Digital Commons Network^™

Disparities In Socioeconomic Context And Response To Antihypertensive Medication In The Antihypertensive And Lipid-Lowering Treatment To Prevent Heart Attack Trial (Allhat), Andi Shahu

Yale Medicine Thesis Digital Library

Where one lives affects one’s blood pressure. Observational studies demonstrate

that living in communities of low socioeconomic status is associated with higher blood

pressure and worse cardiovascular outcomes. In understanding the reasons for these

disparities, a key question is whether evidence-based antihypertensive medication therapy

is less effective in lowering blood pressure and improving cardiovascular outcomes in

lower socioeconomic communities. If so, then anti-hypertensive therapies derived from

randomized clinical trials (RCTs) may be suboptimal in achieving expected outcomes.

Despite standardized protocols and balancing of demographic and clinical characteristics

between study arms of RCTs, the socioeconomic environment in which people live is …

Role Of The Rna Modification N6-Methyladenosine In Normal Hematopoiesis & Disease, Radovan Vasic

Yale Medicine Thesis Digital Library

N6-methyladenosine (m6A) is the most abundant modified nucleotide occurring in mRNA, with key roles in RNA metabolism and regulation of gene expression. Proposed effects of m6A modification of RNA transcripts include effects on transcript half-life, translation efficiency, splicing and miRNA biogenesis. Importantly, m6A is the only known dynamic RNA modification, with deposition mediated by the “writer” METTL3, and demethylation carried out by the “erasers” ALKBH5 and FTO. We hypothesized a role for m6A in hematopoiesis, with potential disease relevance in myeloid malignancies.

To gain an understanding of the effects of m6A on normal hematopoiesis and myeloid malignancies such as the …

Photodynamic Therapy For Cutaneous Squamous Cell Carcinoma In-Situ & Mutation Burden Analysis, Yuemei Zhang

Yale Medicine Thesis Digital Library

PHOTODYNAMIC THERAPY FOR CUTANEOUS SQUAMOUS CELL CARCINOMA IN-SITU & MUTATION BURDEN ANALYSIS. Yuemei (Amy) Zhang, Mei Zhong, Haifan Lin, and Sean Christensen. Department of Dermatology, Yale University School of Medicine, New Haven, CT.

SCC in-situ (SCCIS), or Bowen’s disease, is a precursor to invasive squamous cell carcinoma (SCC) of the skin. Compared to other available treatment modalities, photodynamic therapy (PDT) may offer comparable efficacy with decreased morbidity and better cosmetic and functional outcomes. This retrospective study analyzes the effectiveness and outcomes of photodynamic therapy with aminolevulinic acid (ALA-PDT) treatment of cutaneous squamous cell carcinoma in-situ (SCCIS) with blue light. Data …

Orally-Dosed Citalopram Stimulates Small Intestinal Mucosal Growth, Lucy Zhang

Yale Medicine Thesis Digital Library

Parenterally-administered selective serotonin reuptake inhibitors (SSRI), such as citalopram, increase intestinal mucosal absorptive surface by day 7 of treatment. We hypothesized that enteral citalopram would also induce intestinal mucosal growth, thus allowing for therapy with an oral agent. In the study’s first phase, C57BL/6 mice received peanut butter (PB) pellets containing 10, 50, or 100 mg/kg/day citalopram for 7 days; or 25 mg/kg/day citalopram for 14 or 21 days; or plain PB pellets for 7, 14, or 21 days. In the second phase, C57BL/6 mice received 0, 10, 25, or 50 mg/kg/day citalopram in drinking water for 2, 3, 6, …

Reproductive Health And Fertility Among Transgender Adolescents: A Knowledge And Attitudes Survey, Aimee Alphonso

Yale Medicine Thesis Digital Library

The goal of this study was to determine the knowledge and attitudes of transgender adolescents regarding fertility and future parenthood. We developed and administered a cross-sectional questionnaire to a convenience sample of 23 transgender and gender non-conforming adolescents (mean age 16.2 ± 2.6) who attended the Yale Pediatric Gender Program between October 2016 and August 2017. Our results indicate that transgender adolescents have a basic understanding of reproductive health and fertility (mean total knowledge score of 3.78 ± 0.80 out of 5). Knowledge scores were significantly higher in participants with previous information about gender-affirming hormone therapy (GAH; p

State Of Israel, United States: Securities And Exchange Commission (Sec)

Documents

No abstract provided.

Climate And Sustainability Framework, City Of New Haven, January 2018, Emily Wier, Krysia Solheim, Anna Lipin, Elsa Rose Farnam, Dawn Henning

Reports

No abstract provided.

