Digital Commons Network^™

Seaweeds As Nutraceuticals For Health And Nutrition, Emer Shannon, Nissreen Abu-Ghannam

Articles

Throughout human history, seaweeds have been used as food, folk remedies, dyes, and as mineral-rich fertilisers. Seaweeds as nutraceuticals or functional foods with dietary benefits beyond their fundamental macronutrient content are now a major research and industrial development concept. The occurrence of dietary and lifestyle related diseases, notably type 2 diabetes, obesity, cancer, and metabolic syndrome has become a health epidemic in developed countries. Global epidemiological studies have shown that countries where seaweed is consumed on a regular basis have significantly fewer instances of obesity and dietary-related disease. This review outlines recent developments in seaweed applications for human health from …

Ireland In The European Eye: At Home In The Heart Of Europe : Book Review: An Excellent Analysis Of Ireland’S Interactions With Its European Allies, Eamon Maher

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This essay collection provides an excellent analysis of Ireland’s various interactions with its European allies, from the early medieval period up to the present moment. The essays cover things as diverse as history, religion, literature, tourism, politics, trade, journalism, architecture, music and film in 22 chapters by experts from various disciplines, who serve up an informative and welcome survey that emphasises the historical ties that bind the Emerald Isle to its largest neighbour and the Continent.

Operationalizing Learning From Rare Events: Framework For Middle Humanitarian Operations Managers, Amr Mahfouz, Ashraf Labib, Sara Hadleigh-Dunn, Marco Gentile

Articles

The purpose of this paper is to investigate the learning from rare events and the knowledge management processinvolved, which presents a significant challenge to many organizations. This is primarily attributed to the inability tointerpret these events in a systematic and “rich” manner, which this paper seeks to address. We start by summarizing therelevant literature on humanitarian operations management (HOM), outlining the evolution of the socio-technical disasterlifecycle and its relationship with humanitarian operations, using a supply chain resilience theoretical lens. We then out-line theories of organizational learning (and unlearning) from disasters and the impact on humanitarian operations. Subse-quently, we theorize the …

Association Of Total Zinc Intake With Myopia In U.S. Children And Adolescents, Niamh Burke, John Butler, Daniel Ian Flitcroft, Daniel Mccartney, James Loughman

Articles

Significance: This present study advances our knowledge on the role of lifestyle factors in myopia (short-sightedness), specifically dietary factors. It has been suggested in previous studies that lower zinc status is associated with myopia; however, this article shows no relationship between dietary zinc intake and myopia in U.S. adolescents. Purpose: It has been suggested that low zinc levels may contribute to the development of myopia. The aim of the present study is to examine, for the first time in a Western population, the association of total dietary and supplement zinc intake with myopia. Methods: A total of 1095 children/adolescents aged …

Corresponding Ideas In Corresponding Forms, Patrick Barry

Articles

Don’t make the mistake of thinking that content always comes before structure. You don’t need to figure out all your ideas before you decide how to organize them. Much value can come from going in the opposite direction: first figure out how you are going to organize your ideas—their appropriate structure—and then determine the appropriate content. I often offer law students the following suggestion: “Once you find the right structure, perhaps it will be easier to find the right content.”

An“Astonishingly Excellent” Solution To Super-Fake Narratives, Cathren Page

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Persuasion studies indicate that facts and logic have likely never persuaded people. Rather, people typically hold “deep frame” beliefs, and story persuades them. People then use facts and logic to justify their beliefs.

While this potentially persuasive “fake news” itself is old, the widespread dissemination of fake news via bots is new. Donald Trump’s campaign benefitted from these bots and from an electoral college map more favorable to Republicans. But these super-powers were not his only strengths, the Trump campaign wielded the power of superhero storytelling techniques.

