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Using Meta-Ethnography To Synthesize Research: A Worked Example Of The Relations Between Personality On Software Team Processes, Fabio Q. B. Silva Dr., Shirley S. J. O. Cruz, Tatiana B. Gouveia, Luiz Fernando Capretz Sep 2013

Using Meta-Ethnography To Synthesize Research: A Worked Example Of The Relations Between Personality On Software Team Processes, Fabio Q. B. Silva Dr., Shirley S. J. O. Cruz, Tatiana B. Gouveia, Luiz Fernando Capretz

Electrical and Computer Engineering Publications

Context: The increase in the number of qualitative and mixed-methods research published in software engineering has created an opportunity for further knowledge generation through the synthesis of studies with similar aims. This is particularly true in the research on human aspects because the phenomena of interest are often better understood using qualitative research. However, the use of qualitative synthesis methods is not widespread and worked examples of their consistent application in software engineering are needed. Objective: To explore the use of meta-ethnography in the synthesis of empirical studies in software engineering through an example using studies about the relations between …

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Developing Physical Activity Interventions For Adults With Spinal Cord Injury. Part 2: Motivational Counseling And Peer-Mediated Interventions For People Intending To Be Active, Amy E. Latimer-Cheung, Kelly P. Arbour-Nicitopoulos, Lawrence R. Brawley, Casey Gray, A. Justine Wilson, Harry Prapavessis, Jennifer R. Tomasone, Dalton L. Wolfe, Kathleen A.Martin Ginis Aug 2013

Developing Physical Activity Interventions For Adults With Spinal Cord Injury. Part 2: Motivational Counseling And Peer-Mediated Interventions For People Intending To Be Active, Amy E. Latimer-Cheung, Kelly P. Arbour-Nicitopoulos, Lawrence R. Brawley, Casey Gray, A. Justine Wilson, Harry Prapavessis, Jennifer R. Tomasone, Dalton L. Wolfe, Kathleen A.Martin Ginis

Paediatrics Publications

Objective: The majority of people with spinal cord injury (SCI) do not engage in sufficient leisure-time physical activity (LTPA) to attain fitness benefits; however, many have good intentions to be active. This paper describes two pilot interventions targeting people with SCI who are insufficiently active but intend to be active (i.e., "intenders"). Method: Study 1 examined the effects of a single, telephone-based counseling session on self-regulatory efficacy, intentions, and action plans for LTPA among seven men and women with paraplegia or tetraplegia. Study 2 examined the effects of a home-based strengthtraining session, delivered by a peer and a fitness trainer, …

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A Multivariate Method To Determine The Dimensionality Of Neural Representation From Population Activity., Jörn Diedrichsen, Tobias Wiestler, Naveed Ejaz Aug 2013

A Multivariate Method To Determine The Dimensionality Of Neural Representation From Population Activity., Jörn Diedrichsen, Tobias Wiestler, Naveed Ejaz

Brain and Mind Institute Researchers' Publications

How do populations of neurons represent a variable of interest? The notion of feature spaces is a useful concept to approach this question: According to this model, the activation patterns across a neuronal population are composed of different pattern components. The strength of each of these components varies with one latent feature, which together are the dimensions along which the population represents the variable. Here we propose a new method to determine the number of feature dimensions that best describes the activation patterns. The method is based on Gaussian linear classifiers that use only the first d most important pattern …

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Skill Learning Strengthens Cortical Representations Of Motor Sequences., Tobias Wiestler, Jörn Diedrichsen Jul 2013

Skill Learning Strengthens Cortical Representations Of Motor Sequences., Tobias Wiestler, Jörn Diedrichsen

Brain and Mind Institute Researchers' Publications

Motor-skill learning can be accompanied by both increases and decreases in brain activity. Increases may indicate neural recruitment, while decreases may imply that a region became unimportant or developed a more efficient representation of the skill. These overlapping mechanisms make interpreting learning-related changes of spatially averaged activity difficult. Here we show that motor-skill acquisition is associated with the emergence of highly distinguishable activity patterns for trained movement sequences, in the absence of average activity increases. During functional magnetic resonance imaging, participants produced either four trained or four untrained finger sequences. Using multivariate pattern analysis, both untrained and trained sequences could …

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Motor Control And Nonword Repetition In Specific Working Memory Impairment And Sli, Lisa M.D. Archibald, Marc F. Joanisse, Benjamin Munson Jul 2013

