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Upregulation Of Somatostatin Receptor 2 In Neuroendocrine Tumors Using Histone Deacetylase Inhibitors, Rachael Elizabeth Guenter Jan 2021

Upregulation Of Somatostatin Receptor 2 In Neuroendocrine Tumors Using Histone Deacetylase Inhibitors, Rachael Elizabeth Guenter

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Neuroendocrine cancer is complex disease of the diffuse neuroendocrine system. Neuroendocrine tumors (NETs) can arise throughout the body, including the lungs and pancreas. These tumors are phenotypically and genetically heterogeneous, making accurate diagnoses difficult with current imaging standards. New diagnostic options, coupled with a better understanding of neuroendocrine cancer etiology, is urgent and necessary to provide patients with better futures. Many NETs overexpress somatostatin receptor 2 (SSTR2) on their cellular surfaces, making patients eligible for [68Ga]-DOTATATE PET/CT imaging and SSTR2-based therapies. However, patients that lack sufficient SSTR2 overexpression cannot benefit from SSTR2-targeted imaging or therapeutic options. We found that histone …

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Evidence For A Bioelectrical Marker Of Insulin Resistance In Premenopausal Women: Membrane Capacitance, Valene E Garr Barry Jan 2021

Evidence For A Bioelectrical Marker Of Insulin Resistance In Premenopausal Women: Membrane Capacitance, Valene E Garr Barry

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Insulin resistance (IR) is associated with poor metabolic and reproductive outcomes among premenopausal women. Early identification of women with IR might mitigate these outcomes. However, clinically suitable methods to identify women with IR are unavailable due to high cost, high patient burden, or limited reliability. The objective was to examine a bioimpedance-based approach to identifying women with IR using membrane capacitance (CM). CM is a measure of cell membrane health and function, which is independently associated with IR and may be a suitable predictor. We validated the association of CM with IR and established the clinical utility of CM as …

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Predictors Of Subjective And Objective Everyday Functioning In Middle-Aged And Older Adults With Hiv, Alexandra Elaine Jacob Jan 2021

Predictors Of Subjective And Objective Everyday Functioning In Middle-Aged And Older Adults With Hiv, Alexandra Elaine Jacob

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People with HIV (PWH) are at an increased risk for everyday functionalimpairment, especially as they age. The purpose of this study was: (1) to identify factors associated with subjective and objective instrumental activities of daily living (IADL) difficulty in PWH and (2) to identify factors associated with awareness of functional capacity. This cross-sectional study included 261 PWH. Participants completed a comprehensive neurobehavioral assessment, including self-report and performance-based measures of everyday functioning. Hierarchical multiple regressions were performed to identify health, psychological, and cognitive factors that contribute to subjective and objective evaluation of everyday functioning. We also examined factors that predicted a …

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Gait Adaptability With Healthy Aging And Parkinson’S Disease, Daniel Kuhman Jan 2021

Gait Adaptability With Healthy Aging And Parkinson’S Disease, Daniel Kuhman

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Human locomotion often occurs through environments with complex sets of external demands (e.g., obstacles, uneven surfaces, altered terrain, etc.). Fortunately, humans have developed locomotor systems capable of rapidly adapting gait patterns to navigate these environments. Advanced age and neurological disorders such as Parkinson’s disease (PD) are associated with physiological changes that add to the complexity of locomotion – these individuals must not only adapt to changing environmental demands, but also to changes in internal function (e.g., reduced muscle strength, dysfunctional sensorimotor integration). While there is a growing body of literature indicating that healthy older adults maintain adaptability, less is known …

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Chemical, Physical, And Antibacterial Properties Of Contemporary Pulp Capping Materials, Yu-Yin Lin Jan 2021

Chemical, Physical, And Antibacterial Properties Of Contemporary Pulp Capping Materials, Yu-Yin Lin

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The purpose of this project was to compare the chemical, physical, and antibacterial properties of right contemporary direct pulp capping materials. The material categories included in this study were calcium hydroxide (Dycal, Lime-Lite and Ultra-Blend plus), calcium silicate (MTA Angelus, Biodentine, TheraCal LC), calcium aluminate (Ceramir Protect LC), and resin ionomer (Bio-Cap). Calcium release and pH changes were measured via a calcium ion-selective electrode (Vernier Company) and pH sensor (Vernier Company) respectively, after specimens were immersed in 36.8oC deionized water for 1, 7, 28 and 90 days. Water solubility was calculated with weight loss of the specimens from 0 to …

