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All Graduate Theses and Dissertations, Spring 1920 to Summer 2023

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Preventative Behavioral Parent Training: A Preliminary Investigation Of Strategies For Preventing At-Risk Children From Developing Later Conduct Problems, Jessica L. Malmberg May 2011

Preventative Behavioral Parent Training: A Preliminary Investigation Of Strategies For Preventing At-Risk Children From Developing Later Conduct Problems, Jessica L. Malmberg

All Graduate Theses and Dissertations, Spring 1920 to Summer 2023

Children exhibiting conduct problems comprise the largest source of referrals to children's mental health services in this county. Significant research has been conducted in an attempt to identify specific risk factors that result in increased vulnerability of a child developing conduct problems. Knowledge of these factors increases our ability to identify young children who are at greater risk for developing conduct problems. The treatment for conduct problems that possesses the greatest amount of empirical support is behavioral parent training. Yet behavioral parent training fails to address behaviors and risk factors that are present during a child's early development. Preventative behavioral …


Graph Kernels And Applications In Bioinformatics, Marco Alvarez Vega May 2011

Graph Kernels And Applications In Bioinformatics, Marco Alvarez Vega

All Graduate Theses and Dissertations, Spring 1920 to Summer 2023

Nowadays, machine learning techniques are widely used for extracting knowledge from data in a large number of bioinformatics problems. It turns out that in many of such problems, data observations can be naturally represented by discrete structures such as graphs, networks, trees, or sequences. For example, a protein can be seen as a cloud of interconnected atoms lying on a 3-dimensional space. The focus of this dissertation is on the development and application of machine learning techniques to bioinformatics problems wherein the data can be represented by graphs. In particular, we focus our attention on proteins, which are essential elements …


The Effect Of Stream Restoration On Preferred Cutthroat Trout Habitat In The Strawberry River, Utah, Nicolas R. Braithwaite May 2011

The Effect Of Stream Restoration On Preferred Cutthroat Trout Habitat In The Strawberry River, Utah, Nicolas R. Braithwaite

All Graduate Theses and Dissertations, Spring 1920 to Summer 2023

Stream restoration has become a popular management tool for attempting to increase and/or restore fish populations by improving habitat. A section of the Strawberry River, Utah recently underwent a stream restoration project, where the main goals of the project included increasing spawning activity, rearing potential, and resident populations of Bear Lake cutthroat trout Oncorhynchus clarkia utah. The impact of the restoration project on cutthroat trout was investigated by first characterizing preferred habitat for different life stages, investigating habitat as a limiting factor in the system, and then assessing the quality of available habitat by comparing restored/unrestored sections of stream …


Invertebrate Community Changes Along Coqui Invasion Fronts In Hawaii, Ryan T. Choi May 2011

Invertebrate Community Changes Along Coqui Invasion Fronts In Hawaii, Ryan T. Choi

All Graduate Theses and Dissertations, Spring 1920 to Summer 2023

The Puerto Rican coqui frog, Eleutherodactylus coqui, was introduced to Hawaii in the late 1980s via the commercial horticulture trade. Previous research has shown that coquis can change invertebrate communities, but these studies were conducted at small scales using controlled, manipulative experiments. The objective of this research was to determine whether coqui invasions change invertebrate communities at the landscape scale across the island of Hawaii. At each invasion front, we measured environmental variability on either side of the front and removed sites that were too variable across the front to ensure that the impacts we measured were the result …


What Classroom Observations Reveal About Primary Grade Reading Comprehension Instruction Within High Poverty Schools Participating In The Federal Reading First Initiative, Rebecca S. Donaldson May 2011

What Classroom Observations Reveal About Primary Grade Reading Comprehension Instruction Within High Poverty Schools Participating In The Federal Reading First Initiative, Rebecca S. Donaldson

All Graduate Theses and Dissertations, Spring 1920 to Summer 2023

Reading comprehension is one of the most critical academic skills to be acquired in school; therefore, the comprehension instruction provided by teachers is of utmost importance. This study examined 3 years of classroom observation data to describe the comprehension instruction provided by kindergarten through third-grade teachers who were participating in the federal Reading First reading reform initiative within 22 high-poverty Title I schools located in rural, suburban, and urban school districts in one western state. An explanatory sequential mixed-methods design was used to analyze data collected during 325 three-hour observations of classroom literacy instruction to identify both the quantity and …


