Digital Commons Network^™

Structure-Function Relationships Of Archaeal Cbf5 During In Vivo Rna-Guided Pseudouridylation., Mrinmoyee Majumder, Michael S Bosmeny, Ramesh Gupta

Articles

In Eukarya and Archaea, in addition to protein-only pseudouridine (Ψ) synthases, complexes containing one guide RNA and four proteins can also produce Ψ. Cbf5 protein is the Ψ synthase in the complex. Previously, we showed that Ψ's at positions 1940, 1942, and 2605 of Haloferax volcanii 23S rRNA are absent in a cbf5-deleted strain, and a plasmid-borne copy of cbf5 can rescue the synthesis of these Ψ's. Based on published reports of the structure of archaeal Cbf5 complexed with other proteins and RNAs, we identified several potential residues and structures in H. volcanii Cbf5, which were expected to play important …

What’S Wrong With Sentencing Equality?, Richard A. Bierschbach, Stephanos Bibas

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Equality in criminal sentencing often translates into equalizing outcomes and stamping out variations, whether race-based, geographic, or random. This approach conflates the concept of equality with one contestable conception focused on outputs and numbers, not inputs and processes. Racial equality is crucial, but a concern with eliminating racism has hypertrophied well beyond race. Equalizing outcomes seems appealing as a neutral way to dodge contentious substantive policy debates about the purposes of punishment. But it actually privileges deterrence and incapacitation over rehabilitation, subjective elements of retribution, and procedural justice, and it provides little normative guidance for punishment. It also has unintended …

What Remains "Real" About The Law And Literature Movement?: A Global Appraisal, Richard H. Weisberg

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The article explores the enduring relevance and global expansion of the Law and Literature movement, emphasizing its unique contribution to legal discourse by analyzing how narratives reveal the operation of law, the interpretations of legal authorities, and the identifiable causes of legal errors. It argues that literary jurisprudence provides a distinct methodology for understanding jurisprudence, challenging traditional legal scholarship and offering insights into systemic injustices and pathways to justice.

Impediments In The Corporate Social Responsibility (Csr) Space: A Mixed-Method Approach, Tony Kealy

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Despite the potentially positive image and reputation implications of businesses implementing strategies in Corporate Social Responsibility (CSR), there appears to be a dearth of companies willing to play a leading role in moving CSR activities to upper levels within the consciousness of the organisation. The vast majority of businesses are merely complying with national regulations in their business sustainability efforts. This study investigates the reasons why there are road-blocks in the pursuit of higher levels of sustainable business development. A 17-question on-line survey was administered to a number of global participant businesses in a range of industries. The resulting qualitative …

The Second Circuit And Social Justice, Matthew Diller, Alexander A. Reinert

Articles

The Second Circuit is renowned for its landmark rulings in fields such as white collar crime and securities law — bread and butter issues growing out of Wall Street’s preeminence in the financial landscape of the nation. At the same time, the Second Circuit has a long tradition of breaking new ground on issues of social justice. Unlike some circuit courts which have reputations in the area of social justice built around one or two fields, such as the Fifth Circuit’s pioneering role in civil rights litigation or the Ninth Circuit’s focus on immigration, there is no one area of …

Are Intrusion Detection Studies Evaluated Consistently? A Systematic Literature Review, Nuthan Munaiah, Andrew Meneely, Ryan Wilson, Benjamin Short

Articles

Cyberinfrastructure is increasingly becoming target of a wide spectrum of attacks from Denial of Service to large-scale defacement of the digital presence of an organization. Intrusion Detection System (IDSs) provide administrators a defensive edge over intruders lodging such malicious attacks. However, with the sheer number of different IDSs available, one has to objectively assess the capabilities of different IDSs to select an IDS that meets specific organizational requirements. A prerequisite to enable such an objective assessment is the implicit comparability of IDS literature. In this study, we review IDS literature to understand the implicit comparability of IDS literature from the …

Measurement Of Cortical Thickness Asymmetry In Carotid Occlusive Disease, Iris Asllania, Pamelia Slattery, Alexander Fafard, Marykay Pavol, Ronald M. Lazar, Randolph S. Marshall

Articles

Despite being considered an important anatomical parameter directly related to neuronal density, cortical thickness is not routinely assessed in studies of the human brain in vivo. This paucity has been largely due to the size and convoluted shape of the human cortex, which has made it difficult to develop automated algorithms that can measure cortical thickness efficiently and reliably. Since the development of such an algorithm by Fischl and Dale in 2000, the number of studies investigating the relationship between cortical thickness and other physiological parameters in the brain has been on the rise. There have been no studies however …

