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Co-Residence, Life-Cycle Savings And Inter-Generational Support In Urban China, Mark Rosenzweig, Junsen Zhang

Discussion Papers

No abstract provided.

Yale Medicine : Alumni Bulletin Of The School Of Medicine, Spring 2014, Yale University. School Of Medicine

Yale Medicine Magazine - alumni bulletin and magazine

This is the Spring 2014 issue of Yale Medicine: alumni bulletin of the School of Medicine, v. 48, no. 2. Prepared in cooperation with the alumni and development offices at the School of Medicine. Earlier volumes are called Yale School of Medicine alumni bulletins, dating from v.1 (1953) through v.13 (1965).

Nota Bene: News From The Yale Library, Yale University Library

Nota Bene

Nota Bene is published during the academic year to acquaint the Yale community and others with the resources of the Yale Library.

Diffuse Reflectance Of Foams, M. A. Devetzoglou, J. R. G. Evans

Journal of Marine Research

There have been few studies of the optical properties of foams but the results of these investigations are of particular relevance to current discussions about climate restoration by means of oceanic foam because they indicate the influence of foam raft number on albedo. The diffuse reflectance of foams prepared from eight surfactants was measured in a 0°/45° geometry with a collimated, solar simulation light source and a photodiode by reference to barium sulphate white standards. Reflectance, or albedo, in the range of 0.5 to 0.59 was recorded for foams prepared with sodium dodecyl sulphate (SDS), methyl cellulose, and TWEEN 20 …

Some Influences Of Remote Topography On Western Boundary Currents, Michael A. Spall

Journal of Marine Research

The influence of topography in a basin interior on the separation and time-dependence of strongly nonlinear western boundary currents is explored using a shallow water numerical model and scaling theory. In the linear limit, the western boundary current follows the western boundary to the latitude of the gap in the interior topography where it then separates from the coast and flows eastward in a narrow jet. As nonlinearity is increased, the flow initially remains steady but develops a series of stationary meanders extending off the western boundary at the separation latitude. For strongly nonlinear flows the solutions become time-dependent. The …

Symmetric Instability Of Cross-Stream Varying Currents, Joseph Pedlosky

Journal of Marine Research

The symmetric instability of a simple shear flow in which the velocity is a linear function of the vertical coordinate but which varies slowly in the cross-stream direction is studied using an asymptotic analytical method. Explicit analytical solutions are found for the evolution of the envelope of the developing linear instability. Although the problem with no lateral variation yields cell-like instabilities growing in place, the lateral variation of the shear produces time dependence and cross-stream propagation of the envelope and accompanying cells. A similar solution is derived for the case of laterally uniform shear in a current whose depth slowly …

Available Energy Of The World Ocean, Peter R. Bannon, Raymond G. Najjar

Journal of Marine Research

The available energy of the ocean is the excess of the sum of the ocean's internal and gravitational energies with respect to its equilibrium state, which is in thermodynamic equilibrium and has the same total entropy as the ocean. The equilibrium state for the world ocean is rigorously determined to be an isothermal ocean with a temperature of 3.66˚C and a horizontally uniform absolute salinity that increases monotonically from 27.30 g kg^–1 at the surface to 47.39 g kg^–1 at a depth of 5.5 km. This salinity profile is consistent with a uniform relative chemical potential of 47.44 …

Anatomy Of A Langmuir Supercell Event, A. E. Gargett, D. K. Savidge, J. R. Wells

Journal of Marine Research

Langmuir supercells (LS), which are Langmuir circulations (LC) extending over full water column depth during storms and revealed by high water column backscatter from surface-origin microbubbles and bottom-origin sediment, were discovered in 2003 during several months of measurements in 15 m of water near the coast of New Jersey. Both the structures themselves and the specific forcing conditions under which they occur have been documented elsewhere. This paper provides an account of the broader oceanographic setting of supercell events, focusing on conditions at the start and end. The start of events is associated with the presence of surface waves of …

A Comparison Of Transport And Position Between The Gulf Stream East Of Cape Hatteras And The Florida Current, A. Sanchez-Franks, C. N. Flagg, T. Rossby

