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Utilization Of The Zebrafish Model System To Predict Effects Of Dietary Lipid Composition On Human Health, Lauren Adele Fowler Jan 2019

Utilization Of The Zebrafish Model System To Predict Effects Of Dietary Lipid Composition On Human Health, Lauren Adele Fowler

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Obesity is a disease that encompasses the interaction of both genetics and life-style factors, and the pathology behind its development remains unclear. Specifically, defining the influence of dietary lipid intake on adiposity and metabolic health continues to be a fundamental challenge, and the use of animal models will be required to gain a full understanding of the processes contributing to diet-induced obesity in humans. The zebrafish Danio rerio has emerged as a powerful model system to study diet-induced obesity and metabolic disease in humans, while simultaneously offering multiple advantages over rodent models. This dissertation addresses multiple aspects regarding the use …

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Nursing Staff Approaches To Providing Oral Hygiene In Stroke Survivors With Dysphagia: A Grounded Theory Study, Willard Edward Brewer Jan 2019

Nursing Staff Approaches To Providing Oral Hygiene In Stroke Survivors With Dysphagia: A Grounded Theory Study, Willard Edward Brewer

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The purpose of this qualitative grounded theory study was to explore how the nursing staff approaches oral hygiene in stroke survivors with dysphagia during the rehabilitation phase of recovery and what guides their decisions. Oral hygiene is a proven effective task known to prevent systemic health disparities (i.e. aspiration pneumonia, diabetes, gastrointestinal disparities, and even stroke). However, there are no current evidenced-based guidelines that provide instruction on how to execute oral hygiene to stroke survivors with dysphagia. Little is known about how nurses make decisions to implement oral hygiene in stroke survivors with dysphagia. Using a theoretical sampling strategy, data …

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Significance Of Acculturation, Assimilation, And Allostatic Load As Risk Factors For Obesity Among Hispanics, Yenni Elvia Cedillo Juare Jan 2019

Significance Of Acculturation, Assimilation, And Allostatic Load As Risk Factors For Obesity Among Hispanics, Yenni Elvia Cedillo Juare

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Obesity has increased during the last two decades in the United States (U.S.) and is considered a major risk factor for chronic diseases within the Hispanic community. The burden of obesity in Hispanics is associated with higher rates of morbidity and mortality and an increase in healthcare costs. Hispanics’ challenges after migration extend to subsequent generations, putting the population at risk for disease development. Specifically, migration can lead to the adoption of health behaviors, beliefs, values, and language of the host country, a process known as acculturation, which has been associated with changes in health behaviors. Among the Hispanic population, …

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Validity Of Actigraph Gt3x Accelerometer In Determining Energy Expenditure, Brandon Dean Beamon Jan 2019

Validity Of Actigraph Gt3x Accelerometer In Determining Energy Expenditure, Brandon Dean Beamon

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ABSTRACT The purpose of this investigation was to examine estimates of energy expenditure from the Actigraph GT3X tracking device compared to that obtained by indirect calorimetry. Twenty-seven healthy Caucasian males at the University of Alabama at Birmingham (age 20-30 y) with a BMI range of 19.5 and 30 kg/m2 were asked to wear an Actigraph GT3X on the wrist, hip, and ankle while performing exercise on a treadmill, bike, and upper body ergometer in randomized order. After twelve regressions divided into two sections 4 with ankle, hip, and wrist included in the model, and 4 with the ankle site omitted) …

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Physical Activity Promotion Among Adolescents With Pediatric Onset Multiple Sclerosis, Elizabeth Morghen Sikes Jan 2019

Physical Activity Promotion Among Adolescents With Pediatric Onset Multiple Sclerosis, Elizabeth Morghen Sikes

