Digital Commons Network^™

Brain, Heart, And Sudden Death, Shahram Oveisgharan, Fariborz Ghaffarpasand, Peter Sörös, Mustafa Toma, Nizal Sarrafzadegan, Vladimir Hachinski

Neuroscience Institute Publications

During the past 30 years, rate of coronary artery disease (CAD), as the main cause of sudden death (SD), has decreased more than rate of SD. Likewise, cause of SD remains elusive in not a trivial portion of its victims. One possible reason is attention to only one organ, the heart, as the cause of SD. In fact, SD literature focuses more on the heart, less on the brain, and seldom on both. A change is required. In this paper, we first review the pathological findings seen in heart autopsies of SD victims after psychological stressors such as physical assault …

School's Out: Parenting Stress And Screen Time Use In School-Age Children During The Covid-19 Pandemic, Diane Seguin, Elizabeth Kuenzel, J. Bruce Morton, Emma G. Duerden

Paediatrics Publications

Background During the COVID-19 pandemic, millions of children abruptly moved to online schooling, which required high levels of parental involvement. Family routines were disrupted, potentially increasing parental stress, and may be reflected in greater media screen time use in children. Objectives To determine whether (1) parenting styles and (2) parenting stress were associated with children's screen time use during the pandemic compared to the pre-pandemic period. Methods Parents (> 18 years of age) were recruited to complete an online survey regarding changes in their children's (6–12 years) screen time use and daily activities before and during the pandemic. Stress and …

Disentangling Language Status And Country-Of-Origin Explanations Of The Bilingual Advantage In Preschoolers, Isu Cho, Jewan Park, Hyun Joo Song, J. Bruce Morton

Paediatrics Publications

Bilingual preschoolers from East Asia outperform monolingual preschoolers from North America or Europe in executive functioning tasks, which has been interpreted as evidence of a bilingual advantage in executive functioning. This study tested whether these differences actually reflect country-of-origin effects given that East Asian preschoolers frequently outperform North American or European children in executive functioning tasks. Consistent with previous findings, Korean–English bilingual preschoolers made fewer errors in an age-appropriate executive functioning task than did English monolingual children in Canada. However, Korean–English bilingual preschoolers performed comparably to Korean monolingual preschoolers in Korea. Differences between Korean and Canadian children's executive functioning were …

Factors Associated With Parents’ Experiences Using A Knowledge Translation Tool For Vaccination Pain Management: A Qualitative Study, Nicole E. Mackenzie, Perri R. Tutelman, Christine T. Chambers, Jennifer A. Parker, Noni E. Macdonald, C. Meghan Mcmurtry, Pierre Pluye, Vera Granikov

Paediatrics Publications

Background: Vaccination is a common painful procedure for children. Parents’ concern regarding vaccination pain is a significant driver of vaccine hesitancy. Despite the wealth of evidence-based practices available for managing vaccination pain, parents lack knowledge of, and access to, these strategies. Knowledge translation (KT) tools can communicate evidence-based information to parents, however little is known about what factors influence parents’ use of these tools. A two-page, electronic KT tool on psychological, physical, and pharmacological vaccination pain management strategies for children, was shared with parents as part of a larger mixed methods study, using explanatory sequential design, exploring factors related to …

Early Protein Intake Predicts Functional Connectivity And Neurocognition In Preterm Born Children, Emma G. Duerden, Benjamin Thompson, Tanya Poppe, Jane Alsweiler, Greg Gamble, Yannan Jiang, Myra Leung, Anna C. Tottman, Trecia Wouldes, Steven P. Miller, Jane E. Harding, Jane M. Alsweiler, Janene B. Biggs, Coila Bevan, Joanna M. Black, Frank H. Bloomfield, Kelly Fredell, Greg D. Gamble, Jane E. Harding, Sabine Huth, Yannan Jiang, Christine Kevan, Myra Leung, Geraint Phillips, Tanya Poppe, Jennifer A. Rogers, Heather Stewart, Benjamin S. Thompson

