Digital Commons Network^™

Microrna Analysis Of Atm-Deficient Cells Indicate Pten And Ccdn1 As Potential Biomarkers Of Radiation Response, Jane Bryant, Lisa White, Natasha Coen, Laura Shields, Brendan Mcclean, Aidan Meade, Fiona Lyng, Orla L. Howe

Articles

Genetic and epigenetic profile changes associated with individual radiation sensitivity are well documented and have led to enhanced understanding of the mechanisms of the radiation-induced DNA damage response. However, the search continues to identify reliable biomarkers of individual radiation sensitivity. Herein, we report on a multi-biomarker approach using traditional cytogenetic biomarkers, DNA damage biomarkers and transcriptional microRNA (miR) biomarkers coupled with their potential gene targets to identify radiosensitivity in ataxia-telangiectasia mutated (ATM)-deficient lymphoblastoid cell lines (LCL); ATM-proficient cell lines were used as controls. Cells were 0.05 and 0.5 Gy irradiated, using a linear accelerator, with sham-irradiated cells as controls. At …

Preoperative Exercise To Improve Fitness In Patients Undergoing Complex Surgery For Cancer Of The Lung Or Oesophagus (Pre-Hiit): Protocol For A Randomized Controlled Trial, Grainne Sheill, Emer Guinan, Linda O'Neill, Charles Normand, Suzanne Doyle, Sarah Moore, John Newell, Granne Mcdermott, Ronan Ryan, John V. Reynolds, Juliette Hussey

Articles

Patients with cancer of the lung or oesophagus, undergoing curative treatment, usually require a thoracotomy and a complex oncological resection. These surgeries carry a risk of major morbidity and mortality, and risk assessment, preoperative optimisation, and enhanced recovery after surgery (ERAS) pathways are modern approaches to optimise outcomes. Pre-operative fitness is an established predictor of postoperative outcome, accordingly, targeting pre-operative fitness through exercise prehabilitation has logical appeal. Exercise prehabilitation is challenging to implement however due to the short opportunity for intervention between diagnosis and surgery. Therefore, individually prescribed, intensive exercise training protocols which convey clinically meaningful improvements in cardiopulmonary fitness …

In Vivo Activity Of Copper(Ii), Manganese(Ii), And Silver(I) 1,10-Phenanthroline Chelates, Rafael M. Ghandra, Pauraic Mccarron, Livia Viganor, Mariana Farias Fernandes, Kevin Kavanagh, Malachy Mccann, Marta H. Branquinha, André L.S. Santos, Orla L. Howe, Michael Devereux

Articles

Candida haemulonii is an emerging opportunistic pathogen resistant to most antifungal drugs currently used in clinical arena. Metal complexes containing 1,10-phenanthroline (phen) chelating ligands have well-established anti-Candida activity against different medically relevant species. This study utilized larvae of Galleria mellonella, a widely used model of in vivo infection, to examine C. haemulonii infection characteristics in response to different copper(II), manganese(II), and silver(I) chelates containing phen, which had demonstrated potent anti-C. haemulonii activity in a previous study. The results showed that C. haemulonii virulence was influenced by inoculum size and incubation temperature, and the host G. mellonella immune …

I Was Determined To Breastfeed, And I Always Found A Solution: Successful Experiences Of Exclusive Breastfeeding Among Chinese Mothers In Ireland, John Kearney, Qianling Zhou, Haoyue Chen, Katherine Younger, Tanya M. Cassidy

Articles

Background: The prevalence of exclusive breastfeeding for at least 4 months was previously found to be very low among Chinese immigrants in Ireland, at 5.8% (Zhou et al., Front Public Health 6:351, 2018). This study investigates the successful experiences of Chinese mothers living in Ireland who exclusively breastfeed for between four and 6 months.

Methods: Participants were recruited from the sample of the Ireland Chinese Mother Survey. Qualitative in-depth interviews were conducted with fourteen participants in their homes or public places.

