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Fiber Optic Sensors For Detection Of Biomarkers, Chun-Wei Wang Jan 2012

Fiber Optic Sensors For Detection Of Biomarkers, Chun-Wei Wang

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A combination tapered fiber-optic biosensor (CTFOB) dip-probe for rapid and cost effective quantification of proteins in serum samples has been developed. This device relies on diode laser excitation and a charged coupled device (CCD) spectrometer, and functions on a technique of sandwich immunoassay. As a proof-of-principle, this technique was applied in a quantitative estimation of interleukin (IL-6) and Carcinoembyonic antigen (CEA) in human sera. The probes detected IL-6 at picomolar levels in serum samples obtained from a patient with lupus, an autoimmune disease, and a patient with lymphoma. The estimated concentration of IL-6 in lupus sample was 5.9 +/- 0.6 …

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Mechanisms Of Lrrk2 Regulation, Philip J. Webber Jan 2012

Mechanisms Of Lrrk2 Regulation, Philip J. Webber

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Non-synonymous mutations in LRRK2 are the most common known cause of familial and sporadic Parkinson's disease (PD). The dominant inheritance of these mutations in familial PD suggests a gain-of-function mechanism. Increased kinase activity observed in the most common PD associated LRRK2 mutation G2019S suggests that kinase activity is central to disease. However, not all mutations associated with disease are reported to alter kinase activity and controversy exists in the literature about the effects of mutations appearing in the GTPase domain on kinase activity. The studies conducted as a part of this work aim to characterize the mechanisms that regulate LRRK2 …

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Siderophore-Mediated Iron Acquisition In Mycobacterium Tuberculosis, Ryan Wells Jan 2012

Siderophore-Mediated Iron Acquisition In Mycobacterium Tuberculosis, Ryan Wells

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Mycobacterium tuberculosis is a dangerous human pathogen that has the capacity to adapt to and survive within the harsh phagosomal environment of macrophages. One obstacle that must be overcome by pathogens is to acquire iron, an essential component and cofactor of proteins required for vital cellular processes. M. tuberculosis meets its iron demands in the face of an array of sequestration strategies of the host by synthesizing and secreting two siderophores called mycobactin and carboxymycobactin. Siderophores are low molecular weight high affinity iron binding compounds that steal iron away from host stores and have been shown to be important for …

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C-C-Motif Chemokine Receptor/Ligand Gene Variants And Their Associations With Hiv-1 Transmission And Pathogenesis, Liangyuan Hu Jan 2012

C-C-Motif Chemokine Receptor/Ligand Gene Variants And Their Associations With Hiv-1 Transmission And Pathogenesis, Liangyuan Hu

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Host factors including genes and their variants are important to HIV-1 acquisition, transmission and disease progression. In particular, chemokine (C-C motif) receptors 2 and 5 genes (CCR2 and CCR5) have multiple variants of interest. We first investigated the impact of CCR2-CCR5 haplotypes on several outcomes among 567 HIV-1 discordant Zambian couples. HHF*2 homozygosity was associated with significantly lower VL in seroconverters (mean beta=-0.58 log10 P=0.027) and the HHD/HHE diplotype was associated with significantly higher VL in the seroconverters (mean beta=0.54, log10 P=0.014) adjusted for age and gender in multivariable model. HHD/HHE was associated with more rapid acquisition of infection by …

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Acoustical Analysis Of Trained And Untrained Singers Onsite Before And After Prolonged Voice Use, Christophe E. Jackson Jan 2012

Acoustical Analysis Of Trained And Untrained Singers Onsite Before And After Prolonged Voice Use, Christophe E. Jackson

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Controlled acoustic environments are important in voice research. Recording environment affects the quality of voice recordings. While sound booths and anechoic chambers are examples of controlled acoustic environments widely used in research, they are both costly and not portable. The long-term goal of this project is to compare the voice usage and efficiency of trained and untrained singers onsite immediately before and after vocal performance. The specific goal of this project is the further of development a Portable Sound Booth (PSB) and standardization of onsite voice recording procedures under controlled conditions. We hypothesized that the simple and controlled acoustic environment …