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Pediatric onset multiple sclerosis (MS) is a chronic and disabling disease of the central nervous system with an onset before 18 years of age. Youth with pediatric onset MS may benefit from physical activity as evidenced by past research suggestsing higher levels of physical activity are associated with reduced physical and psychosocial disease manifestations. Unfortunately, published estimates of physical activity participation among those with pediatric onset MS are very low (<10 min/day). This dissertation aimed to describe the current literature regarding physical activity among youth with pediatric MS, and to further explore experiences, patterns, correlates, and potential confounders of physical activity for the ultimate purpose of informing future behavior change interventions. Results are presented through five single study chapters. Briefly, interventions developed to promote physical activity for adolescents with pediatric onset MS should be individually tailored, include a strong social component, aim to educate regarding safety and outcomes of physical activity, and differentially target weekday and weekend day activity and sedentary behavior. Social cognitive theory (SCT) is an appropriate method for promoting physical activity behavior change among youth with pediatric onset MS, and SCT constructs including exercise goal setting, barriers self-efficacy, outcome expectations, and social support should be incorporated in the intervention as appropriate. Further, physical activity is seemingly an appropriate method for the management of functional limitations for youth with pediatric onset MS. Clinicians and researchers seeking to promote physical activity among those with pediatric onset MS may find this dissertation especially useful in providing a framework for the development of behavior change interventions.

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The Relationship Between Emotional Intelligence And Leadership Styles In School Principals, James Dale Stripling Jan 2019

The Relationship Between Emotional Intelligence And Leadership Styles In School Principals, James Dale Stripling

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THE RELATIONSHIP BETWEEN EMOTIONAL INTELLIGENCE AND LEADERSHIP STYLES IN SCHOOL PRINCIPALS EDUCATIONAL LEADERSHIP ABSTRACT This quantitative research study was designed to examine the relationship between emotional intelligence and leadership styles among principals and assistant principals in two districts located in central Alabama. There were 75 schools included. Seventy-two administrators participated. The surveys gauged the administrator’s emotional intelligence and leadership style. The emotional intelligence survey was designed by Daniel Goleman. The leadership style survey was designed by Peter Northouse. The participants also answered questions concerning their age, administrative experience and gender. After the surveys were returned, the data was entered into …

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Deciphering The Roles Of Hopd1 In Carbon Metabolism During Pathogen Infection, Yali Sun Jan 2019

Deciphering The Roles Of Hopd1 In Carbon Metabolism During Pathogen Infection, Yali Sun

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Plants are equipped with various immune responses including MAMP-triggered immunity (MTI) and effector-triggered immunity (ETI) to fight against pathogens, while virulent pathogens release virulent proteins (effectors) and phytotoxins to compete with host immune responses. Comprehensively, plant-pathogen interactions involve multi- layered and highly coordinated processes, and dynamic regulation at both transcriptional and translational levels plays a pivotal role in plant defense. For example, NPR1, a key immune regulator, is regulated by hosts and manipulated by pathogens at different levels during different stages of plant-pathogen interaction. However, besides the competition over immune responses, bacterial pathogens also need to gain nutrients from host …

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The Anti-Tumor Effects Of Hur Inhibition In Glioblastoma, Jiping Wang Jan 2019

The Anti-Tumor Effects Of Hur Inhibition In Glioblastoma, Jiping Wang

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Glioblastomas (GBMs) are the most malignant primary brain tumor. GBMs represent 14.7% of total primary CNS tumors and 47.7% of malignant CNS tumors. The median survival of GBM is 18-20 months, while five-year survival rate is only 5.6%. GBMs are maintained by glioma stem cells (GSCs), and poor treatment outcomes are linked to the high resistance of GSCs to radiation and chemotherapy, and the immunosuppressive tumor microenvironment. The mRNA binding protein HuR is a key regulator of tumor growth and development based upon the fact that HuR targets mRNAs that are broadly involved in tumorigenesis. We have previously shown that …

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Obesity In People With Spinal Cord Injury: Secondary Data Analysis Of National Spinal Cord Injury Database, Huacong Wen Jan 2019

