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(Special Section) Translating Race: Mission Hymns And The Challenge Of Christian Identity, Philip Burnett
(Special Section) Translating Race: Mission Hymns And The Challenge Of Christian Identity, Philip Burnett
Yale Journal of Music & Religion
“Ye seed of Israel’s chosen race,” “The race that long in darkness pined,” “To heal and save a race undone,” and “Sanctify a ransomed race” are a few examples of many references to “race” that exist in English-language hymnody. Throughout the nineteenth-century, hymns containing lines such as these, were exported from Britain into mission fields where translators had to find new ways to conceptualize notions of race and, in effect, created new group identities. This requires asking critical questions about the implications of what happened when ideas of race, in the Christian sense, interacted with non-religious notions of race in …
Efficacy Of Psychotherapy-Supported Mdma In The Treatment Of Complex Posttraumatic Stress Disorder, Danielle Dubois
Efficacy Of Psychotherapy-Supported Mdma In The Treatment Of Complex Posttraumatic Stress Disorder, Danielle Dubois
Yale School of Medicine Physician Associate Program Theses
Complex Posttraumatic Stress Disorder is a debilitating psychiatric disorder with no approved treatment options despite the high symptom burden and diminished quality of life. Randomized controlled trials have shown robust attenuation of posttraumatic stress disorder symptomatology using treatment with 3,4-Methylenedioxymethamphetamine (MDMA) plus psychotherapy, but individuals with complex traumatization have not been studied explicitly. Prior trials primarily utilized an inactive placebo group, undermining the interpretation of the results due to concern for unblinding of subjects. The proposed study is the first to utilize an active comparator to test a key hypothesis related to MDMA’s mechanism of action and to preserve blinding. …
Operation Summer Care: Territories Of The Stewardship-Hospitality Complex, George Papamattheakis
Operation Summer Care: Territories Of The Stewardship-Hospitality Complex, George Papamattheakis
Masters of Environmental Design Theses
Operation Summer Care studies the expanding interest that the hospitality industry takes in the biogeophysical environment. Natural surroundings have long been an essential operational precondition of tourism in the global sunbelt, but contemporary environmental anxieties increasingly motivate different strata of hosts to take a more active role in environmental management. Usually the domain of the state, biogeophysical entities and their spaces—plants and animals, sand formations, wetlands, entire ecosystems and protected areas—are measured, ordered, and managed by actors adjacent to the tourism industry. At the same time, the socio-technical mechanisms of environmental intervention and calculation are conveniently framed as practices of …
Spinal Fusion For Adult Degenerative Scoliosis: Rct Of Robot-Assisted Versus Navigation Guidance, Kyle Hanks
Spinal Fusion For Adult Degenerative Scoliosis: Rct Of Robot-Assisted Versus Navigation Guidance, Kyle Hanks
Yale School of Medicine Physician Associate Program Theses
Adult degenerative scoliosis is characterized by the side-to-side curvature of the spine due to the degeneration of facet joints and intervertebral discs. Life-limiting cases of adult degenerative scoliosis are corrected by spinal fusion, the success of which is determined by pedicle screw accuracy. Robot-assisted guidance has become more commonly used in spinal surgery to ensure pedicle screw placement. However, there is limited evidence for the role of robot-assisted guidance in the correction of adult degenerative scoliosis. Here, in this randomized controlled trial, we aim to investigate whether robot-assisted guidance can more consistently produce accurate pedicle screw placement than neuronavigation …
The Effect Of Neurologic Music Therapy On Speech Intelligibility In Children With Cerebral Palsy, Paulina Perez-Curiel
The Effect Of Neurologic Music Therapy On Speech Intelligibility In Children With Cerebral Palsy, Paulina Perez-Curiel
Yale School of Medicine Physician Associate Program Theses
Cerebral palsy is the most common motor disability in children and is caused by abnormal development of or damage to the brain. Children with cerebral palsy often have speech disorders, most commonly dysarthria, due to deficits in speech-motor control. The inability to communicate effectively can lead to needs not being met, self-isolation, and an overall decrease in self-perception and quality of life. In this randomized control trial, we will evaluate whether Neurologic Music Therapy improves word-level speech intelligibility in children with Cerebral Palsy. Fifty children will be exposed to Neurologic Music Therapy and fifty children will receive standard speech therapy. …
"The Moonlit Path": Reading Marie Howe In Early Motherhood, Alice Hodgkins Courtright
"The Moonlit Path": Reading Marie Howe In Early Motherhood, Alice Hodgkins Courtright
Yale Divinity School Theses
No abstract provided.