Motor Control And Nonword Repetition In Specific Working Memory Impairment And Sli, Lisa M.D. Archibald, Marc F. Joanisse, Benjamin Munson

Paediatrics Publications

PURPOSE:: Debate around the underlying cognitive factors leading to poor performance in the repetition of nonwords by children with developmental impairments in language has centered around phonological short-term memory, lexical knowledge, and other factors. This study examines the impact of motor control demands on nonword repetition in groups of school children with specific impairments in language, working memory, or both. METHOD:: Children repeated two lists of nonwords matched for motoric complexity either without constraint or with a gummi bear bite block held between their teeth. The bite block required motoric compensation to reorganize the motor plan for speech production. RESULTS:: …

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Behavioral Sleep Problems And Their Potential Impact On Developing Executive Function In Children, Kathryn Turnbull, Graham J. Reid, J. Bruce Morton Jul 2013

Behavioral Sleep Problems And Their Potential Impact On Developing Executive Function In Children, Kathryn Turnbull, Graham J. Reid, J. Bruce Morton

Paediatrics Publications

Bedtime resistance and night waking are common sleep problems throughout childhood, especially in the early years. These sleep problems may lead to difficulties in neurobehavioral functioning, but most research into childhood sleep problems has not emphasized the importance of the developmental context in which disruptions in neurobehavioral and daytime functioning occur. We review the development of sleep as well as executive functioning (EF) in childhood and suggest that EF may be particularly vulnerable to the effects of these common childhood sleep problems because of its prolonged course of maturation. Behavioral problems associated with common sleep problems suggest poor self-regulation in …

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Erps Reveal The Temporal Dynamics Of Auditory Word Recognition In Specific Language Impairment., Jeffrey G Malins, Amy S Desroches, Erin K Robertson, Randy Lynn Newman, Lisa M D Archibald, Marc F Joanisse Jul 2013

Erps Reveal The Temporal Dynamics Of Auditory Word Recognition In Specific Language Impairment., Jeffrey G Malins, Amy S Desroches, Erin K Robertson, Randy Lynn Newman, Lisa M D Archibald, Marc F Joanisse

Brain and Mind Institute Researchers' Publications

We used event-related potentials (ERPs) to compare auditory word recognition in children with specific language impairment (SLI group; N=14) to a group of typically developing children (TD group; N=14). Subjects were presented with pictures of items and heard auditory words that either matched or mismatched the pictures. Mismatches overlapped expected words in word-onset (cohort mismatches; see: DOLL, hear: dog), rhyme (CONE -bone), or were unrelated (SHELL -mug). In match trials, the SLI group showed a different pattern of N100 responses to auditory stimuli compared to the TD group, indicative of early auditory processing differences in SLI. However, the phonological mapping …

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Dynamic And Opposing Adjustment Of Movement Cancellation And Generation In An Oculomotor Countermanding Task., Brian D Corneil, Joshua C Cheng, Samanthi C Goonetilleke Jun 2013

Dynamic And Opposing Adjustment Of Movement Cancellation And Generation In An Oculomotor Countermanding Task., Brian D Corneil, Joshua C Cheng, Samanthi C Goonetilleke

Brain and Mind Institute Researchers' Publications

Adaptive adjustments of strategies help optimize behavior in a dynamic and uncertain world. Previous studies in the countermanding (or stop-signal) paradigm have detailed how reaction times (RTs) change with trial sequence, demonstrating adaptive control of movement generation. Comparatively little is known about the adaptive control of movement cancellation in the countermanding task, mainly because movement cancellation implies the absence of an outcome and estimates of movement cancellation require hundreds of trials. Here, we exploit a within-trial proxy of movement cancellation based on recordings of neck muscle activity while human subjects attempted to cancel large eye-head gaze shifts. On a subset …

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Two Distinct Ipsilateral Cortical Representations For Individuated Finger Movements., Jörn Diedrichsen, Tobias Wiestler, John W Krakauer Jun 2013

Two Distinct Ipsilateral Cortical Representations For Individuated Finger Movements., Jörn Diedrichsen, Tobias Wiestler, John W Krakauer

Brain and Mind Institute Researchers' Publications

Movements of the upper limb are controlled mostly through the contralateral hemisphere. Although overall activity changes in the ipsilateral motor cortex have been reported, their functional significance remains unclear. Using human functional imaging, we analyzed neural finger representations by studying differences in fine-grained activation patterns for single isometric finger presses. We demonstrate that cortical motor areas encode ipsilateral movements in 2 fundamentally different ways. During unimanual ipsilateral finger presses, primary sensory and motor cortices show, underneath global suppression, finger-specific activity patterns that are nearly identical to those elicited by contralateral mirror-symmetric action. This component vanishes when both motor cortices are …

