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Water System Preparedness For Pandemic Influenza, Phil Van Atta Feb 2008

Water System Preparedness For Pandemic Influenza, Phil Van Atta

Master of Public Health Program Student Publications

This project involved an investigation of water utility preparedness and best practices for pandemic influenza. A pandemic could cause serious disruptions to the operations of critical infrastructure, including drinking water systems. These disruptions could be caused by staffing shortages, power disruptions, and shortages of chemicals and other supplies. Ensuring continuity of operations for drinking water systems is crucial to protect public health and safety, and to the economy of all communities. Literature searches, interviews, and a survey of Ohio water systems indicated that water systems in Ohio and across the United States are preparing for pandemic influenza. Pandemic influenza preparation …

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The Public Health Implications Of Trafficking, Tami Ashbridge Jan 2008

The Public Health Implications Of Trafficking, Tami Ashbridge

Master of Public Health Program Student Publications

Trafficking in human beings is a serious and complex human rights issue. Trafficking for the purpose of sexual exploitation has grave public health implications. The vulnerability of women and children increases their risk of becoming victims of trafficking for the purposes of sexual exploitation. Review of the literature on this subject demonstrates a direct link between the trafficking of women and children for sexual exploitation and the prevalence of HIV/AIDS, STIs and Reproductive/Gynecological Issues, Mental Health, Violence, Abuse and Social Issues. This review supports the concept of human trafficking as a serious public health issue and the need for improved …

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The Response Of Vascular Dermal Enodethial Cells To House Dust Mite Extracts, Aaron Mathew Newman Jan 2008

The Response Of Vascular Dermal Enodethial Cells To House Dust Mite Extracts, Aaron Mathew Newman

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House dust mites are microscopic arthropods that can trigger moderate allergic symptoms such as sneezing, watery eyes, itching, and wheezing in sensitized individuals. People with more serious allergies to house dust mites can develop allergic diseases like atopic dermatitis and asthma. The effects of house dust mites on allergy sufferers make house dust mites and the study of their effects on the human body of great medical and economic importance. A majority of the research that has been done on house dust mite's effects on humans has dealt with the lungs and relevant disease like asthma. Little work has been …

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Human Immunodeficiency Virus-1 Productively Infects Mature Terminally Differentiated Eosinophils In Hiv/Aids Patients, Jude N. Atem Jan 2008

Human Immunodeficiency Virus-1 Productively Infects Mature Terminally Differentiated Eosinophils In Hiv/Aids Patients, Jude N. Atem

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Eosinophils express membrane CD4 protein and can bind HIV-1 glycoprotein (gp) 120. Therefore, eosinophils could serve as host cells for HIV-1 infection in vivo, especially in the late phase of the infection. In culture, HIV-1 infects eosinophil precursors and primary eosinophils. Additionally HIV-1 proviral DNA sequences have been detected in the eosinophils of some HIV-1 positive patients. Since elevated levels of eosinophils occur during HIV-1 infection and parasitic infections, it implies that co-infection of parasites and HIV-1 could cause a much greater increase in the level of potential HIV-1 susceptible eosinophils. Therefore HIV-1 infection of eosinophils could partly explain the …

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The Role Of Phospholipase D (Pld) And Grb2 In Chemotaxis, Katie J. Knapek Jan 2008

The Role Of Phospholipase D (Pld) And Grb2 In Chemotaxis, Katie J. Knapek

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Phospholipase D (PLD) is an enzyme that hydrolyzes phosphatidylcholine yielding choline and phosphatidic acid. PLD is activated by mitogens (lead to cell division) and motogens (leading to cell migration). PLD is known to contribute to cellular proliferation and deregulated expression of PLD has been implicated in several human cancers. PLD has been found to play a role in leukocyte chemotaxis and adhesion as studied through the formation of chemokine gradients. We have established a model of cell migration comprising three cell lines: macrophages RAW 264.7 and LR-5 (for innate defense), and fibroblast COS-7 cells (for wound healing). COS-7 cells respond …

