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The Satellite And The Territory: Essays On Remote Sensing And The Economics Of Sustainable Development, Matthew Gordon Oct 2023

The Satellite And The Territory: Essays On Remote Sensing And The Economics Of Sustainable Development, Matthew Gordon

Yale Graduate School of Arts and Sciences Dissertations

The increasing availability of satellite data is creating unprecedented opportunities to study sustainable development processes at both a global scale and fine temporal and spatial resolution. Economists and environmental researchers are using satellite data products to measure land-use change, economic growth, household vulnerability, air pollution, and more. When these data products are used in research or policy-making uncritically, however, the conclusions that follow can be inappropriate. This dissertation examines the potential opportunities and the shortcomings of three different uses of satellite data to inform sustainable development policy -- targeting policy, causal inference, and measurement. The first chapter studies the question …

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Integrating Genetics And Brain Connectivity: Overcoming Statistical Challenges To Uncover The Neural Basis Of Psychiatric And Behavioral Disorders, Wei Dai Oct 2023

Integrating Genetics And Brain Connectivity: Overcoming Statistical Challenges To Uncover The Neural Basis Of Psychiatric And Behavioral Disorders, Wei Dai

Yale Graduate School of Arts and Sciences Dissertations

The exploration of the associations between genetic variants or single nucleotide polymor- phisms (SNPs), brain connectivity, and mental disorders is crucial for comprehending the biological origins of psychiatric and behavioral conditions. Biomedical technologies, such as magnetic resonance imaging (MRI) and next-generation sequencing (NGS), can help elu- cidate the underlying biological processes. Resting state functional MRI (rsfMRI) studies have demonstrated altered functional connectivity in numerous psychiatric and behavioral disorders, which is moderately heritable and can be linked to genetic variants. Diffusion tensor imaging (DTI) can be employed to investigate the structural foundation of func- tional networks. However, challenges remain in analyzing …

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On The Evolution Of Crassulacean Acid Metabolism: Diversity, Anatomy, And Genetic Components, Ian Spencer Gilman Oct 2023

On The Evolution Of Crassulacean Acid Metabolism: Diversity, Anatomy, And Genetic Components, Ian Spencer Gilman

Yale Graduate School of Arts and Sciences Dissertations

Crassulacean acid metabolism (CAM) is an adaption to water- and CO2-limitation that has evolved independently in dozens of vascular plant lineages. The study of CAM began with 18th and 19th botanists, who noted curious changes in plant sap acidity and dark-period gas exchange in succulent plants, and continues into the genomics age with goals of engineering CAM into crops in light of global climate change. The major enzymes, metabolites, and day-night rhythms of CAM have long been established, but many fundamental questions remain, and modern molecular and computational tools allow us to ask new questions about the evolution and genetic …

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Deciphering Immune Interactions In The Tumor Microenvironment, Orr-El Weizman Oct 2023

Deciphering Immune Interactions In The Tumor Microenvironment, Orr-El Weizman

Yale Graduate School of Arts and Sciences Dissertations

Deciphering the Tumor Immune Interactome Cancerous transformations are initiated in normal healthy cells by oncogenic hits. Subsequent acquisition of somatic mutations over time results in the transformation of aberrant cells to cancerous outgrowth to eventual metastatic dissemination. Since the multistep process of oncogenesis does not exist in a vacuum, as these cells arise within the context of a tissue, how does host defenses interact with aberrant transformed cancerous cells? As early as 1909, Paul Ehrlich offered the first hypothesis of immune interaction with tumor cells, arguing that the immune cells can recognize and protect against cancer cells. Further developed by …

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Identifying Cellular And Molecular Mechanisms Contributing Towards Neuronal Vulnerability In Spinocerebellar Ataxia Type 1, Kimberly Petra Luttik Oct 2023

Identifying Cellular And Molecular Mechanisms Contributing Towards Neuronal Vulnerability In Spinocerebellar Ataxia Type 1, Kimberly Petra Luttik

Yale Graduate School of Arts and Sciences Dissertations

Neurodegenerative disorders are highly complex, progressive disorders often involving interactions of multiple cell types, disease-causing genes and pathways, and brain regions. For the majority of neurodegenerative disorders, no effective therapeutics are currently available to slow disease onset or progression, and the mechanisms underlying the degeneration of specific cellular populations remain largely unknown. Here, we use spinocerebellar ataxia type 1 (SCA1) as a model to investigate the impact of the disease-causing gene, ATAXIN-1 (ATXN1), in diverse cell types and brain regions. We identify region-specific differences in disease signatures, and investigate the mechanistic contribution of glia, specifically astrocytes, towards SCA1 pathology and …

