Digital Commons Network^™

Prediction Of Pathological Response To Neo‐Adjuvant Chemoradiotherapy For Oesophageal Cancer Using Vibrational Spectroscopy, Thi Nguyet Que Nguyen, Adrian Maguire, Catherine Mooney, Naomi Jackson, Niamh Lynam-Lennon, Vicki Weldon, Cian Muldoon, Aoife Maguire, Dermot O'Toole, Narayanasamy Ravi, John V. Reynolds, Jacintha O'Sullivan, Aidan Meade

Articles

No abstract provided.

Dual Contrast In Computed Tomography Allows Earlier Characterization Of Articular Cartilage Over Single Contrast, Abhisek Bhattarai, Behdad Pouran, Janne T.A. Mäkelä, Rubina Shaikh, Miitu K.M. Honkanen, Mithilesh Prakash, Heikki Kröger, Mark W. Grinstaff, Harrie Weinans, Jukka S. Jurvelin, Juha Töyräs

Articles

Cationic computed tomography contrast agents are more sensitive for detecting cartilage degeneration than anionic or non-ionic agents. However, osteoarthritis-related loss of proteoglycans and increase in water content contrarily affect the diffusion of cationic contrast agents, limiting their sensitivity. The quantitative dual-energy computed tomography technique allows the simultaneous determination of the partitions of iodine-based cationic (CA4+) and gadolinium-based non-ionic (gadoteridol) agents in cartilage at diffusion equilibrium. Normalizing the cationic agent partition at diffusion equilibrium with that of the non-ionic agent improves diagnostic sensitivity. We hypothesize that this sensitivity improvement is also prominent during early diffusion time points and that the technique …

A Culturally Competent Phenotypic Evaluation / Obesity Assessment In African And African American Populations: Pilot Study, Catrina Johnson, Robert Corrucini, Daniel Beque, Wanki Moon, Kola Ajuwon, David A. Lightfoot

Articles

BMI, a ratio of weight over height, is a culturally-biased tool imposed upon the scientific, academic and medical communities as an errant measure of obesity across ethnic - ity. Body Mass Index (BMI) relates mass (g) to a relative fat distribution with regards to height. Its genesis is from the actuarially derived and ethnically exclusive height and weight tables that promote the fictional notion of inter-eth - nic ideal weights that would be later adopted by the Na - tional Institutes of Health (NIH) as a competent measure of adiposity. Best practice, movement towards individualized medicine and deployment of effective …

Help-Seeking From A Counsellor Or Psychotherapist: A Cross-Sectional Study Of Irish Adults, Damien Cassells

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The factors that contribute towards an individual seeking help from a counsellor or psychotherapist for a mental, nervous or emotional problem are explored in this study. A multivariate logistic regression is applied to analyse data from the 2006 National Psychological Wellbeing and Distress Survey. Individuals living in rural areas and in towns with populations of between 5,000 and 10,000 people are found to be less likely to seek counselling, relative to individuals living in Dublin City. Respondents earning the lowest income were less likely to enter therapy compared with respondents earning the highest, while having private health insurance increased the …

Food Preferences Survey In African Americans And West Africans: A Cultural Exploration Of Agreement And Divergence In Attitudes In Food Environments And Food Responses, Catrina Johnson, Robert Corrichini, Daniel Becque, Wanki Moon, Kola Ajuwon, David A. Lightfoot

Articles

African Americans, currently over-represented among low SES groups, have been found to be among the most at risk groups for obesity and type 2 diabetes. Phenotypic expression, such as obesity, result from the combined effect of genetic inheritance and environmental influences. Environmental dynamics interact with individuals on micro, meso and ecto levels (Bronfrenbrenner, 1989), are diverse and cultural (Vygotsky, 1993) and are learned by individuals through modeling and observation (Bandura, 1989). Environmental factors such as parental influence and modeling, availability and accessibility of produce, sweetened drinks and fast foods, can contribute to or minimize the onset of obesity and type …

Select Criminal Law And Procedure Cases From The U.S. Supreme Court's 2018-2019 Term, Eve Brensike Primus, Kristin Froehle