Obesity In People With Spinal Cord Injury: Secondary Data Analysis Of National Spinal Cord Injury Database, Huacong Wen

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People with disabilities are 1.5-2.5 times more likely to be obese than those without disabling conditions. We have learned a lot about obesity in the general population. However, the neurological deficits of people with spinal cord injury (SCI) make it difficult to generalize the findings in the general population to the SCI population. Therefore, the purposes of this dissertation were to 1) assess racial differences in body mass index (BMI) change over 5 years; 2) evaluate the role of neighborhood in the relationship between race and obesity; 3) examine the impact of BMI at the time of injury on 1-year …

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Effects Of Protein Timing And Energy Balance On Body Composition In Collegiate Athletes, Ashley Licata Jan 2019

Effects Of Protein Timing And Energy Balance On Body Composition In Collegiate Athletes, Ashley Licata

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The current literature indicates that energy balance and protein consumption influence body composition. However, the effects of protein intake, timed protein supplementation, and energy balance on body composition have not yet been fully investigated in collegiate athletes. The purpose of this research was to assess collegiate athletes using hourly food and exercise data to examine how protein timing and energy balance relate to body composition. Aims 1 and 2 focus on collegiate female soccer athletes and further our understanding of the potential roles that protein amount and frequency and hourly energy balance play in optimizing fat mass and fat-free mass. …

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Insuring Graduation: An Analysis Of The Association Between Student Health Insurance And Graduation, John Robert Lovett Jan 2019

Insuring Graduation: An Analysis Of The Association Between Student Health Insurance And Graduation, John Robert Lovett

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Most college students have access to basic health services through their campus’ college health program. Unfortunately, students who lack health insurance may be limited in their access to health services beyond the acute care provided, which may manifest in a myriad of adverse outcomes; ultimately resulting in withdrawal from college without graduating. Student health insurance plans (SHIPs) are high-quality, affordable insurance plans specially designed to meet this need. This study utilized survival analysis to examine the temporal nature of college graduation behavior, as it related to student health insurance status. The results of this study show no significant relationship between …

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Examining Teachers' Perceptions And Practices Of Family Engagement With Families Of Emergent Bilinguals In Pre-Kindergarten And Kindergarten Classrooms: A Mixed Methods And Multiple Case Study, Julie I. Paul Jan 2019

Examining Teachers' Perceptions And Practices Of Family Engagement With Families Of Emergent Bilinguals In Pre-Kindergarten And Kindergarten Classrooms: A Mixed Methods And Multiple Case Study, Julie I. Paul

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This study addressed pre-K and kindergarten teachers’ perceptions and practices of family engagement with families of students who are Dual Language Learners/Emergent Bilinguals. The study employed an explanatory sequential mixed methods design (Quan --> QUAL) (Creswell & Plano-Clark, 2018). To address the purpose of the study, the overarching mixed methods question was: How do pre-K and kindergarten teachers engage families of all their students and families of students who are emergent bilinguals? Mixing of the strands occurred after the quantitative data was collected. Quantitative results helped develop the semi-structured interview protocol for the qualitative phase of the study. Qualitative results …

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Determination Of The Role Of Smu_833 In The Fitness And Virulence Of Cariogenic Streptococcus Mutans, Katherine Lynn Rainey Jan 2019

Determination Of The Role Of Smu_833 In The Fitness And Virulence Of Cariogenic Streptococcus Mutans, Katherine Lynn Rainey

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Dental caries, commonly known as tooth decay, is the most common infectious disease worldwide. The main etiological agent of dental caries is Streptococcus mutans which can readily form a biofilm on the surface of teeth and produce acids through the metabolism of dietary sugars, which is largely responsible for the demineralization and subsequent destruction of tooth enamel. In addition, S. mutans synthesizes extracellular glucosyltransferases (Gtfs) capable of breaking apart dietary sucrose and polymerizing the glucose subunits into the sticky glucan matrix of the biofilm, imperative for the formation of robust, three-dimensional biofilms. Currently used caries therapies are not species-specific and …