Brain and Mind Institute Researchers' Publications

© 2021, The Author(s). Nutritional intake can promote early neonatal brain development in very preterm born neonates (< 32 weeks’ gestation). In a group of 7-year-old very preterm born children followed since birth, we examined whether early nutrient intake in the first weeks of life would be associated with long-term brain function and neurocognitive skills at school age. Children underwent resting-state functional MRI (fMRI), intelligence testing (Wechsler Intelligence Scale for Children, 5th Ed) and visual-motor processing (Beery-Buktenica, 5th Ed) at 7 years. Relationships were assessed between neonatal macronutrient intakes, functional connectivity strength between thalamic and default mode networks (DMN), and neuro-cognitive function using multivariable regression. Greater functional connectivity strength between thalamic networks and DMN was associated with greater intake of protein in the first week (β = 0.17; 95% CI 0.11, 0.23, p < 0.001) but lower intakes of fat (β = − 0.06; 95% CI − 0.09, − 0.02, p = 0.001) and carbohydrates (β = − 0.03; 95% CI − 0.04, − 0.01, p = 0.003). Connectivity strength was also associated with protein intake during the first month (β = 0.22; 95% CI 0.06, 0.37, p = 0.006). Importantly, greater thalamic-DMN connectivity strength was associated with higher processing speed indices (β = 26.9; 95% CI 4.21, 49.49, p = 0.02) and visual processing scores (β = 9.03; 95% CI 2.27, 15.79, p = 0.009). Optimizing early protein intake may contribute to promoting long-term brain health in preterm-born children.

Discovering Body Positivity & Self-Image (Gender Equality Coalition Of Ontario), Ella Clarke, Morolayo Ilori, Melanie Peck, Hannah Polley, Mili Shah

Medical Sciences 4300A: Addressing Healthcare Misconceptions Using Scientific Inquiry

Body image refers to the way we perceive our bodies, and it can positively or negatively impact physical and mental health (Alleva et al., 2015). Unfortunately, negative body image is becoming more common with some studies finding that 65% of young people are dissatisfied with their bodies (Linardon et al., 2021). This can lead to a variety of psychological and behavioral problems and disorders such as body dysmorphia or eating disorders (Alleva et al., 2015). However, many of these consequences associated with negative body image can be circumvented by learning to foster positive body images through building self-esteem (Jessie’s Legacy, …

Engaging Peers To Promote Wellbeing And Inclusion Of Newcomer Students: A Call For Equity-Informed Peer Interventions, Claire Crooks, Natalia Kubishyn, Amira Noyes, Gina Kayssi

Education Publications

Although newcomer youth demonstrate high levels of resiliency, many experience challenges in emotional, linguistic, academic, and social functioning. Over the past decade, some promising school-based psychosocial interventions for newcomer youth have been developed. These interventions are necessary, but not sufficient to promote well-being. Without attention to the larger context, focusing solely on the skills and adjustment of newcomer youth could potentially stigmatize students further. There is a need to engage non-newcomer peers for two reasons. First, peer relationships and inclusion are important predictors of well-being. Second, from an equity lens, there is a need to create environments that promote youth …

Interventions For Preventing Relapse Or Recurrence Of Major Depressive Disorder In Adults In A Primary Care Setting: A Network Meta-Analysis, Andrew S. Moriarty, Lindsay Robertson, Faraz Mughal, Natalie Cook, Simon Gilbody, Dean Mcmillan, Carolyn A. Chew-Graham, Shehzad Ali, Sarah E. Hetrick, Rachel Churchill, Nicholas Meader

Epidemiology and Biostatistics Publications

Objectives: This is a protocol for a Cochrane Review (intervention). The objectives are as follows:. The aim is to assess, using network meta-analysis (NMA), the effectiveness and safety of interventions for preventing relapse-recurrence of depression in adults in a primary care setting. NMA is a technique for comparing three or more interventions simultaneously in a single analysis by combining both direct and indirect evidence across a network of studies. The objectives are to:. estimate the relative effectiveness of pharmacological, psychological and other interventions to prevent relapse-recurrence, compared with each other and controls (e.g. pill placebo, treatment as usual) on relapse-recurrence …

