Digital Commons Network^™

Low-Dose (0.01%) Atropine Eye Drops To Reduce Progression Of Myopia In Children: A Multi-Centre Placebo- Controlled Randomised Trial In The United Kingdom (Champ- Uk) – Study Protocol., Augusto Azuara-Blanco, Nicola Logan, Niall Strang, Peter Allen, Ruth Hogg, Ruth Weir, Paul Doherty, Catherine Adams, Margaret Mcfarland, Evie Gardner, Rejina Verghis, Jennifer Preston, James Loughman, Daniel I. Flintcroft, David Mackey, Samantha Lee, Christopher Hammond, Nathan Congdon, Mike Clarke

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Background/aims To report the protocol of a trial designed to evaluate the efficacy, safety and mechanism of action of low-dose atropine (0.01%) eye-drops for reducing progression of myopia in UK children. Methods Multicentre, double-masked, superiority, placebo-controlled, randomised trial. We will enrol children aged 6–12 years with myopia of −0.50 dioptres or worse in both eyes. We will recruit 289 participants with an allocation ratio of 2:1 (193 atropine; 96 placebo) from five centres. Participants will instil one drop in each eye every day for 2 years and attend a research centre every 6 months. The vehicle and preservative will be …

Data Mining Raman Microspectroscopic Responses Of Cells To Drugs In Vitro Using Multivariate Curve Resolution-Alternating Least Squares, David Perez-Guaita, Guillermo Quintas, Zeineb Farhane, Roma Tauler, Hugh Byrne

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Raman microspectroscopy is gaining popularity for the analysis of time-dependent biological processes such as drug uptake and cellular response. It is a label-free technique which acquires signals from a large variety of components, including cell biomolecules and exogenous compounds such as drugs and nanoparticles, and is commonly employed for in vitro analysis of cells and cell populations with no labelling or staining required. By monitoring the changes to the Raman spectra of the cell as a result of a perturbing agent (e.g. inoculation of a drug or toxic agent), one can study the associated changes in cell biochemistry involved in …

Mere Conduit, David G. Carlson

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"Mere conduit" is a legal fiction in fraudulent transfer and other avoidance cases. This article argues that the legal fiction is misleading, unnecessary and rendered obsolete by the Supreme Court's recent opinion in Merit Management Group v. FTI Consulting, Inc. (2018). The article further contends that a huge majority of leading cases confound fraudulent transfer law with the law of corporate theft. This error leads to depriving financial intermediaries of their opportunity to avoid liability on the ground of being bona fide transferees for value. Finally, courts often mistake banks as initial transferees of fraudulent transfers (absolutely liable in spite …

Response To: How Should We Respond To Pregnancy And Substance Use?, Frank E. E. Vandervort, Vincent J. Palusci

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We begin our reply by asking the reader to consider this typical case taken from Professor Vandervort’s current practice. It is one of several similar cases currently being handled by the clinic he works in and similar to many dozens—perhaps hundreds—of cases handled over the past 30 years.

Seaweeds As Nutraceuticals For Health And Nutrition, Emer Shannon, Nissreen Abu-Ghannam

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Throughout human history, seaweeds have been used as food, folk remedies, dyes, and as mineral-rich fertilisers. Seaweeds as nutraceuticals or functional foods with dietary benefits beyond their fundamental macronutrient content are now a major research and industrial development concept. The occurrence of dietary and lifestyle related diseases, notably type 2 diabetes, obesity, cancer, and metabolic syndrome has become a health epidemic in developed countries. Global epidemiological studies have shown that countries where seaweed is consumed on a regular basis have significantly fewer instances of obesity and dietary-related disease. This review outlines recent developments in seaweed applications for human health from …

Ireland In The European Eye: At Home In The Heart Of Europe : Book Review: An Excellent Analysis Of Ireland’S Interactions With Its European Allies, Eamon Maher

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This essay collection provides an excellent analysis of Ireland’s various interactions with its European allies, from the early medieval period up to the present moment. The essays cover things as diverse as history, religion, literature, tourism, politics, trade, journalism, architecture, music and film in 22 chapters by experts from various disciplines, who serve up an informative and welcome survey that emphasises the historical ties that bind the Emerald Isle to its largest neighbour and the Continent.