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A Randomized Controlled Trial To Compare The Histomorphometric And Clinical Outcomes Of Soft Tissue Augmentation At The Time Of Lateral Ridge Augmentation Procedures, Kenneth Liu Jan 2021

A Randomized Controlled Trial To Compare The Histomorphometric And Clinical Outcomes Of Soft Tissue Augmentation At The Time Of Lateral Ridge Augmentation Procedures, Kenneth Liu

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Guided bone regeneration (GBR) can be used to augment deficient alveolar ridges in preparation for dental implant placement. Mucogingival deformities can result from the periosteal releasing incision during GBR. This can be addressed by additional soft tissue augmentation procedures to increase the width of keratinized tissue and vertical soft tissue thickness, both of which have demonstrated clinical benefits around implants. The drawbacks of soft tissue augmentation following ridge augmentation include an additional procedure, increased patient morbidity, and less patient acceptance of treatment. In general, soft tissue augmentation can be performed at various time points throughout treatment, but literature on soft …

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Characterization Of The Metabolic And Cognitive Features Of A Novel Alzheimer’S Disease Rat Model Along With Investigation Of Its Gut Microbiota Change Over Time, Akash Nagarajan Jan 2021

Characterization Of The Metabolic And Cognitive Features Of A Novel Alzheimer’S Disease Rat Model Along With Investigation Of Its Gut Microbiota Change Over Time, Akash Nagarajan

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Alzheimer’s disease (AD) is currently the fifth highest cause of death in the United States and affects primarily individuals of very old age (>80 yrs.). Aging is known to be the biggest risk factor of AD. Recent studies have shown that AD patients have an altered gut microbiota composition. To investigate whether the Alzheimer’s disease pathology in the brain could drive gut microbiota changes during the adult and late life stage of the rat, we performed 16S ribosomal RNA sequencing on the fecal samples of the animals at 14 months and 20 months of age. We found a distinctive …

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Evaluation Of Antimicrobial Effect Of Licorice Extrcat Agiasnt Oral Microorganisms, Roshanak Rastegar Jan 2021

Evaluation Of Antimicrobial Effect Of Licorice Extrcat Agiasnt Oral Microorganisms, Roshanak Rastegar

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Introduction: The causative factors of dental caries have been studied for many years, however, preventing the formation of dental caries remains an elusive task. Microorganisms have been the focal point of numerous studies as a prime cariogenic factor. Streptococcus mutans and Candida albicans have been frequently co-isolated from dental biofilm in patients with early childhood caries (ECC) and studies have demonstrated the synergistic effects of these two microorganisms in promoting tooth demineralization. Acid and glucan production, which are two virulence factors produced by S. mutans that mediate biofilm formation and tooth decay, have been shown to be promoted during co-colonization …

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The Psychological, Social, And Bioinformatic Considerations For The Return Of Continental Genetic Ancestry Estimates And Other Secondary Sequencing Results, Jaimie Leighan Richards Jan 2021

The Psychological, Social, And Bioinformatic Considerations For The Return Of Continental Genetic Ancestry Estimates And Other Secondary Sequencing Results, Jaimie Leighan Richards

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With recent advances in sequencing technologies, large scale genome wide sequencing has advanced our understanding of disease risk and etiology. These tests, however, often provide secondary data beyond the scope of the original sequencing objectives, and our understanding of how and if participants want to receive these secondary results is important as clinical and research-based sequencing becomes commonplace. To address this, we completed a systematic review of quantitative research that measures attitudes and preferences on the return of genomic sequencing results. Based on that review, we studied the return of genetic ancestry since these results, popularized in direct-to-consumer sequencing companies …

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Assesing The Degree Of Intereron Gamma Induced Stat1 Activation On Peripheral Lymphocytes In Patietns With Rheumatoid Arthritis, Vishal Sharma Jan 2021

Assesing The Degree Of Intereron Gamma Induced Stat1 Activation On Peripheral Lymphocytes In Patietns With Rheumatoid Arthritis, Vishal Sharma

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Rheumatoid Arthritis (RA) is a systemic autoimmune disease with debilitating side effects, from joint swelling to bone erosion and bone deformation. Geographically, RA affect 0.5 – 1% of the worldwide populations, affecting women more than men. Studies have shown that CD4 T cells infiltrate RA synovium and are key to the pathogenesis of RA. Furthermore, drugs targeting co-stimulatory T cell molecules such as abatacept can be beneficial in controlling RA disease activity.Interferon gamma (IFN) is a pleotropic cytokine that contributes to inflammation by aiding in CD4 T cell differentiation into Th1 subtype, enhancing MHC class II presentation, supplementing lymphocyte trafficking, …

