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Knowledge-Driven Personalized Contextual Mhealth Service For Asthma Management In Children, Pramod Anantharam, Tanvi Banerjee, Amit P. Sheth, Krishnaprasad Thirunarayan, Surendra Marupudi, Vaikunth Sridharan

Kno.e.sis Publications

Wide adoption of smartphones and availability of low-cost sensors has resulted in seamless and continuous monitoring of physiology, environment, and public health notifications. However, personalized digital health and patient empowerment can become a reality only if the complex multisensory and multimodal data is processed within the patient context. Contextual processing of patient data along with personalized medical knowledge can lead to actionable information for better and timely decisions. We present a system called kHealth capable of aggregating multisensory and multimodal data from sensors (passive sensing) and answers to questionnaire (active sensing) from patients with asthma. We present our preliminary data …

Using Ehrs For Heart Failure Therapy Recommendation Using Multidimensional Patient Similarity Analytics, Maryam Panahiazar, Vahid Taslimitehrani, Naveen L. Pereira, Jyotishman Pathak

Kno.e.sis Publications

Electronic Health Records (EHRs) contain a wealth of information about an individual patient’s diagnosis, treatment and health outcomes. This information can be leveraged effectively to identify patients who are similar to each for disease diagnosis and prognosis. In recent years, several machine learning methods 1 have been proposed to assessing patient similarity, although the techniques have primarily focused on the use of patient diagnoses data from EHRs for the learning task. In this study, we develop a multidimensional patient similarity assessment technique that leverages multiple types of information from the EHR and predicts a medication plan for each new patient …

Optimizing Performance Of Trainees For Uas Manpower, Interface And Selection (Optumis): A Human Systems Integration (Hsi) Approach, Jennifer Pagan, Dr. Randy Astwood, Cdr Henry Phillips

International Symposium on Aviation Psychology - 2015

Unmanned Aerial System (UAS) operations research by Williams (2004) found that platforms which employ winged aviators (e.g., Predator) have shown higher mishaps than those that select operators that are nonpilots (e.g., Shadow). One explanation may be negative training transfer from manned to unmanned platforms as operators are separated from the aircraft, thus depriving them of a range of sensory cues (McCarley & Wickens, 2007). Another explanation for higher Predator mishaps may be associated with poor Ground Control Station (GCS) design. These varying explanations for differences in mishap rates across platforms indicate the need to address a number of Human System …

Exploring The Mathematical Predictability Of The Advanced Aircraft Training Climate, Preven Naidoo

International Symposium on Aviation Psychology - 2015

Effective pilot training on advanced aircraft is vital in ensuring flight safety, and positive perceptions of the training climate can contribute to the success of the training. Hypothetically, characteristics of the trainee can predict the training climate. Thus far, predictive models have provided little information about the mental viscosity or psychological comfort of the processes of pilot training. The purpose of this study was to develop a mathematical model to predict the psychological comfort of the organisational environment for advanced aircraft pilot transition training using a dichotomous categorical criterion. A predictive model of the phenomena was contemplated from a non-parametric …

Inverting The Human/Automation Equation To Support Situation Awareness And Prevent Loss Of Control, Alez Kirlik, Kasey Ackerman, Ben Seefeldt, Enric Xargay, Donald Talleur, Ronald Carbonari, Naira Hovakimyan, Lui Sha, Anna Trujillo, Irene Gregory

International Symposium on Aviation Psychology - 2015

Despite the contributions of automation to aviation safety and efficiency, the problems associated with technology-centered rather than human-centered automation are well known: decreased pilot situation awareness, deterioration of manual piloting skills, difficulties pilots experience when trying to jump into the loop when needed, and so forth. We present a prototype architecture for human-automation interaction that reverses their traditional roles: in our design, the automation "looks over the shoulder" of the pilot and jumps into the loop when needed rather than the other way around to prevent aircraft loss-of-control (LoC). The architecture exploits the LoC prevention algorithm proposed by Wilborn and …

Characterization Of Calbindin Positive Interneurons Within The Ventral Horn Of The Mouse Spinal Cord, Taylor L. Floyd, David R. Ladle

Celebration of Undergraduate & Graduate Research, Scholarship, and Creative Activities Materials

