Open Access. Powered by Scholars. Published by Universities.®

Digital Commons Network™

Open Access. Powered by Scholars. Published by Universities.®

All Graduate Theses and Dissertations, Spring 1920 to Summer 2023

Discipline
Keyword
Publication Year

Articles 601 - 630 of 2824

Full-Text Articles in Entire DC Network

Anaerobic Co-Digestion Of Algal Biomass And A Supplemental Carbon Source Material To Produce Methane, Yousef Soboh May 2015

Anaerobic Co-Digestion Of Algal Biomass And A Supplemental Carbon Source Material To Produce Methane, Yousef Soboh

All Graduate Theses and Dissertations, Spring 1920 to Summer 2023

The demand on alternative energy is rapidly increasing because the reserves of conventional fuel are decreasing and their impacts on the environment are increasing.
Developing renewable energy sources should receive utmost attention. The production of biofuels like methanol, biodiesel, and methane from various kinds of abundant biomass represents a very attractive energy source that can reduce the dependence on conventional fossil fuels energy.

Since algae contains high amounts of nitrogen and low carbon content, this research focused on anaerobic fermentation of algae to produce methane by blending algae with a supplemental carbon source material, sodium acetate. This was done to …


Interactive Computer Simulation And Animation Learning Modules: A Mixed-Method Study Of Their Effects On Students' Problem Solving In Particle Dynamics, Yongquing Guo May 2015

Interactive Computer Simulation And Animation Learning Modules: A Mixed-Method Study Of Their Effects On Students' Problem Solving In Particle Dynamics, Yongquing Guo

All Graduate Theses and Dissertations, Spring 1920 to Summer 2023

Engineering dynamics is a fundamental core course in many undergraduate engineering curricula. This course is widely regarded as one of the most difficult engineering courses for students to succeed in. A variety of instructional strategies, such as hands-on experimentation, multimedia games, and computer simulation and animation (CSA), have been developed to improve student learning. Among these instructional strategies, CSA has been receiving increasing attention and applications in the international engineering education community. CSA provides students with a visualization tool and a constructivist environment to better understand various engineering problems.

The goal of this dissertation research was to improve student learning …


The Role Of Diet, Erythrocyte Membrane Fatty Acid Composition, And Alzheimer's-Related Genes In Systemic Inflammation In The Cache County Memory Study, Rola Adnan Jalloun May 2015

The Role Of Diet, Erythrocyte Membrane Fatty Acid Composition, And Alzheimer's-Related Genes In Systemic Inflammation In The Cache County Memory Study, Rola Adnan Jalloun

All Graduate Theses and Dissertations, Spring 1920 to Summer 2023

Alzheimer’s disease (AD) is the most common type of dementia in the elderly, accounting for 60 to 80% of all dementia cases. It affects 5.2 million Americans and 44 million worldwide. This project examines the association between dietary patterns, erythrocyte membrane fatty acids concentration, and AD-related genes in systemic inflammation as indicated by serum C-reactive protein (CRP). All studies performed in this project used the data collected in the Cache County Memory Study (CCMS).

Higher levels of accordance with the Dietary Approaches to Stop Hypertension (DASH) and Mediterranean dietary (MED) patterns were associated with consistently lower levels of CRP in …


The Effect Of Deposition From Static Rocket Tests On Immature Corn, Alfalfa, And Winter Wheat, Eric Curry May 2015

The Effect Of Deposition From Static Rocket Tests On Immature Corn, Alfalfa, And Winter Wheat, Eric Curry

All Graduate Theses and Dissertations, Spring 1920 to Summer 2023

ATK tests the performance of large solid rocket motors (SRMs) at their facility located in Promontory Point, Utah, USA. During these tests, an estimated 1.5 million kg (~3.3 million lbs.) of entrained soil and rocket exhaust are sent skyward in a cloud that can travel as far as 10-12 miles from the test site. As the cloud cools deposition known as Test Fire Soil (TFS) can settle on local crops. Farmers in the area have voiced concerns about the effects of TFS on their crops.

To address the concerns, I looked at the effect of a typical TFS deposition loading …


Effects Of Differential Rates Of Alternative Reinforcement On Resurgence Of Human Behavior: A Translational Model Of Relapse In The Anxiety Disorders, Brooke M. Smith May 2015

Effects Of Differential Rates Of Alternative Reinforcement On Resurgence Of Human Behavior: A Translational Model Of Relapse In The Anxiety Disorders, Brooke M. Smith

All Graduate Theses and Dissertations, Spring 1920 to Summer 2023

Brooke M. Smith, graduate student in the Combined Clinical, Counseling, and School Psychology program at Utah State University, proposed and completed this thesis in partial fulfillment of the requirements of Master of Science in Psychology.