Why Is The Ocean Surface Slightly Warmer Than The Atmosphere?, Lakshika Girihagama, Doron Nof

Journal of Marine Research

How much warmer is the ocean surface than the atmosphere directly above it? The present study offers a means to quantify this temperature difference using a conceptual nonlinear one-dimensional global energy balance coupled ocean–atmosphere model ("Aqua Planet"). The significance of our idealized model, which is of intermediate complexity, is its ability to obtain an analytical solution for the global average temperatures. Our analytical model results show that, for the present climate, predicted global mean ocean temperature is 291.1 K whereas surface atmospheric temperature above the ocean surface is 287.4 K. Thus, the modeled surface ocean is 3.7 K …

High-Frequency Variability In The North Icelandic Jet, B. E. Harden, R. S. Pickart

Journal of Marine Research

We describe the high-frequency variability in the North Icelandic Jet (NIJ) on the Iceland Slope using data from the densely instrumented Kögur mooring array deployed upstream of the Denmark Strait sill from September 2011 to July 2012. Significant sub-8-day variability is ubiquitous in all moorings from the Iceland slope with a dominant period of 3.6 days. We attribute this variability to topographic Rossby waves on the Iceland slope with a wavelength of 62 ± 3 km and a phase velocity of 17.3 ± 0.8 km/day^–1 directed downslope (–9° relative to true-north). We test the theoretical dispersion relation for these …

Self-Efficacy And Dependence In Personal & Clinical Relationships: A Qualitative Analysis Of Narratives About Life With Chronic Back Pain, Elizabeth Cummings

Yale Medicine Thesis Digital Library

Objectives: People with chronic back pain encounter considerable psychological and social challenges. Through personal narratives, this project examines the ever-evolving relationship between chronic back pain, sense of self-efficacy, and perceived role in interpersonal relationships, both in the community and within the health care system.

Methods: In-person semi-structured interviews were conducted with 20 adult patients attending a specialized interventional spine pain clinic. The interview transcripts were subjected to inductive thematic analysis, and themes were labeled descriptively. Participant responses were intentionally not analyzed within the context of an existing theoretical framework, so that the content of participant responses would directly drive the …

Smoking Cessation And Outcome After Ischemic Stroke Or Tia, Katherine Abigail Epstein

Yale Medicine Thesis Digital Library

People who smoke cigarettes are 2-4 times more likely to have a stroke and 2-5 times more likely to have a myocardial infarction compared with people who do not smoke. On a population level, it is estimated that smoking accounts for 33% of all cardiovascular deaths. Fortunately, quitting smoking can rapidly normalize risk. After an MI, smoking cessation reduces the risk of recurrent coronary events to the level of a never-smoker's after 3 years. While the benefits of smoking cessation in patients with cardiovascular disease are well-known, the benefits of smoking cessation after stroke have never been adequately examined and …

Medicine@Yale September/October 2018 Volume 14, Issue 3, Yale School Of Medicine Office Of Communications

Medicine@Yale - development newsletter

Medicine@Yale : advancing biomedical science, education and health care was a print and online newsletter which published news about academics, research and philanthropy for alumni, donors, faculty, students and the general public. It was initially published 6 times a year and then changed to a quarterly schedule. The first issue came out June/Jul. 2005. The final issue was published in May/June 2022, vol. 17, issue 1. Published by Yale School of Medicine, Office of Communications.

Yale Medicine : Alumni Bulletin Of The School Of Medicine, Autumn 2017, Yale University. School Of Medicine

Yale Medicine Magazine - alumni bulletin and magazine

This is the Autumn 2017 issue of Yale Medicine: alumni bulletin of the School of Medicine, v. 52, no. 1. Prepared in cooperation with the alumni and development offices at the School of Medicine. Earlier volumes are called Yale School of Medicine alumni bulletins, dating from v.1 (1953) through v.13 (1965).

Rbi Annual Report 2016-17, Reserve Bank Of India

Documents

No abstract provided.

Estimating Aging Effects In Running Events, Ray C. Fair, Edward H. Kaplan

Cowles Foundation Discussion Papers

This paper uses world running records by age to estimate a biological frontier of decline rates. Two models are compared: a linear/quadratic (LQ) model and a non-parametric model. Two estimation methods are used: 1) minimizing the squared difference between the observed records and the modeled biological frontier and 2) using extreme value theory to estimate the biological frontier that maximizes the probability of observing the existing world records by age. The results support the LQ model and suggest there is linear percentage decline up to the late 70’s and quadratic decline after that. The extreme value estimates suggest that the …