Sensory-motor circuits in the spinal cord integrate sensory feedback from muscles and modulate locomotor behavior. Although we know how the sensory-motor system generally works, the main issue lies in identifying all neurons involved and understanding their interrelationships. Many interneurons contribute to sensory-motor circuits and have been well studied. For example, Renshaw cells (RC) are inhibitory interneurons that prevent motor neurons from over-activity. A distinguishing feature of RCs is that they are the only interneurons within the ventral-most region of the spinal cord expressing the calcium binding protein calbindin (CB). Recent studies have found other subpopulations of ventral horn interneurons outside …

High Power Pulsed Terahertz Light Generation From Superconducting Antenna Arrays, Nicholas C. Padgett, Stephanie R. Lake, Jason A. Deibel, T. Bullard, D. Latypov, J. Patel, J. Murphy, J. Bulmer, W. Tang, M. Sebastian, Timothy J. Haugan

Celebration of Undergraduate & Graduate Research, Scholarship, and Creative Activities Materials

Terahertz radiation is invaluable in spectroscopy and imaging due to its nondestructive nature. It has become a key focus for those wishing to develop sensors capable of detecting weapons and narcotics unobtrusively and at a distance. An ultrafast pulsed (femtoseconds) laser incident on a superconducting ring causes the emission of terahertz (THz) radiation. It is theorized that the radiation is a result of the supercurrent being modulated by the breaking and recombining of Cooper pairs on the order of picoseconds, where the time scale determines the frequency of the emitted radiation. We propose to investigate the terahertz emission from Yttrium …

Investigation Of Solvent-Dependent Properties Of Donor And Acceptor Materials For Photovoltaic Applications, Anna L. Foote

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The choice of solvent and additive has been shown to affect efficiency of organic solar cell devices. To gain a basic understanding of the role of solvents in influencing overall device performance, we present a comparative study on the physical properties of donor: acceptor mixtures in different solvents. Investigations have been carried out for P3HT (poly(3-hexylthiophene-2,5-diyl)), PTB7 (poly[4,8-bis[(2-ethylhexyl)oxy]benzo[1,2-b:4,5-b']-dithiophene-2,6-diyl][3-fluro-2-[2-ethylhexyl)carbonyl[thieno[3,4-b]thiophenediyl]]), PC61BM ([6,6]-phenyl-C60-butyric acid methyl ester), and PC71BM ([6,6]-phenyl-C70-butyric acid methyl ester). The physical properties reported are based on UV-Vis absorption spectroscopy, resistance measurements, cyclic voltammetry measurements, and surface energy characterizations of the organic films. The solvents used to prepare the organic films …

Determining The Role Of The Ahr In Immunoglobulin Expression And Class Switch Recombination, Bassam Fawaz Kashgari

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The aryl hydrocarbon receptor (AhR) is a ligand-activated cytosolic transcription factor that regulates xenobiotic-metabolizing enzymes. It mediates the toxicity of various environmental chemicals such as 2,3,7,8-tetracholorodibenzo-p-dioxin (TCDD). TCDD inhibits the differentiation of B cells into antibody-secreting cells and inhibits immunoglobulin (Ig) expression in various animal models. We have previously determined that TCDD-induced inhibition of the mouse Ig heavy chain gene (mo-Igh) is AhR-dependent. This inhibition may be mediated by binding of the AhR to dioxin response elements (DREs) within the 3'Igh regulatory region (3'IghRR) and inhibition of 3'IghRR activity, a significant transcriptional regulator of Ig expression. However, there are structural …

An Experimental Investigation On Friction And Scuffing Failure Of Lubricated Point Contacts, Sai Goutham Soma

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Scuffing failure is a catastrophic thermal failure mode induced by the extreme surface temperature of the contacting components. As two mechanical elements roll against each other with high sliding motion, the frictional heat flux elevates the surface temperature to exceed the critical limit, resulting in the welding of the surfaces. The relative motion then tears the welded surfaces apart, causing the damage. Scuffing failure has been an important failure mode for rolling machine elements such as bearings and gears in aerospace applications, owing to the very high operating speeds. Recently, this failure mode has extended to the automotive field, where …

Whole-Lake Primary Production Calculator, Colin D. Leong

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This work describes an implementation of a model for estimation of both benthic and phytoplanktonic primary production in lakes. The web application makes use of interpolation techniques to allow estimates of primary production using values for photosynthesis/irradiance parameters at only 5 depths. These estimates compare favorably in accuracy with estimates using values listed at over one hundred depths. Validation of the implementation was done by comparison with primary production results from the Northern Temperate Lakes Long Term Ecological Research database.