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Uncovering A Novel Role For Lsr2 In Mycobacterial Mutagenesis And Deciphering The Determinants Of Lsr2 Transcriptional Regulation, Wei Lynn Ng Oct 2023

Uncovering A Novel Role For Lsr2 In Mycobacterial Mutagenesis And Deciphering The Determinants Of Lsr2 Transcriptional Regulation, Wei Lynn Ng

Yale Graduate School of Arts and Sciences Dissertations

Chromosomal mutations drive the evolution of antibiotic resistance in M. tuberculosis. Unlike many other pathogens, M. tuberculosis has no demonstrated ability for horizontal gene transfer, a major mechanism for developing antibiotic resistance. The error-prone translesion polymerase complex DnaE2/ImuA’/ImuB is one of the primary mediators of mutagenesis and antibiotic resistance in vitro and possibly in vivo. To catalyze error-prone DNA synthesis, DnaE2/ImuA’/ImuB must be able to access the DNA by binding the β2-sliding clamp of the replisome, and potentially compete with other polymerases, including the high-fidelity replicative polymerase DnaE1. However, the mechanisms that govern polymerase switching are not well understood, especially …

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Towards Practical Electrocatalysis For Industrial Wastewater Treatment, David Kim Oct 2023

Towards Practical Electrocatalysis For Industrial Wastewater Treatment, David Kim

Yale Graduate School of Arts and Sciences Dissertations

Electrocatalytic water treatment has emerged into the limelight of academic interest, yet their long-term viability remains largely in the dark. Despite major progress in materials and systems development, little is known regarding their performance under real wastewater matrices, which contain a multitude of impurities at everchanging concentrations. In this dissertation, we will present a thorough framework on how to realize the solutions of these key challenges and move towards practical implementation. This work will first demonstrate the formulation of a benchmarking protocol to systematically assess the impacts of wastewater on catalytic performance. In particular, H2O2 electrocatalytic synthesis is highlighted as …

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Learning Latent Representations For Biological Molecules, Tianxiao Li Oct 2023

Learning Latent Representations For Biological Molecules, Tianxiao Li

Yale Graduate School of Arts and Sciences Dissertations

Recent progresses in machine learning have achieved phenomenal successes in the prediction of properties of biological molecules from large biological data. However, how much the models really “understand” the nature of the data remains an important question. Representation learning aims at extracting information-rich, low dimensional vector representations from complex high dimensional data. Such representations not only facilitate visualization and interpretation of the data, but also flexibly and efficiently generalized to other downstream tasks without having to re-learn universal patterns in every application. Furthermore, in generative modelling, the latent representations can be directly manipulated to direct the generation towards desired properties. …

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Seismic And Kinematic Studies Of Subduction Zones Along The Western Margins Of North And South America, Neta Bar Oct 2023

Seismic And Kinematic Studies Of Subduction Zones Along The Western Margins Of North And South America, Neta Bar

Yale Graduate School of Arts and Sciences Dissertations

Subduction zones are a fundamental part of plate tectonics yet changes in the morphology and behavior of subducting slabs with time and their relations to surface expression and deformation in the upper plate remain uncertain. The west margins of North and South America have been shaped by long periods of subduction, providing a valuable opportunity to explore the long-term evolution of subduction zones. This thesis presents three studies on subduction zones along the western margins of North and South America. The first study focuses on the Central Andes above the subducting Nazca plate in northern Bolivia and southern Peru. The …

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Telescope Pointing For The Simons Observatory: Data Acquisition & Control Software, Calibration, And Modeling, Lauren Joy Saunders Oct 2023

Telescope Pointing For The Simons Observatory: Data Acquisition & Control Software, Calibration, And Modeling, Lauren Joy Saunders

Yale Graduate School of Arts and Sciences Dissertations

The Simons Observatory (SO) is a ground-based cosmic microwave background (CMB) survey experiment located in the Atacama Desert in Chile, at an elevation of 5200 m. It is made up of one 6 m Large Aperture Telescope and three 0.5 m Small Aperture Telescopes, and will study the temperature and polarization anisotropies of the CMB. SO will probe the CMB at the smallest angular scales achieved thus far, and with the highest polarization sensitivity, in search of definitive evidence for inflation in the early universe, a glimpse at the dark matter candidates that may have been abundant in the early …

