Digital Commons Network^™

Infrared Based Saliva Screening Test For Covid-19, Bayden R. Wood, Kamila Kochan, Diana E. Bedolla, Natalia Salazar‐Quiroz, Samantha L. Grimley, David Perezguaita, Matthew J. Baker, Jitraporn Vongsvivut, Mark J. Tobin, Keith R. Bambery, Dale Christensen, Shivani Pasricha, Anthony K. Eden, Aaron Mclean

Articles

Abstract: Severe acute respiratory syndrome coronavirus 2 has resulted in an unprecedented need for diagnostic testing that is critical in controlling the spread of COVID-19. We propose a portable infrared spectrometer with purpose-built transflection accessory for rapid point-of-care detection of COVID-19 markers in saliva. Initially, purified virion particles were characterized with Raman spectroscopy, synchrotron infrared (IR) and AFM-IR. A data set comprising 171 transflection infrared spectra from 29 patients testing positive for SARS-CoV-2 by RT-qPCR and 28 testing negative, was modeled using Monte Carlo Double Cross Validation with 50 randomized test and model sets. The testing sensitivity was 93 % …

From Bench To Worktop: Rapid Evaluation Of Nutritional Parameters In Liquid Foodstuffs By Ir Spectroscopy, David Perezguaita

Articles

We evaluated the use of attenuated total reflectance infrared spectroscopy for simultaneous in situ quantification of the nutritional composition of liquid food stuffs in the industrial kitchen context. Different methodologies were compared, including dry and wet acquisition along with instrument parameters and measurement times of 4 and 60 s. The most effective technique was 1-minute measurement, with prediction errors of 2.6, 0.7, 1.0, 2.2, 0.8, 2.4 g/100 mL and 150 Kcal, for carbohydrates, proteins, fat, sugars, saturated fat, water and energy values, respectively.The 4-second method resulted in larger errors but was more applicable for inline measurements. Dry measurements successfully predicted …

Ice-Breaking Fleets Of The United States And Canada : Assessing The Current State Of Affairs And Future Plans, Megan Drewniak, Dimitrios Dalaklis, Anastasia Christodoulou, Rebecca Sheehan

Articles

In recent years, a continuous decline of ice-coverage in the Arctic has been recorded, but these high latitudes are still dominated by earth’s polar ice cap. Therefore, safe and sustainable shipping operations in this still frozen region have as a precondition the availability of ice-breaking support. The analysis in hand provides an assessment of the United States’ and Canada’s polar ice-breaking program with the purpose of examining to what extent these countries’ relevant resources are able to meet the facilitated growth of industrial interests in the High North. This assessment will specifically focus on the maritime transportation sector along the …

Perspectives On Cyber Security For Offshore Oil And Gas Assets, Iosif Progoulakis, Nikitas Nikitakos, Paul Rohmeyer, Barry Bunin, Dimitrios Dalaklis, Stavros Karamperidis

Articles

In an ever-evolving technological industry, the oil and gas sector is already moving forward through the adaptation of Industry 4.0 and the adaptation of advanced cyber technologies through Oil and Gas 4.0. As IT/OT (information technology/operational technology) systems are evolving technologically, so are the cyber security threats faced by the offshore oil and gas assets. This paper aims to raise the awareness of cyber security threats and the organizational and technical measures that need to be adopted by the oil and gas industry for remote and complex assets in the upstream sector. A comprehensive literature review covering the areas of …

Perspectives On Cyber Security For Offshore Oil And Gas Assets, Iosif Progoulakis, Nikitas Nikitakos, Paul Rohmeyer, Barry Bunin, Dimitrios Dalaklis, Stavros Karamperidis

Articles

In an ever-evolving technological industry, the oil and gas sector is already moving forward through the adaptation of Industry 4.0 and the adaptation of advanced cyber technologies through Oil and Gas 4.0. As IT/OT (information technology/operational technology) systems are evolving technologically, so are the cyber security threats faced by the offshore oil and gas assets. This paper aims to raise the awareness of cyber security threats and the organizational and technical measures that need to be adopted by the oil and gas industry for remote and complex assets in the upstream sector. A comprehensive literature review covering the areas of …

The Northwest Passage In The Arctic : A Brief Assessment Of The Relevant Marine Transportation System And Current Availability Of Search And Rescue Services, Rebecca Sheehan, Dimitrios Dalaklis, Anastasia Christodoulou, Megan Drewniak, Peter Raneri, Angelos Dalaklis

Articles

No abstract provided.

