Open Access. Powered by Scholars. Published by Universities.®

Digital Commons Network™

Open Access. Powered by Scholars. Published by Universities.®

All ETDs from UAB

Discipline
Keyword
Publication Year

Articles 2071 - 2100 of 3685

Full-Text Articles in Entire DC Network

Transcriptional Regulation Of Cd40 And Class Ii Mhc Molecules In Macrophages And Microglia By Statins, Sun Jung Lee Jan 2008

Transcriptional Regulation Of Cd40 And Class Ii Mhc Molecules In Macrophages And Microglia By Statins, Sun Jung Lee

All ETDs from UAB

Microglia/macrophages are the main intrinsic immune effector cells and the first cell types that respond to a variety of CNS injures. They have important functions including secretion of cytokines/chemokines and antigen presentation, thereby regulating immune responses. Interferon-γ (IFN-γ) is a cytokine involved in many aspects of the immune response, and activates microglia/macrophages to express cell surface antigens such as class II MHC, and co-stimulatory molecules such as CD40. CD40 and class II MHC molecules play a critical role in immune reactivity such as antigen presentation and subsequent T cell activation. However, aberrant CD40 and class II MHC expression have been …

Go to article

Modulation Of Transforming Growth Factor (Tgf)-Ss1 And Its Implications In Breast Cancer Metastasis, Lakisha Dionne Moore Jan 2008

Modulation Of Transforming Growth Factor (Tgf)-Ss1 And Its Implications In Breast Cancer Metastasis, Lakisha Dionne Moore

All ETDs from UAB

Overexpresssion of transforming growth factor (TGF)-β has been implicated in promoting immune suppression, tumor angiogenesis, tumor cell migration, and invasion in many cancers including carcinoma of the breast. Thus, targeted downregulation of TGF-β1 expression in breast cancer in situ and determination of its implications potentially could provide new treatment approaches for disease management. siRNA constructs targeting TGF-β1 were validated and used to develop clonal derivatives of the MDA-MB-435 metastatic breast cancer cell line. Inhibition of TGF-β1 expression in MDA-MB-435 cells showed decrease in migration and invasion in vitro with an increase in proliferation. In vivo analysis indicated a 90% decrease …

Go to article

Relationships Among Anger, Patterns Of Anger Expression And Blood Pressure, Glucose, And Cortisol In Overweight School-Aged Children, Kimberly Nichols Jan 2008

Relationships Among Anger, Patterns Of Anger Expression And Blood Pressure, Glucose, And Cortisol In Overweight School-Aged Children, Kimberly Nichols

All ETDs from UAB

Overweight and obesity in school-aged children have become a major health issue. With overweight and obesity, children have increased risk of developing elevated blood pressure readings, glucose levels, and cortisol. Trait anger and patterns of anger expression have been shown to contribute to the elevations of blood pressure, glucose and cortisol in normoweight children and overweight adolescents. However, little research has been done with overweight school-aged children. The purpose of this study was to examine the relationships among trait anger and each of the patterns of anger expression (anger-suppression, anger-out, and anger-reflection/control) and blood pressure, glucose, and cortisol in overweight …

Go to article

Transition Metal Complexes Of Bis(Phosphorus) Donor Ligands Derived From Multifunctional Diols: Synthesis, Isomerization, Cation Binding, And Catalysis., Samuel Britt Owens Jan 2008

Transition Metal Complexes Of Bis(Phosphorus) Donor Ligands Derived From Multifunctional Diols: Synthesis, Isomerization, Cation Binding, And Catalysis., Samuel Britt Owens

All ETDs from UAB

In Chapter 1, the metallacrown ethers cis-[PdCl2{Ph2P(CH2CH2O)3CH2CH2PPh2-P,P’}] and trans-PtCl2{Ph2P(CH2CH2O)3CH2CH2PPh2-P,P’} were studied. These metallacrown ethers are ideal candidates for the study of the kinetics and thermodynamics of cis-trans isomerizations because of their highly flexible backbones. We have carried out these studies using 31P NMR spectroscopy, and the equilibrium constants and thermodynamic and kinetic parameters for these reactions are reported. Chapter 2 of this dissertation explores the cation binding ability of the tartaric acid backbone proposed as the building block for the ligands developed herein for the hydroformylation of styrene. Binding studies and crystallographic analysis confirmed that incorporating the tartaric acid backbone …

Go to article

Investigation Of Lipoteichoic Acid Structure And Function To Establish Its Role In Gram-Positive Bacterial Infections, Ho Seong Seo Jan 2008

Investigation Of Lipoteichoic Acid Structure And Function To Establish Its Role In Gram-Positive Bacterial Infections, Ho Seong Seo