So, faced with an army of bots, a superhero story, and an unfavorably …

How The Boogeyman Saved Brett Kavanaugh, Cathren Page

Articles

We love to hate these boogeymen. When the societal narrative creates these invisible boogeymen, people can pour their rage against sexual abuse into these faceless antagonists. At the same time, the enraged survivors and protectors avoid conflicts with family, neighbors, colleagues, and social acquaintances who might actually commit or enable sexual abuse. We can dodge sticky questions regarding how a churchgoer, a judge, or an Ivy Leaguer could have committed a heinous act. The survivors can avoid all the victim-blaming backlash, threats of violence, and invalidation that accompanies reporting a sexual offense. Moreover, having less power on their own, survivors …

Rediscovering The Issue Class In Mass Tort Mdls, Myriam E. Gilles, Gary Friedman

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For the past twenty-plus years, MDL transferee judges have essentially regarded the class device as unavailable as they struggle to organize masses of tort actions sent their way by the JPML. Even the badges and incidents of class practice, in the form of common-fund-based approaches to attorney compensation and lead-counsel structures for case organization, have come under attack from commentators who insist that mass-tort MDLs should not be treated as “quasi-class actions,” and that Rule 23 does not present a “grab bag” from which MDL judges may pick and choose the most convenient implements. Leading lights of the complex litigation …

Social Clustering In Epidemic Spread On Coevolving Networks, Hsuan-Wei Lee, Nishant Malik, Feng Shi, Peter J. Mucha

Articles

Even though transitivity is a central structural feature of social networks, its influence on epidemic spread on coevolving networks has remained relatively unexplored. Here we introduce and study an adaptive susceptible- infected-susceptible (SIS) epidemic model wherein the infection and network coevolve with nontrivial proba- bility to close triangles during edge rewiring, leading to substantial reinforcement of network transitivity. This model provides an opportunity to study the role of transitivity in altering the SIS dynamics on a coevolving network. Using numerical simulations and approximate master equations (AMEs), we identify and examine a rich set of dynamical features in the model. In …

The Statistical Optimisation Of Recombinant Β-Glucosidase Production Through A Two-Stage, Multi-Model, Design Of Experiments Approach, Albert Uhoraningoga, Gemma K. Kinsella, Jesus Maria Frias, Gary T. Henehan, Barry J. Ryan

Articles

β-glucosidases are a class of enzyme that are widely distributed in the living world, with examples noted in plants, fungi, animals and bacteria. They offer both hydrolysis and synthesis capacity for a wide range of biotechnological processes. However, the availability of native, or the production of recombinant β-glucosidases, is currently a bottleneck in the widespread industrial application of this enzyme. In this present work, the production of recombinant β-glucosidase from Streptomyces griseus was optimised using a Design of Experiments strategy, comprising a two-stage, multi-model design. Three screening models were comparatively employed: Fractional Factorial, Plackett-Burman and Definitive Screening Design. Four variables …

Dignity And Civility, Reconsidered, Leah Litman

Articles

People often talk about the Chief Justice, Justice Kagan, and Justice Breyer as the institutionalists on the modern Supreme Court. And that’s true, they are. Those Justices care about the Court as an institution and the Court’s reputation. They do not want people to look at the Court as a set of politicians in robes; and they do not want people to see judges as having ideological or partisan agendas. That is how they think of themselves, and they are willing to make compromises to maintain that image of the Court, and to set aside their personal beliefs in order …

Representation Of Caṇḍālas In The Jātakas, Chandrabhan P. Yadav

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Excerpt:

"Out of 547 Jātaka stories, eight describe the caṇḍālas.1 Out of these eight stories, half contain passing references about this social class, but at least four are stories where the protagonists themselves are caṇḍālas. In those four stories which are centred around this class, three are comparatively longer stories, including the famous Mātaṅga-Jātaka (No. 497). These are probably the most elaborate descriptions of this social group from the early historic period. Since the Mātaṅga-Jātaka is more elaborate and complex than the other stories and needs to be discussed separately, I will only discuss the rest of the seven stories …

