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Tobacco Use, Knowledge Of Tobacco Risks, And Perception Of Smoking Behaviors Among Urban And Rural Youth In South Sulawesi, Indonesia, Ryan Andrew Sutherland

Public Health Theses

This observational study surveyed knowledge, practice, and attitudes (KAP) of N=959 youth 13 – 18 years of age in South Sulawesi, Indonesia and assessed how age, sex, familial smoking status, friend group smoking status, teacher smoking status, parental education, parental employment, exposure to tobacco-related advertisements, access to internet-connecting technological devices (INT-D) and television, and monthly pocket money were associated with youths’ perceptions of tobacco users and smoking, knowledge of tobacco health risks, and smoking status. This study also examined how urban or rural environment and schooling — access or lack of access to formal education — shaped youths’ decisions to …

Meteorological Determinants Of Mosquito Populations In Connecticut, Melpomene Vasiliou

Public Health Theses

As climate change continues at an alarming rate, it is important to quantify and characterize its wide-ranging impacts at both the global and more localized scales. This study aims to build on this body of evidence that details the local impacts of climate change that have already begun to and will increasingly harm human health. The study explores time trends in Connecticut’s mosquito abundance, as well as potential meteorological determinants of abundance for one key species. Secondary analysis using computational techniques was performed on mosquito abundance data provided by the Connecticut Agricultural Experiment Station (CAES). Simple linear regression was performed …

Promoting Ecosystem And Human Health Under Climate Change ——An Integrated Analysis Of Sustainable Olive Cultivation In Cyprus, Ningjing Wang

Public Health Theses

Achieving agricultural sustainability has become a high priority to ensure society’s current and future food needs without compromising ecosystem health, economic profitability, and human well-being. Organic agriculture has been proposed as an alternative to conventional farming for meeting sustainable goals. However, empirical evidence linking organic farming, human health, and sustainability in the context of climate change is scarce. In addition, previous studies comparing organic and conventional agriculture have not considered the variation in farming practices within the same management regime.

In this study, a multi-criteria sustainability assessment framework with ten indicators has been developed and proposed for sustainable olive cultivation …

Solid Fuel-Related Indoor Air Pollution And Poor Sleep Quality In Adults Aged 45 Years And Older; A National Longitudinal Study In China, Haiqing Yu

Public Health Theses

Background: Sleep disorders are a common public health issue in an aging society. Outdoor air pollution has been linked to poor sleep quality, but few studies have investigated the relationship between indoor air pollution derived from solid fuel combustion and sleep quality in elderly.

Objective: To evaluate the association between indoor air pollution due to cooking solid fuels and sleep quality among adults aged 45 years and elderly in China.

Methods: We analyzed data from the China Health and Retirement Survey (CHARLS), a national survey of ~17,000 residents aged over 45 from 150 counties/districts in China. Participants were restricted to …

Intimate Partner Violence, Colorism, And Stress Coping In Barbados, Nkandu Yumbe

Public Health Theses

Persons who experience intimate partner violence (IPV) have higher rates of chronic disease. This is thought to be due, in part, to the adoption of health risk coping behaviors, as well as the detrimental biological response to chronic stress associated with violence. The role of colorism (perceived skin tone discrimination) in the experiences of victims of IPV, their stress and stress coping behaviors has not previously been examined. The objective of this study was to explore the intersecting experience of black skin, coping strategies and stress among women with IPV histories in Barbados. Women above the age of 18, who …

Accelerometer-Measured Physical Activity And Sedentary Time Among Samoan Adults And Associations With Type 2 Diabetes And Hypertension, Parmida Zarei

Public Health Theses

Objectives: (1) To describe accelerometer-measured physical activity among Samoan adults; (2) to determine associations between physical activity and type 2 diabetes and hypertension; and (3) to assess adherence to global physical activity recommendations.

Participants: Three hundred eighty-five Samoan adults aged 30-72 years.

Setting: Participants were recruited from 23 villages on the Samoan island of ‘Upolu (eight urban, seven peri-urban, and eight rural).

Measurements: Self-reported demographic information including age, census region of residence, and occupation was collected. Anthropometric measurements including weight and height were taken in light island clothing, and body mass index was calculated. Sedentary time, light-intensity physical activity, and …

Generating Contextual Text Embeddings For Emergency Department Chief Complaints Using Bert, David Chang

Yale Day of Data

We applied BERT, a state-of-the-art natural language processing model, on chief complaint data from the Yale Emergency Department to map free-text notes to structured chief complaint categories.