Ecology And Conservation Of Cougars In The Eastern Great Basin: Effects Of Urbanization, Habitat Fragmentation, And Exploitation, David C. Stoner May 2011

Ecology And Conservation Of Cougars In The Eastern Great Basin: Effects Of Urbanization, Habitat Fragmentation, And Exploitation, David C. Stoner

All Graduate Theses and Dissertations, Spring 1920 to Summer 2023

This research was designed to investigate cougar response to urbanization, habitat fragmentation, and exploitation from behavioral, demographic, and landscape perspectives. The source-sink model has been proposed as an alternative framework for the management of exploited cougar populations. I addressed the basic question of whether cougars conform behaviorally to the predictions of the source-sink model, and consequently, the applied question of whether the model could be used for the conservation of this species. To achieve this I evaluated three scale-specific questions using radio-telemetry and hunter-harvest data collected from 1996-2010. At the subpopulation scale, I tested the hypothesis that cougars are wildland …


Establishing Weed Prevention Areas And Evaluating Their Impact, Stephanie Christensen May 2011

Establishing Weed Prevention Areas And Evaluating Their Impact, Stephanie Christensen

All Graduate Theses and Dissertations, Spring 1920 to Summer 2023

The spread of invasive weeds continues to be a serious economic and environmental threat. Weed prevention has the potential to stop weeds before they become well established in an area conserving time, energy, and resources. Unfortunately, weed prevention is often overlooked. Weed Prevention Areas (WPAs) are a relatively new tool developed to help improve the application of weed prevention. They are cooperatively managed areas that focus on implementing prevention and early detection strategies at a community level. The purpose of this research was to establish baseline data that will be used to evaluate the overall effectiveness of the WPA concept, …


Upper-Class Adolescent Delinquency: Theory And Observation, Nick Marsing May 2011

Upper-Class Adolescent Delinquency: Theory And Observation, Nick Marsing

All Graduate Theses and Dissertations, Spring 1920 to Summer 2023

Delinquency in adolescence has captured the imagination of thinkers and researchers for generations. In this thesis, a unique segment of adolescent delinquency is examined: delinquency in upper-class adolescents. My experience working in residential treatment centers was a catalyst for this research and inspired the primary question which guides the work: "Why would upper-class adolescents commit delinquent acts?" In an attempt to answer this question, the "Big Three" (strain, control, and social learning) sociological theories of crime and delinquency are used to explore upper-class or "elite" delinquency. After examining each theory I demonstrate how none of them, individually, can adequately explain …


Fluoro-Silane As A Functional Monomer For Protein Conformational Imprinting, Yun Peng May 2011

Fluoro-Silane As A Functional Monomer For Protein Conformational Imprinting, Yun Peng

All Graduate Theses and Dissertations, Spring 1920 to Summer 2023

By using the technology of molecularly imprinted polymer (MIP), we propose to synthesize a protein conformational imprint that also acts as a plastic enzyme, inducing protein structural transitions. The imprint aims at MIP-induced stabilization and / or formation of bound protein secondary structure and the applications associated with analysis and correction of misfolded proteins. The screening of polymeric functional monomers being able to induce the conformational transitions in proteins is investigated in this report.

The fluoro-silanes (3-heptafluoroisopropoxy)propalethoxysilane (7F) and 3,3,3-trifluoropropylmethoxysilane (3F) were employed as functional monomers for synthesis of this catalytic protein conformational imprint via sol-gel reactions. 3F was demonstrated …


The Relationship Between Coaching Mentors, Age, And Adolescent Problem Behaviors, Derek J. Hoke May 2011

The Relationship Between Coaching Mentors, Age, And Adolescent Problem Behaviors, Derek J. Hoke

All Graduate Theses and Dissertations, Spring 1920 to Summer 2023

This study examined coaches as potential mentors who could influence adolescent problem behaviors. By using the National Longitudinal Study of Adolescent Health (Add Health), this study compared adolescents who self-reported not having any adult mentors in their life against adolescents who self-reported having a coach mentor in their life on various problem behaviors (i.e., sexual attitudes and behaviors, tobacco, marijuana, steroid, and alcohol use). This study also looked ages of adolescents to see what, if any, influences age presented. Results of this study indicated that in some areas coaches might have a positive effect, albeit slight. When age was analyzed …


Evaluating Reliability And Validity Evidence For Merrill's 2007 5 Star Instrument, Max Hale Cropper May 2011

