Digital Commons Network^™

Adopting Agile Practices When Developing Medical Device Software, Martin Mchugh, Fergal Mccaffery, Garret Coady

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Agile methods are gaining momentum amongst the developers of non-safety critical software. They offer the ability to improve development time, increase quality and reduce development costs. Despite this, the rate of adoption of agile methods within safety critical domains remains low. On face value agile methods appear to be contradictory to regulatory requirements. However while they may appear contradictory, they align on key values such as the development of the highest quality software. To demonstrate that agile methods could in fact be adopted when developing regulatory compliant software they were implemented on a medical device software development project. This implementation …

Peer Victimization And Drd4 Genotype Influence Problem Behaviors In Young Children, Lisabeth Fisher Dilalla, Kyle Bersted, Sufna Gheyara John

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Decades of research supports the presence of significant genetic influences on children’s internalizing (emotional), externalizing (acting out), and social difficulties, including victimization. Additionally, being victimized has been shown to relate to further behavioral problems. The current study assessed the nature of the gene-environment relationships between the DRD4 gene, peer victimization, and externalizing and internalizing difficulties in 6- to 10-year- old children. 174 children (56% girls; 88.6% Caucasian, 3.4% African American, 8% mixed race or Mayan) and their parents were administered victimization and problem behavior questionnaires, and DRD4 was genotyped for the children. An interaction between genes (DRD4) and environment (victimization) …

Visible-Light Activation Of Tio2 Photocatalysts: Advances In Theory And Experiments, Vinodkumar Etacheri, Cristiana Di Valentin, Jenny Schneider, Detlef Bahnemann, Suresh Pillai

Articles

The remarkable achievement by Fujishima and Honda (1972) in the photo-electrochemical water splitting results in the extensive use of TiO2 nanomaterials for environmental purification and energy storage/conversion applications. Though there are many advantages for the TiO2 compared to other semiconductor photocatalysts, its band gap of 3.2 eV restrains application to the UV-region of the electromagnetic spectrum ≤387.5 nm. As a result, development of visible-light active titanium dioxide is one of the key challenges in the field of semiconductor photocatalysis. In this review, advances in the strategies for the visible light activation, origin of visible-light activity, and electronic structure of various …

Leaving The “Big Deal” … Five Years Later, Jonathan Nabe, David Fowler

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Southern Illinois University Carbondale (SIUC) and the University of Oregon each withdrew from several Big Deals with major commercial journal publishers from 2008 to 2010. Analysis of the impact of these decisions was originally conducted and reported in 2011 and 2012. This article provides updated analysis based on interlibrary loan statistics, financial savings, and impact on the collections. Results show that interlibrary loan of lost content still represents a small fraction of prior use, savings have been considerable, and the libraries have been able to address other needs in their collections because of the decision to withdraw.

Answering Halliburton Ii's Unanswered Question: Burdens Of Production And Persuasion On Price Impact At Class Certification, Wendy Gerwick Couture

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No abstract provided.

Constitutional Law, Moral Judgment, And The Supreme Court As Super-Legislature, Brian Leiter

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No abstract provided.

Introduction To Spontaneous Order And Emergence Of New Systems Of Property, Richard A. Epstein

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No abstract provided.

Diary Of A Cataract Surgeon 2045, Claire E. Mcdonnell

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No abstract provided.

Spectroscopic Characterization Of A Radio-Frequency Argon Plasma Jet Discharge In Ambient Air, Patrick J. Cullen, Vladimir Milosavljevic

Articles

This study includes a detailed experimental investigation of the spatial and temporal spectroscopic emission of an argon plasma jet discharge. The study is carried out in ambient air and quenching by inflowing air species is considered. The optical emission spectroscopy of neutral atomic spectral lines and molecular bands, over a range of plasma process parameters, is investigated. Wavelength-resolved argon optical emission profiles are used to monitor the electron energy distribution function and the density of argon metastable atoms. The experimental data indicates that the argon flow rate, in a confined open-air plasma discharge, limits the impact of molecular oxygen in …

Faith In Our Fathers: Can You Believe In Fictional Priests?, Eamon Maher

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I was struck recently by an article that appeared in the online section ofthe Irish Times (November 14th. 2015). Written by a priest called Martin Boland, the piece was prompted by the publication of a novel by John Boyne, A History of Loneliness, which has as its main protagonist Fr Odran Yates, who is forced to live in an Ireland where the priest is more likely to be viewed as a paedophile or pariah than as a respected member of society. Clearly a novelist as disaffected as Boyne admits to being with the Catholic Church, would find it hard to …

Loss Of Foxm1 Results In Reduced Somatotrope Cell Number During Mouse Embryogenesis., Michael J Calderon, Adam G Ploegman, Brock Bailey, Deborah O Jung, Amy M Navratil, Buffy S Ellsworth