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Although the 2018-19 Term at the Supreme Court did not include any blockbuster rulings like Carpenter v. United States, the Court issued a number of significant criminal law and procedure rulings. It addressed warrantless blood-alcohol testing, the dual-sovereignty doctrine, the right to trial by jury, ineffective assistance of trial counsel, questions of incorporation, prisoners' competence to be executed, permissible methods of execution, and some important statutory interpretation questions. Looking back on the Term, Justice Gorsuch clearly solidified his position as the libertarian "swing" vote in criminal procedure cases. He joined the liberals to uphold a defendant's right to trial …

School Of Culinary Arts & Food Technology, Technological University Dublin Newsletter: Winter, 2019, James Murphy

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The School of Culinary Arts and Food Technology, TU Dublin, Winter Newsletter captured the many events, research, awards, significant contributions and special civic and community activities which the students and staff members of the school have successfully completed up to the Winter period of 2019. The successful completion of these activities would not be possible without the active and on-going support of the 'INSPIRED' friends of Culinary Arts (school supporters) and our school's industry association supporters.

Be Media Smart: A National Media Literacy Campaign For Ireland, Philip Russell

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‘Be Media Smart’ is an Irish public awareness campaign calling on people of all ages to ‘Be Media Smart’ and ‘Stop, Think, and Check’ that information they see, read or hear across any media platform is accurate and reliable. This national media literacy campaign was aimed at enhancing people’s understanding of, and engagement with, media, while also empowering them with the skills to evaluate content across all platforms.

Engineering Education Through Problem Based Learning: A Case Study Of Teaching Mechanical Engineering Design In Tu Dublin, Kevin Delaney, Ger Nagle

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Undergraduate students, having learnt to quantify the performance of specific elements of engineering objects, often find it difficult to integrate these elements into quite basic design concepts. Employers expect these engineering graduates to be able to do a great deal more than solve the technical problems taught in engineering school once they enter the workforce. To help students meet this expectation by developing real-world engineering skills as part of their engineering education, the Mechanical Engineering Discipline in Technological University Dublin (TU Dublin) introduced Problem Based Learning (PBL) module for Third Year Mechanical Engineering students in 2005. This module was well …

A Generalisable Bottom-Up Methodology For Deriving A Residential Stock Model From Large Empirical Databases, Ciara Ahern, Brian Norton

Articles

Specifying representative reference buildings as a prerequisite for calculating cost-optimal energy performance requirements for buildings and building elements. Appropriate characterisation is prerequisite data for an overall national building energy consumption model to produce valid outcomes. Energy Performance Certificates (EPCs) are issued in the EU, for dwellings whenever they are constructed, sold or leased. Where acquiring data for an EPC would be prohibitively costly, nationally applicable default-values are employed for the building envelope thermal transmittance coefficients. Significant levels of retrofits led to the default-values used now being higher than is typical in reality, leading to characterisations of reference dwellings based on …

My Palate Hung With Starlight: A Gastrocritical Reading Of Seamus Heaney’S Poetry, Anke Klitzing

Articles

Nobel-prize winning poet Seamus Heaney is celebrated for his rich verses recalling his home in the Northern Irish countryside of County Derry. Yet while the imaginative links to nature in his poetry have already been critically explored, little attention has been paid so far to his rendering of local food and foodways. From ploughing, digging potatoes and butter-churning to picking blackberries, Heaney sketches not only the everyday activities of mid-20th century rural Ireland, but also the social dynamics of community and identity and the socio-cultural symbiosis embedded in those practices. Larger questions of love, life and death also infiltrate the …

Addiction-Informed Immigration Reform, Rebecca Sharpless

Articles

Immigration law fails to align with the contemporary understanding of substance addiction as a medical condition. The Immigration and Nationality Act regards noncitizens who suffer from drug or alcohol substance use disorder as immoral and undesirable. Addiction is a ground of exclusion and deportation and can prevent the finding of "good moral character" needed for certain immigration applications. Substance use disorder can lead to criminal behavior that lands noncitizens, including lawful permanent residents, in removal proceedings with no defense. The time has come for immigration law to catch up to today's understanding of addiction. The damage done by failing to …

An Explorative Case-Study Of The Use Of Peerwise To Foster Student Centred, And Peer Supported, Learning In A First-Year Business Module, Anna Dynan, Barry Ryan