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Mechanism Of Stat3 Mediated Drug Persistence In Chronic Myeloid Leukemia Stem Cells, Sweta B. Patel Jan 2021

Mechanism Of Stat3 Mediated Drug Persistence In Chronic Myeloid Leukemia Stem Cells, Sweta B. Patel

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Drug persistence is one of the major impediments for cancer therapeutics. There are two known evolutionary models for tumor drug persistence. First, a pre-existing sub-population is inherently resistant to treatment; and second, a sub-population acquires resistance by drug-induced molecular reprograming. One ideal model to study the mechanism of drug persistence is chronic myeloid leukemia (CML), a hematopoietic stem cell (HSC) disorder. HSCs acquire a single translocation between chromosome 9 and 22, forming BCR-ABL, a constitutively active tyrosine kinase. Tyrosine kinase inhibitors (TKI), the standard regimen, have been able to efficaciously control CML and yet many patients relapse upon treatment discontinuation …

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An Investigation Into The Effects Of Diet On Pain And Pain Disparities, Larissa Jane Strath Jan 2021

An Investigation Into The Effects Of Diet On Pain And Pain Disparities, Larissa Jane Strath

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Chronic pain is one of the most common and disabling disorders in Westernsociety. Recently, it has been suggested that dietary quality may play a key role in the development and maintenance of pain. Additionally, diet differs between demographic groups, as does physiological differences in response to metabolites. We sought to explore 1) the central way in which diet influences pain sensitivity and 2) if dietary patterns affected various demographic groups differently. We first employed a rat model to observe diet-related changes in the dorsal horn of the spinal cord. In the absence and presence of an injury, rats fed a …

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Mothering Ourselves To Wholeness: Employing Black Feminist Criticism & Critical Narrative Methods To Trace Black Maternal Archetypes & Restory The Praxas Of Socio-Politically Engaged Black Mothers In Rural, Suburban, & Urban Contexts, Martez D. Files Jan 2021

Mothering Ourselves To Wholeness: Employing Black Feminist Criticism & Critical Narrative Methods To Trace Black Maternal Archetypes & Restory The Praxas Of Socio-Politically Engaged Black Mothers In Rural, Suburban, & Urban Contexts, Martez D. Files

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Mothering Ourselves to Wholeness: Employing Black Feminist Criticism & Critical Narrative Methods to Trace Black Maternal Archetypes & Restory the Praxes of Socio-Politically Engaged Black Mothers,” is a project that seeks to uncover the myriad ways Black mothers in diverse geographic spaces in Alabama and in select works of Black literature have forged communal wholeness, protected the most vulnerable, and healed harm outside and within communities. Black Mothering Praxis constellates the communal practices that counter exploitation, center care, accountability, and foster wholeness in a world that breaks and fragments Black bodies and beings. The research begins with identifying the various …

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Characterizing The Role Of Necroptosis Of Airway Epithelial Cells In The Immune Response To Respiratory Pathogens, Ashleigh Nichole Riegler Jan 2021

Characterizing The Role Of Necroptosis Of Airway Epithelial Cells In The Immune Response To Respiratory Pathogens, Ashleigh Nichole Riegler

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Necroptosis, a programmed form of lytic cell death, is initiated by various viral and bacterial pathogens through irreparable ion dysregulation and energy depletion. This cellular damage results in the activation of the cellular kinases RIPK1 and RIPK3, consecutively, and the activation and membrane targeting of MLKL, the latter responsible for lysis. Here we have demonstrated that necroptosis of airway epithelial cells is key in the development of the adaptive immune response to asymptomatic colonization by Streptococcus pneumoniae (Spn). Briefly, necroptotic deficient animals or wildtype animals colonized with Spn lacking the necroptosis-triggering pneumolysin toxin, failed to recruit CD11c+ leukocytes to the …

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The Cellular Role Of Tyrosyl-Dna Phosphodiesterase 1 N-Terminal Domain In Topoisomerase 2-Dna Covalent Complex Repair In Yeast, Isaac Andres Segura Jan 2021