Evaluating Reliability And Validity Evidence For Merrill's 2007 5 Star Instrument, Max Hale Cropper

All Graduate Theses and Dissertations, Spring 1920 to Summer 2023

Merrill’s 2007 5 Star instrument, hereafter called the M-5 Star, is based on Merrill’s well recognized First Principles of Instruction. However, the instrument has not been tested for reliability and validity. In a pilot study, Cropper’s version of his instrument (C-5 Star) showed some reliability and validity evidence, but the M-5 Star needed similar evidence. To address this gap in the literature, the purpose of this study is to assess the reliability and validity evidence for M-5 Star. Raters were drawn from a graduate course in online course evaluation and asked to rate a sample (N = 6) of …


The Decline And Conservation Status Of North American Bumble Bees, Jonathan Berenguer Koch May 2011

The Decline And Conservation Status Of North American Bumble Bees, Jonathan Berenguer Koch

All Graduate Theses and Dissertations, Spring 1920 to Summer 2023

Several reports of North American bumble bee (Bombus Latreille) decline have been documented across the continent, but no study has fully assessed the geographic scope of decline. In this study I discuss the importance of Natural History Collections (NHC) in estimating historic bumble bee distributions and abundances, as well as in informing current surveys. To estimate changes in distribution and relative abundance I compare historic data assembled from a >73,000 specimen database with a contemporary 3-year survey of North American bumble bees across 382 locations in the contiguous U.S.A. Based on my results, four historically abundant bumble bees, B. …


Causes, Extent, And Consequences Of Lead-Pellet Ingestion By Chukars (Alectoris Chukar) In Western Utah: Examining Habitat, Search Images, And Toxicology, R. Justin Bingham May 2011

Causes, Extent, And Consequences Of Lead-Pellet Ingestion By Chukars (Alectoris Chukar) In Western Utah: Examining Habitat, Search Images, And Toxicology, R. Justin Bingham

All Graduate Theses and Dissertations, Spring 1920 to Summer 2023

Lead ingestion adversely affects humans and over 130 species of wildlife. Wild chukars (Alectoris chukar) are documented to ingest lead, but the causes and consequences of this ingestion are poorly understood. The objectives of this research were to 1) examine the influence of habitat use, the hunting season, and seasonal climate on the extent and severity of lead ingestion by chukars in western Utah, 2) assess the effects of habitat use, feeding behaviors, and lead density on the causes of lead-pellet ingestion in captive and wild chukars, and 3) investigate the consequences of lead-pellet ingestion in captive chukars as a …


Historical Biogeography Of Velvet Ants (Hymenoptera: Mutillidae) In The North American Deserts And Arid Lands, Joseph S. Wilson Dec 2010

Historical Biogeography Of Velvet Ants (Hymenoptera: Mutillidae) In The North American Deserts And Arid Lands, Joseph S. Wilson

All Graduate Theses and Dissertations, Spring 1920 to Summer 2023

For centuries, scientists have been intrigued by the high amount of biodiversity that is found in the deserts of North America. Recently, several studies have investigated the causes of the high diversity found in desert-dwelling mammals, reptiles, and amphibians. These studies have found that many of these organisms seem to have diversified in response to the same historical events. Little work has been done, however, on diverse desert-dwelling insect groups. In this dissertation, I investigate the patterns of genetic diversity in four groups of nocturnal wasps called velvet ants. I compare the patterns of genetic diversity to the historical events …


Spatial Light Dilution As A Technique For Conversion Of Solar Energy To Algal Biomass, Daniel J. Dye Dec 2010

Spatial Light Dilution As A Technique For Conversion Of Solar Energy To Algal Biomass, Daniel J. Dye

All Graduate Theses and Dissertations, Spring 1920 to Summer 2023

A photobioreactor has been designed and developed to efficiently utilize solar irradiance through spatial dilution of sunlight. The concept of spatial light dilution is simple: incident sunlight is spread over a large surface area, thus reducing the photon flux density of the light. The implementation of this technique, however, is difficult. The reactor described within uses a new approach to spatial light dilution, utilizing recently-developed optical components to diffuse concentrated sunlight inside an algae culture. Preliminary productivity tests indicate a 2-3 fold increase in productivity per unit aperture (sunlight collection area) over a control reactor with direct-sunlight. Aperture productivity of …