Liquefied Natural Gas As Ship Fuel : A Maltese Regulatory Gap Analysis, Mark Philip Cassar, Dimitrios Dalaklis, Fabio Ballini, Seyedvahid Vakili

Articles

With water covering almost three-quarters of the Earth’s surface and by factoring in that the maritime transport industry is holding a comparative advantage in relation to all other means, activities associated with the seas and oceans of our planet are extremely vital for a normal functioning of global trade. Furthermore, evaluating the opportunities of the so-called “Blue Economy” and possibilities for further growth should be at the epicentre of future development plans. Indicative examples - apart from various endeavours of maritime transport - include other sectors, like shipbuilding and repairs, fishing activities and related processes, as well as oil and …

Parents' Experiences Of A Language-Focused Home Visiting Scheme In Ireland, Aisling Ni Dhiorbhain Dr, Maire Mhic Mhathuna, Padraig Ó Duibhir Dr

Articles

This article reports parents’ experiences of the Tús Maith (Good Start) home visiting scheme in South-West Ireland. The goal of Tús Maith is to support parents who wish to speak Irish to their children at home in the Kerry Gaeltacht, an Irish-speaking heartland area. Home visitors spend an hour a week, over a period of six weeks, interacting with children and parents with varying levels of competency in Irish. Home visitors who are native speakers of Irish, offer individualised guidance on how to promote the use of Irish as a home language, while encouraging families to engage in activities …

Thoughts On The Future Of Higher Education In The Uk: A Personal View With A Historical Context, Jonathan Blackledge

Articles

Before the effect of the COVID-19 Pandemic, there had been continued debate about the future of Higher Education (HE) in the UK. It is now accepted that the effect of the pandemic will have a long-lasting effect on HE in the UK and elsewhere. This paper addresses the changes that are currently taking place, based on a strategy that aims to develop a future knowledge-based economy, following the UK governments 2019 landmark review of HE. It explores the underlying parallels between the current situation and certain historical events that catalysed the development of a new approach to HE in the …

Using Case Studies In Engineering Ethics Education: The Case For Immersive Scenarios Through Stakeholder Engagement And Real Life Data, Diana Adela Martin, Eddie Conlon, Brian Bowe

Articles

Our contribution is part of a broader study conducted in cooperation with the national accreditation body Engineers Ireland that examined the conceptualisation and education of ethics in engineering programmes in Ireland. The paper is a qualitative examination of the use of case studies in engineering ethics education and includes 23 engineering programmes from 6 higher education institutions in Ireland. The qualitative study aims to determine (RQ1) how cases are selected, (RQ2) the goals envisioned for engineering ethics case instruction, (RQ3) the characteristics of the scenarios employed and (RQ4) the preferred application by instructors. A first finding notes the diverse set …

How To Promote Exclusive Breastfeeding In Ireland: A Qualitative Study On Views Of Chinese Immigrant Mothers, Haoyue Chen, Qianling Zhou, Tanya M. Cassidy, Katherine Younger, Siao Shen, John M. Kearney

Articles

Background The exclusive breastfeeding rate in Ireland is very low with extremely slow annual growth.The population of immigrants in Ireland is increasing. Improving exclusive breastfeeding practice amongimmigrants may contribute to the overall improvement of exclusive breastfeeding rates in Ireland. Thisstudy was conducted to elicit recommendations on improving exclusive breastfeeding rate for six monthsamong Chinese immigrants in Ireland. Methods Fourteen semi-structured in-depth individual interviewswere conducted with Chinese immigrant mothers resident in Ireland, who breastfed exclusively for four to six months.

Emerging Avenues Immunotherapy For The Management Of Malignant Pleural Mesothelioma, Steven G. Gray

Articles

Background: The role of immunotherapy in cancer is now well-established, and therapeutic options such as checkpoint inhibitors are increasingly being approved in many cancers such as non-small cell lung cancer (NSCLC). Malignant pleural mesothelioma (MPM) is a rare orphan disease associated with prior exposure to asbestos, with a dismal prognosis. Evidence from clinical trials of checkpoint inhibitors in this rare disease, suggest that such therapies may play a role as a treatment option for a proportion of patients with this cancer. Main text: While the majority of studies currently focus on the established checkpoint inhibitors (CTLA4 and PD1/ PDL1), there …