The Cellular Role Of Tyrosyl-Dna Phosphodiesterase 1 N-Terminal Domain In Topoisomerase 2-Dna Covalent Complex Repair In Yeast, Isaac Andres Segura

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Tyrosyl-DNA phosphodiesterase 1 (Tdp1) removes adducts from DNA-ends, including damaged nucleotides and protein-DNA crosslinks such as DNA topoisomerases (Topo1 and Topo2) and Tdp1 itself. The N-terminal domain (NTD) of Tdp1 has been understudied, structurally unresolved, and seemingly dispensable for in vitro catalytic activity. However, our lab made the novel observation that the NTD is critical for Tdp1 cellular activity in removing Topo1-DNA covalent complexes (Topo1cc). Removal of the first 80 residues (yeast Tdp1 NTD) results in the loss of the toxic phenotype induced by full-length Tdp1 catalytic mutants. This suggests that in cells the NTD has a critical function in …

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The Relationships Fathers Have With Their Co-Residential Adult Children With Developmental Disabilities: A Qualitative Exploration Of Fatherhood And Masculinity, Kirsten Leigh Ostergren Clark Jan 2021

The Relationships Fathers Have With Their Co-Residential Adult Children With Developmental Disabilities: A Qualitative Exploration Of Fatherhood And Masculinity, Kirsten Leigh Ostergren Clark

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This dissertation explored the relationships between fathers and their co-residential adult children who have been diagnosed with an intellectual and developmental disability (IDD). This research addressed 1) the ways fathers understand their involvement in the lives of their adult child with developmental disabilities, especially as it relates to their masculinity; 2) how fathers perceive that their experiences fathering their child have impacted their health and health behaviors, including how masculinity plays a part; and 3) what supports fathers stated they have utilized and recommend, along with what challenges and constraints fathers feel they have faced. My analysis of in-depth interviews …

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Disrupting The Perioperative Opioid Gateway: Identification Of Risk Factors For New Persistent Post-Surgical Opioid Use, Gia Marie Pittet Jan 2021

Disrupting The Perioperative Opioid Gateway: Identification Of Risk Factors For New Persistent Post-Surgical Opioid Use, Gia Marie Pittet

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A large portion of the American Opioid Crisis is due to opioid naïve patients who become new persistent post-surgical opioid users, although the risk factors for the development of this addiction are not well studied. The objective of this study was to analyze multiple layers of pre-operative and procedural risk factors using an ecological perspective theoretical framework in adult patients undergoing invasive surgery. We performed a retrospective analysis of 13,970 opioid naïve adults in a mixed surgical cohort with data available at the University of California Los Angeles that was merged with narcotics data for the State of California (IRB#19-000625). …

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Beautiful Hunt, Dena Leonard Pruett Jan 2021

Beautiful Hunt, Dena Leonard Pruett

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Beautiful Hunt explores the moment when you realize what is now never will be again no matter how hard you might try to go back. This work also explores developing selfhood – the tension between who we are, who we want to become, how we see ourselves, and how others see us. How is our story told, and who gets to tell it? In January 1998, Alice Landry arrives in the small town of Sans Souci, the boot of the boot of Louisiana. Her father, Sans Souci born and raised, moved away when he married Alice’s mom, a New York …

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Inflammation, Executive Function, And Adiposity In Children With Or At Risk For Obesity, Kathryn L. Prendergast Jan 2021

Inflammation, Executive Function, And Adiposity In Children With Or At Risk For Obesity, Kathryn L. Prendergast

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Obesity is associated with executive function (EF) deficits across the lifespan. Higher body mass index (BMI), greater severity of obesity, and poorer adherence and weight outcomes in obesity treatment have all been associated with EF deficits. Adult literature has begun to emphasize neuroinflammation in obesity as a possible pathway to later cognitive impairment. However, the pediatric obesity literature has yet to even establish associations between peripheral inflammation and EF. Thus, the present study aimed to examine associations and variability in inflammatory biomarkers, EF, and adiposity in children with or at risk for obesity. Additionally, inflammation was examined as a mechanism …

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Biomarker And Target Discovery In Cancer, Alyncia Dominique Robinson Jan 2021

Biomarker And Target Discovery In Cancer, Alyncia Dominique Robinson

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Cancer is a complex disease characterized by uncontrolled growth of transformed cells that can arise in many tissue types throughout the body (e.g., breast, lung, prostate, pancreas, lymph nodes) and is a major cause of death worldwide. Cancer progression resulting in aggressive or metastatic disease accounts for one of the leading causes of death worldwide, second only to heart disease in the US. Incidentally, cancer-related mortality has been on a steady decline, dropping 25% over the last 25 years [1]. This could be attributed to improved and earlier diagnoses and better treatment options being developed over the past few decades. …