Kinetic, Mechanistic, And Structural Investigation Of Features Controlling Stereoselectivity Of (R)- And (S)-Hydroxypropyl Com Dehydrogenases From Xanthobacter Autrophicus Strain Py2, Dariusz Adam Sliwa Dec 2010

Kinetic, Mechanistic, And Structural Investigation Of Features Controlling Stereoselectivity Of (R)- And (S)-Hydroxypropyl Com Dehydrogenases From Xanthobacter Autrophicus Strain Py2, Dariusz Adam Sliwa

All Graduate Theses and Dissertations, Spring 1920 to Summer 2023

Enantiopure alcohols are valuable intermediates in fine organic synthesis, in particular for preparation of biologically active compounds. The necessity of preparing single enantiomer drugs in an optically pure form has triggered much research, especially in the pharmaceutical industry. The biocatalytical production of chiral alcohols by alcohol dehydrogenase enzymes is characterized by the asymmetric reduction of the corresponding ketones, usually with high degree of stereoselectivity. The commercial value of the enzymes as stereoselective biocatalysts has been a significant driving force in understanding features that control their mechanism of catalysis and stereoselectivity. This work focuses on two enantiocomplementary dehydrogenase enzymes ((R …


Clarifying The Relationship Between Emotion Regulation, Gender, And Depression, Emi Sumida Dec 2010

Clarifying The Relationship Between Emotion Regulation, Gender, And Depression, Emi Sumida

All Graduate Theses and Dissertations, Spring 1920 to Summer 2023

This study investigates the relation between emotion regulation problems and clinical depression. One goal of the present study was to bring increased clarity and parsimony to how emotion regulation is presently measured by consolidating three widely used instruments. In addition, of interest was an investigation of whether particular emotion regulation problems and management strategies interact with gender to predict either severity of overall depression symptoms or the presence of a formal mood disorder diagnosis. The results clearly showed that irrespective of a person's gender, particular emotion regulation indicators, both singly, and in combination, are, indeed, more strongly related to the …


The State Of Integrated Open Space Planning: Toward Landscape Integrity?, Lindsay Ex Dec 2010

The State Of Integrated Open Space Planning: Toward Landscape Integrity?, Lindsay Ex

All Graduate Theses and Dissertations, Spring 1920 to Summer 2023

Open space planning has been present within the United States for over a century. Traditionally, open space planning efforts tend to focus more exclusively on either socially-based (e.g., recreational, scenic, or park planning) or ecologically-based (e.g., preserves, habitat networks or more general conservation planning) planning efforts. This separation of ecological and social frameworks in open space planning is reinforced by a persistent cultural model, where community and conservation are seen as opposing forces instead of partners.

While recent open space planning efforts have begun to integrate social and ecological frameworks into one plan, the majority of our knowledge on integrated …


Bosom Buddies: Factors Associated With Experiences Of Passionate Friendship Among Men And Women, Katherine A. Peterson Dec 2010

Bosom Buddies: Factors Associated With Experiences Of Passionate Friendship Among Men And Women, Katherine A. Peterson

All Graduate Theses and Dissertations, Spring 1920 to Summer 2023

Scholars historically have separated friendships and romantic relationships into two qualitatively distinct relationship categories. Contemporary research examining passionate friendships, however, has identified qualities within platonic relationships that appear to mimic characteristics typically associated with romantic relationships. Primary critiques of the existing passionate friendship literature include exclusively examining females, including samples that predominately identified as lesbian, bisexual or questioning, and research utilizing solely qualitative designs.

The current study used a quantitative design to investigate 375 emerging adults' (18-26 years of age; 149 males, 226 females) friendship experiences. Specifically, four quasi-independent variables (i.e., biological sex, sexual orientation, gender-role orientation, and cross vs. …


Assessing Linkages Among Landscape Characteristics, Stream Habitat, And Macroinvertebrate Communities In The Idaho Batholith Ecoregion, Andrew C. Hill Dec 2010

Assessing Linkages Among Landscape Characteristics, Stream Habitat, And Macroinvertebrate Communities In The Idaho Batholith Ecoregion, Andrew C. Hill

All Graduate Theses and Dissertations, Spring 1920 to Summer 2023

Understanding the composition of lotic communities and the landscape processes and habitat characteristics that shape them is one of the main challenges confronting stream ecologists. In order to better understand the linkages among landscape processes, stream habitat, and biological communities and to understand how accurately our measurements represent important factors influencing biological communities, it is important to test explicit hypotheses regarding these linkages. Increasing our understanding of aquatic communities in a hierarchical context and recognizing how well our measurements represent factors structuring aquatic communities will help managers better evaluate the influence of land management practices on aquatic ecosystems, direct conservation …


