Digital Commons Network^™

Job's Justice, Arthur J. Jacobson

Articles

The essay proposes that the book of Job offers nothing less than the anticipation and critique of certain elements in the constitution of Athens, as we understand the constitution of Athens in the works of its principal philosophers.

Raman Spectroscopy In Nanomedicine: Current Status And Future Perspectives, Hugh Byrne, Mark Keating

Articles

Raman spectroscopy is a branch of vibration spectroscopy which is capable of probing the chemical composition of materials. Recent advances in Raman microscopy have added significantly to the range of applications which now extend from medical diagnostics to exploring interfaces between biological organisms and nanomaterials. In this review, Raman is introduced in a general context, highlighting some of the areas in which the technique has found success in the past, as well as some of the potential benefits it offers over other analytical modalities. The subset of Raman techniques which specifically probe the nanoscale, namely Surface Enhanced and Tip Enhanced …

Using Modelling And Simulation To Improve Elderly Care In Ireland: A Case Study, Mohamed Ragab, Wael Rashwan, Waleed Abo-Hamad, Amr Arisha

Articles

Health care services both globally and domestically - are encountering critical issues due to the increasing demand for services at the time of economic recession. Hospital performance is subject to many constraints, and planning is made more difficult by the complexity and uncertainty of demand. Population ageing is creating immense pressures on healthcare facilities across the world, leaving them struggling to cope with the growing demand for elderly healthcare services. Current demand-supply gaps result in prolonged waiting times for patients and substantial cost burdens for healthcare systems due to delayed discharges. This paper reports on a project that uses modelling …

Simulation-Based Framework To Improve Patient Experience In An Emergency Department, Waleed Abo-Hamad, Amr Arisha

Articles

The global economic crisis has a significant impact on healthcare resource provision worldwide. The management of limited healthcare resources is further challenged by the high level of uncertainty in demand, which can lead to unbalanced utilisation of the available resources and a potential deterioration of patient satisfaction in terms of longer waiting times and perceived reduced quality of services. Therefore, healthcare managers require timely and accurate tools to optimise resource utility in a complex and ever-changing patient care process. An interactive simulation-based decision support framework is presented in this paper for healthcare process improvement. Complexity and different levels of variability …

Exploring Supports Provided For Student Eportfolio Development In A Professional Development Context, Muireann Okeeffe

Articles

This small scale study aimed to explore and establish if support strategies implemented to enhance student ePortfolios were helpful to students and to identify useful ways of supporting ePortfolio development with future cohorts of students. This action research study was informed through focus group discussion and individual interviews with students.

The importance of reflection for the development professional practice and of creative abilities is discussed. The substantial benefits of creativity within education are investigated and characteristics of creativity that might be developed with students’ ePortfolios are revealed. Specifically this paper seeks to foster Crafts (2011) four characteristics of creativity, pluralities, …

Custom, General Principles And The Great Architect Cassese, Mary Fan

Articles

Major advances in international criminal law and procedure rose on the trusses of judicially elucidated sources of international law—custom and general principles. These sources depend on the crucial art of derivation advanced by the architect of modern international criminal justice, President Antonio Cassese. What has transformed international criminal justice into flourishing law able to address changing configurations of violence is the development of the art of finding law in the dark and wilds of murky unwritten norms. [para] President Cassese pioneered paths through a perilous bog. "[T]he law lives in persons," and to understand the law one must study the …

Immunoproteomics: The Key To Discovery Of New Vaccine Antigens Against Bacterial Respiratory Infections, Ruth Dennehy, Siobhan Mcclean

Articles

The increase in antibiotic resistance and the shortage of new antimicrobials to prevent difficult bacterial infections underlines the importance of prophylactic therapies to prevent infection by bacterial pathogens. Vaccination has reduced the incidence of many serious diseases, including respiratory bacterial infections. However, there are many pathogens for which no vaccine is available and some vaccines are not effective among all age groups or among immunocompromised individuals. Immunoproteomics is a powerful technique which has been used to identify potential vaccine candidates to protect against pathogenic bacteria. The combination of proteomics with the detection of immunoreactive antigens using serum highlights immunogenic proteins …