Neglecting Nationalism, Gil Seinfeld

Articles

Federalism is a system of government that calls for the division of power between a central authority and member states. It is designed to secure benefits that flow from centralization and from devolution, as well as benefits that accrue from a simultaneous commitment to both. A student of modern American federalism, however, might have a very different impression, for significant swaths of the case law and scholarly commentary on the subject neglect the centralizing, nationalist side of the federal balance. This claim may come as a surprise, since it is obviously the case that our national government has become immensely …

Pka, Caspase 1 And Hsp40 Induced Apoptosis Under Fungi Starvation, Tobiloba Sojinrin, Kangze Liu, Daxiang Cui, James Curtin, Furong Tian

Articles

To investigate the influence of starvation on the biochemical response of Aspergillus niger. The biochemical impact of starvation was determined by morphological observation, immunofluorescent analysis, High-performance liquid chromatography (HPLC) and western blot over 8 days. Results showed that starvation can inhibit fungi survival rate in a time-dependent manner. A. niger exhibited active responses to starvation such as secretion of some 40 kDa proteins to manage changes in water balance. Conidiophores disintegrated from lack of nutrient. The immunofluorescent analysis demonstrated elevated ROS accumulation in starved cells (PA. niger growth by inducing cell apoptosis.

Equitable Gateways: Toward Expanded Federal Habeas Corpus Review Of State Court Criminal Convictions, Eve Brensike Primus

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State prisoners who file federal habeas corpus petitions face a maze of procedural and substantive restrictions that effectively prevent almost all prisoners from obtaining meaningful review of their convictions. But it is a mistake to think that habeas litigation is just a Kafkaesque nightmare with no constructive potential. Federal courts do sometimes cut through the doctrinal morass to consider state prisoners’ claims, relying on what this Articleterms "equitable gateways" to federal habeas relief. Litigants and courts generally underestimate the potential these gateways offer, with the result that habeas litigation does not focus on them as often as it should. Here …

Analysis Of Human Mitochondrial Dna Content By Southern Blotting And Nonradioactive Probe Hybridization., Joel H Wheeler, Carolyn K J Young, Matthew J Young

Articles

A single cell can contain several thousand copies of the mitochondrial DNA genome or mtDNA. Tools for assessing mtDNA content are necessary for clinical and toxicological research, as mtDNA depletion is linked to genetic disease and drug toxicity. For instance, mtDNA depletion syndromes are typically fatal childhood disorders that are characterized by severe declines in mtDNA content in affected tissues. Mitochondrial toxicity and mtDNA depletion have also been reported in human immunodeficiency virus-infected patients treated with certain nucleoside reverse transcriptase inhibitors. Further, cell culture studies have demonstrated that exposure to oxidative stress stimulates mtDNA degradation. Here we outline a Southern …

Securities Disclosure As Soundbite: The Case Of Ceo Pay Ratios, Steven A. Bank, George S. Georgiev

Articles

This Article analyzes the history, design, and effectiveness of the highly controversial CEO pay ratio disclosure rule, which went into effect in 2018. Based on a regulatory mandate contained in the Dodd-Frank Act of 2010, the rule requires public companies to disclose the ratio between CEO pay and median worker pay as part of their annual filings with the Securities and Exchange Commission (SEC). The seven-year rulemaking process was politically contentious and generated a level of public engagement that was virtually unprecedented in the long history of the SEC disclosure regime. The SEC sought to minimize compliance costs by providing …

Tribes, Cities, And Children: Emerging Voices In Environmental Litigation, Nina A. Mendelson

Articles

an environmental nongovernmental organization ("NGO") on behalf of a neighbor or hiker.1 The NGO would allege that the individual faced health risks, that her property was contaminated, or that she could no longer hike, fish, swim, or view wildlife such as the endangered Nile crocodile, as in the well-known case of Lujan v. Defenders of Wildlife.

Ly379268 Does Not Have Long-Term Procognitive Effects Nor Attenuate Glutamatergic Signaling In Aβpp/Ps1 Mice., Kevin N Hascup, Jesse Britz, Caleigh Findley, Shelley Tischkau, Erin R. Hascup

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No abstract provided.

