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Regulation Of Th17 Cells During Inflammatory Disorders, Hao Xu Apr 2022

Regulation Of Th17 Cells During Inflammatory Disorders, Hao Xu

Yale Graduate School of Arts and Sciences Dissertations

A balance between immunity against pathogens and tolerance to non-harmful stimuli is carefully maintained by our immune system under homeostatic conditions. Effector CD4+ T cells, particularly TH17 cells, are one of the major immune cell types that surveil mucosal homeostasis by producing pro-inflammatory cytokines, including IL-17A and IFN. However, when the immune balance is disrupted, massive numbers of TH17 cells infiltrate different tissues and organs, leading to a series of inflammatory disorders, such as inflammatory bowel diseases (IBDs) and multiple sclerosis (MS). Therefore, TH17 cells must be carefully monitored by multiple regulatory machineries, which are compromised or overridden by other …

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Modeling Large-Scale Copper Recycling To Support Transition To Sustainable Economy, Tong Wang Apr 2022

Modeling Large-Scale Copper Recycling To Support Transition To Sustainable Economy, Tong Wang

Yale Graduate School of Arts and Sciences Dissertations

Copper offers superior electrical and thermal conductivity leading to its use in a variety of applications. As a result of its increased use in buildings and rapidly growing use in clean energy and transportation, copper demand has more than doubled in the past 40 years. The primary production of copper results in substantial adverse environmental impacts including energy and water consumption, human toxicity, etc., which may increase as copper ore grades decline. Meanwhile, less than 30% of the total copper use can be substituted by aluminum, plastics, and optical fiber while maintaining the same level of performance. Therefore, researchers and …

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Trinity Of Geobacter Filaments: Discovery And Characterization Of Omcs, Omcz, And Pili Filaments, Yangqi Gu Apr 2022

Trinity Of Geobacter Filaments: Discovery And Characterization Of Omcs, Omcz, And Pili Filaments, Yangqi Gu

Yale Graduate School of Arts and Sciences Dissertations

Common soil bacterium Geobacter sulfurreducens is actively involved in a wide range of globally important phenomena, including element recycling, bioremediation, corrosion, and energy conversion. Their outstanding ability to engage long-range extracellular electron transfer (EET) has invoked great interest from researchers around the world. It was proposed 15 years ago that EET in Geobacter is supported by the filamentous appendages, usually referred to as “microbial nanowires”, which deliver electrons from inside the cell to the extracellular environment. Based on the genome organization and genetic studies, the identity of the nanowires was speculated to be type IV pili made up of a …

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Identifying Novel Strategies To Augment Anti-Melanoma Immunity, Meaghan K. Mcgeary Apr 2022

Identifying Novel Strategies To Augment Anti-Melanoma Immunity, Meaghan K. Mcgeary

Yale Graduate School of Arts and Sciences Dissertations

Melanoma is the deadliest form of skin cancer and caused the deaths of over 7,000 people in the United States in 2021. While immunotherapies have revolutionized care and extended survival for melanoma patients, most will either not respond or eventually develop resistance to these treatment options. Therefore, there is an urgent need to improve our understanding of the biology underlying the immune response to melanoma, and indeed to all cancers. We performed a whole-genome CRISPR screen in an immunogenic mouse model of melanoma to identify tumor intrinsic-factors that modulate the anti-tumor immune response. We identified several pathways of interest, including …

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On The Surveillance And Spread Of Drug Resistant Malaria In Sub-Saharan Africa, Hanna Y. Ehrlich Apr 2022

On The Surveillance And Spread Of Drug Resistant Malaria In Sub-Saharan Africa, Hanna Y. Ehrlich

Yale Graduate School of Arts and Sciences Dissertations

Artemisinin-based combination therapies (ACTs) are among the most important tools in our arsenal to treat and control malaria. ACTs and other antimalarial drugs have contributed to significant declines in global malaria-attributed morbidity and mortality over the past few decades. However, progress is the effort to eradicate the disease has not been equally distributed: sub-Saharan Africa continues to experiences the vast majority of the burden of the disease. Recent reports of ACT resistance in Rwanda and Uganda confirm longstanding expectations that artemisinin-resistant parasites will eventually emerge in Africa. To delay the spread of artemisinin resistance across the malaria endemic sub-continent, it …

