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Yale Scientific Magazine: Volume 59, Number 2 Jan 1985

Yale Scientific Magazine: Volume 59, Number 2

Yale Scientific Magazine

No abstract provided.


Small Cell Cancer Of The Lung : An Initial Evaluation Of The Yale Treatment Protocol, David Jonathan Birnkrant Jan 1985

Small Cell Cancer Of The Lung : An Initial Evaluation Of The Yale Treatment Protocol, David Jonathan Birnkrant

Yale Medicine Thesis Digital Library

No abstract provided.


The Type Specimens Of Tapivarus Validus And Tapivarus Rarus (Mammalia, Perissodactyla), With A Review Of The Genus, And A New Report Of Miotapirus (Miotapirus Marslandensis Schoch And Prins, New Species) From Nebraska, Robert Milton Schoch Dec 1984

The Type Specimens Of Tapivarus Validus And Tapivarus Rarus (Mammalia, Perissodactyla), With A Review Of The Genus, And A New Report Of Miotapirus (Miotapirus Marslandensis Schoch And Prins, New Species) From Nebraska, Robert Milton Schoch

Postilla

Tapiravus Marsh, 1877, is a tapirid genus known from the middle Miocene to early Pliocene of New Jersey, Maryland, Florida and Nebraska. Three species have been referred to Tapiravus: T. validus (Marsh, 1871: the type species), T. rarus Marsh, 1877, and T. polkensis Olsen, 1960. In this paper the type specimens of T. validus and T. rarus are thoroughly described and illustrated for the first time. Additionally, all known specimens referable to the genus Tapiravus are listed. I conclude that Tapiravus is a valid genus composed of two recognizable species: T. validus and T. polkensis. The holotype and only known …


Notes On The Type Specimens Pteranodon And Nyctosaurus (Pterosauria, Pteranodontidae) In The Yale Peabody Museum Collections, Robert Milton Schoch Dec 1984

Notes On The Type Specimens Pteranodon And Nyctosaurus (Pterosauria, Pteranodontidae) In The Yale Peabody Museum Collections, Robert Milton Schoch

Postilla

The type specimens of the nine named species of the Cretaceous pterodactyls Pteranodon and Nyctosaurus housed in the Peabody Museum of Natural History, Yale University, Vertebrate Paleontology Collections are documented and lectotypes for Pteranodon occidentalis, Pteranodon ingens and Pteranodon comptus are herein designated. A thorough revision of Pteranodon and Nyctosaurus should consider all eighteen named species which have been referred to these genera and should also include specimens currently dispersed throughout numerous museums on several continents. However, preliminary to such a revision, based on the Peabody Museum Collections the following systematic suggestions can be made: 1) Pteranodon longiceps and P. …


Purification, Characterization And Distribution Of A Calmodulin-Dependent Protein Kinase From Rat Brain Cytosol, James Richard Goldenring Dec 1984

Purification, Characterization And Distribution Of A Calmodulin-Dependent Protein Kinase From Rat Brain Cytosol, James Richard Goldenring

Yale Medicine Thesis Digital Library

Tubulin is a major endogenous substrate for Ca('2+)- calmodulin-dependent kinase activity in rat brain cytosol. This dissertation details the purification and characterization of a calmodulin-dependent tubulin kinase from rat brain cytosol. The kinase, purified from chelated brain cytosol by sequential chromatography on phosphocellulose, calmodulin-affinity resin, and Fractogel TSK-55F, contains two calmodulin-binding, autophosphorylating subunits of 52,000 and 63,000 daltons, designated rho and sigma, respectively. The kinase holoenzyme complex has a native molecular weight of 600,000 daltons. Both kinase subunits demonstrate isoelectric points near neutrality. The kinase phosphorylated microtubule-associated protein 2, alpha tubulin and beta tubulin as major substrates. Calmodulin-dependent phosphorylation of …


Externalities, Heterogeneity And The Optimal Distribution Of Public Programs: Child Health Family Planning Interventions, Mark Rosenzweig, Kenneth I. Wolpin Dec 1984

Externalities, Heterogeneity And The Optimal Distribution Of Public Programs: Child Health Family Planning Interventions, Mark Rosenzweig, Kenneth I. Wolpin

Discussion Papers

No abstract provided.