Effect Of Fermentation On Enhancing The Nutraceutical Properties Of Arthrospira Platensis (Spirulina), Elena Demarcocastro, Emer Shannon, Nissreen Abu-Ghannam

Articles

Abstract:Arthrospira platensis(spirulina), a filamentous fresh-water planktonic cyanobacterium,possesses diverse biological activities and a unique nutritional profile, due to its high contentof valuable nutrients. This study aimed to further improve the bioactive profile of spirulina, byfermenting it with the lactic acid bacteriumLactobacillus plantarum.In vitrocomparison of thetotal phenolic content (TPC), C-phycocyanin, free methionine, DPPH radical scavenging capacity,ferric reducing antioxidant power (FRAP), oxygen radical absorbance capacity (ORAC) and proteinfragmentation via SDS-PAGE in untreated versus 12 to 72 h fermented spirulina is reported here.After 36 h fermentation, TPC was enhanced by 112%, FRAP by 85% and ORAC by 36%. After 24 h,the DPPH radical scavenging …

The Impact Of Spatial Occlusion Goggles On The Basketball Crossover Dribble, Alan Dunton, Cian O' Neill Phd, Edward K. Coughlan Phd

Articles

Spatial occlusion involves removing specific sources of visual information such as an object, limb or other information from the visuomotor workspace. In the sports context, limiting an athlete’s visual system to sub-optimal conditions during complex motor skills such as the basketball dribble may be detrimental to performance. However, when normal visual conditions are returned performance may rise above its previous threshold, as athletes then rely less on visual information. In this study, we randomly assigned skilled basketball players into three groups; spatial occlusion (SPO), practice (PRA) and control (CON) and asked participants to execute a basketball crossover dribble task in …

The Human Ortholog Of Archaeal Pus10 Produces Pseudouridine 54 In Select Trnas Where Its Recognition Sequence Contains A Modified Residue., Manisha Deogharia, Shaoni Mukhopadhyay, Archi Joardar, Ramesh Gupta

Articles

The nearly conserved U54 of tRNA is mostly converted to a version of ribothymidine (T) in Bacteria and eukaryotes and to a version of pseudouridine (Ψ) in Archaea. Conserved U55 is nearly always modified to Ψ55 in all organisms. Orthologs of TrmA and TruB that produce T54 and Ψ55, respectively, in Bacteria and eukaryotes are absent in Archaea. Pus10 produces both Ψ54 and Ψ55 in Archaea. Pus10 orthologs are found in nearly all sequenced archaeal and most eukaryal genomes, but not in yeast and bacteria. This coincides with the presence of Ψ54 in most archaeal tRNAs and some animal tRNAs, …

Cannabis For Medical Use: Fda And Dea Regulation In The Hall Of Mirrors, Rebecca S. Eisenberg, Deborah B. Leiderman

Articles

A majority of Americans now live in states that purport to authorize medical use of cannabis, although federal law continues to prohibit both recreational and medical use. The current legal regime for cannabis is unstable and may be more effective at deterring research than it is at deterring medical use. Lack of data on medical cannabis products poses public health risks as well as policy and legal challenges. Modified regulatory approaches for other kinds of products provide alternative models for encouraging safety and effectiveness research and providing better information about cannabis products already in clinical use.

Moving Towards The Second Generation Of Lignocellulosic Biorefineries In The Eu: Drivers, Challenges, And Opportunities, Shady S. Hassan, Gwilym A. Williams, Amit K. Jaiswal

Articles

The EU aims to achieve a variety of ambitious climate change mitigation and sustainable development goals by 2030. To deliver on this aim, the European Commission (EC) launched the bioeconomy strategy in 2012. At the heart of this policy is the concept of the sustainable Biorefinery, which is based centrally on a cost-effective conversion of lignocellulosic biomass into bioenergy and bioproducts. The first generation of biorefineries was based on utilization of edible food crops, which raised a “food vs. fuel” debate and questionable sustainability issues. To overcome this, lignocellulosic feedstock options currently being pursued range from non-food crops to agroforestry …