Results: A content analysis revealed that various factors contributed to a successful experience of exclusive breastfeeding among the group …

Vibrational Spectroscopy Of Liquid Biopsies For Prostate Cancer Diagnosis, Dinesh Medipally, Daniel Cullen, Valérie Untereiner, G.D. Sockalingum, Adrian Maguire, T.N.Q. Nguyen, Jane Bryant, Emma Noone, Shirley Bradshaw, Marie Finn, Mary Dunne, Aoife M. Shannon, John Armstrong, Aidan Meade, Fiona Lyng

Articles

Background: Screening for prostate cancer with prostate specific antigen and digital rectal examination allows early diagnosis of prostate malignancy but has been associated with poor sensitivity and specificity. There is also a considerable risk of over-diagnosis and overtreatment, which highlights the need for better tools for diagnosis of prostate cancer. This study investigates the potential of high throughput Raman and Fourier Transform Infrared (FTIR) spectroscopy of liquid biopsies for rapid and accurate diagnosis of prostate cancer.

Methods: Blood samples (plasma and lymphocytes) were obtained from healthy control subjects and prostate cancer patients. FTIR and Raman spectra were recorded from plasma …

A Novel Pool Of Microparticle Cholesterol Is Elevatedin Rheumatoid Arthritis But Not In Systemic Lupus Erythematosus Patients, Shuai Shuai Hu, Brenton L. Cavanagh, Robert Harrington, Muddassar Ahmad, Grainne Kearns, Steve Meaney, Claire Wynne

Articles

Microparticles are sub-micron, membrane-bound particles released from virtually allcells and which are present in the circulation. In several autoimmune disorders their amountand composition in the circulation is altered. Microparticle surface protein expression has beenexplored as a differentiating tool in autoimmune disorders where the clinical pictures can overlap.Here, we examine the utility of a novel lipid-based marker—microparticle cholesterol, present in allmicroparticles regardless of cellular origin—to distinguish between rheumatoid arthritis (RA) andsystemic lupus erythematosus (SLE). We first isolated a series of microparticle containing lipoproteindeficient fractions from patient and control plasma. There were no significant differences in thesize, structure or protein content of …

Are Maternal Feeding Practices And Mealtime Emotions Associated With Toddlers’ Food Neophobia?A Follow-Up To The Dit-Coombe Hospital Birth Cohort In Ireland, Meijing An, Qianling Zhou, Katherine Younger, Xiyao Liu, John M. Kearney

Articles

This study was conducted to explore the associations between maternal feeding practices,mealtime emotions, as well as maternal food neophobia and toddlers’ food neophobia in Ireland.A follow-up to the Technological University Dublin (DIT)-Coombe Hospital birth cohort wasconducted. Mothers in the original cohort were invited to the present study by telephone calls.Postal questionnaires with stamped addressed envelopes were distributed to those who agreed toparticipate in the study. Toddler food neophobia was assessed by the modified version of the ChildFood Neophobia Scale (CFNS). There were 205 participants included in this study, with a median scoreof child food neophobia of 12. A higher degree …

Associations Between The Home Environment, Feeding Practices And Children’S Intakes Of Fruit, Vegetables And Confectionary/Sugar-Sweetened Beverages, Carolina Bassu, Clare Corish, John Kearney

Articles

Within the home environment, parents influence their children’s dietary intakes through their parenting and dietary practices, and the foods they make available/accessible. The aim of this cross-sectional study was to examine the associations between home environmental characteristics and children’s dietary intakes. Three hundred and thirty-two children aged three–five years and their parents participated in the study. Home environmental characteristics, including parental control feeding practices, were explored using validated and standardized questionnaires such as the Child Feeding Questionnaire (CFQ), the Physical and Nutritional Home Environment Inventory (PNHEI) and the Healthy Home Survey (HHS). Parent and child food consumption was also measured. …

Atmospheric Biodetection Part I: Study Of Airborne Bacterial Concentrations From January 2018 To May 2020 At Saclay, France, Roland Sarda-Estève, Dominique Baisnée, Benjamin Guinot, Gediminas Maineli, John Sodeau, David O'Connor, Jean Pierre Besancenot, Michel Thibaudon, Sara Monteiro, Jean-Eudes Petit, Valérie Gros

Articles

Background: The monitoring of bioaerosol concentrations in the air is a relevant endeavor due to potential health risks associated with exposure to such particles and in the understanding of their role in climate. In this context, the atmospheric concentrations of bacteria were measured from January 2018 to May 2020 at Saclay, France. The aim of the study was to understand the seasonality, the daily variability, and to identify the geographical origin of airborne bacteria. Methods: 880 samples were collected daily on polycarbonate filters, extracted with purified water, and analyzed using the cultivable method and flow cytometry. A source receptor model …