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Disruption Of Trio Gef Function And Regulation In Neurodevelopmental Disorders, Ellen Elizabeth Corcoran Oct 2023

Disruption Of Trio Gef Function And Regulation In Neurodevelopmental Disorders, Ellen Elizabeth Corcoran

Yale Graduate School of Arts and Sciences Dissertations

There is a critical need to elucidate the biochemical events that control dendrite and synapse function to develop better targeted therapeutic strategies for neurodevelopmental disorders. Functionally damaging mutations in TRIO are enriched in individuals with neurodevelopmental disorders. TRIO encodes a synaptic regulatory protein with three catalytic domains (Hence the name, TRIO) - two guanine nucleotide exchange factor domains, GEF1 (Rac1 and RhoG) and GEF2 (RhoA), and a putative kinase domain. Broadly speaking, Trio serves as a signaling hub to integrate signals from cell surface receptors and coordinate cytoskeletal rearrangements by activating small GTPases. However, the mechanistic details of how Trio …

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Improving Genetic Diagnostics And Developing Gene Therapies In Rare Muscle Diseases, Kaiyue Ma Oct 2023

Improving Genetic Diagnostics And Developing Gene Therapies In Rare Muscle Diseases, Kaiyue Ma

Yale Graduate School of Arts and Sciences Dissertations

The journey towards finding a cure for rare disease patients is hindered by two significant obstacles: the challenge of obtaining a definitive diagnosis and the difficulty in accessing effective treatment. This dissertation research aims to address both issues in rare muscle diseases. Firstly, a highly adaptable workflow called Saturation Mutagenesis-Reinforced Functional assays (SMuRF) was developed to enhance variant interpretation and aid in clinical decision-making. To validate its utility, SMuRF was applied to a group of rare diseases called dystroglycanopathies, which are caused by mutations in enzymes involved in alpha-dystroglycan glycosylation, including FKRP and LARGE1. Over 99.9% of all possible single …

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Random Matrix Perturbation: Entry-Wise Analysis, Abhinav Bhardwaj Oct 2023

Random Matrix Perturbation: Entry-Wise Analysis, Abhinav Bhardwaj

Yale Graduate School of Arts and Sciences Dissertations

Consider a symmetric, additive perturbation $E$ of a symmetric, low rank matrix $A$. Given access to the perturbed data $\tilde{A}$, an important problem in statistics and numerical analysis is to draw conclusions about the matrix $A$. Of particular importance are the eigenvectors of $A$. Classical eigenvector perturbation theory gives conditions under which the eigenvectors and eigenspaces of $A$ and $\tilde{A}$ are close in the $\ell_2$ norm. In many real-world settings, $E$ is a random matrix. I will demonstrate that the classical perturbation theory falls short when $E$ is random. Furthermore, very little is known about the $\ell_{\infty}$ perturbation of the …

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Autoregulation Mechanism Of Lim Domain Kinases, Gabriela Casanova Sepulveda Oct 2023

Autoregulation Mechanism Of Lim Domain Kinases, Gabriela Casanova Sepulveda

Yale Graduate School of Arts and Sciences Dissertations

LIM kinases 1 (LIMK1) and 2 (LIMK2) are major regulators of cytoskeletal dynamics in the cell. LIMK regulates actin dynamics by phosphorylating the actin-depolymerizing factor (ADF)/cofilin family of actin-binding proteins. Cofilin proteins bind preferentially and cooperatively to ADP-bound subunits in F-actin. This binding event changes the helical rotation of actin filaments, promoting actin filament severing. LIMKs promote actin filament stabilization by inactivating cofilin through phosphorylation of Ser3. Phosphorylation of cofilin at Ser3 deactivates cofilin severing activity by inhibition of cofilin binding to actin filaments. This cycling between actin depolymerization and polymerization impacts higher-order cellular processes, including motility, differentiation, and metastasis. …

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Nuclear Spectroscopy Of Heavy Nuclei In The Shell Model Monte Carlo Method, Sohan Vartak Oct 2023

Nuclear Spectroscopy Of Heavy Nuclei In The Shell Model Monte Carlo Method, Sohan Vartak

Yale Graduate School of Arts and Sciences Dissertations

As a strongly interacting finite-size quantum many-body system, the atomic nucleus provides a captivating arena for studying a multitude of phenomena. This thesis explores applications of the shell model Monte Carlo (SMMC) method, a powerful approach to investigate heavy nuclei ($A \sim 150$), where direct diagonalization is infeasible due to the rapid growth of the model space. The SMMC enables the use of standard Monte Carlo techniques to calculate ground state, statistical, and collective properties of nuclei. In this work, we refine a recently developed method for estimating low-lying excitation energies. This method is based on the imaginary time correlation …