Yale Medicine Magazine, Autumn 2019, Yale University. School Of Medicine

Yale Medicine Magazine - alumni bulletin and magazine

This is the Autumn 2019 issue of Yale Medicine Magazine, v. 54, no. 1. Prepared in cooperation with the alumni and development offices at the School of Medicine. Earlier volumes are called Yale School of Medicine alumni bulletins, dating from v.1 (1953) through v.13 (1965) and Yale Medicine: alumni bulletin of the School of Medicine, v.1 (1965) through v. 52, no.1. (Autumn 2017).

The Function Of Hymns In The Liturgical Life Of Malcolm Quin's Positivist Church, 1878–1905, Paul Watt

Yale Journal of Music & Religion

The publication of Auguste Comte’s positive philosophy in the 1830s and 1840s took the world by storm and has come to be regarded as one of the principal turning points in nineteenth-century intellectual culture. A particularly large number of disciples and imitators of Comte’s philosophy sprang up all over Europe, especially in the United Kingdom. They established churches and networks in Comte’s memory and wrote tracts, pamphlets and books on history, philosophy, aesthetics, literature, theology and the bourgeoning field of sociology based on Comte’s works. One such disciple was the musician Malcolm Quin. A singer, organist and hymn-writer, Quin was …

Yale Medicine Magazine, Summer 2019, Yale University. School Of Medicine

Yale Medicine Magazine - alumni bulletin and magazine

This is the Summer 2019 issue of Yale Medicine Magazine, v. 53, no. 3. Prepared in cooperation with the alumni and development offices at the School of Medicine. Earlier volumes are called Yale School of Medicine alumni bulletins, dating from v.1 (1953) through v.13 (1965) and Yale Medicine: alumni bulletin of the School of Medicine, v.1 (1965) through v. 52, no.1. (Autumn, 2017).

Randomized Controlled Trial Examining Ticagrelor Versus Placebo On Coronary Flow Reserve, Sabrina Puvalowski

Yale School of Medicine Physician Associate Program Theses

Non-obstructive coronary artery disease is prevalent in the United States and is associated with acute coronary syndrome and heart failure. Despite its prevalence and morbidity, no standard therapy exists for non-obstructive coronary artery disease. The development of non-obstructive coronary artery disease involves coronary microvascular dysfunction, which is primarily driven by endothelial dysfunction. Therefore, exploring therapies to improve endothelial function could benefit patients with coronary microvascular dysfunction. Ticagrelor is a P2Y12 inhibitor that is used for its anti-platelet effects and is also thought to improve endothelial function. Therefore, we propose to investigate the effects of ticagrelor versus placebo on coronary flow …

Early, Proactive Palliative Care In Hospitalized Patients With Advanced Dementia: A Research Proposal, Tori Viveen

Yale School of Medicine Physician Associate Program Theses

Dementia is a chronic, progressive and fatal neurodegenerative disease with no curative treatment options. The number of Americans living with dementia is expected to triple between 2018 and 2050. Access to palliative care for patients living with dementia and other chronic diseases like cancer improves quality of life and may even prolong life. However, the optimal timing for a palliative care consult is not yet clear. This study seeks to determine whether early initiation of palliative care in dementia patients admitted to the hospital with acute illness benefits patient clinical outcomes (non-institutionalized days at home, readmissions, location of death) and …

Psilocybin-Assisted Therapy: A Double-Blind Randomized Controlled Trial, Katherine Gruppo

Yale School of Medicine Physician Associate Program Theses

Alcohol use disorder is one of the most prevalent mental health disorders worldwide, treatment options are limited, and relapse rates are high. There remains an urgent need for effective treatments. Research involving the therapeutic potential of classic hallucinogens has reemerged in recent decades and the hallucinogen psilocybin has shown some promise in early studies. We aim to assess the efficacy of psilocybin in treating alcohol use disorder with a 10-week double blind randomized double dummy crossover control trial comparing psilocybin-assisted psychotherapy to ketamine-assisted psychotherapy in individuals with alcohol use disorder. Our primary outcome will be the mean percent heavy drinking …

Brink: A Review Of Books, Issue 5, Chalay Chalermkraivuth, Daniel Judt, Alejandro Nodarse, Margaret (Migs) Grabar Sage, Ashia Ajani, Dimitri Diagne, Nicholas Judt

Brink

No abstract provided.