Role Of Polymeric Excipients On Controlled Release Profile Of Glipizide From Plga And Eudragit Rs 100 Nanoparticles, Pratap Naha, Hugh Byrne, Amulya Panda

Articles

Polylactic-co-glycolic acid (PLGA) 50:50 and Eudragit RS 100 nanoparticles entrapping glipizide along with excipients were prepared using single emulsion solvent evaporation method. The objective was to develop single oral dose glipizide nano particles for reducing blood sugar level in diabetes induced experimental animals. Incorporation of Polyethylene glycol (PEG) (0.5%), Hydroxypropyl methylcellulose (HPMC) (0.5%) and Tween 20 (0.5%) in the organic phase during particle formulation improved release profile of glipizide from the polymer particles. Entrapment efficiency of glipizide in all the polymeric formulations was around ~70 %. Around 80 % of glipizide was released from both PLGA and Eudragit …

Effects Of Salinity On The Toxicity Of Ionic Silver And Ag-Pvp Nanoparticles To Tisbe Battagliai And Ceramium Tenuicorne, Ailbhe Macken, Hugh Byrne, Kevin Thomas

Articles

The toxic effects of polyvinylpyrrolidone (PVP) coated silver nanoparticles (Ag-NP_PVP) and ionic Ag, to Tisbe battagliai (Tb) and Ceramium tenuicorne (Ct) were investigated and the usefulness of standardised marine guidelines for ENP risk assessment were assessed. The toxicity of Ag-NP_PVP [CtEC₅₀ = 26.6 µg/L, TbEC₅₀ = 7.9 µg/L] and Ag⁺ [CtEC₅₀ = 2312.2µg/L, Tb EC₅₀ = 90.9 µg/L] to both test species differed, with the silver ENPs being more toxic. In contrast to Ag⁺ the toxicity of Ag-NP_PVP increased significantly with increasing salinity, however, after thorough characterisation it was not …

Killing Them With Kindness: Examining "Consumer-Friendly" Arbitration Clauses After At&T; Mobility V. Concepcion, Myriam E. Gilles

Articles

The article focuses on the U.S. Supreme Court case AT&T Mobility LLC v. Concepcion, in which California's "Discover Bank rule" was struck by the Court under the Federal Arbitration Act, which was upheld by the California Supreme Court in the court case Discover Bank v. Superior Court. It provides information that the rule is a judge-made rule which depicts that class action waivers are unforceable in arbitration agreements if such agreements are mentioned in standard form consumer contracts.

Web-Based Interactive Video Vignettes Create A Personalized Active Learning Classroom For Introducing Big Ideas In Introductory Biology, Leslie Kate Wright, Dina L. Newman, Jean A. Cardinale, Robert Teese

Articles

The typical “flipped classroom” delivers lecture material in video format to students outside of class in order to make space for active learning in class. But why give students passive material at all? We are developing a set of high-quality online educational materials that promote active, hands-on science learning to aid in teaching of core concepts for introductory biology at the college level. Interactive video vignettes (IVVs) incorporate evidence based teaching strategies to address known areas of confusion for entering students. Each IVV includes a live action scenario with undergraduates investigating a biological problem with a realistic experiment that users …

G-Strands, Darryl Holm, Rossen Ivanov, James Percival

Articles

A G-strand is a map g(t,s): RxR --> G for a Lie group G that follows from Hamilton's principle for a certain class of G-invariant Lagrangians. The SO(3)-strand is the G-strand version of the rigid body equation and it may be regarded physically as a continuous spin chain. Here, SO(3)_K-strand dynamics for ellipsoidal rotations is derived as an Euler-Poincar'e system for a certain class of variations and recast as a Lie-Poisson system for coadjoint flow with the same Hamiltonian structure as for a perfect complex fluid. For a special Hamiltonian, the SO(3) …