Migration Selectivity And The Effects Of Government Programs, Mark Rosenzweig, Kenneth I. Wolpin Dec 1984

Migration Selectivity And The Effects Of Government Programs, Mark Rosenzweig, Kenneth I. Wolpin

Discussion Papers

No abstract provided.


The Incidence Of Market-Stabilizing Price Support Schemes, Brian D. Wright, Jeffery Williams Dec 1984

The Incidence Of Market-Stabilizing Price Support Schemes, Brian D. Wright, Jeffery Williams

Discussion Papers

No abstract provided.


A Note On The Unbiasedness Of Feasible Gls, Quasi-Maximum Likelihood, Robust Adaptive, And Spectral Estimators Of The Linear Model, Donald W.K. Andrews Dec 1984

A Note On The Unbiasedness Of Feasible Gls, Quasi-Maximum Likelihood, Robust Adaptive, And Spectral Estimators Of The Linear Model, Donald W.K. Andrews

Cowles Foundation Discussion Papers

This note presents a set of conditions on the defining functions of regression parameter estimators of the linear model. These conditions guarantee that the estimators are symmetrically distributed about the true parameter value, and hence are median unbiased, provided the conditional distribution of the vector of errors is symmetric given the matrix of regressors. The symmetry result holds even if the regression parameters are subject to linear restrictions. If the estimators posses one or more moments, then the symmetry result also implies mean unbiasedness. Similar conditions are provided that establish the property of origin (or shift) equivariance for the estimators. …


On A General Existence Theorem For Marginal Cost Pricing Equilibria, Donald J. Brown, Geoffrey M. Heal, M. Ali Khan, Rajiv Vohra Dec 1984

On A General Existence Theorem For Marginal Cost Pricing Equilibria, Donald J. Brown, Geoffrey M. Heal, M. Ali Khan, Rajiv Vohra

Cowles Foundation Discussion Papers

We report a generalization of recent results on the existence of marginal cost pricing equilibria (MCPE) in economies with an increasing returns to scale industry. Our result makes no ad hoc assumptions which force the equilibrium to be on the efficiency frontier of the aggregate production possibility set. We also present an additional condition under which our MCPE are productivity efficient in the aggregate.


Testing The Random Walk Hypothesis: Power Versus Frequency Of Observation, Robert J. Shiller, Pierre Perron Dec 1984

Testing The Random Walk Hypothesis: Power Versus Frequency Of Observation, Robert J. Shiller, Pierre Perron

Cowles Foundation Discussion Papers

Power functions of tests of the random walk hypothesis versus stationary first order autoregressive alternatives are tabulated for samples of fixed span but various frequencies of observation. For a t -test and normalized test, power is found to depend, for a substantial range of parameter values, more on the span of the data in time than on the number of observations. For a runs test, power rapidly declines as the number of observations is increased beyond a certain point.


A Note On The Unbiasedness Of Feasible Gls, Quasi-Maximum Likelihood, Robust Adaptive, And Spectral Estimators Of The Linear Model, Donald W.K. Andrews Dec 1984

A Note On The Unbiasedness Of Feasible Gls, Quasi-Maximum Likelihood, Robust Adaptive, And Spectral Estimators Of The Linear Model, Donald W.K. Andrews

Cowles Foundation Discussion Papers

This note presents a set of conditions on the defining functions of regression parameter estimators of the linear model. These conditions guarantee that the estimators are symmetrically distributed about the true parameter value, and hence are median unbiased, provided the conditional distribution of the vector of errors is symmetric given the matrix of regressors. The symmetry result holds even if the regression parameters are subject to linear restrictions. If the estimators posses one or more moments, then the symmetry result also implies mean unbiasedness. Similar conditions are provided that establish the property of origin (or shift) equivariance for the estimators. …


Yale Nurse, Yale School Of Nursing Dec 1984

Yale Nurse, Yale School Of Nursing

Yale School of Nursing Alumni Newsletters and Magazines

No abstract provided.