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Mrsa Prevention And Control In County Correctional Facilities In The Greater Dayton Area, Jeffrey Allen Webb Oct 2007

Mrsa Prevention And Control In County Correctional Facilities In The Greater Dayton Area, Jeffrey Allen Webb

Master of Public Health Program Student Publications

Recently there has been an increasing number of methicillin-resistant Staphylococcus aureus (MRSA) cases in correctional facilities around the country, including the Greater Dayton area. Considering the potential health impact of MRSA on correctional facilities it is important that facilities have prevention and control protocols in place. This study summarizes the prevention and control preparedness activities of county correctional facilities in the Greater Dayton area. The positive response rates for the control measures were 88.4% for screening, 83.6% for treatment, 80.6% for personal hygiene, 95.4% for environmental control, 80.4% for education and 84.3% for standard precautions. The study also compared rural …

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Environmental Health Information Systems: More Than Just Gigabytes, Christopher R. Cook Sep 2007

Environmental Health Information Systems: More Than Just Gigabytes, Christopher R. Cook

Master of Public Health Program Student Publications

Environmental health professionals are concerned about bites. Animal bites, mosquito bites, and tick bites to name a few. But what about bytes of data? Environmental health information systems (EHIS) are often the "silent partners" in an environmental health (EH) department's daily protection of public health. By Webster's dictionary definition, a silent partner is a cohort that does not have the right to participate in an organization's management process. The purpose of this study was to encourage public health officials to make EHIS full partners in their EH departments. Through the use of five surveys, this study was designed to increase …

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Vital Signs, Fall 2007, Boonshoft School Of Medicine Aug 2007

Vital Signs, Fall 2007, Boonshoft School Of Medicine

Vital Signs

A twenty-seven page newsletter created by the Boonshoft School of Medicine to document the current affairs of the school. This issue includes a variety of feature articles, alumni profiles, class notes, and more.

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Wsu Research News, Fall 2007, Office Of Research And Sponsored Programs, Wright State University Aug 2007

Wsu Research News, Fall 2007, Office Of Research And Sponsored Programs, Wright State University

WSU Research News

A twenty page newsletter of the WSU Research News. The WSU Research News was published monthly beginning in June of 1968 and issued by the Office of Research Development. This newsletter was created to provide information to the WSU faculty about the availability of outside funds for research and educational programs, new developments that may affect availability of funds, and general information on research and educational activities at Wright State University.

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Wsu Research News, Spring 2007, Office Of Research And Sponsored Programs, Wright State University Apr 2007

Wsu Research News, Spring 2007, Office Of Research And Sponsored Programs, Wright State University

WSU Research News

A twelve page newsletter of the WSU Research News. The WSU Research News was published monthly beginning in June of 1968 and issued by the Office of Research Development. This newsletter was created to provide information to the WSU faculty about the availability of outside funds for research and educational programs, new developments that may affect availability of funds, and general information on research and educational activities at Wright State University.

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Vital Signs, Spring 2007, Boonshoft School Of Medicine Mar 2007

Vital Signs, Spring 2007, Boonshoft School Of Medicine

Vital Signs

A twenty-seven page newsletter created by the Boonshoft School of Medicine to document the current affairs of the school. This issue includes a variety of feature articles, an alumni profile, class notes, and more.

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Out Of "Dark Backrooms And Sheds", Marguerite Maher M.Ed Jan 2007

Out Of "Dark Backrooms And Sheds", Marguerite Maher M.Ed

Electronic Journal for Inclusive Education

Commitment to a single, inclusive education system has been the aspiration of reform in education in a democratic South Africa as articulated in White Paper 6: Special needs education: Building an inclusive education and training system (Department of Education, 2001, referred to hereafter as White Paper 6). Within a ‘barriers to learning’ approach to inclusive education, progress is being made with improved facilities and the implementation of AIDS awareness programmes. Managing the transition towards an inclusive education system has proved challenging in some areas, however, and the specific provision in policy documents directed towards children with disabilities is behind schedule. …