Journal of Marine Research

The Florida Current (FC) transport and Gulf Stream (GS) transport and position have been measured almost continuously for many decades in the Florida Straits at ∼27° N and for the last 20 years at ∼38° N along the Oleander line, respectively. Variations in both currents have been linked to the North Atlantic Oscillation (NAO). Here we show five different proxies for the position of the GS near the Oleander line and find all five measures internally consistent. Further, using a zonally averaged index, the local measurements prove to be good representatives of overall meridional shifting of the current (between Cape …

Effects Of Injury And Nutrition On Sediment Reworking By Clymenella Torquata (Annelida: Polychaeta), Beth R. Campbell, Sara M. Lindsay

Journal of Marine Research

Marine infaunas influence sediment chemistry, nutrient cycling, and microbial communities as they burrow, feed, defecate, and irrigate their tubes and burrows. Nonlethal tissue loss to predators or other disturbances is frequently observed in macrofaunal communities, and previous research has reported significant effects of onetime injury on animal activity. In this study, we examined the effects of injury and nutrient enrichment on sediment reworking rates of a common deposit-feeding polychaete, Clymenella torquata. Individual worms in cores were monitored in a recirculating seawater system, and their defecation and sediment mixing monitored under several experimental conditions. Worms held in control (unenriched) sediment …

Mechanism For Eph-B4 Regulation Of Vein Graft Adaptation, Daniel Lu

Yale Medicine Thesis Digital Library

Introduction

Vein graft adaptation to the arterial circulation entails many changes at the cellular/molecular levels, including both cell proliferation and extracellular matrix (ECM) deposition/remodeling, resulting in thickening of the vein wall, and in excessive cases, pathological neointimal hyperplasia. Eph-B4 is a receptor tyrosine kinase and embryonic determinant of veins that, when stimulated, has been shown by our lab to decrease vein graft wall thickening. We hypothesize that among other mechanisms, Eph-B4 exerts this effect through modulating extracellular matrix production and/or degradation, and that Eph-B4 interacts directly with eNOS to mediate some of its downstream effects.

Methods

Mouse Embryonic Fibroblasts (MEFs) …

Surfactant Enhanced Delivery Of C/Ebp Homologous Protein And Angiopoietin 2 Silencing Rna To Prevent Bronchopulmonary Dysplasia In Mouse Lung, John Gregory Ramirez

Yale Medicine Thesis Digital Library

Objective. To determine if poractant alfa (Curosurf®) could serve as a viable vehicle for silencing RNA (siRNA) delivery. Specifically, we hypothesize that use of Curosurf® as an enhanced delivery vehicle for C/EBP homologous protein (CHOP) and Angiopoietin 2 (Ang2) siRNA would augment gene silencing, preventing cell death and bronchopulmonary dysplasia (BPD) in the mouse lung.

Design. Transfection efficiency of Curosurf® was compared to naked siRNA and Lipofectamine 2000®. MLE-12 cells were transfected with CHOP and Ang2 siRNA using Curosurf®, then exposed to hyperoxic conditions. Cultures were evaluated for respective protein expression and markers of cell death. Curosurf® enhanced siRNA therapy …

Assessing The Survival And Functional Outcomes Of Patients With Supraglottic Squamous Cell Carcinoma, Graeme Michael Rosenberg

Yale Medicine Thesis Digital Library

The objective of this project is to report oncologic and functional outcomes for a cohort of patients with supraglottic squamous cell carcinoma (SSCC) treated in a multidisciplinary setting including the use of transoral laser microsurgery (TLM).

A retrospective observational study at Yale New Haven Hospital, academic teaching hospital was performed. A total of 56 patients without evidence of distant metastasis at presentation treated for SSCC between January 1, 2003 and December 31, 2007 were identified. The main outcome measures include overall survival (OS), locoregional and distant recurrence, and the incidence of tracheostomy and gastrostomy tube requirement.

