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Integrative Genomics Implicates Disruption Of Prenatal Neurogenesis In Congenital Hydrocephalus, Shreyas Panchagnula Jan 2021

Integrative Genomics Implicates Disruption Of Prenatal Neurogenesis In Congenital Hydrocephalus, Shreyas Panchagnula

Yale Medicine Thesis Digital Library

Congenital Hydrocephalus (CH) affects 1/1000 live births and costs the US healthcare system over $2 billion annually. Mainstay therapies, hinging on surgical cerebrospinal fluid diversion, exhibit high failure rates and substantial morbidity. Limited understanding of pathogenesis warrants identification of crucial genetic drivers underlying CH and their impact on brain development. This pioneering study integrates gene discovery from the largest whole-exome sequenced CH cohort with transcriptional networks (modules) and cell-type markers from the latest transcriptomic atlases of the mid-gestational human brain to uncover the genomic and molecular architecture of CH. Exome analysis of 381 radiographically-confirmed, neurosurgically-treated sporadic CH probands (including 232 …


Conscious Sedation Medication Choice Does Not Affect Outcomes After Transcatheter Aortic Valve Replacement, Diane Rm Somlo Jan 2021

Conscious Sedation Medication Choice Does Not Affect Outcomes After Transcatheter Aortic Valve Replacement, Diane Rm Somlo

Yale Medicine Thesis Digital Library

Conscious Sedation (CS) has become a mainstay option for anesthesia in Transcatheter Aortic Valve Replacement (TAVR), but there has been limited investigation into the effect of CS medication choice on patient outcomes. This study aimed to assess whether the CS medications used in TAVR were associated with primary outcomes, including hospital length of stay (LOS), mortality, or need for post-operative permanent pacemaker. This retrospective, observational study included 272 patients who underwent TAVR with CS at a tertiary teaching hospital between September 2014 and December 2017. Patient and procedure data were collected from the STS/ACC Transcatheter Valve Therapy Registry and chart …


Somatic Gja4 Mutation In Vascular Malformations Reveals A Novel Pathway For Vascular Neoplasia, Nelson C. Ugwu Jan 2021

Somatic Gja4 Mutation In Vascular Malformations Reveals A Novel Pathway For Vascular Neoplasia, Nelson C. Ugwu

Yale Medicine Thesis Digital Library

The term “cavernous hemangioma” has been used to describe vascular anomalies with histology featuring dilated vascular spaces, vessel walls consisting mainly of fibrous stromal bands lined by a single layer of flattened endothelial cells, and a variably irregular outer rim of interrupted smooth muscle cells. Hepatic hemangiomas (HH) and cutaneous venous malformations (cVM) share this histologic pattern, and we examined lesions in both tissues to identify genetic drivers. Paired WES of lesional tissue and normal liver in HH subjects revealed a recurrent GJA4 c.121G>T, p.Gly41Cys somatic mutation in four of five unrelated cases, and targeted sequencing in paired tissue …


Achieving Healthequity: A Role For Nurse Leaders On Nonprofit Boards, Bernie Park Jan 2021

Achieving Healthequity: A Role For Nurse Leaders On Nonprofit Boards, Bernie Park

Yale School of Nursing Digital Theses

Diverse board leadership plays a key role in effective local and community nonprofit organizations. Nurses with core governance competencies are uniquely positioned to serve on boards of the nonprofit organizations in the communities that they already live and work in, especially but not exclusively when those organizations focus on improving health care outcomes and advancing health promotion. While the nurse of the future (IOM, 2010) is called on to lead, nurses often do not perceive themselves as being successful in governance roles (Sundean et al., 2019). This paper describes a pilot project with the Connecticut Nurses Association (SpringBoard to Board …


The Role Of Knowledge In End-Of-Life Decision-Making By Older Persons, Laura Van Dyck Jan 2021

The Role Of Knowledge In End-Of-Life Decision-Making By Older Persons, Laura Van Dyck

Yale Medicine Thesis Digital Library

As physicians, we aim to support our patients to engage in and make end-of-life medical decisions. Ideally, patients engage in advance care planning (ACP) to direct their care if they become incapable of participating in decision-making. For many patients, however, their first encounter with end-of-life care—e.g. code status—occurs at hospital admission. This thesis describes two studies: the ACP Study and Code Status Study. The ACP Study examines ACP knowledge and its relationship to engagement. This study utilizes baseline data from 921 participants age 55 years enrolled in the STAMP randomized controlled trial, including a knowledge scale consisting of 7 questions …


Investor Relations, United States: Federal Home Loan Bank Of Des Moines Jan 2021

Investor Relations, United States: Federal Home Loan Bank Of Des Moines

Documents

No abstract provided.


The Politics Of Last Resort Lending And The Overend & Gurney Crisis Of 1866, Sabine Schneider Jan 2021

The Politics Of Last Resort Lending And The Overend & Gurney Crisis Of 1866, Sabine Schneider

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No abstract provided.


Financial Dollarization And De-Dollarization In The New Millennium, Eduardo Levy Yeyati Jan 2021

Financial Dollarization And De-Dollarization In The New Millennium, Eduardo Levy Yeyati

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No abstract provided.