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Postpartum Body Composition And Breast Milk Hormones, Camille Schneider Jan 2019

Postpartum Body Composition And Breast Milk Hormones, Camille Schneider

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The prevalence of both adult and child obesity continues to rise. Children born to mothers with obesity have a greater risk for future obesity and chronic disease. There is an increasing body of literature suggesting that pregnancy and infancy are critical periods influencing the child’s risk for obesity. However, little is known about whether consumption of breast milk from an obese mother might influence the child’s metabolic programming and growth. The purpose of this dissertation was to examine the association of maternal adiposity with insulin and leptin in breast milk and, in turn, whether breast milk insulin, leptin, and glucose …

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Targeting The Nad Salvage Pathway For The Treatment Of The Parasitic Disease Schistosomiasis, Michael David Schultz Jan 2019

Targeting The Nad Salvage Pathway For The Treatment Of The Parasitic Disease Schistosomiasis, Michael David Schultz

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Schistosomiasis, also known as bilharzia, is the third most common parasitic infection worldwide and a major source of morbidity and mortality in developing countries. Caused by trematodes in the genus Schistosoma, this parasitic disease has no vaccine therapy and resources for drug development are scarce. Despite an unknown mechanism of action, praziquantal has become the primary source of treatment due to its efficacy against all species of Schistosoma. However, with increased drug resistance in endemic areas and low activity against immature parasites, relying on this single drug is unsustainable and risky. Hence, there is a growing need for new, safe …

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Examining The Impact Of Couple Relationship Factors On Male Engagement Pregnancy Health And Communal Coping, Pamela Musoke Jan 2019

Examining The Impact Of Couple Relationship Factors On Male Engagement Pregnancy Health And Communal Coping, Pamela Musoke

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Focusing on male partner engagement in HIV prevention is an important aspect of intervention and policy development and implementation within the sub-Saharan African context. However, engaging male partners safely and effectively to improve the impact and sustainability of HIV prevention modalities remains challenging due to continued impact of traditional gender roles that may affect the willingness and confidence to engage in pregnancy health. Additionally, the lack of knowledge of how best to engage in pregnancy health beyond financial support makes it difficult for male partners to engage. This dissertation’s overall aim is to explore aspects of male partner engagement's influences …

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Overcoming Obesity-Induced Immunotherapeutic Impairment, Shannon Boi Jan 2018

Overcoming Obesity-Induced Immunotherapeutic Impairment, Shannon Boi

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Obesity affects ~40% of United States adults and is linked to the development of multiple health-related complications. Obesity is a major risk factor for developing renal cell carcinoma (RCC), the most common type of renal cancer. Metastatic RCC has poor five-year survivals, therefore, new, efficacious therapeutics are needed. One avenue is immunomodulation to generate tumor-specific, systemic anti-tumor responses that are long-lasting against local, metastatic, and recurrent tumors. Despite encouraging results, immunotherapeutic treatment of RCC is underwhelming. Cytokine therapies are largely toxic, while newly FDA-approved ‘checkpoint blockade’ (CB) antibodies have responses <50%. Here, we present a strategy employing a T cell priming therapy (AdTR/CpG) upstream of CB administration. Combinatorial use resulted in improved anti-tumoral immune responses, significantly reduced tumor burdens, and extended overall survival in pre-clinical RCC. Importantly, this approach was more efficacious than either single agent(s). Pre-clinical therapy development is often accomplished using lean, healthy animals–thus, to improve translatability we examined immune responses in the context of obesity as a major patient comorbidity. Subsequently, we investigated AdTR/CpG/CB in diet-induced obese (DIO) mice. Tumor/treatment-naïve DIO mice exhibited obesity-associated features; i.e., increased leptin/insulin and serum cytokines. These effects were not dependent on high-fat diet administration as mice resistant to weight gain had minimal alterations in these factors, and were similar to mice maintained on standard chow. As previously identified, 80% of DIO mice bearing renal tumors failed to respond to AdTR/CpG. AdTR/CpG/CB-treatment dramatically improved response rates against DIO tumors, however, decreased obese responder percentages were observed in both combinatorial therapies and was independent of high fat diet administration alone. Impaired response rates were not model or immunotherapy-specific as similar reductions in tumor clearance were seen in models of melanoma and sarcoma. Furthermore, responses were not due to initial T cell priming or unequal precursor CD8+ T cell frequencies. Detrimental changes in the tumor microenvironment underscored failure in obese mice and revealed therapeutic success was defined by a T cell-myeloid cell-inversion profile, supported by immunogenetic and flow cytometric analyses. Thus, we demonstrate a novel combinatorial approach for improving checkpoint-based outcomes, and identify the ability of host obesity to impede therapy-induced anti-tumor immunity.