Association Of Total Zinc Intake With Myopia In U.S. Children And Adolescents, Niamh Burke, John Butler, Daniel Ian Flitcroft, Daniel Mccartney, James Loughman

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Significance: This present study advances our knowledge on the role of lifestyle factors in myopia (short-sightedness), specifically dietary factors. It has been suggested in previous studies that lower zinc status is associated with myopia; however, this article shows no relationship between dietary zinc intake and myopia in U.S. adolescents. Purpose: It has been suggested that low zinc levels may contribute to the development of myopia. The aim of the present study is to examine, for the first time in a Western population, the association of total dietary and supplement zinc intake with myopia. Methods: A total of 1095 children/adolescents aged …

Medical Ai And Contextual Bias, W. Nicholson Price Ii

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Artificial intelligence will transform medicine. One particularly attractive possibility is the democratization of medical expertise. If black-box medical algorithms can be trained to match the performance of high-level human experts — to identify malignancies as well as trained radiologists, to diagnose diabetic retinopathy as well as board-certified ophthalmologists, or to recommend tumor-specific courses of treatment as well as top-ranked oncologists — then those algorithms could be deployed in medical settings where human experts are not available, and patients could benefit. But there is a problem with this vision. Privacy law, malpractice, insurance reimbursement, and FDA approval standards all encourage developers …

E-Notice And Comment On Due Process, Sergio J. Campos

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No abstract provided.

What Is The Source Of Bilingual Cross-Language Activation In Deaf Bilinguals?, Jill P. Morford, Corrine Occhino, Megan Zirnstein, Judith F. Kroll, Erin Wilkinson, Pilar Piñar

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When deaf bilinguals are asked to make semantic similarity judgments of two written words, their responses are influenced by the sublexical relationship of the signed language translations of the target words. This study investigated whether the observed effects of ASL activation on English print depend on (a) an overlap in syllabic structure of the signed translations or (b) on initialization, an effect of contact between ASL and English that has resulted in a direct representation of English orthographic features in ASL sublexical form. Results demonstrate that neither of these conditions is required or enhances effects of cross-language activation. The experimental …

Corresponding Ideas In Corresponding Forms, Patrick Barry

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Don’t make the mistake of thinking that content always comes before structure. You don’t need to figure out all your ideas before you decide how to organize them. Much value can come from going in the opposite direction: first figure out how you are going to organize your ideas—their appropriate structure—and then determine the appropriate content. I often offer law students the following suggestion: “Once you find the right structure, perhaps it will be easier to find the right content.”

Incentivizing Therapies For Rare Diseases, Laura Karas

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No abstract provided.

A Density-Based Approach For Leaf Area Index Assessment In A Complex Forest Environment Using A Terrestrial Laser Scanner, Ali Rouzbeh Kargar, Richard Mackenzie, Gregory P. Asner, Jan Van Aardt

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Forests are an important part natural ecosystems, by for example providing food, fiber, habitat, and biodiversity, all of which contribute to stable natural systems. Assessing and modeling the structure and characteristics of forests, e.g., Leaf Area Index (LAI), volume, biomass, etc., can lead to a better understanding and management of these resources. In recent years, Terrestrial Laser Scanning (TLS) has been recognized as a tool that addresses many of the limitations of manual and traditional forest data collection methods. In this study, we propose a density-based approach for estimating the LAI in a structurally-complex forest environment, which contains variable and …

A Functional Approach To Judicial Review Of Ptab Rulings On Mixed Questions Of Law And Fact, Rebecca S. Eisenberg

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The Court of Appeals for the Federal Circuit (“Federal Circuit”) has long relied on active appellate review to bring uniformity and clarity to patent law. It initially treated the PTO the same as the federal district courts, reviewing its factual findings for clear error and its legal conclusions de novo. Following reversal by the Supreme Court in Dickinson v. Zurko, the Federal Circuit began giving greater deference to PTO factual findings. But it continued to review the PTO’s legal conclusions de novo, while coding an expansive list of disputed issues in patent cases as legal conclusions, even when they …

On A Diagonal Conjecturefor Classical Ramsey Numbers, Meilian Liang, Stanislaw Radziszowski, Xiaodong Xu

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Let R(k1, · · · , kr) denote the classical r-color Ramsey number for integers ki ≥ 2. The Diagonal Conjecture (DC) for classical Ramsey numbers poses that if k1, · · · , kr are integers no smaller than 3 and kr−1 ≤ kr, then R(k1, · · · , kr−2, kr−1 − 1, kr + 1) ≤ R(k1, · · · , kr). We obtain some implications of this conjecture, present evidence for its validity, and discuss related problems. Let Rr(k) stand for the r-color Ramsey number R(k, · · · , k). It is known that limr→∞ …

Runge–Kutta–Gegenbauer Explicit Methods For Advection-Diffusion Problems, Stephen O'Sullivan

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In this paper, Runge-Kutta-Gegenbauer (RKG) stability polynomials of arbitrarily high order of accuracy are introduced in closed form. The stability domain of RKG polynomials extends in the the real direction with the square of polynomial degree, and in the imaginary direction as an increasing function of Gegenbauer parameter. Consequently, the polynomials are naturally suited to the construction of high order stabilized Runge-Kutta (SRK) explicit methods for systems of PDEs of mixed hyperbolic-parabolic type.