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Keller-Segel Type Chemotaxis Model: Asymptotic Behavior Of The Small Data Solution, Jean D. Rugamba Jan 2021

Keller-Segel Type Chemotaxis Model: Asymptotic Behavior Of The Small Data Solution, Jean D. Rugamba

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This dissertation’s work is on asymptotic behavior of a Keller- Segel type chemotaxismodel with logarithmic sensitivity and logistic growth. The logarithmic singularity in the system is removed via the inverse Hopf-Cole transformation. Then, for the transformed system, we study the Green’s function of the corresponding linear system, linearized around a constant equilibrium solution, and the results give us a detailed point-wise description of the Greens function, which, itself, is significant in linear theory. Next, with the results on the Green’s function, we study small data solution to the nonlinear system by making use of Duhamel’s principle. This provides a descriptive …

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Applications Of Longitudinal Machine Learning Methods In Multi-Study Alzheimer's Disease Datasets, Charles F. Murchison Jan 2021

Applications Of Longitudinal Machine Learning Methods In Multi-Study Alzheimer's Disease Datasets, Charles F. Murchison

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Advances in statistical learning models for prediction have led to broader application across a variety of disciplines, granting generalizations and adaptations that were previ-ously intractable even with advanced computational techniques. Among these is the al-lowance of correlated data with inherent paneled structure such as longitudinal or clus-tered data; adjustments which have already begun to be applied to a variety of supervised and unsupervised machine learning methods which had previously focused on cross-sec-tional data. These modifications have seen rudimentary testing in a number of applied disciplines where correlated data is commonly observed, including medical and clinical research. One field in particular …

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Neonatal Murine Cytomegalovirus Infection Disrupts Synapse Remodeling During Development, Jerome Moulden Jan 2021

Neonatal Murine Cytomegalovirus Infection Disrupts Synapse Remodeling During Development, Jerome Moulden

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Human cytomegalovirus (HCMV) is a complex double stranded DNA betaherpesvirus. Its linear DNA in enclosed in an icosahedral capsid, and has a genome size of about 230kb and encodes about 170 genes. Primary infection with HCMV lead to a lifelong persistent infection. HCMV can also be transmitted across the placenta and infect the developing fetus leading to infection of the newborn infant, an infection which is commonly described as congenital HCMV infection. In the United States, the prevalence of congenital HCMV infection is between 0.2-1.2%. Approximately 5-15% of these newborn infants will develop long-term neurological damage resulting, motor disorder, cognition …

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Multidrug-Resistance, Antibiotic-Associated Acute Kidney Injury, And Poor Disease Prognosis In Community-Acquired Bacterial Pneumonia, Adeniyi J. Idigo Jan 2021

Multidrug-Resistance, Antibiotic-Associated Acute Kidney Injury, And Poor Disease Prognosis In Community-Acquired Bacterial Pneumonia, Adeniyi J. Idigo

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In this dissertation research, I examined the challenges of treating patients with bacterial community-acquired pneumonia (CAP) with the purpose of identifying risk factors linked with multidrug-resistant (MDR) Pseudomonas, treatment toxicity, and poor disease prognosis. I used a retrospective cohort study design to explore a clinical cohort of patients admitted to the University of Alabama at Birmingham hospital network who had bacterial pneumonia diagnosis assessed to be from community transmission between January 2013-December 2019. Electronic medical records were accessed for socio-demographic and clinical information. First, I examined the local prevalence/incidence of Pseudomonas CAP and MDR Pseudomonas CAP, and the relationship between …

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Studies On Nontypeable Haemophilus Influenzae Biofilm Persistence & Redox Homeostasis In Chronic Bacterial Diseases, Benjamin C. Hunt Jan 2021

Studies On Nontypeable Haemophilus Influenzae Biofilm Persistence & Redox Homeostasis In Chronic Bacterial Diseases, Benjamin C. Hunt