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Suicidal Ideation In Callers To A Crisis Hotline In Mumbai,, Amresh Srivastava, Megan Johnston, Larry Stitt, Meghana Thanksr, Sunita Iyer, Nilesh Shah, David Lester Jun 2013

Suicidal Ideation In Callers To A Crisis Hotline In Mumbai,, Amresh Srivastava, Megan Johnston, Larry Stitt, Meghana Thanksr, Sunita Iyer, Nilesh Shah, David Lester

Data and Test Instruments

Suicidal ideation in callers to a crisis hotline in Mumbai, India Amresh K. Shrivastava1,2, Megan Johnston3, Larry Stitt4, Meghana Thakar5, Sunita Iyer6, Nilesh Shah7 and David Lester8* 1Silver Mind Hospital and Mental Health Foundation of India, (PRERANA Charitable Trust) Mumbai. 2Department of Psychiatry, University of Western Ontario, London, Canada. 3Department of Psychology, University of Toronto, 100 St. George St., Toronto, Ontario, Canada, M5S 2M2. 4Biostatistical Support Unit, Department of Epidemiology and Biostatistics, The University of Western Ontario, London, Ontario, Canada. 5Silver mind Hospital, Mumbai, Currently, Child and Adolescent Mental Health Practitioner, Lambeth CAMHS Early Intervention Team, South London and Maudsley …

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Prefrontal Neurons Of Opposite Spatial Preference Display Distinct Target Selection Dynamics., Therese Lennert, Julio C Martinez-Trujillo May 2013

Prefrontal Neurons Of Opposite Spatial Preference Display Distinct Target Selection Dynamics., Therese Lennert, Julio C Martinez-Trujillo

Brain and Mind Institute Researchers' Publications

Neurons in the primate dorsolateral prefrontal cortex (dlPFC) of one hemisphere are selective for the location of attended targets in both visual hemifields. Whether dlPFC neurons with selectivity for opposite hemifields directly compete with each other for target selection or instead play distinct roles during the allocation of attention remains unclear. We explored this issue by recording neuronal responses in the right dlPFC of two macaques while they allocated attention to a target in one hemifield and ignored a distracter on the opposite side. Forty-nine percent of the recorded neurons were target location selective. Neurons selective for contralateral targets (58%) …

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Decoding The Neural Mechanisms Of Human Tool Use., Jason P Gallivan, D Adam Mclean, Kenneth F Valyear, Jody C Culham May 2013

Decoding The Neural Mechanisms Of Human Tool Use., Jason P Gallivan, D Adam Mclean, Kenneth F Valyear, Jody C Culham

Brain and Mind Institute Researchers' Publications

Sophisticated tool use is a defining characteristic of the primate species but how is it supported by the brain, particularly the human brain? Here we show, using functional MRI and pattern classification methods, that tool use is subserved by multiple distributed action-centred neural representations that are both shared with and distinct from those of the hand. In areas of frontoparietal cortex we found a common representation for planned hand- and tool-related actions. In contrast, in parietal and occipitotemporal regions implicated in hand actions and body perception we found that coding remained selectively linked to upcoming actions of the hand whereas …

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Measurement Of Clinical Risk Of Stigma And Discrimination Of Mental Illnesses, Amresh Srivastava, Yves Bureau, Nitika Rewari, Megan Johnston, Arman Panday, Nilesh Shah May 2013

Measurement Of Clinical Risk Of Stigma And Discrimination Of Mental Illnesses, Amresh Srivastava, Yves Bureau, Nitika Rewari, Megan Johnston, Arman Panday, Nilesh Shah

Data and Test Instruments

Abstract Background: Stigma and discrimination continue to be a reality in the lives of people suffering from mental illness, particularly schizophrenia, and prove to be some of the greatest barriers to access care, continue to remain under care, and regain a normal lifestyle and health. Research advances have defined stigma, assessed its implications and have even examined intervention strategies for dealing with stigma. The delay in treatment due to stigma causes potential complications like suicide, violence, harm to others and deterioration in capacity to look after one’s physical health. These are preventable clinical complications. In order to deal with the …

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The Human Brain Processes Syntax In The Absence Of Conscious Awareness., Laura Batterink, Helen J Neville May 2013