Split Ring Resonator Design For Agricultural Based Applications, Joshua David Compaleo

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Recent advances with manufactured electromagnetic materials known as metamaterials are paving the way to use microwave technology in agricultural development and harvesting. It has been proposed that split ring resonators could be placed on the surface of fruit or vegetables such that the resonant behavior may be monitored and used to estimate the ripeness level. The method is non-destructive and could enable monitoring of large quantities of produce or even be tailored to hand-held devices for consumers. However, the understanding of corresponding changes in the proposed device's resonant behaviors and ripeness levels are limited. In addition, fruit and vegetables are …

Unavoidable Minors Of Large 4-Connected Bicircular Matroids, Deborah Chun, Tyler Moss, Dan Slilaty, Xiangqian Zhou

Mathematics and Statistics Faculty Publications

It is known that any 3-connected matroid that is large enough is certain to contain a minor of a given size belonging to one of a few special classes of matroids. This paper proves a similar unavoidable minor result for large 4-connected bicircular matroids. The main result follows from establishing the list of unavoidable minors of large 4-biconnected graphs, which are the graphs representing the 4-connected bicircular matroids. This paper also gives similar results for internally 4-connected and vertically 4-connected bicircular matroids.

Atmospheric Effects On Radar/Ladar Detection Of Seismic Activity, Michelle Frances Via

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This thesis investigates how well ground vibrations can be detected at ladar or radar wavelengths and how the atmosphere may impact the observation of such activity. First understanding atmospheric hindrances at each of these wavelengths is helpful to prioritize by those yielding best transmission results. A prerequisite to the outdoor field experiment performed for this study involves analyzing atmospheric effects characterization at six probable wavelengths using the Laser Environmental Effects Definition and Reference tool (LEEDR) developed by the Air Force Institute of Technology's (AFIT) Center for Directed Energy (CDE). These wavelengths, selected from the shortwave infrared and microwave portions of …

Laser Guide Star Design Project For The Usaf John Bryan State Park Quad Axis Observatory, Nathan Michael Figlewski

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Atmospheric Turbulence has long remained one of the great unsolved problems in physics. Laser guide stars were invented in order for telescopes to overcome atmospheric turbulence while used in combination with adaptive optics. This study focuses on the design and implementation phase of a Rayleigh laser guide star for the John Bryan State Park Observatory, owned and operated by the United States Air Force. Atmospheric simulations, as well as optical modelling of proposed equipment, were completed to optimize the design of this laser guide star. In addition, a novel method for the implementation of the guide star onto this very …

(261, 105, 42) Abelian Difference Sets Do Not Exist, James Robert Hufford Jr.

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Difference sets in the group Z3 x Z3 x Z37 and the group Z3 x Z9 x Z7 are known not to exist. The only open abelian case with a sylow-3 subgroup rank 2 listed in Vera-Lopez and Sanchez's table is Z3 x Z3 x Z29. We prove for Vera-Lopez and Sanchez's table that difference sets do not exist in the open group allowing the appropriate entry to be "no". We also prove that there exist no difference sets (261, 105, 42) for any group with order 261.

Features For Ranking Tweets Based On Credibility And Newsworthiness, Jacob W. Ross

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We create a robust and general feature set for learning to rank algorithms that rank tweets based on credibility and newsworthiness. In previous works, it has been demonstrated that when the training and testing data are from two distinct time periods, the ranker performs poorly. We improve upon previous work by creating a feature set that does not over fit a particular year or set of topics. This is critical given how people utilize social media changes as time progresses, and the topics discussed vary. In addition, we are constantly gaining new tweet data. Thus, it is important to be …

The Transfer Student Experience: Challenges And Institutional Support Systems For Undergraduate Transfer Students At A Public Four-Year University, Olivia Vanessa Matthews

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The transfer student population is rising on college campuses in the United States. Institutions of higher education should better understand how to support this growing, diverse population. This qualitative study of transfer students investigates what transitional challenges these students face, how they utilize institutional support services to assist them with these challenges, and if they feel appreciated, welcomed, and supported in their new environment. Focus group sessions and a demographic questionnaire were used to obtain data in this study. Participants invited to participate were second term transfer students who began at their current institution during the fall of 2014. Transfer …

Analysis Of The Tapered Transition Waveguide, Ryan J. Shaver

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The tapered transition waveguide is used in waveguide measurement systems for characterizing biaxial electromagnetic properties of materials, but its complex geometry does not support an analytic field solution. To ensure single-mode field behavior, the system includes sections of standard waveguides that only support the dominant mode. As a result, full-wave modeling and simulation of the system is exceedingly large.