Musical Instrument Familiarity Affects Statistical Learning Of Tone Sequences., Stephen C Van Hedger, Ingrid Johnsrude, Laura J Batterink

Brain and Mind Institute Researchers' Publications

Most listeners have an implicit understanding of the rules that govern how music unfolds over time. This knowledge is acquired in part through statistical learning, a robust learning mechanism that allows individuals to extract regularities from the environment. However, it is presently unclear how this prior musical knowledge might facilitate or interfere with the learning of novel tone sequences that do not conform to familiar musical rules. In the present experiment, participants listened to novel, statistically structured tone sequences composed of pitch intervals not typically found in Western music. Between participants, the tone sequences either had the timbre of artificial, …

Resting-State Functional Connectivity And Reading Subskills In Children, Alexandra M. Cross, Reshma Ramdajal, Lien Peters, Matthew R.J. Vandermeer, Elizabeth P. Hayden, Jan C. Frijters, Karen A. Steinbach, Maureen W. Lovett, Lisa M.D. Archibald, Marc F. Joanisse

Paediatrics Publications

Individual differences in reading ability have been linked to characteristics of functional connectivity in the brain in both children and adults. However, many previous studies have used single or composite measures of reading, leading to difficulty characterizing the role of functional connectivity in discrete subskills of reading. The present study addresses this issue using resting-state fMRI to examine how resting-state functional connectivity (RSFC) related to individual differences in children's reading subskills, including decoding, sight word reading, reading comprehension, and rapid automatized naming (RAN). Findings showed both positive and negative RSFC-behaviour relationships that diverged across different reading subskills. Positive relationships included …

Erratum: The Good Food For Learning Universal Curriculum-Integrated Healthy School Lunch Intervention: Protocol For A Two-Year Matched Control Pre-Post And Case Study (Jmir Research Protocols (2021) 10:9 (E30899) Doi: 10.2196/30899), Rachel Engler-Stringer, Jennifer Black, Nazeem Muhajarine, Wanda Martin, Jason Gilliland, Janet Mcvittie, Sara Kirk, Hannah Wittman, Amin Mousavi, Sinikka Elliott, Sylvana Tu, Brent Hills, Gordon Androsoff, Debbie Field, Brit Macdonald, Chelsea Belt, Hassan Vatanparast

Paediatrics Publications

In "The Good Food for Learning Universal Curriculum-Integrated Healthy School Lunch Intervention: Protocol for a Two-Year Matched Control Pre-Post and Case Study" (JMIR Res Protoc 2021;10(9):e30899), one error was noted. In the originally published paper, one author, Sylvana Tu, was not included in the list of authors. Sylvana Tu has now been included in the authorship list between authors Sinikka Elliott and Brent Hills. Sylvana Tu's author affiliation has also been added as follows: Saskatchewan Population Health Evaluation and Research Unit, University of Saskatchewan, Saskatoon, SK, Canada This affiliation has been added as affiliation 9 in the corrected paper, and …

Family Functioning As A Moderator In The Relation Between Perceived Stress And Psychotic-Like Experiences Among Adolescents During Covid-19, Zhipeng Wu, Zhulin Zou, Feiwen Wang, Zhibiao Xiang, Mengran Zhu, Yicheng Long, Haojuan Tao, Lena Palaniyappan, Zhening Liu

Brain and Mind Institute Researchers' Publications

Background: The COVID-19 pandemic has increased psychological stress among adolescents, and the relation between perceived stress (PS) and psychotic-like experiences (PLEs) has been well-established. However, little is known about the role of family functioning (FF) in this relation, especially when adolescents experienced the extended lockdown period with family members. Methods: A total of 4807 adolescents completed this retrospective paper-and-pencil survey after school reopening between May 14th and June 6th, 2020 in Hunan Province, China. We measured PS with the Perceived stress scale (PSS-10), PLEs with the eight positive items from Community Assessment of Psychic Experiences (CAPE-8), and FF with the …