Anxiety disorders are the most common psychological disorders in the world, and they place a substantial burden on society. Although successful psychological treatments for anxiety are available, many people still experience relapse once treatment ends. When consequences that follow a behavior increase its future probability, this is termed “reinforcement.” One common treatment approach for anxiety is to attempt to decrease problematic behavior, such as avoidance, …


Pregenomic And Genomic Effects Of 24,25-Dihydroxyvitamin D3, Yang Zhang May 2015

Pregenomic And Genomic Effects Of 24,25-Dihydroxyvitamin D3, Yang Zhang

All Graduate Theses and Dissertations, Spring 1920 to Summer 2023

In the United States, the major dietary source of protein is poultry meat, particularly chicken. Phosphorus absorption in chickens is a critical problem in poultry production. It therefore is important to understand the cellular and molecular regulation of phosphorous absorption in intestine to increase efficiency of the process. This would provide the benefits of reducing feed costs and reducing phosphorous excretion, thereby contributing to the sustainability of agriculture in the United States. Therefore, the focus of this thesis is determining the effect of vitamin D metabolites involved in phosphate homeostasis using the chicken as a model.


Biogeography, Population Genetics, And Community Structure Of North American Bumble Bees, Jonathan Berenguer Koch May 2015

Biogeography, Population Genetics, And Community Structure Of North American Bumble Bees, Jonathan Berenguer Koch

All Graduate Theses and Dissertations, Spring 1920 to Summer 2023

In 2011, several wild North American bumble bee pollinator species were reported to have declined by up to 96% in relative abundance in comparison to historic estimates, and one species was speculated to be extinct. None of these species have yet been documented to have recovered from these declines and additional species are now suggested to be at risk. Imperiled species in particular show increased specificity to narrow climatic envelopes, as opposed to putatively stable species. My dissertation describes patterns of population genetic diversity, structure, and gene flow pathways associated with climate variation and historical biogeography of bumble bees distributed …


An Exploratory Study Of Attributes, Affordances, Abilities, And Distance In Children's Use Of Mathematics Virtual Manipulative Ipad Apps, Stephen I. Tucker May 2015

An Exploratory Study Of Attributes, Affordances, Abilities, And Distance In Children's Use Of Mathematics Virtual Manipulative Ipad Apps, Stephen I. Tucker

All Graduate Theses and Dissertations, Spring 1920 to Summer 2023

This exploratory qualitative study investigated the presence of and relationships among constructs that contribute to children's interactions with educational technology, leading to the development of the modification of attributes, affordances, abilities, and distance (MAAAD) for Learning framework. For this study, each of 10 fifth-grade children participated in one individual video-recorded semistructured interview session, during which they interacted with two mathematics virtual manipulative iPad apps and responded to follow-up questions. Video recordings and observation field notes were analyzed for evidence of attributes, affordance-ability relationships, distance, and relationships among these constructs.

Constant comparative data analysis using memoing and eclectic coding provided evidence …


Price Slides Within Cattle Markets Over Time And Space, Justin Edward Dickamore May 2015

Price Slides Within Cattle Markets Over Time And Space, Justin Edward Dickamore

All Graduate Theses and Dissertations, Spring 1920 to Summer 2023

The production of cattle in the United State is a very large business. Production begins at the cow-calf level, where a calf is born and raised to a specific weight. This weight is the weaning weight and averages between 300-600 pounds. The calf is then typically shipped to a feedlot, where it is fed a high corn ration which increases the weight of animal quickly and cost effectively to reach a sufficient slaughter weight. Cattle production takes place primarily in 5 different geographical locations which include the North Central, Southeast, Northern Plains, Southern Plains, and West regions. Due to the …


Indicator 13 Training For Transition Teachers: Comparison Of Pre-And Post Test Scores On Writing Of Goals, Christina B. Smith May 2015

Indicator 13 Training For Transition Teachers: Comparison Of Pre-And Post Test Scores On Writing Of Goals, Christina B. Smith