Articles

Peer based learning is not a new concept in business studies in higher education; however, the integration of technology enabled and asynchronous peer learning has limited reported use and even less evidence based evaluation. In this explorative case study, the online tool PeerWise was used to scaffold and support an asynchronous peer-learning environment for a group of 212 first year business studies students. Students were required to create, answer and rate multiple choice questions on topics aligned to their curriculum within the peer constructed PeerWise question database. While there was no statistically significant correlation between PeerWise engagement and final module …

Have You Asked For It?: An Exploratory Study About Maltese Adolescents’ Use Of Ask. Fm, Lorleen Farrugia, Mary Ann Lauri, Joseph Borg, Brian O'Neill

Articles

This article focuses on adolescents’ use of anonymous social networking sites (SNSs). Their perceptions and attitudes toward one such platform, Ask.fm, are discussed using the framework of uses and gratifications theory to explore motivations for using it. Four focus groups and four interviews were carried out with 22 Maltese adolescents (10 female and 12 male) aged 11 to 16 years. Thematic analysis of data collected was undertaken to identify and develop themes relevant to Ask.fm use. Findings indicate that the platform is a space where adolescents interact with others as part of their identity exploration. The role of anonymity was …

A Hidden Technological Assumption In Patent Law: The Case Of Gene Patents And The Disclosure Requirement, Or Cohen Sasson

Articles

The disclosure requirement in patent law is designed to reveal knowledge regarding a patented invention to allow proper understanding and utilization of that invention. The contention offered here is the presence of an inherent incompatibility between the disclosure requirement and genetic inventions. Genetic inventions are highly contingent on genetic statistical data (GSD), which is gathered during the commercial phase of a genetic invention. GSD are essential for various purposes, which at least some should be satisfied by the disclosure. However, since GSD can be gathered only at the postapplication period, GSD are not disclosed through the disclosure requirement. Therefore, there …

The Lawyer As Accomplice: Cannabis, Uber, Airbnb, And The Ethics Of Advising “Disruptive” Businesses, Charles M. Yablon

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This Article examines the legal and ethical problems of corporate lawyers who advise businesses that operate just beyond the edge of legality. These include manufacturers and sellers of cannabis products (a felony under federal law, even if ostensibly permitted by state statutes) as well as a substantial number of startup companies, like Uber and Airbnb, whose “disruptive” business models involve deliberately violating local laws and ordinances, many of which carry criminal penalties. Under the current Model Rules of Professional Conduct, a lawyer “shall not counsel a client to engage, or assist a client, in conduct that the lawyer knows is …

Prenatal Drug Exposure As Aggravated Circumstances, Frank E. Vandervort

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In Michigan, "a child has a legal right to begin life with sound mind and body." Yet the family court may not assert Juvenile Code jurisdiction until after birth. In re Baby X addressed the question of whether a parent's prenatal conduct may form the basis for jurisdiction upon birth. It held that a mother's drug use during pregnancy is neglect, allowing the court to assert jurisdiction immediately upon the child's birth. In deciding Baby X, the Court specifically reserved the question of whether parental drug use during pregnancy might be sufficient to permanently deprive a parent of custody. …

Thermal Energy Refurbishment Status Of The Irish Housing Stock, Ciara Ahern, Brian Norton

Articles

Energy Performance Certificates (EPCs) are issued for buildings constructed, sold or leased across the EU. Using a generalizable methodology this work exploits Ireland's EPC national dwelling stock database to determine the thermal refurbishment status of Ireland's housing stock. It is estimated in 2014 that; i) 58% of walls were insulated at a mean overall heat loss coefficient or U-value of 0.66 W/m²K, ii) 67% of roofs were insulated at a mean U-value 0.37 W/m²K, iii) 97% of windows were double-glazed, and iv) 53% of floors were insulated to a mean U-value of 0.59 W/m²K. …

Fine-Scale Haplotype Structure Reveals Strong Signatures Of Positive Selection In A Recombining Bacterial Pathogen, Brian Arnold, Mashaal Sohail, Crista B. Wadsworth, Jukka Corander, William P. Hanage, Shamil Sunyaev, Yonatan H. Grad