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Disaster Medical Preparedness In The Birmingham Metropolitan Community, Angela Hollowell Jan 2018

Disaster Medical Preparedness In The Birmingham Metropolitan Community, Angela Hollowell

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This research study aims to determine the presence of disaster medical preparedness in residents of the Birmingham metropolitan area. A concurrent collection of qualitative and quantitative data analysis was used to assess the perceived risk of a natural disaster, determine the socioeconomic status of residents, evaluate the health needs of residents, and examine the presence of disaster medical preparedness. Face-to-face interviews of research participants were conducted for six weeks at five churches: 6th Avenue Baptist Church, Avondale Church of Christ, Mountain Brook Community Church, Southside Church of God, and True Love Church of Ensley. In analyzing the results of the …

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Heart Failure In A Contemporary Biracial Cohort, Matthew Mefford Jan 2018

Heart Failure In A Contemporary Biracial Cohort, Matthew Mefford

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Heart failure (HF) is the inability of the heart to meet the perfusion needs of the body. HF is a leading contributor to the burden of cardiovascular disease (CVD) and remains a public health concern. Hypertension is a major modifiable risk factor for the prevention and management of HF. Hypertension develops earlier, is less controlled, and has a stronger association with some CVD and renal outcomes among blacks versus whites. These disparities may extend to HF. In addition, adults with HF often have complex treatment regimens due to multimorbidity, making medication adherence an issue. The goal of this dissertation was …

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Diet, Physical Activity, And Healthy Aging In People Living With Hiv, Josh Newson Muhammad Jan 2018

Diet, Physical Activity, And Healthy Aging In People Living With Hiv, Josh Newson Muhammad

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As life expectancy for people living with HIV (PLWH) has increased, healthy aging in this community has become an emerging public health concern. Although the benefits of adopting healthy diets and regular physical activity are well-documented, implementing strategies for lifestyle modifications among older PLWH remains a challenge. The complex milieu of social, physiological and economic burdens encountered by PLWH exposes this population to increased risk for adverse health outcomes, especially from preventable metabolic diseases. The interaction of diet, physical activity and social determinants of health in persons who are HIV positive is an understudied area. The aim of this dissertation …

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Immune Modulation Of Pain And Recovery Via Diet, Stacie Totsch Jan 2018

Immune Modulation Of Pain And Recovery Via Diet, Stacie Totsch

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Chronic pain is the most common disability in the United States. Additionally, one out of three adults in America are obese and obesity and pain are often comorbid. Obesity is an inflammatory state due to the release of pro-inflammatory mediators from adipose tissue. Generally, obesity is a result of a poor-quality diet. Specific dietary components and patterns are independent activators of the immune system and can exacerbate the obesity-induced inflammatory state. It is known that immune system activation is a critical aspect in the development and progression of many chronic pain conditions. To address a general lack of preclinical investigations …

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Reaching Consensus On Global Health Nursing Competencies For Baccalaureate Nursing Education In The United States: A Delphi Method Study, Herica Maria Torres-Alzate Jan 2018