Short Term Forecasting Of Nitrogen Dioxide (No2) Levels Using A Hybrid Statistical And Air Mass History Modelling Approach, Aoife Donnelly, Owen Naughton, Brian Broderick, Bruce Misstear

Articles

A novel hybrid model has been developed to support the provision of real-time air quality forecasts. Statistical techniques have been applied in parallel with airmass history modelling to provide an efficient and accurate forecasting system with the ability to identify high NO2 events, which tend to be the episodes ofmost significance in Ireland. Airmass history modelling and k-means clustering are used to identify air mass types that lead to high NO2 levels in Ireland. Trajectory matching techniques allow data associated with these air masses to be partitioned during model development. Non-parametric regression (NPR) has been applied to describe nonlinear variations …

Thoughts On Treasury's White Paper On Eu State Aid, Jeffrey M. Kadet

Articles

The U.S. Department of the Treasury on August 24 issued a White Paper that expresses its concerns about the European Commission’s efforts to apply the European Union’s State aid restrictions to multinational enterprises’ profit-shifting structures. This article comments on two aspects of the white paper that are technically correct, but require a little more explanation for readers to understand their significance. These two aspects are:

First, the article clarifies that the general comments that the White Paper makes about “call[ing] into question the ability of Member States to honor their bilateral tax treaties” might be true, but the specifics of …

The Economic Boom, Bust And Transport Inequity In Suburban Dublin, Ireland, Sarah Rock, Aoife Ahern, Brian Caulfield

Articles

This paper examines the existence and extent of transport inequity and disadvantage in new suburbs in Dublin, built during the Celtic Tiger period and as experienced during the recession. Findings are presented from a household postal survey from three case study areas built between 2001 and 2008. The case study areas are typical 'middle class' suburbs, and were constructed at a time when Ireland was experiencing unprecedented economic growth. The subsequent recession left many of these areas in significant negative equity, and householders with very limited housing mobility. Results from the survey point to considerable problems that are impacting on …

The Contours Of Constitutional Approval, Nicholas Stephanopoulos, Mila Versteeg

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No abstract provided.

Information-Dissemination Law: The Regulation Of How Market-Moving Information Is Revealed, M. Todd Henderson, Kevin S. Haeberle

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No abstract provided.

Lux In Arcana: Decoding The Right To Be Forgotten In Digital Archives, Patricia S. Abril, Eugenio Pizarro Moreno

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On 13 May 2014, the European Court of Justice ruled that search engines such as Google had a duty to respect EU citizens' right to be forgotten. That is, the search engines-deemed "controllers" of information under the Directive-were obligated in some circumstances to remove or de-list links from search results that pertain to information that infringes on an individual's rights under the Directive. In the fall of 2015, the Spanish Supreme Court found itself obligated to determine the application of the digital right to be forgotten in a different context: This time in a digital newspaper archive. However, since …

Advancing Android Activity Recognition Service With Markov Smoother: Practical Solutions, Mingyang Zhong, Jiahui Wen, Peizhao Hu, Jadwiga Indulska

Articles

Common use of smartphones is a compelling reason for performing activity recognition with on-board sensors as it is more practical than other approaches, such as wearable sensors and augmented environments. Many solutions have been proposed by academia, but practical use is limited to experimental settings. Ad hoc solutions exist with different degrees in recognition accuracy and efficiency. To ease the development of activity recognition for the mobile application eco-system, Google released an activity recognition service on their Android platform. In this paper, we present a systematic evaluation of this activity recognition service and share the lesson learnt. Through our experiments, …

From Integrationism To Equal Protection: Tenbroek And The Next 25 Years Of Disability Rights, Samuel R. Bagenstos

Articles

If there is one person who we can say is most responsible for the legal theory of the disability rights movement, that person is Jacobus tenBroek. Professor tenBroek was an influential scholar of disability law, whose writings in the 1960s laid the groundwork for the disability rights laws we have today. He was also an influential disability rights activist. He was one of the founders and the president for more than two decades of the National Federation of the Blind, one of the first-and for many years undisputedly the most effective-of the organizations made up of people with disabilities that …

Faith And Unbelief : Brian Moore's Priestly Depictions, Eamon Maher

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No abstract provided.