Articles

Identifying genetic variation in bacteria that has been shaped by ecological differences remains an important challenge. For recombining bacteria, the sign and strength of linkage provide a unique lens into ongoing selection. We show that derived alleles linkage, a pattern that cannot be explained by limited recombination or neutrality as these couplings are significantly stronger for nonsynonymous alleles than synonymous alleles. This general pattern is driven by a small fraction of highly diverse genes, many of which exhibit evidence of interspecies horizontal gene transfer and an excess of intermediate frequency alleles. Extensive simulations show that two distinct forms of positive …

Nonprofit College Crash: Enforcing Board Fiduciaries Through Increased Accountability And Transparency In The Irs Form 990 Procedure, Kaleb Paul Byars

Articles

Since 1997, the United States has experienced a steady increase in college closings. Private, nonprofit colleges are the most prevalent among these affected institutions. A 2017 study confirmed that 177 colleges failed a U.S. Education Department test for “financial responsibility.” Of these 177 colleges, well over half are private nonprofits. Further, several colleges have closed since the study was completed. It is reasonable to conclude the financial irresponsibility of these schools contributes to their closures. ...

Part I describes fiduciary duties of nonprofit board members and instances of their failure. Part II discusses inadequate nonprofit oversight and provides information regarding …

What Can The Apple Teach The Orange? Lessons U.S. Land Trusts Can Learn From The National Trust In The U.K., Jessica Owley, Lauren Gwin, Sally K. Fairfax

Articles

The National Trust in England, Wales, and Northern Ireland is one of the oldest and most revered private land conservation organizations in the world. While the private land conservation movements in the United States and the United Kingdom began at a similar time and with similar tools, conservation attitudes and methods in the two countries diverged. Today, the National Trust dominates land conservation in the U.K. while the strength of the U.S. movement is the energy of over 1,500 smaller organizations operating at different scales across the country. Despite the differences, this project looks to the National Trust in England …

Potential Liability For Physicians Using Artificial Intelligence, W. Nicholson Price Ii, Sara Gerke, I Glenn Cohen

Articles

Artificial intelligence (AI) is quickly making inroads into medical practice, especially in forms that rely on machine learning, with a mix of hope and hype. Multiple AI-based products have now been approved or cleared by the US Food and Drug Administration (FDA), and health systems and hospitals are increasingly deploying AI-based systems. For example, medical AI can support clinical decisions, such as recommending drugs or dosages or interpreting radiological images.2 One key difference from most traditional clinical decision support software is that some medical AI may communicate results or recommendations to the care team without being able to communicate the …

Thermal Refurbishment Status Of The Irish Housing Stock, Ciara Ahern, Brian Norton

Articles

Energy Performance Certificates (EPCs) are issued for buildings constructed, sold or leased across the EU. Using a generalizable methodology this work exploits Ireland’s EPC national dwelling stock database to determine the thermal refurbishment status of Ireland’s housing stock. It is estimated in 2014 that; i) 58% of walls were insulated at a mean overall heat loss coefficient or U-value of 0.66 W/m 2 K, ii) 67% of roofs were insulated at a mean U-value 0.37 W/m 2 K, iii) 97% of windows were double-glazed, and iv) 53% of floors were insulated to a mean U-value of 0.59 W/m 2 K. …

Low-Dose (0.01%) Atropine Eye Drops To Reduce Progression Of Myopia In Children: A Multi-Centre Placebo- Controlled Randomised Trial In The United Kingdom (Champ- Uk) – Study Protocol., Augusto Azuara-Blanco, Nicola Logan, Niall Strang, Peter Allen, Ruth Hogg, Ruth Weir, Paul Doherty, Catherine Adams, Margaret Mcfarland, Evie Gardner, Rejina Verghis, Jennifer Preston, James Loughman, Daniel I. Flintcroft, David Mackey, Samantha Lee, Christopher Hammond, Nathan Congdon, Mike Clarke