All ETDs from UAB

Lipoteichoic acid (LTA) is an essential bacterial membrane polysaccharide (cell wall component) that is linked to a glycerol backbone with two acyl chains. Since an antibody to LTA has been shown to protect from Gr+ bacterial infections or colonization, and the mutant Gr+ bacteria which produce less amount of LTA have less pathogenic than WT, LTA may be an important role in Gr+ bacterial infection and inflammation. The currently accepted structure of pneumococcal LTA has the pentameric repeating unit bound to the lipid anchor {Glc(β1��3)AATGal(β1��3)Glc(α1��3)-acyl2Gro}. Unlike the lipid anchor of other Gr+ bacterial LTA, this pneumococcal LTA lipid anchor has …

Go to article

An Exploration Of Factors Related To Hypertension Control In African American And Caucasian Municipal Employees, Sunun Sinsuesatkul Jan 2008

An Exploration Of Factors Related To Hypertension Control In African American And Caucasian Municipal Employees, Sunun Sinsuesatkul

All ETDs from UAB

Hypertension is a major contributor to morbidity, mortality, and medical costs in the United States. African Americans (AAs) have the highest prevalence of hypertension in the world, exhibiting at least twice the rate for Caucasians in almost every age and sex group. AAs are also at higher risk for complications from hypertension than Caucasians. While several factors have been proposed as accounting for those differences, there is no consensus on which factors may be responsible; the reasons for disparities in hypertension control in AAs are complex, and need further investigation. This study explored relationships between multiple factors to identify how …

Go to article

Analysis Of The Hedgehog Pathway In Pancreatic Adenocarcinoma, Adam Steg Jan 2008

Analysis Of The Hedgehog Pathway In Pancreatic Adenocarcinoma, Adam Steg

All ETDs from UAB

Pancreatic adenocarcinoma (PAC) is the fourth leading cause of cancer mortality in the United States. Despite the use of highly aggressive treatment regimens (surgery, chemotherapy and radiation), almost all patients succumb to metastatic disease within 6-10 months of diagnosis. The hedgehog (HH) signaling pathway was originally discov-ered to play a critical role in mammalian embryological development. Interestingly, re-cent studies have suggested that aberrant expression of this pathway is involved in the initiation and continued growth of PAC. Small molecules that antagonize the transmem-brane protein Smoothened (Smo), a critical signaling component of the HH pathway, have proven effective in decreasing PAC …

Go to article

Randomized Controlled Trial Of Low Cost Interventions To Reduce Childhood Immunization Dropouts In Pakistan, Hussain Raza Usman Jan 2008

Randomized Controlled Trial Of Low Cost Interventions To Reduce Childhood Immunization Dropouts In Pakistan, Hussain Raza Usman

All ETDs from UAB

Childhood immunization coverage in Pakistan remains sub-optimal despite universal and free of cost availability of vaccines. Structural impediments to progress may include the immunization card that is hard to read and interpret. A randomized controlled trial was conducted to assess the effect of redesigned immunization card and center-based education to mothers on immunization completion at rural immunization centers in Karachi, Pakistan. Other objectives were to identify the predictors of immunization completion and to identify factors associated with delay at first dose of diphtheria-tetanuspertussis (DTP1). Mother-child units were enrolled from six immunization centers at DTP1 and randomized to four study groups: …

Go to article

Effects Of Music Therapy On Preterm Infants In The Neonatal Intensive Care Unit, Ashley Hodges Wood Jan 2008

Effects Of Music Therapy On Preterm Infants In The Neonatal Intensive Care Unit, Ashley Hodges Wood

All ETDs from UAB

The study purpose was to examine the effects of a 15-min live-music therapy intervention on heart rate, oxygen saturation, level of motor activity, behavioral distress, and behavioral state levels in premature infants in the neonatal intensive care unit. The convenience sample included 20 infants born at 26 to 29 weeks’ gestational age who were hospitalized in a large teaching hospital in the southern United States. In a 1-group repeated-measures crossover design, infants were randomly assigned order of music versus no-music conditions. Data were collected on 4 occasions over a 2- to 4-week period beginning when the infants were 1 to …

Go to article

Regulation Of Human Mmp-9 Gene Expression By Transcriptional Coactivators And Interferon Beta, Xueyan Zhao Jan 2008

Regulation Of Human Mmp-9 Gene Expression By Transcriptional Coactivators And Interferon Beta, Xueyan Zhao

All ETDs from UAB

No abstract provided.

Go to article

After Controlling For Other Risk Factors, To What Extent Does The Level Of Parity Account For The Differences In The Probability Of Developing Diabetes Mellitus?, Johnita Dobbs Jan 2008

After Controlling For Other Risk Factors, To What Extent Does The Level Of Parity Account For The Differences In The Probability Of Developing Diabetes Mellitus?, Johnita Dobbs

All ETDs from UAB

No abstract provided.