Eight Stranded -Barrel And Related Outer Membrane Proteins: Role In Bacterial Pathogenesis., Siobhan Mcclean

Articles

Gram negative bacteria have evolved many mechanisms of attaching to and invading host epithelial and immune cells. In particular, many outer membrane proteins (OMPs) are involved in this initial interaction between the pathogen and their host. This review focuses on a number of small pore-forming OMPs that are all composed of eight-stranded b- barrel proteins and include members of the OmpA, OmpW and OmpX families of proteins. These proteins, together with the related OmpA-like peptidoglycan associated lipoproteins, are involved in interactions with host cells and are mediators of virulence. In many cases, these proteins interact with host immune cells and …

Value Divergence In Global Intellectual Property Law, J. Janewa Osei-Tutu

Articles

It is a challenge for the United States to adequately protect the interests of its intellectual property industries. It is particularly difficult to effectively achieve this objective when the interests of the United States are not in line with the social, cultural, and economic goals of other nations. Yet, as a major exporter of intellectual property protected goods, the United States has an interest in negotiating effective international intellectual property agreements that are perceived to be legitimate by the state signatories and their constituents. Focusing on value divergence, this Article contributes to the growing body of literature on developing a …

Hyperspectral Imaging For Non-Contact Analysis Of Forensic Traces, Patrick J. Cullen, G. Edelman, T. Van Leeuwen, M. Aalders, E. Gaston

Articles

Hyperspectral imaging (HSI) integrates conventional imaging and spectroscopy, to obtain both spatial and spectral information from a specimen. This technique enables investigators to analyze the chemical composition of traces and simultaneously visualize their spatial distribution. HSI offers significant potential for the detection, visualization, identification and age estimation of forensic traces. The rapid, non-destructive and non-contact features of HSI mark its suitability as an analytical tool for forensic science. This paper provides an overview of the principles, instrumentation and analytical techniques involved in hyperspectral imaging. We describe recent advances in HSI technology motivating forensic science applications, e.g. the development of portable …

Horses For Discourses?: The Transition From Oral To Broadside Narrative In “Skewball”, Seán Ó Cadhla

Articles

The well-known horse-racing ballad ‘Skewball’ (hereafter, SB) has a well-established oral tradition in Ireland, with versions documented throughout the eighteenth-,nineteenth- and twentieth-centuries. The latest is a 1979 field-recording of Derry folksinger and storyteller, Eddie Butcher (Shields 2011:58-9). The ballad was also assimilated into African-American oral tradition, in which it was reconstructed and renamed ‘Stewball’ (Scarborough 1925:61-4; Lomax 1994:68-71), and was still being documented in American folk tradition as late as the 1930s (Flanders 1939:172-4). In common with countless other folk songs, SB was appropriated by broadside printers and subsequently enjoyed widespread public appeal throughout England in the early- to …

Genetics Of Sle: Functional Relevance For Monocytes/Macrophages In Disease, Jennifer C. Byrne, Joan Ní Gabhann, Elisa Lazzari, Rebecca Mahony, Siobhán Smith, Kevin Stacey, Claire Wynne, Caroline A. Jefferies

Articles

Genetic studies in the last 5 years have greatly facilitated our understanding of how the dysregulation of diverse components of the innate immune system contributes to pathophysiology of SLE. A role for macrophages in the pathogenesis of SLE was first proposed as early as the 1980s following the discovery that SLE macrophages were defective in their ability to clear apoptotic cell debris, thus prolonging exposure of potential autoantigens to the adaptive immune response. More recently, there is an emerging appreciation of the contribution both monocytes and macrophages play in orchestrating immune responses with perturbations in their activation or regulation leading …

Assessing A Young Writer’S Story, Julie Patterson

Articles

Now that's a story! Find out what this 1st grader is doing well and what our writer-in-residence would teach next.