Articles

Background/aims To report the protocol of a trial designed to evaluate the efficacy, safety and mechanism of action of low-dose atropine (0.01%) eye-drops for reducing progression of myopia in UK children. Methods Multicentre, double-masked, superiority, placebo-controlled, randomised trial. We will enrol children aged 6–12 years with myopia of −0.50 dioptres or worse in both eyes. We will recruit 289 participants with an allocation ratio of 2:1 (193 atropine; 96 placebo) from five centres. Participants will instil one drop in each eye every day for 2 years and attend a research centre every 6 months. The vehicle and preservative will be …

Data Mining Raman Microspectroscopic Responses Of Cells To Drugs In Vitro Using Multivariate Curve Resolution-Alternating Least Squares, David Perez-Guaita, Guillermo Quintas, Zeineb Farhane, Roma Tauler, Hugh Byrne

Articles

Raman microspectroscopy is gaining popularity for the analysis of time-dependent biological processes such as drug uptake and cellular response. It is a label-free technique which acquires signals from a large variety of components, including cell biomolecules and exogenous compounds such as drugs and nanoparticles, and is commonly employed for in vitro analysis of cells and cell populations with no labelling or staining required. By monitoring the changes to the Raman spectra of the cell as a result of a perturbing agent (e.g. inoculation of a drug or toxic agent), one can study the associated changes in cell biochemistry involved in …

The Effect Of Calcium Alginate Entrapment On The Stability Of Novel Lipases From P. Reinekei And P. Brenneri, Priyanka Priyanka, Gemma K. Kinsella, Gary T. Henehan, Barry J. Ryan

Articles

The high cost of soluble enzymes can limit their use for commercial and industrial purposes. Immobilization can enhance enzyme reusability, thereby reducing product isolation costs and overcoming this economic barrier. In the current study, two novel, purified lipases from Pseudomonas sp. (Pseudomonas reinekei and Pseudomonas brenneri) were entrapped in a calcium alginate matrix, with the aim of simultaneously enhancing enzyme reusability and stability. Following entrapment, the retained activity of the enzyme-alginate composite was verified by an enzymatic hydrolysis reaction of a p-nitrophenol palmitate substrate. The effect of the enzyme-alginate entrapment against various physiochemical parameters such as pH, temperature, metal ions, …

New Textualism And The Thirteenth Amendment, Leah Litman

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Michele Goodwin’s piece raises important questions about whether troubling modern-day labor practices in jails and prisons are consistent with the Thirteenth Amendment. In Goodwin’s telling, the ratification of the Thirteenth Amendment formally ended the institution of slavery, but the Amendment allowed practices resembling slavery to continue, perhaps reflecting the extant stereotypes and racism that formally amending the Constitution cannot root out. Indeed, Goodwin excavates historical materials that suggest the people who drafted and ratified the Amendment understood and expected that it would allow the perpetuation of slavery in another form. As Goodwin explains, most historians have argued that the Thirteenth …

Response To: How Should We Respond To Pregnancy And Substance Use?, Frank E. E. Vandervort, Vincent J. Palusci

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We begin our reply by asking the reader to consider this typical case taken from Professor Vandervort’s current practice. It is one of several similar cases currently being handled by the clinic he works in and similar to many dozens—perhaps hundreds—of cases handled over the past 30 years.

To Protect And Provide For Children, Prenatal Substance Use Must Be Considered Abuse., Frank E. E. Vandervort, Vincent J. Palusci

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The use of drugs and alcohol during pregnancy is harmful to the developing child. When children are born having been exposed to these substances, children’s protective services should uniformly substantiate child maltreatment in order to ensure that the child’s parent(s) and the child receive the treatment and services necessary to address the child’s immediate safety, protect the government’s compelling interest in the child’s welfare, and ensure the best long-term outcome for the child.

Returning Home When Immigration Fails: Risk Factors And The Need For Improved Care, Albina Balidemaj, Small, Mark

Articles

Migrating is stressful. Even under the best of circumstances, voluntarily moving from one’s home country to another country requires careful consideration of several potentially stressful factors. A non-exhaustive list would include transportation, housing, finances, social support, language proficiency, and acculturation issues. In 2017, an estimated 68 million persons involuntarily migrated – 40 million internally displaced persons, 25 million refugees and 3 million asylum seekers (United Nations, 2017). Forcible displacement puts individuals and families at even greater risk of stress related to moving – as there is generally less time available for planning. What happens when immigration fails, particularly for those …