Go to article

P53-Dependent Neural Stem Cell Death Regulation, Ying Geng Jan 2008

P53-Dependent Neural Stem Cell Death Regulation, Ying Geng

All ETDs from UAB

No abstract provided.

Go to article

Fluorescence Based Optical Sensor For Protein Detection, Kailiang Sun Jan 2008

Fluorescence Based Optical Sensor For Protein Detection, Kailiang Sun

All ETDs from UAB

No abstract provided.

Go to article

Structural And Functional Studies Of Human Bile Acid Coa:Amino Acid N-Acyltransferase (Hbat), Erin Mary Shonsey Jan 2008

Structural And Functional Studies Of Human Bile Acid Coa:Amino Acid N-Acyltransferase (Hbat), Erin Mary Shonsey

All ETDs from UAB

No abstract provided.

Go to article

The Effects Of Catastrophizing And Acceptance On Functional Interference In Persons With Chronic Pain: Laboratory Findings, Subjective Reports, And The Moderating Role Of Acceptance, Elizabeth J. Richardson Jan 2008

The Effects Of Catastrophizing And Acceptance On Functional Interference In Persons With Chronic Pain: Laboratory Findings, Subjective Reports, And The Moderating Role Of Acceptance, Elizabeth J. Richardson

All ETDs from UAB

No abstract provided.

Go to article

Adaptive Procedures To Detect Treatment Effects Under Unexpected Treatment-Covariate Interactions, Nitin K. Nair Jan 2008

Adaptive Procedures To Detect Treatment Effects Under Unexpected Treatment-Covariate Interactions, Nitin K. Nair

All ETDs from UAB

No abstract provided.

Go to article

Dna Methylation Patterns In The Ultraviolet Radiation - Exposed Skin And Tumors: Chemopreventive Role Of Phytochemicals, Vijayalakshmi Nandakumar Jan 2008

Dna Methylation Patterns In The Ultraviolet Radiation - Exposed Skin And Tumors: Chemopreventive Role Of Phytochemicals, Vijayalakshmi Nandakumar

All ETDs from UAB

No abstract provided.

Go to article

Enhancement Of Bonding To Enamel And Dentin Prepared By Er,Cr:Ysgg Laser, Ali Obeidi Jan 2008

Enhancement Of Bonding To Enamel And Dentin Prepared By Er,Cr:Ysgg Laser, Ali Obeidi

All ETDs from UAB

No abstract provided.

Go to article

Modulation Of Lipoprotein Metbolism And Atherosclerosis By The G Protein-Coupled Receptor, G2a, Brian W. Parks Jan 2008

Modulation Of Lipoprotein Metbolism And Atherosclerosis By The G Protein-Coupled Receptor, G2a, Brian W. Parks

All ETDs from UAB

No abstract provided.

Go to article

The Role Of Neighborhood Residency In The Decision To Evacuate, Naya S. Mcmillan Jan 2008

The Role Of Neighborhood Residency In The Decision To Evacuate, Naya S. Mcmillan

All ETDs from UAB

No abstract provided.

Go to article

Biomimetic Self-Assembled Nanomatrix For Drug Eluting Stent Application, Meenakshi Kushwaha Jan 2008

Biomimetic Self-Assembled Nanomatrix For Drug Eluting Stent Application, Meenakshi Kushwaha

All ETDs from UAB

No abstract provided.

Go to article

The Role Of Centaurins In Vesicular Trafficking And Neuronal Differentiation, Jennifer Lynn Larimore Jan 2008

The Role Of Centaurins In Vesicular Trafficking And Neuronal Differentiation, Jennifer Lynn Larimore

All ETDs from UAB

No abstract provided.

Go to article

Human Leukocyte Antigen Supertypes In Relation To Human Immunodeficiency Virus Infection Among Populations Of African Ancestry, Aleksandr Lazaryan Jan 2008

Human Leukocyte Antigen Supertypes In Relation To Human Immunodeficiency Virus Infection Among Populations Of African Ancestry, Aleksandr Lazaryan

All ETDs from UAB

No abstract provided.

Go to article

Progression Through The Cell Cycle Is Regulated By Dynamic Chloride Dependent Changes In Cell Volumes, Christa Whelan Habela Jan 2008

Progression Through The Cell Cycle Is Regulated By Dynamic Chloride Dependent Changes In Cell Volumes, Christa Whelan Habela

All ETDs from UAB

No abstract provided.

Go to article

The Relationship Of Adolescent Cognitive Ability To Adult Physical Health: Socioeconomic Status And Health Behavior As Mediating Variables, Timothy M. Hale Jan 2008

The Relationship Of Adolescent Cognitive Ability To Adult Physical Health: Socioeconomic Status And Health Behavior As Mediating Variables, Timothy M. Hale

All ETDs from UAB

No abstract provided.