Students Fail To Transfer Knowledge Of Chromosome Structure To Topics Pertaining To Cell Division, Dina L. Newman, Christina M. Catavero, Leslie Kate Wright

Articles

Cellular processes that rely on knowledge of molecular behavior are difficult for students to comprehend. For example, thorough understanding of meiosis requires students to integrate several complex concepts related to chromosome structure and function. Using a grounded theory approach, we have unified classroom observations, assessment data, and in-depth interviews under the theory of knowledge transfer to explain student difficulties with concepts related to chromosomal behavior. In this paper, we show that students typically understand basic chromosome structure but do not activate cognitive resources that would allow them to explain macromolecular phenomena (e.g., homologous pairing during meiosis). To improve understanding of …

The Embedded Epistemologist: Dispatches From The Legal Front, Susan Haack

Articles

In ordinary circumstances, we can assess the worth of evidence well enough without benefit of any theory; but when evidence is especially complex, ambiguous, or emotionally disturbing-as it often is in legal contexts-epistemological theory may be helpful. A legal fact-finder is asked to determine whether the proposition that the defendant is guilty, or is liable, is established to the required degree of proof by the [admissible] evidence presented; i.e., to make an epistemological appraisal. The foundherentist theory developed in Evidence and Inquiry can help us understand what this means; and reveals that degrees of proof cannot be construed as mathematical …

Dimethylsulfoxide Exposure Modulates Hl-60 Cell Rolling Interaction, David Gee, Leslie Kate Wright, Jonathan Zimmerman, Kayla Cole, Karen Soule, Michelle Ubowski

Articles

Human leukaemic HL-60 cells are widely used for studying interactions involving adhesion molecules [e.g. P-selectin and PSGL-1 (P-selectin glycoprotein ligand-1)] since their rolling behaviour has been shown to mimic the dynamics of leucocyte rolling in vitro. HL-60 cells are neutrophilic promyelocytes that can undergo granulocytic differentiation upon exposure to compounds such as DMSO (dimethylsulfoxide). Using a parallel plate flow chamber functionalized with recombinant P-selectin–Fc chimaera, undifferentiated and DMSO-induced (48, 72 and 96 h) HL-60 cells were assayed for rolling behaviour. We found that depending on P-selectin incubation concentration, undifferentiated cells incurred up to a 6-fold increase in rolling velocity while …

Interaction Of Environmental B. Cenocepacia Strains With Cystic Fibrosis And Non-Cystic Fibrosis Bronchial Epithelial Cells In Vitro., Annamaria Bevivino, Luisa Pirone, Ruth Pilkington, Noemi Cifani, Claudia Dalmastri, Máire Callaghan, Fiorentina Ascenzioni, Siobhan Mcclean

Articles

Burkholderia cenocepacia is an important human pathogen in patients with cystic fibrosis (CF). Non-clinical reservoirs may play a role in the acquisition of infections, so it is important to evaluate the pathogenic potential of environmental B. cenocepacia isolates. In this study, we investigated the interactions of two environmental B. cenocepacia strains (Mex1 and MCII-168) with two bronchial epithelial cell lines,16HBE14o- and CFBE41o-, which have a non-CF and a CF phenotype, respectively.

The environmental strains showed a significantly lower level of invasion into both CF- and non-CF cells in comparison with the clinical B. cenocepacia LMG16656^T strain. Exposure of polarized …

Designing And Implementing A Platform For Collecting Multi-Modal Data Of Human-Robot Interaction, Brian Vaughan, Jing Guang Han, Emer Kilmartin, Nick Campbell

Articles

This paper details a method of collecting video and audio recordings of people inter- acting with a simple robot interlocutor. The interaction is recorded via a number of cameras and microphones mounted on and around the robot. The system utilised a number of technologies to engage with interlocutors including OpenCV, Python, and Max MSP. Interactions over a three month period were collected at The Science Gallery in Trinity College Dublin. Visitors to the gallery freely engaged with the robot, with interactions on their behalf being spontaneous and non-scripted. The robot dialogue was a set pattern of utterances to engage interlocutors …

Binding The Executive (By Law Or By Politics), Aziz Huq

Articles

No abstract provided.