Extraction Of Protein From Four Different Seaweeds Using Three Different Physical Pre-Treatment Strategies, Jack O'Connor, Steve Meaney, Gwilym A. Williams, Maria Hayes

Articles

Seaweeds are a rich source of protein and can contain up to 47% on the dry weight basis. It ischallenging to extract proteins from the raw biomass of seaweed due to resilient cell-wall complexes.Four species of macroalgae were used in this study-two brown,Fucus vesiculosusandAlaria esculenta,and two red,Palmaria palmataandChondrus crispus. Three treatments were applied individually tothe macroalgal species: (I) high-pressure processing (HPP); (II) laboratory autoclave processing and(III) a classical sonication and salting out method. The protein, ash and lipid contents of the resultingextracts were estimated. Yields of protein recovered ranged from 3.2% forFucus vesiculosuspre-treatedwith high pressure processing to 28.9% protein recovered …

Synthesis And Optimisation Of P3 Substituted Vinyl Sulfone-Based Inhibitors As Anti-Trypanosomal Agents, William Doherty, Nikoletta Adler, Andrew Knox, Thomas J. Butler, Paul Evans

Articles

A series of lysine-based vinyl sulfone peptidomimetics were synthesised and evaluated for anti-trypanosomal activity against bloodstream forms of T. brucei. This focused set of compounds, varying in the P3 position, were accessed in a divergent manner from a common intermediate (ammonium salt 8). Several P3 analogues exhibited sub-micromolar EC50 values, with thiourea 14, urea 15 and amide 21 representing the most potent anti-trypanosomal derivatives of the series. In order to establish an in vitro selectivity index the most active anti-trypanosomal compounds were also assessed for their impact on cell viability and cytotoxity effects in mammalian cells. Encouragingly, all compounds only …

Optimisation Of Estrogen Receptor Subtype-Selectivity Of A 4-Aryl-4h-Chromene Scaffold Previously Identified By Virtual Screening, Miriam Carr, Andrew Knox, Daniel Nevin, Niamh O'Boyle, Shu Wang, Billy Egan, Thomas Mccabe, Brendan Twamley, Daniela Zisterer, David Lloyd, Mary Meegan

Articles

4-Aryl-4H-Chromene derivatives have been previously shown to exhibit anti-proliferative, apoptotic and anti-angiogenic activity in a variety of tumor models in vitro and in vivo generally via activation of caspases through inhibition of tubulin polymerisation. We have previously identified by Virtual Screening (VS) a 4-aryl-4H-chromene scaffold, of which two examples were shown to bind Estrogen Receptor α and β with low nanomolar affinity and <20-fold selectivity for α over β and low micromolar anti-proliferative activity in the MCF-7 cell line. Thus, using the 4-aryl-4H-chromene scaffold as a starting point, a series of compounds with a range of basic arylethers at C-4 and modifications at the C3-ester substituent of the benzopyran ring were synthesised, producing some potent ER antagonists in the MCF-7 cell line which were highly selective for ERα (compound 35; 350-fold selectivity) or ERβ (compound 42; 170-fold selectivity).

Late Pregnancy Vitamin D Deficiency Is Associated With Doubled Odds Of Birth Asphyxia And Emergency Caesarean Section: A Prospective Cohort Study, Hanna Augustin Olausson, Sinead Mulcahy, Inez Schoenmakers,, Maria Bullarbo, Anna Glantz, Anna Winkvist, Linnea Bärebring

Articles

The aim of this prospective cohort study was to investigate the associations between maternal vitamin D status in late pregnancy and emergency caesarean section (EMCS) and birth asphyxia, in a population based sample of women in Sweden.

Pre-Clinical Models Of Small Cell Lung Cancer And The Validation Of Therapeutic Targets, Jane S.Y. Sui, Petra Martin, Steven G. Gray

Articles

Introduction: Small-cell lung cancer (SCLC) is an aggressive form of lung cancer that has a dismal prognosis. One of the factors hindering therapeutic developments for SCLC is that most SCLC is not surgically resected resulting in a paucity of material for analysis. To address this, significant efforts have been made by investigators to develop pre-clinical models of SCLC allowing for downstream target identification in this difficult to treat cancer.