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Retinoids And Abnormal Alveolar Development, Masheika L. James Jan 2012

Retinoids And Abnormal Alveolar Development, Masheika L. James

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Extremely preterm infants are at high risk for a form of chronic lung disease called bronchopulmonary dysplasia (BPD), which is characterized by impaired alveolar development. Exposure to hyperoxia and deficiency of vitamin A (VA) contribute to the development of BPD in preterm infants. Randomized controlled trials indicate VA supplementation decreases BPD and/or death. However, 25% of preterm infants continue to remain VA deficient despite supplementation, probably due to impairment in VA transport, VA is stored in the liver as retinyl esters which are transported to the lung and irreversibly metabolized into all-trans-retinoic acid (ATRA), the active metabolite. A combination of …

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Wear Of Ceramics And Enamel In A Chewing Simulator, Sridhar Janyavula Jan 2012

Wear Of Ceramics And Enamel In A Chewing Simulator, Sridhar Janyavula

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Dental ceramics are known for their excellent chemical and optical properties. The wear of human enamel and of the restorative material is often a vital and esthetical concern when selecting a restorative material for any given clinical restorative treatment. Objective: The purpose of the study was to evaluate effect of zirconia (polished, glazed, polished then glazed, adjusted, glazed and adjusted, adjusted and polished and aged zirconia) against human enamel antagonist. A comparison was made between different zirconia, veneering porcelain (Ceramco 3) and natural enamel. Additionally, the surface roughness (Ra) of the ceramic surface was measured before and after wear testing …

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The Role Of Endoplasmic Reticulum Stress Response In Glioma Cell Death, Guyla G. Johnson Jan 2012

The Role Of Endoplasmic Reticulum Stress Response In Glioma Cell Death, Guyla G. Johnson

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Malignant gliomas, including glioblastomas, are the main primary adult brain tumor. Even with current therapies, the median survival time for patients diagnosed with glioblastomas is only about 12 months. Therefore, it is imperative to identify pathways that can induce glioma cell death. This dissertation provides evidence defining how Endoplasmic Reticulum Stress Response (ERSR) induction promotes cell death selectively in malignant glioma cells (MGCs). I present data showing a correlation between ER Ca2+ storage abnormalities, ER ribosome-translocon expression and activity, ERSR intensity and cell death in MGCs. These data show ERSR induction with thapsigargin (THAP) results in a larger loss of …

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The Role Of C-Reactive Protein In Arthritic Disease, Nicholas Ryan Jones Jan 2012

The Role Of C-Reactive Protein In Arthritic Disease, Nicholas Ryan Jones

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C-reactive protein (CRP) is an acute phase protein that is commonly used to evaluate systemic inflammation level. Blood CRP level also correlates very well with rheumatoid arthritis (RA) disease severity. However, CRP has many biological actions that lead one to suspect that it may be playing a role in the development or pathology of the disease. We have directly addressed whether this is the case by the use of novel mouse models (CRP deficiency or transgenic overexpression). We have shown that CRP positively affects collagen-induced arthritis development and progression. In order to thoroughly address the question, we have also reported …

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Mycobacterial Iron Acquisition Systems, Christopher M. Jones Jan 2012

Mycobacterial Iron Acquisition Systems, Christopher M. Jones

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Iron is an essential nutrient for the vast majority of organisms; yet, the availability of iron is limited to microorganisms due to the insolubility of ferric hydroxides and to pathogens by iron withholding strategies of their hosts. Many bacteria produce small, high-affinity iron chelators called siderophores to scavenge iron from the environment. In addition, many bacterial pathogens have evolved mechanisms to steal host iron contained in heme, hemoglobin, or transferrin. Mycobacteria are unique genera of bacteria represented by the notorious pathogens Mycobacterium tuberculosis and Mycobacterium leprae, the causative agents of tuberculosis (TB) and leprosy, respectively. Tuberculosis remains a global health …

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Differential Expression Of Proteins In Keratoconus: Potential Role Of Human Antigen R (Hur) In Regulation Of Ss-Actin Gene, Roy Joseph Jan 2012