Loneliness Unlocked: Associations With Smartphone Use And Personality, Kristi Baerg Macdonald, Julie Aitken Schermer

Management and Organizational Studies Publications

Communication and relationships have been dramatically altered among emerging adults thanks to the rapid adoption of the smartphone in just over a decade. Studying the effects of evolving personal technology helps researchers understand both the detriments of widespread adoption and the benefits that accompany the technology. One such area of concern is the relationship of technology with loneliness. Emerging adulthood is described as the period of transition from adolescence to adulthood, taking place from age 18–25. This period is characterized by change, exploration, but also a vulnerability to psychological distress. Young adults are not only at greater risk of loneliness …

Eveloping A Suitability Assessment Criteria For Software Developers: Behavioral Assessment Using Psychometric Test, Jayati Gulati, Bharti Suri, Luiz Fernando Capretz, Bimlesh Wadhwa, Anu Singh Lather

Electrical and Computer Engineering Publications

A suitability assessment instrument for software developers was created using a psychometric criteria that identify the impact of behavior on the performance of software engineers. The instrument uses a questionnaire to help both individuals and IT recruiters to identify the psychological factors that affect the working performance of software engineers. Our study identifies the relationship between the behavioral drivers and the programming abilities of the subjects. In order to evaluate the instrument, a total of 100 respondents were compared on the basis of their programming skills and nine behavioral drivers. It was concluded that there is a direct relationship between …

Racial Limitations On The Gender, Risk, Religion & Politics Model, Amanda Friesen

Political Science Publications

Risk aversion dampens political participation and heightens religiosity, with concentrated effects among women. Yet, little is known about how intersecting identities moderate these psychological correlates of religiosity and political engagement. In this paper, we theorize that the risk-religion-politics relationship is gendered and racialized. Using a nationally representative survey, we show that political participation is more strongly correlated with risk for Black women than for any other race-gender group. For religiosity, however, we find little evidence that risk is related to religiosity among Black women, while highly correlated with white women's religious engagement. For men—whether Black or white—risk exhibits a modest, …

Sulcation Of The Intraparietal Sulcus Is Related To Symbolic But Not Non-Symbolic Number Skills, M. Roell, A. Cachia, A. A. Matejko, O. Houdé, D. Ansari, G. Borst

Paediatrics Publications

Understanding the constraints, including biological ones, that may influence mathematical development is of great importance because math ability is a key predictor of career success, income and even psychological well-being. While research in developmental cognitive neuroscience of mathematics has extensively studied the key functional regions for processing numbers, particularly the horizontal segment of intraparietal sulcus (HIPS), few studies have investigated the effects of early cerebral constraints on later mathematical abilities. In this pre-registered study, we investigated whether variability of the sulcal pattern of the HIPS, a qualitative feature of the brain determined in-utero and not affected by brain maturation and …

The Mental Well-Being And Coping Strategies Of Canadian Adolescents During The Covid-19 Pandemic: A Qualitative, Cross-Sectional Study, Kendra Nelson Ferguson, Stephanie E. Coen, Danielle Tobin, Gina Martin, Jamie A. Seabrook, Jason A. Gilliland

Paediatrics Publications

BACKGROUND: Qualitative research is lacking on the mental well-being of adolescents during the COVID-19 pandemic. The aim of this study was to explore the feelings and emotions adolescents experienced during the first wave of the COVID-19 pandemic and the coping strategies they identified and employed to manage those emotions. METHODS: Participants living in Canada aged 13-19 years were recruited through social media platforms and youth-serving organizations. Qualitative data were gathered from 2 open-ended questions included in a youth-informed cross-sectional online survey: "What feelings and emotions have you experienced around the pandemic?" and "What coping strategies have you used during the …