Areas covered: In this review, we describe the current pre-clinical models that have been developed to interrogate SCLC, and outline the benefits and limitations associated with each. Using examples …

The Prevalence Of Overweight And Obesity In Irish Children Between 1990 And 2019, Aisling O'Donnell, Maria Buffini, Laura Kehoe, Ann Nugent, John Kearney, Janette Walton, Albert Flynn, Breige Mcnulty

Articles

Objective: The present study aimed to examine the temporal prevalence of overweight and obesity in Irish children through different methodologies and evaluate the change in rates between 1990 and 2019.

An Ammonia Sensor Using An Unadorned Bromocresol Layer, John Cassidy, Caoimhe Ní Néill, Merve Akdağ, Tony Betts

Articles

Bromocresol Purple,(BCP) cast onto an acetate sheet, was used to sense ammonia. This simple layer responded reversibly to a low concentration ( 15 ppm) of ammonia in the presence of water vapour. The BCP solution was spincoated on an acetate sheet from a solution in dichloromethane. This layer was exposed to nitrogen and NH3/H2O vapour in quick succession. The colour change occurred from yellow to purple rapidly in the solid state. The λmax for the neutral ( acid) form of the BCP was found to be 435 nm and the λmax for the dianion ( base form) of the BCP …

Introducing A Model And A Framework To Unify The Pharmaceutical Quality System Enablers Quality Risk Management & Knowledge Management, Martin J. Lipa, Kevin O'Donnell, Anne Greene

Articles

An organization that effectively manages knowledge should be able to recognize and proactively apply new learnings to better anticipate risks. This is particularly important in the manufacture of medicinal products. Since the publication of ICH Q10 in 2010, Quality Risk Management (QRM) and Knowledge Management (KM) have been positioned as co-enablers to the Pharmaceutical Quality System. The authors of this paper present a Knowledge Management process model to foster greater practical understanding of the practice of knowledge management. This model when joined with the familiar ICH Q9 process model for QRM, should enable a company to better manage their knowledge …

Phenology Of Cupressaceae Urban Infrastructure Related To Its Pollen Content And Meteorological Variables, A. Monroy-Colín, J. M. Maya-Manzano, I. Silva-Palacios, R. Tormo-Molina, R. Pecero-Casimiro, Á. Gonzalo-Garijo, S. Fernández-Rodríguez

Articles

Cupressaceae pollen is one of the major airborne allergens of the Mediterranean region and in other regions around the world. Pollen production of these species causes considerable allergic problems during winter, being this type of pollen the most abundant in this period of the year. This work aims to relate phenology, meteorology and airborne pollen records in these species. Aerobiological sampling was carried out in Badajoz (SW Spain) from 2016 to 2018 using Hirst-type volumetric sampler. Pollination phenology was studied in 50 specimens, ten of Cupressus macrocarpa, ten of Cupressus arizonica, 15 of Cupressus sempervirens and 15 of …

Tracing Sources Of Natural Organic Matter, Trihalomethanes And Metals In Groundwater From A Karst Region, Connie O'Driscoll, Eoin Mcgillicuddy, Peter Croot, Pamela Bartley, John Mcmyler, Jerome Sheahan, Liam Morrison

Articles

Groundwater offers an important source for drinking water around the world; however, groundwater quality is under increasing pressure and is particularly vulnerable in karst areas. Total organic carbon (TOC) is significantly related to groundwater quality and when not removed by water treatment processes can give rise to the formation of disinfection by-products trihalomethanes (THMs) above the level of compliance. This study investigated the source of organic matter giving rise to the THM exceedances in a groundwater supply in a karst area. Results highlighted that source water for this groundwater supply was prone to surface water infiltration linked to rainfall events; …

Smartphone Use As A Possible Risk Factor For Myopia, Saoirse Mccrann, James Loughman, John Butler, Nabin Paudel, Daniel Ian Flitcroft

Articles

Clinical Relevance

This study demonstrates an association between myopia and smartphone data usage. Youths now spend more time participating in near tasks as a result of smartphone usage. This poses an additional risk factor for myopia development/progression and is an important research question in relation to potential myopia management strategies.

Background

Children are now exposed to another possible environmental risk factor for myopia-smartphones. This study investigates the amount of time students spend on their smartphones and their pattern of smartphone usage from a myopia perspective.