Yale Medicine Magazine, Spring 2019, Yale University. School Of Medicine

Yale Medicine Magazine - alumni bulletin and magazine

This is the Spring 2019 issue of Yale Medicine Magazine, v. 53, no. 2. Prepared in cooperation with the alumni and development offices at the School of Medicine. Earlier volumes are called Yale School of Medicine alumni bulletins, dating from v.1 (1953) through v.13 (1965) and Yale Medicine: alumni bulletin of the School of Medicine, v.1 (1965) through v. 52, no.1. (Autumn, 2017).

Archivists And Time: Conceptions Of Time And Long-Term Information Preservation Among Archivists, Reine Rydén

Journal of Contemporary Archival Studies

The issue of preserving information about nuclear waste for an extremely long period of time raises questions about ways to transmit knowledge to future generations. There is an ongoing discussion about the design of a message and the sustainability of different storage media. Information preservation in the really long term is, however, only partly a matter of technology; it is just as much about thought patterns. Since the work of archivists plays a key role, it is important to find out how archivists think about time and whether they have more developed conceptions of time and the future than other …

Description Of The Republic Of Argentina, U.S. Securities And Exchange Commission

Documents

No abstract provided.

Physical Laws And Human Behavior: A Three-Tier Framework, Shabnam Mousavi, Shyam Sunder

Cowles Foundation Discussion Papers

Social sciences start by looking at the social-psychological attributes of humans to model and explain their observed behavior. However, we suggest starting the study of observed human behavior with the universal laws of physics, e.g., the principle of minimum action. In our proposed three-tier framework, behavior is a manifestation of action driven by physical, biological, and social-psychological principles at the core, intermediate, and top tier, respectively. More broadly, this reordering is an initial step towards building a platform for reorganizing the research methods used for theorizing and modeling behavior. This perspective outlines and illustrates how a physical law can account …

Gene Co-Expression Networks Analysis Reveal Novel Molecular Endotypes In Alpha-1 Antitrypsin Deficiency, Jen-Hwa Chu, Wenlan Zang

Yale Day of Data

Rationale:Alpha-1 antitrypsin deficiency (AATD) is a genetic condition that predisposes to early onset pulmonary emphysema and airways obstruction. The exact mechanism through which AATD leads to lung disease is incompletely understood.

Objectives: To investigate the effect of AAT genotype and augmentation therapy on bronchoalveolar lavage (BAL) and peripheral blood mononuclear cells (PBMC) transcriptome, while examining the link between gene expression profiles, and clinical features of AATD.

Methods: We performed RNA-Seq on RNA extracted from BAL and PBMC on samples obtained from 89 AATD patients enrolled in the Genomic Research in Alpha-1 Antitrypsin Deficiency and Sarcoidosis (GRADS) study. Differential …

Non-Invasive Analysis Of The Sputum Transcriptome Discriminates Clinical Phenotypes Of Asthma, Xiting Yan

Yale Day of Data

Whole transcriptome wide gene expression profiles in the sputum and circulation from 100 asthma patients were measured using the Affymetrix HuGene 1.0ST arrays. Unsupervised clustering analysis based on pathways from KEGG were used to identify TEA clusters of patients from the sputum gene expression profiles. The identified TEA clusters have significantly different pre-bronchodilator FEV1, bronchodilator responsiveness, exhaled nitric oxide levels, history of hospitalization for asthma and history of intubation. Evaluation of TEA clusters in children from Asthma BRIDGE cohort confirmed the identified differences in intubation and hospitalization. Furthermore, evaluation of the TH2 gene signatures suggested a much lower prevalence of …

A Novel Pathway-Based Distance Score Enhances Assessment Of Disease Heterogeneity In Gene Expression, Yunqing Liu, Xiting Yan

Yale Day of Data

Distance-based unsupervised clustering of gene expression data is commonly used to identify heterogeneity in biologic samples. However, high noise levels in gene expression data and the relatively high correlation between genes are often encountered, so traditional distances such as Euclidean distance may not be effective at discriminating the biological differences between samples. In this study, we developed a novel computational method to assess the biological differences based on pathways by assuming that ontologically defined biological pathways in biologically similar samples have similar behavior. Application of this distance score results in more accurate, robust, and biologically meaningful clustering results in both …

Analyzing Neuronal Dendritic Trees With Convolutional Neural Networks, Olivier Trottier, Jonathon Howard

Yale Day of Data

In the biological sciences, image analysis software are used to detect, segment or classify a variety of features encountered in living matter. However, the algorithms that accomplish these tasks are often designed for a specific dataset, making them hardly portable to accomplish the same tasks on images of different biological structures. Recently, convolutional neural networks have been used to perform complex image analysis on a multitude of datasets. While applications of these networks abound in the technology industry and computer science, use cases are not as common in the academic sciences. Motivated by the generalizability of neural networks, we aim …

A Three State Model Can Explain The Dynamics Of Class Iv Drosophila Dendritic Tips, Sabyasachi Sutradhar

Yale Day of Data

No abstract provided.