The Human Brain Processes Syntax In The Absence Of Conscious Awareness., Laura Batterink, Helen J Neville

Brain and Mind Institute Researchers' Publications

Syntax is the core computational component of language. A longstanding idea about syntactic processing is that it is generally not available to conscious access, operating autonomously and automatically. However, there is little direct neurocognitive evidence on this issue. By measuring event-related potentials while human observers performed a novel cross-modal distraction task, we demonstrated that syntactic violations that were not consciously detected nonetheless produced a characteristic early neural response pattern, and also significantly delayed reaction times to a concurrent task. This early neural response was distinct from later neural activity that was observed only to syntactic violations that were consciously detected. …

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Soft Skills And Software Development: A Reflection From The Software Industry, Faheem Ahmed, Luiz Fernando Capretz, Salah Bouktif, Piers Campbell May 2013

Soft Skills And Software Development: A Reflection From The Software Industry, Faheem Ahmed, Luiz Fernando Capretz, Salah Bouktif, Piers Campbell

Electrical and Computer Engineering Publications

Psychological theories assert that not everybody is fit for every task, as people have different personality traits and abilities. Often, personality traits are expressed in people’s soft skills. That is, the way people perceive, plan and execute any assigned task is influenced by their set of soft skills. Most of the studies carried out on the human factor in IS concentrate primarily on personality types. Soft skills have been given comparatively little attention by researchers. We review the literature relating to soft skills and the software engineering and information systems domain before describing a study based on 650 job advertisements …

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Dsm V: Hope Or Hype?, Amresh Srivastava Apr 2013

Dsm V: Hope Or Hype?, Amresh Srivastava

Data and Test Instruments

DSM V: HOPE OR HYPE? Amresh Shrivastava, MD,MPM,MRCPsych,FRCPC Associate professor of Psychiatry Western University London, Ontario Since more than 50 years psychiatric diagnostic is being developed by a number of organisations. As research has advanced in understanding mental illnesses,need for a common language has been felt in order to provide best possible care to our patients. The process of psychiatric diagnosis has evolved significantly. WHO as well APA both have made significant advances in developing diagnostic systems. DSM 5 recently approved by board of trustees by Americal psychiatric Association is scheduled to be released on 18th of May. This document …

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Shared Neural Substrates Of Emotionally Enhanced Perceptual And Mnemonic Vividness, Rebecca M. Todd, Taylor W. Schmitz, Josh Susskind, Adam K. Anderson Apr 2013

Shared Neural Substrates Of Emotionally Enhanced Perceptual And Mnemonic Vividness, Rebecca M. Todd, Taylor W. Schmitz, Josh Susskind, Adam K. Anderson

Brain and Mind Institute Researchers' Publications

It is well known that emotionally salient events are remembered more vividly than mundane ones. Our recent research has demonstrated that such memory vividness is due in part to the subjective experience of emotional events as more perceptually vivid, an effect we call emotion-enhanced vividness, or EEV. The present study built on previously reported research in which fMRI data were collected while participants rated relative levels of visual noise overlaid on emotionally salient and neutral images. Ratings of greater EEV were associated with greater activation in the amygdala, visual cortex, and posterior insula. In the present study, we measured BOLD …

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Children First: It’S Time To Change! Mental Health Promotion, Prevention, And Treatment Informed By Public Health, And Resiliency Approaches, Vicki Schwean, Susan Rodger Mar 2013

Children First: It’S Time To Change! Mental Health Promotion, Prevention, And Treatment Informed By Public Health, And Resiliency Approaches, Vicki Schwean, Susan Rodger

Journal Articles

Although the importance of healthy mental development in children and youth is not disputed, the mental health needs of far too many Canadian children are being ignored. Within the context of recent federal and provincial calls for systemic reform of the mental health care systems for children and youth, we underscore the necessity for ongoing innovation, development, education, and evaluation. This article describes our aims to establish demonstration and research sites focused on promising frameworks that draw from systems of care, public health, and resiliency approaches.