Auricular Acupressure On Depression And Anxiety In Mothers With Peripartum Depression, Jane Chan,
Auricular Acupressure On Depression And Anxiety In Mothers With Peripartum Depression, Jane Chan,
Yale School of Medicine Physician Associate Program Theses
Peripartum depression is a prevalent mental health disorder characterized by clinically significant depressive symptoms that can markedly impair maternal functioning, mother-infant bonding, and infant development. Current treatments for peripartum depression include pharmacotherapy and psychotherapy, but cost, time investment, and potential adverse effects limit their effectiveness. Auricular acupressure has been shown to improve a variety of conditions, however, there is a lack of application in peripartum depression. In this study, we propose to determine whether magnetic bead auricular acupressure reduces symptoms in mothers with peripartum depression. Using a randomized controlled trial, we will assign patients to either acupressure or sham acupressure …
The View From Somewhere: Essays On Philosophy, Positionality And Power, Moya Mapps
The View From Somewhere: Essays On Philosophy, Positionality And Power, Moya Mapps
Yale Graduate School of Arts and Sciences Dissertations
The typical analytic philosophy paper is quite reticent about the personal, written as if its author occupied a “view from nowhere.” In a few subfields, however – feminist philosophy, philosophy of disability, critical philosophy of race – it is far more common for philosophers to write openly about how their personal experiences inform their work. In Chapter 1, “Getting Personal,” I argue that we have good reasons, both epistemic and political, to embrace these more openly personal methods of philosophical reasoning and writing. The personal is philosophical. In the remaining chapters I put theory into practice, building philosophical arguments informed …
Statistical Methods For Modelling Structures In High-Dimensional Data From Genetics And Genomics, Chang Su
Statistical Methods For Modelling Structures In High-Dimensional Data From Genetics And Genomics, Chang Su
Yale Graduate School of Arts and Sciences Dissertations
With the advancements in genotyping arrays and high-throughput sequencing technologies, the field of genetics and genomics has witnessed a surge in the collection and analysis of high-dimensional data in recent decades. These data, collected from large cohorts of individuals or tissues with heterogeneous cell types, often encompass complex underlying structures. For instance, major variations in genetic variants capture the ancestry background of profiled individuals, and gene co-expression networks encode the biological functions and molecular mechanisms in tissues and cell types. However, the high-dimensionality and biological complexity of these data present challenges for statistical estimation and inference with traditional methods. To …
The Total Synthesis Of Nenestatin A, Studies Towards The Total Synthesis Of Microansamycin A, And Exploration Of Aminoglycoside Anionic Glycosylation Applicability Using 4-Epi-Vancosamines, Madeline Chellel Frischling
The Total Synthesis Of Nenestatin A, Studies Towards The Total Synthesis Of Microansamycin A, And Exploration Of Aminoglycoside Anionic Glycosylation Applicability Using 4-Epi-Vancosamines, Madeline Chellel Frischling
Yale Graduate School of Arts and Sciences Dissertations
The thesis herein describes a series of synthetic endeavors encompassing different natural product scaffolds and chemical space. In chapter one, I outline the first total synthesis of nenestatin A (10), an isolate featuring the benzo[b]fluorene core found in other atypical angucyclines such as the lomaiviticins and kinamycins. The route development was highly inspired by the synthetic groundwork laid by our laboratory for the lomaiviticin A monomeric unit, utilizing key fragments cyclohexenone (19) and masked quinone (20). Additionally, an adopted radical mediated cyclization furnished the fused ring system following a stereocontrolled aldol addition (59→61). The oxidation state of target nenestatin A …
Visualization Of Infection And Therapies For Sars-Cov-2 Variants Of Concern In Murine Models Of Infection, Kelly Symmes
Visualization Of Infection And Therapies For Sars-Cov-2 Variants Of Concern In Murine Models Of Infection, Kelly Symmes
Yale Graduate School of Arts and Sciences Dissertations