Children's Sleep During Covid-19: How Sleep Influences Surviving And Thriving In Families, Nicole E. Mackenzie, Elizabeth Keys, Wendy A. Hall, Reut Gruber, Isabel M. Smith, Evelyn Constantin, Roger Godbout, Robyn Stremler, Graham J. Reid, Ana Hanlon-Dearman, Cary A. Brown, Sarah Shea, Shelly K. Weiss, Osman Ipsiroglu, Manisha Witmans, Christine T. Chambers, Pantelis Andreou, Esmot Begum, Penny Corkum

Paediatrics Publications

Objective The COVID-19 pandemic has the potential to disrupt the lives of families and may have implications for children with existing sleep problems. As such, we aimed to: (1) characterize sleep changes during the COVID-19 pandemic in children who had previously been identified as having sleep problems, (2) identify factors contributing to sleep changes due to COVID-19 safety measures, and (3) understand parents and children s needs to support sleep during the pandemic. Methods Eighty-five Canadian parents with children aged 4 14 years participated in this explanatory sequential, mixed-methods study using an online survey of children s and parents sleep, …

Regional Brain And Spinal Cord Volume Loss In Spinocerebellar Ataxia Type 3, Jennifer Faber, Tamara Schaprian, Koyak Berkan, Kathrin Reetz, Marcondes Cavalcante França, Thiago Junqueira Ribeiro De Rezende, Jiang Hong, Weihua Liao, Bart Van De Warrenburg, Judith Van Gaalen, Alexandra Durr, Fanny Mochel, Paola Giunti, Hector Garcia-Moreno, Ludger Schoels, Holger Hengel, Matthis Synofzik, Benjamin Bender, Gulin Oz, James Joers, Jereon J. De Vries, Jun Suk Kang, Dagmar Timmann-Braun, Heike Jacobi, Jon Infante, Richard Joules, Sandro Romanzetti, Jorn Diedrichsen, Matthias Schmid, Robin Wolz, Thomas Klockgether

Brain and Mind Institute Researchers' Publications

Background: Given that new therapeutic options for spinocerebellar ataxias are on the horizon, there is a need for markers that reflect disease-related alterations, in particular, in the preataxic stage, in which clinical scales are lacking sensitivity. Objective: The objective of this study was to quantify regional brain volumes and upper cervical spinal cord areas in spinocerebellar ataxia type 3 in vivo across the entire time course of the disease. Methods: We applied a brain segmentation approach that included a lobular subsegmentation of the cerebellum to magnetic resonance images of 210 ataxic and 48 preataxic spinocerebellar ataxia type 3 mutation carriers …

Pitch Discrimination Is Better For Synthetic Timbre Than Natural Musical Instrument Timbres, Despite Familiarity, Emma Holmes, Elizabeth Kinghorn, Lucy Mcgarry, Elizabeth Busari, Timothy D. Griffiths, Ingrid Johnsrude

Brain and Mind Institute Researchers' Publications

Pitch discrimination is better for complex tones than for pure tones, but how more subtle differences in timbre affect pitch discrimination is not fully understood. This study compared pitch discrimination thresholds of flat-spectrum harmonic complex tones with those of natural sounds played by musical instruments of three different timbres (violin, trumpet, and flute). To investigate whether natural familiarity with sounds of particular timbres affects pitch discrimination thresholds, this study recruited musicians who were trained on one of the three instruments. We found that flautists and trumpeters could discriminate smaller differences in pitch for artificial flat-spectrum tones, despite their unfamiliar timbre, …

Functional Organization Of Frontoparietal Cortex In The Marmoset Investigated With Awake Resting-State Fmri, Yuki Hori, Justine C. Cléry, David J. Schaeffer, Ravi S. Menon, Stefan Everling