Long-Term Evidence For Fire As An Ecohydrologic Threshold-Reversal Mechanism On Woodland-Encroached Sagebrush Shrublands, Christopher Jason Williams, Frederick B. Pierson, Sayjro K. Nouwakpo, Patrick R. Kormos, Osama Z. Al-Hamdan, Mark A. Weltz

Articles

Encroachment of sagebrush (Artemisia spp.) shrublands by pinyon (Pinus spp.) and juniper (Juniperus spp.) conifers (woodland encroachment) induces a shift from biotic‐controlled resource retention to abiotic‐driven loss of soil resources. This shift is driven by a coarsening of the vegetation structure with increasing dominance of site resources by trees. Competition between the encroaching trees and understory vegetation for limited soil and water resources facilitates extensive bare intercanopy area between trees and concomitant increases in run‐off and erosion that, over time, propagate persistence of the shrubland‐to‐woodland conversion. We evaluated whether tree removal by burning can decrease late‐succession woodland …

Biovr: A Platform For Virtual Reality Assisted Biological Data Integration And Visualization, Jimmy F. Zhang, Alex R. Paciorkowski, Paul A. Craig, Feng Cui

Articles

Background: Functional characterization of single nucleotide variants (SNVs) involves two steps, the first step is to convert DNA to protein and the second step is to visualize protein sequences with their structures. As massively parallel sequencing has emerged as a leading technology in genomics, resulting in a significant increase in data volume, direct visualization of SNVs together with associated protein sequences/structures in a new user interface (UI) would be a more effective way to assess their potential effects on protein function. Results: We have developed BioVR, an easy-to-use interactive, virtual reality (VR)-assisted platform for integrated visual analysis of DNA/RNA/protein sequences …

Comparison Of Heparg Cells Following Growth In Proliferative And Differentiated Culture Conditions Reveals Distinct Bioenergetic Profiles., Carolyn K J Young, Matthew J Young

Articles

HepaRG is a proliferative human hepatoma-derived cell line that can be differentiated into hepatocyte-like and biliary-like cells. Differentiated HepaRG cultures maintain key hepatic functions including drug transporters and xenobiotic-metabolizing enzymes. To gain insight into proliferative and differentiated HepaRG metabolism we profiled various bioenergetic parameters and investigated cell culture levels of adenosine triphosphate (ATP), lactate, and lactate dehydrogenase (LDH) activity. Compared to differentiated-derived HepaRG, cells from proliferative cultures had increased basal and ATP-linked respiration and decreased maximal and spare respiratory capacities. Basal ATP levels but not lactate or LDH activity were increased in samples from proliferative-derived compared to differentiated-derived HepaRG. Further …

Constitutional Liquidation, William Baude

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No abstract provided.

Reckless Juveniles, Kimberly Thomas

Articles

Modern doctrine and scholarship largely take it for granted that offenders should be criminally punished for reckless acts.1 Yet, developments in our understanding of human behavior can shed light on how we define and attribute criminal liability, or at least force us to grapple with the categories that have existed for so long. This Article examines recklessness and related doctrines in light of the shifts in understanding of adolescent behavior and its biological roots, to see what insights we might attain, or what challenges these understandings pose to this foundational mens rea doctrine. Over the past decade, the U.S. Supreme …

Context Oriented Software Middleware, Basel Magableh

Articles

This article proposes a new paradigm for building an adaptive middleware that supports software systems with self-adaptability and dependability. In this article, we wish to explore how far we can support the engineering of self- adaptive applications using a generic and platform-independent middleware architecture provided by non-specialised programming languages such as Context-Oriented Programming (COP), and Aspect-Oriented Programming (AOP), and not limited to a specific platform or framework. This gives the software developers the flexibility to construct a self-adaptive application using a generic and reusable middleware components that employ popular design patterns, instead of forcing the software developers to use a …