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Bacterial biofilms, or surface-adherent bacterial communities surrounded by a self-produced extracellular polymeric matrix, are ubiquitous. They are found throughout Earth’s ecosystems, in the soil and waterways, and more pressingly for the medical community, they are found within humans. Bacterial biofilms are associated with a multitude of diseases and their involvement significantly complicates treatment given that bacteria growing within a biofilm are extremely more resistant to antibiotics and immune effectors. Thus, the need to better understand biofilm biology and find ways to disrupt and/or sensitize biofilms to medical treatment is significant. The goal of the research presented herein was to investigate …

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Shades Of Black: Black Collegiate Women And The Impact Of Colorism In Higher Education, Charletta Nickole Wiggins Jan 2021

Shades Of Black: Black Collegiate Women And The Impact Of Colorism In Higher Education, Charletta Nickole Wiggins

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Colorism perpetuates the same variables that drive the principles of racism and has led to disparate treatment, lower self-esteem, and negative perceptions within communities of color for decades. Since Black women are considered second class citizens, behind both men and White women, it is vital to acknowledge that their experiences with racism, compounded by colorism, are most salient. The purpose of this qualitative research study is three-fold: (1) to explore colorism as a phenomenon while also investigating its impact on the higher education attainment of Black collegiate women, (2) to give these women a voice regarding their personal experiences with …

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Low Illumination Video Enhancement Based On Machine Learning, Mohsine Taarji Jan 2021

Low Illumination Video Enhancement Based On Machine Learning, Mohsine Taarji

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ow-brightness and image noise are common problems in computer vision that prohibit useful information extraction from video sequences. This problem is caused by insufficient illumination, low-quality cameras, external disturbances, and other factors. Dark image enhancement requires improvement of intensity and saturation; the missing data could be replaced by matching image regions using image feature detector-descriptor pairs. We proposed new metrics for evaluating image descriptors with regard to their uniqueness. Also, we developed new image enhancement techniques based on HSV color space. The idea behind the first contribution of our dissertation is to find the best descriptor that match pixels from …

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Functions Of Drosophila Hp1 Proteins In Transcriptional Regulation, John Schoelz Jan 2021

Functions Of Drosophila Hp1 Proteins In Transcriptional Regulation, John Schoelz

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The Heterochromatin Protein 1 (HP1) family are a group of non-histone chromosomal proteins with functions in many essential DNA processes. The HP1 family is highly conserved, and many eukaryotic genomes contain multiple HP1 genes. Individual paralogs specialize in specific functions, although they do have overlapping roles in some processes. In Drosophila, there are three HP1 paralogs expressed in somatic cells: HP1a, HP1B and HP1C. All three of these proteins have previously been implicated in both the positive and negative regulation of transcription. Furthermore, the three proteins share binding sites and colocalize broadly throughout the Drosophila genome. Here, we investigate individual …

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Effeccts Of Hiv-1 Tat On Tspo, A Biomarker Of Neuroinflammation, Nguyen Thuy Nhu Nguyen Jan 2021

Effeccts Of Hiv-1 Tat On Tspo, A Biomarker Of Neuroinflammation, Nguyen Thuy Nhu Nguyen

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HIV-associated neurocognitive disorders (HAND) produces serious neurological dysfunction for > 50% of people living with HIV (PLWH). As antiretroviral therapy (ART) has transformed HIV into a chronic disease, and since most ART does not effectively cross the blood brain barrier, HAND is predicted to further increase in prevalence in PLWH. The HIV-Trans-Activator of Transcription (Tat) is known to persist in the central nervous system (CNS) of chronically infected HIV+ individuals. In several preclinical studies, HIV-Tat has been shown to be neurotoxic and important for HIV pathogenesis. Translocator protein (TSPO), an 18 kDa mitochondrial protein, has been shown to be increased via …

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Characterization Of Rna Polymerase I Trigger Loop Mutations, Collin Ainslie Jan 2021

Characterization Of Rna Polymerase I Trigger Loop Mutations, Collin Ainslie

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RNA polymerases are primarily multi-subunit enzymes that synthesize RNAs from template DNA strands. RNA polymerase I (Pol I) is the eukaryotic RNA polymerase that synthesizes the majority of ribosomal RNA (rRNA) for ribosome production. These include the 5.8S, 28S, and 18S rRNAs which are synthesized from a polycistronic gene in the nucleolus. The rRNAs synthesized by Pol I, the 5S rRNA, & ribosomal proteins come together to synthesize ribosomes through ribosome biogenesis. Dysregulation of Pol I activity has been established to contribute to dysregulation of ribosome biogenesis and disease state development. These conditions include but are not limited to Cincinnati …

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