The declaration of the COVID-19 pandemic compelled urgent research into better understanding the causative agent, SARS-CoV-2, and the race for a vaccine and therapeutics for the severely ill. Since its emergence in late 2019, several variants of concern have arisen, characterized in part by their mutations in the spike glycoprotein, that have altered ACE-2 binding efficiency, disease progression and pathogenesis, and viral kinetics. These mutations can also allow for immune evasion from antibodies, highlighting the need to better understand the immune response to infection and a rapid modality to characterize emerging variant pathogenesis and screen potential therapeutics. Here, we introduce …
The Individual Environmental Niche: Drivers, Specialization, And Geometric Configuration, Ben S. Carlson
The Individual Environmental Niche: Drivers, Specialization, And Geometric Configuration, Ben S. Carlson
Yale Graduate School of Arts and Sciences Dissertations
The ecological niche is a central concept for understanding how species will respond to climate and land-use change. Although ecologists traditionally assess niches at the species level, emerging research shows that niche variation below the species level, for example, among individuals and populations, affects many ecological processes, such as population growth rates, community assembly, and ecosystem dynamics. Thus, niche variation may be integral to accurately forecasting biodiversity responses to global change. However, it is largely unknown whether individuals vary in their environmental niches (i.e., niches with axes for environmental conditions such as habitat or land cover) or whether this variation …
Computational Investigations Of Solute And Solvent Transport In Nanoporous Desalination Membranes, Brian Andrew Shoemaker
Computational Investigations Of Solute And Solvent Transport In Nanoporous Desalination Membranes, Brian Andrew Shoemaker
Yale Graduate School of Arts and Sciences Dissertations
Solute and solvent transport through porous membranes is critical to important processes in biology and chemical separation. This is readily apparent in reverse osmosis desalination where nanoporous membranes with high permeability to water and excellent rejection of salt ions are utilized to procure clean, safe water from saline sources. Procuring sustainable worldwide access to an abundant supply of properly treated water is an immediate global concern for human health, economic development, and environmental preservation. Reverse osmosis desalination can play a central role in this pursuit by allowing access to the ample reserves of water in oceans and inland brackish sources, …
Signaling Between Intraepithelial T Cells And Villous Enterocytes In Celiac Disease, Justin Johnson
Signaling Between Intraepithelial T Cells And Villous Enterocytes In Celiac Disease, Justin Johnson
Yale Graduate School of Arts and Sciences Dissertations
Celiac disease (CeD) is a common autoimmune disorder triggered by HLA-DQ2/DQ8-restricted CD4 T cells responding to gluten-derived peptides that have been deamidated by tissue transglutaminase 2 (TG2). These activated CD4 T cells then provide help to B cells that produce IgA antibodies to deamidated gluten peptides (DPG) and TG2. Histologically, the epithelial lining of the small intestinal villi is destroyed by infiltrating cytotoxic T cells (CTLs) that replace the normal resident T cell populations, resulting in villous flattening and absorptive dysfunction. The link between the response of CD4+ T cells to DPGs and the generation, recruitment, and activation of intraepithelial …
Learning Brain Dynamics With Neural Operators, Antonio Henrique De Oliveira Fonseca
Learning Brain Dynamics With Neural Operators, Antonio Henrique De Oliveira Fonseca
Yale Graduate School of Arts and Sciences Dissertations
Understanding the intricate workings of the brain remains one of science's grand challenges. At its core, the brain operates as a dynamic system, with neural oscillations and coordinated activity patterns enabling integrated cognition. However, modeling these complex dynamics computationally has proven difficult. Traditional models often rely on restrictive assumptions about brain activity properties, limiting their utility. This thesis introduces innovative machine learning frameworks, utilizing neural operator techniques specifically designed for neural data, to model brain dynamics more effectively. Neural operators function as mappings between infinite-dimensional spaces, offering a flexible, data-driven approach to capture the complex spatiotemporal relationships in neural dynamics. …
Engineering Nanomaterials For Advanced, Aqueous−Based Applications: Exploring Physical And Chemical Dynamics With A Focus On Surface Chemistry, Junseok Lee
Yale Graduate School of Arts and Sciences Dissertations