Exploring The Ipf Lung Through The Lens Of Single Cell Rna Sequencing, Taylor Adams, Jonas Schupp

Yale Day of Data

This poster illustrates the differences between the IPF disease-specific variety of lung macrophages and the two varieties of macrophages known to reside in the normal human lung.

Erratum

Journal of Marine Research

Please note the correction to the following article: Bouzaiene, Maher, Milena Menna, Pierre-Marie Poulain, and Dalila Elhmaidi. 2018.“Lagrangian dispersion characteristics in the Western Mediterranean.” Journal of Marine Research 5–6, 139–161. https://doi.org/10.1357/002224018826473290.

Vortex Competition In Coastal Outflows, Sean Jamshidi, Edward Johnson

Journal of Marine Research

Experiments and field observations have shown that there are at least two modes of behavior for river plumes. In many cases, the plume turns to the right (in the Northern Hemisphere) on leaving the river mouth and follows the direction of Kelvin-wave propagation. Alternatively, a “bulge” can form in the plume and a fraction of the outflow volume becomes trapped near the mouth. This paper discusses how bulge formation can be affected by the vorticity profile at the river mouth. Due to the image effect, regions of cyclonic vorticity tend to propagate rightwards, whereas regions of anticyclonic vorticity propagate leftward …

The Regulation Of Oxygen To Low Concentrations In Marine Oxygen-Minimum Zones, Don E. Canfield, Beate Kraft, Carolin R. Löscher, Richard A. Boyle, Bo Thamdrup, Frank J. Stewart

Journal of Marine Research

The Bay of Bengal hosts persistent, measurable, but sub-micromolar, concentrations of oxygen in its oxygen-minimum zone (OMZ). Such low-oxygen conditions are not necessarily rare in the global ocean and seem also to characterize the OMZ of the Pescadero Basin in the Gulf of California, as well as the outer edges of otherwise anoxic OMZs, such as can be found, for example, in the Eastern Tropical North Pacific. We show here that biological controls on oxygen consumption are required to allow the semistable persistence of low-oxygen conditions in OMZ settings; otherwise, only small changes in physical mixing or rates of primary …

Advancing Science From Plankton To Whales—Celebrating The Contributions Of James J. Mccarthy, Patricia M. Glibert, Mark A. Altabet, Joseph P. Montoya, Dennis J. Mcgillicuddy Jr.

Journal of Marine Research

Hailing from Sweet Home, Oregon, where his father introduced him to the fascinations of pondwater (McCarthy 2018), Jim McCarthy graduated from Gonzaga University, and in the late 1960s joined the Food Chain Research Group at the Scripps Institution of Oceanography, where he received his doctorate in 1971. The Food Chain Research Group, which was becoming recognized as the premier research group on plankton, was at that time directed by such distinguished scientists as John Strickland and Dick Eppley, among others. The goal of the Food Chain Group was to understand plankton dynamics and trophodynamics, “to a degree that will enable …

Urea Uptake And Urease Activity In The Chesapeake Bay, Caroline M. Solomon

Journal of Marine Research

The importance of urea in supplying the nitrogen (N) required by planktonic communities has long been recognized, notably by James J. McCarthy in studies as early as the 1970s. Utilization of urea involves a two-step enzymatic process in phytoplankton, with urea first entering the cell via transport (i.e., urea uptake), followed by the conversion of urea into ammonium by the enzyme urease. This article describes a series of field observations and experiments conducted in the Chesapeake Bay, USA, from 2001 through 2018, aimed at understanding the relationship between urea uptake and urease activity and the role of environmental factors on …

N-Loss Stoichiometry In A Peru Odz Eddy, Mark A. Altabet, Annie Bourbonnais

Journal of Marine Research

Assuming heterotrophic denitrification as the dominant microbial process, Richards (1965) formulated a stoichiometry governing nitrogen loss in open-ocean oxygen deficient zones (ODZs). It prescribes the quantitative coupling between the oxidation of organic matter by NO^–₃ in the absence of O₂ and the corresponding production of CO₂, N₂, and PO^–3₄. Applied globally, this relationship defines key linkages between the C, N, and P cycles. However, the validity of Richards's stoichiometry is challenged by recognition of complex microbial N processing in ODZs including anammox as an important pathway and nitrite reoxidation. Whereas …