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A Multidisciplinary Approach With Dogs As The Model Organism To Identify Whole-Genome Breed-Specific Genotypes Potentially Relating To Human Complex Traits, Zicheng Li Oct 2023

A Multidisciplinary Approach With Dogs As The Model Organism To Identify Whole-Genome Breed-Specific Genotypes Potentially Relating To Human Complex Traits, Zicheng Li

Yale Graduate School of Arts and Sciences Dissertations

Background: Domestic dogs (Canis lupus familiaris) share more than 300 common diseases and similar spontaneous disease development characteristics with humans, making them an excellent animal model to study human heritable diseases. Besides, dogs as a model organism also have been favored for mapping complex traits that are hard to map in humans benefiting from drastically different phenotypes and limited genetic heterogeneity across breeds as results of intensive artificial selection. In light of previous studies that profiled breed-specific traits or used genome-wide association studies (GWAS) to refine loci associated with characteristic morphological features in dogs, the field has gained tremendous genetic …

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Peripheral Immune Signatures Of Fibrotic Lung Diseases, Amy Zhao Oct 2023

Peripheral Immune Signatures Of Fibrotic Lung Diseases, Amy Zhao

Yale Graduate School of Arts and Sciences Dissertations

Fibrotic lung diseases constitute a heterogeneous group of disorders that cause scarring of the lung parenchyma, making breathing difficult for patients, and affect an estimated 300,000 people in the United States alone. These diseases may have either “intrinsic” or “extrinsic” immune etiologies. A subset of these fibrotic lung diseases, like Idiopathic Pulmonary Fibrosis (IPF; intrinsic) and Fibrotic Hypersensitivity Pneumonitis (FHP; extrinsic), can often be difficult to distinguish due to their similar symptoms, pulmonary function tests, and radiographic and histologic findings. However, their immune drivers, prognoses, and treatments are distinct; thus, accurate diagnosis of the fibrotic lung disease subtype is essential …

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The Maladaptive And Adaptive Effects Of Trust And Distrust On Externalizing Behavior, Shou-An Ariel Chang Oct 2023

The Maladaptive And Adaptive Effects Of Trust And Distrust On Externalizing Behavior, Shou-An Ariel Chang

Yale Graduate School of Arts and Sciences Dissertations

A wide range of behaviors, from hostility and defiance to more severe forms ofnorm violations, such as theft and violence, comprise the spectrum of externalizing behaviors. The psychological, physical, and social consequences associated with externalizing behaviors place a significant burden on the individual, their families, and society. Research has made substantial advances in identifying environmental-level and individual-level risk factors for externalizing behavior. However, despite work indicating that both externalizing behaviors themselves and several risk factors associated with externalizing behaviors are related to disruptions in trust and distrust, limited work has considered interactions between environmental- and individual-level risk factors and levels …

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Manipulating And Measuring States Of A Superfluid Optomechanical Resonator In The Quantum Regime, Yiqi Wang Oct 2023

Manipulating And Measuring States Of A Superfluid Optomechanical Resonator In The Quantum Regime, Yiqi Wang

Yale Graduate School of Arts and Sciences Dissertations

Quantum optomechanics describes utilizing optics to precisely manipulate and read out the motional degrees of freedom of a mechanical oscillator. If the mechanical oscillator is very weakly coupled to its environment, then the optomechanical interaction can be used to control the state of the mechanical oscillator in a quantum way. Applying these systems to advanced sensing techniques has inaugurated experiments on dark matter searches, gravitational wave detection, quantum gravitational phenomena tests, and sensing beyond the standard quantum limit. I am motivated by asking: “What is the largest and most tangible object to reveal purely quantum phenomena?” In addition, I seek …

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Investigating Stem Cell Chromatin Organization And Oncogenic Tissue Morphogenic Change Through Intravital Microscopy, Sangwon Yun Oct 2023

Investigating Stem Cell Chromatin Organization And Oncogenic Tissue Morphogenic Change Through Intravital Microscopy, Sangwon Yun