Despite recent advancements in water treatment processes, contaminants of emerging concerns (CECs), such as perfluorinated compounds, endocrine disruptors, pharmaceuticals and personal care products, and pesticides, among others, remain a challenge for conventional treatment processes. To address this, tailored, fit−for−purpose water treatment strategies are needed to meet specific raw water quality and end−user needs. Recently, advancements in engineered materials and processes at the nanoscale hold promise towards improving (or even reimagining) related environmental technologies. Nanoscale engineering and materials have been demonstrated to enable unique properties/processes, including high reactivity, allowing for enhanced adsorption, degradation, and filtration – and thus have significant potential …
Defining The Function And Therapeutic Potential Of Mutant Ppm1d In High-Grade Glioma, Matthew A. Murray
Defining The Function And Therapeutic Potential Of Mutant Ppm1d In High-Grade Glioma, Matthew A. Murray
Yale Graduate School of Arts and Sciences Dissertations
There is growing evidence that mutations in the PPM1D gene are implicated in the development and malignancy of tumors, specifically for cancers like high-grade gliomas. These mutations enhance the activity of canonical PPM1D functions, causing the dysregulation of the DNA damage response and cell cycle progression. Recently, PPM1D mutations were reported to cause a synthetically lethal interaction to inhibitors targeting the enzyme, NAMPT, which is critical for NAD+ biogenesis. These mutations lead to global DNA hypermethylation, resulting in the epigenetic silencing of the enzyme NAPRT. Importantly, NAPRT loss was linked to NAMPT inhibitor (NAMPTi) sensitization, making it a biomarker for …
Polymeric Antiscalants For Gypsum Scale Mitigation: Mechanisms And Implication For Membrane Desalination, Julianne Rolf
Polymeric Antiscalants For Gypsum Scale Mitigation: Mechanisms And Implication For Membrane Desalination, Julianne Rolf
Yale Graduate School of Arts and Sciences Dissertations
Water scarcity is one of the biggest threats to humanity, and the global problem is worsening due to population growth, water overuse, pollution, and climate change. Over half of the world’s population suffers from water scarcity at least one month of the year. The problem is further compounded in areas without electricity access. Cape Town’s 2018 “Day Zero” water crisis and Kenya’s 2017 severe drought are indicative of the future. Water conservation alone is not sufficient to meet water demand, especially when power generation is water dependent (e.g., hydropower and fossil fuels). As a result, alternative solutions such as water …
Uncovering Novel Biological Regulators Of Ribosome Biogenesis, Carson J. Bryant
Uncovering Novel Biological Regulators Of Ribosome Biogenesis, Carson J. Bryant
Yale Graduate School of Arts and Sciences Dissertations
Ribosomes are the complex macromolecular machines which assemble proteins in all forms of life, and their production process is known as ribosome biogenesis (RB). In eukaryotes, RB begins in the nucleolus with the transcription of the pre-ribosomal (pre-r)RNA, which undergoes modification, processing, and assembly into mature ribosomes. Malfunctioning RB can cause severe human diseases including rare developmental disorders called ribosomopathies, as well as cancer. Therefore, better understanding of the human RB machinery and its regulation is imperative for pursuing more effective clinical diagnoses and therapies. In this dissertation, I present work which simultaneously advances the field of RB in the …
Engineering The Emergent Properties Of Complex Communities, Chang-Yu Chang
Engineering The Emergent Properties Of Complex Communities, Chang-Yu Chang
Yale Graduate School of Arts and Sciences Dissertations
Microorganisms perform critical functions throughout the biosphere and in biotechnology: from the biogeochemical cycle to the production of sourdough. The overwhelming majority of these functions are usually emergent from the collective outcomes of a large number of microorganisms living in a diverse community. Controlling and manipulating the functions of complex microbial communities is a major aspiration in modern biology. However, we lack a quantitative understanding of how often these functions are emergent, and when it occurs, how we can engineer the emergent properties of microbial communities. In this dissertation, I combine computational approaches with experiments using microbial communities to explore …
Investigating Factors That Influence Food Cue Reactivity In Humans, Emily Elizabeth Perszyk
Investigating Factors That Influence Food Cue Reactivity In Humans, Emily Elizabeth Perszyk