Differential Expression Of Proteins In Keratoconus: Potential Role Of Human Antigen R (Hur) In Regulation Of Ss-Actin Gene, Roy Joseph

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DIFFERENTIAL EXPRESSION OF PROTEINS IN KERATOCONUS: POTENTIAL ROLE OF HUMAN ANTIGEN R (HuR) IN REGULATION OF ß-ACTIN ROY JOSEPH VISION SCIENCES ABSTRACT Keratoconus (KC) is a condition of unknown cause in which the cornea assumes a conical shape as a result of non-inflammatory thinning of the corneal stroma. The disease progresses at a variable speed with corneal thinning inducing irregular astigmatism, myopia, and corneal protrusion. Contact lenses, and ultimately keratoplasty, are often required to restore vision. Despite intensive investigations into the pathogenesis of KC, the exact cause of the disease is presently poorly understood. Keratoconus apparently arises due to number …

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Application Of The Social Cognitive Theory To A Web-Based Physical Activity Intervention For Overweight African American Female College Students, Rodney Joseph Jan 2012

Application Of The Social Cognitive Theory To A Web-Based Physical Activity Intervention For Overweight African American Female College Students, Rodney Joseph

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Background.African American women report low levels of physical activity and share a disproportionate burden of many health conditions associated with being insufficiently active, indicating the need for innovative approaches to promote physical activity in this population. The purpose of the current study was to evaluate changes in physical activity and associated Social Cognitive Theory constructs of outcome expectations, enjoyment, self-regulation, and social support following the completion of a six month, culturally-adapted, Social Cognitive Theory-based website-delivered weight loss and physical activity intervention for young African-American women. Methods.A secondary data analysis was performed on African-American female college students (N=34) enrolled in a …

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A Study Of The Genetic Mechanisms Used To Regulate The Third Complementarity Determining Region Of The Immunoglobulin H Chain, Mohamed Khass Jan 2012

A Study Of The Genetic Mechanisms Used To Regulate The Third Complementarity Determining Region Of The Immunoglobulin H Chain, Mohamed Khass

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Developing B cells exhibit sequential changes in the representation of immunoglobulin (Ig) heavy (H) chain sequences with excess hydrophobic or charged amino acids in complementarity determining region 3 (CDR-H3). To begin to elucidate the mechanisms by which this process occurs, we used Bromodeoxy Uridine (BrdU) incorporation and Annexin V binding to quantify B cell turnover and cell cycle progression in developing B cell subsets in the bone marrow, spleen and peritoneal cavity of wild-type BALB/c mice. To magnify the effects of hydrophobicity and charge, we included in this analysis mice limited to the use of an IgH allele with a …

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Is P53 A Target Of Hpv-18 E6 In The Viral Life Cycle?, Eun-Young Kho Jan 2012

Is P53 A Target Of Hpv-18 E6 In The Viral Life Cycle?, Eun-Young Kho

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The large family of human papillomaviruses (HPVs) infects the cutaneous or mucosal epithelia causing benign hyper proliferative diseases. Infections by the high-risk (HR) HPV genotypes in the anogenital tracts can progress to high grade lesions and cancers in men and women. Because the viral productive program requires squamous differentiation of epithelia, HPV encodes oncoproteins that recondition the differentiated cells that have withdrawn from the cell cycle to support viral DNA amplification. The HR HPV E6 and E7 oncogenes are selectively expressed in cervical carcinomas and are necessary to maintain the malignant state. In vitro, constitutive expression of the HR HPV …

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Regulation Of Cell Death By Autophagy In Glial Neoplasms, Latika R. Kohli Jan 2012

Regulation Of Cell Death By Autophagy In Glial Neoplasms, Latika R. Kohli

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Malignant peripheral nerve sheath tumors (MPNSTs) are aggressive malignancies of the peripheral nervous system. The majority of MPNSTs arise in patients of the autosomal dominant genetic disorder neurofibromatosis type I (NF1) although they also arise sporadically. In the absence of any effective chemotherapeutic options and with surgery constituting the mainstay of treatment, MPNST patients face an extremely poor prognosis. This underscores the need to develop novel therapeutic strategies against this tumor type. It is well accepted that the crosstalk between autophagy and apoptosis can be exploited to derive maximal therapeutic benefit, especially through combinatorial therapies. However, this interaction is extremely …