Using the finite-element method to analyze the high-order modes at the junctions and to explore field configurations within the transition altering geometry, it is shown that besides the TE10 mode, the TE11 mode is significant. Then, two methods are proposed for …

Logging Debris Protects Sugar Maple (Acer Saccharum) Seedlings From White-Tailed Deer (Odocoileus Virginianus) Herbivory In Wolf-Occupied Forest, Ari Erin Sullivan

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White-tailed deer are a species of great economic and ecological concern. Foresters sometimes leave logging debris known as slash on the forest floor with the intent to protect seedlings from deer herbivory and promote forest regeneration. I examined the effects of slash on rates of deer browsing on sugar maple seedlings in a forest of northern Wisconsin and measured deer foraging behavior using giving-up density and vigilance rates by employing trail cameras. Rates of browsed stems were almost twice as high in the open as within and adjacent to slash. These findings underscore the usefulness of slash for mitigating the …

Accelerated Degradation Of Chlorinated Solvents By Copper-Modified Nanoscale Zero Valent Iron (Cu-Nzvi) Stabilized With Carboxymethyl Cellulose, Andrew Franze

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Nanoscale zero valent iron (nZVI) is a remediation technology that can be used to treat chlorinated hydrocarbons (CHCs) in contaminated aquifers. Nanoparticles remain mobile in water and can be transported with groundwater flow to contaminated zones. However, due to magnetic and van der Waals forces, unstabilized nZVI agglomerates. Carboxymethylcellulose (CMC) was used as a polyelectrolyte stabilizer in this study. nZVI serves as an electron donor and can dechlorinate CHCs. nZVI reactivity with CHCs can be enhanced by addition of a secondary metal catalyst. This study evaluates the potential of copper amended nZVI (Cu-nZVI) to degrade select CHCs. The objective of …

The Impact Of Hsv-1 Infection On Cell Viability, Morphology, And Cd Markers Expression By Unpolarized And Cytokine-Polarized J774a.1 Mouse Macrophages, Sarah Saad Alsharif

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Macrophages play an important role in the immune system, particularly in neutralizing pathogens via phagocytosis and the production of multiple cytokines and chemokines that control infection after exposure to specific stimuli. Macrophages exhibit two different phenotypes, M1 and M2. This study evaluated the role of Suppressors of cytokine signaling (SOCS)1 and SOCS3 on Herpes Simplex Virus (HSV-1) infection of polarized macrophages, cell viability, cell morphology, and the expression of cell surface CD markers. I hypothesized that J774A.1 murine macrophages cells in the naive state (M0), and M1 and M2 phenotypes would display differences in CD markers CD80,CD163, and CD200R, cell …

Stability Of Monomethylmercury In Water, Sarah Elyse Harvey

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Monomethylmercury (MMHg) bioaccumulates in aquatic food webs, leading to concentrations in fish that increase health risks for humans who consume fish. As a result of processes that produce and decompose it, MMHg concentrations are notoriously unstable in many natural waters. I examined the stability of MMHg in both filter-sterilized (< 0.1 µm) reagent-grade water and 0.22-µm filtered sediment pore water from Grand Lake St. Marys, Auglaize and Mercer Counties, Ohio, each at three MMHg treatment concentrations (1, 5, and 50 ng/L). Reagent-grade water samples were incubated under both light and dark conditions at either 5 or 26 °C for 112 days. Pore water samples were incubated in the dark at 26 °C, mimicking environmental conditions, for a period of 98 days. Decay constants (± 95% CI) for solutions containing either 1 or 5 ng/L MMHg in reagent-grade water ranged from 0.0009 ± 0.0013 to 0.1225 ± 0.0150 d-1, with greater decay constants at higher temperature and no significant effect of light exposure. In contrast, decay constants for 50 ng/L MMHg in reagent-grade water were much less than those in more dilute solutions, ranging from 0.0018 ± 0.0015 to 0.0055 ± 0.0023 d-1, with both light and temperature influencing MMHg decomposition. Decay constants of MMHg in pore water were found to be independent of initial concentration of MMHg; however, decay constants in pore water samples were 3-fold higher than those in reagent-grade water amended with the same initial concentration (p = 0.007). These results suggest that natural constituents in pore water accelerate MMHg decay reactions.