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Dimensional Change Card Sort Performance Associated With Age-Related Differences In Functional Connectivity Of Lateral Prefrontal Cortex, Fredrick Ezekiel, Rachael Bosma, J. Bruce Morton Jan 2013

Dimensional Change Card Sort Performance Associated With Age-Related Differences In Functional Connectivity Of Lateral Prefrontal Cortex, Fredrick Ezekiel, Rachael Bosma, J. Bruce Morton

Paediatrics Publications

The Dimensional Change Card Sort (DCCS) is a standard procedure for assessing executive functioning early in development. In the task, participants switch from sorting cards one way (e.g., by color) to sorting them a different way (e.g., by shape). Traditional accounts associate age-related changes in DCCS performance with circumscribed changes in lateral prefrontal cortex (lPFC) functioning, but evidence of age-related differences in the modulation of lPFC activity by switching is mixed. The current study therefore tested for possible age-related differences in functional connectivity of lPFC with regions that comprise a larger cognitive control network. Functional magnetic resonance imaging (fMRI) data …

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Hd-Cnv: Hotspot Detector For Copy Number Variants., Jenna L Butler, Marjorie Elizabeth Osborne Locke, Kathleen A Hill, Mark Daley Jan 2013

Hd-Cnv: Hotspot Detector For Copy Number Variants., Jenna L Butler, Marjorie Elizabeth Osborne Locke, Kathleen A Hill, Mark Daley

Brain and Mind Institute Researchers' Publications

SUMMARY: Copy number variants (CNVs) are a major source of genetic variation. Comparing CNVs between samples is important in elucidating their potential effects in a wide variety of biological contexts. HD-CNV (hotspot detector for copy number variants) is a tool for downstream analysis of previously identified CNV regions from multiple samples, and it detects recurrent regions by finding cliques in an interval graph generated from the input. It creates a unique graphical representation of the data, as well as summary spreadsheets and UCSC (University of California, Santa Cruz) Genome Browser track files. The interval graph, when viewed with other software …

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Computational Grounded Cognition: A New Alliance Between Grounded Cognition And Computational Modeling, Giovanni Pezzulo, Lawrence W. Barsalou, Angelo Cangelosi, Martin H. Fischer, Ken Mcrae, Michael J. Spivey Jan 2013

Computational Grounded Cognition: A New Alliance Between Grounded Cognition And Computational Modeling, Giovanni Pezzulo, Lawrence W. Barsalou, Angelo Cangelosi, Martin H. Fischer, Ken Mcrae, Michael J. Spivey

Psychology Publications

Grounded theories assume that there is no central module for cognition. According to this view, all cognitive phenomena, including those considered the province of amodal cognition such as reasoning, numeric, and language processing, are ultimately grounded in (and emerge from) a variety of bodily, affective, perceptual, and motor processes. The development and expression of cognition is constrained by the embodiment of cognitive agents and various contextual factors (physical and social) in which they are immersed. The grounded framework has received numerous empirical confirmations. Still, there are very few explicit computational models that implement grounding in sensory, motor and affective processes …

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Information Seeking In Context: Results Of Graduate Student Interviews, Marg Sloan, Kim Mcphee Jan 2013

Information Seeking In Context: Results Of Graduate Student Interviews, Marg Sloan, Kim Mcphee

Western Libraries Publications

The authors conducted a qualitative research study examining the information seeking behaviours of Psychology, Sociology, and Women's Studies graduate students at a large research intensive university to determine: how graduate students find information; the roles that faculty members, fellow graduate students and librarians play in the information search; and graduate students' knowledge of information resources and services. The context of graduate student information seeking was uncovered through an analysis of the data using the trichotomy of people, place and information. Across the disciplines, M.A. students were more likely to ask for librarian assistance than Ph.D. students. The interview findings will …

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Semantic Memory, Ken Mcrae, Michael Jones Jan 2013

Semantic Memory, Ken Mcrae, Michael Jones

Psychology Publications

No abstract provided.

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Constraint-Based Models Of Sentence Processing, Ken Mcrae, Kazunaga Matsuki Jan 2013

Constraint-Based Models Of Sentence Processing, Ken Mcrae, Kazunaga Matsuki

Psychology Publications

No abstract provided.

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Evaluation Of The Internal Consistency, Factor Structure, And Validity Of The Depression Change Expectancy Scale, Kari M. Eddington, David J. A. Dozois, Barb J. Backs-Dermott Jan 2013

Evaluation Of The Internal Consistency, Factor Structure, And Validity Of The Depression Change Expectancy Scale, Kari M. Eddington, David J. A. Dozois, Barb J. Backs-Dermott

Psychology Publications

The psychometric properties and predictive validity of the Depression Change Expectancy Scale (DCES), a modification of an expectancy scale originally developed for patients with anxiety disorders, were examined in two studies. In Study 1, the 20-item scale was administered along with a battery of questionnaires to a sample of 416 dysphoric undergraduate students and demonstrated good internal consistency. A two-factor solution most parsimoniously accounted for the variance, with one factor containing all pessimistically worded items (DCES-P) and the second containing all optimistically worded items (DCES-O). The DCES-P showed patterns of correlations with other measures of related constructs consistent with hypothesized …