Reaching Consensus On Global Health Nursing Competencies For Baccalaureate Nursing Education In The United States: A Delphi Method Study, Herica Maria Torres-Alzate

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The purpose of this study was to reach consensus among experts on global health competencies for baccalaureate nursing students in the United States. A Nursing Global Health Competencies Framework (NGHCF) was created to guide identification of the domains and competencies for BSN nursing education. A three-round modified Delphi study intersected with a mixed methods research approach to reach consensus from experts in global health on essential global health competencies in nursing. The first phase revised the original list of competencies based on: (a) qualitative responses to the surveys conducted by Wilson et al. (2012), Ventura et al. (2014), and Warren …

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Factors Assocaited With Sedentary Lifestyle In Women Participants In Calm (Counseling And Lifestyle Management) Study, Amber Watts Jan 2018

Factors Assocaited With Sedentary Lifestyle In Women Participants In Calm (Counseling And Lifestyle Management) Study, Amber Watts

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Significant evidence has identified the importance of physical activity to the overall health and reduction in disease among humans. The World Health Organization (WHO) has implemented physical activity recommendations as guidelines to increase physical activity among the world population. However, evidence continues to show high levels of self-reported physical inactivity and growing prevalence of related chronic diseases (i.e. type 2 diabetes, stroke, and obesity), particularly among women. To increase participants߀™ knowledge of the benefits of physical activity and reduction of barriers continues to be focal point of interventions. However, studies indicate including more social, theory and cognitive aspects to these …

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Combinatorial Withaferin A And Sulforaphane And Their Potential Roles In Breast Cancer Prevention And Therapy, Kendra Jeanine Royston Jan 2018

Combinatorial Withaferin A And Sulforaphane And Their Potential Roles In Breast Cancer Prevention And Therapy, Kendra Jeanine Royston

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Cancer is a leading cause of death worldwide and is a devastating disease. Breast cancer is of particular interest because it is a major cause of cancer-related fatality in women in the United States. To date, more than 40,000 women are expected to die due to breast cancer and more than 200,000 will be diagnosed every year. Despite numerous advancements in the field, breast cancer remedies can be harsh and while life may be prolonged, the quality of life may decrease. This being said, preventive measures and less harsh treatment options are needed to help eliminate breast cancer as a …

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Molecular Characterization Of The Rare Cftr Mutation P67l As A Model For Genotype-Specific Drug Development And Personalized Medicine In Cystic Fibrosis, Carleen Mae Pomperada Sabusap Jan 2018

Molecular Characterization Of The Rare Cftr Mutation P67l As A Model For Genotype-Specific Drug Development And Personalized Medicine In Cystic Fibrosis, Carleen Mae Pomperada Sabusap

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The traditional CFTR functional defect subcategories (i.e. protein misfolding, gating, conductance, etc.) are sometimes inadequate for determining patients most likely to benefit from emerging modulator treatment. We employ the P67L variant as emblematic of ways a thorough biochemical analysis of a rare CF defect can guide new therapeutic approaches, help predict drug response, and facilitate clinical precision. Historically, P67L has been designated a class IV conductance abnormality (i.e., malformed ion pore). In contrast, our studies demonstrate P67L disrupts CFTR protein maturation, prompts misfolding, causes gating defects, and exhibits wild-type like conductance. We show that P67L CFTR is robustly rescued by …

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Understanding The Role Of Social Media In Breastfeeding: A Mixed Methods Study, Kara Skelton Jan 2018

Understanding The Role Of Social Media In Breastfeeding: A Mixed Methods Study, Kara Skelton

