruiting, Retaining, And Advancing Women In Stem At An Hbcu:A Model For Institutional Transformation, Sherrice V. Allen, Anna Lee, Maya Corneille, Robin N. Coger, Margaret I. Kanipes, Stephanie Luster-Teasley, Anthony Depass

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Women, especially women of color (WOC), STEM faculty are underrepresented in full professor and leadership positions and overrepresented in non-tenure track positions. It is essential to develop organizational-level approaches which foster equitable and sustainable practices that lead to the success of women STEM faculty at Historically Black Colleges and Universities (HBCUs). The purpose of this paper is to share a model for institutional transformation focusing on recruitment, retention, and advancement of women STEM faculty. We describe our approaches, outcomes, challenges, successes, and lessons learned to serve as a model for other institutions. In order to transform our institution, we focused …

Performance Of Wlan In Downlink Mu-Mimo Channel With The Least Cost In Terms Of Increased Delay, Lemlem Kassa, Jianhua Deng, Mark Davis, Jingye Cai

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To improve the performance of IEEE 802.11 wireless local area (WLAN) networks, different frame-aggregation algorithms are proposed by IEEE 802.11n/ac standards to improve the throughput performance of WLANs. However, this improvement will also have a related cost in terms of increasing delay. The traffic load generated by mixed types of applications in current modern networks demands different network performance requirements in terms of maintaining some form of an optimal trade-off between maximizing throughput and minimizing delay. However, the majority of existing researchers have only attempted to optimize either one (to maximize throughput or minimize the delay). Both the performance of …

Evaluating A Peer Assisted Learning Programme For Mature Access Foundation Students Undertaking Computer Programming At An Irish University, Nevan Bermingham, Frances Boylan, Barry J. Ryan

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Access Foundation Programmes are a widening-participation initiative designed to encourage engagement in higher education among under-represented groups. This includes socioeconomic and educational disadvantage. Mature students in particular enrolled on these programmes experience greater difficulties making the transition to tertiary education, especially when they opt to study disciplines traditionally considered difficult. Computer programming is perceived as a traditionally difficult subject with lower pass rates and progression rates typically than other subjects.

This paper describes the first of a three-cycle action research study examining the perceived effects of a structured Peer Assisted Learning (PAL) Programme for mature students enrolled on a computer …

Narratives Of Black Women Stem Faculty: Breaking Barriers To Promote Institutional Transformation At Historically Black Colleges And Universities, Anna Lee, Maya Corneille, Karen T. Jackson, Bahby Banks, Sherrice Allen, Robin N. Coger, Margaret I. Kanipes, Stephanie Luster-Teasley

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Women faculty at Historically Black Colleges and Universities (HBCUs), experience many barriers. HBCUs’ rich histories of advancing racial equity have often outweighed a focus on gender equity, with issues at the intersection of race and gender receiving minimal attention. This study highlights the need for institutional transformation at HBCUs by identifying the structural factors that promote and inhibit Black women STEM faculty advancement. Interviews (n=15) were conducted with HBCU Black women STEM faculty using the Life Interview approach. The three major themes related to barriers included: (a) greater likelihood of having their expertise questioned, (b) increased pressure to work harder, …

Micro-Rna And Proteomic Profiles Of Plasma-Derived Exosomes From Irradiated Mice Reveal Molecular Changes Preventing Apoptosis In Neonatal Cerebellum, Simonetta Pazzaglia, Barbara Tanno, Ilaria De Stefano, Paola Giardullo, Simona Leonardi, Caterina Merla, Gabriele Babini, Seda Tuncay Cagatay, Ammar Mayah, Munira Kadhim, Fiona Lyng, Christine Von Toerne, Zohaib N. Khan, Prabal Subedi, Soile Tapio, Anna Saran, Mariateresa Mancuso

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Cell communication via exosomes is capable of influencing cell fate in stress situations such as exposure to ionizing radiation. In vitro and in vivo studies have shown that exosomes might play a role in out-of-target radiation effects by carrying molecular signaling mediators of radiation damage, as well as opposite protective functions resulting in resistance to radiotherapy. However, a global understanding of exosomes and their radiation-induced regulation, especially within the context of an intact mammalian organism, has been lacking. In this in vivo study, we demonstrate that, compared to sham-irradiated (SI) mice, a distinct pattern of proteins and miRNAs is found …

Advancing Competency In Managing Risk And Knowledge: Steps Toward Operationalisation Of The Risk-Knowledge Infinity Cycle (Rki Cycle) Part 3: Uncovering Knowledge For Qrm Through Knowledge Mapping At Node 1, Martin Lipa, Valerie Mulholland, Anne Greene

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To date, literature on the Risk-Knowledge Infinity Cycle (RKI Cycle) has mainly been theoretical. This paper series intent is to focus on the operationalisation of the RKI Cycle by describing a series of steps – the “How to” – for RKI Cycle deployment, to help move the RKI Cycle from theory to practice. The third paper in this series focuses on ensuring the best available knowledge flows into QRM through a case study demonstrating knowledge mapping to support effective quality risk assessment during commissioning and qualification activities.