Application Of Plasma Technology In Bioscience And Biomedicine, Daniela Boehm, Christina Canal

Articles

Plasma technology has been an integral part of research in life sciences for decades through its role in the manufacture and modification of material surface characteristics of many common laboratory consumables, and it is still of interest in many fields, including the treatment of biomaterials and implants. In recent years, the use of plasma at room temperature and atmospheric pressure (cold atmospheric plasma) has led to a shift in the field by putting the focus on biomedicine due to its applicability to heat-sensitive materials, including biomaterials, and expanding the traditional applicability of plasmas to cells and tissues. Consequently, biomedical applications …

Doctors Can’T Be Doctors All Of The Time’: A Qualitative Study Of How General Practitioners And Medical Students Negotiate Public-Professional And Private-Personal Realms Using Social Media, Megan Marshal

Articles

Objective The objective of this study is to explore the experiences and perspectives of general practitioners’ and medical students’ use of, and behaviour on, social media and to understand how they negotiate threats to professional and personal life on social media. Design A two-phase qualitative design was used, consisting of semistructured interviews and follow-up vignettes, where participants were asked to respond to vignettes that involved varying degrees of unprofessional behaviour. Data were analysed using template analysis. Setting and participants Participants were general practitioner tutors and third year medical students who had just completed placement on the University of Limerick longitudinal …

Antiracism, Reflection, And Professional Identity, Monte Mills, Eduardo R.C. Capulong, Andrew King-Ries

Articles

Intent on more systematically developing the emerging professional identities of law students, the professional identity formation movement is recasting how we think about legal education. Notably, however, the movement overlooks the structural racism imbedded in American law and legal education. While current models of professional development value diversity and cross-cultural competence, they do not adequately prepare the next generation of legal professionals to engage in the sustained work of interrupting and overthrowing race and racism in the legal profession and system. This article argues that antiracism is essential to the profession’s responsibility to serve justice and therefore key to legal …

Taxing Parents: Welfarist Theories, Shannon Weeks Mccormack

Articles

The Internal Revenue Code (the “Code”) taxes parents inequitably. Couples with a sole earner are under-taxed compared to couples with dual earners or single parents. Previous scholarship has identified these inequities and then argued that this sole earner bias should be eliminated. These arguments, however, have often been incomplete. Simply establishing that an inequity exists does not create a full argument for legal reform. After all, the Code plays favorites all the time. Scholars have traditionally turned to theories of distributive justice when evaluating whether tax preferences are warranted. These theories offer competing visions about the way resources should be …

Protecting Patients From Physicians Who Inflict Harm: New Legal Resources For State Medical Boards, Elizabeth Pendo, Tristan Mcintosh, Heidi A. Walsh, Kari Baldwin, James M. Dubois

Articles

State medical boards (SMBs) protect the public by ensuring that physicians uphold appropriate standards of care and ethical practice. Despite this clear purpose, egregious types of wrongdoing by physicians are alarmingly frequent, harmful, and under-reported. Even when egregious wrongdoing is reported to SMBs, it is unclear why SMBs sometimes fail to promptly remove seriously offending physicians from practice. Legal and policy tools that are targeted, well-informed, and actionable are urgently needed to help SMBs more effectively protect patients from egregious wrongdoing by physicians.

Past reviews of SMB performance have identified features of SMBs associated with higher rates of severe disciplinary …

The Right To Benefit From Big Data As A Public Resource, Mary D. Fan

Articles

The information that we reveal from interactions online and with electronic devices has massive value—for both private profit and public benefit, such as improving health, safety, and even commute times. Who owns the lucrative big data that we generate through the everyday necessity of interacting with technology? Calls for legal regulation regarding how companies use our data have spurred laws and proposals framed by the predominant lens of individual privacy and the right to control and delete data about oneself. By focusing on individual control over droplets of personal data, the major consumer privacy regimes overlook the important question of …

Advisors Or Enablers? Bringing Professional Service Providers Into The Guiding Principles’ Fold, Anita Ramasastry

Articles

After a decade, different businesses adhere to the UN Guiding Principles on Business and Human Rights (UNGPs). Some key commercial entities, however, remain largely outside of the UNGPs universe, including professional service providers (PSPs) who are retained by businesses to provide  expert advice and services. These advisors include lawyers, management consultants, architects and others. Some may have specialized units that provide advice on the UNGPs when retained solely for that purpose. But when asked to provide general commercial legal advice, to design a building, or restructure a business, such advisors do not typically appear to apply the UNGPs, to identify …