The Impact Of Social Support On Diet Quality In Stroke Survivors, Sarah Rocks

Yale School of Medicine Physician Associate Program Theses

Stroke is a leading cause of death and disability in the United States, and nearly 25% of strokes are repeat events. Secondary prevention strategies are needed to reduce the disabling sequelae of recurrences. Dietary modification to include more fruits, vegetables, and polyunsaturated fats is a promising tactic. If stroke leads to disability, patients may not be able to cook or grocery shop for themselves. Thus, one factor that may influence diet quality is social support, but its effect on post-stroke diet has not been assessed. In this cross-sectional study, we will examine the association between social support and diet quality …

The Best And Worst Of All Possible Worlds: Some Crude Evaluations, Martin Shubik, Michael R. Powers

Cowles Foundation Discussion Papers

The 2 x 2 matrix game plays a central role in the teaching and exposition of game theory. It is also the source of much experimentation and research in political science, social psychology, biology and other disciplines. This brief paper is addressed to answering one intuitively simple question without going into the many subtle qualifications that are there. How efficient is the non-cooperative equilibrium? This is part of a series of several papers that address many of the qualifications concerning the uses of the 2 x 2 matrix games.

An Assessment Of Théologie Totale, Vincent P. Williams

Yale Divinity School Theses

This thesis critically assesses Sarah Coakley’s proposed “théologie totale,” especially as articulated in God, Sexuality, and the Self and her 2015 Warfield Lectures. It advances four aims: (1) to analyze how Coakley’s privileging of contemplative prayer and her broad interdisciplinarity work together; (2) to situate and contextualize her claims by placing them in dialogue with Friedrich Schleiermacher’s theological method, noting convergences in experience-based starting points; (3) to evaluate contemplation as a methodological locus using Jean-Yves Lacoste’s phenomenology of prayer and Miranda Fricker’s account of epistemic injustice; and (4) to reflect on the implications of Coakley’s method for future systematic work. …

Relational Power, Music, And Identity: The Emotional Efficacy Of Congregational Song, Nathan Myrick

Yale Journal of Music & Religion

Relational Power, Music, and Identity: The Emotional Efficacy of Congregational Song

The power of congregational song to unify (or divide) people along various lines is well documented. Yet, how this process of uniting or dividing is accomplished has proven necessarily difficult to document. This paper examines the complex and polyvalent factors that contribute to the meaningfulness of congregational music making, seeking to offer a synthetic, conceptual framework with which to engage this often murky milieu.

Employing interdisciplinary research techniques drawn from sociology, ritual studies, and ethnomusicology, I construct a conceptual framework with which to understand the profoundly formative power of …

Yale Medicine : Alumni Bulletin Of The School Of Medicine, Spring 2017, Yale University. School Of Medicine

Yale Medicine Magazine - alumni bulletin and magazine

This is the Spring 2017 issue of Yale Medicine: alumni bulletin of the School of Medicine, v. 51, no. 3. Prepared in cooperation with the alumni and development offices at the School of Medicine. Earlier volumes are called Yale School of Medicine alumni bulletins, dating from v.1 (1953) through v.13 (1965).

Land Conservation In A Changing Climate:Stewardship Science And Financing, Bradford S. Gentry, Shelley Clark, Colin Kelly, Joshua Morse

Yale School of the Environment Publications Series

Report of the 2016 Berkley Workshop

Held at the Pocantico Center of the Rockefeller Brothers Fund, Tarrytown, NY - July 2016

Penetrance Estimates For Incidental Genomic Findings In Acmg-59, James A. Diao

Yale Day of Data

The dropping costs and rising popularity of next-generation sequencing has introduced the possibility of personalizing medical treatments and screening for genetic diseases. Still, the clinical community’s understanding remains incomplete, with limited consensus on the proper interpretation for many genetic variants. Thus, the standard procedure when returning sequencing results has been to report findings only in genes related to the diagnostic indication, and not incidental findings in other genes. To balance the threat of false positives with the medical benefits of true findings, the American College on Medical Genetics and Genomics (ACMG) recommends an exception: that clinical sequencing laboratories seek and …

Safer Chemicals Design Diagrams, Longzhu Shen, Fjodor Melnikov, John Roethle, Aditya Gudibanda, Richard Judson, Julie Zimmerman, Paul Anastas

Yale Day of Data

The NRF2-ARE antioxidant pathway is an important biological sensing and regulating system that responds to chemical insults. At minute level, it protects a living species to go through hard environmental conditions. However, when the external disruption exceeds the inherent resilience, cellular damage can occur, eventually leading to cytotoxicity. Therefore, studying the likelihood of a chemical activating the NRF2-ARE pathway is interesting to discovering therapeutic agents and designing safer chemicals. In this research, we engaged a combination of computational chemistry, statistical learning and mechanistic toxicology to estimate the likelihood of a chemical to perturb this critical toxicological pathway and derive a …