Methods

Primary, secondary and third-level students completed a questionnaire exploring patterns of smartphone usage and …

Flash Vep In Clinically Stable Pre-Term And Full-Term Infants, Anish Kharal, Safal Khanal, Jyoti Baba Shrestha, Gauri Shankar Shrestha, Nabin Paudel

Articles

Purpose

Pre-term infants are at risk of abnormal visual development that can range from subtle to severe. The aim of this study was to compare flash VEPs in clinically stable pre-term and full-term infants at 6 months of age.

Methods

Twenty-five pre-term and 25 full-term infants underwent flash VEP testing at the age of 6 months. Monocular VEPs were recorded using flash goggles on a RETIscan system under normal sleeping conditions. Amplitude and peak time responses of the P2 component in the two eyes were averaged and compared between the two groups. Multiple regression analyses were performed to assess the …

Empirical Study On The Effects Of Acquisition Parameters For Ftir Hyperspectral Imaging Of Brain Tissue, David Perezguaita, Julia Sacharz, Mustafa Kasniz, Shaiju Nazeer, Bayden Wood, Philip Heraud

Articles

Fourier transform infrared (FTIR) spectroscopic imaging is a powerful technique for molecular imaging of pathologies associated with the nervous systems including multiple sclerosis research. However, there is no standard methodology or standardized protocol for FTIR imaging of tissue sections that maximize the ability to discriminate between the molecular, white and granular layers, which is essential in the investigation of the mechanism of demyelination process. Tissue sections are heterogeneous, complex and delicate, hence the parameters to generate high quality images in minimal time becomes essential in the modern clinical laboratory. This article presents an FTIR spectroscopic imaging study of post-mortem human …

Discriminant Analysis And Feature Selection In Mass Spectrometry Imaging Using Constrained Repeated Random Sampling - Cross Validation (Corrs-Cv), David Perezguaita, Julia Kuligowsky, Guillermo Quintas

Articles

No abstract provided.

Towards A Rapid Screening Of Liver Grafts At The Operating Room Using Mid-Infrared Spectroscopy, David Perezguaita, Marta Moreno Torres, Ramiro Jover, Eugenia Pareja, Bernard Lendl, Julia Kuligowsky, Guillermo Quintas

Articles

The estimation of steatosis in a liver graft is mandatory prior to liver transplantation, as the risk of graft failure increases with the level of infiltrated fat. However, the assessment of liver steatosis before transplantation is typically based on a qualitative or semiquantitative characterization by visual inspection and palpation and histological analysis. Thus, there is an unmet need for transplantation surgeons to have access to a diagnostic tool enabling an in situ fast classification of grafts prior to extraction. In this study, we have assessed an attenuated total reflection−Fourier transform infrared (ATR−FTIR) spectroscopic method compatible with the requirements of an …

A Vibrational Spectroscopic Based Approach For Diagnosing Babesia Bovis Infection, Anja Ruther, David Perezguaita, William Poole, Brian Cooke, Carlos Suarez, Philip Heraud, Bayden Wood

Articles

Babesia bovis parasites present a serious and significant health concern for the beef and dairy industries in many parts of the world. Difficulties associated with the current diagnostic techniques include they are prone to human error (microscopy) or expensive and time consuming (Polymerase Chain Reaction) to perform. Little is known about the biochemical changes in blood that are associated with Babesia infections. The discovery of new biomarkers will lead to improved diagnostic outcomes for the cattle industry. Vibrational spectroscopic technologies can record a chemical snapshot of the entire organism and the surrounding cell thereby providing a phenotype of the organism …

The Antibacterial And Anti-Biofilm Activity Of Metal Complexes Incorporating 3,6,9- Trioxaundecanedioate And 1,10-Phenanthroline Ligands In Clinical Isolates Of Pseudomonas Aeruginosa From Irish Cystic Fibrosis Patients, Megan O'Shaughnessy, Pauraic Mccarron, Livia Viganor, Malachy Mccann, Michael Devereux, Orla L. Howe

Articles

Chronic infections of Pseudomonas aeruginosa in the lungs of cystic fibrosis (CF) patients are problematic in Ireland where inherited CF is prevalent. The bacteria's capacity to form a biofilm in its pathogenesis is highly virulent and leads to decreased susceptibility to most antibiotic treatments. Herein, we present the activity profiles of the Cu(II), Mn(II) and Ag(I) tdda-phen chelate complexes {[Cu(3,6,9-tdda)(phen)2].3H2O.EtOH}n (Cu-tdda-phen), {[Mn(3,6,9-tdda)(phen)2].3H2O.EtOH}n (Mn-tdda-phen) and [Ag2(3,6,9-tdda)(phen)4].EtOH (Ag-tdda-phen) (tddaH2 = 3,6,9-trioxaundecanedioic acid; phen = 1,10-phenanthroline) towards clinical isolates of P. aeruginosa derived from Irish CF patients in comparison to two reference laboratory strains (ATCC 27853 and PAO1). The effects of the metal-tdda-phen …