Yale Graduate School of Arts and Sciences Dissertations

Tissue architecture is predicated on actively maintained cellular equilibrium. Loss of homeostatic tissue organization is a hallmark of epithelial derived malignancy. In the following studies, we attempt to understand the principles governing cell behavior in a regenerative tissue, the skin epidermis, under homeostatic conditions and during oncogenic expression. Epidermal cells undergo continual proliferation and differentiation, navigating drastic changes in gene expression and chromatin architecture during identity transition from stem to differentiated. However, when and where genome reorganization occurs continues to be an arena of active investigation. We developed a high-throughput, quantitative pipeline that enabled us to longitudinally measure chromatin compaction …

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Relocating Urban Lives: Negotiating Urban Identities And Urban Culture Beyond The City, Nicholas Payne Kearns Oct 2023

Relocating Urban Lives: Negotiating Urban Identities And Urban Culture Beyond The City, Nicholas Payne Kearns

Yale Graduate School of Arts and Sciences Dissertations

During the mid-2010s, I had done participant-observation with Puerto Ricans in Western Massachusetts who had relocated from various cities, attempting to understand their particular experiences and the particular challenges that they had faced. I had spent time with them in a neighborhood with concentrated poverty where they would often meet up to socialize, and through conversations, I had attempted to gain a more meaningful perspective on this demographic about which not that much research has been produced. By engaging with seven men who had relocated from as far away as Salinas, Puerto Rico and Jacksonville, Florida, and more proximate urban …

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Consequences Of Childhood Maltreatment And Exposure To Community Violence: A Single-Moment And Longitudinal Trajectory Examination, Suzanne Charlotte Estrada Oct 2023

Consequences Of Childhood Maltreatment And Exposure To Community Violence: A Single-Moment And Longitudinal Trajectory Examination, Suzanne Charlotte Estrada

Yale Graduate School of Arts and Sciences Dissertations

Childhood adversity is one of the strongest predictors of long-term psychological,social, and physical negative life outcomes. Two subtypes of adversity, one perpetrated by someone in the home environment (i.e., childhood maltreatment, parental harshness) and the other perpetrated by someone in the community (i.e., exposure to community violence), are especially salient predictors of poor mental health and increased antisocial behavior. Research aimed at describing the occurrence of adversity often examines these subtypes separately. As a result, our understanding of the ways individuals experience adversity in the home and community and the long-term impact of co-occurring adversity is limited. Additionally, perhaps following …

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Informing Design Of Sustainable Sorbents For Drinking Water Treatment: Faceted Nanohematite For Oxoanion Removal, Holly Elizabeth Rudel Oct 2023

Informing Design Of Sustainable Sorbents For Drinking Water Treatment: Faceted Nanohematite For Oxoanion Removal, Holly Elizabeth Rudel

Yale Graduate School of Arts and Sciences Dissertations

Provision of safe drinking water is of global importance, as evidenced by the United Nations Sustainable Development Goals, and yet significant inequities still exist in its access. Particularly, people that are geographically and/or economically limited bear the greatest burden. Within the United States, high costs of treatment for small communities or individual households pose significant barriers to the removal of contaminants below regulatory limits, let alone to health protective concentrations. Of particular concern are inorganic oxoanions (e.g., arsenic (As) and selenium (Se)), which pose serious risks to human and environmental health and are simultaneously challenging to remove because of their …

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Who Governs Schools?: Alienation And Participatory Democracy In New Haven Public Education, Alexander Kolokotronis Oct 2023

Who Governs Schools?: Alienation And Participatory Democracy In New Haven Public Education, Alexander Kolokotronis

Yale Graduate School of Arts and Sciences Dissertations

Scholars, policymakers, and theoreticians have long debated the purpose of education and schooling. For all the articulations of what schools reproduce and what should be their purpose, political theorization rarely departs from what is endemic to schools and has long been reproduced by them: alienation. Whatever the stated or longed for purposes of schooling, these missions cannot be achieved if students, teachers, and other constituents of schools are alienated within the labor process of schooling. Thus, this dissertation asks: What form of political agency enables the redress of the entwined alienation of teachers and students in schools? What are its …

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Learning And Decision Making Across Domains, Chelsea Yi Xu Oct 2023

Learning And Decision Making Across Domains, Chelsea Yi Xu

Yale Graduate School of Arts and Sciences Dissertations

Rewards and punishments motivate human behavior and guide learning and decision-making processes. Rewarding or punishing feedback leads to updating of our expectations, or subjective values, associated with specific objects or experiences. The construction of subjective value is multi-faceted and can be influenced by various factors, including context, uncertainty, and timing. Many previous studies have predominantly focused on the domain of either rewards or punishments, leaving a significant gap in the literature. Furthermore, these studies have primarily been conducted in the realm of monetary decision making, failing to capture the diverse range of real-life decision outcomes that include diverse categories and …