Development And Validation Of A Raman Spectroscopic Classification Model For Cervical Intraepithelial Neoplasia (Cin), Damien Traynor, Shiyamala Duraipandian, Ramya Bhatia, Kate Cuschieri, Prerna Tewari, Padraig Kearney, Tom D'Arcy, John J. O'Leary, Cara M. Martin, Fiona Lyng

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The mortality associated with cervical cancer can be reduced if detected at the precancer stage, but current methods are limited in terms of subjectivity, cost and time. Optical spectroscopic methods such as Raman spectroscopy can provide a rapid, label-free and nondestructive measurement of the biochemical fingerprint of a cell, tissue or biofluid. Previous studies have shown the potential of Raman spectroscopy for cervical cancer diagnosis, but most were pilot studies with small sample sizes. The aim of this study is to show the clinical utility of Raman spectroscopy for identifying cervical precancer in a large sample set with validation in …

The Legal Envelope Theorem, David A. Weisbach, Daniel J. Hemel

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Nontax legal rules regulating the workplace, the financial sector, real property, and many other areas affect the ability of governments to collect revenues and provide public goods. Yet tax-collection considerations rarely enter into economic analyses of nontax legal rules. Usually, tax-collection concerns are shunted aside to separate studies (and separate law school courses) rather than integrated into debates in nontax spheres. This separation between nontax legal rules and tax-collection considerations bears significant negative consequences for the ability of law and economics to generate descriptively accurate and normatively attractive accounts of important nontax legal questions.

This Article takes a step toward …

The Epistemology Of The Internet And The Regulation Of Speech In America, Brian Leiter

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The Internet is the epistemological crisis of the 21st century: it has fundamentally altered the social epistemology of societies with relative freedom to access it. Most of what we think we know about the world is due to reliance on epistemic authorities, individuals, or institutions that tell us what we ought to believe about Newtonian mechanics, evolution by natural selection, climate change, resurrection from the dead, or the Holocaust. The most practically fruitful epistemic norm of modernity, empiricism, demands that knowledge be grounded in sensory experience, but almost no one who believes in evolution by natural selection or the reality …

The 4c’S Of Pal – An Evidence-Based Model For Implementing Peer Assisted Learning For Mature Students, Nevan Bermingham, Frances Boylan, Barry J. Ryan

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Peer Assisted Leaning (PAL) programmes have been shown to enhance learner confidence and have an overall positive effect on learner comprehension, particularly in subjects traditionally perceived as difficult. This research describes the findings of a three-cycle Action Research study into the perceived benefits of implementing such a programme for mature students enrolled on a computer science programming module on an Access Foundation Programme in an Irish University. The findings from this study suggest that peer learning programmes offer students a valued support structure that aids transition and acculturation into tertiary education whilst simultaneously improving their subject-matter comprehension and confidence. An …

Satdbailiff- Mining And Tracking Self-Admitted Technical Debt, Mohamed Wiem Mkaouer, Eman Abdullah Alomar, Ben Christians, Mihal Busho, Ahmed Hamad Alkhalid, Christian D. Newman

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Self-Admitted Technical Debt (SATD) is a metaphorical concept to describe the self-documented addition of technical debt to a software project in the form of source code comments. SATD can linger in projects and degrade source-code quality, but it can also be more visible than unintentionally added or undocumented technical debt. Understanding the implications of adding SATD to a software project is important because developers can benefit from a better understanding of the quality trade-offs they are making. However, empirical studies, analyzing the survivability and removal of SATD comments, are challenged by potential code changes or SATD comment updates that may …

Evaluation Of The Potential Of Nanofluids Containing Different Ag Nanoparticle Size Distributions For Enhanced Solar Energy Conversion In Hybrid Photovoltaic-Thermal (Pvt) Applications, James Walshe, John Doran, George Amarandei

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Hybridising photovoltaic and photothermal technologies into a single system that can simultaneously deliver heat and power represents one of the leading strategies for generating clean energy at more affordable prices. In a hybrid photovoltaic-thermal (PVT) system, the capability to modulate the thermal and electrical power output is significantly influenced by the spectral properties of the heat transfer fluid utilised. In this study, we report on one of the first experimental evaluations of the capability of a multimodal silver nanofluid containing various particle shapes and particle sizes to selectively modulate the solar energy for PVT applications. The diverse set of particle …

Fifty Years Of Patent Remedies Case Law: Two Steps Forward, One Step Back, Thomas F. Cotter

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Over the past fifty years, courts have developed a body of case law on patent remedies that is, in many respects, solidly grounded in economic reasoning. Among the high points are the courts’ embrace, in various contexts, of the simple principle that patent damages should restore patent owners to the position they would have occupied, but for the infringement—and of an important corollary to that principle, namely the importance to damages calculations of the “noninfringing alternatives” concept. By contrast, certain other developments—including the confusing standards for determining when it is appropriate to use the “entire market value” of a product …