Impaired Clearance And Enhanced Pulmonary Inflammatory/Fibrotic Response To Carbon Nanotubes In Myeloperoxidase-Deficient Mice, Aidan Meade, Anna Shvedova, Alexandr Kapralov, Wei Hong Feng, Elena Kisin, Ashley Murray, Robert Mercer, Claudette St. Croix, Megan Lang, Simon Watkins, Nagarjun Konduru, Brett Allen, Jennifer Conroy, Gregg Kotchey, Bashir Mohamed, Yuri Volkov, Alexander Star, Bengt Fadeel, Valerian Kagan

Articles

Advancement of biomedical applications of carbonaceous nanomaterials is hampered by their biopersistence and proinflammatory action in vivo. Here, we used myeloperoxidase knockout B6.129X1-MPO (MPO k/o) mice and showed that oxidation and clearance of single walled carbon nanotubes (SWCNT) from the lungs of these animals after pharyngeal aspiration was markedly less effective whereas the inflammatory response was more robust than in wild-type C57Bl/6 mice. Our results provide direct evidence for the participation of MPO – one of the key-orchestrators of inflammatory response – in the in vivo pulmonary oxidative biodegradation of SWCNT and suggest new ways to control the biopersistence of …

What Is The Pensee Sauvage And Is It Still Alive In Modern Society?, Mark William Farrell

Articles

The culinary process has changed somewhat down through the ages but not to any great extent. The raw materials are still similar but innovation and creativity has been applied to them to give the finished product varying degrees of taste, texture, sensory and aesthetic pleasure. Fundamentally the tools which we use to interpret or rate our food are the very same apparatus which animals use to define theirs. The anthropology of sensory perception is essentially the same for animals and man in an evolutionary perspective (Pasquet, Simmen & Pagezy, 2000). It reflects the capacity of the animal or primitive human …

Physicochemical And Microbiological Quality Of Harvested Rainwater From An Agricultural Installation In Ireland, Sean O'Hogain, Liam Mccarton, Niamh Mcintyre, Jenny Pender, Anna Reid

Articles

Members of DTC Research Group. Dublin Institute of Technology was commissioned in 2005 by the Department of Environment, Heritage and Local Government in Ireland to assess the feasibility of utilising rainwater to replace treated mains water for nonpotable uses. The project involved the design, installation, commissioning and monitoring of rainwater harvesting on a farm. Two monitoring programmes, Regime 1 and Regime 2, examined the physicochemical and microbiological quality of the harvested rainwater. Samples were taken monthly and tested. Regime 1 analysis showed that the microbiological quality of the rainwater from the site did not comply with the requirements of the …

Can Design Thinking Have A Social Life Through Networking?, Brenda Duggan

Articles

‘The design process is best described metaphorically as a system of spaces rather than a predefined series of orderly steps. The steps demarcate different sorts of related activities that together form a continuum of innovation’. (Brown, 2008, 4) This paper addresses two different spaces for examining design thinking — the design research notebook and the digital space, the topic-driven blog. The premise for this paper arises from teaching digital media on a visual communication programme. I wanted to ask the question from my perspective as an educator — if the individual research notebook is a convention or vehicle for design …

Word And Place In Irish Typography, Brian Dixon

Articles

Toponomic typography, or place-name typography, is not, in any sense a formal discipline. It is, however, common for typographers to find themselves setting the names of locations and settlements within a diverse range of projects. Wayfinding solutions, public transport information material and road signage are but some examples of the instances in which the designer is required to represent and visually interpret those words which mean so much to so many.

Motionless Monotony: New Nowheres In Irish Photography, Colin Graham

Articles

‘But my mind was too confused … so with a kind of madness growing upon me, I flung myself into futurity … What strange developments of humanity, what wonderful advances upon our rudimentary civilization, I thought, might not appear when I came to look into the dim elusive world that raced and fluctuated before my eyes. I saw great and splendid architecture rising about me, more massive than any buildings of our own time, and yet, it seemed, built of glimmer and mist … the earth seemed very fair. And so my mind came round to the business of stopping.’ …