All Graduate Theses and Dissertations, Spring 1920 to Summer 2023

Special education teachers sometimes experience problems with knowing how to construct and write transition goals that meet Indicator 13 requirements of the Individuals with Disabilities Education Act. This project examined the effects of teacher training in Indicator 13 requirements on the quality of transition goals. Participants included 17 special education teachers from one school district located in a western state. Target behaviors where increasing each participants’ post-test goal quality scores from individualized transition plans (ITP) written after they demonstrated knowledge about requirements through a post-instruction goal quality writing probe. Procedures involved (a) a pre examination of participants’ transition goals that …


Scalable Bio-Production Of High Value Products In Bacteria, Yukie Kawasaki May 2015

Scalable Bio-Production Of High Value Products In Bacteria, Yukie Kawasaki

All Graduate Theses and Dissertations, Spring 1920 to Summer 2023

Natural products are structurally and chemically diverse bioactive compounds produced by living organisms. The complex structures of natural products are often difficult to duplicate synthetically and thus industrial production of natural products most often depends on use of the host organisms. In this dissertation research, scalable production of natural products was pursued in bacterial platforms.

Biliverdin IXα is a natural anti-inflammatory compound which is emerging as a potent cytoprotectant in the medical field. Syringomycin E is a natural fungicide expected to be an effective agrofungicide in organic farming. Both biliverdin IXα and syringomycin E have limited supplies in the market. …


"It Is Not In The Stars To Hold Our Destiny But In Ourselves": Tales Of Saudi Muslim Women Maintaining Their Identities In U.S. Higher Education, Debi Sheridan May 2015

"It Is Not In The Stars To Hold Our Destiny But In Ourselves": Tales Of Saudi Muslim Women Maintaining Their Identities In U.S. Higher Education, Debi Sheridan

All Graduate Theses and Dissertations, Spring 1920 to Summer 2023

The objective of these oral histories was to examine, explain and reveal the success of a small group of Saudia (female Saudis) whose studies at a mid-Western American university through the medium of English (their second or third language). Four students were randomly selected from a group of volunteers, based on their successful completion of the English as a Second Language (ESL) program, plus a year of other academic classes in the university. One student, who had not completed the ESL program, was admitted to the master of English program having passed the Test of English as a Foreign Language …


Novel Techniques To Determine Soil Evaporation Rates: Heat Pulse Probe And Automated Microlysimeter, Kashifa Rumana May 2015

Novel Techniques To Determine Soil Evaporation Rates: Heat Pulse Probe And Automated Microlysimeter, Kashifa Rumana

All Graduate Theses and Dissertations, Spring 1920 to Summer 2023

Increase in world population rate has augmented the global water use in municipal, industrial, and agricultural sectors, with renewable water resources changing
very little with time. Climate change and variability, degradation of water quality as a result of industrial waste streams, animal manure and waste, application of chemicals, pesticides, pharmaceuticals, heavy metals, etc. have largely influenced the quantity and quality of soil water. Root zone water helps sustain the agricultural industry by providing much of the water needed for irrigation. It is critical to monitor the soil water availability, especially within the plant root zones. The subsurface water tends to …


A Translational Investigation Of Positive And Negative Behavioral Contrast, Megan A. Boyle May 2015

A Translational Investigation Of Positive And Negative Behavioral Contrast, Megan A. Boyle

All Graduate Theses and Dissertations, Spring 1920 to Summer 2023

Applied behavior analysts implement research-based techniques to improve behavior. However, research with nonhumans suggests that intervening to improve behavior in one context may result in a worsening of that same behavior in another context (behavioral contrast). Although there are clinical implications of behavioral contrast, the vast majority of research on contrast has been conducted with nonhuman animals. Results from basic research suggest that contrast is influenced differentially depending on whether a change in conditions follows versus precedes a given context. For example, a child might encounter three contexts each day: home, school, and daycare. An intervention to reduce the child’s …


Adoption, Adaptation, And Abandonment: Appropriation Of Science Education Professional Development Learning, Max L. Longhurst May 2015

Adoption, Adaptation, And Abandonment: Appropriation Of Science Education Professional Development Learning, Max L. Longhurst

All Graduate Theses and Dissertations, Spring 1920 to Summer 2023

Understanding factors that influence teachers to use certain practices from training they receive will help improve learning experiences for students. This study examined how two teachers with the same teacher training experience use learning from that training in their instruction differently. This research attempted to account for multiple factors that influenced teachers learning. Educator’s incorporation of teaching practices can vary from teacher to teacher and from training to training. This variability is understood in terms of their appropriation of new teaching practices into their teaching and delivery of learning. Two teachers were selected as a result of their participation in …