Brain and Mind Institute Researchers' Publications

Frontoparietal networks contribute to complex cognitive functions in humans and macaques, such as working memory, attention, task-switching, response suppression, grasping, reaching, and eye movement control. However, there has been no comprehensive examination of the functional organization of frontoparietal networks using functional magnetic resonance imaging in the New World common marmoset monkey (Callithrix jacchus), which is now widely recognized as a powerful nonhuman primate experimental animal. In this study, we employed hierarchical clustering of interareal blood oxygen level-dependent signals to investigate the hypothesis that the organization of the frontoparietal cortex in the marmoset follows the organizational principles of the macaque frontoparietal …

Sustained Neural Activity Correlates With Rapid Perceptual Learning Of Auditory Patterns, Björn Herrmann, Kurdo Araz, Ingrid S. Johnsrude

Brain and Mind Institute Researchers' Publications

Repeating structures forming regular patterns are common in sounds. Learning such patterns may enable accurate perceptual organization. In five experiments, we investigated the behavioral and neural signatures of rapid perceptual learning of regular sound patterns. We show that recurring (compared to novel) patterns are detected more quickly and increase sensitivity to pattern deviations and to the temporal order of pattern onset relative to a visual stimulus. Sustained neural activity reflected perceptual learning in two ways. Firstly, sustained activity increased earlier for recurring than novel patterns when participants attended to sounds, but not when they ignored them; this earlier increase mirrored …

How Long Do Mood Induction Procedure (Mip) Primes Really Last? Implications For Cognitive Vulnerability Research., Jennifer C P Gillies, David J A Dozois

Psychology Publications

BACKGROUND: Mood Induction Procedures (MIPs) are used widely in research on cognitive vulnerability to depression. Although empirical evidence supports certain MIPs as effective, little research has evaluated whether MIP-induced sad moods are sufficiently persistent. This study aimed to determine (1) how long an MIP-induced mood lasts according to commonly used operational definitions and (2) whether these findings vary according to the type of MIP used.

METHODS: Four-hundred-and-one undergraduate students were randomly assigned to one of three commonly used sad MIPs (music, memory, music+memory) or to one of three matched neutral MIPs. Mood was repeatedly measured immediately prior to and following …

Becoming An Ambidextrous Learning Organization: Leadership For Confidence In A Resource-Dependent Nonprofit Environment, Lena J. Patterson

The Dissertation in Practice at Western University

A leader in a nonprofit organization needs the confidence of their team to deliver stable, high-value services to stakeholders while simultaneously adapting to environmental changes. This balance is critical for the Collaborative, the nonprofit organization at the centre of this organizational improvement plan (OIP). The Collaborative’s operating conditions are characterized by reliance on short-term government funding, environmental uncertainty, complex stakeholder relationships, and a dual focus on social mission and financial viability. The problem of practice is a loss of confidence in leadership, which is triggered by these complex conditions. At the heart of this OIP is the argument that the …

Structural Distress: Experiences Of Moral Distress Related To Structural Stigma During The Covid-19 Pandemic, Javeed Sukhera, Chetana Kulkarni, Taryn Taylor

Paediatrics Publications

Introduction: The COVID-19 pandemic has taken a significant toll on the health of structurally vulnerable patient populations as well as healthcare workers. The concepts of structural stigma and moral distress are important and interrelated, yet rarely explored or researched in medical education. Structural stigma refers to how discrimination towards certain groups is enacted through policy and practice. Moral distress describes the tension and conflict that health workers experience when they are unable to fulfil their duties due to circumstances outside of their control. In this study, the authors explored how resident physicians perceive moral distress in relation to structural stigma. …

The Differential Calibration Of The Hpa Axis As A Function Of Trauma Versus Adversity: A Systematic Review And P-Curve Meta-Analyses, Niki Hosseini-Kamkar, Cassandra Lowe, J. Bruce Morton