Integration Of Ultrasonic Consolidation And Direct-Write To Fabricate An Embedded Electrical System Within A Metallic Enclosure, Ludwing A. Hernandez Dec 2010

Integration Of Ultrasonic Consolidation And Direct-Write To Fabricate An Embedded Electrical System Within A Metallic Enclosure, Ludwing A. Hernandez

All Graduate Theses and Dissertations, Spring 1920 to Summer 2023

A research project was undertaken to integrate Ultrasonic Consolitation (UC) and Direct-Write (DW) technologies into a single apparatus to fabricate embedded electrical systems within an ultrasonically consolidated metallic enclosure. Process and design guidelines were developed after performing fundamental research on the operational capabilities of the implemented system. In order to develop such guidelines, numerous tests were performed on both UC and DW. The results from those tests, as well as the design and process guidelines for the fabrication of an embedded touch switch, can be used as a base for future research and experimentation on the UC-DW apparatus. The successful …


Finances In Strong African American Marriages, Bonnie Lichfield Anderson Dec 2010

Finances In Strong African American Marriages, Bonnie Lichfield Anderson

All Graduate Theses and Dissertations, Spring 1920 to Summer 2023

This study focused on how African American couples in happy marriages talked about finances in their couple relationships. Qualitative methodology was used for this study, and the data came from transcribed interviews with participants. Thirty-seven couples who identified their marriages as being strong, happy, or highly satisfying, volunteered to be interviewed for this study. All individual participants (74 total) talked about finances in their marriages, and all interviews were used for the purpose of this study. Their descriptions were coded and analyzed to explore the way that they talked about money issues in their marriages. The research questions focused on …


Environmental And Developmental Indicators In Early Childhood: Relations To Second-Grade Reading Comprehension, Gina A. Cook Dec 2010

Environmental And Developmental Indicators In Early Childhood: Relations To Second-Grade Reading Comprehension, Gina A. Cook

All Graduate Theses and Dissertations, Spring 1920 to Summer 2023

Reading success has been linked to high school completion, future job success, and future generations of children who can read. Unfortunately, children who are unable to read on grade level by the end of first grade are at a great disadvantage and unlikely to catch up later. Without the ability to read and comprehend text, all aspects of schooling become progressively more difficult and the challenge of poor reading ability can be so difficult to overcome that many poor readers will not complete high school. For these reasons, it is important to identify early experiences in a child's family environment …


Native Bunchgrass And Invasive Weed Establishment In Low Nutrient Rangeland Soils With Nitrogen And Phosphorus Manipulation, Jeffrey S. Burnham Dec 2010

Native Bunchgrass And Invasive Weed Establishment In Low Nutrient Rangeland Soils With Nitrogen And Phosphorus Manipulation, Jeffrey S. Burnham

All Graduate Theses and Dissertations, Spring 1920 to Summer 2023

Competition between native perennial grasses and Bromus tectorum has been studied for many years. Recently, soil nutrients have been immobilized in an effort to preferentially inhibit growth of B. tectorum relative to native species. Most of this work has focused on soil N, but interactions with soil P are less studied and may be important as well. Additionally, although competitive effects and nutrient responses of several Centaurea spp. are well documented, data are lacking on the competitive effects that Centaurea virgata exerts on the establishment of native and exotic communities. A field experiment and a greenhouse experiment were conducted to …


Worry And Rumination: Measurement Invariance Across Gender, Janet A. Carter Dec 2010

Worry And Rumination: Measurement Invariance Across Gender, Janet A. Carter

All Graduate Theses and Dissertations, Spring 1920 to Summer 2023

The present study examined the factor structure of the Penn State Worry Questionnaire (PSWQ), the Student Worry Questionnaire-30 (SWQ-30), the Anxious Thoughts Inventory (AnTI), the Ruminative Responses Scale (RRS), and the Rumination-Reflection Questionnaire (RRQ). The present study also examined the measurement invariance between men (n = 186) and women (n = 316) in a university sample. Different models for each measure were identified through a review of the literature, and the models were examined through confirmatory factor analyses. The best-fitting models for each measure were retained for subsequent model modification to improve fit and for invariance testing across …


Architecture, Modeling, And Analysis Of A Plasma Impedance Probe, Magathi Jayaram Dec 2010

Architecture, Modeling, And Analysis Of A Plasma Impedance Probe, Magathi Jayaram

All Graduate Theses and Dissertations, Spring 1920 to Summer 2023

Variations in ionospheric plasma density can cause large amplitude and phase changes in the radio waves passing through this region. Ionospheric weather can have detrimental effects on several communication systems, including radars, navigation systems such as the Global Positioning Sytem (GPS), and high-frequency communications. As a result, creating models of the ionospheric density is of paramount interest to scientists working in the field of satellite communication.