Ecology And Behavior Of Coyotes In Urban Environments At Varying Spatial Scales, Sharon A. Poessel May 2015

Ecology And Behavior Of Coyotes In Urban Environments At Varying Spatial Scales, Sharon A. Poessel

All Graduate Theses and Dissertations, Spring 1920 to Summer 2023

As urban development continues to increase throughout the world, wildlife species, including carnivores, will be affected either positively or negatively. Coyotes (Canis latrans) have learned to efficiently adapt to highly developed areas, and conflicts between humans and coyotes, such as attacks on humans and pets, are increasing. We conducted three studies of urban coyotes to understand the factors affecting habitat use by coyotes so that wildlife managers can reduce human-coyote conflicts. Each study was conducted at progressively larger scales, with the first study at a fine scale using captive coyotes, the second study at a local scale in the …


An Investigatory Study Of Relationships Among Selected Theoretical Components Of Letter-Writing Fluency, Pamela C. Reutzel May 2015

An Investigatory Study Of Relationships Among Selected Theoretical Components Of Letter-Writing Fluency, Pamela C. Reutzel

All Graduate Theses and Dissertations, Spring 1920 to Summer 2023

Research that shows the need for letter-writing fluency as a foundation for being able to attend to higher-level thinking skills in writing calls for more research as to what the components of letter-writing fluency actually are and how they are related to writing efficiency. To study the components of letter-writing fluency, four assessments were used to evaluate 49 kindergarten students’ letter writing abilities. These assessments were made in December of their kindergarten year. The first assessed subskill was letter-naming fluency (LNF), which has previously been shown to be predictive of reading ability. The other two subskills that were assessed focus …


Risk Characterization From Multipathway Exposure Associated With Land Applying Biosolids By Accounting For Multimedia Mass Loss, Karthik Kumarasamy May 2015

Risk Characterization From Multipathway Exposure Associated With Land Applying Biosolids By Accounting For Multimedia Mass Loss, Karthik Kumarasamy

All Graduate Theses and Dissertations, Spring 1920 to Summer 2023

There continues to be concern among communities living in the vicinity of biosolids land application sites about potential adverse health effects from the chemical contaminants present in biosolids. This study describes a procedure that will help answer questions about the risks involved in biosolids land application at the site level, thus, this study will provide a crucial communication tool for wastewater treatment facilities and biosolids land appliers to address the concerns of the public. Specifically, the study quantifies the exposure concentrations that a human being can become exposed to during their lifetime from the practice. Crucially, it takes a quantitate …


Clinician Recasts And Production Of Complex Syntax By Children With And Without Specific Language Impairment, Rebekah Wada May 2015

Clinician Recasts And Production Of Complex Syntax By Children With And Without Specific Language Impairment, Rebekah Wada

All Graduate Theses and Dissertations, Spring 1920 to Summer 2023

This study examined whether children with specific language impairment (SLI) respond differently than children who are typically developing in response to an intervention composed of the strategies of priming and recasting. Twenty-six children between the ages of 6 years, 10 months to 10 years, 11 months participated in the study (13 with SLI and 13 developing typically). The intervention was completed in one session. Findings revealed that both children with and without SLI were able to be primed to produce subject relative and object relative sentences with subject relative clauses being easier to produce than object relative clauses.


Concentrated Use Areas: Characteristics And Management Strategies On The Uinta-Wasatch-Cache National Forest, Zachary F. Maughan May 2015

Concentrated Use Areas: Characteristics And Management Strategies On The Uinta-Wasatch-Cache National Forest, Zachary F. Maughan

All Graduate Theses and Dissertations, Spring 1920 to Summer 2023

Outdoor recreation management has become common practice on public lands over the past century. The United States Forest Service (USFS) has been a leader in the category of recreation management during that time period as well. One management niche associated specifically with national forest land is the field of dispersed recreation. Within the field of dispersed recreation management, USFS staff address recreation use in a variety of ways. One such method has been the development of Concentrated Use Areas (CUAs) in dispersed recreation settings. These areas are generally defined as undeveloped recreation areas that sustain resource impacts and require management …


Microbial-Derived Oils And Value-Added Products: Biosynthesis And Applications For Biofuel Production, Alex T. Mccurdy May 2015