We present SRK methods composed of L ordered forward Euler stages, with complex-valued stepsizes derived from the roots of RKG stability polynomials of degree $L$. Internal stability …

A Cure Worse Than The Disease? The Impact Of Removal On Children And Their Families, Vivek Sankaran, Christopher Church, Monique Mitchell

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Removing children from their parents is child welfare's most drastic intervention. Research clearly establishes the profound and irreparable damage family separation can inflict on children and their parents. To ensure that this intervention is only used when necessary, a complex web of state and federal constitutional principles, statutes, administrative regulations, judicial decisions, and agency policies govern the removal decision. Central to these authorities is the presumption that a healthy and robust child welfare system keeps families together, protects children from harm, and centers on the needs of children and their parents. Yet, research and practice-supported by administrative data-paint a different …

Pharmaceutical Industry Funding To Patient-Advocacy Organization: A Cross-National Comparison Of Disclosure Codes And Regulation, Laura Karas, Robin Feldman, Bai Ge, So Yeon Kang, Gerard F. Anderson

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Transparency has become one of the primary themes in health care reform efforts in the United States and across the world. In the face of exorbitant drug prices, high levels of patient cost-sharing, and pharmaceutical expenditures that consume a growing proportion of public sector budgets, much attention has been drawn to the pharmaceutical industry. Congressional investigations, academic publications, and news articles have endeavored to reveal the extent of drug and device industry influence on health care actors. In response, several nations, including the United States, have passed legislation mandating disclosure of drug company payments to physicians. In the United States, …

What American Legal Education Can Learn From The 'Harry Potter' Series, Sarah Gerwig-Moore

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Both legal education and a Hogwarts magical education involve a new way of seeing the world—an immersive and intense process requiring, in many ways, a transformation. Students need a new wardrobe for both law school and wizarding school—and an awful lot of puzzling and expensive textbooks. Both Hogwarts and law school have been accused of operating entirely apart from reality. One of these criticisms may be valid. ...

This lighthearted comparison to the Harry Potter stories can perhaps join other voices to help make a serious and important case for practical legal education. There are few principled reasons for not …

Quantifying Entanglement In A 68-Billion Dimensional Quantum State Space, James Schneeloch, Christopher C. Tison, Michael L. Fanto, Paul M. Alsing, Gregory A. Howland

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Entanglement is the powerful and enigmatic resource central to quantum information processing, which promises capabilities in computing, simulation, secure communication, and metrology beyond what is possible for classical devices. Exactly quantifying the entanglement of an unknown system requires completely determining its quantum state, a task which demands an intractable number of measurements even for modestly-sized systems. Here we demonstrate a method for rigorously quantifying high-dimensional entanglement from extremely limited data. We improve an entropic, quantitative entanglement witness to operate directly on compressed experimental data acquired via an adaptive, multilevel sampling procedure. Only 6,456 measurements are needed to certify an entanglement-of-formation …

Bernard Maclaverty: A Novelist With A Catholic Sensibiliy., Eamon Maher

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Like many others I would imagine, my first introduction to the work of the Belfast writer Bernard MacLaverty (born in 1942) was through the successful film adaptations of his first novel, Lamb, with Liam Neeson in the main role, and the highly successful ‘Troubles’ film, Cal, based on the novel of the same name. Nominated for several prestigious literary awards, a member of Aosdána, author of numerous well-regarded novels and short story collections, MacLaverty is nevertheless largely neglected in terms of the critical attention he has attracted. The shining exceptions are the essay collection, About Bernard MacLaverty: New …

The Elusive Object Of Punishment, Gabriel S. Mendlow

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All observers of our legal system recognize that criminal statutes can be complex and obscure. But statutory obscurity often takes a particular form that most observers have overlooked: uncertainty about the identity of the wrong a statute aims to punish. It is not uncommon for parties to disagree about the identity of the underlying wrong even as they agree on the statute’s elements. Hidden in plain sight, these unexamined disagreements underlie or exacerbate an assortment of familiar disputes—about venue, vagueness, and mens rea; about DUI and statutory rape; about hate crimes, child pornography, and counterterrorism laws; about proportionality in punishment; …