Cost Of Banking Stabilization Measures As At End-2018, Ireland: Comptroller And Auditor General Jan 2021

Cost Of Banking Stabilization Measures As At End-2018, Ireland: Comptroller And Auditor General

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No abstract provided.


Main Street Lending Program Dashboard, Federal Reserve System: Federal Reserve Bank Of Boston Jan 2021

Main Street Lending Program Dashboard, Federal Reserve System: Federal Reserve Bank Of Boston

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No abstract provided.


Riksbank Takes Sustainability Into Account When Purchasing Corporate Bonds, Peter Sellin Jan 2021

Riksbank Takes Sustainability Into Account When Purchasing Corporate Bonds, Peter Sellin

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No abstract provided.


Rules Of Procedure And Instructions For Sveriges Riksbank, Sveriges Riksbank Jan 2021

Rules Of Procedure And Instructions For Sveriges Riksbank, Sveriges Riksbank

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No abstract provided.


Canadian Dollar Security 1m, Bloomberg L.P. Jan 2021

Canadian Dollar Security 1m, Bloomberg L.P.

Documents

data showing one-month Canadian overnight index swap rates


Canadian Dollar Offered Rate 1m, Renfinitiv Jan 2021

Canadian Dollar Offered Rate 1m, Renfinitiv

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data showing the one-month CDOR rate


Annual Report 2020, Bank Of Thailand Jan 2021

Annual Report 2020, Bank Of Thailand

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No abstract provided.


Greece Credit Ratings, Fitch Ratings Jan 2021

Greece Credit Ratings, Fitch Ratings

Documents

Web page showing credit ratings for Greek sovereign debt


Long-Term Government Bond Yields: 10-Year, Organisation For Economic Co-Operation And Development (Oecd) Jan 2021

Long-Term Government Bond Yields: 10-Year, Organisation For Economic Co-Operation And Development (Oecd)

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Monthly data recording the yields of 10-year government bods issued by selected eurozone countries; each series identifier can be constructed using ISO-3166-1 alpha-2 codes


Daily Liquidity Conditions, European Central Bank (Ecb) Jan 2021

Daily Liquidity Conditions, European Central Bank (Ecb)

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data showing liquidity programs in the Eurosystem


History Of All Ecb Open Market Operations, European Central Bank (Ecb) Jan 2021

History Of All Ecb Open Market Operations, European Central Bank (Ecb)

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Dataset of open-market operations: rates, dates, volumes, and procedures


Eonia And Euribor, Banque De France/Central Bank Of France Jan 2021

Eonia And Euribor, Banque De France/Central Bank Of France

Documents

Daily EONIA and EURIBOR rates


Monetary Authority; Loans To Domestic Banks Through The Discount Window; Asset, Level, Federal Reserve System: Federal Reserve Bank Of St. Louis Jan 2021

Monetary Authority; Loans To Domestic Banks Through The Discount Window; Asset, Level, Federal Reserve System: Federal Reserve Bank Of St. Louis

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No abstract provided.


The Republic Of Iceland's Sovereign Credit Rating, Central Bank Of Iceland Jan 2021

The Republic Of Iceland's Sovereign Credit Rating, Central Bank Of Iceland

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No abstract provided.


Bank Of Greece Balance Sheet, Changing Composition, Bank Of Greece/Central Bank Of Greece, Corey N. Runkel Jan 2021

Bank Of Greece Balance Sheet, Changing Composition, Bank Of Greece/Central Bank Of Greece, Corey N. Runkel

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spreadsheet detailing the BOG's monthly balance sheets


Monetary Policy Report - Second Half Of 2020, Bank Of Israel Jan 2021

Monetary Policy Report - Second Half Of 2020, Bank Of Israel

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No abstract provided.


Financial Institutions Guarantee Fund (Fogafin) - Who Are We?, Colombia: (Fogafin) Financial Institutions Guarantee Fund Jan 2021

Financial Institutions Guarantee Fund (Fogafin) - Who Are We?, Colombia: (Fogafin) Financial Institutions Guarantee Fund

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No abstract provided.


Clearing And Settlement Systems, Bank Of Canada/Central Bank Of Canada/La Banque Du Canada Jan 2021

Clearing And Settlement Systems, Bank Of Canada/Central Bank Of Canada/La Banque Du Canada

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No abstract provided.


Monetary Policy Report - January 2021, Bank Of Canada/Central Bank Of Canada/La Banque Du Canada Jan 2021

Monetary Policy Report - January 2021, Bank Of Canada/Central Bank Of Canada/La Banque Du Canada

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No abstract provided.


Monetary Policy And Central Banking In The Covid Era, William "Bill" English, Kristin Forbes, Angel Ubide Jan 2021

Monetary Policy And Central Banking In The Covid Era, William "Bill" English, Kristin Forbes, Angel Ubide

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No abstract provided.


Government Securities Auctions, Bank Of Canada/Central Bank Of Canada/La Banque Du Canada Jan 2021

Government Securities Auctions, Bank Of Canada/Central Bank Of Canada/La Banque Du Canada

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No abstract provided.


Provincial Money Market Purchase Program, Bank Of Canada/Central Bank Of Canada/La Banque Du Canada Jan 2021

Provincial Money Market Purchase Program, Bank Of Canada/Central Bank Of Canada/La Banque Du Canada

Documents

No abstract provided.