Microbial-Derived Oils And Value-Added Products: Biosynthesis And Applications For Biofuel Production, Alex T. Mccurdy

All Graduate Theses and Dissertations, Spring 1920 to Summer 2023

Efforts are being made to replace petroleum-derived fuels with biofuels in a cost competitive manner. It is apparent that the continued use of petroleum is futile as population and technological growth put increasing pressure on the demand for cheap energy and chemicals. Diminishing resources, civil unrest in the Middle East, and the impact of using petrochemicals on the environment are critical driving forces for research in generating renewable petroleum replacements that can be produced with a limited carbon-footprint. Today, biofuels are derived mostly from land-based plants, but their potential for displacing petroleum is limited due to the competition with available …


Representations Of Us Acts Of Extra-Territoriality As Illustrated In Pakistani-English Political Cartoons, Aina S. Niaz May 2015

Representations Of Us Acts Of Extra-Territoriality As Illustrated In Pakistani-English Political Cartoons, Aina S. Niaz

All Graduate Theses and Dissertations, Spring 1920 to Summer 2023

The significance of Pakistan as an international state cannot be downplayed. Not only is Pakistan the first Islamic state to develop its nuclear power, but Pakistan has served as an important geostrategic state to the US on several occasions. The US-Pakistan geopolitical relationship was most vividly highlighted during the final years of the Cold War; and has reemerged again in the Global War on Terror. This thesis will examine Pakistani-English political cartoons to examine the way US extra-territoriality is represented visually. Approximately 2940 political cartoons are collected from four Pakistani-English newspapers: Dawn, The Express Tribune, The Nation, …


Effect Of High Intensity Ultrasound On Crystallization Behavior And Functional Properties Of Lipids, Yubin Ye May 2015

Effect Of High Intensity Ultrasound On Crystallization Behavior And Functional Properties Of Lipids, Yubin Ye

All Graduate Theses and Dissertations, Spring 1920 to Summer 2023

The elimination of trans-fatty acids from food formulations has resulted in the search of new lipids and novel processing conditions that can provide optimum functional properties in fats while providing good nutritional properties. High intensity ultrasound (HIU) has been extensively studied on sonocrystallization of lipids since early 2000. Sonocrystallization refers to the induction of crystallization by HIU without generating any chemical changes. This dissertation aims to provide information on the effects of HIU on crystallization behavior and physical properties of different shortenings based on previous sonocrystallization research. Results in this dissertation showed that HIU successfully induced the crystallization of …


Factors Contributing To The Conservation Of Phacelia Submutica (Boraginaceae), A Threatened Species In Western Colorado: Reproductive Biology And Seed Ecology, Alicia M. Langton May 2015

Factors Contributing To The Conservation Of Phacelia Submutica (Boraginaceae), A Threatened Species In Western Colorado: Reproductive Biology And Seed Ecology, Alicia M. Langton

All Graduate Theses and Dissertations, Spring 1920 to Summer 2023

Conservation and recovery plans for rare species require biological and ecological information to discern how they may be susceptible to human disturbances. Phacelia submutica is a threatened annual species in western Colorado. Human activities including energy development, recreation, and livestock grazing are occurring within the species’ range. To provide conservation practitioners with a scientific basis for management, this research aimed to elucidate elements of the species’ ecology. Chapter 2 describes the reproductive biology of P. submutica. Potential insect pollinators were not observed during two years of observations. Floral traits and development ensure self-pollination and reduce the likelihood that insects …


Improvement Of Nutrient Utilization Efficiency, Ruminal Fermentation And Lactational Performance Of Dairy Cows By Feeding Birdsfoot Trefoil, Rachael G. Christensen May 2015

Improvement Of Nutrient Utilization Efficiency, Ruminal Fermentation And Lactational Performance Of Dairy Cows By Feeding Birdsfoot Trefoil, Rachael G. Christensen

All Graduate Theses and Dissertations, Spring 1920 to Summer 2023

Condensed tannins (CT) are compounds that have shown potential to reduce the environmental impact of dairy farming waste products. In two live animal studies and a continuous culture study, it was hypothesized that feeding birdsfoot trefoil (Lotus corniculatus, BFT), a CT-containing legume, would improve nutrient utilization, milk, and component yield of dairy cows compared with feeding alfalfa hay or grass pasture in two studies, while feeding BFT forage would decrease methane production and improve rumen fermentation in addition to concentrate supplementation was the hypothesis of the third study. Reduction in milk urea nitrogen (MUN) and …


Mechanical Properties Of Kenaf Composites Using Dynamic Mechanical Analysis, Thomas A. Loveless May 2015

Mechanical Properties Of Kenaf Composites Using Dynamic Mechanical Analysis, Thomas A. Loveless

All Graduate Theses and Dissertations, Spring 1920 to Summer 2023

Natural fibers show potential to replace glass fibers in thermoset and thermoplastic composites. Kenaf is a bast-type fiber with high specific strength and great potential to compete with glass fibers.