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Motion-Based Spatial Vision In Drosophila: Connecting Canonical Levels Of Understanding In Neuroscience, Ryosuke Tanaka Apr 2022

Motion-Based Spatial Vision In Drosophila: Connecting Canonical Levels Of Understanding In Neuroscience, Ryosuke Tanaka

Yale Graduate School of Arts and Sciences Dissertations

A canonical metatheoretical framework in neuroscience states that, for one to understand a brain, parallel descriptions at the levels of computational theory, algorithms, and implementations, are necessary. However, computational goals of a brain are less empirically accessible than its algorithms or mechanisms, making analyses at the theoretical level challenging. The present thesis proposes that studying spatial vision problems in fruit fly Drosophila can be an interesting model case where one can bridge the computation theoretical and the other levels, aided by simple geometry of spatial vision problems as well as sophisticated circuit dissection tools in Drosophila. Chapter 2 explores how …

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Single Particle Tracking Covariance Analysis With Applications To Studying Chromatin Dynamics, Mary Lou Padlan Bailey Apr 2022

Single Particle Tracking Covariance Analysis With Applications To Studying Chromatin Dynamics, Mary Lou Padlan Bailey

Yale Graduate School of Arts and Sciences Dissertations

The chromosomes - DNA polymers and their binding proteins - are compacted into aspatially organized, yet dynamic, three-dimensional structure. Recent genome-wide chromatin conformation capture experiments reveal a hierarchical organization of the DNA structure that is imposed, at least in part, by looping interactions arising from the activity of loop extrusion factors. The dynamics of chromatin reflects the response of these polymers to a combination of thermal fluctuations and active processes. However, how chromosome structure and enzymes acting on chromatin together define its dynamics remains poorly understood. In the first part of this thesis, I present my work that combines high-precision …

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Essays In Macroeconomics And Finance, Ahyan Panjwani Apr 2022

Essays In Macroeconomics And Finance, Ahyan Panjwani

Yale Graduate School of Arts and Sciences Dissertations

This dissertation consists of three essays on the topics of macroeconomics, finance, and climate change. In the first essay I examine how two government policies implicitly encourage homeownership in areas increasingly threatened by climate change. First, the government spends billions of dollars helping rebuild homes and infrastructure after major disasters. Second, government-sponsored enterprises, Fannie Mae and Freddie Mac, do not charge mortgage borrowers for location-specific climate risk. In this paper, I introduce climate risk into a canonical lifecycle model of consumption and housing choice to estimate how removing both distortions would affect the number of homeowners living in areas exposed …

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Fundamental Studies Of The Reactivity Of Transition Metal Hydrides With Carbon Dioxide And Related Hydride Acceptors, Matthew Espinosa Apr 2022

Fundamental Studies Of The Reactivity Of Transition Metal Hydrides With Carbon Dioxide And Related Hydride Acceptors, Matthew Espinosa

Yale Graduate School of Arts and Sciences Dissertations

This dissertation describes the mechanistic investigation of hydride transfer from transition metal hydrides to carbon dioxide and related hydride acceptors. Hydride transfer is studied through both empirical methods that use structure-activity relationships and, quantitative thermodynamic and kinetic studies that focus on fundamental reactivity. Chapter 1 provides a review of work done to understand the reactivity of metal hydrides. It discusses empirical structure activity relationships developed with transition metal hydrides bound by a pincer ligand. This chapter also covers thermodynamic and kinetic hydricity and how they have been used to investigate the reactivity of metal hydrides. It ends with a brief …

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The Function Of Kiaa0319 In Human Neuronal Development, Steven Paniagua Apr 2022

The Function Of Kiaa0319 In Human Neuronal Development, Steven Paniagua

Yale Graduate School of Arts and Sciences Dissertations

Reading Disability (RD), also known as dyslexia, is defined as difficulty processing written language in individuals with normal intellectual capacity and educational opportunity. The prevalence of RD is between 5% and 17%, and the heritability ranges from 44% to 75%. Genetic linkage analysis and genome-wide association studies (GWAS) have identified several genes and regulatory elements linked to RD and reading ability. However, their functions and molecular mechanisms are not well understood. Prominent among these is KIAA0319, encoded in the DYX2 locus of human chromosome 6p22. Association of KIAA0319 has been independently replicated in multiple independent studies and languages. Rodent models …