Yale Graduate School of Arts and Sciences Dissertations
The 21st century rise in obesity coincides with the increased prevalence of palatable, energy-dense foods and the ubiquitous cues signaling their availability. Food cue reactivity refers to the responses to these cues – such as increased salivation, brain activity, or the cognitive experience of craving – that become conditioned through prior consumption. Food cue reactivity is highly predictive of food intake and body weight; however, the mechanisms underlying risk are poorly understood. The overarching goal of this dissertation is to investigate factors that influence food cue reactivity in humans. Over three experiments, I examined factors related to the individual or …
Uncovering The Function And Molecular Mechanism Of Mili In Mouse Germline Stem Cells, Yuqi Wang
Uncovering The Function And Molecular Mechanism Of Mili In Mouse Germline Stem Cells, Yuqi Wang
Yale Graduate School of Arts and Sciences Dissertations
Mouse germline stem cells (GSCs) play critical roles in spermatogenesis by self-renewal and differentiation into daughter spermatogonia. Like other stem cells, the proper functions of mouse GSCs are governed by a delicate regulatory network. PIWI proteins belong to the Argonaute protein family, and they act with piRNAs to control gene expression through transcriptional and post-transcriptional regulation. Extensive research has demonstrated the vital functions of PIWI proteins in germline development, stem cell maintenance, and transposon control. Despite this, the role of PIWI in mammalian GSCs remains largely unknown. MILI is one of three murine PIWI proteins. Recent study has discovered that …
The Functional Effects Of Tree And Shrub Mycorrhizal Associations On Soil Organic Matter Dynamics In Forests, Elisabeth B. Ward
The Functional Effects Of Tree And Shrub Mycorrhizal Associations On Soil Organic Matter Dynamics In Forests, Elisabeth B. Ward
Yale Graduate School of Arts and Sciences Dissertations
Plant-fungal associations can strongly influence the composition, persistence, and turnover of soil organic matter in forests. The prevailing framework for understanding these relationships is through the relative abundance of tree mycorrhizal functional types, the vast majority of which associate with arbuscular (AM) and/or ectomycorrhizal (EcM) fungi. Differences in functional traits and ecosystem characteristics between AM and EcM trees have generated immense interest in assessing the ecosystem biogeochemical effects of tree mycorrhizal dominance within and among forest biomes to improve understanding of patterns in soil carbon and nitrogen pools and how they might respond to factors of global change. Yet, forests …
Identifying The Role And Mechanism By Which Gdf15 And Fgf21 Regulate Glucose Homeostasis, Zongyu Li
Identifying The Role And Mechanism By Which Gdf15 And Fgf21 Regulate Glucose Homeostasis, Zongyu Li
Yale Graduate School of Arts and Sciences Dissertations
As a highly utilized substrate in most cells of the body, glucose homeostasis is strictly regulated by a variety of mechanisms. Under physiological conditions, blood glucose is sophisticatedly maintained by temporal coordination of whole-body glucose uptake, absorption from the digestive system, and endogenous glucose production from the liver and kidney. However, the factors and mechanisms by which plasma glucose is regulated under pathological conditions are not clearly understood. In this Ph.D. thesis, we interrogated the role of two cytokines, Growth Differentiation Factor 15 (GDF15) and fibroblast growth factor-21 (FGF-21), in regulating glucose output under extreme metabolic stress. By employing two …
Apoptosis Recognition Receptors Regulate Skin Tissue Repair In Mice, Olivia Justynski
Apoptosis Recognition Receptors Regulate Skin Tissue Repair In Mice, Olivia Justynski
Yale Graduate School of Arts and Sciences Dissertations
The skin is an essential barrier against the outside world, and must withstand constant exposure to damage from the environment. When this barrier is broken, it must be repaired quickly and effectively in order to prevent infection and restore function. The skin’s ability to heal wounds is vital for human health, and insufficient wound treatment is a major clinical problem, contributing to decreased quality of life and increased healthcare costs for many patients due to chronic or non-healing wounds. The complex process of wound healing involves the coordination of many cell types and signals, which were here investigated using single-cell …
Peptide Nucleic Acids And Crispr-Cas9: Mechanisms And Rational Applications For Gene Editing Systems, Nicholas George Economos