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Hypoxic Induction And The Role Of Hifs In The Activation Of Luciferase Constitutive Reporters In Placental Stem Cells, Diane Michelle Doran Jan 2007

Hypoxic Induction And The Role Of Hifs In The Activation Of Luciferase Constitutive Reporters In Placental Stem Cells, Diane Michelle Doran

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Hypoxia is critically important to the development of the embryo and placenta. Proper placental development is critical for normal fetal growth and embryonic survival. Abnormal placental development has been implicated in numerous obstetric complications, including preeclampsia, which affects about 7% of all pregnancies and can be fatal for both mother and baby. Rodent and murine trophoblast stem cells differentiate into three distinct cell lineages: giant cells, spongiotrophoblasts, and labyrinthine cells, which form different layers and have different functions within the placenta. Recent studies in our laboratory have focused on the invasive giant cell layer using the rodent Rcho-1 choriocarcinoma stem …

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Characteristics Of A Foamy Virus-Derived Vector That Allow For Safe Autologous Gene Therapy To Correct Leukocyte Adhesion Deficiency Type 1, Ryan Matthew Mcnichol Jan 2007

Characteristics Of A Foamy Virus-Derived Vector That Allow For Safe Autologous Gene Therapy To Correct Leukocyte Adhesion Deficiency Type 1, Ryan Matthew Mcnichol

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The hematopoeitic stem cell is a prime target for gene therapy in the attempt to correct a number of single gene inherited genetic defects that affect the immune system. In persons affected by leukocyte adhesion deficiency type 1 (LAD-1) the gene for the Beta-2 subunit of the integrin molecule is mutated. This autosomal recessive gene defect yields a phenotype with little or no beta-2 integrin expression on leukocytes. Beta-2 integrin expression is essential for leukocytes to travel from the blood to the tissues to fight infection. Persons with this disease have lowered leukocyte counts in the tissues and as a …

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Hsv-1 Infection Of C3h Central Nervous System Cell Lines, Lauren Kay Van Buren Jan 2007

Hsv-1 Infection Of C3h Central Nervous System Cell Lines, Lauren Kay Van Buren

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Herpes Simplex Virus Type 1 (HSV-1) can infect the nervous system, resulting in a disease known as herpes encephalitis (HSE). Herpes encephalitis affects thousands of people each year; many cases are fatal or permanently debilitating. Approximately two thousand known cases occur in the United States each year alone (Neuroland online source). Acyclovir has been the drug of choice used to treat herpes encephalitis. Even after the administration of acyclovir, permanent neurological damage and/or death often results. Thousands of individuals would benefit by the discovery of drugs that are more effective at preventing lasting HSE damage and death. Knowledge concerning HSE …

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Discovery Of New Antimicrobial Agents Using Combinatorial Chemistry, William I. Northern Jan 2007

Discovery Of New Antimicrobial Agents Using Combinatorial Chemistry, William I. Northern

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Combinatorial chemistry has become an important aspect of medicinal research due to its flexibility and the ability to produce large numbers of potential therapeutic agents. Once compounds are made, they must be screened to determine if there is any biological activity. This research project focused on developing a screening method for chemical agents produced by a graduate student in the chemistry department at Wright State University. After an acceptable screening method was found, the goal of the project was to determine if compounds produced had either antibacterial activity, antifungal activity, or both. Seven compounds exhibited biological activity. Two of these …

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The Processing Of Β-Endorphin In Morphine Treated Rats Using Seldi-Tof Mass Spectrometry, Jennifer Y. Edwards Jan 2007

The Processing Of Β-Endorphin In Morphine Treated Rats Using Seldi-Tof Mass Spectrometry, Jennifer Y. Edwards

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Endocrine glands secrete peptide hormones that bind to specific receptors, and elicit a response. In the pituitary, prohormone convertases (PC) PC1/3 and PC2 convert inactive prohormones into biologically active peptide hormones. Proopiomelanocortin (POMC) is a precursor molecule that proteolytically cleaves at paired basic residue sites, and produces smaller biologically active peptides, such as adrenocorticotropic hormone (ACTH), α-melanocyte stimulating hormone (α-MSH), and β-endorphin. β-endorphin is an endogenous opioid peptide hormone that plays a vital role in the body's physiological response to stress, fear, and anxiety. Morphine is an exogenous opioid, used for the treatment of moderate to severe pain and competes …

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Flight Physician - July, 2006, Civil Aviation Medical Association Jul 2006

Flight Physician - July, 2006, Civil Aviation Medical Association

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A twenty page newsletter of the Civil Aviation Medical Association. The newsletter provided news about civil aviation medicine and information related to the organization.