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The Effects Of Psychological Stress, Depressive Symptoms, And Cortisol On Body Mass And Central Adiposity In 10-To12-Year-Old Children, Hong-Thuy Lam Jan 2012

The Effects Of Psychological Stress, Depressive Symptoms, And Cortisol On Body Mass And Central Adiposity In 10-To12-Year-Old Children, Hong-Thuy Lam

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The percentage of children with elevated body mass and central adiposity has tripled in the U.S. over the past thirty years. While physical factors, such as decreased physical activity and poor nutrition, have been noted to influence elevated body mass and central adiposity in school-aged children, less is known about psychological factors, such as psychological stress and depressive symptoms, especially in 10-to12-year-old children. Further, it has been suggested that cortisol, a biomarker of psychological stress, plays a role in the underlying mechanism that links psychological stress and depressive symptoms to increased body mass and central adiposity, but this has not …

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Mechanism Of Nfi-C Functionin During Tooth Root Formation, Ejvis Lamani Jan 2012

Mechanism Of Nfi-C Functionin During Tooth Root Formation, Ejvis Lamani

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Currently, very little is known regarding tissue-specific gene regulation during the later stages of tooth development, especially those associated with root formation. Re-cent studies have identified nuclear factor I-C (NFI-C) as a critical factor for root for-mation in mammals. NFI-C functions as a cellular transcription factor and adenovirus DNA replication factor. Its role in root formation first became evident when Nfi-c null mice were shown to lack molar roots. A similar phenotype of incomplete or absent root formation is observed in patients with the autosomal dominant disease Radicular Dentin Dysplasia (RDD; MIM125400) also known as Rootless Teeth or Dentin Dysplasia …

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Development Of An Adenoviral Vector Platform For Selective Gene Delivery To Neurons, Travis Benjamin Lewis Jan 2012

Development Of An Adenoviral Vector Platform For Selective Gene Delivery To Neurons, Travis Benjamin Lewis

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Parkinson disease (PD) is a devastating movement disorder affecting between 500,000 and 1,000,000 individuals in the United States alone, and for which there is currently no cure. Therapies such as dopamine replacement help initially, but with disease progression these lose efficacy and do not alter the underlying degenerative process. Gene therapy is the delivery of exogenous genetic material to correct an underlying disorder. A major advantage of this approach is the ability to distribute potent therapies to specific targets over an extended duration, properties necessary for the treatment of progressive degenerative diseases such as PD. A number of clinical trials …

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Design Of An Underground Storage Tank Involving Water Collection For Water Reuse To Irrigate The Campus Green Area Of The Uab Campus, Zhuo Li Jan 2012

Design Of An Underground Storage Tank Involving Water Collection For Water Reuse To Irrigate The Campus Green Area Of The Uab Campus, Zhuo Li

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The UAB Campus Recreation Center is located in the Birmingham city block whose boundaries are University Blvd., 10th Avenue South, 14th Street South, and 16th Street South. The water supply of the UAB Campus Recreation Center is based on a natural underground water source, which is use such needs as pool water. The underground water is continuously pumped from its foundation in order to avoid flooding the basement of the Recreation Center. As a result, in addition to the water usage of the Recreation Center, the additional water pumped underground could be utilized to irrigate the campus green area. A …

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The Role Of The Mirror Neuron System In Mental State Attribution In Autism: An Fmri Study, Lauren E. Libero Jan 2012

The Role Of The Mirror Neuron System In Mental State Attribution In Autism: An Fmri Study, Lauren E. Libero

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The ability to interpret others' intentions based on their actions is a vital skill that helps us infer and understand their thoughts and plans. However, individuals with autism have been found to have difficulty in attributing intentions to others (Baron-Cohen et al., 1985; Baron-Cohen, 1995; Happe & Frith, 1996; Williams et al., 2001). The present study investigated the neural mechanisms of inferring intentions from actions in high-functioning adults with autism spectrum disorders (ASD) and typically developing control participants. fMRI data were acquired while participants made judgments about the means (how an action is performed) and intentions (why an action is …