Peptide Nucleic Acids And Crispr-Cas9: Mechanisms And Rational Applications For Gene Editing Systems, Nicholas George Economos
Yale Graduate School of Arts and Sciences Dissertations
In the past decade, gene editing technology development has exploded across life sciences fields with promise to advance research, agriculture, industry, and the development of curative human therapeutics. Initially lead by CRISPR-associated nucleases and their ability to induce targeted DNA double-strand breaks (DSBs), the gene editing toolbox continues to grow as new technologies emerge and improve. While the goal of these tools is to precisely manipulate DNA sequences in living cells, not all modifications are created equal. Small or large deletions and insertions, precise nucleotide changes, and combination approaches each entail different challenges and require cooperation with endogenous repair pathways …
Apollon’S Gift: Musical Therapy From Asklepieia To Bīmāristāns, Chihiro Larissa Tsukamoto
Apollon’S Gift: Musical Therapy From Asklepieia To Bīmāristāns, Chihiro Larissa Tsukamoto
Yale Graduate School of Arts and Sciences Dissertations
This dissertation examines the history of music’s use for healing purposes in Antiquity and the Middle Ages and explores the contributions of Islamic medicine on historical musical therapy. It begins in ancient Greece with an examination of polytheistic ancient Greek music and medicine, moves to the role of music in Byzantine healing institutions after the Christianization of Greece, and to its role in bīmāristāns during the Abbasid, Mamluk, and Ottoman periods. Ultimately, it seeks to describe how music was used therapeutically in ancient Greek, Byzantine, and Islamic institutions of healing. Several ancient Greek philosophers believed music could affect the body, …
Classical Sociological Theory Before The 'Fathers': The Radical Materialism Of Miss Harriet Martineau, Elexis Ellis
Classical Sociological Theory Before The 'Fathers': The Radical Materialism Of Miss Harriet Martineau, Elexis Ellis
Yale Graduate School of Arts and Sciences Dissertations
Harriet Martineau was a radical materialist in several respects. Taking the (Baconian) scientific method—avoiding confirmation bias by “bringing together an accumulation of facts previous to the formation of a theory”—to its radical conclusion by extending it to mental phenomena, her (wholly neurophysiological) anti-dualist ontology of human consciousness demolished the division between mental and natural philosophy, the special spiritual status of humans among animals, a clear distinction between thought and perception, & etc. Because it revealed humans—and the mental/physical activity thereof—to be wholly material, and therefore subject to observable laws of nature as any other physical phenomenon, it also made human/social …
Diversity And Distribution Of Herbaceous Plants Along A Tropical Rainfall Gradient In Western Ghats, India, Harikrishnan Venugopalan Nair Radhamoni
Diversity And Distribution Of Herbaceous Plants Along A Tropical Rainfall Gradient In Western Ghats, India, Harikrishnan Venugopalan Nair Radhamoni
Yale Graduate School of Arts and Sciences Dissertations
Tropical forests hold most of the vascular plant life on earth. Much of our understanding on the diversity patterns and drivers of plants in tropical forests is based on studies on trees, which form only a quarter of the plant diversity in these forests. Over 40% of plant diversity in some tropical forests is comprised of understory herbaceous angiosperms (herbs). Despite such high species richness, and their critical role in the functioning of forest ecosystems, our knowledge on the diversity patterns and drivers of herbs is poor, compared to trees. This knowledge gap not only precludes any claim on a …
Pulmonary Delivery Of Mrna Therapeutics, Alexandra Ahova Suberi
Pulmonary Delivery Of Mrna Therapeutics, Alexandra Ahova Suberi
Yale Graduate School of Arts and Sciences Dissertations
Advances in mRNA sequence design and chemical modifications have brought us to theprecipice of translating mRNA therapeutics to treat and cure innumerable human diseases. However, targeting mRNA delivery to relevant tissues remains a major obstacle in the clinical translation of mRNA therapeutics. Topical delivery of mRNA to the respiratory mucosa is an attractive strategy for treating pulmonary disorders. Despite significant interest, there are no approved delivery vehicles capable of efficiently and safely transfecting lung cells with mRNA. In this work, we created a polymer delivery vehicle for mRNA encapsulation and airway delivery. We employed a screening approach to formulate polyplexes …