Paediatrics Publications

Although there is an abundance of evidence linking the function of the hypothalamic-pituitary-adrenal (HPA) axis to adverse early-life experiences, the precise nature of the association remains unclear. Some evidence suggests early-life adversity leads to cortisol hyper-reactivity, while other evidence suggests adversity leads to cortisol hypo-reactivity. Here, we distinguish between trauma and adversity, and use p-curves to interrogate the conflicting literature. In Study 1, trauma was operationalized according to DSM-5 criteria; the p-curve analysis included 68 articles and revealed that the literature reporting associations between trauma and blunted cortisol reactivity contains evidential value. Study 2 examined the relationship between adversity and …

The Bilingual Advantage In Children’S Executive Functioning Is Not Related To Language Status: A Meta-Analytic Review, Cassandra J. Lowe, Isu Cho, Samantha F. Goldsmith, J. Bruce Morton

Paediatrics Publications

There is considerable debate about whether bilingual children have an advantage in executive functioning relative to monolingual children. In the current meta-analysis, we addressed this debate by comprehensively reviewing the available evidence. We synthesized data from published studies and unpublished data sets, which equated to 1,194 effect sizes from 10,937 bilingual and 12,477 monolingual participants between the ages of 3 and 17 years. Bilingual language status had a small overall effect on children’s executive functioning (g =.08, 95% confidence interval = [.01,.14]). However, the effect of language status on children’s executive functioning was indistinguishable from zero (g = −.04) after …

A Novel Three-Choice Touchscreen Task To Examine Spatial Attention And Orienting Responses In Rodents, Faraj L. Haddad, Maryam Ghahremani, Cleusa De Oliveira, Ella E. Doornaert, Kevin D. Johnston, Stefan Everling, Susanne Schmid

Brain and Mind Institute Researchers' Publications

Mammalian orienting behavior consists of coordinated movements of the eyes, head, pinnae, vibrissae, or body to attend to an external stimulus. The present study aimed to develop a novel operant task using a touch-screen system to measure spatial attention. In this task, rats were trained to nose-poke a light stimulus presented in one of three locations. The stimulus was presented more frequently in the center location to develop spatial attention bias toward the center stimulus. Changes in orienting responses were detected by measuring the animals’ response accuracy and latency to stimuli at the lateral locations, following reversible unilateral chemogenetic inactivation …

Adopting A Conceptual Validity Framework For Testing In Speech-Language Pathology, Olivia Daub, Barbara Jane Cunningham, Marlene P. Bagatto, Andrew M. Johnson, Elaine Y. Kwok, Rachael E. Smyth, Janis Oram Cardy

Communication Sciences and Disorders Publications

Purpose Limited evidence-based guidelines for test selection continue to result in inconsistency in test use and interpretation in speech-language pathology. A major barrier is the lack of explicit and consistent adoption of a validity framework by our field. In this viewpoint, we argue that adopting the conceptual validity framework in the Standards for Educational and Psychological Testing (American Educational Research Association et al., 2014) would support both the development of more meaningful and feasible clinical tests and more appropriate use and interpretation of tests in speech-language pathology. Method We describe and evaluate the (American Educational Research Association et al., 2014) …

More Than Nail Deep: The Effect Of Efinaconazole 10% Treatment On The Quality Of Life In Patients With Onychomycosis: A Post Hoc Study, Aditya K. Gupta, Maanasa Venkataraman, Emma M. Quinlan, Madhulika A. Gupta, Naveen Anbalagan, Rachel Lyons

Paediatrics Publications

Introduction: Onychomycosis is a common, difficult-to-treat fungal nail infection. Clinical signs include nail discoloration and thickening, which patients often find embarrassing, causing a negative impact on their quality of life (QOL). Methods: In this post hoc study, we analyze the effect of efinaconazole 10% solution on a patient's QOL using patient-reported scores from the OnyCOE-t™ questionnaire (appearance, stigma, physical problems, symptom frequency, symptom bothersomeness, treatment satisfaction, and overall problem). Higher scores corresponded to better functioning, thus higher QOL. Results: Efinaconazole 10% treatment and clinical efficacy were positively correlated with improved QOL in all domains for all groups, except with symptom …