Mitomycin C And Porfiromycin: Studies On Bioactivation And Cytotoxicity In Cultured Cell Lines, Paula Marie Fracasso Dec 1984

Mitomycin C And Porfiromycin: Studies On Bioactivation And Cytotoxicity In Cultured Cell Lines, Paula Marie Fracasso

Yale Medicine Thesis Digital Library

Solid neoplasms are known to contain deficient or poorly functional vascular beds and as a result populations of cells in these solid tumors may contain hypoxic or poorly oxygenated tumor cells. These hypoxic tumor cells may form a therapeutically resistant cell population within the tumor difficult to eradicate by ionizing radiation and most existing chemotherapeutic agents. As a consequence, this dissertation has investigated the mechanism of bioactivation and cytotoxicity of mitomycin C and porfiromycin, structurally similar antibiotics which are selectively cytotoxic to hypoxic cells.Mitomycin C was preferentially cytotoxic to hypoxic EMT6 and V79 cells in culture, but was not selectively …


Games With Perceptive Commanders But Less Perceptive Subordinates, Martin Shubik Dec 1984

Games With Perceptive Commanders But Less Perceptive Subordinates, Martin Shubik

Cowles Foundation Discussion Papers

We introduce a model of the 2 x 2 games played by agents or subordinates of the players. We assume that each agent or subordinates of the players. We assume that each agent is not as perceptive as his commander in that he can make only two distinctions among the four outcomes whose value can be distinguished by the commanders.


Net Worth Certificate Assistance Programs: Their Design, Major Differences, And Early Implementation, Us Government Accountability Office Nov 1984

Net Worth Certificate Assistance Programs: Their Design, Major Differences, And Early Implementation, Us Government Accountability Office

Documents

No abstract provided.


Managerial Incentives And Capital Management, Bengt Holmstrom, Joan E. Ricart-Costa Nov 1984

Managerial Incentives And Capital Management, Bengt Holmstrom, Joan E. Ricart-Costa

Cowles Foundation Discussion Papers

In Holmstrom (1982) an example is given, which shows that a manager’s concern for the value of his human capital will lead to a natural incongruity in risk-preferences between himself and the owners, even when no effort considerations are involved. In this paper we present a formal model of this channel of incongruity based on learning about managerial talent. We also explore the nature of an optimal incentive contract in the case where the manager may withhold but not misrepresent information about investment returns. The optimal contract is an option on the manager’s human capital value with a possible bonus …


The Dynamic Demand For Capital And Labor, Matthew D. Shapiro Nov 1984

The Dynamic Demand For Capital And Labor, Matthew D. Shapiro

Cowles Foundation Discussion Papers

A model of the dynamically interrelated demand for capital and labor is specified and estimated. The estimates are of the first-order conditions of the firm’s problem rather than of the closed-form decision rules. This use of the first-order conditions allows a random rate of return and a flexible specification of the technology. The estimates do not imply the very slow rates of adjustment displayed in other, related estimates of the demand for capital. Because adjustment is estimated to be rapid, there is, contrary to the standard view, scope for factor-prices to affect investment at relatively high frequencies.


A Note On Enough Money In A Strategic Market Game With Complete Or Fewer Markets, Martin Shubik Nov 1984

A Note On Enough Money In A Strategic Market Game With Complete Or Fewer Markets, Martin Shubik

Cowles Foundation Discussion Papers

This paper discusses the notion of “enough money” in strategic market games. In an economy with one money, m-1 markets and no credit, in order to be able to achieve efficient trade there must be “enough money” held by all traders. In essence “enough money” means that the noncooperative equilibrium solutions to a strategic market game is interior, in other words it is not considered by lack of liquidity. For simplicity two specific market mechanisms are described to illustrate the relationship between market structure and liquidity.


The Exact Distribution Of The Wald Statistic: The Non-Central Case, Peter C.B. Phillips, Sam Ouliaris Nov 1984

The Exact Distribution Of The Wald Statistic: The Non-Central Case, Peter C.B. Phillips, Sam Ouliaris

Cowles Foundation Discussion Papers

This paper extends earlier results, which were reported in [7], to include non null distributions. As in [7], attention is concentrated on the Wald statistic for testing general linear restrictions on the coefficients in the multivariate linear model. The results of the present paper encompass the null distributions derived in [7] and generalize all previously known results for such statistics as the standard regression test and Hotelling’s T 2 test.


Fnma Charter On Hud And Goals, Federal National Mortgage Association (Fannie Mae) Oct 1984

Fnma Charter On Hud And Goals, Federal National Mortgage Association (Fannie Mae)

Documents

No abstract provided.