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Incorporating Ancestry Information Into Association Studies Provides New Insights Into The Genetic And Epigenetic Architecture Of Smoking Trajectory, Boyang Li Apr 2022

Incorporating Ancestry Information Into Association Studies Provides New Insights Into The Genetic And Epigenetic Architecture Of Smoking Trajectory, Boyang Li

Yale Graduate School of Arts and Sciences Dissertations

Tobacco smoking is a leading cause of morbidity and mortality and the most preventable cause of a wide range of medical conditions and diseases. Studies showed that smoking was associated with both the genetic predisposition and DNA methylation signatures. To date, association studies have identified thousands of genetic variations and epigenetic alterations associated with smoking behavior. However, a large number of existing studies focused on a single ancestry group, mostly samples of European descent. Furthermore, a majority of the commonly used phenotypes including contrasts of smoking status (e.g. smoking initiation, smoking cessation) and quantitative phenotypes (e.g. pack-year, number of cigarettes …

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Tracking Carbon Cycle Behavior And Weathering Feedbacks Through Earth’S History Using Metal Isotope Proxies, Joachim Katchinoff Apr 2022

Tracking Carbon Cycle Behavior And Weathering Feedbacks Through Earth’S History Using Metal Isotope Proxies, Joachim Katchinoff

Yale Graduate School of Arts and Sciences Dissertations

The balance between carbon inputs – via degassing and breakdown of organic carbon – and outputs – via silicate weathering and organic carbon burial – on Earth dictate the concentration of atmospheric carbon dioxide (pCO2), which in turn, plays a major role in temperature and habitability in Earth’s past and future. Our understanding of Earth’s global carbon cycle and the processes that control it hinges, in part, on the tools and models that we use to track and reconstruct previous climates and environmental change. In this dissertation, I will present both empirical- and model-driven studies that contribute alternative and more …

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Essays On Chinese Foreign Lending, James Sundquist Apr 2022

Essays On Chinese Foreign Lending, James Sundquist

Yale Graduate School of Arts and Sciences Dissertations

What does the rise of Chinese lending to foreign governments mean for developing and developed countries? Recent progress in cataloguing Chinese loans and describing their differences from Western-led lending has not led to greater consensus among answers to this question. Broad frames such as ``debt-trap diplomacy'' have been criticized for overstepping their bounds of empirical support, while narrower studies frequently treat China as sui generis, rather than connecting their findings to open debates in political economy. Drawing on newly-developed methodology and original data collection, this dissertation refines our understanding of the causes and consequences of Chinese foreign lending. Specifically, I …

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From Moral Degeneration To Social Negotiation: Deception And Mindreading In Late Imperial Chinese Drama, Yun Bai Apr 2022

From Moral Degeneration To Social Negotiation: Deception And Mindreading In Late Imperial Chinese Drama, Yun Bai

Yale Graduate School of Arts and Sciences Dissertations

This dissertation explores how deception makes explicit the unspoken grounds on which seventeenth-century Chinese chuanqi dramatists made sense of the class conflicts and moral fluidity in their society. In seventeenth-century China, commerce sent scammers and forgeries to every corner of the country, frequent political conflicts forced officials into duplicity, and along with the new plasticity of social identity, the notion of social imposture came to the fore. Concurrently, the booming publishing industry allowed anxieties about deception to run free on the page. Seventeenth-century China was not only an age of deception, but also the period that produced the most writings …

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The Role Of Endogenous Retroviruses In Shaping The Host Anti-Viral Immunity, Yexin Yang Apr 2022

The Role Of Endogenous Retroviruses In Shaping The Host Anti-Viral Immunity, Yexin Yang

Yale Graduate School of Arts and Sciences Dissertations

One unique feature of retroviruses among other virus genre is their capability of reverse-transcribing their genetic material and integrating into the host genome. In the short term at the scale of the host life span, integrated proviruses became a genetic reservoir for chronic viral infection. In the long term at the scale of species evolution, proviruses integrated into the germ cells accumulate and comprise a substantial portion of the host genome, and became endogenous retroviruses (ERVs). Up to 10% of the vertebrate genome are remnants of such ancient genetic invaders. It is well established that the host immune system co-evolved …

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Intrathecal Delivery Of Nanoparticles For Treatment Of Metastatic Medulloblastoma, Minsoo Khang Apr 2022

Intrathecal Delivery Of Nanoparticles For Treatment Of Metastatic Medulloblastoma, Minsoo Khang