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Feasibility Of Gdaha Hospitals Meeting The Surge Capacity And Capability Requirements Of An Avian Flu Pandemic In The Miami Valley, Raymond P. Ten Eyck May 2006

Feasibility Of Gdaha Hospitals Meeting The Surge Capacity And Capability Requirements Of An Avian Flu Pandemic In The Miami Valley, Raymond P. Ten Eyck

Master of Public Health Program Student Publications

Hospital surge capacity is a crucial portion of disaster preparedness planning within a community. The demands generated by a disaster require additional capacity, in the form of beds, equipment, personnel, and special capabilities. The scope and urgency of these requirements must be balanced with a practical approach addressing cost and space concerns. The advent of new infectious disease threats, particularly an avian flu pandemic, have reinforced the need to be prepared for a prolonged surge, lasting six to eight weeks, in addition to the shorter duration surges required for industrial accidents, tornados, chemical disasters and terrorists. Using a standardized data …

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Flight Physician - April, 2006, Civil Aviation Medical Association Apr 2006

Flight Physician - April, 2006, Civil Aviation Medical Association

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A sixteen page newsletter of the Civil Aviation Medical Association. The newsletter provided news about civil aviation medicine and information related to the organization.

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Wsu Research News, Spring 2006, Office Of Research And Sponsored Programs, Wright State University Apr 2006

Wsu Research News, Spring 2006, Office Of Research And Sponsored Programs, Wright State University

WSU Research News

A twelve page newsletter of the WSU Research News. The WSU Research News was published monthly beginning in June of 1968 and issued by the Office of Research Development. This newsletter was created to provide information to the WSU faculty about the availability of outside funds for research and educational programs, new developments that may affect availability of funds, and general information on research and educational activities at Wright State University.

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Alumnews, Spring 2006, Alumni Association, Wright State University Apr 2006

Alumnews, Spring 2006, Alumni Association, Wright State University

AlumNews

Six page issue of the AlumNews newsletter. This newsletter focuses on news about programs, events, and activities for alumni from Wright State University.

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Vital Signs, Spring 2006, Boonshoft School Of Medicine Mar 2006

Vital Signs, Spring 2006, Boonshoft School Of Medicine

Vital Signs

A twenty-eight page newsletter created by the Boonshoft School of Medicine to document the current affairs of the school. This issue includes a variety of feature articles, faculty profiles, class notes, and more.

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Flight Physician - January, 2006, Civil Aviation Medical Association Jan 2006

Flight Physician - January, 2006, Civil Aviation Medical Association

Browse all Civil Aviation Medical Association Newsletters

A twenty page newsletter of the Civil Aviation Medical Association. The newsletter provided news about civil aviation medicine and information related to the organization.

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Assessment Of The Technology Of Genetic Modification In Light Of Its Socio-Economic Implications, Valentina Lootens Jan 2006

Assessment Of The Technology Of Genetic Modification In Light Of Its Socio-Economic Implications, Valentina Lootens

Masters Culminating Experiences (1993-2011)

Since Watson and Crick discovered the “double helix” in 1953, the arguments about the benefits and danger of genetic modification remain largely unanswered, particularly in the relation to food supply. Today, genetic modification or genetic engineering are global issues. Governments, scientific organizations, corporations, research institutions, and scholars hotly dispute the advantages and disadvantages of GM technology. However, unfortunately, the population at large is left in darkness about this new technology and its consequences for human health, environment and society. Moreover, genetic engineering creates a special problem: unlike many new technologies it is irreversible. Once introduced into the food chain, GM …