Of the 56 patients, …

Stress And Rest Spect/Ct Imaging For Evaluation Of Lower Extremity Perfusion: An Index For Evaluation Of Microvascular And Macrovascular Disease, Nataly Sumarriva

Yale Medicine Thesis Digital Library

STRESS AND REST SPECT/CT IMAGING FOR EVALUATION OF LOWER EXTREMITY PERFUSION. Nataly Sumarriva, Wunan Zhou, Mitchel R. Stacy, and Albert J. Sinusas. Section of Cardiology, Department of Internal Medicine, Yale University, School of Medicine, New Haven, CT.

Peripheral arterial disease (PAD) is a progressive atherosclerotic disease of the lower limbs affecting approximately 8 to 10 million Americans. Diabetic patients are twice as likely to develop PAD than are patients without diabetes mellitus (DM) and PAD progression is more rapid in DM patients. The primary goal of this study was to translate image analysis tools previously developed and validated for application …

The Genetic Basis Of Dupuytren's Disease, Gloria Sue

Yale Medicine Thesis Digital Library

Dupuytren's disease is a common heritable connective tissue disorder of poorly understood etiology. It is thought that oxidative stress pathways may play a critical role in the development of Dupuytren's disease, given the various disease associations that have been observed. We sought to sequence the mitochondrial and nuclear genomes of patients affected with Dupuytren's disease using next-generation sequencing technology to potentially identify genes of potential pathogenetic interest. Additionally, we sought to compare the genomes between diseased tissue and blood to look for potential somatic mutations in the diseased tissue. Upon sequencing and subsequent bioinformatics analysis, no differences were observed in …

Inception Cohort Study Of Workers Exposed To Toluene Diisocyanate At A Polyurethane Foam Factory, Wei Gui

Yale Medicine Thesis Digital Library

Background: Isocyanates are one of the most commonly reported causes of occupational asthma; however, the risks of developing isocyanate asthma in modern production facilities remain poorly defined. The purpose of the present investigation was to evaluate TDI exposure and respiratory health among an inception cohort of workers during their first year of employment at a new polyurethane foam production factory.

Methods: Forty-nine newly hired workers were evaluated pre-employment, 6-months, and 12-months post-employment through questionnaire, spirometry and TDI-specific serology. Airborne TDI levels were monitored by fixed-point air sampling and limited personal sampling. Qualitative surface SWYPE tests were performed to evaluate potential …

A Rare View Of Coding Mutations And Plasma Lipid Levels, Aniruddh Pradip Patel

Yale Medicine Thesis Digital Library

A RARE VIEW OF CODING MUTATIONS AND PLASMA LIPID LEVELS. Aniruddh P. Patel, Sekar Kathiresan. Center for Human Genetics Research, Massachusetts General Hospital, Harvard Medical School, Boston, MA and Program in Medical and Population Genetics, the Broad Institute of Harvard and MIT, Cambridge, MA (Sponsored by Richard P. Lifton, Department of Genetics, Yale University School of Medicine, New Haven, CT).

Plasma low-density lipoprotein cholesterol (LDL-C), high-density lipoprotein cholesterol (HDL-C), and triglycerides (TG) are quantitative, heritable risk factors for coronary heart disease. Genome-wide association screens (GWAS) of common DNA sequence variants have identified many loci associated with plasma lipid levels. Targeted …

Mixing By Microorganisms In Stratified Fluids, Gregory L. Wagner, William R. Young, Eric Lauga

Journal of Marine Research

We examine the vertical mixing induced by the swimming of microorganisms at low Reynolds and Péclet numbers in a stably stratified ocean, and show that the global contribution of oceanic microswimmers to vertical mixing is negligible. We propose two approaches to estimating the mixing efficiency, η, or the ratio of the rate of potential energy creation to the total rate-of-working on the ocean by microswimmers. The first is based on scaling arguments and estimates η in terms of the ratio between the typical organism size, a, and an intrinsic length scale for the stratified flow, l = (νκ/N …

The Relation Between Unstable Shear Layer Thicknesses And Turbulence Lengthscales, Eric Kunze