An Assessment Of Contamination Fingerprinting Techniques For Determining The Impact Of Domestic Wastewater Treatment Systems On Private Well Supplies, Chris Fennell, Bruce Misstear, David O'Connell, Donata Dubber, Patrice Behan, Martin Danaher, Mary Moloney, Laurence Gill

Articles

Private wells in Ireland and elsewhere have been shown to be prone to microbial contamination with the main suspected sources being practices associated with agriculture and domestic wastewater treatment systems (DWWTS). While the microbial quality of private well water is commonly assessed using faecal indicator bacteria, such as Escherichia coli, such organisms are not usually source-specific, and hence cannot definitively conclude the exact origin of the contamination. This research assessed a range of different chemical contamination fingerprinting techniques (ionic ratios, artificial sweeteners, caffeine, fluorescent whitening compounds, faecal sterol profiles and pharmaceuticals) as to their use to apportion contamination of private …

In Silico And In Vitro Screening For Potential Anticancer Candidates Targeting Gpr120, Ajay Pal, James Curtin, Gemma K. Kinsella

Articles

The G-protein coupled receptor - GPR120 has recently been implicated as a novel target for colorectal cancer (CRC) and other cancer managements. In this study, a homology model of GPR120S (short isoform) was generated to identify potential anti-cancer compounds targeting the GPR120 receptor using a combined in silico docking-based virtual screening (DBVS), structure-activity relationships (SAR) and in vitro screening approach. SPECS database of synthetic chemical compounds (~350,000) was screened using the developed GPR120S model to identify molecules binding to the orthosteric binding pocket followed by an AutoDock SMINA rigid-flexible docking protocol. The best 13 hit molecules were then tested in …

Seaweed Polysaccharide In Food Contact Materials (Active Packaging, Intelligent Packaging, Edible Films, And Coatings), Kalpani Perera, Shubham Sharma, Dileswar Pradhan, Amit Jaiswal, Swarna Jaiswal

Articles

Food contact materials (FCMs) are materials that come in contact with food products such as food packaging which play a significant role in food quality and safety. Plastic, which is a major food packaging material, harms the ecosystem, wildlife, and the environment. As a result, numerous researches have been in progress on alternative polymers, which have similar properties as plastic but are also environmentally friendly (biodegradable). In recent years, the utilization of seaweed polysaccharides has piqued interest due to their biodegradability, non-toxicity, antioxidant capabilities, and excellent film formation ability. However, it has a number of drawbacks such as low tensile …

Seaweeds Polysaccharides In Active Food Packaging: A Review Of Recent Progress, Carina Dietz, Shubham Sharma, Amit Jaiswal, Swarna Jaiswal

Articles

Background

Due to its short lifetime, food packaging leads to a rapid accumulation of plastic in our surroundings and thereby also has a huge impact on environmental pollution. To reduce these effects and create a more sustainable approach towards food packaging, biodegradable and biobased polymers have been developed and are emerging on the market.

Scope and approach

This review provides the current state of research regarding active packaging and the incorporation of seaweed into food packaging. Further, it summarises the resulting consequences of the seaweed incorporation on mechanical, physical, thermal, antioxidant, antimicrobial, and chemical properties, as well as the release …

Structure Based Prediction Of A Novel Gpr120 Antagonist Based On Pharmacophore Screening And Molecular Dynamics Simulations, Ajay Pal Mr, Gemma K. Kinsella, James Curtin

Articles

The G-protein coupled receptor, GPR120, has ubiquitous expression and multifaceted roles in modulating metabolic and anti-inflammatory processes. Recent implications of its role in cancer progression have presented GPR120 as an attractive oncogenic drug target. GPR120 gene knockdown in breast cancer studies revealed a role of GPR120-induced chemoresistance in epirubicin and cisplatin-induced DNA damage in tumour cells. Higher expression and activation levels of GPR120 is also reported to promote tumour angiogenesis and cell migration in colorectal cancer. Some agonists targeting GPR120 have been reported, such as TUG891 and Compound39, but to date development of small-molecule inhibitors of GPR120 is limited. …

Ursolic Acid Inhibits Collective Cell Migration And Promotes Jnk-Dependent Lysosomal Associated Cell Death In Gioblastoma Multiforme Cells, Gillian Conway, Diamante Zizyte, Julie Mondala, Zhonglei He, Lorna Lynam, Mathilde Lecourt, Orla L. Howe, James Curtin