Social Clustering In Epidemic Spread On Coevolving Networks, Hsuan-Wei Lee, Nishant Malik, Feng Shi, Peter J. Mucha

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Even though transitivity is a central structural feature of social networks, its influence on epidemic spread on coevolving networks has remained relatively unexplored. Here we introduce and study an adaptive susceptible- infected-susceptible (SIS) epidemic model wherein the infection and network coevolve with nontrivial proba- bility to close triangles during edge rewiring, leading to substantial reinforcement of network transitivity. This model provides an opportunity to study the role of transitivity in altering the SIS dynamics on a coevolving network. Using numerical simulations and approximate master equations (AMEs), we identify and examine a rich set of dynamical features in the model. In …

Location Tracking And Digital Data: Can Carpenter Build A Stable Privacy Doctrine?, Evan H. Caminker

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In Carpenter v United States, the Supreme Court struggled to modernize twentieth-century search and seizure precedents for the “Cyber Age.” Twice previously this decade the Court had tweaked Fourth Amendment doctrine to keep pace with advancing technology, requiring a search warrant before the government can either peruse the contents of a cell phone seized incident to arrest or use a GPS tracker to follow a car’s long-term movements.

Article Ii Vests Executive Power, Not The Royal Prerogative, Julian Davis Mortenson

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Article II of the United States Constitution vests “the executive power” in the President. For more than two hundred years, advocates of presidential power have claimed that this phrase was originally understood to include a bundle of national security and foreign affairs authorities. Their efforts have been highly successful. Among constitutional originalists, this so-called “Vesting Clause Thesis” is now conventional wisdom. But it is also demonstrably wrong. Based on an exhaustive review of the eighteenth-century bookshelf, this Article shows that the ordinary meaning of “executive power” referred unambiguously to a single, discrete, and potent authority: the power to execute law. …

Strengthening The Passivity Default, Ian Ayres, Edward Fox

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In The Prudence of Passivity, Bryon Harmon and Laura Fisher (hereafter HF) argue that "passive management become the default approach for the investment of trust funds, to be abandoned only when circumstances specifically dictate the use of active management."' In this comment we argue that their thesis could be strengthened (i) by more clearly distinguishing between default law and default investment practices, (ii) by more clearly articulating their favored altering rules.

Janus's Two Faces, Kate Andrias

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In ancient Roman religion and myth, Janus is the god of beginnings, transitions, and endings. He is often depicted as having two faces, one looking to the future and one to the past. The Supreme Court’s Janus v AFSCME case of last Term is fittingly named.1 Stunning in its disregard of principles of stare decisis, Janus overruled the forty-yearold precedent Abood v Detroit Board of Education. 2 The Janus decision marks the end of the post–New Deal compromise with respect to public sector unions and the FirstAmendment.Looking to the future, Janus lays the groundwork for further attack on labor rights—as …

Misunderstanding Judy Norman: Theory As Cause And Consequence, Martha R. Mahoney

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Judy Norman shot her abusive husband during a late afternoon nap while he rested before violently trafficking her that night. The sharp contrast between the extreme violence and danger Judy faced and the denial of a self-defense instruction triggered extensive academic debates about justification and the use of deadly force. Norman became one of the most famous cases involving battered women, appearing in many casebooks and hundreds of law review articles. Despite all this work, the facts of the case contradict much of what scholars have said about Norman. Misconceptions about expert evidence, "Battered Woman Syndrome, "and battered women drive …

Influence Of Drone Altitude, Image Overlap, And Optical Sensor Resolution On Multi-View Reconstruction Of Forest Images, Erich Seifert, Stefan Seifert, Holger Vogt, David Drew, Jan Van Aardt, Thomas Seifert

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No abstract provided.

Dignity And Civility, Reconsidered, Leah Litman

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People often talk about the Chief Justice, Justice Kagan, and Justice Breyer as the institutionalists on the modern Supreme Court. And that’s true, they are. Those Justices care about the Court as an institution and the Court’s reputation. They do not want people to look at the Court as a set of politicians in robes; and they do not want people to see judges as having ideological or partisan agendas. That is how they think of themselves, and they are willing to make compromises to maintain that image of the Court, and to set aside their personal beliefs in order …