Journal of Marine Research

This note explores the connection between the (i) lengthscales of unstable finescale shear layers which are responsible for turbulence production, (ii) turbulence patch thicknesses and (iii) the outer scales of turbulence, that is, the density overturn (Thorpe) and Ozmidov lengthscales, in the stratified ocean interior. Explanations are offered both for why (i) turbulence patches are often observed to be much thicker than outer turbulence scales and (ii) there is a spectral gap between finescale internal waves and the outer scales of turbulence. A finescale parameterization based on unstable shear predicts Ozmidov lengthscales smaller than unstable-shear-layer thicknesses for moderately unstable gradient …

Refraction Of Swell By Surface Currents, Basile Gallet, William R. Young

Journal of Marine Research

Using recordings of swell from pitch-and-roll buoys, we have reproduced the classic observations of long-range surface wave propagation originally made by Munk et al. (1963) using a triangular array of bottom pressure measurements. In the modern data, the direction of the incoming swell fluctuates by about ± 10° on a time scale of one hour. But if the incoming direction is averaged over the duration of an event then, in contrast with the observations by Munk et al. (1963), the sources inferred by great-circle backtracking are most often in good agreement with the location of large storms on weather maps …

Influence Of Mean Circulation On Large-Scale Decadal Basin Modes, Dhouha Ferjani, Thierry Huck, Alain Colin De Verdière

Journal of Marine Research

The effect of large-scale mean circulation on the generic property of intrinsic basin modes of decadal variability is investigated through linear stability analysis of a two-layer shallow water model over a flat- and a variable-bottom topography. The mean circulation is forced through either surface wind stress or vertical velocities at the layers interface representing surface heat flux. Regardless of the type of forcing, the large-scale mean circulation reduces the damping of the decadal basin modes. The wind forcing mostly affects the mode damping, by up to 30% for a climatological amplitude, whereas the heat flux forcing mostly increases the oscillation …

Diatom Control Of The Autotrophic Community And Particle Export In The Eastern Bering Sea During The Recent Cold Years (2008–2010), Matthew S. Baumann, S. Bradley Moran, Michael W. Lomas, Roger P. Kelly, Douglas W. Bell, Jeffrey W. Krause

Journal of Marine Research

The southeastern Bering Sea has exhibited shifts in climate since the start of the 21st century. The regional climate shifts are manifested in the duration and areal extent of seasonal sea-ice coverage. During a recent cold period (2008–2010) with extensive spring sea-ice cover over the southeastern shelf of the Bering Sea, a total of 77 water column and 24 sediment trap profiles were collected over the shelf and shelf break and analyzed for autotrophic pigment concentrations and elemental (carbon, nitrogen, phosphorus, and silicon) concentrations in suspended and exported particulate material. These results are used to establish the seasonal succession of …

The Transport Of Nutrient-Rich Indian Ocean Water Through The Red Sea And Into Coastal Reef Systems, James H. Churchill, Amy S. Bower, Daniel C. Mccorkle, Yasser Abualnaja

Journal of Marine Research

Driven by upwelling-favorable monsoon winds, nutrient-rich Gulf of Aden Intermediate Water (GAIW) enters the Red Sea from the Indian Ocean each summer. Hydrographic and velocity data acquired in autumn 2011 provide the first indication that GAIW is carried rapidly northward along the eastern Red Sea margin in a well-defined subsurface current with speeds >30 cm s^–1. The nutrient-rich (NO₂ + NO₃ concentrations up to 17 μmol l^–1) GAIW overlaps the euphotic zone and appears to fuel enhanced productivity over depths of 35–67 m. GAIW is broadly distributed through the Red Sea, extending northward along …

Group Behavior Among Model Bacteria Influences Particulate Carbon Remineralization Depths, K. A. S. Mislan, Charles A. Stock, John P. Dunne, Jorge L. Sarmiento