Articles

Ursolic acid (UA) is a bioactive compound which has demonstrated therapeutic efficacy in a variety of cancer cell lines. UA activates various signalling pathways in Glioblastoma multiforme (GBM) and offers a promising starting point in drug discovery; however, understanding the relationship between cell death and migration has yet to be elucidated. UA induces a dose dependent cytotoxic response demonstrated by flow cytometry and biochemical cytotoxicity assays. Inhibitor and fluorescent probe studies demonstrate that UA induces a caspase independent, JNK dependent, mechanism of cell death. Migration studies established that UA inhibits GBM collective cell migration in a time dependent manner that …

Fruits And Vegetables In The Management Of Underlying Conditions For Covid-19 High-Risk Groups, Nora Moreb, Ahmed Albandary, Swarna Jaiswal, Amit Jaiswal

Articles

: SARS-CoV-2 or COVID-19 is a novel coronavirus, which is the cause of the current pandemic with 107,411,561 infections and 2,351,195 death worldwide so far. There are multiple symptoms that are linked with the infection of COVID-19 such as coughing, shortness of breath, congestion together with fatigue, fever, loss of taste or smell, headaches, diarrhea, vomiting, and loss of appetite. The lack of or early stage of development of a cure for COVID-19 illness, there is need for insuring the best possible position of health to be able to fight the virus naturally through a robust immune system to limit …

Salmonella, Food Safety And Food Handling Practices, Olugbenga Ehuwa, Amit Jaiswal, Swarna Jaiswal

Articles

: Salmonellosis is the second most reported gastrointestinal disorder in the EU resulting from the consumption of Salmonella-contaminated foods. Symptoms include gastroenteritis, abdominal cramps, bloody diarrhoea, fever, myalgia, headache, nausea and vomiting. In 2018, Salmonella accounted for more than half of the numbers of foodborne outbreak illnesses reported in the EU. Salmonella contamination is mostly associated with produce such as poultry, cattle and their feeds but other products such as dried foods, infant formula, fruit and vegetable products and pets have become important. Efforts aimed at controlling Salmonella are being made. For example, legislation and measures put in place reduced …

Plasma-Treated Water Affects Listeria Monocytogenes Vitality And Biofilm Structure, Oliver Handorf, Viktoria Isabella Pauker, Thomas Weihe, Uta Schnabel, Eric Freund, Sander Bekeschus, Katharina Riedel, Jörg Ehlbeck

Articles

Plasma-generated compounds (PGCs) such as plasma-processed air (PPA) or plasma-treated water (PTW) offer an increasingly important alternative for the treatment of microorganisms in hard-to-reach areas found in several industrial applications including the food industry. To this end, we studied the antimicrobial capacity of plasma-treated water on the vitality and biolm formation of Listeria monocytogenes, a common food spoilage microorganism. Using a microwave plasma (MidiPLexc), 10 ml of deionized water was treated for 100 s, 300 s and 900 s (pretreatment time) and the bacterial biolm was subsequently exposed to the PTW for 1 min, 3 min and 5 min (posttreatment …

A Kitchen At The Heart Of A School–An Investigation Into School Meals In The Republic Of Ireland, Michelle Darmody

Articles

Free school meals provide support to vulnerable families in the Republic of Ireland. Funding is allocated as part of an anti-poverty strategy. An investigation was carried out to discover if the school meal could be used to provide nutritious scratch-cooked food as well as providing opportunities for increased socialisation and pedagogy. Food affects students in a myriad of ways and schools are in a unique position to guide what and how young people eat. This article draws on data from an ethnographic study in an inner city Dublin school.

Comparing Passenger Satisfaction, Employees’ Perspective And Performance On Quality And Safety Indicators: A Field Study, Luca D’Alonzo, Maria Chiara Leva, Edgardo Bucciarelli

Articles

This paper aims to analyze the impact that different attributes related to a Regional Airport service and the socio-economic factors of the passengers have on the passenger’s overall satisfaction. The study also compared passenger and employee satisfaction in relation to the service offered by the airport, to identify possible critical areas of improvement. An Ordinal Logistic Regression (OLR) approach was used to model how the attributes considered for qualifying airport services and the socio-economic variables impact the predicted variable (i.e., passenger satisfaction). Furthermore, the results were triangulated to include quality and safety performance indicators as an objective anchor point for …