Yale Graduate School of Arts and Sciences Dissertations

The morbidity associated with pediatric medulloblastoma, particularly in patients who develop leptomeningeal metastases, remains high in the absence of effective therapies. Administration of substances directly into the cerebrospinal fluid (CSF) is one approach to circumvent the blood brain barrier (BBB) and focus delivery of drugs to the site of tumor, but high rates of CSF turnover prevent adequate drug accumulation and lead to rapid systemic clearance and toxicity. Here, we show that the nanoparticle encapsulation of talazoparib (BMN-673) significantly improves the therapeutic index when delivered intrathecally and leads to sustained drug retention at tumor site. We demonstrate that administration of …

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Improving Paleoclimate Reconstructions Using Models And Observations Of Foraminifera, Daniel E. Gaskell Apr 2022

Improving Paleoclimate Reconstructions Using Models And Observations Of Foraminifera, Daniel E. Gaskell

Yale Graduate School of Arts and Sciences Dissertations

This study investigates the biological and morphological factors controlling carbon and oxygen stable isotope fractionation in foraminifera (δ13C and δ18O) and uses these findings to address two major questions of paleoclimate—the effect of warm climates on organic carbon cycling and the strength of polar amplification through geologic time. Using a chemical model of the foraminifera’s diffusive boundary layer, it is shown that metabolism and the physical arrangement of algal symbionts on the spines and rhizopodia of planktonic foraminifera can significantly affect the δ13C signal recorded in their shells. This finding implies that vertical gradients of δ13CDIC in the Eocene were …

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Strategic Stability In The Third Nuclear Age, David Minchin Allison Apr 2022

Strategic Stability In The Third Nuclear Age, David Minchin Allison

Yale Graduate School of Arts and Sciences Dissertations

The arrival of a third nuclear age—characterized by emerging technologies and multipolarity—threatens to upend global order. For decades, scholars have taken comfort in the perceived effectiveness of extended deterrence and taboo talk by nuclear elites. But how might new vulnerabilities and incentives for use affect nuclear prospects? Using survey experiments based on realistic conflict scenarios, I investigate the effect of these changes on public opinion concerning nuclear use. Contrary to decades of scholarship, I find that prior claims matter little and support for nuclear use is highly contextual. Despite extended deterrent commitments, the U.S. public is broadly unwilling to support …

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Identification And Characterization Of Epigenetic Regulators Of Breast Cancer Metastasis, Jocelyn Fang-Yi Chen Apr 2022

Identification And Characterization Of Epigenetic Regulators Of Breast Cancer Metastasis, Jocelyn Fang-Yi Chen

Yale Graduate School of Arts and Sciences Dissertations

Cancer metastasis remains a major clinical challenge for cancer treatment. It is therefore crucial to understand how cancer cells establish and maintain their metastatic traits. Emerging evidence suggests that key steps of metastasis are controlled by reversible epigenetic mechanisms, which can be targeted to prevent and treat the metastatic disease. Although a variety of epigenetic mechanisms were identified to regulate cancer metastasis, including the well-studied DNA methylation and histone modifications, there are very few epigenetic drugs for cancer treatment and currently none of them was approved specifically for metastasis. Thus, we aim to uncover novel epigenetic regulators and identify the …

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The Differential Effects Of The 13f Disclosure Rule On Institutional Investors, David Kwon Apr 2022

The Differential Effects Of The 13f Disclosure Rule On Institutional Investors, David Kwon

Yale Graduate School of Arts and Sciences Dissertations

The 13f disclosure rule, which requires institutional investors to disclose mainly stock investments, has garnered significant attention in recent years. Some believe that copycatting activities from outside investors can harm disclosing investors’ returns, while others argue that copycatting is non-existent due to the 13f reporting delay, and that even if copycatting did exist, it would benefit disclosing investors’ returns. Do copycats harm institutions’ returns? First, I find that due to the narrow definition of the 13f rule, mainly stock investors (who comprise about 15% of institutional assets) must disclose on 13fs and so mainly stock investors are exposed to potential …

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‘Hideous Progeny’: The Role Of Monsters And Hybrids In Latin Metapoetry, Treasa Mae Bell Apr 2022

‘Hideous Progeny’: The Role Of Monsters And Hybrids In Latin Metapoetry, Treasa Mae Bell