Theoretical Throughput Capacity: Capabilities Of Human Information Processing During Multitasking, Aerial N. Camden

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Technological advancements in automation have allowed humans to collect data at exorbitant rates. As a result, human multitasking as become an integral part of many government, industrial, and routine activities. However, multitasking can be difficult to study, primarily due to the lack of objective metrics. The Human Operator Informatic Model (HOIM) is an information-theory based model that has been recently developed to combat these difficulties. The HOIM is based on Shannon information theory and can provide an objective, meaningful measure to describe system complexity and overall multitasking performance. The main goal of this work was to validate the HOIM as …

Identification And Quantification Of The Collagen Type I, Iii And V In Rabbit Patellar Tendons, Mahesh Chandra Kodali

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Tendon injuries pose a great clinical challenge to orthopedic surgeons. Over 200,000 patients undergo tendon repair every year in the United States alone. The role of progression of a tendon injury is multifactorial as a lot of factors come into play during and after the injury at various phases of healing process. There is a still a vast requirement for thorough elucidation and understanding of the pathophysiology and the factors involved in the progression of tendon injury. Although the degenerative role of several MMPs and ADAMTs have been reported, yet there is very less information on the actual role and …

An Improved Adaptive Filtering Approach For Removing Artifact From The Electroencephalogram, Justin Ronald Estepp

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The biophysics of volume conduction that enable electrophysiological data acquisition also result in the mixing of data sources including possible, undesirable noise sources at the electrode interface. This work specifically focuses on improving the performance of the recursive least-squares (RLS) adaptive filtering method for removing eye movement artifact from the electroencephalogram. In biophysically-inspired simulated data, the RLS algorithm is verified to produce results that are inferior to extended infomax independent component analysis (ICA), the most widely used artifact correction approach in this problem space, due to its non-linear filter phase response and the presence of bidirectional contamination, or cross-talk, resultant …

Anterior Cruciate Ligament Biomechanics, Computational Modeling Of Mechanical Behavior And Injury Risk, Bharadwaj Cheruvu

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Knee joint involves interactions from various structures such as cartilage, bone, muscles, ligaments, tendon, as well as neural control. Anterior cruciate ligament (ACL) tears are one of the most frequent soft tissue injuries of the knee. A torn ACL leaves the joint unstable and at risk for further damage to other soft tissues manifested as pain, dislocation, and osteoarthritis. This injury is quite common in sports such as basketball, soccer and football. Females often tear their ACL 2-8 times more frequently than their male counterparts. An ACL injury can be devastating and significantly increases the athlete's risk for osteoarthritis long …

Signal Subspace Processing In The Beam Space Of A True Time Delay Beamformer Bank, Nathan Allen Wilkins

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A number of techniques for Radio Frequency (RF) source location for wide bandwidth signals have been described that utilize coherent signal subspace processing, but often suffer from limitations such as the requirement for preliminary source location estimation, the need to apply the technique iteratively, computational expense or others. This dissertation examines a method that performs subspace processing of the data from a bank of true time delay beamformers. The spatial diversity of the beamformer bank alleviates the need for a preliminary estimate while simultaneously reducing the dimensionality of subsequent signal subspace processing resulting in computational efficiency. The pointing direction of …

Inhibition Of Nectin-1 And Herpes Virus Entry Mediator (Hvem) Using Monoclonal Antibodies Decreases Hsv-1 Entry Into Neuro-2a Cells, Erica Marie Rinehart

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This study examines the effects of blocking the nectin-1 and Herpes Virus Entry Mediator (HVEM) receptors on Neuro-2a (N2a) cells in order to prevent HSV-1 infection. These two receptors have been identified as a primary and secondary mode of entry for HSV-1. Since there was some debate about the correct serum level to be used in growth media for healthy N2a cells, three concentrations (2%, 5%, 10%) were used to examine relative growth and neurite development, in addition to examining possible differences in infectivity levels in all other experiments. There was a difference in general morphology, with neurite abundance and …

Assessment Of The Applicability Of Terahertz Spectroscopic Breath Sensing Towards Monitoring Type 1 Diabetic Mellitus, Jessica Rose Thomas

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Type 1 diabetes is a condition that cumulatively costs around $14.9 billion in medical expenses every year in the United States. Besides being costly, the monitoring of this disease is invasive, painful, and often embarrassing to the afflicted individual; blood and urine testing is currently the daily method of monitoring blood glucose and ketone levels in the body of type 1 diabetics. Though the use of these samples is standard, another avenue for possibly determining blood glucose has not been completely explored. With over 3000 chemicals reportedly found in exhaled human breath, biomarkers associated with this disorder and many of …