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In Vitro Toxicity Assessment Of Silver Nanoparticles In Rat Alveolar Macrophages, Cataleya Carlson Jan 2006

In Vitro Toxicity Assessment Of Silver Nanoparticles In Rat Alveolar Macrophages, Cataleya Carlson

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The present study was conducted to assess the toxicity of nanosized silver particles (Ag-15nm, 30nm and 55nm) in rat alveolar macrophages. For toxicity evaluations, cellular morphology, mitochondrial function (MTT assay), membrane leakage (LDH assay) and reactive oxygen species generation (ROS) were assessed after a 24h under control and exposed conditions. The morphological appearance of control and exposed cells were observed by an inverted, phase contrast microscope and the uptake of nanoparticles was observed using the CytoViva Ultra Resolution Imaging (URI) system. Morphological images captured at 100x magnification demonstrated that nanoparticle-exposed cells at higher doses became abnormal in size, and most …

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Susceptibility Of Primary Eosinophils To Infection With Hiv-1 Strain Htlv-Iiib, Jai Govind Marathe Jan 2006

Susceptibility Of Primary Eosinophils To Infection With Hiv-1 Strain Htlv-Iiib, Jai Govind Marathe

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Over the past two decades, much research has been done in the field of human immunodeficiency virus (HIV) and acquired immunodeficiency syndrome (AIDS). However, many of the aspects of pathogenesis of HIV infection and its persistence in the body, despite treatment, remain a mystery. Recent evidence suggests that HIV positive patients develop eosinophilia, especially in the later stages of infection and AIDS. Eosinophils are CD4 positive cells that have the potential to be infected by HIV. Studies have shown that an eosinophilic cell line, AML14.3D10, can be productively infected with a T-cell tropic, CXCR4-using (X4) strain of HIV-1. In this …

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Phenotypic Characterization Of Escherichia Coli Strains Taken From Human Intestinal And Urinary Tracts, Kruthi Murthy Jan 2006

Phenotypic Characterization Of Escherichia Coli Strains Taken From Human Intestinal And Urinary Tracts, Kruthi Murthy

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Escherichia coli (E. coli) is a gram negative bacterium commonly found as a commensal in the intestinal tract of humans and other warm blooded animals. The commensal strains of E. coli are non-pathogenic and do not cause an infection in the host. However, some strains of E. coli are pathogenic and can cause several diseases in humans that include neonatal meningitis, intestinal infections and urinary tract infections. Almost 80-85% of the uncomplicated urinary tract infections are caused by uropathogenic E. coli. Our project involved the characterization of 12 strains of E. coli, isolated from humans in health and disease. These …

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A Modular Approach To Document Indexing And Semantic Search, Dhanya Ravishankar, Krishnaprasad Thirunarayan, Trivikram Immaneni Jul 2005

A Modular Approach To Document Indexing And Semantic Search, Dhanya Ravishankar, Krishnaprasad Thirunarayan, Trivikram Immaneni

Kno.e.sis Publications

This paper develops a modular approach to improving effectiveness of searching documents for information by reusing and integrating mature software components such as Lucene APIs, WORDNET, LSA techniques, and domain-specific controlled vocabulary. To evaluate the practical benefits, the prototype was used to query MEDLINE database, and to locate domain-specific controlled vocabulary terms in Materials and Process Specifications. Its extensibility has been demonstrated by incorporating a spell-checker for the input query, and by structuring the retrieved output into hierarchical collections for quicker assimilation. It is also being used to experimentally explore the relationship between LSA and document clustering using 20-mini-newsgroups and …

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Rural Methamphetamine Abuse: An Ethnographic Perspective, Rocky L. Sexton, Robert G. Carlson Jun 2005

Rural Methamphetamine Abuse: An Ethnographic Perspective, Rocky L. Sexton, Robert G. Carlson

Population and Public Health Sciences Faculty Publications

No abstract provided.

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