Expansionary Government Policy In An Economy With Commodity And Labor, Russell Cooper Oct 1984

Expansionary Government Policy In An Economy With Commodity And Labor, Russell Cooper

Cowles Foundation Discussion Papers

This paper considers a model in which all exchange is mediated by contracts. The analysis explores the indexation of labor and commodities contracts to observable variations in government spending financed by money creation. In one of the many equilibria, prices and nominal wages are shown to be independent of current money shocks. Except in the extreme equilibrium exhibiting full indexation, policy shocks will generate correlated movements in output and employment over time. The analysis thus suggests an inverse relationship between indexation of contracts and persistence of policy effects.


Neighborhood Systems For Production Sets With Indivisibilities, Herbert E. Scarf Oct 1984

Neighborhood Systems For Production Sets With Indivisibilities, Herbert E. Scarf

Cowles Foundation Discussion Papers

No abstract provided.


A Mean-Variance Approach To Fundamental Valuations, James Tobin Oct 1984

A Mean-Variance Approach To Fundamental Valuations, James Tobin

Cowles Foundation Discussion Papers

No abstract provided.


Strategic Market Games: A Dynamic Programming Application To Money, Banking And Insurance, Martin Shubik Oct 1984

Strategic Market Games: A Dynamic Programming Application To Money, Banking And Insurance, Martin Shubik

Cowles Foundation Discussion Papers

A series of models (kept simple in order to stress the structure of the models and the nature of the questions) are described and problems are posed pertaining to a dynamic economy with various possibilities for the issuance of fiat money, credit and insurance.


Optimal Cartel Equilibria With Imperfect Monitoring, Dilip Abreu, David G. Pearce, Ennio Stacchetti Oct 1984

Optimal Cartel Equilibria With Imperfect Monitoring, Dilip Abreu, David G. Pearce, Ennio Stacchetti

Cowles Foundation Discussion Papers

There exist optimal symmetric equilibria in the Green-Porter model [5, 8] having an elementary intertemporal structure. Such an equilibrium is described entirely by two subsets of price space and two quantities, the only production levels used by firms in any contingency. The central technique employed in the analysis is the reduction of the repeated game to a family of static games.


Yale-New Haven Special Issue : 1984 Annual Report, Yale-New Haven Hospital Sep 1984

Yale-New Haven Special Issue : 1984 Annual Report, Yale-New Haven Hospital

Yale New Haven Hospital Annual Reports

For the year 1984. Year ending September 30, 1984.


Heterogeneity, Intrafamily Distribution And Child Health, Mark Rosenzweig, Kenneth I. Wolpin Sep 1984

Heterogeneity, Intrafamily Distribution And Child Health, Mark Rosenzweig, Kenneth I. Wolpin

Discussion Papers

No abstract provided.


An Everywhere Convergent Series Representation Of The Distribution Of Hotelling's Generalized T 2^0, Peter C.B. Phillips Sep 1984

An Everywhere Convergent Series Representation Of The Distribution Of Hotelling's Generalized T 2^0, Peter C.B. Phillips

Cowles Foundation Discussion Papers

A new series representation of the exact distribution of Hotelling’s generalized T 0 2 statistic is obtained. Unlike earlier work, the series representation given here is everywhere convergent. Explicit formulae are given for both the null and the noncentral distributions. Earlier results by Constantine [1], which are convergent on the interval [0,1), are also derived quite simply from our formulae.


Testing For Serial Correlation And Unit Roots Using A Computer Function Routine Based On Era's, Peter C.B. Phillips, Peter C. Reiss Sep 1984

Testing For Serial Correlation And Unit Roots Using A Computer Function Routine Based On Era's, Peter C.B. Phillips, Peter C. Reiss

Cowles Foundation Discussion Papers

This paper initiates a research program to provide computer function routines that can be used to deliver critical values or significance levels for statistical tests. These routines are easily integrated into existing econometric software and can be made available on a user call basis. The mathematical formulae underlying these approximants belong to the family of extended rational approximants (ERA’s) introduced in [15]. The first part of this paper extends the algebraic theory of ERA’s to distribution function approximation. Composite functional approximants are also developed to treat the parameter multidimensionally that is common in practical application. The second part of the …