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Regulation Of P27kip1 By Trip6 And Its Implications In Cancer Progression, Victor T G Lin Jan 2012

Regulation Of P27kip1 By Trip6 And Its Implications In Cancer Progression, Victor T G Lin

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TRIP6 is a focal adhesion molecule that functions as an adaptor protein to mediate diverse cellular functions, including motility and antiapoptotic signaling, through a wide variety of protein-protein interactions. We were able to characterize a novel interaction between TRIP6 and p27KIP1, a CDK inhibitor which can both suppress and promote tumorigenesis, depending on its regulation. TRIP6 expression specifically promotes the AKT-mediated phosphorylation of p27KIP1 at T157, which leads to its cytosolic retention, and accelerates the protein turnover rate of p27KIP1. We also found that phosphorylation of T157 by itself promotes cell motility and can be linked to the formation of …

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Multiscale Modeling Of The Mouse Femur, Shannon Lisenbee Jan 2012

Multiscale Modeling Of The Mouse Femur, Shannon Lisenbee

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This paper seeks to advance the knowledge base for bones and how they respond to mechanical stimuli through the use of multiscale modeling. First, a simple but effective approach for segmenting bone from computed tomography images using MATLAB is presented. Using edge detection and gradient operators to identify areas of bone within an image allows for much more accurate and consistent bone segmentation than simpler techniques like thresholding. This technique is applied to the femur of a female mouse for use in further modeling and testing. Next a representative volume element (RVE) for lamellar cortical bone is created based on …

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Regulation Of Membrane Traffic By The Big2 Member Of Guanine Nucleotide Exchange Factors, Jason Lowery Jan 2012

Regulation Of Membrane Traffic By The Big2 Member Of Guanine Nucleotide Exchange Factors, Jason Lowery

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Vesicular transport is an essential cellular process that facilitates the movement of molecules within a cell. The importance of vesicular transport is highlighted by numerous human diseases that result from mutations affecting protein trafficking. The Brefeldin A-inhibited guanine nucleotide exchange factor 2 (BIG2) has emerged as a key regulator of protein trafficking within the late secretory pathway, between the trans-Golgi Network (TGN) and endosomal compartments and within the recycling endosomal pathway. Mutations in BIG2 lead to Autosomal Recessive Periventricular Heterotopia with Microcephly (ARPHM), a disorder characterized by severe brain malformations. BIG2 stimulates nucleotide exchange of GDP for GTP on ADP-ribosylation …

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Regulation Of Alpha-Synuclein Accumulation By The Autophagy-Lysosome Pathway In A Preclinical Model Of Parkinson Disease, Leandra Rosa Mangieri Jan 2012

Regulation Of Alpha-Synuclein Accumulation By The Autophagy-Lysosome Pathway In A Preclinical Model Of Parkinson Disease, Leandra Rosa Mangieri

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Finding novel therapeutics that delay or halt the progression of Parkinson Disease (PD) is key to providing symptomatic relief of debilitating symptoms. A defining pathological feature of PD is characterized by the formation of Lewy bodies, intraneuronal inclusions comprised mainly of α-synuclein (ASYN) (4). Vacuolar ATPase (V-ATPase), an enzyme complex comprised of two multi-subunit-containing domains, critically regulates the acidification of vesicles such as lysosomes and thus proper function of the autophagy-lysosome pathway (ALP), which is critical for the degradation of ASYN. Compromises to V-ATPase have been shown to negatively affect lysosome function and its ability to clear toxic forms of …

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The Effects Of Venlafaxine On Functional Recovery Following Spinal Cord Injury, Don E. Mccormick Jan 2012

The Effects Of Venlafaxine On Functional Recovery Following Spinal Cord Injury, Don E. Mccormick