Numerous empirical and theoretical models have been developed to study the upper atmosphere climatology and weather. Multiple measurements of plasma density over a region are of marked importance while creating these models. The lack …


Phenotypic And Genetic Characterization Of Wildland Collections Of Western And Searls Prairie Clovers For Rangeland Revegetation In The Western Usa, Kishor Bhattarai Dec 2010

Phenotypic And Genetic Characterization Of Wildland Collections Of Western And Searls Prairie Clovers For Rangeland Revegetation In The Western Usa, Kishor Bhattarai

All Graduate Theses and Dissertations, Spring 1920 to Summer 2023

Western prairie clover [Dalea ornata (Douglas ex Hook.) Eaton & J. Wright] is a perennial legume that occurs in the northern Great Basin, Snake River Basin, and southern Columbia Plateau, whereas Searls prairie clover [Dalea searlsiae (A. Gray) Barneby], also a perennial legume, occurs in the southern Great Basin and surrounding areas. Understanding the genetic and ecotypic variation of these prairie clovers is a prerequisite for developing populations suitable for rangeland revegetation in the western USA. DNA sequences of internal transcribed spacer (ITS/5.8S) and trnK/matK were used to study the phylogeny of these species. The species were distinguished …


An Evolutionary Approach To Optimization Of Compound Stock Trading Indicators Used To Confirm Buy Signals, Allan W. Teeples Dec 2010

An Evolutionary Approach To Optimization Of Compound Stock Trading Indicators Used To Confirm Buy Signals, Allan W. Teeples

All Graduate Theses and Dissertations, Spring 1920 to Summer 2023

This thesis examines the application of genetic algorithms to the optimization of a composite set of technical indicator filters to confirm or reject buy signals in stock trading, based on probabilistic values derived from historical data. The simplicity of the design, which gives each filter within the composite filter the ability to act independently of the other filters, is outlined, and the cumulative indirect effect each filter has on all the others is discussed. This system is contrasted with the complexity of systems from previous research that attempt to merge several indicator filters together by giving each one a weight …


The Effects Of Pedagogical Agents On Listening Anxiety And Listening Comprehension In An English As A Foreign Language Context, Young-Ah Ko Dec 2010

The Effects Of Pedagogical Agents On Listening Anxiety And Listening Comprehension In An English As A Foreign Language Context, Young-Ah Ko

All Graduate Theses and Dissertations, Spring 1920 to Summer 2023

This study aimed to explore the impact of pedagogical agents in computer-based listening instruction on EFL students' listening anxiety levels and listening comprehension skills. A total of 66 Korean college students received computer-based listening instruction. Students were randomly assigned to one of three conditions: American agent condition, Korean agent condition, or no-agent condition. Additional data sources were included in the experimental design in order to investigate students' learning experience more thoroughly.

Results indicated that there were no statistical differences in listening anxiety levels and listening comprehension skills between students who worked with the agent and students who worked without the …


Fat Taste Transduction In Mouse Taste Cells: The Role Of Transient Receptor Potential Channel Type M5, Pin Liu Dec 2010

Fat Taste Transduction In Mouse Taste Cells: The Role Of Transient Receptor Potential Channel Type M5, Pin Liu

All Graduate Theses and Dissertations, Spring 1920 to Summer 2023

A number of studies have demonstrated the ability of free fatty acids to activate taste cells and elicit behavioral responses consistent with there being a taste of fat. Here I show for the first time that long chain unsaturated free fatty acid, linoleic acid, depolarizes taste cells and elicits a robust intracellular calcium rise via the activation of transient receptor potential channel type M5. The linoleic acid-induced responses depend on G protein-phospholipase C pathway indicative of the involvement of G protein-coupled receptors in the transduction of fatty acids. Mice lacking transient receptor potential channel type M5 exhibit no preference for …