Prevalence Of Colour Vision Deficiency In The Republic Of Ireland Schoolchildren And Associated Socio-Demographic Factors, Síofra Harrington, Peter Davison, Veronica O'Dwyer

Articles

Clinical relevance: Early screening is essential to counsel schoolchildren with congenital colour vision deficiency (CVD) in determining their future career path and to advise teachers of the impact of CVD on classroom difficulties.

Background: Congenital CVD is an X-linked genetic abnormality relatively commonplace in humans. This study aimed to determine the prevalence of congenital CVD in the Republic of Ireland schoolchildren and associated socio-demographic factors.

Methods: A total of 1,626 schoolchildren (882 boys and 744 girls), in two age groups (728 aged 6–7 years and 898 aged 12–13 years) were examined from randomly selected schools. Colour vision …

The Efficacy Of Warm Compresses In The Treatment Of Meibomian Gland Dysfunction And Demodex Folliculorum Blepharitis, Orla Murphy, Veronica O'Dwyer, Aoife Lloyd-Mckernan

Articles

Purpose: To investigate and compare the effect of warm compresses on meibomian gland dysfunction and Demodex folliculorum blepharitis.

Methods: Forty-two subjects (13 males, 29 females; mean age of 56.45 years) enrolled and completed the two-month warm compress treatment study. Three warm compress therapies were compared: Warm face cloth, MGDRx EyeBag® and OPTASETM Moist Heat Mask. Subjects attended for four visits: baseline, two weeks, four weeks, and eight weeks. Subjective symptoms, osmolarity, non-invasive tear break-up time, ocular surface staining, Schirmer I test, meibum expressibility and clarity, and eyelash manipulation and epilation to assess for the presence of Demodex folliculorum, …

Phenotypic And Functional Characteristics Of Exosomes Derived From Irradiated Mouse Organs And Their Role In The Mechanisms Driving Non-Targeted Effects, Seda Tuncay Cagatay, Ammar Mayah, Mariateresa Mancuso, Paola Giardullo, Simonetta Pazzaglia, Anna Saran, Amuthachelvi Daniel, Damian Traynor, Aidan Meade, Fiona Lyng, Soile Tapio Tapio, Munira Kadhim Munira Kadhim

Articles

No abstract provided.

Projections Of Excess Mortality Related To Diurnal Temperature Range Under Climate Change Scenarios: A Multi-Country Modelling Study, Whanhee Lee, Yoonhee Kim Yoonhee Kim, Francesco Sera, Antonio Gasparrini, Rokjin Park Rokjin Park, Hayon Michelle Choi, Kristi Prifti, Michelle L. Bell, Rosana Abrutzky Rosana Abrutzky, Yuming Guo Yuming Guo, Shilu Tong Shilu Tong, Micheline De Sousa Zanotti Stagliorio Coelho, Paulo Hilario Nascimento Saldiva, Eric Lavigne, Hans Orru, Ene Indermitte, Jouni J K Jaakkola, Niilo R I Ryti, Mathilde Pascal Mathilde Pascal, Patrick J. Goodman, Ariana Zeka, Masahiro Hashizume Masahiro Hashizume, Yasushi Honda, Magali Hurtado Diaz, Julio César Cruz Julio César Cruz, Ala Overcenco, Baltazar Nunes, Joana Madureira, Noah Scovronick, Fiorella Acquaotta, Aurelio Tobias, Ana Maria Vicedo-Cabrera Ana Maria Vicedo-Cabrera, Martina S. Ragettli, Yue-Liang Leon Guo, Bing-Yu Chen, Shanshan Li, Ben Armstrong, Antonella Zanobetti, Joel Schwartz, Ho Kim

Articles

Various retrospective studies have reported on the increase of mortality risk due to higher diurnal temperature range (DTR). This study projects the effect of DTR on future mortality across 445 communities in 20 countries and regions.