Journal of Marine Research

Organic particles sinking from the sunlit surface are oases of food for heterotrophic bacteria living in the deep ocean. Particle-attached bacteria need to solubilize particles, so they produce exoenzymes that cleave bonds to make molecules small enough to be transported through bacterial cell walls. Releasing exoenzymes, which have an energetic cost, to the external environment is risky because there is no guarantee that products of exoenzyme activity, called hydrolysate, will diffuse to the particle-attached bacterium that produced the exoenzymes. Strategies used by particle-attached bacteria to counteract diffusive losses of exoenzymes and hydrolysate are investigated in a water column model. We …

Simple Models For The Heat Flux From The Atlantic Meridional Overturning Cell To The Atmosphere, M. Behl, D. Nof, S. Van Gorder

Journal of Marine Research

It has been suggested that a slowdown of the Atlantic meridional overturning cell (AMOC) would cause the Northern Hemisphere to cool by a few degrees. We use a sequence of simple analytical models to show that due to the nonlinearity of the system, the simplified heat flux from the modeled AMOC to the atmosphere above is so robust that even changes of as much as 50% in the present AMOC transport are not enough to significantly change the temperature of the outgoing warmed atmosphere (i.e., the fraction of the atmosphere warmed by the AMOC). Our most realistic model (which is …

The Rising Incidence Of Small Endocrine Cancers In The United States: Effects On Surgical Therapy In An Age Of Imaging, Eric Kuo

Yale Medicine Thesis Digital Library

The increasing utilization of imaging technology has led to the diagnosis of cancers earlier in their clinical course. When small tumor size is coupled with relatively indolent histology, excellent oncologic outcomes require the risks of surgery to be carefully considered. However, characteristics and outcomes of small cancers of the thyroid and endocrine pancreas remain poorly defined, and evidence to guide their management is sparse.

Patients with tall cell (mTCV) and diffuse sclerosing (mDSV) variants of papillary thyroid microcarcinoma (mPTC), follicular (mFTC) and Hurthle cell microcarcinoma (mHCC), parathyroid carcinoma (PC) and pancreatic neuroendocrine tumors (PNETs) ≤ 2 cm in size were …

Yale School Of Medicine Facts & Figures 2014-2015, Yale School Of Medicine Office Of Communications

Facts & Figures – annual Yale School of Medicine numbers

Provided by the Office of Communications, the Facts and Figures brochure is produced annually as a way to provide a snapshot of key facts and data related to the School of Medicine as well as the Medical Campus. This includes enrollment data, research activity, financial summaries, and more.

Medicine@Yale March/April 2014 Volume 10, Issue 1, Yale School Of Medicine Office Of Communications

Medicine@Yale - development newsletter

Medicine@Yale : advancing biomedical science, education and health care was a print and online newsletter which published news about academics, research and philanthropy for alumni, donors, faculty, students and the general public. It was initially published 6 times a year and then changed to a quarterly schedule. The first issue came out June/Jul. 2005. The final issue was published in May/June 2022, vol. 17, issue 1. Published by Yale School of Medicine, Office of Communications.

Medicine@Yale December 2014 Volume 10, Issue 3, Yale School Of Medicine Office Of Communications

Medicine@Yale - development newsletter

Medicine@Yale : advancing biomedical science, education and health care was a print and online newsletter which published news about academics, research and philanthropy for alumni, donors, faculty, students and the general public. It was initially published 6 times a year and then changed to a quarterly schedule. The first issue came out June/Jul. 2005. The final issue was published in May/June 2022, vol. 17, issue 1. Published by Yale School of Medicine, Office of Communications.

The Correlation Between Snakebites And Meteorological Variations, Chang Na

Public Health Theses

Background: In the United States, approximately 45,000 snakebites occur annually and affect many people including veterinarians and farmers.1 Snakebites can cause significant pain and morbidity such as severe bleeding and skin necrosis. Better predictive information on snakebite risk could help prevent snakebites by identifying high risk time periods, weather patterns, and locations.

Methods: This was a retrospective analysis of the New Mexico State Poison Control Center data between January 1998 and December 2012. Monthly average meteorological data were obtained from the Parameter-elevation Regressions on Independent Slopes Model climate group. Locations of the bites were categorized as urban or rural based …