Do Elephants Eat More Trees When Less Grass Is Available? A Field Study In Kruger National Park, South Africa., Emily Goldberg

Yale Day of Data

Although African bush elephants are often responsible for the majority of herbivore-driven savanna tree mortality, confusion remains regarding the factors that influence their diet. Some elephants either browse or graze almost exclusively, while others balance the two, and the determinants of this variation remain poorly understood. I seek to determine whether grass availability controls the proportion of woody plants in elephant diet and, therefore, the amount of damage elephants do to trees while foraging. Preliminary analysis using already-available data on grass biomass, elephant density, and elephant damage to trees suggest that tree damage is in fact negatively correlated with grass …

Macrobenthos Community Succession In The Northern Gulf Of Mexico Hypoxic Regions: Testing The Pearson-Rosenberg Model, Shivakumar K. Shivarudrappa, Kevin B. Briggs

Journal of Marine Research

The Pearson and Rosenberg (P-R) conceptual model of macrobenthic succession was used to assess the impact of hypoxia (dissolved oxygen concentration ≤2 mg L^–1) on the macrobenthic community on the continental shelf of the northern Gulf of Mexico. The stress-response relationship between bottom-water oxygen concentration and the macrobenthic community was used to determine the ecological condition of the benthic habitat. In lieu of testing the effect of decreasing influence of organic enrichment on the macrobenthic community as a function of distance from the source of organic pollution, we tested the effect of bottom-water dissolved oxygen concentration as a …

The Sea: The Science Of Ocean Prediction, Nadia Pinardi, Pierre F. J. Lermusiaux, Kenneth H. Brink, Ruth H. Preller

Journal of Marine Research

At the beginning of the 20th century Vilhelm Bjerknes defined the “ultimate problem ofmeteorology and hydrography” as the discovery of “the laws according to which an atmospheric or hydrospheric state develops out of the preceding one” and the “precalculation of future states” from gridded analyzed observations—that is, forecasting. The development of the electronic computer and the vision of several meteorologists allowed the transformation of meteorology into a sophisticated scientific discipline based on physics and mathematics. The first successful meteorological forecast was carried out in the 1950s. Meteorological forecasting became an operational activity at the end of the 1960s. The contributions …

Some Considerations About Coastal Ocean Observing Systems, K. H. Brink, Anthony R. Kirincich

Journal of Marine Research

Coastal ocean observing capabilities are evolving rapidly, both in terms of sensors and in terms of the volume of information available. We discuss the aspects of the coastal ocean that make it a unique environment, both in terms of physical processes and measurement techniques. Although many global-level systems are relevant to the coastal ocean, we concentrate on treating systems that are unique to the continental shelf environment. Further, we briefly discuss examples of measurement systems that would be useful for developing and driving ocean prediction systems.

Langmuir Supercells On The Middle Shelf Of The South Atlantic Bight: 1. Cell Structure, D. K. Savidge, A. E. Gargett

Journal of Marine Research

Langmuir circulation cells extending through entire water columns exert a profound influence on sediment transport on shallow shelves, hence their designation as "Langmuir Supercells" (LSs) upon discovery in 2004 in water of 15 m depth at the Long-Term Ecosystem Observatory (LEO) off New Jersey (United States). Until now, similar high-frequency, full water column measurements of turbulent velocities and density fields have not been reported from significantly deeper continental shelf environments. Such deeper measurements are needed to determine whether LSs exist to influence sediment transport outside the inner shelf. In this article, that deficiency is addressed, using measurements from a midshelf …

A New Era For The Sea, K. H. Brink, James J. Mccarthy

Journal of Marine Research

Now in its 80th year of publication, Journal of Marine Research has always striven to serve the oceanographic community by publishing papers vital to the marine research in the long and rich tradition of the Sears Foundation for Marine Research. As such, with this special issue we bring into the fold The Sea, the long-standing highly respected series that provides a continuing, comprehensive, and timely synthesis of the state of knowledge of ocean science...

Rainfall Effect On Sediment And Nutrient Fluxes In A Small Mangrove River, Okinawa, Japan, Kazumi Terada, Yukio Koibuchi, Masahiko Isobe

Journal of Marine Research

To understand the effect of rainfall on sediment and nutrient fluxes in a mangrove river ecosystem, field observations were conducted in the Fukido River, Okinawa, Japan. Water currents and water quality parameters (salinity and turbidity) were measured at the river mouth and upstream, and surface water samples were analyzed for nutrient concentrations (NO₃-N, NH₄-N, PO₄-P, SiO₂-Si, suspended solids [SS], total nitrogen [TN], and total phosphorus [TP]). Observations were conducted on both clear and rainy days, which revealed the effect of weather. SS flux at the river mouth (outflux to sea) and upstream …