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Psychological Treatments: Putting Evidence Into Practice And Practice Into Evidence., David J. A. Dozois Jan 2013

Psychological Treatments: Putting Evidence Into Practice And Practice Into Evidence., David J. A. Dozois

Psychology Publications

In June 2011, the Canadian Psychological Association (CPA) Board of Directors launched a task force on the evidence-based practice of psychological treatments. The purpose of this task force was to operationalize what constitutes evidence-based practice in psychological treatment, to make recommendations about how psychologists can best integrate evidence into practice, and to disseminate information to consumers about evidence-based interventions. An important impetus for this task force was the continuing and widening scientist–practitioner gap. There are both barriers and opportunities when it comes to promoting greater reliance on the scientific literature and greater uptake of empirically supported treatments among practitioners. Two …

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Early Maladaptive Schemas, Styles Of Humor And Aggression, David J. A. Dozois, R. A. Martin, B. Faulkner Jan 2013

Early Maladaptive Schemas, Styles Of Humor And Aggression, David J. A. Dozois, R. A. Martin, B. Faulkner

Psychology Publications

The relationship between early maladaptive schemas (EMSs) and psychopathology is thought to be mediated by the use of maladaptive compensatory coping and deficits in adaptive coping. One form of coping that might be affected by EMSs is an individual’s style of humor, which can be adaptive or maladaptive. This study examined the relationships among EMS domains, styles of humor, and aggression. The EMS domain of Impaired Limits was most consistently related to aggression. Moreover, as predicted, an aggressive style of humor mediated the relationship between Impaired Limits and various aspects of aggression (i.e., verbal, physical, and hostility). In addition, self-defeating …

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Intersectionality: Mental Health Interpreters And Clinicians Or Finding The “Sweet Spot” In Therapy, Cathy Chovaz Jan 2013

Intersectionality: Mental Health Interpreters And Clinicians Or Finding The “Sweet Spot” In Therapy, Cathy Chovaz

Psychology Publications

This paper examines the complex and multiple contributions that the mental health clinician, sign language interpreter and Deaf client bring to the mental health context. Building on D-C schema, the author proposes a theoretical framework for understanding the intersection of these factors and the influence on mental health outcomes.

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Acute Alcohol Consumption Impairs Controlled But Not Automatic Processes In A Psychophysical Pointing Paradigm., Kevin Johnston, Brian Timney, Melvyn A Goodale Jan 2013

Acute Alcohol Consumption Impairs Controlled But Not Automatic Processes In A Psychophysical Pointing Paradigm., Kevin Johnston, Brian Timney, Melvyn A Goodale

Brain and Mind Institute Researchers' Publications

Numerous studies have investigated the effects of alcohol consumption on controlled and automatic cognitive processes. Such studies have shown that alcohol impairs performance on tasks requiring conscious, intentional control, while leaving automatic performance relatively intact. Here, we sought to extend these findings to aspects of visuomotor control by investigating the effects of alcohol in a visuomotor pointing paradigm that allowed us to separate the influence of controlled and automatic processes. Six male participants were assigned to an experimental "correction" condition in which they were instructed to point at a visual target as quickly and accurately as possible. On a small …

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Habituation Of Reflexive And Motivated Behavior In Mice With Deficient Bk Channel Function., Marei Typlt, Magdalena Mirkowski, Erin Azzopardi, Peter Ruth, Peter K D Pilz, Susanne Schmid Jan 2013

Habituation Of Reflexive And Motivated Behavior In Mice With Deficient Bk Channel Function., Marei Typlt, Magdalena Mirkowski, Erin Azzopardi, Peter Ruth, Peter K D Pilz, Susanne Schmid

Brain and Mind Institute Researchers' Publications

Habituation is considered the most basic form of learning. It describes the decrease of a behavioral response to a repeated non-threatening sensory stimulus and therefore provides an important sensory filtering mechanism. While some neuronal pathways mediating habituation are well described, underlying cellular/molecular mechanisms are not yet fully understood. In general, there is an agreement that short-term and long-term habituation are based on different mechanisms. Historically, a distinction has also been made between habituation of motivated versus reflexive behavior. In recent studies in invertebrates the large conductance voltage- and calcium-activated potassium (BK) channel has been implicated to be a key player …

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