Articles

FOXM1, a member of the forkhead box transcription factor family, plays a key role in cell cycling progression by regulating the expression of critical G1/S and G2/M phase transition genes. In vivo studies reveal that Foxm1 null mice have a 91% lethality rate at e18.5 due to significant cardiovascular and hepatic hypoplasia. Thus, FOXM1 has emerged as a key protein regulating mitotic division and cell proliferation necessary for embryogenesis. In the current study, we assess the requirement for Foxm1 in the developing pituitary gland. We find that Foxm1 is expressed in the pituitary at embryonic days 10.5-e18.5 and localizes with …

Marx, Law, Ideology, Legal Positivism, Brian Leiter

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No abstract provided.

Designing Regulatory Experiments, Jennifer Nou

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No abstract provided.

Dirks And The Genesis Of Personal Benefit, Adam C. Pritchard

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In United States v. Newman, the Second Circuit overturned the insider trading convictions of two hedge fund managers who received material nonpublic information from public companies via an extended tipping chain. The Newman court interpreted the Supreme Court's decision in Dirks v. SEC as requiring that the government prove: (1) that the tippee knew that the tipper was disclosing the information in exchange for a personal benefit; and (2) that if the personal benefit does not involve a quid pro quo to the tipper, that the disclosure arise from a "meaningfully close personal relationship" with the recipient of the …

Optimal Choice Of Sample Substrate And Laser Wavelength For Raman Spectroscopic Analysis Of Biological Specimen, Hugh Byrne, Laura Kerr, Bryan M. Hennelly

Articles

Raman spectroscopy is an optical technique based on the inelastic scattering of monochromatic light that can be used to identify

the biomolecular composition of biological cells and tissues. It can be used as both an aid for understanding the etiology

of disease and for accurate clinical diagnostics when combined with multivariate statistical algorithms. This method is nondestructive,potentially non-invasive and can be applied in vitro or in vivo directly or via a fiber optic probe. However, there exists a high degree of variability across experimental protocols, some of which result in large background signals that can often overpower the weak Raman …

A Simple Theory Of Complex Valuation, Anthony Casey, Julia Simon-Kerr

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No abstract provided.

Building A Model Of Tumorigenesis: A Small Group Activity For A Cancer Biology/Cell Biology Course, Leslie Kate Wright

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The multistep nature of tumorigenesis is a foundational concept in the context of Cancer Biology. Many students do not appreciate the complex nature of cancer development nor do they understand how scientists are able to unravel the molecular pathways that lead to tumorigenesis. In this small group activity, students are presented with background information about the multistep nature of tumorigenesis and complete a priming activity that allows them to brainstorm and discuss experimental design. Students are then presented with data from the landmark manuscript, published in 1998 by Vogelstein et al., describing the first pathway of genetic alterations associated …

Why "Live-And-Let-Live" Is Not A Viable Solution To The Difficult Problems Of Religious Accommodation In The Age Of Sexual Civil Rights, Mary Anne Case

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No abstract provided.

How The Ali's Restatement Third Of Property Is Influencing The Law Of Trusts And Estates, Lawrence W. Waggoner

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Restatements, once limited to restating existing law, are now substantially devoted to law reform. The ALI's website states its law-reform policy thus: "The American Law Institute is the leading independent organization in the United States producing scholarly work to clarify, modernize, and otherwise improve the law." In 2014, the Brooklyn Law Review published a symposium issue on Restatements of the Law. A paper in that symposium argued against the ALI's law-reform policy. The authors specifically speculated that the reformist rather than restatist character of the recently completed Restatement (Third) of Property: Wills and Other Donative Transfers (Property Restatement) has "very …

Using Screening And Assessment Evidence Of Trauma In Child Welfare Cases, Frank E. Vandervort

Articles

If you are a child welfare lawyer representing children, parents, or the child welfare agency, understanding how traumatic experiences may impact your clients will help you frame your advocacy. Understanding children and their parents’ histories of exposure to potentially traumatic life events and how those events have impacted the client’s functioning—in school, in interactions with other people, and as parents—can be critical to framing your approach in the case. Evidence of the client’s trauma history and any compromised functioning that may have resulted from that trauma is critical to integrate into your advocacy.

Against Solitary Confinement: Jonah's Redemption And Our Need For Mercy, Margo Schlanger

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Author’s Note: This essay is adapted from one I wrote in September 2013 to give as a d’var Torah for Yom Kippur, and published in Tablet, an online Jewish magazine. Mostly, I’ve added footnotes. As a law professor, I am far more expert at constitutional than biblical exegesis. But perhaps because the Bible and the Constitution share their status as instrumental and highly authoritative documents, my own subjective experience of developing a reading or critique of both has turned out to be remarkably similar. Both exercises require close textual reading and wide-ranging investigation of its extant interpretations; both are informed …

On Mikhailov's Reduction Group, Tihomir Valchev

Articles

We present a generalization of the notion of reduction group which allows one to study in a uniform way certain classes of nonlocal $S$-integrable equations like Ablowitz-Musslimani's nonlocal Schr\"odinger equation. Another aspect of the proposed generalization is the possibility to derive in a systematic way solutions to S-integrable equations with prescribed symmetries.