Yale Graduate School of Arts and Sciences Dissertations

This dissertation explores the role of the monster and the hybrid in Latin poetry of the Augustan period. It asserts that these creatures symbolize the embodied literary work through close parallels between their bodies and the body of the texts in which they appear. The opening two chapters (Part I) tie monsters to ancient literary critical disputes. The first examines the connection between monstrous forms and critical terminology. The second chapter, through case studies on the recusatio and many-mouth motif, considers the relationship between the monster’s voice and the political voice of the text. Part II of the dissertation is …

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"No Angels": The Politics Of U.S. Information Interventions In Cold War Elections, Torey Mcmurdo Apr 2022

"No Angels": The Politics Of U.S. Information Interventions In Cold War Elections, Torey Mcmurdo

Yale Graduate School of Arts and Sciences Dissertations

Russia’s cyber-enabled intervention in the 2016 U.S. presidential election raised important questions about what advanced information intervention techniques might mean for future state behavior – including America’s own. The 2016 interference illuminated not only the speed and pervasiveness with which information interventions could be employed, but also their agility in targeting different platforms and spreading diverse – and even conflicting – messages. Acknowledging that relevant political context for today’s operating environment predates 2016, my dissertation integrates three related questions using the Cold War as a temporal boundary. First, why do states intervene in the domestic affairs of other states? Second, …

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Engineering Functional Distal Lung Epithelium, Katherine Leiby Apr 2022

Engineering Functional Distal Lung Epithelium, Katherine Leiby

Yale Graduate School of Arts and Sciences Dissertations

The potential for lung tissue engineering to generate lung tissue capable of gas exchange ultimately rests upon the ability to reconstitute a functional barrier between the air and blood spaces in the engineered lung alveolus. The success of this endeavor will rely in large part on the recapitulation of an alveolar epithelium, comprising alveolar epithelial type 1 cells (AEC1s) and type 2 cells (AEC2s), which provides a surface for gas diffusion, actively maintains critical features of blood-gas barrier function, and comprises resident AEC2 stem cells for ongoing maintenance and repair of the distal lung. Yet, since the beginning of this …

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Molecular Mechanisms Of Atg-9 Localization And Function In Neurons, Sisi Yang Apr 2022

Molecular Mechanisms Of Atg-9 Localization And Function In Neurons, Sisi Yang

Yale Graduate School of Arts and Sciences Dissertations

Autophagy is a cellular degradation pathway essential for neuronal health andfunction. Autophagosome biogenesis occurs at synapses, is locally regulated and increases in response to neuronal activity. The mechanisms that couple autophagosome biogenesis to synaptic activity remain unknown. In my thesis work, I determine that trafficking of ATG-9, the only transmembraneprotein in the core autophagy pathway, links the synaptic vesicle cycle with autophagy. ATG-9-positive vesicles in C. elegans are generated from the trans-Golgi network via AP- 3-dependent budding and delivered to presynaptic sites. At presynaptic sites, ATG-9 undergoes exo-endocytosis in an activity-dependent manner. Mutations that disrupt endocytosis, including a lesion in …

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Ion Transport In Membranes With Sub-Nanometer Pores: Material Design And Selectivity Mechanisms, Xuechen Zhou Apr 2022

Ion Transport In Membranes With Sub-Nanometer Pores: Material Design And Selectivity Mechanisms, Xuechen Zhou

Yale Graduate School of Arts and Sciences Dissertations

As of 2017, over 800 million people around the world still lacked the access to safe drinking water. With over 97% of the earth’s water stored in the ocean, reverse osmosis (RO) seawater desalination has been proposed as a promising solution to boost the water supply and alleviate the water shortage. Polyamide (PA) thin-film composite (TFC) membranes are the state-of-the-art membranes for RO separation and a typical PA TFC membrane can reject over 99% of the sodium chloride (NaCl) in the feed stream. Despite their exceptional water-salt separation capability, current PA membranes have two major limitations: 1) they are highly …

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Learning About Safety: Conditioned Inhibition As A Novel Approach To Fear Reduction Targeting The Developing Brain, Paola Odriozola Apr 2022

Learning About Safety: Conditioned Inhibition As A Novel Approach To Fear Reduction Targeting The Developing Brain, Paola Odriozola