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Investigating The Synaptic Plasticity Mechanisms Underlying A Learned Behavioral Preference In C. Elegans, Joon Ha Lee Oct 2023

Investigating The Synaptic Plasticity Mechanisms Underlying A Learned Behavioral Preference In C. Elegans, Joon Ha Lee

Yale Graduate School of Arts and Sciences Dissertations

A fundamental goal in neuroscience is to elucidate the cellular and molecular mechanisms that regulate learned behavioral preferences, or memories. While modulation of synaptic connections has been well-established as a component of memory formation, there remains a critical lack in understanding of how specific molecular changes that alter synaptic physiology result in learned behaviors. In this thesis, I utilize the paradigm of learned thermal preferences and the connection between a sensory neuron (AFD) and its postsynaptic partner (AIY) in Caenorhabditis elegans to bridge this gap at the single-synapse level. I first characterize the neurotransmission requirements of this synapse and find …

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Learning Data-Driven Representations For Biomolecular Analysis, Optimization, And Design, Egbert Castro Oct 2023

Learning Data-Driven Representations For Biomolecular Analysis, Optimization, And Design, Egbert Castro

Yale Graduate School of Arts and Sciences Dissertations

Recently, the study of biomolecules has undergone a shift toward high-throughput experimentation, leveraging advancements across various fields to produce datasets of unprecedented scale. Within these datasets, there are undiscovered truths that carry major implications for our understanding of biology and our ability to treat disease. However, innovative approaches are needed to distill signals from noise and enable the next generation of discoveries. Deep learning methods have excelled in their ability to learn from complex and large datasets in many domains, but their potential for biomolecular data has yet to be fully realized. To do so requires the ability to integrate …

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Tenascin-C: A Regulator Of Venous Remodeling Following Aortocaval Fistula Creation, Luis Gonzalez Oct 2023

Tenascin-C: A Regulator Of Venous Remodeling Following Aortocaval Fistula Creation, Luis Gonzalez

Yale Graduate School of Arts and Sciences Dissertations

End-stage kidney disease (ESKD) represents a growing medical problem globally with a high burden to patients. In the United States alone more than 740,000 individuals have ESKD and are primarily dependent on hemodialysis for treatment. For patients who require hemodialysis, arteriovenous fistulae (AVF) are the preferred mode of vascular access due to their superior patency rates and reduced infection rates when compared to grafts or catheters. However, the lifespan of an AVF is limited by several complications, which includes neointimal hyperplasia (NIH) and thrombosis. Loss of AVF patency at 1-year ranges ~40-50%. Successful AVF maturation is characterized by venous wall …

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Specters Of Degradation: Poverty And Uplift In Modern Political Thought, Chris Anthony Chambers Oct 2023

Specters Of Degradation: Poverty And Uplift In Modern Political Thought, Chris Anthony Chambers

Yale Graduate School of Arts and Sciences Dissertations

This dissertation traces the imprint of Adam Smith on modern political theories of poverty and uplifting the poor to provide an original account of the surprising synergies between conservative, liberal, and radical perspectives on redressing poverty. Offering the first manuscript-length study of poverty and the poor in the history of political thought since the 2000s, it examines how claims about the degradation of the poor have paradoxically animated while limiting ideas of uplift and perfectibility. I show how, by focusing on the moral condition of the poor and effects of poverty, conservatives, liberals, and radicals alike reproduced hateful stereotypes about …

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Functionalized Dna Nanostructures For Membrane Engineering, Qiancheng Xiong Oct 2023

Functionalized Dna Nanostructures For Membrane Engineering, Qiancheng Xiong

Yale Graduate School of Arts and Sciences Dissertations

DNA nanotechnology is a powerful tool for constructing precisely designed nanostructures with applications in diverse fields, including synthetic biology, nanomedicine, and biomolecular engineering. This dissertation explores the use of DNA nanotechnology in membrane engineering, focusing on developing DNA endoskeleton-supported membranes and large functionalized DNA-toxin nanopores. The first approach encountered challenges while constructing interlocked DNA nanostructures for endoskeleton-supported membranes. The negative results highlighted the need to optimize the interlocked DNA endoskeleton cage design further to ensure its practical application in templating fully exposed, continuous membranes. The second approach incorporated pneumolysins into DNA-origami channels to create large, functionalized DNA-toxin nanopores. These hybrid …

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