In this research kenaf/epoxy composites were analyzed using Dynamic Mechanical Analysis (DMA). A three-point bend apparatus was used in the DMA testing. The samples were tested at 1 hertz, at a displacement of 10 μm, and at room temperature.

The fiber volume content of the kenaf was varied from 20%-40% in 5% increments. Ten samples of each fiber volume fraction were manufactured and tested. The flexural storage modulus, the flexural …


Microhabitat Selection By Greater Sage-Grouse Hens In Southern Wyoming, Scott T. Mabray May 2015

Microhabitat Selection By Greater Sage-Grouse Hens In Southern Wyoming, Scott T. Mabray

All Graduate Theses and Dissertations, Spring 1920 to Summer 2023

Greater sage-grouse (Centrocercus urophasianus) populations have been declining throughout the western United States over the past 3 decades. Habitat loss within the range sagebrush steppe ecosystem is a major factor leading to sage-grouse population decline. Understanding the use of microhabitats by hen sage-grouse may provide data that will allow managers to reduce the decline in the sage-grouse population.

My objective was to determine the factors lead to site selection by hen sage-grouse hens. This was accomplished by addressing several questions regarding the interactions of habitat selection and predator avoidance among sage-grouse hens. I examined if (1) sites occupied …


Growth Performance, Ruminal Fermentation Characteristics, And Economic Returns Of Growing Beef Steers Fed Brown Midrib, Corn, Silage-Based Diet, Christopher Scott Saunders May 2015

Growth Performance, Ruminal Fermentation Characteristics, And Economic Returns Of Growing Beef Steers Fed Brown Midrib, Corn, Silage-Based Diet, Christopher Scott Saunders

All Graduate Theses and Dissertations, Spring 1920 to Summer 2023

Sustainable beef production is extremely important to the beef cattle industry. Sustainability influences the environment, overall profits, and public concerns. One
factor that influences sustainability is the composition of cattle feed. This study compared conventional corn silage (CCS), which is most commonly used in beef steer feed, to brown midrib corn silage (BMR). Steers fed the two different diets were compared to determine differences in the areas of growth/animal performance, ruminal fermentation (digestion), and economic returns. The study included 24 beef steers randomly assigned to one of two treatment groups. Treatment groups were a total mixed feed ration that included …


A Study Of The Variability Versus The Assumed Constancy Of Manning's N, Tyler G. Allen Aug 2014

A Study Of The Variability Versus The Assumed Constancy Of Manning's N, Tyler G. Allen

All Graduate Theses and Dissertations, Spring 1920 to Summer 2023

Culverts have traditionally been designed to a minimal size to pass a specific design flood. The traditional culvert designs may result in a localized increase in velocity which can result in a blockage of animal or fish movement across a barrier effectively changing the ecosystem surrounding a number of affected species. While hydraulic loss coefficients are relatively well defined for such traditional culverts, the National Cooperative Highway Research Program (NCHRP) identified a need for further study of these coefficients for culverts more conducive to fish and animal passage.

A research team headed by Dr. Blake Tullis of Utah State University …


Producing An Ovine Model Of Cystic Fibrosis, Kira Perry Morgado May 2014

Producing An Ovine Model Of Cystic Fibrosis, Kira Perry Morgado

All Graduate Theses and Dissertations, Spring 1920 to Summer 2023

Cystic Fibrosis (CF) is an autosomal recessive disease that significantly affects quality of life and lifespan. There are currently no effective animal models of CF that mimic the human disease state. This prevents the development of pharmaceutical treatments for patients. Sheep have been considered for a useful animal model because of their size, life expectancy, and similarities in their anatomy and physiology. In order to generate a sheep transgenic model to study CF we have produced two Cystic Fibrosis Transmembrane Conductance Regulator (CFTR) gene targeting DNA vectors containing large regions of homology to the CFTR gene in sheep. One of …