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Background: Breastfeeding is well known as the optimal source of nutrition for the first year of life. However, suboptimal exclusively breastfeeding rates in the US are still prevalent despite numerous calls to action at the national level. A mixed-methods study was conducted to explore social media group’ impact on breastfeeding related knowledge, attitudes and behaviors. Participants were recruited from one online social media pro-breastfeeding group. Online Focus Group Discussions (FGDs) were conducted with 21 women; Key Informant Interviews were conducted with 12 mothers. Qualitative data were aggregated for thematic analysis. A survey was developed based on findings from the qualitative …

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The Influence Of Child, Parent, And Context Factors On Children’S Traffic Injury Risk, Emma Sartin Goodman Jan 2018

The Influence Of Child, Parent, And Context Factors On Children’S Traffic Injury Risk, Emma Sartin Goodman

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Child restraint systems, like car seats and booster seats, are effective at preventing serious injury and death for children involved in motor vehicle collisions. Despite this, the majority of families in the United States either do not use, or incorrectly use, child restraint systems. Further, racial minorities are consistently reported to have higher rates of child restraint system non- and misuse than their White peers; research has yet to explain this relationship with previously hypothesized factors (e.g., caregiver education, sources of information). The overall objective of this project was to explain how child, caregiver, and context factors interacted to influence …

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Examining Kindergarten Teachers' Beliefs About And Implementation Of School, Family, And Community Partnerships In Saudi Arabia, Najla Albaiz Jan 2018

Examining Kindergarten Teachers' Beliefs About And Implementation Of School, Family, And Community Partnerships In Saudi Arabia, Najla Albaiz

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The research examined kindergarten teachers’ beliefs and implementation of school, family, and community partnerships (SFCPs) in Riyadh City, Saudi Arabia. It used Epstein’s model of SFCPs including the following practices: parenting, communicating, volunteering, learning at home, decision-making, and collaborating with the community. Two strands were employed: the quantitative obtained teachers’ beliefs and implementation of the SFCP practices by surveying a sample of 266 teachers from 126 public kindergartens. The follow up qualitative strand included a purposeful sample of 12 teachers to explore their experiences with SFCPs within three different social and economic areas (SEAs): High, middle, and low SEAs. Two-way …

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Examining The Relationship Between Teacher Beliefs, Prekindergartener’S Self-Regulation And Classroom Quality: Informing Professional Development Programs, Cailin Jane Kerch Jan 2018

Examining The Relationship Between Teacher Beliefs, Prekindergartener’S Self-Regulation And Classroom Quality: Informing Professional Development Programs, Cailin Jane Kerch

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The purpose of this convergent parallel, mixed methods study was to examine and explore the relationship between subjective teacher beliefs, classroom quality, and pre-kindergartener’s self-regulatory abilities within a publicly funded pre-kindergarten program. Teacher subjective beliefs (beliefs of classroom management, classroom practice, and beliefs of children) were studied operantly using Q-Methodology, in addition to, audio-recorded focus groups to explore the lived experience of teachers within the sample (n = 20). Classroom quality was measured using the Classroom Assessment Scoring System (CLASS) and pre-kindergartener’s self-regulatory abilities were studied using pre/post proxy items from the Devereux Early Childhood Assessment for Preschoolers, Second Edition …

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The Effects Of Glucose And Amino Acid Restriction On Protein Turnover And Micro-Rna Composition In The Muscle Of Rainbow Trout, Mary Neslund Latimer Jan 2018

The Effects Of Glucose And Amino Acid Restriction On Protein Turnover And Micro-Rna Composition In The Muscle Of Rainbow Trout, Mary Neslund Latimer

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Changes in nutritional status, through glucose and amino acid restriction, have the ability to augment both the protein turnover and micro-RNA (miR) composition in the skeletal muscle of rainbow trout in vitro and in vivo. In vitro, the restriction of glucose in the media for a period of 24h was able to reduce protein synthesis by 41.2% compared to control conditions. In addition, 48h of glucose restriction affected the expression of both mstn2a and igfbp5, genes involved in muscle growth dynamics and synthesis. The restriction of amino acids, specifically the amino acid methionine, in vitro was able to reduce the …

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