Raman Micro Spectroscopy For In Vitro Drug Screening: Subcellular Localisation And Interactions Of Doxorubicin, Zeineb Farhane, Franck Bonnier, Alan Casey, Hugh Byrne

Articles

Vibrational spectroscopy, including Raman spectroscopy, has been widely used over the last few years to explore potential biomedical applications. Indeed, Raman spectroscopy has been demonstrated to be a powerful non-invasive tool in cancer diagnosis and monitoring. In confocal microscopic mode, the technique is also a molecularly specific analytical tool with optical resolution which has potential applications in subcellular analysis of biochemical processes, and therefore as an in vitro screening tool of the efficacy and mode of action of, for example, chemotherapeutic agents.

In order to demonstrate and explore the potential in this field, established, model chemotherapeutic agents can be valuable. …

Evaluations Of Refraction Competencies Of Ophthalmic Technicians In Mozambique., James Loughman, Kajal Shah, Kovin Naidoo, Margarida Chagunda

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Purpose: Ophthalmic technicians (OT) work at health facilities in Mozambique and are trained to provide primary and secondary eye care services including basic refraction. This study was designed to assess OT competence and confidence in refraction, and investigate whether an upskilling programme is effective in developing their competence and confidence at refraction. Methods: Thirty-one trainee OTs and 16 qualified OTs were recruited to the study. A background questionnaire was administered to determine the demographic profile of the OTs. A confidence levels questionnaire explored their self-reported skills.

No Good Options: Picking Up The Pieces After King V. Burwell, Nicholas Bagley, David K. Jones

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If the Supreme Court rules against the government in King v. Burwell, insurance subsidies available under the Affordable Care Act (ACA) will evaporate in the thirty-four states that have refused to establish their own health-care exchanges. The pain could be felt within weeks. Without subsidies, an estimated eight or nine million people stand to lose their health coverage. Because sicker people will retain coverage at a much higher rate than healthier people, insurance premiums in the individual market will surge by as much as fifty percent. Policymakers will come under intense pressure to mitigate the fallout from a government loss …

Jewish Games For Learning: Renewing Heritage Traditions In The Digital Age, Owen Gottlieb

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Rather than a discontinuity from traditional modes of learning, new explorations of digital and strategic games in Jewish learning are markedly continuous with ancient practices. An explication of the close connections between traditional modes of Jewish learning, interpretive practice, and gaming culture can help to explain how Jews of the Digital Age can adopt and are adapting modern Games for Learning practices for contemporary purposes. The chapter opens by contextualizing a notion of Jewish Games and the field of Games for Learning. Next, the chapter explains the connections between game systems and Jewish traditions. It closes with a case study …

The Overlooked Benefits Of The Blackstone Principle, Jonathan Masur, John Bronsteen

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No abstract provided.

Low Temperature Electrochemical Deposition Of Highly Active Elements, Daniel Falola, Ian Suni

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Electrochemical methods are attractive for thin film deposition due to their simplicity, conformal and high rate deposition, the ability to easily make multilayers of different composition, ease of scale-up to large surface areas, and applicability to wide variety of different shapes and surface geometries. However, many elements from periodic table of commercial importance are too active to be electrodeposited from aqueous solution. Recent advances are briefly reviewed for room temperature methods for electrochemical deposition, including electrodeposition from ionic liquids, electrodeposition from organic solvents, combined electrodeposition and precipitation on liquid metal cathodes, and galvanic deposition. Recent studies of electrodeposition from ionic …

Multivariate Statistical Methodologies Applied In Biomedical Raman Spectroscopy: Assessing The Validity Of Partial Least Squares Regression Using Simulated Model Datasets., Mark Keating

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Raman spectroscopy is fast becoming a valuable analytical tool in a number of biomedical scenarios, most notably disease diagnostics. Importantly, the technique has also shown increasing promise in the assessment of drug interactions on a cellular and subcellular level, particularly when coupled with multivariate statistical analysis. However, an important consideration, both with Raman spectroscopy and the associated statistical methodologies, is the accuracy of these techniques and more specifically the sensitivities which can be achieved and ultimately the limits of detection of the various methods. The purpose of this study is thus the construction of a model simulated data set with …

Deference Mistakes, Jonathan Masur, Lisa Larrimore Ouellette

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No abstract provided.