Gold Nanostars For Efficient In Vitro And In Vivo Real-Time Sers Detection And Drug Delivery Via Plasmonic-Tunable Raman/Ftir Imaging, Furong Tian, Joao Conde, Chenchen Bao, Yunsheng Chen, James Curtin, Daxiang Cui

Articles

The application of plasmonic-enhanced Raman imaging of cancer cells and drug delivery is gaining momentum. Here, we propose a new theranostic strategy based on an efficient plasmonic-tunable Raman/Fourier transform infrared (FTIR) spectroscopy imaging, to simultaneously evaluate the anticancer drug scattering cellular imaging and the Raman scattering molecular vibration signals in living cells. This technique allows to monitoring the drug release throughout the cell cycle and in vivo biodistribution and biocompatibility with low dose drug therapy (200 µg/mL) and low toxicity effect. This system can directly track in real-time the delivery and release of an anticancer drug (mitoxantrone, MTX) from gold …

Jurisdiction And Resentencing: How Prosecutorial Waiver Can Offer Remedies Congress Has Denied, Leah Litman, Luke C. Beasley

Articles

This Essay is about what prosecutors can do to ensure that prisoners with meritorious legal claims have a remedy. The Antiterrorism and Effective Death Penalty Act (AEDPA) imposes draconian conditions on when prisoners may file successive petitions for post-conviction review (that is, more than one petition for post-conviction review). AEDPA’s restrictions on post-conviction review are so severe that they routinely prevent prisoners with meritorious claims from vindicating those claims.

Profit-Shifting Structures: Making Ethical Judgments Objectively, Part 2, Jeffrey M. Kadet, David Koontz

Articles

MNCs and their advisors have seemingly taken ethics out of the mix when considering the profit-shifting tax structures they have so prolifically and enthusiastically implemented over the past several decades. There may be a variety of reasons for this. First, U.S. tax law is a self-assessment system, meaning that in most cases taxpayers compute and pay tax without advance approval of their tax positions from the IRS. No third party technical test or propriety standard has to be passed on the front end for any tax strategy or structure. Second, direct personal benefits accrue to management and advisors from implementing …

Struggles With The Fairer Sex : George Moore's Fr. Oliver Gogarty In 'The Lake', Eamon Maher

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No abstract provided.

Personalizing Negligence Law, Omri Ben-Shahar, Ariel Porat

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No abstract provided.

The Positive Psychology Of Maritime Health, Joanne Mcveigh, Malcolm Mclachlan, Bill Kavanagh

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The remote, isolated, confined, and safety-critical environment of seafaring exposes seafarers to a very specific assortment of stressors. Research suggests that seafarers as a professional group are amongst those at high risk for stress and associated mental health conditions. This article explores positive psychology as an approach to supporting wellbeing at sea. Positive psychology may support health, positive attitudes and productive work behaviour; however it cannot and should not be employed as a means of inoculating seafarers against the negative consequences of fundamentally unreasonable work practices. Rather, positive psychology can help seafarers thrive in an overall context that recognises and …

Balance-Of-Powers Arguments, The Structural Constitution, And The Problem Of Executive "Underenforcement", Eric A. Posner

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No abstract provided.

Rational Basis Review And Fda Regulation: Why The Two Do Not Mix, Richard A. Epstein

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No abstract provided.

How To Study Constitution-Making: Hirschl, Elster, And The Seventh Inning Problem, Tom Ginsburg

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No abstract provided.

The Role Of Guidances In Modern Administrative Procedure: The Case For De Novo Review, Richard A. Epstein

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No abstract provided.

3 E’S Enterprise Architecture Framework (That Encompasses Business Process, Information Systems, And Information Technology), Nicholas C. Bucciarelli Mr.

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No abstract provided.

Profit-Shifting Structures: Making Ethical Judgments Objectively, Part 1, Jeffrey M. Kadet, David Koontz

Articles

MNCs and their advisors have seemingly taken ethics out of the mix when considering the profit-shifting tax structures they have so prolifically and enthusiastically implemented over the past several decades. There may be a variety of reasons for this. First, U.S. tax law is a self-assessment system, meaning that in most cases taxpayers compute and pay tax without advance approval of their tax positions from the IRS. No third party technical test or propriety standard has to be passed on the front end for any tax strategy or structure. Second, direct personal benefits accrue to management and advisors from implementing …

A Complainant-Oriented Approach To Unconscionability And Contract Law, Nicholas Cornell

Articles

This Article draws attention to a conceptual point that has been overlooked in recent discussions about the theoretical foundations of contract law. I argue that, rather than enforcing the obligations of promises, contract law concerns complaints against promissory wrongs. This conceptual distinction is easy to miss. If one assumes that complaints arise whenever an obligation has been violated, then the distinction does not seem meaningful. I show, however, that an obligation can be breached without giving rise to a valid complaint. This Article illustrates the importance of this conceptual distinction by focusing first on the doctrine of substantive unconscionability. I …

Linguistic Relativism And The Decline Of The Rule Of Law, Richard A. Epstein

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No abstract provided.