Go to article

Regulation Of Tau Functions By Posttranslational Modifications Of Tau And Histone Deacetylase 6, Huiping Ding Jan 2008

Regulation Of Tau Functions By Posttranslational Modifications Of Tau And Histone Deacetylase 6, Huiping Ding

All ETDs from UAB

Alzheimer’s disease (AD), the most common neurodegenerative disease, is pathologically characterized by senile plaques composed of amyloid β peptide and neurofibrillary tangles composed of hyperphosphorylated and aberrantly cleaved microtubule-associated protein tau. Numerous studies have demonstrated the critical importance of tau in AD pathogenesis; however, the mechanisms involved in the regulation of tau functions by posttranslational modifications of tau and by other cellular factors need to be further elucidated. The first part of my study focused on how posttranslational modifications of tau, specifically, site-specific phosphorylation and C-terminal cleavage, regulate its physiological function in associating with cytoskeleton, binding to and stabilizing microtubules …

Go to article

High Field Functional Magnetic Resonance Imaging In The Awake, Behaving Primate: Cortical Networks Involved In Vergence Eye Movements, Matthew K. Ward Jan 2008

High Field Functional Magnetic Resonance Imaging In The Awake, Behaving Primate: Cortical Networks Involved In Vergence Eye Movements, Matthew K. Ward

All ETDs from UAB

Animals with eyes positioned towards the front of the head are capable of making saccadic and smooth pursuit eye movements to fixate an object at a given distance. These eye movements are conjugate (i.e. both eyes move the same amount in the same direction). To fixate objects at different distances, such animals are also capable of making vergence eye movements in which both eyes move the same amount in opposite directions i.e. disconjugately. While purely conjugate or vergence eye movements rarely occur in daily life, it is useful to study these types of eye movements separately due to the relative …

Go to article

A Dual-Action, Armed Replicating Adenovirus For The Treatment Of Bone Metastases Of Breast Cancer, James Joseph Cody Jan 2008

A Dual-Action, Armed Replicating Adenovirus For The Treatment Of Bone Metastases Of Breast Cancer, James Joseph Cody

All ETDs from UAB

Most patients with advanced breast cancer develop osteolytic bone metastases, which have numerous complications. Because current therapies are not curative, new treatments are needed. Conditionally replicating adenoviruses (CRAds) are anti-cancer agents designed to infect and lyse tumor cells. For increased efficacy, CRAds have been armed with therapeutic transgenes. Osteoprotegerin (OPG), an inhibitor of osteoclastic bone resorption, represents a promising candidate with which to arm a CRAd intended to treat osteolytic bone metastases. We hypothesize that a CRAd armed with OPG will inhibit breast cancer bone metastasis and reduce tumor burden in the bone by directly lysing tumor cells and by …

Go to article

Mesenchymal Stem Cell Interaction With Nanostructured Biomaterials For Orthopaedic Applications, William Charles Clem Jan 2008

Mesenchymal Stem Cell Interaction With Nanostructured Biomaterials For Orthopaedic Applications, William Charles Clem

All ETDs from UAB

Orthopaedic implants fail when bone loss around the anchoring region of the prosthesis causes the components to loosen. A revision surgery is needed to replace worn components, and bone grafting is often required to fill the void caused by osteolysis. A solution for the problem of osteolysis may be the improvement of wear resistance at the articulating surfaces by substituting materials with greater hardness. This dissertation describes two strategies for increasing the surface hardness of titanium alloy (Ti-6Al-4V) implants, without increasing surface roughness or compromising osseointegration. The first strategy utilizes microwave plasma to induce titanium nitride formation by nitrogen diffusion. …

Go to article

Thrombospondin Type-1 Repeats And Their Potential Role In Inhibiting Glioblastoma Angiogenesis, Joshua C. Anderson Jan 2008

Thrombospondin Type-1 Repeats And Their Potential Role In Inhibiting Glioblastoma Angiogenesis, Joshua C. Anderson

All ETDs from UAB

Thrombospondin-1 (TSP-1) is a 420 kilodalton homotrimeric protein; it is one of the first identified anti-angiogenic proteins found to be expressed in some normal tissues. Peptides derived from the type-1 repeat (TSR) domains of full length TSP-1 have been shown to have anti-angiogenic activity, and thus anti-tumor activity in some non-glioma tumor models. I hypothesized that peptides derived from the TSRs of TSP-1, such as ABT-510, could inhibit angiogenesis and thus malignant glioma tumor growth in vivo. I found that ABT-510 inhibited angiogenesis of the human brain microvascular endothelial cell (MvEC) in an in vitro tubulomorphogenesis assay. To determine the …

Go to article

First Prev Next Last