Yale Graduate School of Arts and Sciences Dissertations

Fear serves an adaptive function by allowing an organism to predict potentially aversive events from environmental cues, increase vigilance, and avoid potential danger. However, fear responses can become maladaptive when they are excessive or prevent an individual from engaging in goal-directed activities (Rothbaum & Davis, 2003). Anxiety disorders, which are characterized by this failure to regulate fear, are the most common psychiatric illnesses, affecting up to one-third of the population (Kessler et al., 2005). Adolescence is a peak time for the onset of mental illness, with anxiety being the most common disorders (Beesdo et al., 2009; Merikangas & Swanson, 2010), …

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The Impacts Of Unconventional Oil And Gas Development On Drinking Water And Children’S Health, Cassandra J. Clark Apr 2022

The Impacts Of Unconventional Oil And Gas Development On Drinking Water And Children’S Health, Cassandra J. Clark

Yale Graduate School of Arts and Sciences Dissertations

Unconventional oil and gas development (UOGD) combines horizontal drilling with hydraulic fracturing (the pressurized injection of millions of gallons of water and chemicals) to extract fossil fuels such as natural gas from deep rock deposits. UOGD has led to community concern over environmental hazards, such as water contamination, and health hazards, such as cancer. This dissertation examines the impacts of UOGD on communities in the Appalachian Basin from the perspective of three disciplines: exposure science, environmental justice, and epidemiology (background and overall aims summarized in Chapter 1). Chapter 2 investigates whether UOG exposure through household groundwater is captured by spatial …

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Associations Between Adherence To Lifestyle Behaviors And Obesity-Related Cancer Risk And Outcomes Among Black/African American And Hispanic/Latino Adults, Margaret S. Pichardo Apr 2022

Associations Between Adherence To Lifestyle Behaviors And Obesity-Related Cancer Risk And Outcomes Among Black/African American And Hispanic/Latino Adults, Margaret S. Pichardo

Yale Graduate School of Arts and Sciences Dissertations

BackgroundObesity is a chronic disease that has been established in the etiology of at least 14 cancers. Rates of many of these obesity-related cancers (ORC) have been increasing among Black/African American and Hispanic/Latino populations. Following the American Cancer Association’s (ACS) nutrition and physical activity cancer prevention guidelines has been associated with a 10-61% reduction in overall cancer incidence and mortality. However, just 5 to 14% of the general population and cancer survivors follow these guidelines. Limited research suggests that adherence with the cancer prevention guidelines results in a greater reduction in cancer risk and mortality for Black/African American and Hispanic/Latino …

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Tumor-Intrinsic Mechanisms Of Immune Evasion And Metabolic Reprogramming For T Cell Immunotherapy, Paul Renauer Apr 2022

Tumor-Intrinsic Mechanisms Of Immune Evasion And Metabolic Reprogramming For T Cell Immunotherapy, Paul Renauer

Yale Graduate School of Arts and Sciences Dissertations

Immune evasion is a critical step of cancer progression that can occur through tumor-intrinsic and extrinsic mechanisms. Tumor-intrinsic mechanisms such as immune checkpoints have been promising targets for immunotherapy; However, there remain fundamental gaps in our understanding of immune evasion, as well as unexplored strategies to improve current immunotherapies. We hypothesized that we can identify novel genetic factors that mediate immune escape by leveraging in vivo tumorigenesis screens in hosts with different levels of immunocompetence. Specifically, parallel high-throughput genetic knock-out screens were performed in immortalized hepatocytes that are able to generate tumors in immunocompromised but not wild-type mice to determine …

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Destruction, Reconstruction, & Migration In The Wake Of Wildfires, Kathryn Mcconnell Apr 2022

Destruction, Reconstruction, & Migration In The Wake Of Wildfires, Kathryn Mcconnell

Yale Graduate School of Arts and Sciences Dissertations

The scale of wildfire destruction has grown rapidly in recent years, destroying nearly 25,000 buildings in the U.S. during 2018 alone. Recently, scientists have developed nationwide wildfire event data, making it possible to model wildfire effects on human migration. In Chapter 1, quarterly data on residential mobility from the Federal Reserve Bank of New York/Equifax Consumer Credit Panel are paired with building destruction counts from the U.S. National Incident Management System/Incident Command System database of wildfire events to evaluate the effects of wildfire destruction on migration probabilities in the U.S. between 1999 and 2018. Findings indicate that only the most …

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