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Spinal cord injury (SCI) can significantly alter a person's physical and psychological health over their lifetime. Depression in persons with SCI is often treated with antidepressants which alter serotonergic and adrenergic signaling, both regulators of plasticity. However, the effects of antidepressants functional recovery after SCI have never been evaluated. Therefore, we hypothesize that antidepressant therapy would alter functional recovery and neuropathic pain behaviors in a SCI rodent model. The aim of this study was to evaluate the effects of venlafaxine (VEN) administration on functional recovery in the rehabilitation setting using a SCI rodent model. Adult male Sprague-Dawley rats received a …

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The Effects Of Direct To Consumer Advertising On Healthcare Utilization Among Medicaid Children With Asthma, Luceta C. Mcroy Jan 2012

The Effects Of Direct To Consumer Advertising On Healthcare Utilization Among Medicaid Children With Asthma, Luceta C. Mcroy

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National guidelines recommend treatment of asthma with preventive long term medication, but adherence remains low, resulting in high healthcare utilization among those affected by the chronic disease. The increase in DTCA since the easing of restrictions by the FDA in 1997 has prompted much debate on the effects of the DTCA, with critics arguing that it is harmful while proponents see many benefits such as increased medication adherence. This study examines the impact of DTCA on healthcare utilization and asthma medication use by combining Medicaid administrative data and a national advertising data set on asthma medication from 1999 to 2002. …

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Genome-Wide Dna Methylation Changes During Breast Tumorigenesis, Natalie E. Mitchell Jan 2012

Genome-Wide Dna Methylation Changes During Breast Tumorigenesis, Natalie E. Mitchell

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Neoplastic reprogramming generates cancerous cells from normal derivatives, enabling researchers to create a model of the early stages of oncogenesis and analyze molecular changes in real-time. Aberrations in DNA methylation are considered a major mechanism contributing to the acquisition and maintenance of a cancerous phenotype; however, little research exists regarding gene-specific changes in DNA methylation during the transition from a normal to neoplastic cell. Human mammary epithelial cells (HMECs) underwent neoplastic transformation through the addition of three defined genetic elements to generate one line of semi-transformed, pre-malignant cells (SHMECs) and two separate lines of fully transformed, malignant cells (THMECs). We …

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Socioeconomic Patterning Of Obesity Among African American Women In The Jackson Heart Study, Tonya Moore Jan 2012

Socioeconomic Patterning Of Obesity Among African American Women In The Jackson Heart Study, Tonya Moore

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Objectives: The purpose of this study was to expand upon what has been observed in literature about obesity and its ties to socioeconomic status (SES) among African American Women (AAW) participants of the Jackson Heart Study (JHS). Methods: This secondary analysis was a sub-study of the JHS and focused on four SES variables: education, income, occupation and wealth; and five outcome variables: body mass index (BMI), waist circumference (WC), waist-to-hip ratio (WHR), visceral adipose tissue (VAT), and subcutaneous adipose tissue (SAT). Two analytic samples were created in order to examine data collected during Exam 1 (2000-2004) and Exam 2 (2005-2008). …

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An Information Theoretical Modeling And Analysis Of Systems, Bunyamin Ozaydin Jan 2012

An Information Theoretical Modeling And Analysis Of Systems, Bunyamin Ozaydin

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The growth of the service industry also comes with problems and complications because of its inherent error proneness. As the complexity of systems increases, whether the system of interest is a service product or a natural phenomenon, it only proves that there is always a need for improved modeling approaches. In this study, we approach systems from an information theoretical perspective. More specifically, we model systems by noisy communication channels and analyze them by a structure of relationships whose elements are commonly used analysis tools in science and engineering. We call this modeling approach and the structure of relationships it …

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Using Mouse Models To Investigate Ciliopathies, Raymond Carl Pasek Jan 2012

Using Mouse Models To Investigate Ciliopathies, Raymond Carl Pasek

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Cilia and flagella are microtubule based organelles found on nearly every cell type in the mammalian body. Flagella have an essential role in sperm locomotion and reproduction, while motile cilia have a known role in fluid movement in the brain, lungs, and portions of the female reproductive tract. While the role of most primary cilia remained unknown for decades, they are now recognized as being essential to mammalian development, renal homeostasis, and satiety, just to name a few. Because of their widespread presence and importance, dysfunction of cilia and flagella can lead to a variety of human diseases, collectively referred …

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